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SAID AKLI

TitleAssistant Professor
InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lulla AR, Akli S, Karakas C, Caruso JA, Warma LD, Fowlkes NW, Rao X, Wang J, Hunt KK, Watowich SS, Keyomarsi K. Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis. Mol Cancer Ther. 2024 Apr 02; 23(4):492-506. PMID: 37796181; PMCID: PMC10987287.
      Citations: 1     Fields:    
    2. Lulla AR, Akli S, Karakas C, Ha MJ, Fowlkes NW, Mitani Y, Bui T, Wang J, Rao X, Hunt KK, Meijer L, El-Naggar AK, Keyomarsi K. LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers. Oncogenesis. 2021 May 14; 10(5):40. PMID: 33990543; PMCID: PMC8121779.
      Citations:    
    3. Karakas C, Biernacka A, Bui T, Sahin AA, Yi M, Akli S, Schafer J, Alexander A, Adjapong O, Hunt KK, Keyomarsi K. Cytoplasmic Cyclin E and Phospho-Cyclin-Dependent Kinase 2 Are Biomarkers of Aggressive Breast Cancer. Am J Pathol. 2016 07; 186(7):1900-1912. PMID: 27182644; PMCID: PMC4929404.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    4. Caruso JA, Akli S, Pageon L, Hunt KK, Keyomarsi K. The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase. Oncogene. 2015 Jul; 34(27):3556-67. PMID: 25195861; PMCID: PMC4362782.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    5. Duong MT, Akli S, Macalou S, Biernacka A, Debeb BG, Yi M, Hunt KK, Keyomarsi K. Hbo1 is a cyclin E/CDK2 substrate that enriches breast cancer stem-like cells. Cancer Res. 2013 Sep 01; 73(17):5556-68. PMID: 23955388; PMCID: PMC3773499.
      Citations: 21     Fields:    Translation:HumansCells
    6. Akli S, Zhang XQ, Bondaruk J, Tucker SL, Czerniak PB, Benedict WF, Keyomarsi K. Low molecular weight cyclin E is associated with p27-resistant, high-grade, high-stage and invasive bladder cancer. Cell Cycle. 2012 Apr 01; 11(7):1468-76. PMID: 22441703; PMCID: PMC3350882.
      Citations: 13     Fields:    Translation:HumansCells
    7. Duong MT, Akli S, Wei C, Wingate HF, Liu W, Lu Y, Yi M, Mills GB, Hunt KK, Keyomarsi K. LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients. PLoS Genet. 2012; 8(3):e1002538. PMID: 22479189; PMCID: PMC3315462.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    8. Akli S, Van Pelt CS, Bui T, Meijer L, Keyomarsi K. Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E. Cancer Res. 2011 May 01; 71(9):3377-86. PMID: 21385896; PMCID: PMC3085722.
      Citations: 24     Fields:    Translation:HumansAnimals
    9. Mittendorf EA, Liu Y, Tucker SL, McKenzie T, Qiao N, Akli S, Biernacka A, Meijer L, Keyomarsi K, Hunt KK. A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene. 2010 Jul 08; 29(27):3896-907. PMID: 20453888; PMCID: PMC2900397.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    10. Akli S, Bui T, Wingate H, Biernacka A, Moulder S, Tucker SL, Hunt KK, Keyomarsi K. Low-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors. Clin Cancer Res. 2010 Feb 15; 16(4):1179-90. PMID: 20145171; PMCID: PMC2822889.
      Citations: 24     Fields:    Translation:HumansCells
    11. Akli S, Van Pelt CS, Bui T, Multani AS, Chang S, Johnson D, Tucker S, Keyomarsi K. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res. 2007 Aug 01; 67(15):7212-22. PMID: 17671189.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    12. Barton MC, Akli S, Keyomarsi K. Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer. J Cell Physiol. 2006 Dec; 209(3):686-94. PMID: 17001684.
      Citations: 7     Fields:    Translation:HumansAnimals
    13. Akli S, Keyomarsi K. Low-molecular-weight cyclin E: the missing link between biology and clinical outcome. Breast Cancer Res. 2004; 6(5):188-91. PMID: 15318923; PMCID: PMC549170.
      Citations: 10     Fields:    Translation:AnimalsCells
    14. Akli S, Zheng PJ, Multani AS, Wingate HF, Pathak S, Zhang N, Tucker SL, Chang S, Keyomarsi K. Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res. 2004 May 01; 64(9):3198-208. PMID: 15126360.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    15. Wingate H, Bedrosian I, Akli S, Keyomarsi K. The low molecular weight (LMW) isoforms of cyclin E deregulate the cell cycle of mammary epithelial cells. Cell Cycle. 2003 Sep-Oct; 2(5):461-6. PMID: 12963845.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    16. Akli S, Keyomarsi K. Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy. Cancer Biol Ther. 2003 Jul-Aug; 2(4 Suppl 1):S38-47. PMID: 14508079.
      Citations: 30     Fields:    Translation:HumansCells
    17. Akli S, Zhan S, Abdellatif M, Schneider MD. E1A can provoke G1 exit that is refractory to p21 and independent of activating cdk2. Circ Res. 1999 Aug 20; 85(4):319-28. PMID: 10455060.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. Guidotti J, Akli S, Castelnau-Ptakhine L, Kahn A, Poenaru L, Guidotti J. Retrovirus-mediated enzymatic correction of Tay-Sachs defect in transduced and non-transduced cells. Hum Mol Genet. 1998 May; 7(5):831-8. PMID: 9536087.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    19. Lisovoski F, Akli S, Peltekian E, Vigne E, Haase G, Perricaudet M, Dreyfus PA, Kahn A, Peschanski M, Lisovoski F. Phenotypic alteration of astrocytes induced by ciliary neurotrophic factor in the intact adult brain, As revealed by adenovirus-mediated gene transfer. J Neurosci. 1997 Oct 01; 17(19):7228-36. PMID: 9295369; PMCID: PMC6573439.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Haase G, Kennel P, Pettmann B, Vigne E, Akli S, Revah F, Schmalbruch H, Kahn A, Haase G. Gene therapy of murine motor neuron disease using adenoviral vectors for neurotrophic factors. Nat Med. 1997 Apr; 3(4):429-36. PMID: 9095177.
      Citations: 40     Fields:    Translation:AnimalsCells
    21. Akli S, Guidotti JE, Vigne E, Perricaudet M, Sandhoff K, Kahn A, Poenaru L, Akli S. Restoration of hexosaminidase A activity in human Tay-Sachs fibroblasts via adenoviral vector-mediated gene transfer. Gene Ther. 1996 Sep; 3(9):769-74. PMID: 8875224.
      Citations: 5     Fields:    Translation:HumansCells
    22. Kahn A, Haase G, Akli S, Guidotti JE, Kahn A. [Gene therapy of neurological diseases]. C R Seances Soc Biol Fil. 1996; 190(1):9-11. PMID: 8881264.
      Citations:    Fields:    Translation:AnimalsCells
    23. Cohen-Tannoudji M, Marchand P, Akli S, Sheardown SA, Puech JP, Kress C, Gressens P, Nassogne MC, Beccari T, Muggleton-Harris AL, Cohen-Tannoudji M, et al. Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease. Mamm Genome. 1995 Dec; 6(12):844-9. PMID: 8747922.
      Citations: 11     Fields:    Translation:AnimalsCells
    24. Lisovoski F, Peltekian E, Akli S, Vigne E, Bouchard C, Haase G, Dreyfus P, Perricaudet M, Kahn A, Peschanski M, Lisovoski F. Using adenoviral vectors to transfer the CNTF gene into the CNS. Restor Neurol Neurosci. 1995 Jan 01; 8(1):45-6. PMID: 21551805.
      Citations:    Fields:    
    25. Lisovoski F, Cadusseau J, Akli S, Caillaud C, Vigne E, Poenaru L, Stratford-Perricaudet L, Pericaudet M, Kahn A, Peschanski M, Lisovoski F. In vivo transfer of a marker gene to study motoneuronal development. Neuroreport. 1994 May 09; 5(9):1069-72. PMID: 8080960.
      Citations: 3     Fields:    Translation:AnimalsCells
    26. Poenaru L, Akli S, Poenaru L. Molecular epidemiology of Tay-Sachs disease in Europe. Biomed Pharmacother. 1994; 48(8-9):341-6. PMID: 7858168.
      Citations:    Fields:    Translation:HumansCells
    27. Caillaud C, Akli S, Vigne E, Koulakoff A, Perricaudet M, Poenaru L, Kahn A, Berwald-Netter Y, Caillaud C. Adenoviral vector as a gene delivery system into cultured rat neuronal and glial cells. Eur J Neurosci. 1993 Oct 01; 5(10):1287-91. PMID: 8275231.
      Citations: 9     Translation:AnimalsCells
    28. Peschanski M, Lisovoski F, Akli S, Caillaud C, Wahrman P, Weber-Benarous A, Vigne E, Stratford-Perricaudet L, Perricaudet M, Kahn A, Peschanski M. [Gene transfer with a therapeutic purpose in the central nervous system]. Nouv Rev Fr Hematol (1978). 1993 Jun; 35(3):299-300. PMID: 8337147.
      Citations:    Fields:    Translation:Humans
    29. Akli S, Caillaud C, Vigne E, Stratford-Perricaudet LD, Poenaru L, Perricaudet M, Kahn A, Peschanski MR, Akli S. Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet. 1993 Mar; 3(3):224-8. PMID: 8485577.
      Citations: 68     Fields:    Translation:AnimalsCells
    30. Akli S, Chelly J, Kahn A, Poenaru L, Akli S. A null allele frequent in non-Jewish Tay-Sachs patients. Hum Genet. 1993 Feb; 90(6):614-20. PMID: 8444467.
      Citations: 3     Fields:    Translation:HumansCells
    31. Akli S, Boue J, Sandhoff K, Kleijer W, Vamos E, Young E, Gatti R, Di Natale P, Motte J, Vanier MT, Akli S, et al. Collaborative study of the molecular epidemiology of Tay-Sachs disease in Europe. Eur J Hum Genet. 1993; 1(3):229-38. PMID: 8044648.
      Citations: 5     Fields:    Translation:HumansCells
    32. Akli S, Chomel JC, Lacorte JM, Bachner L, Kahn A, Poenaru L, Akli S. Ten novel mutations in the HEXA gene in non-Jewish Tay-Sachs patients. Hum Mol Genet. 1993 Jan; 2(1):61-7. PMID: 8490625.
      Citations: 17     Fields:    Translation:HumansCells
    33. Poenaru L, Akli S, Rocchiccioli F, Eydoux P, Zamet P, Poenaru L. Human beta-mannosidosis: a 3-year-old boy with speech impairment and emotional instability. Clin Genet. 1992 Jun; 41(6):331-4. PMID: 1623631.
      Citations: 8     Fields:    Translation:Humans
    34. Chelly J, Gilgenkrantz H, Hugnot JP, Hamard G, Lambert M, Récan D, Akli S, Cometto M, Kahn A, Kaplan JC, Chelly J, R?can D. Illegitimate transcription. Application to the analysis of truncated transcripts of the dystrophin gene in nonmuscle cultured cells from Duchenne and Becker patients. J Clin Invest. 1991 Oct; 88(4):1161-6. PMID: 1918370; PMCID: PMC295575.
      Citations: 17     Fields:    Translation:HumansCells
    35. Akli S, Chelly J, Lacorte JM, Poenaru L, Kahn A, Akli S. Seven novel Tay-Sachs mutations detected by chemical mismatch cleavage of PCR-amplified cDNA fragments. Genomics. 1991 Sep; 11(1):124-34. PMID: 1837283.
      Citations: 35     Fields:    Translation:HumansCells
    36. Akli S, Chelly J, Mezard C, Gandy S, Kahn A, Poenaru L, Akli S. A "G" to "A" mutation at position -1 of a 5' splice site in a late infantile form of Tay-Sachs disease. J Biol Chem. 1990 May 05; 265(13):7324-30. PMID: 2139660.
      Citations: 18     Fields:    Translation:HumansCells
    37. Poenaru L, Mezard C, Akli S, Oury JF, Dumez Y, Boue J. Prenatal diagnosis of mucolipidosis type II on first-trimester amniotic fluid. Prenat Diagn. 1990 Apr; 10(4):231-5. PMID: 1973293.
      Citations:    Fields:    Translation:Humans
    38. Gandy S, Castelnau L, Akli S, Kahn A, Poenaru L, Gandy S. Msp1 RFLP in the human hexosaminidase beta peptide (Hex B) gene. Nucleic Acids Res. 1989 Aug 25; 17(16):6761. PMID: 2476722; PMCID: PMC318399.
      Citations:    Fields:    Translation:HumansCells
    39. Poenaru L, Castelnau L, Besançon AM, Nicolesco H, Akli S, Theophil D, Besan?on AM. First trimester prenatal diagnosis of metachromatic leukodystrophy on chorionic villi by 'immunoprecipitation-electrophoresis'. J Inherit Metab Dis. 1988; 11(2):123-30. PMID: 2902245.
      Citations: 3     Fields:    Translation:HumansCells
    40. Erratum. Human Molecular Genetics. 2:496.
    41. Using adenoviral vectors to transfer the CNTF gene into the CNS. Restorative Neurology and Neuroscience. 8:45-46.
    42. The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase. Oncogene. 34:3556-3567.
    43. MALADIES DE TAY-SACHS ET DE SANDHOFF. Medecine/Sciences. 8:797-804.
    44. PCRBASE. Medecine/Sciences. 9:1256-1261.
    45. L'ADENOVIRUS. Medecine/Sciences. 9:236-237.
    46. Ten novel mutations in the HEXA gene in non-jewish tay-sachs patients. Human Molecular Genetics. 2:496.
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