DOUGLAS DBOYDDOUGLAS D BOYD8569BOYD, DOUGLAS DProfessorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson7777 Knight RdHouston77054-3005TXAuthorship 1646107Authorship 1648324Authorship 1650644Authorship 1654157Authorship 1656549Authorship 1656595Authorship 1664716Authorship 1665106Authorship 1675588Authorship 1676643Authorship 1676887Authorship 1697562Authorship 1714353Authorship 1719514Authorship 1739435Authorship 1747236Authorship 1753624Authorship 1754251Authorship 17640211Authorship 1772478Authorship 1793748Authorship 1795447Authorship 1845194Authorship 1869185Authorship 18716410Authorship 1887222Authorship 195977137559439Lengyel E, Stepp E, Gum R, Boyd DThe Journal of biological chemistryInvolvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras. J Biol Chem. 1995 Sep 29; 270(39):23007-12.J Biol Chem1995-09-29T00:00:001995Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.8631874Gum R, Lengyel E, Juarez J, Chen JH, Sato H, Seiki M, Boyd DThe Journal of biological chemistryStimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences. J Biol Chem. 1996 May 03; 271(18):10672-80.J Biol Chem1996-05-03T00:00:001996Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.8761947Lengyel E, Gum R, Stepp E, Juarez J, Wang H, Boyd DJournal of cellular biochemistryRegulation of urokinase-type plasminogen activator expression by an ERK1-dependent signaling pathway in a squamous cell carcinoma cell line. J Cell Biochem. 1996 Jun 01; 61(3):430-43.J Cell Biochem1996-06-01T00:00:001996Regulation of urokinase-type plasminogen activator expression by an ERK1-dependent signaling pathway in a squamous cell carcinoma cell line.9818827Simon C, Nemechek AJ, Boyd D, O'Malley BW, Goepfert H, Flaitz CM, Hicks MJThe LaryngoscopeAn orthotopic floor-of-mouth cancer model allows quantification of tumor invasion. Laryngoscope. 1998 Nov; 108(11 Pt 1):1686-91.Laryngoscope1998-11-01T00:00:001998An orthotopic floor-of-mouth cancer model allows quantification of tumor invasion.10373450Allgayer H, Wang H, Gallick GE, Crabtree A, Mazar A, Jones T, Kraker AJ, Boyd DDThe Journal of biological chemistryTranscriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1. J Biol Chem. 1999 Jun 25; 274(26):18428-37.J Biol Chem1999-06-25T00:00:001999Transcriptional induction of the urokinase receptor gene by a constitutively active Src. Requirement of an upstream motif (-152/-135) bound with Sp1.11792711Yan C, Wang H, Boyd DDThe Journal of biological chemistryATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter. J Biol Chem. 2002 Mar 29; 277(13):10804-12.J Biol Chem2002-01-15T00:00:002002ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter.14977859Boyd DD, Wang H, Avila H, Parikh NU, Kessler H, Magdolen V, Gallick GEClinical cancer research : an official journal of the American Association for Cancer ResearchCombination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness. Clin Cancer Res. 2004 Feb 15; 10(4):1545-55.Clin Cancer Res2004-02-15T00:00:002004Combination of an SRC kinase inhibitor with a novel pharmacological antagonist of the urokinase receptor diminishes in vitro colon cancer invasiveness.15933712Yan C, Lu D, Hai T, Boyd DDThe EMBO journalActivating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J. 2005 Jul 06; 24(13):2425-35.EMBO J2005-06-02T00:00:002005Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.16140945Bauer TW, Liu W, Fan F, Camp ER, Yang A, Somcio RJ, Bucana CD, Callahan J, Parry GC, Evans DB, Boyd DD, Mazar AP, Ellis LMCancer researchTargeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice. Cancer Res. 2005 Sep 01; 65(17):7775-81.Cancer Res2005-09-01T00:00:002005Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice.16912170Yang L, Avila H, Wang H, Trevino J, Gallick GE, Kitadai Y, Sasaki T, Boyd DDCancer researchPlasticity in urokinase-type plasminogen activator receptor (uPAR) display in colon cancer yields metastable subpopulations oscillating in cell surface uPAR density--implications in tumor progression. Cancer Res. 2006 Aug 15; 66(16):7957-67.Cancer Res2006-08-15T00:00:002006Plasticity in urokinase-type plasminogen activator receptor (uPAR) display in colon cancer yields metastable subpopulations oscillating in cell surface uPAR density--implications in tumor progression.18065684Nair RR, Avila H, Ma X, Wang Z, Lennartz M, Darnay BG, Boyd DD, Yan CMolecular pharmacologyA novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression. Mol Pharmacol. 2008 Mar; 73(3):919-29.Mol Pharmacol2007-12-07T00:00:002007A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression.18519692Yang L, Hamilton SR, Sood A, Kuwai T, Ellis L, Sanguino A, Lopez-Berestein G, Boyd DDCancer researchThe previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression. Cancer Res. 2008 Jun 01; 68(11):4321-30.Cancer Res2008-06-01T00:00:002008The previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression.21496842del Junco DJ, Fox EE, Cooper S, Goldhagen M, Koda E, Rogers D, Canby-Hagino E, Kim J, Pettaway C, Boyd DDThe Journal of urologyIncreasing low risk prostate cancer incidence in United States Air Force servicemen and selection of treatments. J Urol. 2011 Jun; 185(6):2137-42.J Urol2011-04-15T00:00:002011Increasing low risk prostate cancer incidence in United States Air Force servicemen and selection of treatments.21937508Chauhan S, Boyd DDNucleic acids researchRegulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway. Nucleic Acids Res. 2012 Jan; 40(2):600-13.Nucleic Acids Res2011-09-21T00:00:002011Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway.Bioinformatics & Computational BiologyCancer BiologyGenitourinary Medical OncologyGynecological Oncology & Reproductive MedicineLeukemiaMolecular & Cellular OncologySurgical OncologySystems BiologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorJERIKIMJERI KIM8669KIM, JERIProfessorASHISHKAMATASHISH KAMAT8961KAMAT, ASHISHProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorGORDON BMILLSGORDON B MILLS8620MILLS, GORDON BProfessor2.775530.00310022436research areas0.6511450.010081323coauthor of36.814610.367760similar to1188selected publicationsLEE MELLISLEE M ELLIS8478ELLIS, LEE MProfessorGARY EGALLICKGARY E GALLICK8518GALLICK, GARY EProfessorJINGWANGJING WANG8910WANG, JINGAssociate ProfessorANIL KSOODANIL K SOOD9048SOOD, ANIL KProfessorAuthorship 2120842Authorship 2124731Authorship 2127991Authorship 2143367Authorship 2144413Authorship 2146404Authorship 2150891Authorship 2156708Authorship 2162444Authorship 2166337Authorship 2170435Authorship 2171833Authorship 2171886Authorship 2175402Authorship 2197774Authorship 2198994Authorship 2203831Authorship 2209571Authorship 2233495Authorship 23376871653586Hoosein NM, Boyd DD, Hollas WJ, Mazar A, Henkin J, Chung LWCancer communicationsInvolvement of urokinase and its receptor in the invasiveness of human prostatic carcinoma cell lines. Cancer Commun. 1991 Aug; 3(8):255-64.Cancer Commun1991-08-01T00:00:001991Involvement of urokinase and its receptor in the invasiveness of human prostatic carcinoma cell lines.3111681Boyd D, Bialoski S, Brattain MGCancer researchEffects of difluoromethylornithine and dicyclohexylammonium sulfate on the transformed state of AKR-MCA cells. Cancer Res. 1987 Aug 01; 47(15):4099-104.Cancer Res1987-08-01T00:00:001987Effects of difluoromethylornithine and dicyclohexylammonium sulfate on the transformed state of AKR-MCA cells.3281751Boyd DD, Levine AE, Brattain DE, McKnight MK, Brattain MGCancer researchComparison of growth requirements of two human intratumoral colon carcinoma cell lines in monolayer and soft agarose. Cancer Res. 1988 May 01; 48(9):2469-74.Cancer Res1988-05-01T00:00:001988Comparison of growth requirements of two human intratumoral colon carcinoma cell lines in monolayer and soft agarose.7626664Lengyel E, Klostergaard J, Boyd DBiochimica et biophysica actaStimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors. Biochim Biophys Acta. 1995 Jul 20; 1268(1):65-72.Biochim Biophys Acta1995-07-20T00:00:001995Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors.7653995Gum R, Wang SW, Lengyel E, Yu D, Hung MC, Juarez J, Boyd DAnticancer researchUp-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene. Anticancer Res. 1995 Jul-Aug; 15(4):1167-72.Anticancer Res1995-07-01T00:00:001995Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.7779611Boyd DD, Nicolson GLCancer treatment and researchMechanisms of invasion by head and neck cancers. Cancer Treat Res. 1995; 74:117-30.Cancer Treat Res1995-01-01T00:00:001995Mechanisms of invasion by head and neck cancers.8077048Wang H, Skibber J, Juarez J, Boyd DInternational journal of cancerTranscriptional activation of the urokinase receptor gene in invasive colon cancer. Int J Cancer. 1994 Sep 01; 58(5):650-7.Int J Cancer1994-09-01T00:00:001994Transcriptional activation of the urokinase receptor gene in invasive colon cancer.8798512Lengyel E, Wang H, Stepp E, Juarez J, Wang Y, Doe W, Pfarr CM, Boyd DThe Journal of biological chemistryRequirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene. J Biol Chem. 1996 Sep 20; 271(38):23176-84.J Biol Chem1996-09-20T00:00:001996Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene.8968087Simon C, Juarez J, Nicolson GL, Boyd DCancer researchEffect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion. Cancer Res. 1996 Dec 01; 56(23):5369-74.Cancer Res1996-12-01T00:00:001996Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion.9136992Gum R, Wang H, Lengyel E, Juarez J, Boyd DOncogeneRegulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades. Oncogene. 1997 Mar 27; 14(12):1481-93.Oncogene1997-03-27T00:00:001997Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades.9674706Gum R, Juarez J, Allgayer H, Mazar A, Wang Y, Boyd DOncogeneStimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and -independent signaling modules. Oncogene. 1998 Jul 16; 17(2):213-25.Oncogene1998-07-16T00:00:001998Stimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and -independent signaling modules.10415733Zucker S, Hymowitz M, Conner C, Zarrabi HM, Hurewitz AN, Matrisian L, Boyd D, Nicolson G, Montana SAnnals of the New York Academy of SciencesMeasurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications. Ann N Y Acad Sci. 1999 Jun 30; 878:212-27.Ann N Y Acad Sci1999-06-30T00:00:001999Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications.10447677Dang J, Boyd D, Wang H, Allgayer H, Doe WF, Wang YEuropean journal of biochemistryA region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor. Eur J Biochem. 1999 Aug; 264(1):92-9.Eur J Biochem1999-08-01T00:00:001999A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor.11115541Lakka SS, Bhattacharya A, Mohanam S, Boyd D, Rao JSInternational journal of oncologyRegulation of the uPA gene in various grades of human glioma cells. Int J Oncol. 2001 Jan; 18(1):71-9.Int J Oncol2001-01-01T00:00:002001Regulation of the uPA gene in various grades of human glioma cells.11196194Mazumdar A, Adam L, Boyd D, Kumar RCancer researchHeregulin regulation of urokinase plasminogen activator and its receptor: human breast epithelial cell invasion. Cancer Res. 2001 Jan 01; 61(1):400-5.Cancer Res2001-01-01T00:00:002001Heregulin regulation of urokinase plasminogen activator and its receptor: human breast epithelial cell invasion.12105194Sanc?au J, Boyd DD, Seiki M, Bauvois BThe Journal of biological chemistryInterferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B. J Biol Chem. 2002 Sep 20; 277(38):35766-75.J Biol Chem2002-07-08T00:00:002002Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B.12431981Yan C, Wang H, Toh Y, Boyd DDThe Journal of biological chemistryRepression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation. J Biol Chem. 2003 Jan 24; 278(4):2309-16.J Biol Chem2002-11-12T00:00:002002Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation.15316047Boyd DD, Nakajima MJournal of the National Cancer InstituteInvolvement of heparanase in tumor metastases: a new target in cancer therapy? J Natl Cancer Inst. 2004 Aug 18; 96(16):1194-5.J Natl Cancer Inst2004-08-18T00:00:002004Involvement of heparanase in tumor metastases: a new target in cancer therapy?17001307Wang H, Yan C, Asangani I, Allgayer H, Boyd DDOncogeneIdentification of an histone H3 acetylated/K4-methylated-bound intragenic enhancer regulatory for urokinase receptor expression. Oncogene. 2007 Mar 29; 26(14):2058-70.Oncogene2006-09-25T00:00:002006Identification of an histone H3 acetylated/K4-methylated-bound intragenic enhancer regulatory for urokinase receptor expression.23434374Chauhan S, Goodwin JG, Chauhan S, Manyam G, Wang J, Kamat AM, Boyd DDMolecular cellZKSCAN3 is a master transcriptional repressor of autophagy. Mol Cell. 2013 Apr 11; 50(1):16-28.Mol Cell2013-02-21T00:00:002013ZKSCAN3 is a master transcriptional repressor of autophagy.Authorship 2361823Authorship 2395041Authorship 2405854Authorship 2409843Authorship 2418886Authorship 2425953Authorship 2427144Authorship 2442587Authorship 2448054Authorship 2449713Authorship 2479262Authorship 2483362Authorship 2487082Authorship 2487932Authorship 2488312Authorship 2541016Authorship 2554194Authorship 2594732Authorship 26224221648443Hollas W, Blasi F, Boyd DCancer researchRole of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer. Cancer Res. 1991 Jul 15; 51(14):3690-5.Cancer Res1991-07-15T00:00:001991Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.8391387Karik? K, Kuo A, Boyd D, Okada SS, Cines DB, Barnathan ESCancer researchOverexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. Cancer Res. 1993 Jul 01; 53(13):3109-17.Cancer Res1993-07-01T00:00:001993Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line.8842480Boyd DCancer metastasis reviewsInvasion and metastasis. Cancer Metastasis Rev. 1996 Mar; 15(1):77-89.Cancer Metastasis Rev1996-03-01T00:00:001996Invasion and metastasis.9515796Simon C, Goepfert H, Boyd DCancer researchInhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion. Cancer Res. 1998 Mar 15; 58(6):1135-9.Cancer Res1998-03-15T00:00:001998Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.9762344Nicolson GL, Nakajima M, Wakabayashi H, Boyd DD, Diaz D, Irimura TAdvances in enzyme regulationCancer cell heparanase activity associated with invasion and metastasis. Adv Enzyme Regul. 1998; 38:19-32.Adv Enzyme Regul1998-01-01T00:00:001998Cancer cell heparanase activity associated with invasion and metastasis.10824110Wang Y, Dang J, Wang H, Allgayer H, Murrell GA, Boyd DEuropean journal of biochemistryIdentification of a novel nuclear factor-kappaB sequence involved in expression of urokinase-type plasminogen activator receptor. Eur J Biochem. 2000 Jun; 267(11):3248-54.Eur J Biochem2000-06-01T00:00:002000Identification of a novel nuclear factor-kappaB sequence involved in expression of urokinase-type plasminogen activator receptor.11060311Yan C, Wang H, Boyd DDThe Journal of biological chemistryKiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha -induced block of p65/p50 nuclear translocation. J Biol Chem. 2001 Jan 12; 276(2):1164-72.J Biol Chem2001-01-12T00:00:002001KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Balpha -induced block of p65/p50 nuclear translocation.11234878Bhattacharya A, Lakka SS, Mohanam S, Boyd D, Rao JSClinical cancer research : an official journal of the American Association for Cancer ResearchRegulation of the urokinase-type plasminogen activator receptor gene in different grades of human glioma cell lines. Clin Cancer Res. 2001 Feb; 7(2):267-76.Clin Cancer Res2001-02-01T00:00:002001Regulation of the urokinase-type plasminogen activator receptor gene in different grades of human glioma cell lines.12165859Lakka SS, Jasti SL, Gondi C, Boyd D, Chandrasekar N, Dinh DH, Olivero WC, Gujrati M, Rao JSOncogeneDownregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro. Oncogene. 2002 Aug 15; 21(36):5601-8.Oncogene2002-08-15T00:00:002002Downregulation of MMP-9 in ERK-mutated stable transfectants inhibits glioma invasion in vitro.12796395Schewe DM, Leupold JH, Boyd DD, Lengyel ER, Wang H, Gruetzner KU, Schildberg FW, Jauch KW, Allgayer HClinical cancer research : an official journal of the American Association for Cancer ResearchTumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers. Clin Cancer Res. 2003 Jun; 9(6):2267-76.Clin Cancer Res2003-06-01T00:00:002003Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers.12875967Wang H, Hicks J, Khanbolooki P, Kim SJ, Yan C, Wang Y, Boyd DThe American journal of pathologyTransgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene. Am J Pathol. 2003 Aug; 163(2):453-64.Am J Pathol2003-08-01T00:00:002003Transgenic mice demonstrate novel promoter regions for tissue-specific expression of the urokinase receptor gene.16246065Nair RR, Boyd DDBiochemical Society transactionsExpression cloning of novel regulators of 92 kDa type IV collagenase expression. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1135-6.Biochem Soc Trans2005-11-01T00:00:002005Expression cloning of novel regulators of 92 kDa type IV collagenase expression.16491955Borgatti M, Boyd DD, Lampronti I, Bianchi N, Fabbri E, Saviano M, Romanelli A, Pedone C, Gambari ROncology researchDecoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter. Oncol Res. 2005; 15(7-8):373-83.Oncol Res2005-01-01T00:00:002005Decoy molecules based on PNA-DNA chimeras and targeting Sp1 transcription factors inhibit the activity of urokinase-type plasminogen activator receptor (uPAR) promoter.16628010Yan C, Boyd DDCell cycle (Georgetown, Tex.)ATF3 regulates the stability of p53: a link to cancer. Cell Cycle. 2006 May; 5(9):926-9.Cell Cycle2006-05-01T00:00:002006ATF3 regulates the stability of p53: a link to cancer.16914722Yan C, Boyd DDMolecular and cellular biologyHistone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression. Mol Cell Biol. 2006 Sep; 26(17):6357-71.Mol Cell Biol2006-09-01T00:00:002006Histone H3 acetylation and H3 K4 methylation define distinct chromatin regions permissive for transgene expression.17167774Yan C, Boyd DDJournal of cellular physiologyRegulation of matrix metalloproteinase gene expression. J Cell Physiol. 2007 Apr; 211(1):19-26.J Cell Physiol2007-04-01T00:00:002007Regulation of matrix metalloproteinase gene expression.20087350Ishiguro T, Avila H, Lin SY, Nakamura T, Yamamoto M, Boyd DDBritish journal of cancerGene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases. Br J Cancer. 2010 Feb 16; 102(4):774-82.Br J Cancer2010-01-19T00:00:002010Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases.20592017Mo P, Wang H, Lu H, Boyd DD, Yan CThe Journal of biological chemistryMDM2 mediates ubiquitination and degradation of activating transcription factor 3. J Biol Chem. 2010 Aug 27; 285(35):26908-26915.J Biol Chem2010-06-30T00:00:002010MDM2 mediates ubiquitination and degradation of activating transcription factor 3.22097644Rogers D, Boyd DD, Fox EE, Cooper S, Goldhagen M, Shen Y, Del Junco DJAviation, space, and environmental medicineProstate cancer incidence in U.S. Air Force aviators compared with non-aviators. Aviat Space Environ Med. 2011 Nov; 82(11):1067-70.Aviat Space Environ Med2011-11-01T00:00:002011Prostate cancer incidence in U.S. Air Force aviators compared with non-aviators.Authorship 2627132Authorship 2630572Authorship 2633598Authorship 2643267Authorship 2645383Authorship 2656541Authorship 2662934Authorship 2667626Authorship 2672964Authorship 2681874Authorship 27210331337629Hollas W, Hoosein N, Chung LW, Mazar A, Henkin J, Kariko K, Barnathan ES, Boyd DThrombosis and haemostasisExpression of urokinase and its receptor in invasive and non-invasive prostate cancer cell lines. Thromb Haemost. 1992 Dec 07; 68(6):662-6.Thromb Haemost1992-12-07T00:00:001992Expression of urokinase and its receptor in invasive and non-invasive prostate cancer cell lines.1665597Hollas W, Boyd DThrombosis and haemostasisRegulation of the urokinase receptor by its plasminogen activator. Thromb Haemost. 1991 Dec 02; 66(6):678-83.Thromb Haemost1991-12-02T00:00:001991Regulation of the urokinase receptor by its plasminogen activator.2390419Schlechte JW, Boyd DDCancer communicationsInsensitivity of laminin degradation directed by receptor bound urokinase to PAI-1 in cultured colon cancer. Cancer Commun. 1990; 2(8):261-9.Cancer Commun1990-01-01T00:00:001990Insensitivity of laminin degradation directed by receptor bound urokinase to PAI-1 in cultured colon cancer.9403716Gohji K, Nakajima M, Boyd D, Dinney CP, Bucana CD, Kitazana S, Kamidono S, Fidler IJThe American journal of pathologyOrgan-site dependence for the production of urokinase-type plasminogen activator and metastasis by human renal cell carcinoma cells. Am J Pathol. 1997 Dec; 151(6):1655-61.Am J Pathol1997-12-01T00:00:001997Organ-site dependence for the production of urokinase-type plasminogen activator and metastasis by human renal cell carcinoma cells.9988707Allgayer H, Wang H, Wang Y, Heiss MM, Bauer R, Nyormoi O, Boyd DThe Journal of biological chemistryTransactivation of the urokinase-type plasminogen activator receptor gene through a novel promoter motif bound with an activator protein-2alpha-related factor. J Biol Chem. 1999 Feb 19; 274(8):4702-14.J Biol Chem1999-02-19T00:00:001999Transactivation of the urokinase-type plasminogen activator receptor gene through a novel promoter motif bound with an activator protein-2alpha-related factor.12547719Boyd DD, Kim SJ, Wang H, Jones TR, Gallick GEThe American journal of pathologyA urokinase-derived peptide (A6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis. Am J Pathol. 2003 Feb; 162(2):619-26.Am J Pathol2003-02-01T00:00:002003A urokinase-derived peptide (A6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis.14715692Yan C, Wang H, Aggarwal B, Boyd DDFASEB journal : official publication of the Federation of American Societies for Experimental BiologyA novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. FASEB J. 2004 Mar; 18(3):540-1.FASEB J2004-01-08T00:00:002004A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression.15537831Hill DA, Chiosea S, Jamaluddin S, Roy K, Fischer AH, Boyd DD, Nickerson JA, Imbalzano ANJournal of cell scienceInducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme. J Cell Sci. 2004 Nov 15; 117(Pt 24):5847-54.J Cell Sci2004-11-15T00:00:002004Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme.17170703Qi W, Wu H, Yang L, Boyd DD, Wang ZThe EMBO journalA novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression. EMBO J. 2007 Jan 10; 26(1):65-75.EMBO J2006-12-14T00:00:002006A novel function of caspase-8 in the regulation of androgen-receptor-driven gene expression.18940803Yang L, Zhang L, Wu Q, Boyd DDThe Journal of biological chemistryUnbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets. J Biol Chem. 2008 Dec 12; 283(50):35295-304.J Biol Chem2008-10-21T00:00:002008Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets.24919384Shao BS, Guindani M, Boyd DDAviation, space, and environmental medicineFatal accident rates for instrument-rated private pilots. Aviat Space Environ Med. 2014 Jun; 85(6):631-7.Aviat Space Environ Med2014-06-01T00:00:002014Fatal accident rates for instrument-rated private pilots.Authorship 2730593Authorship 27556161322138Hollas W, Soravia E, Mazar A, Henkin J, Blasi F, Boyd DThe Biochemical journalDecreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line. Biochem J. 1992 Jul 15; 285 ( Pt 2):629-34.Biochem J1992-07-15T00:00:001992Decreased urokinase receptor expression by overexpression of the plasminogen activator in a colon cancer cell line.16835221Nair RR, Solway J, Boyd DDThe Journal of biological chemistryExpression cloning identifies transgelin (SM22) as a novel repressor of 92-kDa type IV collagenase (MMP-9) expression. J Biol Chem. 2006 Sep 08; 281(36):26424-36.J Biol Chem2006-07-10T00:00:002006Expression cloning identifies transgelin (SM22) as a novel repressor of 92-kDa type IV collagenase (MMP-9) expression.7688350Juarez J, Clayman G, Nakajima M, Tanabe KK, Saya H, Nicolson GL, Boyd DInternational journal of cancerRole and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity. Int J Cancer. 1993 Aug 19; 55(1):10-8.Int J Cancer1993-08-19T00:00:001993Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity.7964975Rao JS, Steck PA, Tofilon P, Boyd D, Ali-Osman F, Stetler-Stevenson WG, Liotta LA, Sawaya RJournal of neuro-oncologyRole of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model. J Neurooncol. 1994; 18(2):129-38.J Neurooncol1994-01-01T00:00:001994Role of plasminogen activator and of 92-KDa type IV collagenase in glioblastoma invasion using an in vitro matrigel model.8386710Clayman G, Wang SW, Nicolson GL, el-Naggar A, Mazar A, Henkin J, Blasi F, Goepfert H, Boyd DDInternational journal of cancerRegulation of urokinase-type plasminogen activator expression in squamous-cell carcinoma of the oral cavity. Int J Cancer. 1993 Apr 22; 54(1):73-80.Int J Cancer1993-04-22T00:00:001993Regulation of urokinase-type plasminogen activator expression in squamous-cell carcinoma of the oral cavity.Authorship 302607126735230Boyd DD, Macchiarella NDAerospace medicine and human performanceOccupant Injury Severity and Accident Causes in Helicopter Emergency Medical Services (1983-2014). Aerosp Med Hum Perform. 2016 Jan; 87(1):26-31.Aerosp Med Hum Perform2016-01-01T00:00:002016Occupant Injury Severity and Accident Causes in Helicopter Emergency Medical Services (1983-2014).74Professor14Associate Professor47Distinguished Service Professor15713895Yan C, Jamaluddin MS, Aggarwal B, Myers J, Boyd DDMolecular cancer therapeuticsGene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol Cancer Ther. 2005 Feb; 4(2):233-41.Mol Cancer Ther2005-02-01T00:00:002005Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin.21143195Avila H, Wang H, Chauhan S, Hartig S, Boyd DDThe Biochemical journalAccelerated urokinase-receptor protein turnover triggered by interference with the addition of the glycolipid anchor. Biochem J. 2011 Mar 01; 434(2):233-42.Biochem J2011-03-01T00:00:002011Accelerated urokinase-receptor protein turnover triggered by interference with the addition of the glycolipid anchor.Authorship 843517Authorship 844805Authorship 846099Authorship 857947Authorship 861189Authorship 861610Authorship 864212Air Medical JournalShould Charity Air Medical Organizations Require Commercial Certification of Their Pilots?. Air Medical Journal. 34:188-194.Should Charity Air Medical Organizations Require Commercial Certification of Their Pilots?Head and NeckHead and neck. Head and Neck. 23:1021-1023.Head and neckInternational Journal of OncologyModulation of urokinase-type plasminogen activator expression by the wild-type and mutated p53 tumor suppressor gene. International Journal of Oncology. 7:143-146.Modulation of urokinase-type plasminogen activator expression by the wild-type and mutated p53 tumor suppressor geneEuropean Journal of CancerFirst clinical evidence of a combined AP-2/Sp1 promoter motif as a tumor-specific activator of urokinase-receptor (u-PAR) expression in resected gastreintestinal cancers. European Journal of Cancer. 37.First clinical evidence of a combined AP-2/Sp1 promoter motif as a tumor-specific activator of urokinase-receptor (u-PAR) expression in resected gastreintestinal cancersFibrinolysis and ProteolysisPlasminogen dependent laminin degradation and matrigel invasion by cultured colon cancer is directed by receptor-bound urokinase. Fibrinolysis and Proteolysis. 6:17-21.Plasminogen dependent laminin degradation and matrigel invasion by cultured colon cancer is directed by receptor-bound urokinaseFibrinolysis and ProteolysisDivergent effect of n,n-dimethylformamide on the expression of urokinase and its receptor. Fibrinolysis and Proteolysis. 7:149-157.Divergent effect of n,n-dimethylformamide on the expression of urokinase and its receptorAccident Analysis and PreventionGeneral aviation accidents related to exceedance of airplane weight/center of gravity limits. Accident Analysis and Prevention. 91:19-23.General aviation accidents related to exceedance of airplane weight/center of gravity limits7850814Lengyel E, Gum R, Juarez J, Clayman G, Seiki M, Sato H, Boyd DCancer researchInduction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts. Cancer Res. 1995 Feb 15; 55(4):963-7.Cancer Res1995-02-15T00:00:001995Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.8395977Mohanam S, Sawaya R, McCutcheon I, Ali-Osman F, Boyd D, Rao JSCancer researchModulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody. Cancer Res. 1993 Sep 15; 53(18):4143-7.Cancer Res1993-09-15T00:00:001993Modulation of in vitro invasion of human glioblastoma cells by urokinase-type plasminogen activator receptor antibody.9178895Mohanam S, Chintala SK, Go Y, Bhattacharya A, Venkaiah B, Boyd D, Gokaslan ZL, Sawaya R, Rao JSOncogeneIn vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor. Oncogene. 1997 Mar 20; 14(11):1351-9.Oncogene1997-03-20T00:00:001997In vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor.D015971Physiology4337080.769985Gene Expression Regulation, EnzymologicD011956Chemicals & Drugs4248610.735517Receptors, Cell SurfaceD014568Chemicals & Drugs691360.950543Urokinase-Type Plasminogen ActivatorD011401Chemicals & Drugs92831040.577776Promoter Regions, GeneticD020780Chemicals & Drugs1993590.869909Matrix Metalloproteinase 9UrologyDepartment of Molecular & Cellular BiologyMolecular & Cellular BiologyBaylor College of MedicineBERTO'MALLEYBERT O'MALLEY0.000000000000000.000000000000002464O'MALLEY, BERTDistinguished Service Professor23350937Kim J, Ebertowski J, Janiga M, Arzola J, Gillespie G, Fountain M, Soderdahl D, Canby-Hagino E, Elsamanoudi S, Gurski J, Davis JW, Parker PA, Boyd DDBJU internationalMany young men with prostate-specific antigen (PSA) screen-detected prostate cancers may be candidates for active surveillance. BJU Int. 2013 May; 111(6):934-40.BJU Int2013-01-25T00:00:002013Many young men with prostate-specific antigen (PSA) screen-detected prostate cancers may be candidates for active surveillance.true1Distinguished Service ProfessorDistinguished Service ProfessorAuthorship 1020227634082896Peng K, Shen YP, Ying YY, Kiaii B, Rodriguez V, Boyd D, Applegate RL, Lubarsky DA, Zhang Z, Xia Z, Feng XM, Yang JP, Liu H, Ji FHBritish journal of anaesthesiaPerioperative dexmedetomidine and 5-year survival in patients undergoing cardiac surgery. Br J Anaesth. 2021 08; 127(2):215-223.Br J Anaesth2021-05-31T00:00:002021Perioperative dexmedetomidine and 5-year survival in patients undergoing cardiac surgery.15031282Wang H, Yang L, Jamaluddin MS, Boyd DDThe Journal of biological chemistryThe Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells. J Biol Chem. 2004 May 21; 279(21):22674-83.J Biol Chem2004-03-18T00:00:002004The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells.15252041Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BBThe Journal of biological chemistryGenetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem. 2004 Sep 17; 279(38):39541-54.J Biol Chem2004-07-13T00:00:002004Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.16261846Nair RR, Wang H, Jamaluddin MS, Fokt I, Priebe W, Boyd DDOncology researchA bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region. Oncol Res. 2005; 15(5):265-79.Oncol Res2005-01-01T00:00:002005A bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region.11900220Aligayer H, Boyd DD, Heiss MM, Abdalla EK, Curley SA, Gallick GECancerActivation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer. 2002 Jan 15; 94(2):344-51.Cancer2002-01-15T00:00:002002Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis.true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professor