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AMER M NAJJAR

TitleAssistant Professor
InstitutionMD Anderson
DepartmentPediatrics
Address1515 Holcombe Blvd.
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bachiller M, Perez-Amill L, Battram AM, Najjar A, Juan M, Urbano-Ispizua A, Carn? SC, Verhoeyen E, Martin-Antonio B. NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness. J Immunother Cancer. 2021 08; 9(8). PMID: 34433634; PMCID: PMC8388291.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    2. Saberian C, Amaria RN, Najjar AM, Radvanyi LG, Haymaker CL, Bassett RL, Faria SC, Glitza IC, Alvarez E, Parshottam S, Prieto V, Wong MK, McQuade JL, Diab A, Yee C, Tawbi HA, Patel S, Shpall EJ, Davies MA, Hwu P, Bernatchez C, Forget MA, Liz?e G. Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma. J Immunother Cancer. 2021 05; 9(5). PMID: 34021033; PMCID: PMC8144048.
      Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
    3. Perez-Amill L, Castella M, Najjar A, Bonet J, Bueno C, Juan M, Su?e G, Anto?ana-Vildosola A, Fern?ndez-Fuentes N, Inog?s S, L?pez A, Urbano-Ispizua ?, Mart?n-Antonio B. Preclinical development of a humanized chimeric antigen receptor against B cell maturation antigen for multiple myeloma. Haematologica. 2021 01 01; 106(1):173-184. PMID: 31919085; PMCID: PMC7776337.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    4. Hauser PJ, Bandey I, Laskowski T, Wang Q, Najjar AM, Kumaresan PR, da Silva TA. Glucuronoxylomannan in the Cryptococcus species capsule as a target for Chimeric Antigen Receptor T-cell therapy. Cytotherapy. 2021 02; 23(2):119-130. PMID: 33303326.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Najjar AM. Radiolabeling and Imaging of Adoptively Transferred Immune Cells by Positron Emission Tomography. Methods Mol Biol. 2020; 2097:267-272. PMID: 31776932.
      Citations: 2     Fields:    Translation:Animals
    6. Najjar AM, Johnson JM, Schellingerhout D. The Emerging Role of Amino Acid PET in Neuro-Oncology. Bioengineering (Basel). 2018 Nov 28; 5(4). PMID: 30487391; PMCID: PMC6315339.
      Citations: 9     
    7. Najjar AM, Manuri PR, Olivares S, Flores L, Mi T, Huls H, Shpall EJ, Champlin RE, Turkman N, Paolillo V, Roszik J, Rabinovich B, Lee DA, Alauddin M, Gelovani J, Cooper LJ. Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography. Mol Imaging Biol. 2016 12; 18(6):838-848. PMID: 27246312; PMCID: PMC5096958.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    8. Hurton LV, Singh H, Najjar AM, Switzer KC, Mi T, Maiti S, Olivares S, Rabinovich B, Huls H, Datar V, Kebriaei P, Lee DA, Champlin RE, Cooper LJ, Forget MA. Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7788-E7797. PMID: 27849617; PMCID: PMC5137758.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    9. Torikai H, Mi T, Gragert L, Maiers M, Najjar A, Ang S, Maiti S, Dai J, Switzer KC, Huls H, Dulay GP, Reik A, Rebar EJ, Holmes MC, Gregory PD, Champlin RE, Shpall EJ, Cooper LJ. Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application. Sci Rep. 2016 Feb 23; 6:21757. PMID: 26902653; PMCID: PMC4763194.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    10. Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, Olivares S, Mi T, Switzer K, Singh H, Huls H, Lee DA, Heimberger AB, Champlin RE, Cooper LJ. Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity. Cancer Res. 2015 Sep 01; 75(17):3505-18. PMID: 26330164; PMCID: PMC4624228.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    11. Bonomi R, Mukhopadhyay U, Shavrin A, Yeh HH, Majhi A, Dewage SW, Najjar A, Lu X, Tong WP, Alauddin MM, Liu RS, Mangner TJ, Turkman N, Gelovani JG, Cisneros GA. Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain. PLoS One. 2015; 10(8):e0133512. PMID: 26244761; PMCID: PMC4526562.
      Citations: 11     Fields:    Translation:Animals
    12. Parmar S, Liu X, Najjar A, Shah N, Yang H, Yvon E, Rezvani K, McNiece I, Zweidler-McKay P, Miller L, Wolpe S, Blazar BR, Shpall EJ. Ex vivo fucosylation of third-party human regulatory T cells enhances anti-graft-versus-host disease potency in vivo. Blood. 2015 Feb 26; 125(9):1502-6. PMID: 25428215; PMCID: PMC4342362.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    13. Parmar S, Liu X, Tung SS, Robinson SN, Rodriguez G, Cooper LJ, Yang H, Shah N, Yang H, Konopleva M, Molldrem JJ, Garcia-Manero G, Najjar A, Yvon E, McNiece I, Rezvani K, Savoldo B, Bollard CM, Shpall EJ. Third-party umbilical cord blood-derived regulatory T cells prevent xenogenic graft-versus-host disease. Cytotherapy. 2014 Jan; 16(1):90-100. PMID: 24480547; PMCID: PMC4124936.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    14. Shah N, Martin-Antonio B, Yang H, Ku S, Lee DA, Cooper LJ, Decker WK, Li S, Robinson SN, Sekine T, Parmar S, Gribben J, Wang M, Rezvani K, Yvon E, Najjar A, Burks J, Kaur I, Champlin RE, Bollard CM, Shpall EJ. Antigen presenting cell-mediated expansion of human umbilical cord blood yields log-scale expansion of natural killer cells with anti-myeloma activity. PLoS One. 2013; 8(10):e76781. PMID: 24204673; PMCID: PMC3800010.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    15. Robinson SN, Thomas MW, Simmons PJ, Lu J, Yang H, Parmar S, Liu X, Shah N, Bollard C, Dotti G, Savoldo B, Cooper LJ, Najjar A, Rezvani K, Kaur I, McNiece IK, Champlin RE, Miller LP, Zweidler-McKay PA, Shpall EJ, Mart?n-Antonio B. Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment. Cytotherapy. 2014 Jan; 16(1):84-9. PMID: 24094497; PMCID: PMC3883688.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Wang J, Najjar A, Zhang S, Rabinovich B, Willerson JT, Gelovani JG, Yeh ET. Molecular imaging of mesenchymal stem cell: mechanistic insight into cardiac repair after experimental myocardial infarction. Circ Cardiovasc Imaging. 2012 Jan; 5(1):94-101. PMID: 22135400; PMCID: PMC3273544.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    17. Perin EC, Tian M, Marini FC, Silva GV, Zheng Y, Baimbridge F, Quan X, Fernandes MR, Gahremanpour A, Young D, Paolillo V, Mukhopadhyay U, Borne AT, Uthamanthil R, Brammer D, Jackson J, Decker WK, Najjar AM, Thomas MW, Volgin A, Rabinovich B, Soghomonyan S, Jeong HJ, Rios JM, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Willerson JT, Shpall E, Gelovani JG. Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model. PLoS One. 2011; 6(9):e22949. PMID: 21912635; PMCID: PMC3164664.
      Citations: 23     Fields:    Translation:AnimalsCells
    18. Yeh HH, Ogawa K, Balatoni J, Mukhapadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1603-8. PMID: 21220318; PMCID: PMC3029752.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    19. Steiner D, Gelovani J, Savoldo B, Robinson SN, Decker WK, Brouard N, Najjar A, Xing D, Yang H, Li S, Marini F, Zweidler-McKay PA, Bollard CM, Shpall EJ, Dotti G, Simmons PJ. Noninvasive bioluminescent imaging demonstrates long-term multilineage engraftment of ex vivo-expanded CD34-selected umbilical cord blood cells. Stem Cells. 2009 Aug; 27(8):1932-40. PMID: 19544439; PMCID: PMC3348864.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Dotti G, Tian M, Savoldo B, Najjar A, Cooper LJ, Jackson J, Smith A, Mawlawi O, Uthamanthil R, Borne A, Brammer D, Paolillo V, Alauddin M, Gonzalez C, Steiner D, Decker WK, Marini F, Kornblau S, Bollard CM, Shpall EJ, Gelovani JG. Repetitive noninvasive monitoring of HSV1-tk-expressing T cells intravenously infused into nonhuman primates using positron emission tomography and computed tomography with 18F-FEAU. Mol Imaging. 2009 Jul-Aug; 8(4):230-7. PMID: 19728977; PMCID: PMC3178066.
      Citations: 15     Fields:    Translation:AnimalsCells
    21. Najjar AM, Nishii R, Maxwell DS, Volgin A, Mukhopadhyay U, Bornmann WG, Tong W, Alauddin M, Gelovani JG. Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs. J Nucl Med. 2009 Mar; 50(3):409-16. PMID: 19223410.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Park SI, Zhang J, Phillips KA, Araujo JC, Najjar AM, Volgin AY, Gelovani JG, Kim SJ, Wang Z, Gallick GE. Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res. 2008 May 01; 68(9):3323-33. PMID: 18451159.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    23. de Lima MJ, Thomas E, Khanna A, Najjar AM, Gu J, Gelovani JG, Broaddus R, K?rbling M. Fusion of circulating blood cells with solid-organ tissue cells in clinical stem cell transplants: a potential therapeutic model? Regen Med. 2008 Mar; 3(2):157-64. PMID: 18307399.
      Citations:    Fields:    Translation:Humans
    24. DNA Plasmids for Non-viral Gene Therapy of Cancer. 39-59.
    25. Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography. Molecular Imaging and Biology. 1-11.
    26. Validation of a dual reporter system for in vivo heat-mediated HSP70 expression in prostate tumors.
    27. Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application. Scientific Reports. 6.
    28. Novel histone deacetylase class IIa selective substrate radiotracers for PET imaging of epigenetic regulation in the brain. PLoS One. 10.
    29. Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells. Proceedings of the National Academy of Sciences of the United States of America. 113:E7788-E7797.
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