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ZHEN FAN

TitleProfessor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1901 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang F, Zhou B, Wang R, Jenkinson J, Zhu W, Zhong J, Fan Z, Sun L. Engineering microcracks in MWCNT/elastomer bilayers for high-performance stretchable sensor development. Nanotechnology. 2023 Oct 30; 35(3). PMID: 37820636.
      Citations:    Fields:    
    2. Feng G, Shi Y, Jia H, Risal S, Yang X, Ruchhoeft P, Shih WC, Fan Z, Xu W, Shan X. Progressive and instantaneous nature of lithium nucleation discovered by dynamic and operando imaging. Sci Adv. 2023 May 24; 9(21):eadg6813. PMID: 37224260; PMCID: PMC10208563.
      Citations:    Fields:    
    3. Wu C, Emley B, Zhao L, Liang Y, Ai Q, Chen Z, Robles Hern?ndez FC, Wang F, Risal S, Guo H, Lou J, Yao Y, Fan Z. Understanding the Chemomechanical Function of the Silver-Carbon Interlayer in Sheet-type All-Solid-State Lithium-Metal Batteries. Nano Lett. 2023 May 24; 23(10):4415-4422. PMID: 37140477.
      Citations:    Fields:    
    4. Chaganty BKR, Qiu S, Lu Y, Lopez-Berestein G, Ozpolat B, Fan Z. Redirecting host preexisting influenza A virus immunity for cancer immunotherapy. Cancer Immunol Immunother. 2022 Jul; 71(7):1611-1623. PMID: 34731283; PMCID: PMC8563826.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Lu H, Lu Y, Xie Y, Qiu S, Li X, Fan Z. Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma. JCI Insight. 2019 10 03; 4(19). PMID: 31578313; PMCID: PMC6795401.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. Chaganty BKR, Qiu S, Gest A, Lu Y, Ivan C, Calin GA, Weiner LM, Fan Z. Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFN? secretion. Cancer Lett. 2018 08 28; 430:47-56. PMID: 29746929; PMCID: PMC6004098.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    7. Meng S, Wang G, Lu Y, Fan Z. Functional cooperation between HIF-1a and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR. Lung Cancer. 2018 07; 121:82-90. PMID: 29858032; PMCID: PMC6004101.
      Citations: 11     Fields:    Translation:HumansCells
    8. Tao X, Lu Y, Qiu S, Wang Y, Qin J, Fan Z. AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis. Cancer Lett. 2017 11 01; 408:33-42. PMID: 28823958; PMCID: PMC5628150.
      Citations: 15     Fields:    Translation:HumansCells
    9. Ganapathi KA, Pham TH, Xi L, Torres-Cabala CA, Nanaji NM, Zha HD, Fan Z, Irwin S, Pittaluga S, Raffeld M, Jaffe ES, Nicolae A. EBV-negative Aggressive NK-cell Leukemia/Lymphoma: Clinical, Pathologic, and Genetic Features. Am J Surg Pathol. 2017 01; 41(1):67-74. PMID: 27631517; PMCID: PMC5159195.
      Citations: 26     Fields:    Translation:Humans
    10. Lu Y, Shi C, Qiu S, Fan Z. Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells. Oncotarget. 2016 Oct 04; 7(40):64766-64777. PMID: 27074568; PMCID: PMC5323114.
      Citations: 12     Fields:    Translation:HumansCells
    11. Luo J, Hong Y, Lu Y, Qiu S, Chaganty BK, Zhang L, Wang X, Li Q, Fan Z. Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab. Cancer Lett. 2017 01 01; 384:39-49. PMID: 27693630; PMCID: PMC5110372.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    12. Lu H, Li X, Lu Y, Qiu S, Fan Z. ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer Lett. 2016 10 10; 381(1):23-30. PMID: 27450723; PMCID: PMC5017913.
      Citations: 27     Fields:    Translation:HumansCells
    13. Ai Z, Lu Y, Qiu S, Fan Z. Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism. Cancer Lett. 2016 Apr 01; 373(1):36-44. PMID: 26801746; PMCID: PMC4769873.
      Citations: 63     Fields:    Translation:HumansCells
    14. Chaganty BK, Lu Y, Qiu S, Somanchi SS, Lee DA, Fan Z. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFN? secretion. Oncoimmunology. 2016 Apr; 5(4):e1100790. PMID: 27141382; PMCID: PMC4839349.
      Citations: 23     Fields:    
    15. Li X, Lu Y, Lu H, Luo J, Hong Y, Fan Z. AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab. Oncotarget. 2015 May 10; 6(13):11507-18. PMID: 25871473; PMCID: PMC4484472.
      Citations: 23     Fields:    Translation:HumansCells
    16. Liang K, Qiu S, Lu Y, Fan Z. Autocrine/paracrine erythropoietin regulates migration and invasion potential and the stemness of human breast cancer cells. Cancer Biol Ther. 2014 Jan; 15(1):89-98. PMID: 24100272; PMCID: PMC3938527.
      Citations: 8     Fields:    Translation:HumansCells
    17. Lu H, Li X, Luo Z, Liu J, Fan Z. Cetuximab reverses the Warburg effect by inhibiting HIF-1-regulated LDH-A. Mol Cancer Ther. 2013 Oct; 12(10):2187-99. PMID: 23920275; PMCID: PMC3811007.
      Citations: 42     Fields:    Translation:HumansCells
    18. Ai M, Qiu S, Lu Y, Fan Z. HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain. Cell Signal. 2013 Sep; 25(9):1754-61. PMID: 23707532; PMCID: PMC3703634.
      Citations: 9     Fields:    Translation:HumansCells
    19. Xu J, Lu Y, Qiu S, Chen ZN, Fan Z. A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells. Cancer Lett. 2013 Jul 28; 335(2):380-6. PMID: 23474495; PMCID: PMC3927232.
      Citations: 18     Fields:    Translation:HumansCells
    20. Ai M, Liang K, Lu Y, Qiu S, Fan Z. Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition. Cancer Biol Ther. 2013 Mar; 14(3):237-45. PMID: 23291984; PMCID: PMC3595306.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    21. Bristol ML, Di X, Beckman MJ, Wilson EN, Henderson SC, Maiti A, Fan Z, Gewirtz DA. Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3. Autophagy. 2012 May 01; 8(5):739-53. PMID: 22498493; PMCID: PMC3378418.
      Citations: 58     Fields:    Translation:HumansCells
    22. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bourquin JP, Boya P, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
      Citations: 1751     Fields:    Translation:HumansAnimals
    23. Lu H, Liang K, Lu Y, Fan Z. The anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of HIF-1a. Cancer Lett. 2012 Sep 01; 322(1):78-85. PMID: 22348829; PMCID: PMC3361552.
      Citations: 25     Fields:    Translation:HumansCells
    24. Guo W, Chen D, Fan Z, Epstein HF. Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer. J Mol Biol. 2011 Sep 23; 412(3):365-78. PMID: 21802425.
      Citations: 16     Fields:    Translation:HumansCells
    25. Wu Y, Li X, Zhu JX, Xie W, Le W, Fan Z, Jankovic J, Pan T. Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease. Neurosignals. 2011; 19(3):163-74. PMID: 21778691; PMCID: PMC3699815.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    26. Luwor RB, Lu Y, Li X, Liang K, Fan Z. Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib. Cancer Lett. 2011 Jul 01; 306(1):85-91. PMID: 21411223; PMCID: PMC3102794.
      Citations: 6     Fields:    Translation:HumansCells
    27. Zhang G, Brewster A, Guan B, Fan Z, Brown PH, Xu XC. Tumor-suppressor activity of RRIG1 in breast cancer. BMC Cancer. 2011 Jan 25; 11:32. PMID: 21266059; PMCID: PMC3037341.
      Citations: 2     Fields:    Translation:HumansCells
    28. Lu Y, Li X, Lu H, Fan Z. 1, 9-Pyrazoloanthrones downregulate HIF-1a and sensitize cancer cells to cetuximab-mediated anti-EGFR therapy. PLoS One. 2010 Dec 29; 5(12):e15823. PMID: 21209911; PMCID: PMC3012113.
      Citations: 13     Fields:    Translation:HumansCells
    29. Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 2010 Nov 16; 18(5):423-35. PMID: 21075308; PMCID: PMC3022383.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    30. Li X, Lu Y, Pan T, Fan Z. Roles of autophagy in cetuximab-mediated cancer therapy against EGFR. Autophagy. 2010 Nov; 6(8):1066-77. PMID: 20864811; PMCID: PMC3039478.
      Citations: 47     Fields:    Translation:HumansCells
    31. Li X, Fan Z. The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex. Cancer Res. 2010 Jul 15; 70(14):5942-52. PMID: 20634405; PMCID: PMC2933174.
      Citations: 88     Fields:    Translation:HumansCells
    32. Chen M, Gu J, Delclos GL, Killary AM, Fan Z, Hildebrandt MA, Chamberlain RM, Grossman HB, Dinney CP, Wu X. Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients. Carcinogenesis. 2010 Aug; 31(8):1387-91. PMID: 20530239; PMCID: PMC2915631.
      Citations: 29     Fields:    Translation:Humans
    33. Giordano RJ, Sidman RL, Bronk LF, Fan Z, Mendelsohn J, Arap W, Pasqualini R, Card?-Vila M. From combinatorial peptide selection to drug prototype (II): targeting the epidermal growth factor receptor pathway. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5118-23. PMID: 20190183; PMCID: PMC2841862.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    34. Chen M, Cassidy A, Gu J, Delclos GL, Zhen F, Yang H, Hildebrandt MA, Lin J, Ye Y, Chamberlain RM, Dinney CP, Wu X. Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk. Carcinogenesis. 2009 Dec; 30(12):2047-52. PMID: 19875696; PMCID: PMC2792319.
      Citations: 38     Fields:    Translation:Humans
    35. Cunningham MP, Thomas H, Marks C, Green M, Fan Z, Modjtahedi H. Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells. Int J Oncol. 2008 Nov; 33(5):1107-13. PMID: 18949375.
      Citations: 19     Fields:    Translation:HumansCells
    36. Li X, Lu Y, Liang K, Pan T, Mendelsohn J, Fan Z. Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab. Mol Cancer Ther. 2008 May; 7(5):1207-17. PMID: 18483308.
      Citations: 37     Fields:    Translation:HumansCells
    37. Lu Y, Liang K, Li X, Fan Z. Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha. Mol Cancer. 2007 Oct 11; 6:63. PMID: 17931419; PMCID: PMC2117021.
      Citations: 32     Fields:    Translation:HumansCells
    38. Lu Y, Li X, Liang K, Luwor R, Siddik ZH, Mills GB, Mendelsohn J, Fan Z. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Cancer Res. 2007 Sep 01; 67(17):8240-7. PMID: 17804738.
      Citations: 79     Fields:    Translation:HumansCells
    39. Adams KE, Ke S, Kwon S, Liang F, Fan Z, Lu Y, Hirschi K, Mawad ME, Barry MA, Sevick-Muraca EM. Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer. J Biomed Opt. 2007 Mar-Apr; 12(2):024017. PMID: 17477732.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    40. Cunningham MP, Thomas H, Fan Z, Modjtahedi H. Responses of human colorectal tumor cells to treatment with the anti-epidermal growth factor receptor monoclonal antibody ICR62 used alone and in combination with the EGFR tyrosine kinase inhibitor gefitinib. Cancer Res. 2006 Aug 01; 66(15):7708-15. PMID: 16885373.
      Citations: 20     Fields:    Translation:HumansCells
    41. Liang K, Lu Y, Li X, Zeng X, Glazer RI, Mills GB, Fan Z. Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Mol Pharmacol. 2006 Sep; 70(3):1045-52. PMID: 16782806.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    42. Li X, Lu Y, Jin W, Liang K, Mills GB, Fan Z. Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity. J Biol Chem. 2006 May 12; 281(19):13837-13843. PMID: 16549426.
      Citations: 12     Fields:    Translation:HumansCells
    43. Luwor RB, Lu Y, Li X, Mendelsohn J, Fan Z. The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression. Oncogene. 2005 Jun 23; 24(27):4433-41. PMID: 15806152.
      Citations: 46     Fields:    Translation:HumansCells
    44. Zhang L, Zhu H, Teraishi F, Davis JJ, Guo W, Fan Z, Fang B. Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line. Neoplasia. 2005 Jun; 7(6):594-602. PMID: 16036110; PMCID: PMC1501285.
      Citations: 15     Fields:    Translation:HumansCells
    45. Li X, Lu Y, Liang K, Liu B, Fan Z. Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells. Breast Cancer Res. 2005; 7(5):R589-97. PMID: 16168102; PMCID: PMC1242125.
      Citations: 36     Fields:    Translation:HumansCells
    46. Nakata E, Hunter N, Mason K, Fan Z, Ang KK, Milas L. C225 antiepidermal growth factor receptor antibody enhances the efficacy of docetaxel chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1163-73. PMID: 15234052.
      Citations: 10     Fields:    Translation:HumansAnimals
    47. Andratschke NH, Dittmann KH, Mason KA, Fan Z, Liao Z, Komaki R, Ang KK, Milas L. Epidermal growth factor receptor as a target to improve treatment of lung cancer. Clin Lung Cancer. 2004 May; 5(6):340-52. PMID: 15217533.
      Citations: 2     Fields:    Translation:HumansCells
    48. Milas L, Fan Z, Andratschke NH, Ang KK. Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies. Int J Radiat Oncol Biol Phys. 2004 Mar 01; 58(3):966-71. PMID: 14967457.
      Citations: 47     Fields:    Translation:AnimalsCells
    49. Liang K, Lu Y, Jin W, Ang KK, Milas L, Fan Z. Sensitization of breast cancer cells to radiation by trastuzumab. Mol Cancer Ther. 2003 Nov; 2(11):1113-20. PMID: 14617784.
      Citations: 91     Fields:    Translation:HumansCells
    50. Liang K, Ang KK, Milas L, Hunter N, Fan Z. The epidermal growth factor receptor mediates radioresistance. Int J Radiat Oncol Biol Phys. 2003 Sep 01; 57(1):246-54. PMID: 12909240.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    51. Knuefermann C, Lu Y, Liu B, Jin W, Liang K, Wu L, Schmidt M, Mills GB, Mendelsohn J, Fan Z. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene. 2003 May 22; 22(21):3205-12. PMID: 12761490.
      Citations: 168     Fields:    Translation:HumansCells
    52. Vega J, Ke S, Fan Z, Wallace S, Charsangavej C, Li C. Targeting doxorubicin to epidermal growth factor receptors by site-specific conjugation of C225 to poly(L-glutamic acid) through a polyethylene glycol spacer. Pharm Res. 2003 May; 20(5):826-32. PMID: 12751641.
      Citations: 11     Fields:    Translation:HumansCells
    53. Liang K, Jin W, Knuefermann C, Schmidt M, Mills GB, Ang KK, Milas L, Fan Z. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Mol Cancer Ther. 2003 Apr; 2(4):353-60. PMID: 12700279.
      Citations: 34     Fields:    Translation:HumansCells
    54. Sclabas GM, Fujioka S, Schmidt C, Fan Z, Evans DB, Chiao PJ. Restoring apoptosis in pancreatic cancer cells by targeting the nuclear factor-kappaB signaling pathway with the anti-epidermal growth factor antibody IMC-C225. J Gastrointest Surg. 2003 Jan; 7(1):37-43; discussion 43. PMID: 12559183.
      Citations: 13     Fields:    Translation:HumansCells
    55. Sweeney P, Karashima T, Kim SJ, Kedar D, Mian B, Huang S, Baker C, Fan Z, Hicklin DJ, Pettaway CA, Dinney CP. Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production. Clin Cancer Res. 2002 Aug; 8(8):2714-24. PMID: 12171905.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    56. Liu B, Peng D, Lu Y, Jin W, Fan Z. A novel single amino acid deletion caspase-8 mutant in cancer cells that lost proapoptotic activity. J Biol Chem. 2002 Aug 16; 277(33):30159-64. PMID: 12055196.
      Citations: 6     Fields:    Translation:Cells
    57. Karashima T, Sweeney P, Slaton JW, Kim SJ, Kedar D, Izawa JI, Fan Z, Pettaway C, Hicklin DJ, Shuin T, Dinney CP. Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice. Clin Cancer Res. 2002 May; 8(5):1253-64. PMID: 12006546.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    58. Patrick CW, Zheng B, Schmidt M, Herman PS, Chauvin BP, Fan Z, Stark B, Evans GR. Dermal fibroblasts genetically engineered to release nerve growth factor. Ann Plast Surg. 2001 Dec; 47(6):660-5. PMID: 11756838.
      Citations: 3     Fields:    Translation:AnimalsCells
    59. Schmidt M, Lu Y, Parant JM, Lozano G, Bacher G, Beckers T, Fan Z. Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies. Mol Pharmacol. 2001 Nov; 60(5):900-6. PMID: 11641417.
      Citations: 11     Fields:    Translation:HumansCells
    60. Nasu S, Ang KK, Fan Z, Milas L. C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability. Int J Radiat Oncol Biol Phys. 2001 Oct 01; 51(2):474-7. PMID: 11567823.
      Citations: 23     Fields:    Translation:HumansAnimals
    61. Liu B, Fang M, Lu Y, Mills GB, Fan Z. Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells. Br J Cancer. 2001 Jul 20; 85(2):303-11. PMID: 11461094; PMCID: PMC2364054.
      Citations: 16     Fields:    Translation:HumansCells
    62. Wen X, Wu QP, Lu Y, Fan Z, Charnsangavej C, Wallace S, Chow D, Li C. Poly(ethylene glycol)-conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains. Bioconjug Chem. 2001 Jul-Aug; 12(4):545-53. PMID: 11459459.
      Citations: 4     Fields:    Translation:HumansCells
    63. Wang L, Liu B, Schmidt M, Lu Y, Wels W, Fan Z. Antitumor effect of an HER2-specific antibody-toxin fusion protein on human prostate cancer cells. Prostate. 2001 Apr; 47(1):21-8. PMID: 11304726.
      Citations: 6     Fields:    Translation:AnimalsCells
    64. Schmidt M, McWatters A, White RA, Groner B, Wels W, Fan Z, Bast RC. Synergistic interaction between an anti-p185HER-2 pseudomonas exotoxin fusion protein [scFv(FRP5)-ETA] and ionizing radiation for inhibiting growth of ovarian cancer cells that overexpress HER-2. Gynecol Oncol. 2001 Feb; 80(2):145-55. PMID: 11161852.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    65. Milas L, Mason K, Hunter N, Petersen S, Yamakawa M, Ang K, Mendelsohn J, Fan Z. In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res. 2000 Feb; 6(2):701-8. PMID: 10690556.
      Citations: 110     Fields:    Translation:HumansAnimals
    66. Fang M, Liu B, Schmidt M, Lu Y, Mendelsohn J, Fan Z. Involvement of p21Waf1 in mediating inhibition of paclitaxel-induced apoptosis by epidermal growth factor in MDA-MB-468 human breast cancer cells. Anticancer Res. 2000 Jan-Feb; 20(1A):103-11. PMID: 10769641.
      Citations: 2     Fields:    Translation:HumansCells
    67. Ye D, Mendelsohn J, Fan Z. Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. Clin Cancer Res. 1999 Aug; 5(8):2171-7. PMID: 10473102.
      Citations: 16     Fields:    Translation:HumansCells
    68. Chou JL, Fan Z, DeBlasio T, Koff A, Rosen N, Mendelsohn J. Constitutive overexpression of cyclin D1 in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor. Breast Cancer Res Treat. 1999 Jun; 55(3):267-83. PMID: 10517171.
      Citations: 9     Fields:    Translation:HumansCells
    69. Bianco R, Damiano V, De Lorenzo S, Pepe S, De Placido S, Fan Z, Mendelsohn J, Bianco AR, Tortora G, Ciardiello F. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin Cancer Res. 1999 Apr; 5(4):909-16. PMID: 10213228.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    70. Ye D, Mendelsohn J, Fan Z. Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225. Oncogene. 1999 Jan 21; 18(3):731-8. PMID: 9989823.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    71. Bromberg JF, Fan Z, Brown C, Mendelsohn J, Darnell JE. Epidermal growth factor-induced growth inhibition requires Stat1 activation. Cell Growth Differ. 1998 Jul; 9(7):505-12. PMID: 9690618.
      Citations: 24     Fields:    Translation:HumansCells
    72. Fan Z, Mendelsohn J. Therapeutic application of anti-growth factor receptor antibodies. Curr Opin Oncol. 1998 Jan; 10(1):67-73. PMID: 9466487.
      Citations: 12     Fields:    Translation:HumansAnimals
    73. Fan Z, Shang BY, Lu Y, Chou JL, Mendelsohn J. Reciprocal changes in p27(Kip1) and p21(Cip1) in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors. Clin Cancer Res. 1997 Nov; 3(11):1943-8. PMID: 9815583.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    74. Mendelsohn J, Fan Z. Epidermal growth factor receptor family and chemosensitization. J Natl Cancer Inst. 1997 Mar 05; 89(5):341-3. PMID: 9060954.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    75. Peng D, Fan Z, Lu Y, DeBlasio T, Scher H, Mendelsohn J. Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res. 1996 Aug 15; 56(16):3666-9. PMID: 8706005.
      Citations: 49     Fields:    Translation:HumansCells
    76. Wu X, Rubin M, Fan Z, DeBlasio T, Soos T, Koff A, Mendelsohn J. Involvement of p27KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene. 1996 Apr 04; 12(7):1397-403. PMID: 8622855.
      Citations: 36     Fields:    Translation:HumansCells
    77. Fan Z, Lu Y, Wu X, DeBlasio A, Koff A, Mendelsohn J. Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. J Cell Biol. 1995 Oct; 131(1):235-42. PMID: 7559780; PMCID: PMC2120589.
      Citations: 26     Fields:    Translation:HumansCells
    78. Wu X, Fan Z, Masui H, Rosen N, Mendelsohn J. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest. 1995 Apr; 95(4):1897-905. PMID: 7706497; PMCID: PMC295734.
      Citations: 79     Fields:    Translation:HumansCells
    79. Fan Z, Lu Y, Wu X, Mendelsohn J. Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem. 1994 Nov 04; 269(44):27595-602. PMID: 7961676.
      Citations: 61     Fields:    Translation:HumansCells
    80. Fan Z, Mendelsohn J, Masui H, Kumar R. Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies. J Biol Chem. 1993 Oct 05; 268(28):21073-9. PMID: 8407944.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    81. Fan Z, Baselga J, Masui H, Mendelsohn J. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res. 1993 Oct 01; 53(19):4637-42. PMID: 8402640.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    82. Fan Z, Masui H, Altas I, Mendelsohn J. Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res. 1993 Sep 15; 53(18):4322-8. PMID: 8364927.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    83. Fan Z, Tang Z, Liu K, Zhou D, Lu J, Yuan A, Zhao H. Radioiodinated anti-hepatocellular carcinoma (HCC) ferritin. Targeting therapy, tumor imaging and anti-antibody response in HCC patients with hepatic arterial infusion. J Cancer Res Clin Oncol. 1992; 118(5):371-6. PMID: 1316355.
      Citations: 3     Fields:    Translation:Humans
    84. Detection of anti-antibody in serum of patient with hepatocellular carcinoma following radioimmunotherapy. Acta Academiae Medicinae Shanghai. 17:451-453.
    85. AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab. Oncotarget. 6:11507-11518.
    86. ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer Letters. 381:23-30.
    87. Radioimmunoimaging of primary liver cancer in patients with 131I labeled anti-human hepatocellular carcinoma isoferritin antibody. Acta Academiae Medicinae Shanghai. 17:405-408.
    88. Trastuzumab upregulates expression of HLA-ABC and T cell costimulatory molecules through engagement of natural killer cells and stimulation of IFNγ secretion. OncoImmunology. 5.
    89. Role of AKT in chemotherapy-mediated cytotoxicity in MCF-7 breast cancer cells. Breast Cancer Research and Treatment. 69:275.
    90. Factors influencing the effect of radioimmunotherapy on liver cancer. Chinese Journal of Cancer Research. 4:55-60.
    91. A decade's studies on the immunotargeting therapy of hepatocellular carcinoma. Antibody, Immunoconjugates, and Radiopharmaceuticals. 6:155-165.
    92. Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism. Cancer Letters. 373:36-44.
    93. Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab. Cancer Letters. 384:39-49.
    94. Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells. Oncotarget. 7:64766-64777.
    95. Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers. British Journal of Cancer. 113:1010-1019.
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