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NICHOLAS NAVIN

TitleAssociate Professor
InstitutionMD Anderson
DepartmentGenetics
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang K, Yan Y, Elgamal H, Li J, Tang C, Bai S, Xiao Z, Sei E, Lin Y, Wang J, Montalvan J, Nagi C, Thompson AM, Navin N. Single cell genome and epigenome co-profiling reveals hardwiring and plasticity in breast cancer. bioRxiv. 2024 Sep 10. PMID: 39314325; PMCID: PMC11418942.
      Citations:    
    2. Gupta P, Dang M, Oberai S, Migliozzi S, Trivedi R, Kumar G, Peshoff M, Milam N, Ahmed A, Bojja K, Tran TM, Gumin J, Kamiya-Matsuoka C, Huse J, Cox K, Li J, Shehwana H, Sheth SA, Saxon R, Baohua S, Parker-Kerrigan B, Maheshwari A, Parra Cuentas ER, Navin NE, Heimberger AB, Lang FF, Iavarone A, Clise-Dwyer K, Wang L, Bhat KP. Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. Neuro Oncol. 2024 Aug 10. PMID: 39126294.
      Citations: 2     Fields:    
    3. Dou J, Tan Y, Kock KH, Wang J, Cheng X, Tan LM, Han KY, Hon CC, Park WY, Shin JW, Jin H, Wang Y, Chen H, Ding L, Prabhakar S, Navin N, Chen R, Chen K. Single-nucleotide variant calling in single-cell sequencing data with Monopogen. Nat Biotechnol. 2024 May; 42(5):803-812. PMID: 37592035; PMCID: PMC11098741.
      Citations: 3     Fields:    
    4. Wang K, Kumar T, Wang J, Minussi DC, Sei E, Li J, Tran TM, Thennavan A, Hu M, Casasent AK, Xiao Z, Bai S, Yang L, King LM, Shah V, Kristel P, van der Borden CL, Marks JR, Zhao Y, Zurita AJ, Aparicio A, Chapin B, Ye J, Zhang J, Gibbons DL, Grand Challenge PRECISION Consortium, Sawyer E, Thompson AM, Futreal A, Hwang ES, Wesseling J, Lips EH, Navin NE. Archival single-cell genomics reveals persistent subclones during DCIS progression. Cell. 2023 08 31; 186(18):3968-3982.e15. PMID: 37586362.
      Citations: 2     Fields:    Translation:HumansCells
    5. Kumar T, Nee K, Wei R, He S, Nguyen QH, Bai S, Blake K, Pein M, Gong Y, Sei E, Hu M, Casasent AK, Thennavan A, Li J, Tran T, Chen K, Nilges B, Kashikar N, Braubach O, Ben Cheikh B, Nikulina N, Chen H, Teshome M, Menegaz B, Javaid H, Nagi C, Montalvan J, Lev T, Mallya S, Tifrea DF, Edwards R, Lin E, Parajuli R, Hanson S, Winocour S, Thompson A, Lim B, Lawson DA, Kessenbrock K, Navin N. A spatially resolved single-cell genomic atlas of the adult human breast. Nature. 2023 Aug; 620(7972):181-191. PMID: 37380767; PMCID: PMC11443819.
      Citations: 16     Fields:    Translation:HumansCells
    6. Lu L, Wang JR, Henderson YC, Bai S, Yang J, Hu M, Shiau CK, Pan T, Yan Y, Tran TM, Li J, Kieser R, Zhao X, Wang J, Nurieva R, Williams MD, Cabanillas ME, Dadu R, Busaidy NL, Zafereo M, Navin N, Lai SY, Gao R. Anaplastic transformation in thyroid cancer revealed by single-cell transcriptomics. J Clin Invest. 2023 06 01; 133(11). PMID: 37053016; PMCID: PMC10231997.
      Citations: 3     Fields:    Translation:HumansCells
    7. Truong DD, Lamhamedi-Cherradi SE, Porter RW, Krishnan S, Swaminathan J, Gibson A, Lazar AJ, Livingston JA, Gopalakrishnan V, Gordon N, Daw NC, Navin NE, Gorlick R, Ludwig JA. Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing. BMC Cancer. 2023 May 31; 23(1):488. PMID: 37254069; PMCID: PMC10230784.
      Citations: 1     Fields:    Translation:HumansCells
    8. Gencel-Augusto J, Su X, Qi Y, Whitley EM, Pant V, Xiong S, Shah V, Lin J, Perez E, Fiorotto ML, Mahmud I, Jain AK, Lorenzi PL, Navin NE, Richie ER, Lozano G. Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program. Cancer Discov. 2023 05 04; 13(5):1230-1249. PMID: 37067911; PMCID: PMC10164062.
      Citations: 3     Fields:    Translation:Animals
    9. Kumar T, Nee K, Wei R, He S, Nguyen QH, Bai S, Blake K, Gong Y, Pein M, Sei E, Hu M, Casasent A, Thennavan A, Li J, Tran T, Chen K, Nilges B, Kashikar N, Braubach O, Cheikh BB, Nikulina N, Chen H, Teshome M, Menegaz B, Javaid H, Nagi C, Montalvan J, Tifrea DF, Edwards R, Lin E, Parajuli R, Winocour S, Thompson A, Lim B, Lawson DA, Kessenbrock K, Navin N. A spatially resolved single cell genomic atlas of the adult human breast. bioRxiv. 2023 Apr 25. PMID: 37163043; PMCID: PMC10168262.
      Citations:    
    10. Casasent AK, Almekinders MM, Mulder C, Bhattacharjee P, Collyar D, Thompson AM, Jonkers J, Lips EH, van Rheenen J, Hwang ES, Nik-Zainal S, Navin NE, Wesseling J, Grand Challenge PRECISION Consortium. Author Correction: Learning to distinguish progressive and non-progressive ductal carcinoma in situ. Nat Rev Cancer. 2023 Feb; 23(2):112. PMID: 36522469.
      Citations:    Fields:    
    11. Gulhati P, Schalck A, Jiang S, Shang X, Wu CJ, Hou P, Ruiz SH, Soto LS, Parra E, Ying H, Han J, Dey P, Li J, Deng P, Sei E, Maeda DY, Zebala JA, Spring DJ, Kim M, Wang H, Maitra A, Moore D, Clise-Dwyer K, Wang YA, Navin NE, DePinho RA. Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer. Nat Cancer. 2023 01; 4(1):62-80. PMID: 36585453; PMCID: PMC9925045.
      Citations: 11     Fields:    Translation:HumansCells
    12. Wang X, Semba T, Manyam GC, Wang J, Shao S, Bertucci F, Finetti P, Krishnamurthy S, Phi LTH, Pearson T, Van Laere SJ, Burks JK, Cohen EN, Reuben JM, Yang F, Min H, Navin N, Trinh VN, Iwase T, Batra H, Shen Y, Zhang X, Tripathy D, Ueno NT. EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer. Sci Adv. 2022 12 16; 8(50):eabn7983. PMID: 36525493; PMCID: PMC9757751.
      Citations: 4     Fields:    Translation:Animals
    13. Kaufmann TL, Petkovic M, Watkins TBK, Colliver EC, Laskina S, Thapa N, Minussi DC, Navin N, Swanton C, Van Loo P, Haase K, Tarabichi M, Schwarz RF. MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution. Genome Biol. 2022 11 14; 23(1):241. PMID: 36376909; PMCID: PMC9661799.
      Citations: 12     Fields:    Translation:Humans
    14. Leighton J, Hu M, Sei E, Meric-Bernstam F, Navin NE. Reconstructing mutational lineages in breast cancer by multi-patient-targeted single-cell DNA sequencing. Cell Genom. 2023 Jan 11; 3(1):100215. PMID: 36777188; PMCID: PMC9903705.
      Citations: 2     
    15. Casasent AK, Almekinders MM, Mulder C, Bhattacharjee P, Collyar D, Thompson AM, Jonkers J, Lips EH, van Rheenen J, Hwang ES, Nik-Zainal S, Navin NE, Wesseling J, Grand Challenge PRECISION Consortium. Learning to distinguish progressive and non-progressive ductal carcinoma in situ. Nat Rev Cancer. 2022 12; 22(12):663-678. PMID: 36261705.
      Citations: 5     Fields:    Translation:Humans
    16. Schalck A, Sakellariou-Thompson D, Sei E, Hughes TG, Reuben A, Bai S, Hu M, Kumar T, Hurd MW, Katz MHG, Tzeng CD, Pant S, Javle M, Fogelman DR, Maitra A, Haymaker CL, Kim MP, Navin NE, Bernatchez C, Forget MA. Single-Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer. Cancer Discov. 2022 10 05; 12(10):2330-2349. PMID: 35849783; PMCID: PMC9547957.
      Citations:    Fields:    
    17. Wu HJ, Temko D, Maliga Z, Moreira AL, Sei E, Minussi DC, Dean J, Lee C, Xu Q, Hochart G, Jacobson CA, Yapp C, Schapiro D, Sorger PK, Seeley EH, Navin N, Downey RJ, Michor F. Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients. Cell Genom. 2022 Aug 10; 2(8). PMID: 36419822; PMCID: PMC9681138.
      Citations: 3     
    18. Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 09; 24(9):1031-1040. PMID: 35718094.
      Citations:    Fields:    
    19. Lips EH, Kumar T, Megalios A, Visser LL, Sheinman M, Fortunato A, Shah V, Hoogstraat M, Sei E, Mallo D, Roman-Escorza M, Ahmed AA, Xu M, van den Belt-Dusebout AW, Brugman W, Casasent AK, Clements K, Davies HR, Fu L, Grigoriadis A, Hardman TM, King LM, Krete M, Kristel P, de Maaker M, Maley CC, Marks JR, Menegaz BA, Mulder L, Nieboer F, Nowinski S, Pinder S, Quist J, Salinas-Souza C, Schaapveld M, Schmidt MK, Shaaban AM, Shami R, Sridharan M, Zhang J, Stobart H, Collyar D, Nik-Zainal S, Wessels LFA, Hwang ES, Navin NE, Futreal PA, Grand Challenge PRECISION consortium, Thompson AM, Wesseling J, Sawyer EJ. Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer. Nat Genet. 2022 06; 54(6):850-860. PMID: 35681052; PMCID: PMC9197769.
      Citations:    Fields:    Translation:Humans
    20. Han H, Wang Y, Curto J, Gurrapu S, Laudato S, Rumandla A, Chakraborty G, Wang X, Chen H, Jiang Y, Kumar D, Caggiano EG, Capogiri M, Zhang B, Ji Y, Maity SN, Hu M, Bai S, Aparicio AM, Efstathiou E, Logothetis CJ, Navin N, Navone NM, Chen Y, Giancotti FG. Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis. Cell Rep. 2022 04 05; 39(1):110595. PMID: 35385726; PMCID: PMC9414743.
      Citations:    Fields:    Translation:HumansAnimalsCells
    21. Wei R, He S, Bai S, Sei E, Hu M, Thompson A, Chen K, Krishnamurthy S, Navin NE. Spatial charting of single-cell transcriptomes in tissues. Nat Biotechnol. 2022 08; 40(8):1190-1199. PMID: 35314812; PMCID: PMC9673606.
      Citations: 1     Fields:    
    22. Wang K, Xiao Z, Yan Y, Ye R, Hu M, Bai S, Sei E, Qiao Y, Chen H, Lim B, Lin SH, Navin NE. Simple oligonucleotide-based multiplexing of single-cell chromatin accessibility. Mol Cell. 2021 10 21; 81(20):4319-4332.e10. PMID: 34686316; PMCID: PMC8611914.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    23. Johnson KC, Anderson KJ, Courtois ET, Gujar AD, Barthel FP, Varn FS, Luo D, Seignon M, Yi E, Kim H, Estecio MRH, Zhao D, Tang M, Navin NE, Maurya R, Ngan CY, Verburg N, de Witt Hamer PC, Bulsara K, Samuels ML, Das S, Robson P, Verhaak RGW. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response. Nat Genet. 2021 10; 53(10):1456-1468. PMID: 34594038; PMCID: PMC8570135.
      Citations: 9     Fields:    Translation:HumansCells
    24. Morita K, Wang F, Jahn K, Hu T, Tanaka T, Sasaki Y, Kuipers J, Loghavi S, Wang SA, Yan Y, Furudate K, Matthews J, Little L, Gumbs C, Zhang J, Song X, Thompson E, Patel KP, Bueso-Ramos CE, DiNardo CD, Ravandi F, Jabbour E, Andreeff M, Cortes J, Bhalla K, Garcia-Manero G, Kantarjian H, Konopleva M, Nakada D, Navin N, Beerenwinkel N, Futreal PA, Takahashi K. Author Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2021 May 10; 12(1):2823. PMID: 33972555; PMCID: PMC8110810.
      Citations: 1     Fields:    
    25. Minussi DC, Nicholson MD, Ye H, Davis A, Wang K, Baker T, Tarabichi M, Sei E, Du H, Rabbani M, Peng C, Hu M, Bai S, Lin YW, Schalck A, Multani A, Ma J, McDonald TO, Casasent A, Barrera A, Chen H, Lim B, Arun B, Meric-Bernstam F, Van Loo P, Michor F, Navin NE. Breast tumours maintain a reservoir of subclonal diversity during expansion. Nature. 2021 04; 592(7853):302-308. PMID: 33762732; PMCID: PMC8049101.
      Citations: 24     Fields:    Translation:HumansCells
    26. Wang F, Wang Q, Mohanty V, Liang S, Dou J, Han J, Minussi DC, Gao R, Ding L, Navin N, Chen K. MEDALT: single-cell copy number lineage tracing enabling gene discovery. Genome Biol. 2021 02 23; 22(1):70. PMID: 33622385; PMCID: PMC7901082.
      Citations: 4     Fields:    Translation:Humans
    27. Gao R, Bai S, Henderson YC, Lin Y, Schalck A, Yan Y, Kumar T, Hu M, Sei E, Davis A, Wang F, Shaitelman SF, Wang JR, Chen K, Moulder S, Lai SY, Navin NE. Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes. Nat Biotechnol. 2021 05; 39(5):599-608. PMID: 33462507; PMCID: PMC8122019.
      Citations: 44     Fields:    Translation:HumansCells
    28. Morita K, Wang F, Jahn K, Hu T, Tanaka T, Sasaki Y, Kuipers J, Loghavi S, Wang SA, Yan Y, Furudate K, Matthews J, Little L, Gumbs C, Zhang J, Song X, Thompson E, Patel KP, Bueso-Ramos CE, DiNardo CD, Ravandi F, Jabbour E, Andreeff M, Cortes J, Bhalla K, Garcia-Manero G, Kantarjian H, Konopleva M, Nakada D, Navin N, Beerenwinkel N, Futreal PA, Takahashi K. Publisher Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2020 Nov 19; 11(1):5996. PMID: 33214561; PMCID: PMC7677309.
      Citations: 3     Fields:    
    29. Naffar-Abu Amara S, Kuiken HJ, Selfors LM, Butler T, Leung ML, Leung CT, Kuhn EP, Kolarova T, Hage C, Ganesh K, Panayiotou R, Foster R, Rueda BR, Aktipis A, Spellman P, Ince TA, Xiu J, Oberley M, Gatalica Z, Navin N, Mills GB, Bronson RT, Brugge JS. Transient commensal clonal interactions can drive tumor metastasis. Nat Commun. 2020 11 16; 11(1):5799. PMID: 33199705; PMCID: PMC7669858.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    30. Morita K, Wang F, Jahn K, Hu T, Tanaka T, Sasaki Y, Kuipers J, Loghavi S, Wang SA, Yan Y, Furudate K, Matthews J, Little L, Gumbs C, Zhang J, Song X, Thompson E, Patel KP, Bueso-Ramos CE, DiNardo CD, Ravandi F, Jabbour E, Andreeff M, Cortes J, Bhalla K, Garcia-Manero G, Kantarjian H, Konopleva M, Nakada D, Navin N, Beerenwinkel N, Futreal PA, Takahashi K. Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2020 10 21; 11(1):5327. PMID: 33087716; PMCID: PMC7577981.
      Citations: 66     Fields:    Translation:HumansAnimals
    31. Mallory XF, Edrisi M, Navin N, Nakhleh L. Methods for copy number aberration detection from single-cell DNA-sequencing data. Genome Biol. 2020 08 17; 21(1):208. PMID: 32807205; PMCID: PMC7433197.
      Citations: 23     Fields:    Translation:HumansCells
    32. Manzo T, Prentice BM, Anderson KG, Raman A, Schalck A, Codreanu GS, Nava Lauson CB, Tiberti S, Raimondi A, Jones MA, Reyzer M, Bates BM, Spraggins JM, Patterson NH, McLean JA, Rai K, Tacchetti C, Tucci S, Wargo JA, Rodighiero S, Clise-Dwyer K, Sherrod SD, Kim M, Navin NE, Caprioli RM, Greenberg PD, Draetta G, Nezi L. Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells. J Exp Med. 2020 08 03; 217(8). PMID: 32491160; PMCID: PMC7398173.
      Citations: 30     Fields:    Translation:AnimalsCells
    33. Mallory XF, Edrisi M, Navin N, Nakhleh L. Assessing the performance of methods for copy number aberration detection from single-cell DNA sequencing data. PLoS Comput Biol. 2020 07; 16(7):e1008012. PMID: 32658894; PMCID: PMC7377518.
      Citations: 7     Fields:    Translation:Humans
    34. Ramesh N, Sei E, Tsai PC, Bai S, Zhao Y, Troncoso P, Corn PG, Logothetis C, Zurita AJ, Navin NE. Decoding the evolutionary response to prostate cancer therapy by plasma genome sequencing. Genome Biol. 2020 07 06; 21(1):162. PMID: 32631448; PMCID: PMC7336456.
      Citations: 3     Fields:    Translation:Humans
    35. Malihi PD, Graf RP, Rodriguez A, Ramesh N, Lee J, Sutton R, Jiles R, Ruiz Velasco C, Sei E, Kolatkar A, Logothetis C, Navin NE, Corn P, Aparicio AM, Dittamore R, Hicks J, Kuhn P, Zurita AJ. Single-Cell Circulating Tumor Cell Analysis Reveals Genomic Instability as a Distinctive Feature of Aggressive Prostate Cancer. Clin Cancer Res. 2020 08 01; 26(15):4143-4153. PMID: 32341031; PMCID: PMC8043601.
      Citations: 25     Fields:    Translation:HumansCellsCTClinical Trials
    36. Mitra A, Andrews MC, Roh W, De Macedo MP, Hudgens CW, Carapeto F, Singh S, Reuben A, Wang F, Mao X, Song X, Wani K, Tippen S, Ng KS, Schalck A, Sakellariou-Thompson DA, Chen E, Reddy SM, Spencer CN, Wiesnoski D, Little LD, Gumbs C, Cooper ZA, Burton EM, Hwu P, Davies MA, Zhang J, Bernatchez C, Navin N, Sharma P, Allison JP, Wargo JA, Yee C, Tetzlaff MT, Hwu WJ, Lazar AJ, Futreal PA. Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma. Nat Commun. 2020 04 15; 11(1):1839. PMID: 32296058; PMCID: PMC7160105.
      Citations: 5     Fields:    Translation:Humans
    37. Lim B, Lin Y, Navin N. Advancing Cancer Research and Medicine with Single-Cell Genomics. Cancer Cell. 2020 04 13; 37(4):456-470. PMID: 32289270; PMCID: PMC7899145.
      Citations: 58     Fields:    Translation:Humans
    38. Davis A, Gao R, Navin NE. SCOPIT: sample size calculations for single-cell sequencing experiments. BMC Bioinformatics. 2019 Nov 12; 20(1):566. PMID: 31718533; PMCID: PMC6852764.
      Citations: 9     Fields:    Translation:Humans
    39. Wang F, Liang S, Kumar T, Navin N, Chen K. SCMarker: Ab initio marker selection for single cell transcriptome profiling. PLoS Comput Biol. 2019 10; 15(10):e1007445. PMID: 31658262; PMCID: PMC6837541.
      Citations: 8     Fields:    Translation:HumansCells
    40. Zafar H, Navin N, Chen K, Nakhleh L. SiCloneFit: Bayesian inference of population structure, genotype, and phylogeny of tumor clones from single-cell genome sequencing data. Genome Res. 2019 11; 29(11):1847-1859. PMID: 31628257; PMCID: PMC6836738.
      Citations: 29     Fields:    Translation:HumansCells
    41. Corn PG, Heath EI, Zurita A, Ramesh N, Xiao L, Sei E, Li-Ning-Tapia E, Tu SM, Subudhi SK, Wang J, Wang X, Efstathiou E, Thompson TC, Troncoso P, Navin N, Logothetis CJ, Aparicio AM. Cabazitaxel plus carboplatin for the treatment of men with metastatic castration-resistant prostate cancers: a randomised, open-label, phase 1-2 trial. Lancet Oncol. 2019 10; 20(10):1432-1443. PMID: 31515154; PMCID: PMC6858999.
      Citations: 37     Fields:    Translation:HumansCTClinical Trials
    42. Zafar H, Tzen A, Navin N, Chen K, Nakhleh L. Comments on the model parameters in "SiFit: inferring tumor trees from single-cell sequencing data under finite-sites models". Genome Biol. 2019 05 16; 20(1):95. PMID: 31096998; PMCID: PMC6524219.
      Citations:    Fields:    Translation:HumansAnimals
    43. Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nat Commun. 2018 09 27; 9(1):3953. PMID: 30262850; PMCID: PMC6160420.
      Citations: 16     Fields:    Translation:HumansAnimals
    44. Schalck A, Bernatchez C, Navin N. Resident Breast T Cells: The Troops Are Already There. Trends Mol Med. 2018 10; 24(10):821-822. PMID: 30077643; PMCID: PMC6168353.
      Citations: 1     Fields:    Translation:HumansCells
    45. Kim C, Gao R, Sei E, Brandt R, Hartman J, Hatschek T, Crosetto N, Foukakis T, Navin NE. Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing. Cell. 2018 05 03; 173(4):879-893.e13. PMID: 29681456; PMCID: PMC6132060.
      Citations: 309     Fields:    Translation:HumansCells
    46. Casasent AK, Schalck A, Gao R, Sei E, Long A, Pangburn W, Casasent T, Meric-Bernstam F, Edgerton ME, Navin NE. Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing. Cell. 2018 01 11; 172(1-2):205-217.e12. PMID: 29307488; PMCID: PMC5766405.
      Citations: 140     Fields:    Translation:Humans
    47. Zafar H, Tzen A, Navin N, Chen K, Nakhleh L. SiFit: inferring tumor trees from single-cell sequencing data under finite-sites models. Genome Biol. 2017 09 19; 18(1):178. PMID: 28927434; PMCID: PMC5606061.
      Citations: 53     Fields:    Translation:Humans
    48. Gao R, Kim C, Sei E, Foukakis T, Crosetto N, Chan LK, Srinivasan M, Zhang H, Meric-Bernstam F, Navin N. Nanogrid single-nucleus RNA sequencing reveals phenotypic diversity in breast cancer. Nat Commun. 2017 08 09; 8(1):228. PMID: 28794488; PMCID: PMC5550415.
      Citations: 56     Fields:    Translation:HumansCells
    49. Gausachs M, Borras E, Chang K, Gonzalez S, Azuara D, Delgado Amador A, Lopez-Doriga A, San Lucas FA, Sanjuan X, Paules MJ, Taggart MW, Davies GE, Ehli EA, Fowler J, Moreno V, Pineda M, You YN, Lynch PM, Lazaro C, Navin NE, Scheet PA, Hawk ET, Capella G, Vilar E. Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis. Clin Cancer Res. 2017 Oct 01; 23(19):5936-5947. PMID: 28645942; PMCID: PMC5626604.
      Citations: 14     Fields:    Translation:Humans
    50. Leung ML, Davis A, Gao R, Casasent A, Wang Y, Sei E, Vilar E, Maru D, Kopetz S, Navin NE. Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer. Genome Res. 2017 08; 27(8):1287-1299. PMID: 28546418; PMCID: PMC5538546.
      Citations: 92     Fields:    Translation:HumansCells
    51. Davis A, Gao R, Navin N. Tumor evolution: Linear, branching, neutral or punctuated? Biochim Biophys Acta Rev Cancer. 2017 Apr; 1867(2):151-161. PMID: 28110020; PMCID: PMC5558210.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    52. Casasent AK, Edgerton M, Navin NE. Genome evolution in ductal carcinoma in situ: invasion of the clones. J Pathol. 2017 Jan; 241(2):208-218. PMID: 27861897; PMCID: PMC5558847.
      Citations: 35     Fields:    Translation:HumansAnimals
    53. Chen X, Love JC, Navin NE, Pachter L, Stubbington MJ, Svensson V, Sweedler JV, Teichmann SA. Single-cell analysis at the threshold. Nat Biotechnol. 2016 11 08; 34(11):1111-1118. PMID: 27824834.
      Citations: 28     Fields:    
    54. Gao R, Davis A, McDonald TO, Sei E, Shi X, Wang Y, Tsai PC, Casasent A, Waters J, Zhang H, Meric-Bernstam F, Michor F, Navin NE. Punctuated copy number evolution and clonal stasis in triple-negative breast cancer. Nat Genet. 2016 10; 48(10):1119-30. PMID: 27526321; PMCID: PMC5042845.
      Citations: 191     Fields:    Translation:HumansCells
    55. Mann KM, Newberg JY, Black MA, Jones DJ, Amaya-Manzanares F, Guzman-Rojas L, Kodama T, Ward JM, Rust AG, van der Weyden L, Yew CC, Waters JL, Leung ML, Rogers K, Rogers SM, McNoe LA, Selvanesan L, Navin N, Jenkins NA, Copeland NG, Mann MB. Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq. Nat Biotechnol. 2016 09; 34(9):962-72. PMID: 27479497; PMCID: PMC6124494.
      Citations: 21     Fields:    Translation:AnimalsCells
    56. Navin NE, Chen K. Genotyping tumor clones from single-cell data. Nat Methods. 2016 06 29; 13(7):555-6. PMID: 27355792.
      Citations: 5     Fields:    Translation:HumansCells
    57. Davis A, Navin NE. Computing tumor trees from single cells. Genome Biol. 2016 05 26; 17(1):113. PMID: 27230879; PMCID: PMC4881295.
      Citations: 15     Fields:    Translation:Humans
    58. Zafar H, Wang Y, Nakhleh L, Navin N, Chen K. Monovar: single-nucleotide variant detection in single cells. Nat Methods. 2016 06; 13(6):505-7. PMID: 27088313; PMCID: PMC4887298.
      Citations: 64     Fields:    Translation:HumansCells
    59. Baslan T, Kendall J, Rodgers L, Cox H, Riggs M, Stepansky A, Troge J, Ravi K, Esposito D, Lakshmi B, Wigler M, Navin N, Hicks J. Corrigendum: Genome-wide copy number analysis of single cells. Nat Protoc. 2016 Mar; 11(3):616. PMID: 26914320.
      Citations: 9     Fields:    
    60. Leung ML, Wang Y, Kim C, Gao R, Jiang J, Sei E, Navin NE. Highly multiplexed targeted DNA sequencing from single nuclei. Nat Protoc. 2016 Feb; 11(2):214-235. PMID: 26741407; PMCID: PMC4807405.
      Citations: 23     Fields:    Translation:Cells
    61. Navin NE. The first five years of single-cell cancer genomics and beyond. Genome Res. 2015 Oct; 25(10):1499-507. PMID: 26430160; PMCID: PMC4579335.
      Citations: 165     Fields:    Translation:HumansAnimals
    62. Alizadeh AA, Aranda V, Bardelli A, Bock C, Borowski C, Caldas C, Califano A, Doherty M, Elsner M, Esteller M, Fitzgerald R, Korbel JO, Lichter P, Mason CE, Navin N, Pe'er D, Polyak K, Roberts CW, Siu L, Snyder A, Stower H, Swanton C, Verhaak RG, Zenklusen JC, Zuber J, Blanpain C, Zucman-Rossi J. Toward understanding and exploiting tumor heterogeneity. Nat Med. 2015 Aug; 21(8):846-53. PMID: 26248267; PMCID: PMC4785013.
      Citations: 259     Fields:    Translation:Humans
    63. Navin NE. Delineating cancer evolution with single-cell sequencing. Sci Transl Med. 2015 Jul 15; 7(296):296fs29. PMID: 26180099; PMCID: PMC4785805.
      Citations: 17     Fields:    Translation:Humans
    64. Wang Y, Navin NE. Advances and applications of single-cell sequencing technologies. Mol Cell. 2015 May 21; 58(4):598-609. PMID: 26000845; PMCID: PMC4441954.
      Citations: 216     Fields:    Translation:HumansAnimals
    65. Leung ML, Wang Y, Waters J, Navin NE. SNES: single nucleus exome sequencing. Genome Biol. 2015 Mar 25; 16:55. PMID: 25853327; PMCID: PMC4373516.
      Citations: 46     Fields:    Translation:HumansCells
    66. Malhotra A, Wang Y, Waters J, Chen K, Meric-Bernstam F, Hall IM, Navin NE. Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations. Genome Med. 2015; 7(1):6. PMID: 25729435; PMCID: PMC4343275.
      Citations: 5     Fields:    
    67. Navin NE. Cancer genomics: one cell at a time. Genome Biol. 2014 Aug 30; 15(8):452. PMID: 25222669; PMCID: PMC4281948.
      Citations: 131     Fields:    Translation:HumansCells
    68. Wang Y, Waters J, Leung ML, Unruh A, Roh W, Shi X, Chen K, Scheet P, Vattathil S, Liang H, Multani A, Zhang H, Zhao R, Michor F, Meric-Bernstam F, Navin NE. Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature. 2014 Aug 14; 512(7513):155-60. PMID: 25079324; PMCID: PMC4158312.
      Citations: 443     Fields:    Translation:HumansCells
    69. Navin NE. Tumor evolution in response to chemotherapy: phenotype versus genotype. Cell Rep. 2014 Feb 13; 6(3):417-9. PMID: 24529750; PMCID: PMC5558200.
      Citations: 26     Fields:    Translation:Humans
    70. Chen K, Navin NE, Wang Y, Schmidt HK, Wallis JW, Niu B, Fan X, Zhao H, McLellan MD, Hoadley KA, Mardis ER, Ley TJ, Perou CM, Wilson RK, Ding L. BreakTrans: uncovering the genomic architecture of gene fusions. Genome Biol. 2013 Aug 23; 14(8):R87. PMID: 23972288; PMCID: PMC4054677.
      Citations: 13     Fields:    Translation:HumansCells
    71. Baslan T, Kendall J, Rodgers L, Cox H, Riggs M, Stepansky A, Troge J, Ravi K, Esposito D, Lakshmi B, Wigler M, Navin N, Hicks J. Genome-wide copy number analysis of single cells. Nat Protoc. 2012 May 03; 7(6):1024-41. PMID: 22555242; PMCID: PMC5069701.
      Citations: 174     Fields:    Translation:HumansCells
    72. Russnes HG, Navin N, Hicks J, Borresen-Dale AL. Insight into the heterogeneity of breast cancer through next-generation sequencing. J Clin Invest. 2011 Oct; 121(10):3810-8. PMID: 21965338; PMCID: PMC3195464.
      Citations: 104     Fields:    Translation:Humans
    73. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell. 2011 Aug 16; 20(2):173-86. PMID: 21840483; PMCID: PMC3176728.
      Citations: 99     Fields:    Translation:Humans
    74. Blake PM, Decker DA, Glennon TM, Liang YM, Losko S, Navin N, Suh KS. Toward an integrated knowledge environment to support modern oncology. Cancer J. 2011 Jul-Aug; 17(4):257-63. PMID: 21799334.
      Citations: 4     Fields:    Translation:Humans
    75. Navin N, Hicks J. Future medical applications of single-cell sequencing in cancer. Genome Med. 2011 May 31; 3(5):31. PMID: 21631906; PMCID: PMC3219072.
      Citations: 81     Fields:    
    76. Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, Cook K, Stepansky A, Levy D, Esposito D, Muthuswamy L, Krasnitz A, McCombie WR, Hicks J, Wigler M. Tumour evolution inferred by single-cell sequencing. Nature. 2011 Apr 07; 472(7341):90-4. PMID: 21399628; PMCID: PMC4504184.
      Citations: 1123     Fields:    Translation:HumansCells
    77. Navin NE, Hicks J. Tracing the tumor lineage. Mol Oncol. 2010 Jun; 4(3):267-83. PMID: 20537601; PMCID: PMC2904844.
      Citations: 61     Fields:    Translation:Humans
    78. Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, Kendall J, Riggs M, Eberling Y, Troge J, Grubor V, Levy D, Zetterberg A, Hicks J, Wigler M, Lundin P, M?n?r S. Inferring tumor progression from genomic heterogeneity. Genome Res. 2010 Jan; 20(1):68-80. PMID: 19903760; PMCID: PMC2798832.
      Citations: 227     Fields:    Translation:Humans
    79. Grubor V, Krasnitz A, Troge JE, Meth JL, Lakshmi B, Kendall JT, Yamrom B, Alex G, Pai D, Navin N, Hufnagel LA, Lee YH, Cook K, Allen SL, Rai KR, Damle RN, Calissano C, Chiorazzi N, Wigler M, Esposito D. Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). Blood. 2009 Feb 05; 113(6):1294-303. PMID: 18922857.
      Citations: 42     Fields:    Translation:HumansCells
    80. Pelham RJ, Rodgers L, Hall I, Lucito R, Nguyen KC, Navin N, Hicks J, Mu D, Powers S, Wigler M, Botstein D. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19848-53. PMID: 17167050; PMCID: PMC1698871.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    81. Hicks J, Krasnitz A, Lakshmi B, Navin NE, Riggs M, Leibu E, Esposito D, Alexander J, Troge J, Grubor V, Yoon S, Wigler M, Ye K, Schlicting E, Norton L, Skoog L, Auer G, Zetterberg A, B?rresen-Dale AL, Naume B, H?gerstr?m T, M?n?r S, Lundin P. Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Res. 2006 Dec; 16(12):1465-79. PMID: 17142309; PMCID: PMC1665631.
      Citations: 143     Fields:    Translation:Humans
    82. Navin N, Grubor V, Hicks J, Leibu E, Thomas E, Troge J, Riggs M, Sebat J, Zetterberg A, Wigler M, Lundin P, M?n?r S. PROBER: oligonucleotide FISH probe design software. Bioinformatics. 2006 Oct 01; 22(19):2437-8. PMID: 16740623.
      Citations: 17     Fields:    Translation:Cells
    83. Hicks J, Muthuswamy L, Krasnitz A, Navin N, Riggs M, Grubor V, Esposito D, Alexander J, Troge J, Wigler M, Maner S, Lundin P, Zetterberg A. High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors. Cold Spring Harb Symp Quant Biol. 2005; 70:51-63. PMID: 16869738.
      Citations: 5     Fields:    Translation:Humans
    84. Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, Reiner A, Gilliam TC, Trask B, Patterson N, Zetterberg A, Wigler M, Lundin P, M?n?r S. Large-scale copy number polymorphism in the human genome. Science. 2004 Jul 23; 305(5683):525-8. PMID: 15273396.
      Citations: 1000     Fields:    Translation:HumansCells
    85. Thomas EE, Srebro N, Sebat J, Navin N, Healy J, Mishra B, Wigler M. Distribution of short paired duplications in mammalian genomes. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10349-54. PMID: 15240876; PMCID: PMC478600.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    86. Espanel X, Navin N, Kato Y, Tanokura M, Sudol M. Probing WW Domains to Uncover and Refine Determinants of Specificity in Ligand Recognition. Cytotechnology. 2003 Nov; 43(1-3):105-11. PMID: 19003214; PMCID: PMC3449593.
      Citations: 1     Fields:    
    87. Komuro A, Nagai M, Navin NE, Sudol M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem. 2003 Aug 29; 278(35):33334-41. PMID: 12807903.
      Citations: 214     Fields:    Translation:HumansAnimalsCells
    88. Highly multiplexed targeted DNA sequencing from single nuclei. Nature Protocols. 11:214-235.
    89. Genotyping tumor clones from single-cell data. Nature Methods. 13:555-556.
    90. Corrigendum to "Tracing the tumor lineage" [Mol. Oncol. 4 (2010) 267-283]. Molecular Oncology. 5:302.
    91. Single-cell analysis at the threshold. Nature Biotechnology. 34:1111-1118.
    92. Delineating cancer evolution with single-cell sequencing. Science Translational Medicine. 7.
    93. Ploidy-Seq. Genome Medicine. 7.
    94. The first five years of single-cell cancer genomics and beyond. Genome Research. 25:1499-1507.
    95. Genome evolution in ductal carcinoma in situ. Journal of Pathology. 241:208-218.
    96. Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq. Nature Biotechnology. 34:962-972.
    97. Punctuated copy number evolution and clonal stasis in triple-negative breast cancer. Nature Genetics.
    98. Computing tumor trees from single cells. Genome Biology. 17.
    99. Monovar. Nature Methods.
    100. Erratum. Nature Protocols. 11:616.
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