YING-NAIWANGYING-NAI WANG9310WANG, YING-NAIInstructorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson1515 Holcombe BlvdHouston77030-4009TXAuthorship 1801662Authorship 1848331Authorship 1850262Authorship 1855537Authorship 1859127Authorship 1864971Authorship 1871944Authorship 1875028Authorship 1885669Authorship 1910043Authorship 1943807Authorship 194988417623675Chen YJ, Wang YN, Chang WCThe Journal of biological chemistryERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. J Biol Chem. 2007 Sep 14; 282(37):27215-27228.J Biol Chem2007-07-09T00:00:002007ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression.20498894Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MCLab on a chipHigh speed digital protein interaction analysis using microfluidic single molecule detection system. Lab Chip. 2010 Jul 21; 10(14):1793-8.Lab Chip2010-05-24T00:00:002010High speed digital protein interaction analysis using microfluidic single molecule detection system.20674546Wang YN, Wang H, Yamaguchi H, Lee HJ, Lee HH, Hung MCBiochemical and biophysical research communicationsCOPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):498-504.Biochem Biophys Res Commun2010-07-30T00:00:002010COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport.20877860Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MCThe AnalystRapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. Analyst. 2010 Nov; 135(11):2907-12.Analyst2010-09-28T00:00:002010Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device.20937808Wang YN, Yamaguchi H, Huo L, Du Y, Lee HJ, Lee HH, Wang H, Hsu JM, Hung MCThe Journal of biological chemistryThe translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem. 2010 Dec 03; 285(49):38720-9.J Biol Chem2010-10-11T00:00:002010The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus.23344263Yamaguchi H, Hsu JL, Chen CT, Wang YN, Hsu MC, Chang SS, Du Y, Ko HW, Herbst R, Hung MCClinical cancer research : an official journal of the American Association for Cancer ResearchCaspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res. 2013 Feb 15; 19(4):845-54.Clin Cancer Res2013-01-23T00:00:002013Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells.23764002Huang TH, Huo L, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH, Hung MCCancer cellEpidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell. 2013 Jun 10; 23(6):796-810.Cancer Cell2013-06-10T00:00:002013Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.24595109Chou CK, Lee HH, Tsou PH, Chen CT, Hsu JM, Yamaguchi H, Wang YN, Lee HJ, Hsu JL, Lee JF, Kameoka J, Hung MCScience signalingmMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes. Sci Signal. 2014 Mar 04; 7(315):rs1.Sci Signal2014-03-04T00:00:002014mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes.Molecular & Cellular OncologyNeuro-OncologySystems BiologyThoracic Head & Neck Medical OncologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorJOHN VICTORHEYMACHJOHN VICTOR HEYMACH9280HEYMACH, JOHN VICTORProfessorHIROHITOYAMAGUCHIHIROHITO YAMAGUCHI9388YAMAGUCHI, HIROHITOAssociate ProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessorWEIYAXIAWEIYA XIA8643XIA, WEIYAAssistant ProfessorZHIMINLUZHIMIN LU9118LU, ZHIMINProfessorCHAO-KAICHOUCHAO-KAI CHOU9113CHOU, CHAO-KAIAssistant Professor1.170820.00589486192research areas3.710750.017919510coauthor of30.95833.0943460similar to1129selected publicationsAuthorship 22719810Authorship 2304421Authorship 2304869Authorship 232182416547503Ling X, Wang Y, Dietrich MF, Andreeff M, Arlinghaus RBOncogeneVaccination with leukemia cells expressing cell-surface-associated GM-CSF blocks leukemia induction in immunocompetent mice. Oncogene. 2006 Jul 27; 25(32):4483-90.Oncogene2006-03-20T00:00:002006Vaccination with leukemia cells expressing cell-surface-associated GM-CSF blocks leukemia induction in immunocompetent mice.19526459Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MCMolecular carcinogenesisThe suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Mol Carcinog. 2009 Nov; 48(11):1048-58.Mol Carcinog2009-11-01T00:00:002009The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.21911455Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN, Hung MCCancer researchFOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011 Nov 01; 71(21):6878-87.Cancer Res2011-09-12T00:00:002011FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization.22520625Wang YN, Hung MCCell & bioscienceNuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family. Cell Biosci. 2012 Apr 20; 2(1):13.Cell Biosci2012-04-20T00:00:002012Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family.22815474Yu YL, Chou RH, Wu CH, Wang YN, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH, Hung MCThe Journal of biological chemistryNuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J Biol Chem. 2012 Sep 07; 287(37):31015-26.J Biol Chem2012-07-19T00:00:002012Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776.Authorship 2454361Authorship 2518365Authorship 258451812954631Wang YN, Chang WCThe Journal of biological chemistryInduction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun. J Biol Chem. 2003 Nov 14; 278(46):45848-57.J Biol Chem2003-09-03T00:00:002003Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun.18586824Hung LY, Tseng JT, Lee YC, Xia W, Wang YN, Wu ML, Chuang YH, Lai CH, Chang WCNucleic acids researchNuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression. Nucleic Acids Res. 2008 Aug; 36(13):4337-51.Nucleic Acids Res2008-06-27T00:00:002008Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression.23376851Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP, Wang YN, Yamaguchi H, Miller SA, Hung MCOncogeneSyntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene. 2014 Feb 06; 33(6):756-70.Oncogene2013-02-04T00:00:002013Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking.Authorship 2694845Authorship 2703831Authorship 272094221080941Jin Q, Yuan LX, Boulbes D, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJBreast cancer research : BCRFatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res. 2010; 12(6):R96.Breast Cancer Res2010-11-16T00:00:002010Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.22451678Wang YN, Lee HH, Lee HJ, Du Y, Yamaguchi H, Hung MCThe Journal of biological chemistryMembrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J Biol Chem. 2012 May 11; 287(20):16869-79.J Biol Chem2012-03-28T00:00:002012Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.25073158Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Wang HL, Kuo SC, Chen CH, Yu YL, Hung MCDevelopmental cellEGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell. 2014 Jul 28; 30(2):224-37.Dev Cell2014-07-28T00:00:002014EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.Authorship 273227116214953Wang YN, Chen YJ, Chang WCMolecular pharmacologyActivation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression. Mol Pharmacol. 2006 Jan; 69(1):85-98.Mol Pharmacol2005-10-07T00:00:002005Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression.25304351Wang YN, Huo L, Hsu JL, Hung MCMethods in molecular biology (Clifton, N.J.)Biochemical fractionation of membrane receptors in the nucleus. Methods Mol Biol. 2015; 1234:99-112.Methods Mol Biol2015-01-01T00:00:002015Biochemical fractionation of membrane receptors in the nucleus.74Professor10Assistant Professor54Instructor14Associate Professor47Distinguished Service Professor53Graduate StudentAuthorship 3740841Authorship 3741724Authorship 374174218663364Leng X, Lin H, Ding T, Wang Y, Wu Y, Klumpp S, Sun T, Zhou Y, Monaco P, Belmont J, Aderem A, Akira S, Strong R, Arlinghaus ROncogeneLipocalin 2 is required for BCR-ABL-induced tumorigenesis. Oncogene. 2008 Oct 16; 27(47):6110-9.Oncogene2008-07-28T00:00:002008Lipocalin 2 is required for BCR-ABL-induced tumorigenesis.Authorship 848227Authorship 857234Authorship 863622Journal of Clinical InvestigationPRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. Journal of Clinical Investigation. 125:4529-4543.PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab responseNuclear functions of receptor tyrosine kinases. 77-109.Nuclear functions of receptor tyrosine kinasesNuclear functions and trafficking of receptor tyrosine Kinases. 159-176.Nuclear functions and trafficking of receptor tyrosine KinasesD002467Anatomy67316190.653164Cell NucleusD009685Anatomy26390.965782Nuclear EnvelopeD004815Chemicals & Drugs1964230.855063Epidermal Growth FactorD002458Procedures55680.980493Cell FractionationDepartment of Molecular & Cellular BiologyMolecular & Cellular BiologyBaylor College of MedicineBERTO'MALLEYBERT O'MALLEY0.000000000000000.000000000000002464O'MALLEY, BERTDistinguished Service ProfessorD066246Chemicals & Drugs63422980.527591ErbB Receptors20802156Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, Hung MCProceedings of the National Academy of Sciences of the United States of AmericaRNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16125-30.Proc Natl Acad Sci U S A2010-08-27T00:00:002010RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.21258366Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MCNature cell biologyCrosstalk between Arg?1175 methylation and Tyr?1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol. 2011 Feb; 13(2):174-81.Nat Cell Biol2011-01-23T00:00:002011Crosstalk between Arg?1175 methylation and Tyr?1173 phosphorylation negatively modulates EGFR-mediated ERK activation.21487020Huang WC, Chen YJ, Li LY, Wei YL, Hsu SC, Tsai SL, Chiu PC, Huang WP, Wang YN, Chen CH, Chang WC, Chang WC, Chen AJ, Tsai CH, Hung MCThe Journal of biological chemistryNuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J Biol Chem. 2011 Jun 10; 286(23):20558-68.J Biol Chem2011-04-12T00:00:002011Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.21555369Li LY, Chen H, Hsieh YH, Wang YN, Chu HJ, Chen YH, Chen HY, Chien PJ, Ma HT, Tsai HC, Lai CC, Sher YP, Lien HC, Tsai CH, Hung MCCancer researchNuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res. 2011 Jun 15; 71(12):4269-79.Cancer Res2011-05-09T00:00:002011Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes.true1Distinguished Service ProfessorDistinguished Service ProfessorDevelopment, Disease Models & Therapeuticstrue1Graduate StudentGraduate StudentTzu-HsuanHuangTzu-Hsuan Huang18704Huang, Tzu-HsuanGraduate Studenttrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1InstructorInstructortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessor