XINLINXIN LIN9210LIN, XINProfessorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson1515 Holcombe BlvdHouston77030-4009TXAuthorship 1651613Authorship 1662062Authorship 1668531Authorship 1683741Authorship 1692762Authorship 1756151Authorship 1770345Authorship 1775841Authorship 1782667Authorship 1859059Authorship 18675110Authorship 1906052Authorship 1908142Authorship 1921818Authorship 192779117613465Howarth JW, Krudy GA, Lin X, Putkey JA, Rosevear PRProtein science : a publication of the Protein SocietyAn NMR and spin label study of the effects of binding calcium and troponin I inhibitory peptide to cardiac troponin C. Protein Sci. 1995 Apr; 4(4):671-80.Protein Sci1995-04-01T00:00:001995An NMR and spin label study of the effects of binding calcium and troponin I inhibitory peptide to cardiac troponin C.9119404L?decke HJ, Ahn J, Lin X, Hill A, Wagner MJ, Schomburg L, Horsthemke B, Wells DEGenomicsGenomic organization and promoter structure of the human EXT1 gene. Genomics. 1997 Mar 01; 40(2):351-4.Genomics1997-03-01T00:00:001997Genomic organization and promoter structure of the human EXT1 gene.9441765Lin X, Wells DEGenomicsLocalization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters. Genomics. 1997 Dec 15; 46(3):526-8.Genomics1997-12-15T00:00:001997Localization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters.11027214Foehr ED, Lin X, O'Mahony A, Geleziunas R, Bradshaw RA, Greene WCThe Journal of neuroscience : the official journal of the Society for NeuroscienceNF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells. J Neurosci. 2000 Oct 15; 20(20):7556-63.J Neurosci2000-10-15T00:00:002000NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells.15459204Liu XK, Lin X, Gaffen SLThe Journal of biological chemistryCrucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17. J Biol Chem. 2004 Dec 10; 279(50):52762-71.J Biol Chem2004-09-30T00:00:002004Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17.17502353Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, Lin X, Wen RMolecular and cellular biologyPhosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol. 2007 Jul; 27(14):5235-45.Mol Cell Biol2007-05-14T00:00:002007Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation.17549681Lin X, Wood CG, Shao L, Huang M, Yang H, Dinney CP, Wu XCancerRisk assessment of renal cell carcinoma using alkaline comet assay. Cancer. 2007 Jul 15; 110(2):282-8.Cancer2007-07-15T00:00:002007Risk assessment of renal cell carcinoma using alkaline comet assay.20493730Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong CImmunityThe E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28; 32(5):670-80.Immunity2010-05-20T00:00:002010The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.22435552Jiang C, Lin XImmunological reviewsRegulation of NF-?B by the CARD proteins. Immunol Rev. 2012 Mar; 246(1):141-53.Immunol Rev2012-03-01T00:00:002012Regulation of NF-?B by the CARD proteins.23911656Zhu LL, Zhao XQ, Jiang C, You Y, Chen XP, Jiang YY, Jia XM, Lin XImmunityC-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity. 2013 Aug 22; 39(2):324-34.Immunity2013-08-01T00:00:002013C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.23990113Zhang L, Pham LV, Newberry KJ, Ou Z, Liang R, Qian J, Sun L, Blonska M, You Y, Yang J, Lin X, Rollo A, Tamayo AT, Lee J, Ford RJ, Zhao X, Kwak LW, Yi Q, Wang MMolecular cancer therapeuticsIn vitro and in vivo therapeutic efficacy of carfilzomib in mantle cell lymphoma: targeting the immunoproteasome. Mol Cancer Ther. 2013 Nov; 12(11):2494-504.Mol Cancer Ther2013-08-29T00:00:002013In vitro and in vivo therapeutic efficacy of carfilzomib in mantle cell lymphoma: targeting the immunoproteasome.EpidemiologyInfectious Diseases, Infection Control, and Employee HealthLymphoma-MyelomaMolecular & Cellular OncologySystems BiologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorPAUL JCHIAOPAUL J CHIAO8585CHIAO, PAUL JProfessorXIFENGWUXIFENG WU8625WU, XIFENGProfessorDIMITRIOS PKONTOYIANNISDIMITRIOS P KONTOYIANNIS8761KONTOYIANNIS, DIMITRIOS PProfessorCHANGYINGJIANGCHANGYING JIANG9493JIANG, CHANGYINGAssistant ProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessorJIANGUJIAN GU8808GU, JIANAssociate Professor3.375020.00469106473research areas0.8641530.01850722coauthor of65.12638.8780260similar to1189selected publicationsCOLIN PDINNEYCOLIN P DINNEY8624DINNEY, COLIN PProfessorSHAO-CONGSUNSHAO-CONG SUN9405SUN, SHAO-CONGProfessorAuthorship 2146553Authorship 2172001Authorship 2175932Authorship 2182166Authorship 2193491Authorship 2200258Authorship 2210997Authorship 2220855Authorship 2235982Authorship 2237049Authorship 22387510Authorship 2239604Authorship 2244109Authorship 2254705Authorship 2260073Authorship 23255410Authorship 23290911Authorship 2330582Authorship 2346526Authorship 23469268033994Liu W, Dotson DG, Lin X, Mullen JJ, Gonzalez-Garay ML, Lu Q, Putkey JAFEBS lettersThe presence but not the sequence of the N-terminal peptide in cardiac TnC is important for function. FEBS Lett. 1994 Jun 27; 347(2-3):152-6.FEBS Lett1994-06-27T00:00:001994The presence but not the sequence of the N-terminal peptide in cardiac TnC is important for function.9261139Ghoda L, Lin X, Greene WCThe Journal of biological chemistryThe 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem. 1997 Aug 22; 272(34):21281-8.J Biol Chem1997-08-22T00:00:001997The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro.9703997Lin X, Gan L, Klein WH, Wells DBiochemical and biophysical research communicationsExpression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):738-43.Biochem Biophys Res Commun1998-07-30T00:00:001998Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene.10980190Foehr ED, Bohuslav J, Chen LF, DeNoronha C, Geleziunas R, Lin X, O'Mahony A, Greene WCThe Journal of biological chemistryThe NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis. J Biol Chem. 2000 Nov 03; 275(44):34021-4.J Biol Chem2000-11-03T00:00:002000The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis.12154356Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nu?ez G, Bertin J, Lin XNature immunologyA requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol. 2002 Sep; 3(9):830-5.Nat Immunol2002-08-05T00:00:002002A requirement for CARMA1 in TCR-induced NF-kappa B activation.12857891Lin X, Irwin D, Kanazawa S, Huang L, Romeo J, Yen TS, Peterlin BMJournal of virologyTranscriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir. J Virol. 2003 Aug; 77(15):8227-36.J Virol2003-08-01T00:00:002003Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir.14673152Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin XMolecular and cellular biologyCD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol. 2004 Jan; 24(1):164-71.Mol Cell Biol2004-01-01T00:00:002004CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1.16543241Li H, Kobayashi M, Blonska M, You Y, Lin XThe Journal of biological chemistryUbiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem. 2006 May 12; 281(19):13636-13643.J Biol Chem2006-03-16T00:00:002006Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation.17127293Wu X, Lin X, Dinney CP, Gu J, Grossman HBFrontiers in bioscience : a journal and virtual libraryGenetic polymorphism in bladder cancer. Front Biosci. 2007 Jan 01; 12:192-213.Front Biosci2007-01-01T00:00:002007Genetic polymorphism in bladder cancer.17187069Hsu YM, Zhang Y, You Y, Wang D, Li H, Duramad O, Qin XF, Dong C, Lin XNature immunologyThe adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb; 8(2):198-205.Nat Immunol2006-12-24T00:00:002006The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens.17287217Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto CThe Journal of biological chemistryCaveolin-1 triggers T-cell activation via CD26 in association with CARMA1. J Biol Chem. 2007 Mar 30; 282(13):10117-10131.J Biol Chem2007-02-06T00:00:002007Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.17363905Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, Darnay BG, Hara H, Penninger J, Lin XThe EMBO journalPhosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 2007 Apr 04; 26(7):1794-805.EMBO J2007-03-15T00:00:002007Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.17428801Tanner MJ, Hanel W, Gaffen SL, Lin XThe Journal of biological chemistryCARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation. J Biol Chem. 2007 Jun 08; 282(23):17141-7.J Biol Chem2007-04-11T00:00:002007CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation.17543278Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao ACBiochemical and biophysical research communicationsLIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway. Biochem Biophys Res Commun. 2007 Jul 27; 359(2):379-84.Biochem Biophys Res Commun2007-05-25T00:00:002007LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.18381966Yang H, Gu J, Lin X, Grossman HB, Ye Y, Dinney CP, Wu XClinical cancer research : an official journal of the American Association for Cancer ResearchProfiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. Clin Cancer Res. 2008 Apr 01; 14(7):2236-44.Clin Cancer Res2008-04-01T00:00:002008Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition.22749346Blonska M, Lin XImmunityDampening NF-?B signaling by "self-eating". Immunity. 2012 Jun 29; 36(6):895-6.Immunity2012-06-29T00:00:002012Dampening NF-?B signaling by "self-eating".23200858Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TMCell reportsTracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep. 2012 Dec 27; 2(6):1762-73.Cell Rep2012-11-29T00:00:002012Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung.23630357Shenderov K, Barber DL, Mayer-Barber KD, Gurcha SS, Jankovic D, Feng CG, Oland S, Hieny S, Caspar P, Yamasaki S, Lin X, Ting JP, Trinchieri G, Besra GS, Cerundolo V, Sher AJournal of immunology (Baltimore, Md. : 1950)Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. J Immunol. 2013 Jun 01; 190(11):5722-30.J Immunol2013-04-29T00:00:002013Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.24391211Wang H, LeBert V, Hung CY, Galles K, Saijo S, Lin X, Cole GT, Klein BS, W?thrich MJournal of immunology (Baltimore, Md. : 1950)C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol. 2014 Feb 01; 192(3):1107-1119.J Immunol2014-01-03T00:00:002014C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America.24634491Cheng Q, Zhang Q, Xu X, Yin L, Sun L, Lin X, Dong C, Pan WJournal of immunology (Baltimore, Md. : 1950)MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice. J Immunol. 2014 Apr 15; 192(8):3686-96.J Immunol2014-03-14T00:00:002014MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice.Authorship 2389632Authorship 2398903Authorship 2405421Authorship 2405473Authorship 2414551Authorship 2423012Authorship 2430111Authorship 2439192Authorship 2457961Authorship 2483587Authorship 2485394Authorship 2488388Authorship 2490423Authorship 2499194Authorship 2506819Authorship 2520082Authorship 2521614Authorship 2524506Authorship 2539719Authorship 2567607Authorship 2583756Authorship 26239718550567Lin X, Dotson DG, Putkey JAThe Journal of biological chemistryCovalent binding of peptides to the N-terminal hydrophobic region of cardiac troponin C has limited effects on function. J Biol Chem. 1996 Jan 05; 271(1):244-9.J Biol Chem1996-01-05T00:00:001996Covalent binding of peptides to the N-terminal hydrophobic region of cardiac troponin C has limited effects on function.8661098Gu JZ, Lin X, Wells DEGenomicsThe human B22 subunit of the NADH-ubiquinone oxidoreductase maps to the region of chromosome 8 involved in branchio-oto-renal syndrome. Genomics. 1996 Jul 01; 35(1):6-10.Genomics1996-07-01T00:00:001996The human B22 subunit of the NADH-ubiquinone oxidoreductase maps to the region of chromosome 8 involved in branchio-oto-renal syndrome.9020797Putkey JA, Liu W, Lin X, Ahmed S, Zhang M, Potter JD, Kerrick WGBiochemistryFluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ. Biochemistry. 1997 Jan 28; 36(4):970-8.Biochemistry1997-01-28T00:00:001997Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ.9710600Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WCMolecular and cellular biologyHuman T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. Mol Cell Biol. 1998 Sep; 18(9):5157-65.Mol Cell Biol1998-09-01T00:00:001998Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.9742107Lin X, Mu Y, Cunningham ET, Marcu KB, Geleziunas R, Greene WCMolecular and cellular biologyMolecular determinants of NF-kappaB-inducing kinase action. Mol Cell Biol. 1998 Oct; 18(10):5899-907.Mol Cell Biol1998-10-01T00:00:001998Molecular determinants of NF-kappaB-inducing kinase action.10077726Lin X, Wells DE, Kimberling WJ, Kumar SHuman heredityHuman NDUFB9 gene: genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13. Hum Hered. 1999 Mar; 49(2):75-80.Hum Hered1999-03-01T00:00:001999Human NDUFB9 gene: genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13.10648602O'Mahony A, Lin X, Geleziunas R, Greene WCMolecular and cellular biologyActivation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol Cell Biol. 2000 Feb; 20(4):1170-8.Mol Cell Biol2000-02-01T00:00:002000Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions.11739744Taube R, Lin X, Irwin D, Fujinaga K, Peterlin BMMolecular and cellular biologyInteraction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol Cell Biol. 2002 Jan; 22(1):321-31.Mol Cell Biol2002-01-01T00:00:002002Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes.11884399Lin X, Taube R, Fujinaga K, Peterlin BMThe Journal of biological chemistryP-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. J Biol Chem. 2002 May 10; 277(19):16873-8.J Biol Chem2002-03-07T00:00:002002P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.15541657Lin X, Wang DSeminars in immunologyThe roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol. 2004 Dec; 16(6):429-35.Semin Immunol2004-12-01T00:00:002004The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling.16260783Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B, Lin XThe Journal of biological chemistryTAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem. 2005 Dec 30; 280(52):43056-63.J Biol Chem2005-10-31T00:00:002005TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.16651533Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao ACProceedings of the National Academy of Sciences of the United States of AmericaStat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7264-9.Proc Natl Acad Sci U S A2006-05-01T00:00:002006Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation.16785236Sethi G, Ahn KS, Sandur SK, Lin X, Chaturvedi MM, Aggarwal BBThe Journal of biological chemistryIndirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006 Aug 18; 281(33):23425-35.J Biol Chem2006-06-19T00:00:002006Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.17179215Wang D, You Y, Lin PC, Xue L, Morris SW, Zeng H, Wen R, Lin XProceedings of the National Academy of Sciences of the United States of AmericaBcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):145-50.Proc Natl Acad Sci U S A2006-12-19T00:00:002006Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors.17220334Huang M, Dinney CP, Lin X, Lin J, Grossman HB, Wu XCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyHigh-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 2007 Jan; 16(1):84-91.Cancer Epidemiol Biomarkers Prev2007-01-01T00:00:002007High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.17438001Grabiner BC, Blonska M, Lin PC, You Y, Wang D, Sun J, Darnay BG, Dong C, Lin XGenes & developmentCARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev. 2007 Apr 15; 21(8):984-96.Genes Dev2007-04-15T00:00:002007CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation.18781579Nadiminty N, Chun JY, Lou W, Lin X, Gao ACThe ProstateNF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Prostate. 2008 Dec 01; 68(16):1725-33.Prostate2008-12-01T00:00:002008NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation.18952848Sun J, Lin XProceedings of the National Academy of Sciences of the United States of AmericaBeta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17085-90.Proc Natl Acad Sci U S A2008-10-24T00:00:002008Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation.19124758Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DMJournal of immunology (Baltimore, Md. : 1950)Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol. 2009 Jan 15; 182(2):1146-54.J Immunol2009-01-15T00:00:002009Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.19713527Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HKScience (New York, N.Y.)The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 2009 Aug 28; 325(5944):1134-8.Science2009-08-28T00:00:002009The E3 ligase TRAF6 regulates Akt ubiquitination and activation.22041900Gorjestani S, Yu M, Tang B, Zhang D, Wang D, Lin XThe Journal of biological chemistryPhospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J Biol Chem. 2011 Dec 23; 286(51):43651-43659.J Biol Chem2011-10-31T00:00:002011Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses.22249250Wang J, Ray PS, Sim MS, Zhou XZ, Lu KP, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui XOncogeneFOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-?B signaling. Oncogene. 2012 Nov 08; 31(45):4798-802.Oncogene2012-01-16T00:00:002012FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-?B signaling.Authorship 2639141Authorship 2640651Authorship 2643061Authorship 2643473Authorship 2651981Authorship 2658504Authorship 2658684Authorship 2665216Authorship 2678026Authorship 26875427981203Lin X, Krudy GA, Howarth J, Brito RM, Rosevear PR, Putkey JABiochemistryAssignment and calcium dependence of methionyl epsilon C and epsilon H resonances in cardiac troponin C. Biochemistry. 1994 Dec 06; 33(48):14434-42.Biochemistry1994-12-06T00:00:001994Assignment and calcium dependence of methionyl epsilon C and epsilon H resonances in cardiac troponin C.9150727Wells DE, Hill A, Lin X, Ahn J, Brown N, Wagner MJHuman geneticsIdentification of novel mutations in the human EXT1 tumor suppressor gene. Hum Genet. 1997 May; 99(5):612-5.Hum Genet1997-05-01T00:00:001997Identification of novel mutations in the human EXT1 tumor suppressor gene.9254013Lin X, Wells DDNA sequence : the journal of DNA sequencing and mappingIsolation of the mouse cDNA homologous to the human EXT1 gene responsible for Hereditary Multiple Exostoses. DNA Seq. 1997; 7(3-4):199-202.DNA Seq1997-01-01T00:00:001997Isolation of the mouse cDNA homologous to the human EXT1 gene responsible for Hereditary Multiple Exostoses.10072079Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WCImmunityThe proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. Immunity. 1999 Feb; 10(2):271-80.Immunity1999-02-01T00:00:001999The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.10733597Lin X, O'Mahony A, Mu Y, Geleziunas R, Greene WCMolecular and cellular biologyProtein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta. Mol Cell Biol. 2000 Apr; 20(8):2933-40.Mol Cell Biol2000-04-01T00:00:002000Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta.14754896Che T, You Y, Wang D, Tanner MJ, Dixit VM, Lin XThe Journal of biological chemistryMALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation. J Biol Chem. 2004 Apr 16; 279(16):15870-6.J Biol Chem2004-01-30T00:00:002004MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation.15572679Blonska M, You Y, Geleziunas R, Lin XMolecular and cellular biologyRestoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells. Mol Cell Biol. 2004 Dec; 24(24):10757-65.Mol Cell Biol2004-12-01T00:00:002004Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells.15678501Lee SO, Lou W, Nadiminty N, Lin X, Gao ACThe ProstateRequirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells. Prostate. 2005 Jul 01; 64(2):160-7.Prostate2005-07-01T00:00:002005Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells.17182539Chen Y, Pappu BP, Zeng H, Xue L, Morris SW, Lin X, Wen R, Wang DJournal of immunology (Baltimore, Md. : 1950)B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells. J Immunol. 2007 Jan 01; 178(1):49-57.J Immunol2007-01-01T00:00:002007B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells.19290929Blonska M, Lin XImmunological reviewsCARMA1-mediated NF-kappaB and JNK activation in lymphocytes. Immunol Rev. 2009 Mar; 228(1):199-211.Immunol Rev2009-03-01T00:00:002009CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.Authorship 2731339Authorship 2731715Authorship 2735412Authorship 274373916356856Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin XImmunityPhosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity. 2005 Dec; 23(6):575-85.Immunity2005-12-01T00:00:002005Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation.16691626Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind JS, Berman DMCancerA nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. Cancer. 2006 Jun 15; 106(12):2716-24.Cancer2006-06-15T00:00:002006A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.18068998Li H, Lin XCytokinePositive and negative signaling components involved in TNFalpha-induced NF-kappaB activation. Cytokine. 2008 Jan; 41(1):1-8.Cytokine2008-01-01T00:00:002008Positive and negative signaling components involved in TNFalpha-induced NF-kappaB activation.22423967Yang CS, Rodgers M, Min CK, Lee JS, Kingeter L, Lee JY, Jong A, Kramnik I, Lin X, Jung JUCell host & microbeThe autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe. 2012 Mar 15; 11(3):277-89.Cell Host Microbe2012-03-15T00:00:002012The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity.Authorship 2921201110926768Lin X, Wei G, Shi Z, Dryer L, Esko JD, Wells DE, Matzuk MMDevelopmental biologyDisruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol. 2000 Aug 15; 224(2):299-311.Dev Biol2000-08-15T00:00:002000Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.25267792Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu YM, Yang L, Guan JH, Xu GT, Lin XThe Journal of experimental medicineCARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med. 2014 Oct 20; 211(11):2307-21.J Exp Med2014-09-29T00:00:002014CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.25533033Blonska M, Zhu Y, Chuang HH, You MJ, Kunkalla K, Vega F, Lin XBloodJun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment. Blood. 2015 Feb 05; 125(6):981-91.Blood2014-12-22T00:00:002014Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment.74Professor10Assistant Professor21Chair14Associate Professor16953224Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BBOncogeneEvidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007 Mar 01; 26(10):1385-97.Oncogene2006-09-04T00:00:002006Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma.Authorship 3746477Authorship 846016Authorship 846782Authorship 847139Authorship 852754Authorship 852922Authorship 853578Authorship 855309Authorship 855383Authorship 856035Authorship 856473Authorship 856687Authorship 861019Authorship 861217Authorship 865146Authorship 865738PLoS PathogensDectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathogens. 12.Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the GutNature CommunicationsNature Communications. 6.Nature CommunicationsPLoS PathogensCARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathogens. 11.CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous SystemJournal of ImmunologyPhosphoinositide 3-kinase d regulates dectin-2 signaling and the generation of Th2 and Th17 immunity. Journal of Immunology. 197:278-287.Phosphoinositide 3-kinase d regulates dectin-2 signaling and the generation of Th2 and Th17 immunityJournal of Leukocyte BiologyPKC-δ activation in neutrophils promotes fungal clearance. Journal of Leukocyte Biology. 100:581-588.PKC-δ activation in neutrophils promotes fungal clearanceMolecular and Cellular BiologyRegulation of linear ubiquitin chain assembly complex by caspase-mediated cleavage of RNF31. Molecular and Cellular Biology. 36:3010-3018.Regulation of linear ubiquitin chain assembly complex by caspase-mediated cleavage of RNF31Journal of Experimental MedicineE3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. Journal of Experimental Medicine. 213:1555-1570.E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunityCellular and Molecular ImmunologyIL-17C is required for lethal inflammation during systemic fungal infection. Cellular and Molecular Immunology. 13:474-483.IL-17C is required for lethal inflammation during systemic fungal infectionJournal of ImmunologyMincle activation and the Syk/Card9 signaling axis are central to the development of autoimmune disease of the eye. Journal of Immunology. 196:3148-3158.Mincle activation and the Syk/Card9 signaling axis are central to the development of autoimmune disease of the eyeCell ReportsCARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection. Cell Reports. 14:2389-2401.CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral InfectionJournal of Molecular and Cellular CardiologyCARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesity. Journal of Molecular and Cellular Cardiology. 92:185-195.CARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesityInfection and ImmunityAntifungal activity of plasmacytoid dendritic cells against Cryptococcus neoformans In Vitro requires expression of dectin-3 (CLEC4D) and reactive oxygen species. Infection and Immunity. 84:2493-2504.Antifungal activity of plasmacytoid dendritic cells against Cryptococcus neoformans In Vitro requires expression of dectin-3 (CLEC4D) and reactive oxygen speciesOncogeneMALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression. Oncogene. MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progressionMolecular Cancer ResearchThe CBM complex underwrites NF-κB activation to promote HER2-associated tumor malignancy. Molecular Cancer Research. 14:93-102.The CBM complex underwrites NF-κB activation to promote HER2-associated tumor malignancyProceedings of the National Academy of Sciences of the United States of AmericaErratum. Proceedings of the National Academy of Sciences of the United States of America. 104:2024.Erratum17020976Lin X, Gu J, Lu C, Spitz MR, Wu XClinical cancer research : an official journal of the American Association for Cancer ResearchExpression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer. Clin Cancer Res. 2006 Oct 01; 12(19):5720-5.Clin Cancer Res2006-10-01T00:00:002006Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer.21123948Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui XThe Journal of clinical investigationThioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-?B signaling. J Clin Invest. 2011 Jan; 121(1):212-25.J Clin Invest2010-12-01T00:00:002010Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-?B signaling.D048868Chemicals & Drugs64914280.606259Adaptor Proteins, Signal TransducingD016328Chemicals & DrugsPhysiology60215430.590431NF-kappa BD037181Chemicals & Drugs1071610.919793Lectins, C-TypeD015398Physiology1881119620.270767Signal TransductionD053468Chemicals & Drugs671120.921342CARD Signaling Adaptor ProteinsImmunologyUrologyDepartment of Pathology & ImmunologyPathologyBaylor College of MedicineMARTINMATZUKMARTIN MATZUK0.000000000000000.000000000000001976MATZUK, MARTINProfessortrue1ProfessorProfessorAuthorship 10801281437756564Yao T, Zhang Z, Li Q, Huang R, Hong Y, Li C, Zhang F, Huang Y, Fang Y, Cao Q, Jin X, Li C, Wang Z, Lin XJ, Li L, Wei W, Wang Z, Shen JCancer immunology researchLong-Read Sequencing Reveals Alternative Splicing-Driven, Shared Immunogenic Neoepitopes Regardless of SF3B1 Status in Uveal Melanoma. Cancer Immunol Res. 2023 12 01; 11(12):1671-1687.Cancer Immunol Res2023-12-01T00:00:002023Long-Read Sequencing Reveals Alternative Splicing-Driven, Shared Immunogenic Neoepitopes Regardless of SF3B1 Status in Uveal Melanoma.true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessor