LISA SCHENLISA S CHEN9204CHEN, LISA SAssistant Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson1901 East RoadHouston77054-3005TXAuthorship 181516119477165Chen LS, Nowak BJ, Ayres ML, Krett NL, Rosen ST, Zhang S, Gandhi VBiochemical pharmacologyInhibition of ATP synthase by chlorinated adenosine analogue. Biochem Pharmacol. 2009 Sep 15; 78(6):583-91.Biochem Pharmacol2009-05-27T00:00:002009Inhibition of ATP synthase by chlorinated adenosine analogue.Experimental TherapeuticsLeukemiaMD AndersonVARSHA VGANDHIVARSHA V GANDHI8582GANDHI, VARSHA VProfessorJORGE ECORTESJORGE E CORTES8637CORTES, JORGE EProfessorWILLIAM GWIERDAWILLIAM G WIERDA8937WIERDA, WILLIAM GProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorKUMUDHABALAKRISHNANKUMUDHA BALAKRISHNAN9028BALAKRISHNAN, KUMUDHAAssociate Professor1.344950.00686998103research areas3.030260.02733939coauthor of33.47412.3528960similar to1118selected publicationsELIAS JOSEPHJABBOURELIAS JOSEPH JABBOUR9124JABBOUR, ELIAS JOSEPHAssociate ProfessorSHUXINGZHANGSHUXING ZHANG9396ZHANG, SHUXINGAssociate ProfessorAuthorship 2195141Authorship 2202221Authorship 2320922Authorship 234777212484453Chen LS, Sheppard TLNucleosides, nucleotides & nucleic acidsSynthesis and hybridization properties of RNA containing 8-chloroadenosine. Nucleosides Nucleotides Nucleic Acids. 2002; 21(8-9):599-617.Nucleosides Nucleotides Nucleic Acids2002-01-01T00:00:002002Synthesis and hybridization properties of RNA containing 8-chloroadenosine.12699743Chen LS, Bahr MH, Sheppard TLBioorganic & medicinal chemistry lettersEffects of 8-chlorodeoxyadenosine on DNA synthesis by the Klenow fragment of DNA polymerase I. Bioorg Med Chem Lett. 2003 May 05; 13(9):1509-12.Bioorg Med Chem Lett2003-05-05T00:00:002003Effects of 8-chlorodeoxyadenosine on DNA synthesis by the Klenow fragment of DNA polymerase I.22448923Pillai RN, Chen LS, Ayres ML, Nowak BJ, Thomas MW, Shpall EJ, Keating MJ, Gandhi VLeukemia & lymphomaMultifaceted actions of 8-amino-adenosine kill BCR-ABL positive cells. Leuk Lymphoma. 2012 Oct; 53(10):2024-32.Leuk Lymphoma2012-04-23T00:00:002012Multifaceted actions of 8-amino-adenosine kill BCR-ABL positive cells.23988451Cervantes-Gomez F, Chen LS, Orlowski RZ, Gandhi VClinical lymphoma, myeloma & leukemiaBiological effects of the Pim kinase inhibitor, SGI-1776, in multiple myeloma. Clin Lymphoma Myeloma Leuk. 2013 Sep; 13 Suppl 2:S317-29.Clin Lymphoma Myeloma Leuk2013-08-27T00:00:002013Biological effects of the Pim kinase inhibitor, SGI-1776, in multiple myeloma.Authorship 2501491Authorship 2520073Authorship 2534851Authorship 2542291Authorship 2545892Authorship 255825118205859Chen LS, Stellrecht CM, Gandhi VBritish journal of haematologyRNA-directed agent, cordycepin, induces cell death in multiple myeloma cells. Br J Haematol. 2008 Mar; 140(6):682-391.Br J Haematol2008-01-18T00:00:002008RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells.18948586Gandhi V, Balakrishnan K, Chen LSBloodMcl-1: the 1 in CLL. Blood. 2008 Nov 01; 112(9):3538-40.Blood2008-11-01T00:00:002008Mcl-1: the 1 in CLL.19734450Chen LS, Redkar S, Bearss D, Wierda WG, Gandhi VBloodPim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood. 2009 Nov 05; 114(19):4150-7.Blood2009-09-04T00:00:002009Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.20428111Zhang S, Chen L, Jung EJ, Calin GAClinical pharmacology and therapeuticsTargeting microRNAs with small molecules: from dream to reality. Clin Pharmacol Ther. 2010 Jun; 87(6):754-8.Clin Pharmacol Ther2010-04-28T00:00:002010Targeting microRNAs with small molecules: from dream to reality.20696142Chen LS, Balakrishnan K, Gandhi VBiochemical pharmacologyInflammation and survival pathways: chronic lymphocytic leukemia as a model system. Biochem Pharmacol. 2010 Dec 15; 80(12):1936-45.Biochem Pharmacol2010-08-07T00:00:002010Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.21628411Chen LS, Redkar S, Taverna P, Cortes JE, Gandhi VBloodMechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood. 2011 Jul 21; 118(3):693-702.Blood2011-05-31T00:00:002011Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.Authorship 266462115265873Chen LS, Sheppard TLThe Journal of biological chemistryChain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J Biol Chem. 2004 Sep 24; 279(39):40405-11.J Biol Chem2004-07-19T00:00:002004Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs.Authorship 273437119814999Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi VBiochemical pharmacologyChain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol. 2010 Mar 01; 79(5):669-77.Biochem Pharmacol2009-10-06T00:00:002009Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.23837491Patel V, Chen LS, Wierda WG, Balakrishnan K, Gandhi VLeukemia & lymphomaImpact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia. Leuk Lymphoma. 2014 Apr; 55(4):899-910.Leuk Lymphoma2013-09-10T00:00:002013Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia.25341939Yang Q, Chen LS, Gandhi VCurrent pharmaceutical designMechanism-based combinations with Pim kinase inhibitors in cancer treatments. Curr Pharm Des. 2014; 20(42):6670-81.Curr Pharm Des2014-01-01T00:00:002014Mechanism-based combinations with Pim kinase inhibitors in cancer treatments.74Professor10Assistant Professor14Associate ProfessorAuthorship 3745472Authorship 3745502Authorship 843165Authorship 852678Authorship 863003Leukemia and LymphomaProtein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia. Leukemia and Lymphoma. 1-11.Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemiaInorganica Chimica ActaSynthesis, characterization, redox properties, and representative X-ray structures of four- and five-coordinate copper(II) complexes with polydentate aminopyridine ligands. Inorganica Chimica Acta. 324:1-15.Synthesis, characterization, redox properties, and representative X-ray structures of four- and five-coordinate copper(II) complexes with polydentate aminopyridine ligandsPim kinases in aml. 177-199.Pim kinases in amlD015762Chemicals & Drugs16370.966152-ChloroadenosineD051573Chemicals & Drugs26450.95592Proto-Oncogene Proteins c-pim-1D007093Chemicals & Drugs42010050.643336ImidazolesD011724Chemicals & Drugs912930.794774PyridazinesD011062Chemicals & Drugs7100.989575Polynucleotide Adenylyltransferasetrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professor