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IZABELA FOKT

TitleInstructor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1901 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Soltyka-Krajewska M, Ziemniak M, Zawadzka-Kazimierczuk A, Skrzypczyk P, Siwiak-Niedbalska E, Jaskiewicz A, Zielinski R, Fokt I, Sk?ra S, Kozminski W, Wozniak K, Priebe W, Pajak-Tarnacka B. Potent Biological Activity of Fluorinated Derivatives of 2-Deoxy-d-Glucose in a Glioblastoma Model. Biomedicines. 2024 Oct 01; 12(10). PMID: 39457553; PMCID: PMC11504489.
      Citations:    
    2. Fokt I, Cybulski M, Skora S, Pajak B, Ziemniak M, Wozniak K, Zielinski R, Priebe W. d-Glucose- and d-mannose-based antimetabolites. Part 4: Facile synthesis of mono- and di-acetates of 2-deoxy-d-glucose prodrugs as potentially useful antimetabolites. Carbohydr Res. 2023 Sep; 531:108861. PMID: 37356236.
      Citations: 1     Fields:    
    3. Pajak B, Zielinski R, Manning JT, Matejin S, Paessler S, Fokt I, Emmett MR, Priebe W. The Antiviral Effects of 2-Deoxy-D-glucose (2-DG), a Dual D-Glucose and D-Mannose Mimetic, against SARS-CoV-2 and Other Highly Pathogenic Viruses. Molecules. 2022 Sep 12; 27(18). PMID: 36144664; PMCID: PMC9503362.
      Citations:    
    4. Ziemniak M, Pawledzio S, Zawadzka-Kazimierczuk A, Dominiak PM, Trzybinski D, Kozminski W, Zielinski R, Fokt I, Priebe W, Wozniak K, Pajak B. Correction: X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-d-glucose in solid state and solution. RSC Adv. 2022 Mar 31; 12(17):10306. PMID: 35427095; PMCID: PMC8972390.
      Citations:    
    5. Ziemniak M, Pawledzio S, Zawadzka-Kazmierczuk A, Dominiak PM, Trzybinski D, Kozminski W, Zielinski R, Fokt I, Priebe W, Wozniak K, Pajak B. X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-d-glucose in solid state and solution. RSC Adv. 2022 03 15; 12(14):8345-8360. PMID: 35424802; PMCID: PMC8985090.
      Citations:    
    6. Pajak B, Siwiak-Niedbalska E, Jaskiewicz A, Soltyka M, Zielinski R, Domoradzki T, Fokt I, Priebe W, Sk?ra S. Synergistic Anticancer Effect of Glycolysis and Histone Deacetylases Inhibitors in a Glioblastoma Model. Biomedicines. 2021 Nov 23; 9(12). PMID: 34944565; PMCID: PMC8698815.
      Citations: 2     
    7. Ziemniak M, Zawadzka-Kazimierczuk A, Pawledzio S, Malinska M, Soltyka M, Trzybinski D, Kozminski W, Skora S, Zielinski R, Fokt I, Priebe W, Wozniak K, Pajak B. Experimental and Computational Studies on Structure and Energetic Properties of Halogen Derivatives of 2-Deoxy-D-Glucose. Int J Mol Sci. 2021 Apr 02; 22(7). PMID: 33918425; PMCID: PMC8038202.
      Citations: 1     Fields:    Translation:Cells
    8. Sharma P, Roberts C, Herpai D, Fokt ID, Priebe W, Debinski W. Drug Conjugates for Targeting Eph Receptors in Glioblastoma. Pharmaceuticals (Basel). 2020 Apr 23; 13(4). PMID: 32340173; PMCID: PMC7243104.
      Citations: 2     
    9. Pajak B, Siwiak E, Soltyka M, Priebe A, Zielinski R, Fokt I, Ziemniak M, Jaskiewicz A, Borowski R, Domoradzki T, Priebe W. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019 Dec 29; 21(1). PMID: 31905745; PMCID: PMC6982256.
      Citations:    
    10. Sonawane P, Choi YA, Pandya H, Herpai DM, Fokt I, Priebe W, Debinski W. Novel Molecular Multilevel Targeted Antitumor Agents. Cancer Transl Med. 2017 May-Jun; 3(3):69-79. PMID: 28825042; PMCID: PMC5558462.
      Citations: 5     
    11. Olbryt M, Rusin A, Fokt I, Habryka A, Tudrej P, Student S, Sochanik A, Zielinski R, Priebe W. Bis-anthracycline WP760 abrogates melanoma cell growth by transcription inhibition, p53 activation and IGF1R downregulation. Invest New Drugs. 2017 Oct; 35(5):545-555. PMID: 28417283; PMCID: PMC5613070.
      Citations: 1     Fields:    Translation:HumansCells
    12. Lamhamedi-Cherradi SE, Menegaz BA, Ramamoorthy V, Vishwamitra D, Wang Y, Maywald RL, Buford AS, Fokt I, Skora S, Wang J, Naing A, Lazar AJ, Rohren EM, Daw NC, Subbiah V, Benjamin RS, Ratan R, Priebe W, Mikos AG, Amin HM, Ludwig JA. IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma. J Natl Cancer Inst. 2016 12; 108(12). PMID: 27576731; PMCID: PMC5241894.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    13. Mielecki M, Krawiec K, Kiburu I, Grzelak K, Kierdaszuk B, Kowa K, Fokt I, Szymanski S, Swierk P, Szeja W, Priebe W, Lesyng B, LaRonde-LeBlanc N, Zag?rski W. Development of novel molecular probes of the Rio1 atypical protein kinase. Biochim Biophys Acta. 2013 Jul; 1834(7):1292-301. PMID: 23523885.
      Citations: 8     Fields:    Translation:Cells
    14. Fokt I, Skora S, Conrad C, Madden T, Emmett M, Priebe W. D-Glucose and D-mannose-based metabolic probes. Part 3: Synthesis of specifically deuterated D-glucose, D-mannose, and 2-deoxy-D-glucose. Carbohydr Res. 2013 Mar 07; 368:111-9. PMID: 23376241; PMCID: PMC3893820.
      Citations: 2     Fields:    Translation:Cells
    15. Swiatek-Machado K, Mieczkowski J, Ellert-Miklaszewska A, Swierk P, Fokt I, Szymanski S, Skora S, Szeja W, Grynkiewicz G, Lesyng B, Priebe W, Kaminska B. Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells. Cancer Biol Ther. 2012 Jun; 13(8):657-70. PMID: 22555804.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    16. Sai K, Wang S, Balasubramaniyan V, Conrad C, Lang FF, Aldape K, Szymanski S, Fokt I, Dasgupta A, Madden T, Guan S, Chen Z, Alfred Yung WK, Priebe W, Colman H. Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J Neurooncol. 2012 May; 107(3):487-501. PMID: 22249692.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    17. Yan H, Chen X, Zhang Q, Qin J, Li H, Liu C, Calhoun-Davis T, Coletta LD, Klostergaard J, Fokt I, Skora S, Priebe W, Bi Y, Tang DG. Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms. PLoS One. 2011; 6(9):e24397. PMID: 21935404; PMCID: PMC3174165.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    18. Ahmed AA, Goldsmith J, Fokt I, Le XF, Krzysko KA, Lesyng B, Bast RC, Priebe W. A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer. Cancer Chemother Pharmacol. 2011 Oct; 68(4):1033-44. PMID: 21340606; PMCID: PMC3180612.
      Citations: 3     Fields:    Translation:HumansCells
    19. Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB. Hypoxia potentiates glioma-mediated immunosuppression. PLoS One. 2011 Jan 20; 6(1):e16195. PMID: 21283755; PMCID: PMC3024401.
      Citations: 94     Fields:    Translation:HumansCells
    20. Sandulache VC, Ow TJ, Pickering CR, Frederick MJ, Zhou G, Fokt I, Davis-Malesevich M, Priebe W, Myers JN. Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer. 2011 Jul 01; 117(13):2926-38. PMID: 21692052; PMCID: PMC3135768.
      Citations: 64     Fields:    Translation:HumansCells
    21. Kong LY, Gelbard A, Wei J, Reina-Ortiz C, Wang Y, Yang EC, Hailemichael Y, Fokt I, Jayakumar A, Qiao W, Fuller GN, Overwijk WW, Priebe W, Heimberger AB. Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model. Clin Cancer Res. 2010 May 01; 16(9):2550-61. PMID: 20388845; PMCID: PMC2936966.
      Citations: 23     Fields:    Translation:AnimalsCells
    22. Fokt I, Szymanski S, Skora S, Cybulski M, Madden T, Priebe W. D-glucose- and D-mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2-halo-D-glucoses and -D-mannoses. Carbohydr Res. 2009 Aug 17; 344(12):1464-73. PMID: 19625015.
      Citations: 5     Fields:    Translation:Cells
    23. Kong LY, Wei J, Sharma AK, Barr J, Abou-Ghazal MK, Fokt I, Weinberg J, Rao G, Grimm E, Priebe W, Heimberger AB. A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells. Cancer Immunol Immunother. 2009 Jul; 58(7):1023-32. PMID: 19002459; PMCID: PMC2674523.
      Citations: 42     Fields:    Translation:HumansCells
    24. Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, Qiao W, Fuller GN, Fokt I, Grimm EA, Schmittling RJ, Archer GE, Sampson JH, Priebe W, Heimberger AB. A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin Cancer Res. 2008 Sep 15; 14(18):5759-68. PMID: 18794085; PMCID: PMC2583362.
      Citations: 68     Fields:    Translation:AnimalsCells
    25. Korchowiec B, Korchowiec J, Badis M, Mironiuk-Puchalska E, Fokt I, Priebe W, Rogalska E, Corvis Y. Complexation of metal ions in Langmuir films formed with two amphiphilic dioxadithia crown ethers. J Phys Chem B. 2008 Sep 04; 112(35):10953-63. PMID: 18698707.
      Citations: 1     Fields:    
    26. Gruber BM, Anuszewska EL, Bubko I, Kasprzycka-Guttman T, Misiewicz I, Skupinska K, Fokt I, Piebe W. NFkappaB activation and drug sensitivity in human neoplastic cells treated with anthracyclines. Acta Pol Pharm. 2008 Mar-Apr; 65(2):267-71. PMID: 18666436.
      Citations: 1     Fields:    Translation:HumansCells
    27. Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, Priebe W, Heimberger AB. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res. 2007 Oct 15; 67(20):9630-6. PMID: 17942891.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    28. Gruber BM, Anuszewska EL, Bubko I, Gozdzik A, Fokt I, Priebe W. Effect of structural modification at the 4, 3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells. Arch Immunol Ther Exp (Warsz). 2007 May-Jun; 55(3):193-8. PMID: 17557149; PMCID: PMC2765644.
      Citations: 2     Fields:    Translation:HumansCells
    29. Bidwell GL, Davis AN, Fokt I, Priebe W, Raucher D. A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance. Invest New Drugs. 2007 Aug; 25(4):313-26. PMID: 17483874.
      Citations: 48     Fields:    Translation:HumansCells
    30. Zheng M, Priebe W, Walch ET, Roth KG, Han M, Tang CH, Lee S, Poindexter NJ, Fokt I, Grimm EA. WP760, a melanoma selective drug. Cancer Chemother Pharmacol. 2007 Oct; 60(5):625-33. PMID: 17195067.
      Citations: 4     Fields:    Translation:HumansCells
    31. Bidwell GL, Fokt I, Priebe W, Raucher D. Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin. Biochem Pharmacol. 2007 Mar 01; 73(5):620-31. PMID: 17161827.
      Citations: 47     Fields:    Translation:HumansCells
    32. Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, Hess K, Conrad C, Madden T, Sawaya R, Kondo S, Priebe W, Kondo Y. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. 2007 Apr 12; 26(17):2435-44. PMID: 17043651.
      Citations: 171     Fields:    Translation:HumansCells
    33. Lampidis TJ, Kurtoglu M, Maher JC, Liu H, Krishan A, Sheft V, Szymanski S, Fokt I, Rudnicki WR, Ginalski K, Lesyng B, Priebe W. Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells". Cancer Chemother Pharmacol. 2006 Dec; 58(6):725-34. PMID: 16555088.
      Citations: 29     Fields:    Translation:HumansCells
    34. Gruber BM, Anuszewska EL, Roman I, Gozdzik A, Priebe W, Fokt I. Topoisomerase II alpha expression and cytotoxicity of anthracyclines in human neoplastic cells. Acta Pol Pharm. 2006 Jan-Feb; 63(1):15-8. PMID: 17515324.
      Citations: 1     Fields:    Translation:HumansCells
    35. Cashman DJ, Trent JO, Ferrer-Miralles N, Przewloka T, Fokt I, Priebe W, Chaires JB, Portugal J. A new bisintercalating anthracycline with picomolar DNA binding affinity. J Med Chem. 2005 Dec 29; 48(26):8209-19. PMID: 16366602; PMCID: PMC2522373.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    36. Gruber BM, Anuszewska EL, Bubko I, Gozdzik A, Priebe W, Fokt I. Relationship between topoisomerase II-DNA cleavable complexes, apoptosis and cytotoxic activity of anthracyclines in human cervix carcinoma cells. Anticancer Res. 2005 May-Jun; 25(3B):2193-8. PMID: 16158963.
      Citations: 2     Fields:    Translation:HumansCells
    37. Gruber BM, Anuszewska EL, Bubko I, Kasprzycka-Guttman T, Misiewicz I, Skupinska K, Priebe W, Fokt I. Constitutive activation of transcription factor NFkappaB as a possible marker of sensitivity of neoplastic cells to anthracyclines. Acta Pol Pharm. 2005 Jan-Feb; 62(1):17-23. PMID: 16022489.
      Citations:    Fields:    Translation:Cells
    38. Nair RR, Wang H, Jamaluddin MS, Fokt I, Priebe W, Boyd DD. A bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region. Oncol Res. 2005; 15(5):265-79. PMID: 16261846.
      Citations: 2     Fields:    Translation:HumansCells
    39. Fox KR, Webster R, Phelps RJ, Fokt I, Priebe W. Sequence selective binding of bis-daunorubicin WP631 to DNA. Eur J Biochem. 2004 Sep; 271(17):3556-66. PMID: 15317591.
      Citations:    Fields:    Translation:Cells
    40. Ashikawa K, Shishodia S, Fokt I, Priebe W, Aggarwal BB. Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. Biochem Pharmacol. 2004 Jan 15; 67(2):353-64. PMID: 14698047.
      Citations: 23     Fields:    Translation:HumansCells
    41. Kruszewski M, Bouzyk E, Oldak T, Samochocka K, Fuks L, Lewandowski W, Fokt I, Priebe W. Differential toxic effect of cis-platinum(II) and palladium(II) chlorides complexed with methyl 3,4-diamine-2,3,4,6-tetradeoxy-alpha-L-lyxo-hexopyranoside in mouse lymphoma cell lines differing in DSB and NER repair ability. Teratog Carcinog Mutagen. 2003; Suppl 1:1-11. PMID: 12616592.
      Citations: 2     Fields:    Translation:AnimalsCells
    42. Przewloka T, Fokt I, Priebe W, Garnier-Suillerot A, Salerno M. Preferential efflux by P-glycoprotein, but not MRP1, of compounds containing a free electron donor amine. Biochem Pharmacol. 2002 Apr 15; 63(8):1471-9. PMID: 11996888.
      Citations: 1     Fields:    Translation:HumansCells
    43. Faderl S, Estrov Z, Kantarjian HM, Harris D, Van Q, Fokt I, Przewloka T, Godlewski C, Woynarowski JM, Priebe W. WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity. Anticancer Res. 2001 Nov-Dec; 21(6A):3777-84. PMID: 11911247.
      Citations: 2     Fields:    Translation:HumansCells
    44. Marbeuf-Gueye C, Salerno M, Loetchutinat C, Fokt I, Krawczyk M, Kowalczyk T, Priebe W, Garnier-Suillerot A. Analysis of drug transport kinetics in multidrug-resistant cells: implications for drug action. Curr Med Chem. 2001 Jan; 8(1):51-64. PMID: 11172692.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    45. Pratesi G, Monestiroli SV. Preclinical evaluation of new anthracyclines. Curr Med Chem. 2001 Jan; 8(1):9-13. PMID: 11172688.
      Citations:    Fields:    Translation:HumansAnimalsCells
    46. Priebe W, Fokt I, Przewloka T, Chaires JB, Portugal J, Trent JO. Exploiting anthracycline scaffold for designing DNA-targeting agents. Methods Enzymol. 2001; 340:529-55. PMID: 11494869.
      Citations: 13     Fields:    Translation:HumansCells
    47. Qu X, Trent JO, Fokt I, Priebe W, Chaires JB. Allosteric, chiral-selective drug binding to DNA. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12032-7. PMID: 11027298; PMCID: PMC17289.
      Citations: 30     Fields:    Translation:Cells
    48. Chaires JB, Leng F, Przewloka T, Fokt I, Ling YH, Perez-Soler R, Priebe W. Structure-based design of a new bisintercalating anthracycline antibiotic. J Med Chem. 1997 Jan 31; 40(3):261-6. PMID: 9022792.
      Citations: 12     Fields:    Translation:HumansCells
    49. Chaires JB, Satyanarayana S, Suh D, Fokt I, Przewloka T, Priebe W. Parsing the free energy of anthracycline antibiotic binding to DNA. Biochemistry. 1996 Feb 20; 35(7):2047-53. PMID: 8652545.
      Citations: 31     Fields:    Translation:AnimalsCells
    50. Synthesis 1-thioglycosides from 1-sulfenates. Carbohydrate Research. 232:169-175.
    51. Benzylation of sugar polyols by means of the PTC method. 108:224-226.
    52. Base specific and regioselective chemical cross-linking of daunorubicin to DNA. Journal of the American Chemical Society. 118:4731-4738.
    53. Syntheses of thioglycofuranosides. Carbohydrate Letters. 3:191-197.
    54. Synthesis of sulfenates of sugar derivatives. Carbohydrate Research. 222:271-276.
    55. Base specific and regioselective chemical cross-linking of daunorubicin to DNA. Journal of the American Chemical Society. 118.
    56. Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent anti-tumor activity in glioma cells. Cancer Biology and Therapy. 13:658-671.
    57. N-Chlorophthalimide as a mild and efficient chlorination reagent in the Gassman ortho alkylation of aromatic amines. Synthesis of 3-(methylthio)oxindoles. Tetrahedron Letters. 55:5423-5425.
    58. Parsing the free energy of anthracycline antibiotic binding to DNA. Biochemistry. 35.
    59. New strategies towards synthesis of doxorubicin analogs. Polish Journal of Chemistry. 79:349-359.
    60. Platinum(II) and palladium(II) complexes with methyl 3,4-diamino-2,3,4,6- tetradeoxy-α-L-lyxo-hexopyranoside. Dalton Transactions. 2177-2183.
    61. Bromine atom interactions in biologically active acrylamide derivatives. Crystal Growth and Design. 15:2632-2642.
    62. Synthesis of 1-O-silylated 3-azido- and 3-N-trifluoroacetamido-2,3,6- trideoxy-L-arabino and L-lyxo-hexopyranoses, convenient glycosyl donors for preparation of anthracycline antibiotics and related DNA-binding agents. Polish Journal of Chemistry. 79:335-347.
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