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ANNEMIEKE KAVELAARS

TitleProfessor
InstitutionMD Anderson
DepartmentSymptom Research CAO
Address1400 Pressler St
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inyang KE, Sim J, Clark KB, Geron M, Monahan K, Evans C, O'Connell P, Laumet S, Peng B, Ma J, Heijnen CJ, Dantzer R, Scherrer G, Kavelaars A, Bernard M, Aldhamen YA, Folger JK, Bavencoffe A, Laumet G. Upregulation of delta opioid receptor by meningeal interleukin-10 prevents relapsing pain. Brain Behav Immun. 2024 Sep 29; 123:399-410. PMID: 39349285.
      Citations:    Fields:    
    2. Garrity R, Arora N, Haque MA, Weis D, Trinh RT, Neerukonda SV, Kumari S, Cortez I, Ubogu EE, Mahalingam R, Tavares-Ferreira D, Price TJ, Kavelaars A, Heijnen CJ, Shepherd AJ. Fibroblast-derived PI16 sustains inflammatory pain via regulation of CD206+ myeloid cells. Brain Behav Immun. 2023 08; 112:220-234. PMID: 37315702; PMCID: PMC10527931.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Inyang KE, Sim J, Clark KB, Matan G, Monahan K, Evans C, Beng P, Ma JV, Heijnen CJ, Dantzer R, Scherrer G, Kavelaars A, Bernard M, Aldhamen Y, Folger JK, Laumet G. Tonic Meningeal Interleukin-10 Upregulates Delta Opioid Receptor to Prevent Relapse to Pain. bioRxiv. 2023 Jun 09. PMID: 37333074; PMCID: PMC10274865.
      Citations:    
    4. Wang Y, Lopez-Bellido R, Huo X, Kavelaars A, Galko MJ. The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice. Biol Open. 2023 06 15; 12(6). PMID: 37259940; PMCID: PMC10245137.
      Citations:    Fields:    Translation:AnimalsCells
    5. Zamorano M, Alexander JF, Catania D, Dharmaraj S, Kavelaars A, Heijnen CJ. Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice. Immun Ageing. 2023 Jan 25; 20(1):5. PMID: 36698170; PMCID: PMC9874182.
      Citations: 1     
    6. Yap TA, Daver N, Mahendra M, Zhang J, Kamiya-Matsuoka C, Meric-Bernstam F, Kantarjian HM, Ravandi F, Collins ME, Francesco MED, Dumbrava EE, Fu S, Gao S, Gay JP, Gera S, Han J, Hong DS, Jabbour EJ, Ju Z, Karp DD, Lodi A, Molina JR, Baran N, Naing A, Ohanian M, Pant S, Pemmaraju N, Bose P, Piha-Paul SA, Rodon J, Salguero C, Sasaki K, Singh AK, Subbiah V, Tsimberidou AM, Xu QA, Yilmaz M, Zhang Q, Li Y, Bristow CA, Bhattacharjee MB, Tiziani S, Heffernan TP, Vellano CP, Jones P, Heijnen CJ, Kavelaars A, Marszalek JR, Konopleva M. Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials. Nat Med. 2023 01; 29(1):115-126. PMID: 36658425.
      Citations: 28     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    7. Zhang J, Junigan JM, Trinh R, Kavelaars A, Heijnen CJ, Grace PM. HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling. J Neurosci. 2022 10 19; 42(42):7862-7874. PMID: 36096670; PMCID: PMC9617617.
      Citations:    
    8. Lacourt TE, Kavelaars A, Tripathy D, Heijnen CJ. Associations between fatigue and cellular metabolism in breast cancer patients: A longitudinal study. Psychoneuroendocrinology. 2022 10; 144:105866. PMID: 35853380.
      Citations:    Fields:    
    9. Singh SK, Krukowski K, Laumet GO, Weis D, Alexander JF, Heijnen CJ, Kavelaars A. CD8+ T cell-derived IL-13 increases macrophage IL-10 to resolve neuropathic pain. JCI Insight. 2022 03 08; 7(5). PMID: 35260535; PMCID: PMC8983134.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Singh AK, Mahalingam R, Squillace S, Jacobson KA, Tosh DK, Dharmaraj S, Farr SA, Kavelaars A, Salvemini D, Heijnen CJ. Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice. Acta Neuropathol Commun. 2022 01 29; 10(1):11. PMID: 35093182; PMCID: PMC8800287.
      Citations: 1     Fields:    Translation:AnimalsCells
    11. Alexander JF, Mahalingam R, Seua AV, Wu S, Arroyo LD, Schedlowski M, Blanco E, Kavelaars A, Heijnen CJ, H?rbelt T. Targeting the Meningeal Compartment to Resolve Chemobrain and Neuropathy via Nasal Delivery of Functionalized Mitochondria. Adv Healthc Mater. 2022 04; 11(8):e2102153. PMID: 35007407; PMCID: PMC9803615.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. McAlpin BR, Mahalingam R, Singh AK, Dharmaraj S, Chrisikos TT, Boukelmoune N, Kavelaars A, Heijnen CJ. HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity. Theranostics. 2022; 12(2):603-619. PMID: 34976203; PMCID: PMC8692908.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Zhang J, Ma J, Trinh RT, Heijnen CJ, Kavelaars A. An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway. Brain Behav Immun. 2022 02; 100:287-296. PMID: 34915156; PMCID: PMC8766942.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2022 Jan; 195:114860. PMID: 34864607; PMCID: PMC8718107.
      Citations:    Fields:    
    15. Kavelaars A, Heijnen CJ. Immune regulation of pain: Friend and foe. Sci Transl Med. 2021 11 10; 13(619):eabj7152. PMID: 34757809; PMCID: PMC8889025.
      Citations: 2     Fields:    Translation:HumansCells
    16. Ma J, Goodwani S, Acton PJ, Buggia-Prevot V, Kesler SR, Jamal I, Mahant ID, Liu Z, Mseeh F, Roth BL, Chakraborty C, Peng B, Wu Q, Jiang Y, Le K, Soth MJ, Jones P, Kavelaars A, Ray WJ, Heijnen CJ. Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments. Pain. 2021 10 01; 162(10):2599-2612. PMID: 33872235; PMCID: PMC8442742.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    17. Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. Biochem Pharmacol. 2021 10; 192:114688. PMID: 34274354; PMCID: PMC8478865.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    18. Kavelaars A, Heijnen CJ. T Cells as Guardians of Pain Resolution. Trends Mol Med. 2021 04; 27(4):302-313. PMID: 33431239; PMCID: PMC8005447.
      Citations: 6     Fields:    Translation:HumansCells
    19. Alexander JF, Seua AV, Arroyo LD, Ray PR, Wangzhou A, Schedlowski M, Price TJ, Kavelaars A, Heijnen CJ, Hei?-L?ckemann L. Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits. Theranostics. 2021; 11(7):3109-3130. PMID: 33537077; PMCID: PMC7847685.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    20. Boukelmoune N, Laumet G, Tang Y, Ma J, Mahant I, Singh SK, Nijboer C, Benders M, Kavelaars A, Heijnen CJ. Nasal administration of mesenchymal stem cells reverses chemotherapy-induced peripheral neuropathy in mice. Brain Behav Immun. 2021 03; 93:43-54. PMID: 33316379; PMCID: PMC8826497.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    21. Chiang ACA, Seua AV, Singhmar P, Arroyo LD, Mahalingam R, Hu J, Kavelaars A, Heijnen CJ. Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice. Acta Neuropathol Commun. 2020 11 12; 8(1):193. PMID: 33183353; PMCID: PMC7661216.
      Citations: 2     Fields:    Translation:AnimalsCells
    22. Laumet G, Bavencoffe A, Edralin JD, Huo XJ, Walters ET, Dantzer R, Heijnen CJ, Kavelaars A. Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability. Pain. 2020 10; 161(10):2344-2352. PMID: 32427749; PMCID: PMC7962468.
      Citations: 15     Fields:    Translation:AnimalsCells
    23. English K, Shepherd A, Uzor NE, Trinh R, Kavelaars A, Heijnen CJ. Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer. Acta Neuropathol Commun. 2020 03 20; 8(1):36. PMID: 32197663; PMCID: PMC7082981.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Singhmar P, Trinh RTP, Ma J, Huo X, Peng B, Heijnen CJ, Kavelaars A. The fibroblast-derived protein PI16 controls neuropathic pain. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5463-5471. PMID: 32079726; PMCID: PMC7071920.
      Citations: 14     Fields:    Translation:AnimalsCells
    25. Li J, Ma J, Lacagnina MJ, Lorca S, Odem MA, Walters ET, Kavelaars A, Grace PM. Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling. Anesthesiology. 2020 02; 132(2):343-356. PMID: 31939850; PMCID: PMC6993879.
      Citations: 11     Fields:    Translation:AnimalsCells
    26. Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. CD3+ T cells are critical for the resolution of comorbid inflammatory pain and depression-like behavior. Neurobiol Pain. 2020 Jan-Jul; 7:100043. PMID: 32510006; PMCID: PMC7264986.
      Citations: 5     
    27. Willemen HLDM, Prieto P, Heijnen CJ, Kavelaars A, Vila-Bedmar R, Cruces-Sande M, Arcones AC, Moreno-Indias I, D?az-Rodr?guez D, Francisco S, Ja?n RI, Guti?rrez-Repiso C, Bosc? L, Fresno M, Mayor F, Murga C. GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity. Cell Mol Life Sci. 2020 Dec; 77(23):4957-4976. PMID: 31927610; PMCID: PMC11105060.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. Ma J, Trinh RT, Mahant ID, Peng B, Matthias P, Heijnen CJ, Kavelaars A. Cell-specific role of histone deacetylase 6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers. Pain. 2019 12; 160(12):2877-2890. PMID: 31356453; PMCID: PMC6856416.
      Citations: 21     Fields:    Translation:AnimalsCells
    29. Inyang KE, McDougal TA, Ramirez ED, Williams M, Laumet G, Kavelaars A, Heijnen CJ, Burton M, Dussor G, Price TJ. Alleviation of paclitaxel-induced mechanical hypersensitivity and hyperalgesic priming with AMPK activators in male and female mice. Neurobiol Pain. 2019 Aug-Dec; 6:100037. PMID: 31650090; PMCID: PMC6804652.
      Citations: 10     
    30. Laumet G, Ma J, Robison AJ, Kumari S, Heijnen CJ, Kavelaars A. T Cells as an Emerging Target for Chronic Pain Therapy. Front Mol Neurosci. 2019; 12:216. PMID: 31572125; PMCID: PMC6749081.
      Citations: 27     
    31. Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice. Pain. 2019 06; 160(6):1459-1468. PMID: 30720585; PMCID: PMC6527475.
      Citations: 24     Fields:    Translation:AnimalsCells
    32. Chiang ACA, Huo X, Kavelaars A, Heijnen CJ. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain Behav Immun. 2019 07; 79:319-325. PMID: 30953771; PMCID: PMC6591052.
      Citations: 12     Fields:    Translation:Animals
    33. Boukelmoune N, Chiu GS, Kavelaars A, Heijnen CJ. Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin. Acta Neuropathol Commun. 2018 12 12; 6(1):139. PMID: 30541620; PMCID: PMC6292021.
      Citations: 31     Fields:    Translation:AnimalsCells
    34. Huo X, Reyes TM, Heijnen CJ, Kavelaars A. Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice. Sci Rep. 2018 11 27; 8(1):17400. PMID: 30479361; PMCID: PMC6258730.
      Citations: 12     Fields:    Translation:AnimalsCells
    35. Chiu GS, Boukelmoune N, Chiang ACA, Peng B, Rao V, Kingsley C, Liu HL, Kavelaars A, Kesler SR, Heijnen CJ. Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice. Oncotarget. 2018 Oct 30; 9(85):35581-35597. PMID: 30473752; PMCID: PMC6238972.
      Citations: 25     Fields:    
    36. Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ. Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. Acta Neuropathol Commun. 2018 10 01; 6(1):103. PMID: 30270813; PMCID: PMC6166273.
      Citations: 21     Fields:    Translation:AnimalsCells
    37. Lacourt TE, Kavelaars A, Ohanian M, Shah ND, Shelburne SA, Futreal A, Kontoyiannis DP, Heijnen CJ. Patient-reported fatigue prior to treatment is prognostic of survival in patients with acute myeloid leukemia. Oncotarget. 2018 Jul 27; 9(58):31244-31252. PMID: 30131851; PMCID: PMC6101294.
      Citations: 4     Fields:    
    38. Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology. 2018 12; 43(13):2597-2605. PMID: 30054585; PMCID: PMC6224384.
      Citations: 22     Fields:    Translation:AnimalsCells
    39. Price TJ, Basbaum AI, Bresnahan J, Chambers JF, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH, De Koninck Y. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci. 2018 07; 19(7):383-384. PMID: 29765159; PMCID: PMC6237656.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    40. Wang HJ, Gu HX, Eijkelkamp N, Heijnen CJ, Kavelaars A. Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor. Front Pharmacol. 2018; 9:592. PMID: 29922165; PMCID: PMC5996251.
      Citations: 8     
    41. Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A. Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy. Pain. 2018 May; 159(5):884-893. PMID: 29369966; PMCID: PMC5908748.
      Citations: 22     Fields:    Translation:AnimalsCells
    42. Vichaya EG, Laumet G, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R. Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase. Neuropsychopharmacology. 2019 01; 44(2):364-371. PMID: 29760410; PMCID: PMC6300560.
      Citations: 9     Fields:    Translation:Animals
    43. Lacourt TE, Kavelaars A, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ, Galloway-Pe?a JR. Associations of inflammation with symptom burden in patients with acute myeloid leukemia. Psychoneuroendocrinology. 2018 03; 89:203-208. PMID: 29414033.
      Citations: 4     Fields:    Translation:Humans
    44. Ma J, Kavelaars A, Dougherty PM, Heijnen CJ. Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source. Cancer. 2018 06 01; 124(11):2289-2298. PMID: 29461625; PMCID: PMC5991994.
      Citations: 51     Fields:    Translation:HumansCells
    45. Willemen HLDM, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen LJJ, Tromp J, Gonzalez Cano R, Zhou W, Jakobsson ME, Malecki J, Posthuma G, Habib AM, Heijnen CJ, Eijkelkamp N, Falnes P?. Identification of FAM173B as a protein methyltransferase promoting chronic pain. PLoS Biol. 2018 02; 16(2):e2003452. PMID: 29444090; PMCID: PMC5828452.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    46. Boks MP, Rutten BPF, Daskalakis NP, de Nijs L, van Zuiden M, Kavelaars A, Heijnen CJ, Kahn RS, Geuze E, Vermetten E, Vinkers CH, Sch?r RR, Jo?ls M. Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment. Transl Psychiatry. 2017 07 25; 7(7):e1181. PMID: 28742078; PMCID: PMC5538126.
      Citations: 11     Fields:    Translation:HumansCells
    47. Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O'Connor JC, Lee AW, Heijnen CJ, Kavelaars A. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain Behav Immun. 2017 Nov; 66:94-102. PMID: 28709913; PMCID: PMC5650931.
      Citations: 32     Fields:    Translation:AnimalsCells
    48. Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, van Duzer JH, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain. 2017 06; 158(6):1126-1137. PMID: 28267067; PMCID: PMC5435512.
      Citations: 57     Fields:    Translation:Animals
    49. Maj MA, Ma J, Krukowski KN, Kavelaars A, Heijnen CJ. Inhibition of Mitochondrial p53 Accumulation by PFT-? Prevents Cisplatin-Induced Peripheral Neuropathy. Front Mol Neurosci. 2017; 10:108. PMID: 28458631; PMCID: PMC5394177.
      Citations: 32     
    50. Chiu GS, Maj MA, Rizvi S, Dantzer R, Vichaya EG, Laumet G, Kavelaars A, Heijnen CJ. Pifithrin-? Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function. Cancer Res. 2017 02 01; 77(3):742-752. PMID: 27879267; PMCID: PMC5290207.
      Citations: 36     Fields:    Translation:AnimalsCells
    51. Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A. Epac1 interacts with importin ?1 and controls neurite outgrowth independently of cAMP and Rap1. Sci Rep. 2016 11 03; 6:36370. PMID: 27808165; PMCID: PMC5093460.
      Citations: 9     Fields:    Translation:HumansCells
    52. Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci. 2016 10 26; 36(43):11074-11083. PMID: 27798187; PMCID: PMC5098842.
      Citations: 80     Fields:    Translation:AnimalsCells
    53. Eijkelkamp N, Steen-Louws C, Hartgring SA, Willemen HL, Prado J, Lafeber FP, Heijnen CJ, Hack CE, van Roon JA, Kavelaars A. IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain. J Neurosci. 2016 07 13; 36(28):7353-63. PMID: 27413147; PMCID: PMC4945660.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    54. Zhou W, Kavelaars A, Heijnen CJ. Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice. PLoS One. 2016; 11(3):e0151890. PMID: 27018597; PMCID: PMC4809545.
      Citations: 56     Fields:    Translation:AnimalsCells
    55. Zhang H, Li Y, de Carvalho-Barbosa M, Kavelaars A, Heijnen CJ, Albrecht PJ, Dougherty PM. Dorsal Root Ganglion Infiltration by Macrophages Contributes to?Paclitaxel Chemotherapy-Induced Peripheral Neuropathy. J Pain. 2016 07; 17(7):775-86. PMID: 26979998; PMCID: PMC4939513.
      Citations: 107     Fields:    Translation:AnimalsCells
    56. Singhmar P, Huo X, Eijkelkamp N, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Heijnen CJ, Kavelaars A, Berciano SR, Mayor F, Murga C. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3036-41. PMID: 26929333; PMCID: PMC4801297.
      Citations: 56     Fields:    Translation:AnimalsCells
    57. Krukowski K, Nijboer CH, Huo X, Kavelaars A, Heijnen CJ. Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-?. Pain. 2015 Nov; 156(11):2184-2192. PMID: 26473292; PMCID: PMC4900465.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    58. Vichaya EG, Molkentine JM, Vermeer DW, Walker AK, Feng R, Holder G, Luu K, Mason RM, Saligan L, Heijnen CJ, Kavelaars A, Mason KA, Lee JH, Dantzer R. Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression. Behav Brain Res. 2016 Jan 15; 297:241-50. PMID: 26475509; PMCID: PMC4679574.
      Citations: 12     Fields:    Translation:AnimalsCells
    59. Donega V, Nijboer CH, van Velthoven CT, Youssef SA, de Bruin A, van Bel F, Kavelaars A, Heijnen CJ. Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse. Pediatr Res. 2015 Nov; 78(5):520-6. PMID: 26270577; PMCID: PMC4635434.
      Citations: 37     Fields:    Translation:AnimalsCells
    60. Willemen HL, Heijnen CJ, Kavelaars A, Vila-Bedmar R, Cruces-Sande M, Lucas E, Mayor F, Murga C. Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2. Sci Signal. 2015 Jul 21; 8(386):ra73. PMID: 26198359; PMCID: PMC4586018.
      Citations: 25     Fields:    Translation:HumansAnimals
    61. Vichaya EG, Chiu GS, Krukowski K, Lacourt TE, Kavelaars A, Dantzer R, Heijnen CJ, Walker AK. Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci. 2015; 9:131. PMID: 25954147; PMCID: PMC4404721.
      Citations: 66     
    62. Zhou W, Dantzer R, Budac DP, Walker AK, Mao-Ying QL, Lee AW, Heijnen CJ, Kavelaars A. Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun. 2015 May; 46:147-53. PMID: 25637485; PMCID: PMC4414738.
      Citations: 21     Fields:    Translation:Animals
    63. Donega V, Nijboer CH, Braccioli L, Slaper-Cortenbach I, Kavelaars A, van Bel F, Heijnen CJ. Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions. PLoS One. 2014; 9(11):e112339. PMID: 25396420; PMCID: PMC4232359.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    64. Ter Wolbeek M, Kavelaars A, de Vries WB, Tersteeg-Kamperman M, Veen S, van Weissenbruch M, Baerts W, Liem KD, van Bel F, Heijnen CJ, Kornelisse RF. Neonatal glucocorticoid treatment: long-term effects on the hypothalamus-pituitary-adrenal axis, immune system, and problem behavior in 14-17 year old adolescents. Brain Behav Immun. 2015 Mar; 45:128-38. PMID: 25449580.
      Citations: 9     Fields:    Translation:Humans
    65. van Zuiden M, Kavelaars A, Vermetten E, Olff M, Geuze E, Heijnen C. Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return from military deployment. Psychoneuroendocrinology. 2015 Jan; 51:513-24. PMID: 25277845.
      Citations: 11     Fields:    Translation:HumansCells
    66. Smid GE, van Zuiden M, Geuze E, Kavelaars A, Heijnen CJ, Vermetten E. Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers. Psychoneuroendocrinology. 2015 Jan; 51:534-46. PMID: 25106657.
      Citations: 14     Fields:    Translation:Humans
    67. Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ. The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model. PLoS One. 2014; 9(6):e100701. PMID: 24955774; PMCID: PMC4067328.
      Citations: 74     Fields:    Translation:AnimalsCells
    68. Donega V, Nijboer CH, van Tilborg G, Dijkhuizen RM, Kavelaars A, Heijnen CJ. Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury. Exp Neurol. 2014 Nov; 261:53-64. PMID: 24945601.
      Citations: 62     Fields:    Translation:AnimalsCells
    69. Willemen HL, Eijkelkamp N, Garza Carbajal A, Wang H, Mack M, Zijlstra J, Heijnen CJ, Kavelaars A. Monocytes/Macrophages control resolution of transient inflammatory pain. J Pain. 2014 May; 15(5):496-506. PMID: 24793056; PMCID: PMC4075647.
      Citations: 50     Fields:    Translation:AnimalsCells
    70. Willemen HL, Lucas E, Ramos P, Heijnen C, Mayor F, Kavelaars A, Murga C, Campos PM, Morreale A, Gil-Redondo R, Agut J, Gonz?lez FV. A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia. Biochem J. 2014 May 01; 459(3):427-39. PMID: 24517375; PMCID: PMC3998648.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    71. Brouwers C, Versteeg H, Meine M, Heijnen CJ, Kavelaars AM, Pedersen SS, Mommersteeg PM. Association between brain natriuretic peptide, markers of inflammation and the objective and subjective response to cardiac resynchronization therapy. Brain Behav Immun. 2014 Aug; 40:211-8. PMID: 24704567.
      Citations: 4     Fields:    Translation:Humans
    72. Kooijman E, Nijboer CH, van Velthoven CT, Kavelaars A, Kesecioglu J, Heijnen CJ. The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies. J Neuroinflammation. 2014 Jan 03; 11:2. PMID: 24386932; PMCID: PMC3892045.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    73. Walker AK, Kavelaars A, Heijnen CJ, Dantzer R. Neuroinflammation and comorbidity of pain and depression. Pharmacol Rev. 2014; 66(1):80-101. PMID: 24335193; PMCID: PMC3880465.
      Citations: 131     Fields:    Translation:HumansAnimals
    74. Wang H, Heijnen CJ, van Velthoven CT, Willemen HL, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, Kavelaars A. Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. J Clin Invest. 2013 Dec; 123(12):5023-34. PMID: 24231349; PMCID: PMC3859388.
      Citations: 50     Fields:    Translation:AnimalsCells
    75. Dantzer R, Heijnen CJ, Kavelaars A, Laye S, Capuron L. The neuroimmune basis of fatigue. Trends Neurosci. 2014 Jan; 37(1):39-46. PMID: 24239063; PMCID: PMC3889707.
      Citations: 97     Fields:    Translation:HumansAnimals
    76. van Velthoven CT, Braccioli L, Willemen HL, Kavelaars A, Heijnen CJ. Therapeutic potential of genetically modified mesenchymal stem cells after neonatal hypoxic-ischemic brain damage. Mol Ther. 2014 Mar; 22(3):645-654. PMID: 24172866; PMCID: PMC3944339.
      Citations: 20     Fields:    Translation:AnimalsCells
    77. Nessler J, Gudi V, Hoffmann A, Salinas Tejedor L, Prajeeth CK, Kavelaars A, Heijnen CJ, van Velthoven C, Hansmann F, Skripuletz T, Stangel M, B?nardais K, Jan?en S, Baumg?rtner W. Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination. PLoS One. 2013; 8(7):e69795. PMID: 23922802; PMCID: PMC3724887.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    78. Bonestroo HJ, Nijboer CH, van Velthoven CT, Kavelaars A, Hack CE, van Bel F, Heijnen CJ. Cerebral and hepatic inflammatory response after neonatal hypoxia-ischemia in newborn rats. Dev Neurosci. 2013; 35(2-3):197-211. PMID: 23689428.
      Citations: 29     Fields:    Translation:Animals
    79. van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM. Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. Stroke. 2013 May; 44(5):1426-32. PMID: 23539530; PMCID: PMC3694433.
      Citations: 86     Fields:    Translation:AnimalsCells
    80. Nijboer C, Kaindl AM, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P, Degos V, Peineau S, Sigaut S, Favrais G. G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Ann Neurol. 2013 May; 73(5):667-78. PMID: 23494575; PMCID: PMC3837433.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    81. Hegeman MA, Hennus MP, Cobelens PM, Kavelaars A, Jansen NJ, Schultz MJ, van Vught AJ, Heijnen CJ. Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury. PLoS One. 2013; 8(2):e57374. PMID: 23451215; PMCID: PMC3581459.
      Citations: 15     Fields:    Translation:Animals
    82. Donega V, van Velthoven CT, Nijboer CH, Kavelaars A, Heijnen CJ. The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment. J Cereb Blood Flow Metab. 2013 May; 33(5):625-34. PMID: 23403379; PMCID: PMC3652688.
      Citations: 24     Fields:    Translation:HumansAnimals
    83. Nijboer CH, Bonestroo HJ, Zijlstra J, Kavelaars A, Heijnen CJ. Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage. Neurobiol Dis. 2013 Jun; 54:432-44. PMID: 23376684.
      Citations: 32     Fields:    Translation:AnimalsCells
    84. Nijboer CH, Heijnen CJ, Degos V, Willemen HL, Gressens P, Kavelaars A. Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage. Neurobiol Dis. 2013 Jun; 54:206-15. PMID: 23313319; PMCID: PMC3628971.
      Citations: 6     Fields:    Translation:AnimalsCells
    85. Donega V, van Velthoven CT, Nijboer CH, van Bel F, Kas MJ, Kavelaars A, Heijnen CJ. Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement. PLoS One. 2013; 8(1):e51253. PMID: 23300948; PMCID: PMC3536775.
      Citations: 68     Fields:    Translation:AnimalsCells
    86. ter Wolbeek M, de Sonneville LM, de Vries WB, Kavelaars A, Veen S, van Weissenbruch M, Baerts W, Liem KD, van Bel F, Heijnen CJ, Kornelisse RF. Early life intervention with glucocorticoids has negative effects on motor development and neuropsychological function in 14-17 year-old adolescents. Psychoneuroendocrinology. 2013 Jul; 38(7):975-86. PMID: 23107421.
      Citations: 8     Fields:    Translation:Humans
    87. Rijsdijk M, van Wijck AJ, Meulenhoff PC, Kavelaars A, van der Tweel I, Kalkman CJ. No beneficial effect of intrathecal methylprednisolone acetate in postherpetic neuralgia patients. Eur J Pain. 2013 May; 17(5):714-23. PMID: 23059790.
      Citations: 9     Fields:    Translation:Humans
    88. Otten JJ, de Jager SC, Kavelaars A, Seijkens T, Bot I, Wijnands E, Beckers L, Westra MM, Bot M, Busch M, Bermudez B, van Berkel TJ, Heijnen CJ, Biessen EA. Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice. FASEB J. 2013 Jan; 27(1):265-76. PMID: 23047899; PMCID: PMC3528319.
      Citations: 12     Fields:    Translation:Animals
    89. Degos V, Gouadon E, Chhor V, Loron G, Le Charpentier T, Josserand J, Ali C, Vivien D, Collingridge GL, Lombet A, Issa L, Loeffler JP, Kavelaars A, Verney C, Mantz J, Gressens P, Kaindl AM, Peineau S, Rene F. Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann Neurol. 2012 Oct; 72(4):536-49. PMID: 23109148.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    90. Peters MJ, Broer L, Willemen HL, Eiriksdottir G, Hocking LJ, Holliday KL, Horan MA, Meulenbelt I, Neogi T, Popham M, Schmidt CO, Soni A, Valdes AM, Amin N, Dennison EM, Eijkelkamp N, Harris TB, Hart DJ, Hofman A, Huygen FJ, Jameson KA, Jones GT, Launer LJ, Kerkhof HJ, de Kruijf M, McBeth J, Kloppenburg M, Ollier WE, Oostra B, Payton A, Rivadeneira F, Smith BH, Smith AV, Stolk L, Teumer A, Thomson W, Wang K, van Wingerden SH, Arden NK, Cooper C, Felson D, Gudnason V, Macfarlane GJ, Pendleton N, Slagboom PE, Spector TD, Kavelaars A, van Duijn CM, Williams FM, van Meurs JB, Uitterlinden AG, V?lzke H. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. Ann Rheum Dis. 2013 Mar; 72(3):427-36. PMID: 22956598; PMCID: PMC3691951.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    91. van Zuiden M, Kavelaars A, Geuze E, Olff M, Heijnen CJ. Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions. Brain Behav Immun. 2013 May; 30:12-21. PMID: 22981834.
      Citations: 43     Fields:    Translation:HumansCells
    92. van Zuiden M, Kavelaars A, Amarouchi K, Maas M, Vermetten E, Geuze E, Heijnen CJ. IL-1? reactivity and the development of severe fatigue after military deployment: a longitudinal study. J Neuroinflammation. 2012 Aug 21; 9:205. PMID: 22908999; PMCID: PMC3485092.
      Citations: 4     Fields:    Translation:HumansCells
    93. Weimar CH, Kavelaars A, Brosens JJ, Gellersen B, de Vreeden-Elbertse JM, Heijnen CJ, Macklon NS. Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos. PLoS One. 2012; 7(7):e41424. PMID: 22848492; PMCID: PMC3405140.
      Citations: 41     Fields:    Translation:HumansCellsCTClinical Trials
    94. Willemen HL, Huo XJ, Mao-Ying QL, Zijlstra J, Heijnen CJ, Kavelaars A. MicroRNA-124 as a novel treatment for persistent hyperalgesia. J Neuroinflammation. 2012 Jun 25; 9:143. PMID: 22731384; PMCID: PMC3418202.
      Citations: 70     Fields:    Translation:AnimalsCells
    95. van Velthoven CT, van de Looij Y, Kavelaars A, Zijlstra J, van Bel F, Huppi PS, Heijnen CJ, Sizonenko S. Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice. Ann Neurol. 2012 Jun; 71(6):785-96. PMID: 22718545.
      Citations: 34     Fields:    Translation:AnimalsCells
    96. Eijkelkamp N, Heijnen CJ, Carbajal AG, Willemen HL, Wang H, Minett MS, Wood JN, Schedlowski M, Dantzer R, Kelley KW, Kavelaars A. G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling. Mol Med. 2012 May 09; 18:556-64. PMID: 22331028; PMCID: PMC3388142.
      Citations: 15     Fields:    Translation:AnimalsCells
    97. van Zuiden M, Heijnen CJ, Maas M, Amarouchi K, Vermetten E, Geuze E, Kavelaars A. Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: A prospective study. Psychoneuroendocrinology. 2012 Nov; 37(11):1822-36. PMID: 22503138.
      Citations: 29     Fields:    Translation:HumansCells
    98. Geuze E, van Wingen GA, van Zuiden M, Rademaker AR, Vermetten E, Kavelaars A, Heijnen CJ, Fern?ndez G. Glucocorticoid receptor number predicts increase in amygdala activity after severe stress. Psychoneuroendocrinology. 2012 Nov; 37(11):1837-44. PMID: 22503140.
      Citations: 8     Fields:    Translation:HumansCells
    99. van Meer MP, Otte WM, van der Marel K, Nijboer CH, Kavelaars A, van der Sprenkel JW, Viergever MA, Dijkhuizen RM. Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity. J Neurosci. 2012 Mar 28; 32(13):4495-507. PMID: 22457497; PMCID: PMC6622065.
      Citations: 97     Fields:    Translation:AnimalsCells
    100. van Velthoven CT, Kavelaars A, Heijnen CJ. Mesenchymal stem cells as a treatment for neonatal ischemic brain damage. Pediatr Res. 2012 Apr; 71(4 Pt 2):474-81. PMID: 22430383.
      Citations: 62     Fields:    Translation:HumansCells
    101. van Zuiden M, Heijnen CJ, van de Schoot R, Amarouchi K, Maas M, Vermetten E, Geuze E, Kavelaars A. Cytokine production by leukocytes of military personnel with depressive symptoms after deployment to a combat-zone: a prospective, longitudinal study. PLoS One. 2011; 6(12):e29142. PMID: 22195009; PMCID: PMC3237604.
      Citations: 15     Fields:    Translation:HumansCells
    102. van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Amarouchi K, Kavelaars A, Heijnen CJ. Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study. Biol Psychiatry. 2012 Feb 15; 71(4):309-16. PMID: 22137507.
      Citations: 72     Fields:    Translation:Humans
    103. Kavelaars A, Dalous J, Mani S, El Ghouzzi V, Heijnen C, Baud O, Gressens P, Titomanlio L. Stem cell therapy for neonatal brain injury: perspectives and challenges. Ann Neurol. 2011 Nov; 70(5):698-712. PMID: 22162055.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    104. Blok CA, Krediet TG, Kavelaars A, Koopman-Esseboom C, Vreman HJ, Van Bel F. Early end-tidal carbon monoxide levels and neurodevelopmental outcome at 3 years 6 months of age in preterm infants. Dev Med Child Neurol. 2011 Dec; 53(12):1113-8. PMID: 21933176; PMCID: PMC3220782.
      Citations: 6     Fields:    Translation:Humans
    105. Brekken C, Kavelaars A, Pedersen TB, Heijnen C, Skranes J, Brubakk AM, Wider?e M, Goa PE. Longitudinal manganese-enhanced magnetic resonance imaging of delayed brain damage after hypoxic-ischemic injury in the neonatal rat. Neonatology. 2011; 100(4):363-72. PMID: 21791927.
      Citations: 9     Fields:    Translation:AnimalsCells
    106. van Velthoven CT, Heijnen CJ, van Bel F, Kavelaars A. Osteopontin enhances endogenous repair after neonatal hypoxic-ischemic brain injury. Stroke. 2011 Aug; 42(8):2294-301. PMID: 21700938.
      Citations: 35     Fields:    Translation:AnimalsCells
    107. Nijboer CH, Heijnen CJ, van der Kooij MA, Zijlstra J, van Velthoven CT, Culmsee C, van Bel F, Hagberg H, Kavelaars A. Targeting the p53 pathway to protect the neonatal ischemic brain. Ann Neurol. 2011 Aug; 70(2):255-64. PMID: 21674585.
      Citations: 47     Fields:    Translation:AnimalsCells
    108. Korenromp IH, Grutters JC, van den Bosch JM, Zanen P, Kavelaars A, Heijnen CJ. Reduced Th2 cytokine production by sarcoidosis patients in clinical remission with chronic fatigue. Brain Behav Immun. 2011 Oct; 25(7):1498-502. PMID: 21693184.
      Citations: 7     Fields:    Translation:HumansCells
    109. Mommersteeg PM, Denollet J, Kavelaars A, Geuze E, Vermetten E, Heijnen CJ. Type D personality, temperament, and mental health in military personnel awaiting deployment. Int J Behav Med. 2011 Jun; 18(2):131-8. PMID: 20473600; PMCID: PMC3088830.
      Citations: 4     Fields:    Translation:Humans
    110. ter Wolbeek M, van Doornen LJ, Kavelaars A, Tersteeg-Kamperman MD, Heijnen CJ. Fatigue, depressive symptoms, and anxiety from adolescence up to young adulthood: a longitudinal study. Brain Behav Immun. 2011 Aug; 25(6):1249-55. PMID: 21549830.
      Citations: 13     Fields:    Translation:Humans
    111. Wang H, Heijnen CJ, Eijkelkamp N, Carbajal AG, Schedlowski M, Kelley KW, Dantzer R, Kavelaars A. GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia. Pain. 2011 Jul; 152(7):1649-1658. PMID: 21514055.
      Citations: 26     Fields:    Translation:AnimalsCells
    112. Kavelaars A, Eijkelkamp N, Willemen HL, Wang H, Carbajal AG, Heijnen CJ. Microglial GRK2: a novel regulator of transition from acute to chronic pain. Brain Behav Immun. 2011 Aug; 25(6):1055-60. PMID: 21473908.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    113. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain. Brain Behav Immun. 2011 Oct; 25(7):1342-8. PMID: 21473911.
      Citations: 45     Fields:    Translation:AnimalsCells
    114. de Jager SC, Bot I, Koenen RR, Bot M, Kavelaars A, de Waard V, Heijnen CJ, Muriana FJ, Weber C, van Berkel TJ, Kuiper J, Lee SJ, Abia R, Biessen EA, Berm?dez B. Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. J Exp Med. 2011 Feb 14; 208(2):217-25. PMID: 21242297; PMCID: PMC3039852.
      Citations: 74     Fields:    Translation:AnimalsCells
    115. van Zuiden M, Kavelaars A, Rademaker AR, Vermetten E, Heijnen CJ, Geuze E. A prospective study on personality and the cortisol awakening response to predict posttraumatic stress symptoms in response to military deployment. J Psychiatr Res. 2011 Jun; 45(6):713-9. PMID: 21185572.
      Citations: 11     Fields:    Translation:Humans
    116. Hegeman MA, Hennus MP, van Meurs M, Cobelens PM, Kavelaars A, Jansen NJ, Schultz MJ, van Vught AJ, Molema G, Heijnen CJ. Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury. PLoS One. 2010 Dec 14; 5(12):e15653. PMID: 21179479; PMCID: PMC3001877.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    117. Fan X, Kavelaars A, Heijnen CJ, Groenendaal F, van Bel F. Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. Curr Neuropharmacol. 2010 Dec; 8(4):324-34. PMID: 21629441; PMCID: PMC3080590.
      Citations: 23     Fields:    
    118. van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Heijnen CJ, Kavelaars A. Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment. Am J Psychiatry. 2011 Jan; 168(1):89-96. PMID: 21078706.
      Citations: 70     Fields:    Translation:Humans
    119. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage. Pediatr Res. 2010 Nov; 68(5):419-22. PMID: 20639794.
      Citations: 71     Fields:    Translation:AnimalsCells
    120. Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ, Kavelaars A. Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci. 2010 Sep 22; 30(38):12806-15. PMID: 20861385; PMCID: PMC6633564.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    121. Fu X, Zunich SM, O'Connor JC, Kavelaars A, Dantzer R, Kelley KW. Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures. J Neuroinflammation. 2010 Aug 02; 7:43. PMID: 20678226; PMCID: PMC2921406.
      Citations: 55     Fields:    Translation:AnimalsCells
    122. Riether C, Kavelaars A, Wirth T, Doenlen R, Willemen H, Heijnen CJ, Schedlowski M, Engler H, Pacheco-L?pez G. Stimulation of ?2-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction. Brain Behav Immun. 2011 Jan; 25(1):59-66. PMID: 20674738.
      Citations: 16     Fields:    Translation:AnimalsCells
    123. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. J Neurosci. 2010 Jul 14; 30(28):9603-11. PMID: 20631189; PMCID: PMC6632441.
      Citations: 73     Fields:    Translation:AnimalsCells
    124. Willemen HLDM, Eijkelkamp N, Wang H, Dantzer R, Dorn GW, Kelley KW, Heijnen CJ, Kavelaars A. Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain. 2010 Sep; 150(3):550-560. PMID: 20609517; PMCID: PMC3099597.
      Citations: 54     Fields:    Translation:AnimalsCells
    125. van Venrooij JA, Fluitman SB, Lijmer JG, Kavelaars A, Heijnen CJ, Westenberg HG, Gispen-de Wied CC, Kahn RS. Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis. Schizophr Bull. 2012 Mar; 38(2):272-9. PMID: 20558533; PMCID: PMC3283141.
      Citations: 26     Fields:    Translation:HumansCells
    126. Teklenburg G, Salker M, Molokhia M, Lavery S, Trew G, Aojanepong T, Mardon HJ, Lokugamage AU, Rai R, Landles C, Roelen BA, Quenby S, Kuijk EW, Kavelaars A, Heijnen CJ, Regan L, Brosens JJ, Macklon NS. Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One. 2010 Apr 21; 5(4):e10258. PMID: 20422011; PMCID: PMC2858159.
      Citations: 81     Fields:    Translation:HumansCells
    127. Salker M, Teklenburg G, Molokhia M, Lavery S, Trew G, Aojanepong T, Mardon HJ, Lokugamage AU, Rai R, Landles C, Roelen BA, Quenby S, Kuijk EW, Kavelaars A, Heijnen CJ, Regan L, Macklon NS, Brosens JJ. Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One. 2010 Apr 21; 5(4):e10287. PMID: 20422017; PMCID: PMC2858209.
      Citations: 111     Fields:    Translation:HumansCells
    128. Boomsma CM, Kavelaars A, Bozkurt N, Eijkemans MJ, Fauser BC, Heijnen CJ, Macklon NS. Is bacterial vaginosis associated with a pro-inflammatory cytokine profile in endometrial secretions of women undergoing IVF? Reprod Biomed Online. 2010 Jul; 21(1):133-41. PMID: 20580898.
      Citations: 2     Fields:    Translation:Humans
    129. Eijkelkamp N, Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, Dorn GW, Wood JN, Kavelaars A. GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci. 2010 Feb 10; 30(6):2138-49. PMID: 20147541; PMCID: PMC3129713.
      Citations: 55     Fields:    Translation:AnimalsCells
    130. Heijnen CJ, Kavelaars A. Neuro-immune, behavioral and molecular aspects of brain damage. Brain Behav Immun. 2010 Jul; 24(5):705-7. PMID: 20138140.
      Citations: 1     Fields:    Translation:HumansAnimals
    131. van der Kooij MA, Nijboer CH, Ohl F, Groenendaal F, Heijnen CJ, van Bel F, Kavelaars A. NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats. Neurobiol Dis. 2010 May; 38(2):266-72. PMID: 20132887.
      Citations: 20     Fields:    Translation:AnimalsCells
    132. Boomsma CM, Kavelaars A, Eijkemans MJ, Fauser BC, Heijnen CJ, Macklon NS. Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo. Fertil Steril. 2010 Oct; 94(5):1764-8. PMID: 20004388.
      Citations: 23     Fields:    Translation:Humans
    133. Nijboer CH, Heijnen CJ, Willemen HL, Groenendaal F, Dorn GW, van Bel F, Kavelaars A. Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice. Brain Behav Immun. 2010 Mar; 24(3):420-6. PMID: 19932746; PMCID: PMC3099598.
      Citations: 20     Fields:    Translation:AnimalsCells
    134. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain Behav Immun. 2010 Mar; 24(3):387-93. PMID: 19883750.
      Citations: 85     Fields:    Translation:AnimalsCells
    135. Nijboer CH, van der Kooij MA, van Bel F, Ohl F, Heijnen CJ, Kavelaars A. Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury. Brain Behav Immun. 2010 Jul; 24(5):812-21. PMID: 19766183.
      Citations: 44     Fields:    Translation:AnimalsCells
    136. van der Kooij MA, Ohl F, Arndt SS, Kavelaars A, van Bel F, Heijnen CJ. Mild neonatal hypoxia-ischemia induces long-term motor- and cognitive impairments in mice. Brain Behav Immun. 2010 Jul; 24(5):850-6. PMID: 19748566.
      Citations: 17     Fields:    Translation:Animals
    137. van Zuiden M, Geuze E, Maas M, Vermetten E, Heijnen CJ, Kavelaars A. Deployment-related severe fatigue with depressive symptoms is associated with increased glucocorticoid binding to peripheral blood mononuclear cells. Brain Behav Immun. 2009 Nov; 23(8):1132-9. PMID: 19635550.
      Citations: 7     Fields:    Translation:HumansCells
    138. Nijboer CH, Heijnen CJ, Groenendaal F, van Bel F, Kavelaars A. Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia. Stroke. 2009 Oct; 40(10):3362-8. PMID: 19628795.
      Citations: 24     Fields:    Translation:AnimalsCells
    139. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes. Brain Res Rev. 2009 Jun; 61(1):1-13. PMID: 19348860.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    140. van Putte BP, Cobelens PM, van der Kaaij N, Lachmann B, Kavelaars A, Heijnen CJ, Kesecioglu J. Exogenous surfactant attenuation of ischemia-reperfusion injury in the lung through alteration of inflammatory and apoptotic factors. J Thorac Cardiovasc Surg. 2009 Apr; 137(4):824-8. PMID: 19327503.
      Citations: 6     Fields:    Translation:Animals
    141. Boomsma CM, Kavelaars A, Eijkemans MJ, Lentjes EG, Fauser BC, Heijnen CJ, Macklon NS. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod. 2009 Jun; 24(6):1427-35. PMID: 19228761.
      Citations: 43     Fields:    Translation:HumansCTClinical Trials
    142. Boomsma CM, Kavelaars A, Eijkemans MJ, Amarouchi K, Teklenburg G, Gutknecht D, Fauser BJ, Heijnen CJ, Macklon NS. Cytokine profiling in endometrial secretions: a non-invasive window on endometrial receptivity. Reprod Biomed Online. 2009 Jan; 18(1):85-94. PMID: 19146774.
      Citations: 21     Fields:    Translation:Humans
    143. Pedersen TB, Kavelaars A, Heijnen C, Skranes J, Brubakk AM, Brekken C, Wider?e M, Olsen ?, Goa PE. Manganese-enhanced magnetic resonance imaging of hypoxic-ischemic brain injury in the neonatal rat. Neuroimage. 2009 Apr 15; 45(3):880-90. PMID: 19138750.
      Citations: 21     Fields:    Translation:AnimalsCells
    144. Riether C, Doenlen R, Engler H, Niemi MB, Engler A, Kavelaars A, Heijnen CJ, Schedlowski M, Pacheco-L?pez G. Calcineurin inhibition in splenocytes induced by pavlovian conditioning. FASEB J. 2009 Apr; 23(4):1161-7. PMID: 19103649.
      Citations: 10     Fields:    Translation:AnimalsCells
    145. van der Kooij MA, Groenendaal F, Kavelaars A, Heijnen CJ, van Bel F. Combination of deferoxamine and erythropoietin: therapy for hypoxia-ischemia-induced brain injury in the neonatal rat? Neurosci Lett. 2009 Feb 20; 451(2):109-13. PMID: 19103262.
      Citations: 16     Fields:    Translation:AnimalsCells
    146. Karemaker R, Karemaker JM, Kavelaars A, Tersteeg-Kamperman M, Baerts W, Veen S, Samsom JF, van Bel F, Heijnen CJ. Effects of neonatal dexamethasone treatment on the cardiovascular stress response of children at school age. Pediatrics. 2008 Nov; 122(5):978-87. PMID: 18977976.
      Citations: 7     Fields:    Translation:Humans
    147. Eijkelkamp N, Heijnen CJ, Elsenbruch S, Holtmann G, Schedlowski M, Kavelaars A. G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia. Brain Behav Immun. 2009 Jan; 23(1):18-26. PMID: 18687398.
      Citations: 10     Fields:    Translation:AnimalsCells
    148. Mommersteeg PM, Vermetten E, Kavelaars A, Geuze E, Heijnen CJ. Hostility is related to clusters of T-cell cytokines and chemokines in healthy men. Psychoneuroendocrinology. 2008 Sep; 33(8):1041-50. PMID: 18640786.
      Citations: 17     Fields:    Translation:HumansCells
    149. Cobelens PM, van Putte BP, Kavelaars A, Heijnen CJ, Kesecioglu J. Inflammatory consequences of lung ischemia-reperfusion injury and low-pressure ventilation. J Surg Res. 2009 May 15; 153(2):295-301. PMID: 18952232.
      Citations: 14     Fields:    Translation:Animals
    150. van der Kooij MA, Groenendaal F, Kavelaars A, Heijnen CJ, van Bel F. Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia. Brain Res Rev. 2008 Nov; 59(1):22-33. PMID: 18514916.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    151. Nijboer CH, Heijnen CJ, Groenendaal F, May MJ, van Bel F, Kavelaars A. A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage. Stroke. 2008 Sep; 39(9):2578-86. PMID: 18420947.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    152. Nijboer CH, Heijnen CJ, Groenendaal F, May MJ, van Bel F, Kavelaars A. Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines. Stroke. 2008 Jul; 39(7):2129-37. PMID: 18420952.
      Citations: 54     Fields:    Translation:AnimalsCells
    153. Karemaker R, Kavelaars A, ter Wolbeek M, Tersteeg-Kamperman M, Baerts W, Veen S, Samsom JF, Visser GH, van Bel F, Heijnen CJ. Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age. Pediatrics. 2008 Apr; 121(4):e870-8. PMID: 18381516.
      Citations: 22     Fields:    Translation:Humans
    154. Ribas C, Aymerich I, Eijkelkamp N, Barreiro O, Heijnen CJ, Kavelaars A, Mayor F, Penela P, S?nchez-Madrid F. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008 Apr 23; 27(8):1206-18. PMID: 18369319; PMCID: PMC2367399.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    155. Nijboer CH, Kavelaars A, Vroon A, Groenendaal F, van Bel F, Heijnen CJ. Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage. J Neurosci. 2008 Mar 26; 28(13):3324-32. PMID: 18367599; PMCID: PMC6670601.
      Citations: 18     Fields:    Translation:AnimalsCells
    156. ter Wolbeek M, van Doornen LJ, Kavelaars A, Heijnen CJ. Predictors of persistent and new-onset fatigue in adolescent girls. Pediatrics. 2008 Mar; 121(3):e449-57. PMID: 18310166.
      Citations: 13     Fields:    Translation:Humans
    157. ter Wolbeek M, van Doornen LJ, Schedlowski M, Janssen OE, Kavelaars A, Heijnen CJ. Glucocorticoid sensitivity of immune cells in severely fatigued adolescent girls: a longitudinal study. Psychoneuroendocrinology. 2008 Apr; 33(3):375-85. PMID: 18242001.
      Citations: 3     Fields:    Translation:HumansCells
    158. Mommersteeg PM, Heijnen CJ, Kavelaars A, van Doornen LJ. The HPA-axis and immune function in burnout. Prog Brain Res. 2008; 167:281-5. PMID: 18037026.
      Citations: 3     Fields:    Translation:Humans
    159. van Runnard Heimel PJ, Kavelaars A, Heijnen CJ, Peters WH, Huisjes AJ, Franx A, Bruinse HW. HELLP syndrome is associated with an increased inflammatory response, which may be inhibited by administration of prednisolone. Hypertens Pregnancy. 2008; 27(3):253-65. PMID: 18696354.
      Citations: 11     Fields:    Translation:Humans
    160. Kleibeuker W, Jurado-Pueyo M, Murga C, Eijkelkamp N, Mayor F, Heijnen CJ, Kavelaars A. Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium. J Neurochem. 2008 Feb; 104(4):979-92. PMID: 17971124.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    161. Langhorst J, Cobelens PM, Kavelaars A, Heijnen CJ, Benson S, Rifaie N, Dobos GJ, Schedlowski M, Elsenbruch S. Stress-related peripheral neuroendocrine-immune interactions in women with ulcerative colitis. Psychoneuroendocrinology. 2007 Sep-Nov; 32(8-10):1086-96. PMID: 17933470.
      Citations: 8     Fields:    Translation:HumansCells
    162. Kleibeuker W, Gabay E, Kavelaars A, Zijlstra J, Wolf G, Ziv N, Yirmiya R, Shavit Y, Tal M, Heijnen CJ. IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2. Brain Behav Immun. 2008 Feb; 22(2):200-8. PMID: 17869478.
      Citations: 30     Fields:    Translation:AnimalsCells
    163. Eijkelkamp N, Kavelaars A, Elsenbruch S, Schedlowski M, Holtmann G, Heijnen CJ. Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior. Am J Physiol Gastrointest Liver Physiol. 2007 Oct; 293(4):G749-57. PMID: 17656446.
      Citations: 33     Fields:    Translation:Animals
    164. Houtveen JH, Kavelaars A, Heijnen CJ, van Doornen LJ. Heterogeneous medically unexplained symptoms and immune function. Brain Behav Immun. 2007 Nov; 21(8):1075-82. PMID: 17553664.
      Citations: 3     Fields:    Translation:HumansCells
    165. ter Wolbeek M, van Doornen LJ, Kavelaars A, van de Putte EM, Schedlowski M, Heijnen CJ. Longitudinal analysis of pro- and anti-inflammatory cytokine production in severely fatigued adolescents. Brain Behav Immun. 2007 Nov; 21(8):1063-74. PMID: 17544255.
      Citations: 22     Fields:    Translation:HumansCells
    166. Lombardi MS, Vroon A, Sodaar P, van Muiswinkel FL, Heijnen CJ, Kavelaars A. Down-regulation of GRK2 after oxygen and glucose deprivation in rat hippocampal slices: role of the PI3-kinase pathway. J Neurochem. 2007 Aug; 102(3):731-40. PMID: 17437535.
      Citations: 8     Fields:    Translation:AnimalsCells
    167. Kleibeuker W, Ledeboer A, Eijkelkamp N, Watkins LR, Maier SF, Zijlstra J, Heijnen CJ, Kavelaars A. A role for G protein-coupled receptor kinase 2 in mechanical allodynia. Eur J Neurosci. 2007 Mar; 25(6):1696-704. PMID: 17408432.
      Citations: 24     Fields:    Translation:Animals
    168. Ter Wolbeek M, van Doornen LJ, Coffeng LE, Kavelaars A, Heijnen CJ. Cortisol and severe fatigue: a longitudinal study in adolescent girls. Psychoneuroendocrinology. 2007 Feb; 32(2):171-82. PMID: 17287088.
      Citations: 5     Fields:    Translation:Humans
    169. de Kloet CS, Vermetten E, Bikker A, Meulman E, Geuze E, Kavelaars A, Westenberg HG, Heijnen CJ. Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder. Mol Psychiatry. 2007 May; 12(5):443-53. PMID: 17245326.
      Citations: 28     Fields:    Translation:HumansCells
    170. Vroon A, Lombardi MS, Kavelaars A, Heijnen CJ. Taxol normalizes the impaired agonist-induced beta2-adrenoceptor internalization in splenocytes from GRK2+/- mice. Eur J Pharmacol. 2007 Mar 29; 560(1):9-16. PMID: 17303111.
      Citations: 5     Fields:    Translation:AnimalsCells
    171. Eijkelkamp N, Heijnen CJ, Lucas A, Premont RT, Elsenbruch S, Schedlowski M, Kavelaars A. G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Gut. 2007 Jun; 56(6):847-54. PMID: 17229795; PMCID: PMC1954868.
      Citations: 25     Fields:    Translation:AnimalsCells
    172. Nijboer CH, Kavelaars A, van Bel F, Heijnen CJ, Groenendaal F. Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat. Dev Neurosci. 2007; 29(4-5):385-92. PMID: 17762206.
      Citations: 16     Fields:    Translation:AnimalsCells
    173. Kamphuis PJ, de Vries WB, Bakker JM, Kavelaars A, van Dijk JE, Schipper ME, van Oosterhout MF, Croiset G, Heijnen CJ, van Bel F, Wiegant VM. Reduced life expectancy in rats after neonatal dexamethasone treatment. Pediatr Res. 2007 Jan; 61(1):72-6. PMID: 17211144.
      Citations: 13     Fields:    Translation:Animals
    174. Lucas A, Cobelens PM, Kavelaars A, Heijnen CJ, Holtmann G, Haag S, Gerken G, Langhorst J, Dobos GJ, Schedlowski M, Elsenbruch S. Disturbed in vitro adrenergic modulation of cytokine production in inflammatory bowel diseases in remission. J Neuroimmunol. 2007 Jan; 182(1-2):195-203. PMID: 17112600.
      Citations: 2     Fields:    Translation:HumansCells
    175. Mommersteeg PM, Heijnen CJ, Kavelaars A, van Doornen LJ. Immune and endocrine function in burnout syndrome. Psychosom Med. 2006 Nov-Dec; 68(6):879-86. PMID: 17079708.
      Citations: 16     Fields:    Translation:HumansCells
    176. Karemaker R, Heijnen CJ, Veen S, Baerts W, Samsom J, Visser GH, Kavelaars A, van Doornen LJ, van Bel F. Differences in behavioral outcome and motor development at school age after neonatal treatment for chronic lung disease with dexamethasone versus hydrocortisone. Pediatr Res. 2006 Dec; 60(6):745-50. PMID: 17065571.
      Citations: 21     Fields:    Translation:Humans
    177. del Rey A, Renigunta V, Dalpke AH, Leipziger J, Matos JE, Robaye B, Zuzarte M, Kavelaars A, Hanley PJ. Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages. J Biol Chem. 2006 Nov 17; 281(46):35147-55. PMID: 16980298.
      Citations: 23     Fields:    Translation:AnimalsCells
    178. Kavelaars A, Heijnen CJ, Ribas C, Mayor F, Penela P, Cobelens PM. Hydrogen peroxide impairs GRK2 translation via a calpain-dependent and cdk1-mediated pathway. Cell Signal. 2007 Feb; 19(2):269-77. PMID: 16963227.
      Citations: 10     Fields:    Translation:AnimalsCells
    179. Elsenbruch S, Lucas A, Holtmann G, Haag S, Gerken G, Riemenschneider N, Langhorst J, Kavelaars A, Heijnen CJ, Schedlowski M. Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndrome. Am J Gastroenterol. 2006 Oct; 101(10):2300-7. PMID: 16952284.
      Citations: 16     Fields:    Translation:Humans
    180. Vroon A, Heijnen CJ, Kavelaars A. GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol. 2006 Dec; 80(6):1214-21. PMID: 16943386.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    181. Krediet TG, Kavelaars A, Vreman HJ, Heijnen CJ, van Bel F. Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants. J Pediatr. 2006 Jun; 148(6):740-6. PMID: 16769379.
      Citations: 10     Fields:    Translation:HumansCells
    182. ter Wolbeek M, van Doornen LJ, Kavelaars A, Heijnen CJ. Severe fatigue in adolescents: a common phenomenon? Pediatrics. 2006 Jun; 117(6):e1078-86. PMID: 16740810.
      Citations: 40     Fields:    Translation:Humans
    183. Nijboer CH, Groenendaal F, Kavelaars A, Hagberg HH, van Bel F, Heijnen CJ. Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway. J Cereb Blood Flow Metab. 2007 Feb; 27(2):282-92. PMID: 16736041.
      Citations: 48     Fields:    Translation:AnimalsCells
    184. van den Tweel ER, Kavelaars A, Lombardi MS, Nijboer CH, Groenendaal F, van Bel F, Heijnen CJ. Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage. Pediatr Res. 2006 Mar; 59(3):434-9. PMID: 16492985.
      Citations: 20     Fields:    Translation:Animals
    185. Kavelaars A, Heijnen CJ. Stress, genetics, and immunity. Brain Behav Immun. 2006 Jul; 20(4):313-6. PMID: 16495034.
      Citations: 1     Fields:    Translation:HumansAnimals
    186. van den Tweel ER, Kavelaars A, Lombardi MS, Groenendaal F, May M, Heijnen CJ, van Bel F. Selective inhibition of nuclear factor-kappaB activation after hypoxia/ischemia in neonatal rats is not neuroprotective. Pediatr Res. 2006 Feb; 59(2):232-6. PMID: 16439584.
      Citations: 9     Fields:    Translation:AnimalsCells
    187. Lucas A, Holtmann G, Gerken G, Pietsch A, Braun-Lang U, Gilani K, Strassburger K, Gesing S, Janssen OE, Kavelaars A, Heijnen CJ, Schedlowski M, Elsenbruch S. Visceral pain and public speaking stress: neuroendocrine and immune cell responses in healthy subjects. Brain Behav Immun. 2006 Jan; 20(1):49-56. PMID: 16364816.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    188. Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg HG. Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder. Psychoneuroendocrinology. 2006 Apr; 31(3):355-60. PMID: 16249058.
      Citations: 3     Fields:    Translation:HumansCells
    189. Murga C, Kavelaars A, Krakstad BF, Heijnen CJ, Mayor F, Aragay AM, Jim?nez-Sainz MC, Jurado-Pueyo M. G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol Biol Cell. 2006 Jan; 17(1):25-31. PMID: 16221891; PMCID: PMC1345643.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    190. de Kloet CS, Vermetten E, Geuze E, Kavelaars A, Heijnen CJ, Westenberg HG. Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res. 2006 Sep; 40(6):550-67. PMID: 16214171.
      Citations: 147     Fields:    Translation:Humans
    191. van den Tweel ER, Nijboer C, Kavelaars A, Heijnen CJ, Groenendaal F, van Bel F. Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain. J Neuroimmunol. 2005 Oct; 167(1-2):64-71. PMID: 16112751.
      Citations: 18     Fields:    Translation:Animals
    192. Dulos J, Kaptein A, Kavelaars A, Heijnen C, Boots A. Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b. Arthritis Res Ther. 2005; 7(6):R1271-80. PMID: 16277680; PMCID: PMC1297571.
      Citations: 7     Fields:    Translation:HumansCells
    193. Kavelaars A, Cobelens PM, Teunis MA, Heijnen CJ. Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene. J Neuroimmunol. 2005 Apr; 161(1-2):162-8. PMID: 15748955.
      Citations: 16     Fields:    Translation:AnimalsCells
    194. Vroon A, Kavelaars A, Limmroth V, Lombardi MS, Goebel MU, Van Dam AM, Caron MG, Schedlowski M, Heijnen CJ. G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Immunol. 2005 Apr 01; 174(7):4400-6. PMID: 15778405.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    195. Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 2005 Mar; 52(3):770-8. PMID: 15751070.
      Citations: 18     Fields:    Translation:HumansCells
    196. van den Tweel ER, van Bel F, Kavelaars A, Peeters-Scholte CM, Haumann J, Nijboer CH, Heijnen CJ, Groenendaal F. Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats. J Cereb Blood Flow Metab. 2005 Jan; 25(1):67-74. PMID: 15678113.
      Citations: 15     Fields:    Translation:AnimalsCells
    197. Avitsur R, Kavelaars A, Heijnen C, Sheridan JF. Social stress and the regulation of tumor necrosis factor-alpha secretion. Brain Behav Immun. 2005 Jul; 19(4):311-7. PMID: 15944070.
      Citations: 52     Fields:    Translation:AnimalsCells
    198. Kavelaars A, van Meeteren N, Teunis M, Gispen WH, Heijnen C, Sajti E. Tumor angiogenesis and metastasis formation are associated with individual differences in behavior of inbred Lewis rats. Brain Behav Immun. 2004 Nov; 18(6):497-504. PMID: 15331120.
      Citations:    Fields:    Translation:AnimalsCells
    199. van Meeteren N, Kavelaars A, van der Net J, Gispen WH, Heijnen C, Sajti E. Individual differences in behavior of inbred Lewis rats are associated with severity of joint destruction in adjuvant-induced arthritis. Brain Behav Immun. 2004 Nov; 18(6):505-14. PMID: 15331121.
      Citations: 6     Fields:    Translation:Animals
    200. Teunis MA, Heijnen CJ, Cools AR, Kavelaars A. Reduced splenic natural killer cell activity in rats with a hyperreactive dopaminergic system. Psychoneuroendocrinology. 2004 Sep; 29(8):1058-64. PMID: 15219657.
      Citations: 7     Fields:    Translation:AnimalsCells
    201. Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg H. Decreased TNF-alpha and NK activity in obsessive-compulsive disorder. Psychoneuroendocrinology. 2004 Aug; 29(7):945-52. PMID: 15177711.
      Citations: 29     Fields:    Translation:HumansCellsCTClinical Trials
    202. Eijkelkamp N, Cobelens PM, Sanders VM, Heijnen CJ, Kavelaars A. Tissue specific effects of the beta 2-adrenergic agonist salbutamol on LPS-induced IFN-gamma, IL-10 and TGF-beta responses in vivo. J Neuroimmunol. 2004 May; 150(1-2):3-9. PMID: 15081243.
      Citations: 3     Fields:    Translation:Animals
    203. Lombardi MS, van den Tweel E, Kavelaars A, Groenendaal F, van Bel F, Heijnen CJ. Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain. Stroke. 2004 Apr; 35(4):981-6. PMID: 15017017.
      Citations: 16     Fields:    Translation:Animals
    204. Vroon A, Heijnen CJ, Lombardi MS, Cobelens PM, Mayor F, Caron MG, Kavelaars A. Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. J Leukoc Biol. 2004 May; 75(5):901-9. PMID: 14761932.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    205. Vroon A, Heijnen CJ, Raatgever R, Touw IP, Ploemacher RE, Premont RT, Kavelaars A. GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. J Leukoc Biol. 2004 Apr; 75(4):698-704. PMID: 14704365.
      Citations: 47     Fields:    Translation:AnimalsCells
    206. Haerter K, Vroon A, Kavelaars A, Heijnen CJ, Limmroth V, Espinosa E, Schedlowski M, Elsenbruch S. In vitro adrenergic modulation of cellular immune functions in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2004 Jan; 146(1-2):126-32. PMID: 14698854.
      Citations: 5     Fields:    Translation:Animals
    207. Kavelaars A, Vroon A, Raatgever RP, Fong AM, Premont RT, Patel DD, Lefkowitz RJ, Heijnen CJ. Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. J Immunol. 2003 Dec 01; 171(11):6128-34. PMID: 14634128.
      Citations: 32     Fields:    Translation:AnimalsCells
    208. Vroon A, Lombardi MS, Kavelaars A, Heijnen CJ. Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis. J Neuroimmunol. 2003 Apr; 137(1-2):79-86. PMID: 12667650.
      Citations: 18     Fields:    Translation:Animals
    209. Smeets MB, Fontijn J, Kavelaars A, Pasterkamp G, De Kleijn DP. The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues. Int J Exp Pathol. 2003 Apr; 84(2):69-74. PMID: 12801280; PMCID: PMC2517545.
      Citations: 16     Fields:    Translation:HumansAnimals
    210. Kavelaars A. Regulated expression of alpha-1 adrenergic receptors in the immune system. Brain Behav Immun. 2002 Dec; 16(6):799-807. PMID: 12480508.
      Citations: 27     Fields:    Translation:HumansAnimals
    211. Teunis MA, Heijnen CJ, Sluyter F, Bakker JM, Van Dam AM, Hof M, Cools AR, Kavelaars A. Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age. J Neuroimmunol. 2002 Dec; 133(1-2):30-8. PMID: 12446005.
      Citations: 14     Fields:    Translation:AnimalsCells
    212. Cobelens PM, Kavelaars A, Vroon A, Ringeling M, van der Zee R, van Eden W, Heijnen CJ. The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity. J Immunol. 2002 Nov 01; 169(9):5028-35. PMID: 12391218.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    213. Van Eden W, Van Der Zee R, Van Kooten P, Berlo SE, Cobelens PM, Kavelaars A, Heijnen CJ, Prakken B, Roord S, Albani S. Balancing the immune system: Th1 and Th2. Ann Rheum Dis. 2002 Nov; 61 Suppl 2:ii25-8. PMID: 12379616; PMCID: PMC1766722.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    214. Denys D, Kavelaars A, Heijnen CJ, Westenberg H. A case of venlafaxine-induced inhibition of T-lymphocyte proliferation. Psychopharmacology (Berl). 2002 Dec; 164(4):432. PMID: 12457275.
      Citations: 1     Fields:    Translation:HumansCells
    215. Bont L, Versteegh J, Swelsen WT, Heijnen CJ, Kavelaars A, Brus F, Draaisma JM, Pekelharing-Berghuis M, van Diemen-Steenvoorde RA, Kimpen JL. Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity. Pediatr Res. 2002 Sep; 52(3):363-7. PMID: 12193668.
      Citations: 57     Fields:    Translation:HumansCells
    216. Lombardi MS, Kavelaars A, Penela P, Scholtens EJ, Roccio M, Schmidt RE, Schedlowski M, Mayor F, Heijnen CJ. Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism. Mol Pharmacol. 2002 Aug; 62(2):379-88. PMID: 12130691.
      Citations: 17     Fields:    Translation:HumansCells
    217. Teunis MA, Kavelaars A, Voest E, Bakker JM, Ellenbroek BA, Cools AR, Heijnen CJ. Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system. FASEB J. 2002 Sep; 16(11):1465-7. PMID: 12205050.
      Citations: 22     Fields:    Translation:Animals
    218. Cobelens PM, Kavelaars A, van der Zee R, van Eden W, Heijnen CJ. Dynamics of mycobacterial HSP65-induced T-cell cytokine expression during oral tolerance induction in adjuvant arthritis. Rheumatology (Oxford). 2002 Jul; 41(7):775-9. PMID: 12096227.
      Citations: 5     Fields:    Translation:AnimalsCells
    219. Heijnen CJ, Rouppe van der Voort C, van de Pol M, Kavelaars A. Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells. J Neuroimmunol. 2002 Apr; 125(1-2):66-72. PMID: 11960642.
      Citations: 22     Fields:    Translation:HumansCells
    220. Lombardi MS, Kavelaars A, Heijnen CJ. Role and modulation of G protein-coupled receptor signaling in inflammatory processes. Crit Rev Immunol. 2002; 22(2):141-63. PMID: 12433131.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    221. van der Pompe G, Bernards N, Kavelaars A, Heijnen C. An exploratory study into the effect of exhausting bicycle exercise on endocrine and immune responses in post-menopausal women: relationships between vigour and plasma cortisol concentrations and lymphocyte proliferation following exercise. Int J Sports Med. 2001 Aug; 22(6):447-53. PMID: 11531039.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    222. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JM, Pekelharing-Berghuis M, van Diemen-Steenvoorde RA, Kimpen JL. Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. J Infect Dis. 2001 Aug 01; 184(3):355-8. PMID: 11443563.
      Citations: 44     Fields:    Translation:Humans
    223. Lombardi MS, Kavelaars A, Cobelens PM, Schmidt RE, Schedlowski M, Heijnen CJ. Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system. J Immunol. 2001 Feb 01; 166(3):1635-40. PMID: 11160205.
      Citations: 46     Fields:    Translation:AnimalsCells
    224. Bakker JM, Kavelaars A, Kamphuis PJ, Zijlstra J, van Bel F, Heijnen CJ. Neonatal dexamethasone treatment induces long-lasting changes in T-cell receptor vbeta repertoire in rats. J Neuroimmunol. 2001 Jan 01; 112(1-2):47-54. PMID: 11108932.
      Citations: 4     Fields:    Translation:AnimalsCells
    225. Cobelens PM, Heijnen CJ, Nieuwenhuis EE, Kramer PP, van der Zee R, van Eden W, Kavelaars A. Treatment of adjuvant-induced arthritis by oral administration of mycobacterial Hsp65 during disease. Arthritis Rheum. 2000 Dec; 43(12):2694-702. PMID: 11145027.
      Citations: 10     Fields:    Translation:AnimalsCells
    226. Bakker JM, Kavelaars A, Kamphuis PJ, Cobelens PM, van Vugt HH, van Bel F, Heijnen CJ. Neonatal dexamethasone treatment increases susceptibility to experimental autoimmune disease in adult rats. J Immunol. 2000 Nov 15; 165(10):5932-7. PMID: 11067955.
      Citations: 13     Fields:    Translation:AnimalsCells
    227. Nieuwenhuis EE, Visser MR, Kavelaars A, Cobelens PM, Fleer A, Harmsen W, Verhoef J, Akkermans LM, Heijnen CJ. Oral antibiotics as a novel therapy for arthritis: evidence for a beneficial effect of intestinal Escherichia coli. Arthritis Rheum. 2000 Nov; 43(11):2583-9. PMID: 11083284.
      Citations: 11     Fields:    Translation:AnimalsCells
    228. Roupe van der Voort C, Heijnen CJ, Wulffraat N, Kuis W, Kavelaars A. Stress induces increases in IL-6 production by leucocytes of patients with the chronic inflammatory disease juvenile rheumatoid arthritis: a putative role for alpha(1)-adrenergic receptors. J Neuroimmunol. 2000 Oct 02; 110(1-2):223-9. PMID: 11024553.
      Citations: 24     Fields:    Translation:HumansCells
    229. Knook L, Kavelaars A, Sinnema G, Kuis W, Heijnen CJ. High nocturnal melatonin in adolescents with chronic fatigue syndrome. J Clin Endocrinol Metab. 2000 Oct; 85(10):3690-2. PMID: 11061525.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    230. Rouppe van der Voort C, Kavelaars A, van de Pol M, Heijnen CJ. Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors. J Neuroimmunol. 2000 Aug 01; 108(1-2):82-91. PMID: 10900341.
      Citations: 18     Fields:    Translation:HumansCells
    231. Bont L, Kavelaars A, Heijnen CJ, van Vught AJ, Kimpen JL. Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis. J Infect Dis. 2000 May; 181(5):1772-5. PMID: 10823782.
      Citations: 13     Fields:    Translation:Humans
    232. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JT, Geelen SM, Kimpen JL. Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study. Am J Respir Crit Care Med. 2000 May; 161(5):1518-23. PMID: 10806148.
      Citations: 38     Fields:    Translation:HumansCells
    233. Kavelaars A, Kuis W, Knook L, Sinnema G, Heijnen CJ. Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome. J Clin Endocrinol Metab. 2000 Feb; 85(2):692-6. PMID: 10690878.
      Citations: 22     Fields:    Translation:HumansCells
    234. Kavelaars A, Heijnen CJ. Expression of preproenkephalin mRNA and production and secretion of enkephalins by human thymocytes. Ann N Y Acad Sci. 2000; 917:778-83. PMID: 11268407.
      Citations: 2     Fields:    Translation:HumansCells
    235. Pawlak CR, Jacobs R, Mikeska E, Ochsmann S, Lombardi MS, Kavelaars A, Heijnen CJ, Schmidt RE, Schedlowski M. Patients with systemic lupus erythematosus differ from healthy controls in their immunological response to acute psychological stress. Brain Behav Immun. 1999 Dec; 13(4):287-302. PMID: 10600217.
      Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
    236. Heijnen CJ, Kavelaars A. The importance of being receptive. J Neuroimmunol. 1999 Dec; 100(1-2):197-202. PMID: 10695730.
      Citations: 2     Fields:    Translation:HumansCells
    237. Kavelaars A, Heijnen CJ, Tennekes R, Bruggink JE, Koolhaas JM. Individual behavioral characteristics of wild-type rats predict susceptibility to experimental autoimmune encephalomyelitis. Brain Behav Immun. 1999 Dec; 13(4):279-86. PMID: 10600216.
      Citations: 12     Fields:    Translation:Animals
    238. Kavelaars A, van Der Voort CR, Heijnen CJ. Adrenergic receptor subtypes in human peripheral blood lymphocytes. Hypertension. 1999 Nov; 34(5):e5. PMID: 10567203.
      Citations: 1     Fields:    Translation:HumansCells
    239. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JT, Geelen SM, van Vught HJ, Kimpen JL. Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis. Eur Respir J. 1999 Jul; 14(1):144-9. PMID: 10489842.
      Citations: 41     Fields:    Translation:HumansCellsCTClinical Trials
    240. Duval EL, Kavelaars A, Veenhuizen L, van Vught AJ, van de Wal HJ, Heijnen CJ. Pro- and anti-inflammatory cytokine patterns during and after cardiac surgery in young children. Eur J Pediatr. 1999 May; 158(5):387-93. PMID: 10333121.
      Citations: 11     Fields:    Translation:HumansCells
    241. Lombardi MS, Kavelaars A, Schedlowski M, Bijlsma JW, Okihara KL, Van de Pol M, Ochsmann S, Pawlak C, Schmidt RE, Heijnen CJ. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J. 1999 Apr; 13(6):715-25. PMID: 10094932.
      Citations: 64     Fields:    Translation:HumansCells
    242. Kavelaars A, van der Pompe G, Bakker JM, van Hasselt PM, Cats B, Visser GH, Heijnen CJ. Altered immune function in human newborns after prenatal administration of betamethasone: enhanced natural killer cell activity and decreased T cell proliferation in cord blood. Pediatr Res. 1999 Mar; 45(3):306-12. PMID: 10088646.
      Citations: 21     Fields:    Translation:HumansCells
    243. Rouppe van der Voort C, Kavelaars A, van de Pol M, Heijnen CJ. Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes. J Neuroimmunol. 1999 Mar 01; 95(1-2):165-73. PMID: 10229127.
      Citations: 18     Fields:    Translation:HumansCells
    244. Kavelaars A, de Jong-de Vos van Steenwijk T, Kuis W, Heijnen CJ. The reactivity of the cardiovascular system and immunomodulation by catecholamines in juvenile chronic arthritis. Ann N Y Acad Sci. 1998 May 01; 840:698-704. PMID: 9629296.
      Citations: 5     Fields:    Translation:HumansAnimals
    245. Kuis W, Heijnen CJ, Sinnema G, Kavelaars A, van der Net J, Helders PJ. Pain in childhood rheumatic arthritis. Baillieres Clin Rheumatol. 1998 May; 12(2):229-44. PMID: 9890096.
      Citations: 1     Fields:    Translation:Humans
    246. Kamphuis S, Eriksson F, Kavelaars A, Zijlstra J, van de Pol M, Kuis W, Heijnen CJ. Role of endogenous pro-enkephalin A-derived peptides in human T cell proliferation and monocyte IL-6 production. J Neuroimmunol. 1998 Apr 01; 84(1):53-60. PMID: 9600708.
      Citations: 11     Fields:    Translation:HumansCells
    247. Bakker JM, van den Dobbelsteen GPJM, Kroes H, Kavelaars A, Heijnen CJ, Tilders FJH, van Rees EP. Long-term gender-specific effects of manipulation during pregnancy on immune and endocrine responsiveness in rat offspring. J Neuroimmunol. 1998 Feb; 82(1):56-63. PMID: 9526846.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    248. Kuis W, Kavelaars A, Prakken BJ, Wulffraat NM, Heijnen CJ. Dialogue between the brain and the immune system in juvenile chronic arthritis. Rev Rhum Engl Ed. 1997 Oct 15; 64(10 Suppl):146S-148S. PMID: 9385665.
      Citations: 1     Fields:    Translation:Humans
    249. Kamphuis S, Kavelaars A, Brooimans R, Kuis W, Zegers BJ, Heijnen CJ. T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells. J Neuroimmunol. 1997 Oct; 79(1):91-9. PMID: 9357452.
      Citations: 8     Fields:    Translation:HumansCells
    250. Kavelaars A, van de Pol M, Zijlstra J, Heijnen CJ. Beta 2-adrenergic activation enhances interleukin-8 production by human monocytes. J Neuroimmunol. 1997 Aug; 77(2):211-6. PMID: 9258252.
      Citations: 27     Fields:    Translation:HumansCells
    251. Prakken AB, van Hoeij MJ, Kuis W, Kavelaars A, Heynen CJ, Scholtens E, de Kleer IM, Rijkers GT, van Eden W. T-cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint. Immunol Lett. 1997 Jun 01; 57(1-3):139-42. PMID: 9232440.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    252. Kavelaars A, Heijnen CJ, Ellenbroek B, van Loveren H, Cools A. Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their susceptibility to inflammatory and infectious diseases: a study on rats with group-specific differences in structure and reactivity of hypothalamic-pituitary-adrenal axis. J Neurosci. 1997 Apr 01; 17(7):2580-4. PMID: 9065517; PMCID: PMC6573497.
      Citations: 7     Fields:    Translation:AnimalsCells
    253. Bakker JM, Schmidt ED, Kroes H, Kavelaars A, Heijnen CJ, Tilders FJ, van Rees EP. Effects of neonatal dexamethasone treatment on hypothalamo-pituitary adrenal axis and immune system of the rat. J Neuroimmunol. 1997 Apr; 74(1-2):69-76. PMID: 9119981.
      Citations: 7     Fields:    Translation:AnimalsCells
    254. Heijnen CJ, Rouppe van der Voort C, Wulffraat N, van der Net J, Kuis W, Kavelaars A. Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis. J Neuroimmunol. 1996 Dec; 71(1-2):223-6. PMID: 8982123.
      Citations: 34     Fields:    Translation:HumansCells
    255. Kuis W, de Jong-de Vos van Steenwijk C, Sinnema G, Kavelaars A, Prakken B, Helders PJ, Heijnen CJ. The autonomic nervous system and the immune system in juvenile rheumatoid arthritis. Brain Behav Immun. 1996 Dec; 10(4):387-98. PMID: 9045753.
      Citations: 21     Fields:    Translation:HumansCells
    256. Kavelaars A, Cats B, Visser GH, Zegers BJ, Bakker JM, van Rees EP, Heunen CJ. Ontogency of the responses of human peripheral blood T cells to glucocorticoids. Brain Behav Immun. 1996 Sep; 10(3):288-97. PMID: 8954600.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    257. Bakker JM, Schmidt ED, Kroes H, Kavelaars A, Heijnen CJ, Tilders FJ, van Rees EP. Effects of short-term dexamethasone treatment during pregnancy on the development of the immune system and the hypothalamo-pituitary adrenal axis in the rat. J Neuroimmunol. 1995 Dec 31; 63(2):183-91. PMID: 8550816.
      Citations: 11     Fields:    Translation:AnimalsCells
    258. Kavelaars A, Zijlstra J, Bakker JM, Van Rees EP, Visser GH, Zegers BJ, Heijnen CJ. Increased dexamethasone sensitivity of neonatal leukocytes: different mechanisms of glucocorticoid inhibition of T cell proliferation in adult and neonatal cells. Eur J Immunol. 1995 May; 25(5):1346-51. PMID: 7774638.
      Citations: 4     Fields:    Translation:HumansCells
    259. Kavelaars A, Broeke D, Jeurissen F, Kardux J, Meijer A, Franklin R, Gelfand EW, Heijnen CJ. Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production. J Immunol. 1994 Oct 15; 153(8):3691-9. PMID: 7930588.
      Citations: 11     Fields:    Translation:HumansCells
    260. Kavelaars A, Jeurissen F, Heijnen CJ. Substance P receptors and signal transduction in leukocytes. Immunomethods. 1994 Aug; 5(1):41-8. PMID: 7531101.
      Citations: 4     Fields:    Translation:HumansCells
    261. Jeurissen F, Kavelaars A, Korstjens M, Broeke D, Franklin RA, Gelfand EW, Heijnen CJ. Monocytes express a non-neurokinin substance P receptor that is functionally coupled to MAP kinase. J Immunol. 1994 Mar 15; 152(6):2987-94. PMID: 7511635.
      Citations: 2     Fields:    Translation:HumansCells
    262. Kavelaars A, Jeurissen F, Herman van Roijen J, Rijkers GT, Heijnen CJ, von Frijtag Drabbe K?nzel J. Substance P induces a rise in intracellular calcium concentration in human T lymphocytes in vitro: evidence of a receptor-independent mechanism. J Neuroimmunol. 1993 Jan; 42(1):61-70. PMID: 7678598.
      Citations: 3     Fields:    Translation:HumansCells
    263. Kavelaars A, Beetsma A, Heijnen CJ, Von Frijtag Drabbe K?nzel J. Beta-endorphin 1-17 modulates high affinity IL-2 receptor expression on human T cells. Ann N Y Acad Sci. 1992 Apr 15; 650:234-8. PMID: 1376571.
      Citations:    Fields:    Translation:HumansCells
    264. Chiappelli F, Kavelaars A, Heijnen CJ. Beta-endorphin effects on membrane transduction in human lymphocytes. Ann N Y Acad Sci. 1992 Apr 15; 650:211-7. PMID: 1534974.
      Citations:    Fields:    Translation:HumansCells
    265. Heijnen CJ, Kavelaars A. The contribution of neuroendocrine substances to the immune response. Neth J Med. 1991 Oct; 39(3-4):281-94. PMID: 1791891.
      Citations: 2     Fields:    Translation:Humans
    266. Heijnen CJ, Kavelaars A, Kuis W. [The relationship between the neuroendocrine system and juvenile chronic arthritis: a hypothesis]. Tijdschr Kindergeneeskd. 1991 Oct; 59(5):182-5. PMID: 1720265.
      Citations:    Fields:    Translation:Humans
    267. Kavelaars A, Ballieux RE, Heijnen CJ. Two different signalling pathways for the induction of immunoreactive beta-endorphin secretion by human peripheral blood mononuclear cells. Endocrinology. 1991 Feb; 128(2):765-70. PMID: 1824933.
      Citations: 2     Fields:    Translation:HumansCells
    268. Heijnen CJ, Kavelaars A, Ballieux RE. Beta-endorphin: cytokine and neuropeptide. Immunol Rev. 1991 Feb; 119:41-63. PMID: 2045122.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    269. Kavelaars A, Ballieux RE, Heijnen CJ. Differential effects of beta-endorphin on cAMP levels in human peripheral blood mononuclear cells. Brain Behav Immun. 1990 Sep; 4(3):171-9. PMID: 1964616.
      Citations: 5     Fields:    Translation:HumansCells
    270. Kavelaars A, Ballieux RE, Heijnen CJ. In vitro beta-adrenergic stimulation of lymphocytes induces the release of immunoreactive beta-endorphin. Endocrinology. 1990 Jun; 126(6):3028-32. PMID: 2161745.
      Citations: 6     Fields:    Translation:HumansCells
    271. Kavelaars A, Eggen BJ, De Graan PN, Gispen WH, Heijnen CJ. The phosphorylation of the CD3 gamma chain of T lymphocytes is modulated by beta-endorphin. Eur J Immunol. 1990 Apr; 20(4):943-5. PMID: 2140792.
      Citations: 1     Fields:    Translation:HumansCells
    272. Kavelaars A, Ballieux RE, Heijnen CJ. Beta-endorphin production by lymphocytes. Int J Neurosci. 1990 Apr; 51(3-4):173-5. PMID: 2279862.
      Citations:    Fields:    Translation:HumansCells
    273. Kavelaars A, Berkenbosch F, Croiset G, Ballieux RE, Heijnen CJ. Induction of beta-endorphin secretion by lymphocytes after subcutaneous administration of corticotropin-releasing factor. Endocrinology. 1990 Feb; 126(2):759-64. PMID: 2137081.
      Citations: 6     Fields:    Translation:AnimalsCells
    274. Kavelaars A, Ballieux RE, Heijnen CJ. Beta-endorphin secretion by human peripheral blood mononuclear cells: regulation by glucocorticoids. Life Sci. 1990; 46(17):1233-40. PMID: 2140145.
      Citations: 5     Fields:    Translation:HumansCells
    275. Kavelaars A, Ballieux RE, Heijnen CJ. The role of IL-1 in the corticotropin-releasing factor and arginine- vasopressin-induced secretion of immunoreactive beta-endorphin by human peripheral blood mononuclear cells. J Immunol. 1989 Apr 01; 142(7):2338-42. PMID: 2522482.
      Citations: 20     Fields:    Translation:HumansCells
    276. Kavelaars A, Ballieux RE, Heijnen C. Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation. Brain Behav Immun. 1988 Mar; 2(1):57-66. PMID: 3263158.
      Citations: 2     Fields:    Translation:HumansCells
    277. Heijnen CJ, Zijlstra J, Kavelaars A, Croiset G, Ballieux RE. Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes. Brain Behav Immun. 1987 Dec; 1(4):284-91. PMID: 2839258.
      Citations: 10     Fields:    Translation:HumansCells
    278. Heijnen CJ, Bevers C, Kavelaars A, Ballieux RE. Effect of alpha-endorphin on the antigen-induced primary antibody response of human blood B cells in vitro. J Immunol. 1986 Jan; 136(1):213-6. PMID: 2415618.
      Citations: 5     Fields:    Translation:HumansCells
    279. Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2. Science Signaling. 8.
    280. Adrenergic regulation of immunity. 63-83.
    281. Interactions between corticotropin-releasing hormone and interleukin-1 in the immune system. Annals of the New York Academy of Sciences. 594:368-370.
    282. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proceedings of the National Academy of Sciences of the United States of America. 113:3036-3041.
    283. Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse. Pediatric Research. 78:520-526.
    284. Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. Current Neuropharmacology. 8:324-334.
    285. IL4-10 fusion protein is a Novel drug to Treat persistent inflammatory pain. Journal of Neuroscience. 36:7353-7363.
    286. Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ. Pain. 156:2184-2192.
    287. Immuunmodulerende effecten van leukocyten-verwijdering bij neonatale bloedtransfusie. Tijdschrift voor Kindergeneeskunde. 66:5-6.
    288. Regulation of Target System Sensitivity in Neuroinflammation.
    289. Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1. Scientific Reports. 6.
    290. Mechanisms of chemotherapy-induced behavioral toxicities. Frontiers in Neuroscience. 9.
    291. CD8+ T cells and endogenous IL-10 are required for resolution of chemotherapy-induced neuropathic pain. Journal of Neuroscience. 36:11074-11083.
    292. Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression. Behavioural Brain Research. 297:241-250.
    293. Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain, Behavior, and Immunity. 46:147-153.
    294. Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy. Journal of Pain. 17:775-786.
    295. Metformin prevents cisplatin-induced cognitive impairment and brain damage in mice. PLoS One. 11.
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