SHARON RDENTSHARON R DENT8542DENT, SHARON RProfessorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson21285357Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SYThe Journal of biological chemistryProtein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem. 2011 Apr 08; 286(14):12234-44.J Biol Chem2011-02-01T00:00:002011Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.25417107Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi XCellAF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Cell. 2014 Oct 23; 159(3):558-71.Cell2014-10-23T00:00:002014AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation.25877919Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SYGenes & developmentMyc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev. 2015 Apr 15; 29(8):803-16.Genes Dev2015-04-15T00:00:002015Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.PO Box 389Smithville78957-0389TXAuthorship 163806Authorship 164322Authorship 164662Authorship 164665Authorship 165508Authorship 165560Authorship 1656424Authorship 166174Authorship 166467Authorship 166626Authorship 167047Authorship 168853Authorship 169079Authorship 1699576Authorship 1706132Authorship 1714333Authorship 1723474Authorship 1725923Authorship 1728936Authorship 1742964Authorship 1745032Authorship 1757732Authorship 178307Authorship 1801502Authorship 1815706Authorship 1850632Authorship 1875145Authorship 1883943Authorship 1892557Authorship 1916588Authorship 1917572Authorship 1921277Authorship 1941123Authorship 194441135280Jacobson MK, Barton RA, Yoder SS, Sigh S, Lyle RECancer lettersMutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative. Cancer Lett. 1979 Feb; 6(2):83-7.Cancer Lett1979-02-01T00:00:001979Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative.8341604Murphy MR, Shimizu M, Roth SY, Dranginis AM, Simpson RTNucleic acids researchDNA-protein interactions at the S.cerevisiae alpha 2 operator in vivo. Nucleic Acids Res. 1993 Jul 11; 21(14):3295-300.Nucleic Acids Res1993-07-11T00:00:001993DNA-protein interactions at the S.cerevisiae alpha 2 operator in vivo.8675011Edmondson DG, Smith MM, Roth SYGenes & developmentRepression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes Dev. 1996 May 15; 10(10):1247-59.Genes Dev1996-05-15T00:00:001996Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.8751719Edmondson DG, Roth SYFASEB journal : official publication of the Federation of American Societies for Experimental BiologyChromatin and transcription. FASEB J. 1996 Aug; 10(10):1173-82.FASEB J1996-08-01T00:00:001996Chromatin and transcription.8858142Roth SY, Allis CDCellHistone acetylation and chromatin assembly: a single escort, multiple dances? Cell. 1996 Oct 04; 87(1):5-8.Cell1996-10-04T00:00:001996Histone acetylation and chromatin assembly: a single escort, multiple dances?10384310Edmondson DG, Zhang W, Watson A, Xu W, Bone JR, Yu Y, Stillman D, Roth SYCold Spring Harbor symposia on quantitative biologyIn vivo functions of histone acetylation/deacetylation in Tup1p repression and Gcn5p activation. Cold Spring Harb Symp Quant Biol. 1998; 63:459-68.Cold Spring Harb Symp Quant Biol1998-01-01T00:00:001998In vivo functions of histone acetylation/deacetylation in Tup1p repression and Gcn5p activation.11056171Bone JR, Roth SYThe Journal of biological chemistryRecruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation. J Biol Chem. 2001 Jan 19; 276(3):1808-13.J Biol Chem2000-10-30T00:00:002000Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation.11395403Roth SY, Denu JM, Allis CDAnnual review of biochemistryHistone acetyltransferases. Annu Rev Biochem. 2001; 70:81-120.Annu Rev Biochem2001-01-01T00:00:002001Histone acetyltransferases.11784848Davie JK, Trumbly RJ, Dent SYMolecular and cellular biologyHistone-dependent association of Tup1-Ssn6 with repressed genes in vivo. Mol Cell Biol. 2002 Feb; 22(3):693-703.Mol Cell Biol2002-02-01T00:00:002002Histone-dependent association of Tup1-Ssn6 with repressed genes in vivo.12039950Edmondson DG, Davie JK, Zhou J, Mirnikjoo B, Tatchell K, Dent SYThe Journal of biological chemistrySite-specific loss of acetylation upon phosphorylation of histone H3. J Biol Chem. 2002 Aug 16; 277(33):29496-502.J Biol Chem2002-05-30T00:00:002002Site-specific loss of acetylation upon phosphorylation of histone H3.12637515Mukai Y, Davie JK, Dent SYThe Journal of biological chemistryPhysical and functional interaction of the yeast corepressor Tup1 with mRNA 5'-triphosphatase. J Biol Chem. 2003 May 23; 278(21):18895-901.J Biol Chem2003-03-13T00:00:002003Physical and functional interaction of the yeast corepressor Tup1 with mRNA 5'-triphosphatase.12660246Liu X, Tesfai J, Evrard YA, Dent SY, Martinez EThe Journal of biological chemistryc-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. J Biol Chem. 2003 May 30; 278(22):20405-12.J Biol Chem2003-03-26T00:00:002003c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation.14525981Davie JK, Edmondson DG, Coco CB, Dent SYThe Journal of biological chemistryTup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem. 2003 Dec 12; 278(50):50158-62.J Biol Chem2003-10-02T00:00:002003Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo.16173079Zhang K, Dent SYJournal of cellular biochemistryHistone modifying enzymes and cancer: going beyond histones. J Cell Biochem. 2005 Dec 15; 96(6):1137-48.J Cell Biochem2005-12-15T00:00:002005Histone modifying enzymes and cancer: going beyond histones.16483927Davie JK, Dent SYMolecular cellNo Spt6, no nucleosomes, no activator required. Mol Cell. 2006 Feb 17; 21(4):452-3.Mol Cell2006-02-17T00:00:002006No Spt6, no nucleosomes, no activator required.17466618Chosed R, Dent SYMolecular cellA two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila. Mol Cell. 2007 Apr 27; 26(2):160-2.Mol Cell2007-04-27T00:00:002007A two-way street: LSD1 regulates chromatin boundary formation in S. pombe and Drosophila.18265194Edmondson DG, Roth SYCurrent protocols in molecular biologyIdentification of protein interactions by far Western analysis. Curr Protoc Mol Biol. 2001 Aug; Chapter 20:Unit 20.6.Curr Protoc Mol Biol2001-08-01T00:00:002001Identification of protein interactions by far Western analysis.19498464Loyola A, Tagami H, Bonaldi T, Roche D, Quivy JP, Imhof A, Nakatani Y, Dent SY, Almouzni GEMBO reportsThe HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep. 2009 Jul; 10(7):769-75.EMBO Rep2009-06-05T00:00:002009The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.21745819Kim E, Napierala M, Dent SYNucleic acids researchHyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia. Nucleic Acids Res. 2011 Oct; 39(19):8366-77.Nucleic Acids Res2011-07-10T00:00:002011Hyperexpansion of GAA repeats affects post-initiation steps of FXN transcription in Friedreich's ataxia.22955932Butler JS, Dent SYNature structural & molecular biologyChromatin 'resetting' during transcription elongation: a central role for methylated H3K36. Nat Struct Mol Biol. 2012 Sep; 19(9):863-4.Nat Struct Mol Biol2012-09-01T00:00:002012Chromatin 'resetting' during transcription elongation: a central role for methylated H3K36.23233240Polak U, McIvor E, Dent SY, Wells RD, Napierala MBioFactors (Oxford, England)Expanded complexity of unstable repeat diseases. Biofactors. 2013 Mar-Apr; 39(2):164-75.Biofactors2012-12-11T00:00:002012Expanded complexity of unstable repeat diseases.25024434Stilling RM, R?nicke R, Benito E, Urbanke H, Capece V, Burkhardt S, Bahari-Javan S, Barth J, Sananbenesi F, Sch?tz AL, Dyczkowski J, Martinez-Hernandez A, Kerimoglu C, Dent SY, Bonn S, Reymann KG, Fischer AThe EMBO journalK-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J. 2014 Sep 01; 33(17):1912-27.EMBO J2014-07-14T00:00:002014K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.Epigenetics & Molecular CarcinogenesisExperimental Radiation OncologyMolecular & Cellular OncologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorBOYKOATANASSOVBOYKO ATANASSOV9391ATANASSOV, BOYKOAssistant ProfessorYUELUYUE LU9586LU, YUEAssistant ProfessorTAIPINGCHENTAIPING CHEN9765CHEN, TAIPINGAssociate ProfessorBLAINEBARTHOLOMEWBLAINE BARTHOLOMEW9892BARTHOLOMEW, BLAINEProfessorMARK TBEDFORDMARK T BEDFORD8896BEDFORD, MARK TProfessorJUNJIECHENJUNJIE CHEN8830CHEN, JUNJIEProfessorMICHELLEBARTONMICHELLE BARTON8894BARTON, MICHELLEProfessorEVANGELIAKOUTELOUEVANGELIA KOUTELOU9559KOUTELOU, EVANGELIAInstructor6.557940.00463229552research areas4.492780.0065008327coauthor of109.60519.63560similar to11151selected publicationsAuthorship 212061Authorship 212193Authorship 2129553Authorship 2143431Authorship 2147881Authorship 215994Authorship 216256Authorship 217486Authorship 217658Authorship 217954Authorship 218384Authorship 2207126Authorship 2211949Authorship 2239656Authorship 225888Authorship 22591310Authorship 2259767Authorship 2259782Authorship 2272355Authorship 2292953Authorship 2301552Authorship 2313265Authorship 2322792Authorship 2341711Authorship 2354371412698Roth SY, Allis CDTrends in biochemical sciencesChromatin condensation: does histone H1 dephosphorylation play a role? Trends Biochem Sci. 1992 Mar; 17(3):93-8.Trends Biochem Sci1992-03-01T00:00:001992Chromatin condensation: does histone H1 dephosphorylation play a role?1547940Roth SY, Shimizu M, Johnson L, Grunstein M, Simpson RTGenes & developmentStable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4. Genes Dev. 1992 Mar; 6(3):411-25.Genes Dev1992-03-01T00:00:001992Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4.1779859Roth SY, Simpson RTMethods in cell biologyYeast minichromosomes. Methods Cell Biol. 1991; 35:289-314.Methods Cell Biol1991-01-01T00:00:001991Yeast minichromosomes.2065655Roth SY, Collini MP, Draetta G, Beach D, Allis CDThe EMBO journalA cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena. EMBO J. 1991 Aug; 10(8):2069-75.EMBO J1991-08-01T00:00:001991A cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena.7613085Roth SYCurrent opinion in genetics & developmentChromatin-mediated transcriptional repression in yeast. Curr Opin Genet Dev. 1995 Apr; 5(2):168-73.Curr Opin Genet Dev1995-04-01T00:00:001995Chromatin-mediated transcriptional repression in yeast.8782807Roth SYNature geneticsSomething about silencing. Nat Genet. 1996 Sep; 14(1):3-4.Nat Genet1996-09-01T00:00:001996Something about silencing.9092635Macatee T, Jiang YW, Stillman DJ, Roth SYNucleic acids researchGlobal alterations in chromatin accessibility associated with loss of SIN4 function. Nucleic Acids Res. 1997 Mar 15; 25(6):1240-7.Nucleic Acids Res1997-03-15T00:00:001997Global alterations in chromatin accessibility associated with loss of SIN4 function.9606197Zhang W, Bone JR, Edmondson DG, Turner BM, Roth SYThe EMBO journalEssential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. EMBO J. 1998 Jun 01; 17(11):3155-67.EMBO J1998-06-01T00:00:001998Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase.9740723Edmondson DG, Roth SYMethods (San Diego, Calif.)Interactions of transcriptional regulators with histones. Methods. 1998 Aug; 15(4):355-64.Methods1998-08-01T00:00:001998Interactions of transcriptional regulators with histones.10567571Mukai Y, Matsuo E, Roth SY, Harashima SMolecular and cellular biologyConservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog. Mol Cell Biol. 1999 Dec; 19(12):8461-8.Mol Cell Biol1999-12-01T00:00:001999Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog.11017084Xu W, Edmondson DG, Evrard YA, Wakamiya M, Behringer RR, Roth SYNature geneticsLoss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet. 2000 Oct; 26(2):229-32.Nat Genet2000-10-01T00:00:002000Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.11190575Bone JR, Roth SYCurrent topics in microbiology and immunologyCorepressor proteins and control of transcription in yeast. Curr Top Microbiol Immunol. 2001; 254:59-78.Curr Top Microbiol Immunol2001-01-01T00:00:002001Corepressor proteins and control of transcription in yeast.12724231Yu Y, Fujii S, Yuan J, Luo RZ, Wang L, Bao J, Kadota M, Oshimura M, Dent SR, Issa JP, Bast RCAnnals of the New York Academy of SciencesEpigenetic regulation of ARHI in breast and ovarian cancer cells. Ann N Y Acad Sci. 2003 Mar; 983:268-77.Ann N Y Acad Sci2003-03-01T00:00:002003Epigenetic regulation of ARHI in breast and ovarian cancer cells.12874100Fujii S, Luo RZ, Yuan J, Kadota M, Oshimura M, Dent SR, Kondo Y, Issa JP, Bast RC, Yu YHuman molecular geneticsReactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum Mol Genet. 2003 Aug 01; 12(15):1791-800.Hum Mol Genet2003-08-01T00:00:002003Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation.17440986Lin W, Srajer G, Evrard YA, Phan HM, Furuta Y, Dent SYDevelopmental dynamics : an official publication of the American Association of AnatomistsDevelopmental potential of Gcn5(-/-) embryonic stem cells in vivo and in vitro. Dev Dyn. 2007 Jun; 236(6):1547-57.Dev Dyn2007-06-01T00:00:002007Developmental potential of Gcn5(-/-) embryonic stem cells in vivo and in vitro.17643370Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto EMolecular cellHDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007 Jul 20; 27(2):197-213.Mol Cell2007-07-20T00:00:002007HDAC6 modulates cell motility by altering the acetylation level of cortactin.18228338Edmondson DG, Roth SYCurrent protocols in cell biologyIdentification of protein interactions by far Western analysis. Curr Protoc Cell Biol. 2001 May; Chapter 17:Unit 17.2.Curr Protoc Cell Biol2001-05-01T00:00:002001Identification of protein interactions by far Western analysis.18330926Lin W, Zhang Z, Srajer G, Chen YC, Huang M, Phan HM, Dent SYDevelopmental dynamics : an official publication of the American Association of AnatomistsProper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn. 2008 Apr; 237(4):928-40.Dev Dyn2008-04-01T00:00:002008Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos.18334486Riefler GM, Dent SY, Schumacher JMThe Journal of biological chemistryTousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo. J Biol Chem. 2008 May 09; 283(19):12763-8.J Biol Chem2008-03-10T00:00:002008Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo.18430026Lin W, Zhang Z, Chen CH, Behringer RR, Dent SYDevelopment, growth & differentiationProper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton. Dev Growth Differ. 2008 Jun; 50(5):321-30.Dev Growth Differ2008-04-22T00:00:002008Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton.20974139Atanassov BS, Koutelou E, Dent SYFEBS lettersThe role of deubiquitinating enzymes in chromatin regulation. FEBS Lett. 2011 Jul 07; 585(13):2016-23.FEBS Lett2010-10-26T00:00:002010The role of deubiquitinating enzymes in chromatin regulation.21779003Atanassov BS, Dent SYEMBO reportsUSP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1. EMBO Rep. 2011 Sep 01; 12(9):924-30.EMBO Rep2011-09-01T00:00:002011USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1.22370855Polak U, Hirsch C, Ku S, Gottesfeld J, Dent SY, Napierala MJournal of visualized experiments : JoVESelecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts. J Vis Exp. 2012 Feb 20; (60).J Vis Exp2012-02-20T00:00:002012Selecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts.23375745Johnson DG, Dent SYCellChromatin: receiver and quarterback for cellular signals. Cell. 2013 Feb 14; 152(4):685-9.Cell2013-01-31T00:00:002013Chromatin: receiver and quarterback for cellular signals.23795303Dent SY, Chandra JeLifeThe lasting influence of LSD1 in the blood. Elife. 2013 Jun 18; 2:e00963.Elife2013-06-18T00:00:002013The lasting influence of LSD1 in the blood.Authorship 235605Authorship 239592Authorship 240490Authorship 241062Authorship 242720Authorship 243661Authorship 243806Authorship 2441702Authorship 2456622Authorship 246181Authorship 24659910Authorship 2476531Authorship 2486075Authorship 2487092Authorship 2495484Authorship 2509344Authorship 2516692Authorship 2516813Authorship 2528147Authorship 2557955Authorship 2570057Authorship 2572003Authorship 2578985Authorship 2589103Authorship 26125881508199Morse RH, Roth SY, Simpson RTMolecular and cellular biologyA transcriptionally active tRNA gene interferes with nucleosome positioning in vivo. Mol Cell Biol. 1992 Sep; 12(9):4015-25.Mol Cell Biol1992-09-01T00:00:001992A transcriptionally active tRNA gene interferes with nucleosome positioning in vivo.7926740Cooper JP, Roth SY, Simpson RTGenes & developmentThe global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure. Genes Dev. 1994 Jun 15; 8(12):1400-10.Genes Dev1994-06-15T00:00:001994The global transcriptional regulators, SSN6 and TUP1, play distinct roles in the establishment of a repressive chromatin structure.8601308Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CDCellTetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell. 1996 Mar 22; 84(6):843-51.Cell1996-03-22T00:00:001996Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.9742083Xu W, Edmondson DG, Roth SYMolecular and cellular biologyMammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol. 1998 Oct; 18(10):5659-69.Mol Cell Biol1998-10-01T00:00:001998Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates.11114326Roth DB, Roth SYCellUnequal access: regulating V(D)J recombination through chromatin remodeling. Cell. 2000 Nov 22; 103(5):699-702.Cell2000-11-22T00:00:002000Unequal access: regulating V(D)J recombination through chromatin remodeling.11250138Marmorstein R, Roth SYCurrent opinion in genetics & developmentHistone acetyltransferases: function, structure, and catalysis. Curr Opin Genet Dev. 2001 Apr; 11(2):155-61.Curr Opin Genet Dev2001-04-01T00:00:002001Histone acetyltransferases: function, structure, and catalysis.11259576Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KSMolecular and cellular biologyThe growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol. 2001 Apr; 21(7):2259-68.Mol Cell Biol2001-04-01T00:00:002001The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.11818080Davie JK, Dent SYCurrent biology : CBTranscriptional control: an activating role for arginine methylation. Curr Biol. 2002 Jan 22; 12(2):R59-61.Curr Biol2002-01-22T00:00:002002Transcriptional control: an activating role for arginine methylation.14975250Davie JK, Dent SYCurrent topics in developmental biologyHistone modifications in corepressor functions. Curr Top Dev Biol. 2004; 59:145-63.Curr Top Dev Biol2004-01-01T00:00:002004Histone modifications in corepressor functions.15157517Roth SY, Allis CDTrends in cell biologyThe subunit-exchange model of histone acetylation. Trends Cell Biol. 1996 Oct; 6(10):371-5.Trends Cell Biol1996-10-01T00:00:001996The subunit-exchange model of histone acetylation.16143104Zhang K, Lin W, Latham JA, Riefler GM, Schumacher JM, Chan C, Tatchell K, Hawke DH, Kobayashi R, Dent SYCellThe Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell. 2005 Sep 09; 122(5):723-34.Cell2005-09-09T00:00:002005The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation.16329992Tripic T, Edmondson DG, Davie JK, Strahl BD, Dent SYBiochemical and biophysical research communicationsThe Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Biochem Biophys Res Commun. 2006 Jan 20; 339(3):905-14.Biochem Biophys Res Commun2005-11-28T00:00:002005The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation.16503130Lin W, Dent SYCurrent opinion in genetics & developmentFunctions of histone-modifying enzymes in development. Curr Opin Genet Dev. 2006 Apr; 16(2):137-42.Curr Opin Genet Dev2006-02-28T00:00:002006Functions of histone-modifying enzymes in development.16936817Malav? TM, Dent SYBiochemistry and cell biology = Biochimie et biologie cellulaireTranscriptional repression by Tup1-Ssn6. Biochem Cell Biol. 2006 Aug; 84(4):437-43.Biochem Cell Biol2006-08-01T00:00:002006Transcriptional repression by Tup1-Ssn6.17325035Bu P, Evrard YA, Lozano G, Dent SYMolecular and cellular biologyLoss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007 May; 27(9):3405-16.Mol Cell Biol2007-02-26T00:00:002007Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos.17984964Latham JA, Dent SYNature structural & molecular biologyCross-regulation of histone modifications. Nat Struct Mol Biol. 2007 Nov; 14(11):1017-24.Nat Struct Mol Biol2007-11-05T00:00:002007Cross-regulation of histone modifications.18022353Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang YCellNew nomenclature for chromatin-modifying enzymes. Cell. 2007 Nov 16; 131(4):633-6.Cell2007-11-16T00:00:002007New nomenclature for chromatin-modifying enzymes.18820300Soragni E, Herman D, Dent SY, Gottesfeld JM, Wells RD, Napierala MNucleic acids researchLong intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia. Nucleic Acids Res. 2008 Nov; 36(19):6056-65.Nucleic Acids Res2008-09-27T00:00:002008Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia.19683498Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent SYMolecular cellGcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell. 2009 Aug 14; 35(3):352-64.Mol Cell2009-08-14T00:00:002009Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.21596989Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KSScience (New York, N.Y.)Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science. 2011 May 20; 332(6032):963-6.Science2011-05-20T00:00:002011Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.21628526Wilson MA, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton MC, Dent SYMolecular and cellular biologyUbp8 and SAGA regulate Snf1 AMP kinase activity. Mol Cell Biol. 2011 Aug; 31(15):3126-35.Mol Cell Biol2011-05-31T00:00:002011Ubp8 and SAGA regulate Snf1 AMP kinase activity.21884933Latham JA, Chosed RJ, Wang S, Dent SYCellChromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination. Cell. 2011 Sep 02; 146(5):709-19.Cell2011-09-02T00:00:002011Chromatin signaling to kinetochores: transregulation of Dam1 methylation by histone H2B ubiquitination.22745758Mart?nez-Cerde?o V, Lemen JM, Chan V, Wey A, Lin W, Dent SR, Knoepfler PSPloS oneN-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. PLoS One. 2012; 7(6):e39456.PLoS One2012-06-26T00:00:002012N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.23236151McCullough SD, Xu X, Dent SY, Bekiranov S, Roeder RG, Grant PAProceedings of the National Academy of Sciences of the United States of AmericaReelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21319-24.Proc Natl Acad Sci U S A2012-12-10T00:00:002012Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.25071153Jin Q, Wang C, Kuang X, Feng X, Sartorelli V, Ying H, Ge K, Dent SYMolecular and cellular biologyGcn5 and PCAF regulate PPAR? and Prdm16 expression to facilitate brown adipogenesis. Mol Cell Biol. 2014 Oct 01; 34(19):3746-53.Mol Cell Biol2014-07-28T00:00:002014Gcn5 and PCAF regulate PPAR? and Prdm16 expression to facilitate brown adipogenesis.Authorship 2649896Authorship 2650666Authorship 2663688Authorship 2681212Authorship 2689312Authorship 2692183Authorship 2701899Authorship 2703794Authorship 2711862Authorship 271240511069890Watson AD, Edmondson DG, Bone JR, Mukai Y, Yu Y, Du W, Stillman DJ, Roth SYGenes & developmentSsn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev. 2000 Nov 01; 14(21):2737-44.Genes Dev2000-11-01T00:00:002000Ssn6-Tup1 interacts with class I histone deacetylases required for repression.11751634Briggs SD, Bryk M, Strahl BD, Cheung WL, Davie JK, Dent SY, Winston F, Allis CDGenes & developmentHistone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev. 2001 Dec 15; 15(24):3286-95.Genes Dev2001-12-15T00:00:002001Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.15937931Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SYDevelopmental dynamics : an official publication of the American Association of AnatomistsGCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005 Aug; 233(4):1337-47.Dev Dyn2005-08-01T00:00:002005GCN5 and p300 share essential functions during early embryogenesis.18429148Edmondson DG, Dent SYCurrent protocols in protein scienceIdentification of protein interactions by far western analysis. Curr Protoc Protein Sci. 2001 Nov; Chapter 19:Unit 19.7.Curr Protoc Protein Sci2001-11-01T00:00:002001Identification of protein interactions by far western analysis.19667125Latham JA, Dent SYThe Journal of cell biologyThe H2BK123Rgument. J Cell Biol. 2009 Aug 10; 186(3):313-5.J Cell Biol2009-08-10T00:00:002009The H2BK123Rgument.20363118Koutelou E, Hirsch CL, Dent SYCurrent opinion in cell biologyMultiple faces of the SAGA complex. Curr Opin Cell Biol. 2010 Jun; 22(3):374-82.Curr Opin Cell Biol2010-04-02T00:00:002010Multiple faces of the SAGA complex.21131905Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge KThe EMBO journalDistinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J. 2011 Jan 19; 30(2):249-62.EMBO J2010-12-03T00:00:002010Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.22449188Butler JS, Koutelou E, Schibler AC, Dent SYEpigenomicsHistone-modifying enzymes: regulators of developmental decisions and drivers of human disease. Epigenomics. 2012 Apr; 4(2):163-77.Epigenomics2012-04-01T00:00:002012Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.23287864Butler JS, Dent SYBloodThe role of chromatin modifiers in normal and malignant hematopoiesis. Blood. 2013 Apr 18; 121(16):3076-84.Blood2013-01-02T00:00:002013The role of chromatin modifiers in normal and malignant hematopoiesis.24051374Ravnskjaer K, Hogan MF, Lackey D, Tora L, Dent SY, Olefsky J, Montminy MThe Journal of clinical investigationGlucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest. 2013 Oct; 123(10):4318-28.J Clin Invest2013-09-24T00:00:002013Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.Authorship 2740004Authorship 2751432Authorship 275634Authorship 2759352Authorship 275958Authorship 2768891915278Shimizu M, Roth SY, Szent-Gyorgyi C, Simpson RTThe EMBO journalNucleosomes are positioned with base pair precision adjacent to the alpha 2 operator in Saccharomyces cerevisiae. EMBO J. 1991 Oct; 10(10):3033-41.EMBO J1991-10-01T00:00:001991Nucleosomes are positioned with base pair precision adjacent to the alpha 2 operator in Saccharomyces cerevisiae.2183026Roth SY, Dean A, Simpson RTMolecular and cellular biologyYeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin. Mol Cell Biol. 1990 May; 10(5):2247-60.Mol Cell Biol1990-05-01T00:00:001990Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.7956034Simpson RT, Roth SY, Morse RH, Patterton HG, Cooper JP, Murphy M, Kladde MP, Shimizu MCold Spring Harbor symposia on quantitative biologyNucleosome positioning and transcription. Cold Spring Harb Symp Quant Biol. 1993; 58:237-45.Cold Spring Harb Symp Quant Biol1993-01-01T00:00:001993Nucleosome positioning and transcription.9343419Huang L, Zhang W, Roth SYMolecular and cellular biologyAmino termini of histones H3 and H4 are required for a1-alpha2 repression in yeast. Mol Cell Biol. 1997 Nov; 17(11):6555-62.Mol Cell Biol1997-11-01T00:00:001997Amino termini of histones H3 and H4 are required for a1-alpha2 repression in yeast.19927124Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe BThe EMBO journalRegulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J. 2010 Jan 06; 29(1):68-79.EMBO J2009-11-19T00:00:002009Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase.24366184Chen T, Dent SYNature reviews. GeneticsChromatin modifiers and remodellers: regulators of cellular differentiation. Nat Rev Genet. 2014 Feb; 15(2):93-106.Nat Rev Genet2013-12-24T00:00:002013Chromatin modifiers and remodellers: regulators of cellular differentiation.Authorship 2787969Authorship 279652213204116Roth SY, Schulman IG, Richman R, Cook RG, Allis CDThe Journal of cell biologyCharacterization of phosphorylation sites in histone H1 in the amitotic macronucleus of Tetrahymena during different physiological states. J Cell Biol. 1988 Dec; 107(6 Pt 2):2473-82.J Cell Biol1988-12-01T00:00:001988Characterization of phosphorylation sites in histone H1 in the amitotic macronucleus of Tetrahymena during different physiological states.3671074Roth SY, Schulman IG, Cook RG, Allis CDNucleic acids researchThe complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena. Nucleic Acids Res. 1987 Oct 12; 15(19):8112.Nucleic Acids Res1987-10-12T00:00:001987The complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena.6865943Yoder SS, Robberson BL, Leys EJ, Hook AG, Al-Ubaidi M, Yeung CY, Kellems RE, Berget SMMolecular and cellular biologyControl of cellular gene expression during adenovirus infection: induction and shut-off of dihydrofolate reductase gene expression by adenovirus type 2. Mol Cell Biol. 1983 May; 3(5):819-28.Mol Cell Biol1983-05-01T00:00:001983Control of cellular gene expression during adenovirus infection: induction and shut-off of dihydrofolate reductase gene expression by adenovirus type 2.Authorship 2906522Authorship 29140211Authorship 2938677Authorship 2940043Authorship 2946996Authorship 29890710Authorship 30566121Authorship 30907297618560Peterfy CG, van Dijke CF, Lu Y, Nguyen A, Connick TJ, Kneeland JB, Tirman PF, Lang P, Dent S, Genant HKAJR. American journal of roentgenologyQuantification of the volume of articular cartilage in the metacarpophalangeal joints of the hand: accuracy and precision of three-dimensional MR imaging. AJR Am J Roentgenol. 1995 Aug; 165(2):371-5.AJR Am J Roentgenol1995-08-01T00:00:001995Quantification of the volume of articular cartilage in the metacarpophalangeal joints of the hand: accuracy and precision of three-dimensional MR imaging.25111486Wang L, Dent SYEpigenomicsFunctions of SAGA in development and disease. Epigenomics. 2014 Jun; 6(3):329-39.Epigenomics2014-06-01T00:00:002014Functions of SAGA in development and disease.25269644Jin Q, Zhuang L, Lai B, Wang C, Li W, Dolan B, Lu Y, Wang Z, Zhao K, Peng W, Dent SY, Ge KEMBO reportsGcn5 and PCAF negatively regulate interferon-? production through HAT-independent inhibition of TBK1. EMBO Rep. 2014 Nov; 15(11):1192-201.EMBO Rep2014-09-30T00:00:002014Gcn5 and PCAF negatively regulate interferon-? production through HAT-independent inhibition of TBK1.25567983Tomida J, Takata K, Lange SS, Schibler AC, Yousefzadeh MJ, Bhetawal S, Dent SY, Wood RDNucleic acids researchREV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ?. Nucleic Acids Res. 2015 Jan; 43(2):1000-11.Nucleic Acids Res2015-01-07T00:00:002015REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ?.25659580Farria A, Li W, Dent SYOncogeneKATs in cancer: functions and therapies. Oncogene. 2015 Sep 17; 34(38):4901-13.Oncogene2015-02-09T00:00:002015KATs in cancer: functions and therapies.25755283Lan X, Koutelou E, Schibler AC, Chen YC, Grant PA, Dent SYMolecular and cellular biologyPoly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module. Mol Cell Biol. 2015 May; 35(10):1777-87.Mol Cell Biol2015-03-09T00:00:002015Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating Module.26109054Hirsch CL, Akdemir ZC, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SYGenes & developmentCorrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev. 2015 Jun 15; 29(12):1341.Genes Dev2015-06-15T00:00:002015Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.26288350Perez CJ, Mecklenburg L, Jaubert J, Martinez-Santamaria L, Iritani BM, Espejo A, Napoli E, Song G, Del R?o M, DiGiovanni J, Giulivi C, Bedford MT, Dent SYR, Wood RD, Kusewitt DF, Gu?net JL, Conti CJ, Benavides FThe Journal of investigative dermatologyIncreased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. J Invest Dermatol. 2015 Dec; 135(12):3133-3143.J Invest Dermatol2015-08-19T00:00:002015Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene.8805705Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CDNatureTranscription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature. 1996 Sep 19; 383(6597):269-72.Nature1996-09-19T00:00:001996Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines.74Professor10Assistant Professor54Instructor14Associate Professor47Distinguished Service Professor27132940Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SYMolecular cellATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth. Mol Cell. 2016 05 19; 62(4):558-71.Mol Cell2016-04-28T00:00:002016ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.23193179Chen K, Xi Y, Pan X, Li Z, Kaestner K, Tyler J, Dent S, He X, Li WGenome researchDANPOS: dynamic analysis of nucleosome position and occupancy by sequencing. Genome Res. 2013 Feb; 23(2):341-51.Genome Res2012-11-28T00:00:002012DANPOS: dynamic analysis of nucleosome position and occupancy by sequencing.20080737Lin Y, Dent SY, Wilson JH, Wells RD, Napierala MProceedings of the National Academy of Sciences of the United States of AmericaR loops stimulate genetic instability of CTG.CAG repeats. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):692-7.Proc Natl Acad Sci U S A2009-12-22T00:00:002009R loops stimulate genetic instability of CTG.CAG repeats.22002997Chen YC, Gatchel JR, Lewis RW, Mao CA, Grant PA, Zoghbi HY, Dent SYHuman molecular geneticsGcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model. Hum Mol Genet. 2012 Jan 15; 21(2):394-405.Hum Mol Genet2011-10-14T00:00:002011Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Authorship 841229Authorship 842353Authorship 844539Authorship 844559Authorship 844599Authorship 844859Authorship 845302Authorship 845776Authorship 849090Authorship 853123Authorship 865770Cell ReportsUSP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B. Cell Reports. 17:2382-2393.USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2BGenes and DevelopmentHistone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes and Development. 30:1187-1197.Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2Journal of Visualized ExperimentsSelecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts. Journal of Visualized Experiments. Selecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblastsLeukemia and LymphomaLow expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia. Leukemia and Lymphoma. 1-12.Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemiaChemtractsEssential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of Gcn5p acetyltransferase. Chemtracts. 12:748-754.Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of Gcn5p acetyltransferaseMolecular CellATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth. Molecular Cell. ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor GrowthMolecular TherapyExcision of expanded GAA repeats alleviates the molecular phenotype of friedreich's ataxia. Molecular Therapy. 23:1055-1065.Excision of expanded GAA repeats alleviates the molecular phenotype of friedreich's ataxiaOncogeneTRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene. TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formationMolecular and Cellular BiologyCytoplasmic ATXN7L3B interferes with nuclear functions of the SAGA deubiquitinase module. Molecular and Cellular Biology. 36:2855-2866.Cytoplasmic ATXN7L3B interferes with nuclear functions of the SAGA deubiquitinase moduleJournal of Molecular BiologyKATapulting toward Pluripotency and Cancer. Journal of Molecular Biology. KATapulting toward Pluripotency and CancerHistone Acetyltransferases in Development. 105-113.Histone Acetyltransferases in Development2983122Yoder SS, Berget SMJournal of virologyPosttranscriptional control of DHFR gene expression during adenovirus 2 infection. J Virol. 1985 Apr; 54(1):72-7.J Virol1985-04-01T00:00:001985Posttranscriptional control of DHFR gene expression during adenovirus 2 infection.3773056Yoder SS, Berget SMJournal of virologyRole of adenovirus type 2 early region 4 in the early-to-late switch during productive infection. J Virol. 1986 Nov; 60(2):779-81.J Virol1986-11-01T00:00:001986Role of adenovirus type 2 early region 4 in the early-to-late switch during productive infection.28068325Li J, Xi Y, Li W, McCarthy RL, Stratton SA, Zou W, Li W, Dent SY, Jain AK, Barton MCOncogeneTRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene. 2017 05 25; 36(21):2991-3001.Oncogene2017-01-09T00:00:002017TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.14654786Coombes MM, Briggs KL, Bone JR, Clayman GL, El-Naggar AK, Dent SYOncogeneResetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. Oncogene. 2003 Dec 04; 22(55):8902-11.Oncogene2003-12-04T00:00:002003Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation.23124522Chen K, Wilson MA, Hirsch C, Watson A, Liang S, Lu Y, Li W, Dent SYGenome researchStabilization of the promoter nucleosomes in nucleosome-free regions by the yeast Cyc8-Tup1 corepressor. Genome Res. 2013 Feb; 23(2):312-22.Genome Res2012-11-02T00:00:002012Stabilization of the promoter nucleosomes in nucleosome-free regions by the yeast Cyc8-Tup1 corepressor.29057918Mi W, Guan H, Lyu J, Zhao D, Xi Y, Jiang S, Andrews FH, Wang X, Gagea M, Wen H, Tora L, Dent SYR, Kutateladze TG, Li W, Li H, Shi XNature communicationsYEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun. 2017 10 20; 8(1):1088.Nat Commun2017-10-20T00:00:002017YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.29458327Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Kraus WL, Li W, Dent SYRBMC genomicsHistone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics. 2018 02 20; 19(1):150.BMC Genomics2018-02-20T00:00:002018Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes.Authorship 88777920Authorship 88850211Authorship 8895688Authorship 88998520D051548Chemicals & Drugs1344100.835917Histone AcetyltransferasesD029701Chemicals & Drugs1514430.757974Saccharomyces cerevisiae ProteinsD050880Chemicals & Drugs631090.923328p300-CBP Transcription FactorsD002843AnatomyChemicals & DrugsPhysiology4189420.658063ChromatinD006657Chemicals & Drugs56614670.573909HistonesAuthorship 9064731Authorship 90735013Authorship 90794610Authorship 9130933Authorship 91346310Authorship 9153964Authorship 92034516Authorship 92108210Authorship 9216305Authorship 9231286Authorship 92737711Authorship 92871416Authorship 93733915Authorship 940114226728851Dent S, Sedwick CThe Journal of cell biologySharon Dent: The unfolding SAGA of chromatin-modifying proteins. J Cell Biol. 2016 Jan 04; 212(1):4-5.J Cell Biol2016-01-04T00:00:002016Sharon Dent: The unfolding SAGA of chromatin-modifying proteins.27198228Schibler A, Koutelou E, Tomida J, Wilson-Pham M, Wang L, Lu Y, Cabrera AP, Chosed RJ, Li W, Li B, Shi X, Wood RD, Dent SYGenes & developmentHistone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes Dev. 2016 05 15; 30(10):1187-97.Genes Dev2016-05-15T00:00:002016Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2.27880911Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SYRCell reportsUSP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B. Cell Rep. 2016 11 22; 17(9):2382-2393.Cell Rep2016-11-22T00:00:002016USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.28154153Wilde JJ, Siegenthaler JA, Dent SY, Niswander LAThe Journal of neuroscience : the official journal of the Society for NeuroscienceDiencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling. J Neurosci. 2017 03 08; 37(10):2565-2579.J Neurosci2017-02-02T00:00:002017Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling.28185526Butler JS, Qiu YH, Zhang N, Yoo SY, Coombes KR, Dent SY, Kornblau SMLeukemia & lymphomaLow expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia. Leuk Lymphoma. 2017 05; 58(5):1207-1218.Leuk Lymphoma2016-10-13T00:00:002016Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia.27601583Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SYRMolecular and cellular biologyCytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. Mol Cell Biol. 2016 11 15; 36(22):2855-2866.Mol Cell Biol2016-10-28T00:00:002016Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module.28424240Gao B, Kong Q, Zhang Y, Yun C, Dent SYR, Song J, Zhang DD, Wang Y, Li X, Fang DJournal of immunology (Baltimore, Md. : 1950)The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol. 2017 05 15; 198(10):3927-3938.J Immunol2017-04-19T00:00:002017The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.28723564Wang Y, Yun C, Gao B, Xu Y, Zhang Y, Wang Y, Kong Q, Zhao F, Wang CR, Dent SYR, Wang J, Xu X, Li HB, Fang DCell reportsThe Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep. 2017 07 18; 20(3):600-612.Cell Rep2017-07-18T00:00:002017The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.29249668Wang L, Koutelou E, Hirsch C, McCarthy R, Schibler A, Lin K, Lu Y, Jeter C, Shen J, Barton MC, Dent SYRStem cell reportsGCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation. Stem Cell Reports. 2018 01 09; 10(1):287-299.Stem Cell Reports2017-12-14T00:00:002017GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation.29523690Appikonda S, Thakkar KN, Shah PK, Dent SYR, Andersen JN, Barton MCThe Journal of biological chemistryCross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion. J Biol Chem. 2018 05 11; 293(19):7476-7485.J Biol Chem2018-03-09T00:00:002018Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion.29273624Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WLGenome researchEnhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome Res. 2018 02; 28(2):159-170.Genome Res2017-12-22T00:00:002017Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.30135305Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gait?n-Pe?as H, Gu?net JL, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Est?vez R, Pan HL, Geha RS, Shi Q, Benavides FJCI insightDeficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight. 2018 08 23; 3(16).JCI Insight2018-08-23T00:00:002018Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.30341066Lambies G, Miceli M, Mart?nez-Guillamon C, Olivera-Salguero R, Pe?a R, Fr?as CP, Calder?n I, Atanassov BS, Dent SYR, Arribas J, Garc?a de Herreros A, D?az VMCancer researchTGF?-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1. Cancer Res. 2019 01 01; 79(1):33-46.Cancer Res2018-10-19T00:00:002018TGF?-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1.30718289Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y, Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang DG, Dent SYRDevelopment (Cambridge, England)USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. Development. 2019 02 22; 146(4).Development2019-02-22T00:00:002019USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.Department of Molecular & Cellular BiologyMolecular & Cellular BiologyBaylor College of MedicineBERTO'MALLEYBERT O'MALLEY0.000000000000000.000000000000002464O'MALLEY, BERTDistinguished Service ProfessorAuthorship 945457831003455Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WWCancersComplementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers (Basel). 2019 Apr 18; 11(4).Cancers (Basel)2019-04-18T00:00:002019Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.Authorship 955166531497362Mustachio LM, Roszik J, Farria AT, Guerra K, Dent SYAmerican journal of cancer researchRepression of GCN5 expression or activity attenuates c-MYC expression in non-small cell lung cancer. Am J Cancer Res. 2019; 9(8):1830-1845.Am J Cancer Res2019-08-01T00:00:002019Repression of GCN5 expression or activity attenuates c-MYC expression in non-small cell lung cancer.Authorship 957774431645904Farria AT, Mustachio LM, Akdemir ZHC, Dent SYROncotargetGCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways. Oncotarget. 2019 Oct 08; 10(56):5847-5858.Oncotarget2019-10-08T00:00:002019GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways.true1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 978471432094302Mustachio LM, Roszik J, Farria A, Dent SYRCancer researchTargeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers. Cancer Res. 2020 05 15; 80(10):1905-1911.Cancer Res2020-02-24T00:00:002020Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers.Authorship 995725332730897Koutelou E, Farria AT, Dent SYRBiochimica et biophysica acta. Gene regulatory mechanismsComplex functions of Gcn5 and Pcaf in development and disease. Biochim Biophys Acta Gene Regul Mech. 2021 02; 1864(2):194609.Biochim Biophys Acta Gene Regul Mech2020-07-28T00:00:002020Complex functions of Gcn5 and Pcaf in development and disease.Authorship 1004756933168647Farria AT, Plummer JB, Salinger AP, Shen J, Lin K, Lu Y, McBride KM, Koutelou E, Dent SYRCancer researchTranscriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis. Cancer Res. 2020 12 15; 80(24):5543-5553.Cancer Res2020-11-09T00:00:002020Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis.Authorship 1020803234112237Chen YC, Dent SYREpigenetics & chromatinConservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms. Epigenetics Chromatin. 2021 06 10; 14(1):26.Epigenetics Chromatin2021-06-10T00:00:002021Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms.Authorship 10293371134503086Kuang X, McAndrew MJ, Mustachio LM, Chen YC, Atanassov BS, Lin K, Lu Y, Shen J, Salinger A, Macatee T, Dent SYR, Koutelou ECancersUsp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice. Cancers (Basel). 2021 Aug 25; 13(17).Cancers (Basel)2021-08-25T00:00:002021Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.Authorship 1032000634657330Perez CJ, Mecklenburg L, Fernandez A, Cantero M, de Souza TA, Lin K, Dent SYR, Montoliu L, Awgulewitsch A, Benavides FExperimental dermatologyNaked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13. Exp Dermatol. 2022 03; 31(3):330-340.Exp Dermatol2021-10-25T00:00:002021Naked (N) mutant mice carry a nonsense mutation in the homeobox of Hoxc13.Authorship 1037193335016034Chen YC, Koutelou E, Dent SYRMolecular cellNow open: Evolving insights to the roles of lysine acetylation in chromatin organization and function. Mol Cell. 2022 02 17; 82(4):716-727.Mol Cell2022-01-10T00:00:002022Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function.Authorship 1043735235411082Koutelou E, Dent SYRNature cell biologyNavigating EMT with COMPASS and PRC2. Nat Cell Biol. 2022 Apr; 24(4):412-414.Nat Cell Biol2022-04-01T00:00:002022Navigating EMT with COMPASS and PRC2.Authorship 1087064538236941Kuang X, Salinger A, Benavides F, Muller WJ, Dent SYR, Koutelou EPloS oneUSP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity. PLoS One. 2024; 19(1):e0290837.PLoS One2024-01-18T00:00:002024USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity.true1ProfessorProfessortrue1InstructorInstructortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessor