WEIGUOZHANGWEIGUO ZHANG8852ZHANG, WEIGUOAssistant Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson1515 Holcombe BlvdHouston77030-4009TXAuthorship 1669435Authorship 1681782Authorship 1710822Authorship 1721262Authorship 1792105Authorship 1797291Authorship 1863913Authorship 1873902Authorship 19044269539200Chen J, Aufdemorte TB, Jiang H, Liu AR, Zhang W, Thomas HFThe Histochemical journalNeoplastic odontogenic epithelial cells express bone sialoprotein. Histochem J. 1998 Jan; 30(1):1-6.Histochem J1998-01-01T00:00:001998Neoplastic odontogenic epithelial cells express bone sialoprotein.10571655Li D, Zhang W, Sahin AA, Hittelman WNCancer detection and preventionDNA adducts in normal tissue adjacent to breast cancer: a review. Cancer Detect Prev. 1999; 23(6):454-62.Cancer Detect Prev1999-01-01T00:00:001999DNA adducts in normal tissue adjacent to breast cancer: a review.12576872Abraham S, Zhang W, Greenberg N, Zhang MThe Journal of urologyMaspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells. J Urol. 2003 Mar; 169(3):1157-61.J Urol2003-03-01T00:00:002003Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells.15357246Saku T, Cheng J, Jen KY, Tokunaga M, Li J, Zhang W, Liu A, Wu L, Lu Y, Zhou Z, Li Y, Li R, Ouyang J, Yang L, Yu S, Lou T, Wang S, Lin D, Rao H, Lin H, Sderk P, Chen Z, Chen Z, Cai C, Kim H, Hong SArkhiv patologiiEpstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: a clinicopathologic study of 160 cases. Arkh Patol. 2003 Mar-Apr; 65(2):35-9.Arkh Patol2003-03-01T00:00:002003Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: a clinicopathologic study of 160 cases.21423157Wen J, Fu J, Zhang W, Guo MModern pathology : an official journal of the United States and Canadian Academy of Pathology, IncGenetic and epigenetic changes in lung carcinoma and their clinical implications. Mod Pathol. 2011 Jul; 24(7):932-43.Mod Pathol2011-03-18T00:00:002011Genetic and epigenetic changes in lung carcinoma and their clinical implications.LeukemiaMD AndersonJORGE ECORTESJORGE E CORTES8637CORTES, JORGE EProfessorGAUTAMBORTHAKURGAUTAM BORTHAKUR9181BORTHAKUR, GAUTAMAssociate ProfessorMICHAELANDREEFFMICHAEL ANDREEFF8437ANDREEFF, MICHAELProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessor0.7513890.00543675247research areas2.200370.010868131coauthor of46.37744.9883760similar to1128selected publicationsMARINAKONOPLEVAMARINA KONOPLEVA8702KONOPLEVA, MARINAProfessorFARHADRAVANDI-KASHANIFARHAD RAVANDI-KASHANI8745RAVANDI-KASHANI, FARHADProfessorGUILLERMOGARCIA-MANEROGUILLERMO GARCIA-MANERO8853GARCIA-MANERO, GUILLERMOProfessorAuthorship 2191795Authorship 2229581Authorship 230232912406304Ohtak? S, Cheng J, Ida H, Suzuki M, Ohshiro K, Zhang W, Saku TJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyPrecancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med. 2002 Nov; 31(10):590-7.J Oral Pathol Med2002-11-01T00:00:002002Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry.15907209Zhang W, Shi HY, Zhang MBMC cancerMaspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins. BMC Cancer. 2005 May 20; 5:50.BMC Cancer2005-05-20T00:00:002005Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins.21209776Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks J, Clise-Dwyer K, Wang RY, Zhang W, Yuan X, Lu H, Caldwell L, Andreeff MCancer microenvironment : official journal of the International Cancer Microenvironment SocietyMesenchymal Stem Cells Overexpressing IFN-? Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron. 2010 Mar 19; 3(1):83-95.Cancer Microenviron2010-03-19T00:00:002010Mesenchymal Stem Cells Overexpressing IFN-? Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model.Authorship 2435941Authorship 2473122Authorship 2475292Authorship 2476131Authorship 2516729Authorship 2521254Authorship 2535321Authorship 259240512011991Zhang W, Zhang MInternational journal of oncologyTissue microarray analysis of maspin expression and its reverse correlation with mutant p53 in various tumors. Int J Oncol. 2002 Jun; 20(6):1145-50.Int J Oncol2002-06-01T00:00:002002Tissue microarray analysis of maspin expression and its reverse correlation with mutant p53 in various tumors.15713631Latha K, Zhang W, Cella N, Shi HY, Zhang MMolecular and cellular biologyMaspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition. Mol Cell Biol. 2005 Mar; 25(5):1737-48.Mol Cell Biol2005-03-01T00:00:002005Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition.16151469Zhang W, McQueen T, Schober W, Rassidakis G, Andreeff M, Konopleva MLeukemiaLeukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation. Leukemia. 2005 Nov; 19(11):1977-84.Leukemia2005-11-01T00:00:002005Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation.16505105Konopleva M, Zhang W, Shi YX, McQueen T, Tsao T, Abdelrahim M, Munsell MF, Johansen M, Yu D, Madden T, Safe SH, Hung MC, Andreeff MMolecular cancer therapeuticsSynthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Mol Cancer Ther. 2006 Feb; 5(2):317-28.Mol Cancer Ther2006-02-01T00:00:002006Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.17994624Cui L, Wang Y, Shi Y, Zhang Z, Xia Y, Sun H, Wang S, Chen J, Zhang W, Lu Q, Song L, Wei Q, Zhang R, Wang XProteomicsOverexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer. Proteomics. 2007 Nov; 7(22):4192-202.Proteomics2007-11-01T00:00:002007Overexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer.19052971Mori S, Cortes J, Kantarjian H, Zhang W, Andreef M, Ravandi FLeukemia & lymphomaPotential role of sorafenib in the treatment of acute myeloid leukemia. Leuk Lymphoma. 2008 Dec; 49(12):2246-55.Leuk Lymphoma2008-12-01T00:00:002008Potential role of sorafenib in the treatment of acute myeloid leukemia.20215498Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff MCancer researchBlockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res. 2010 Mar 15; 70(6):2424-34.Cancer Res2010-03-09T00:00:002010Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.23484027Ling X, Spaeth E, Chen Y, Shi Y, Zhang W, Schober W, Hail N, Konopleva M, Andreeff MPloS oneThe CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo. PLoS One. 2013; 8(3):e58426.PLoS One2013-03-06T00:00:002013The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo.Authorship 2725963Authorship 2741924Authorship 2772852Authorship 277845111831972Zhu P, Zhang WZhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology[The role of matrix vesicles during development of the mineralizing tissues of tooth germ and craniofacial bone]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2000 Jan; 35(1):69-71.Zhonghua Kou Qiang Yi Xue Za Zhi2000-01-01T00:00:002000[The role of matrix vesicles during development of the mineralizing tissues of tooth germ and craniofacial bone].16585200Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva MCancer researchSimultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia. Cancer Res. 2006 Apr 01; 66(7):3737-46.Cancer Res2006-04-01T00:00:002006Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.18230792Zhang W, Konopleva M, Shi YX, McQueen T, Harris D, Ling X, Estrov Z, Quint?s-Cardama A, Small D, Cortes J, Andreeff MJournal of the National Cancer InstituteMutant FLT3: a direct target of sorafenib in acute myelogenous leukemia. J Natl Cancer Inst. 2008 Feb 06; 100(3):184-98.J Natl Cancer Inst2008-01-29T00:00:002008Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia.20952518Borthakur G, Kantarjian H, Ravandi F, Zhang W, Konopleva M, Wright JJ, Faderl S, Verstovsek S, Mathews S, Andreeff M, Cortes JEHaematologicaPhase I study of sorafenib in patients with refractory or relapsed acute leukemias. Haematologica. 2011 Jan; 96(1):62-8.Haematologica2010-10-15T00:00:002010Phase I study of sorafenib in patients with refractory or relapsed acute leukemias.24619500Zhang W, Gao C, Konopleva M, Chen Y, Jacamo RO, Borthakur G, Cortes JE, Ravandi F, Ramachandran A, Andreeff MClinical cancer research : an official journal of the American Association for Cancer ResearchReversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. Clin Cancer Res. 2014 May 01; 20(9):2363-74.Clin Cancer Res2014-03-11T00:00:002014Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.11559574Shi HY, Zhang W, Liang R, Abraham S, Kittrell FS, Medina D, Zhang MCancer researchBlocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model. Cancer Res. 2001 Sep 15; 61(18):6945-51.Cancer Res2001-09-15T00:00:002001Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model.74Professor10Assistant Professor14Associate Professor16873551Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SLProceedings of the National Academy of Sciences of the United States of AmericaMice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12179-84.Proc Natl Acad Sci U S A2006-07-27T00:00:002006Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.12507299Shi HY, Zhang W, Liang R, Kittrell F, Templeton NS, Medina D, Zhang MHistology and histopathologyModeling human breast cancer metastasis in mice: maspin as a paradigm. Histol Histopathol. 2003 01; 18(1):201-6.Histol Histopathol2003-01-01T00:00:002003Modeling human breast cancer metastasis in mice: maspin as a paradigm.18200035Zhang W, Konopleva M, Ruvolo VR, McQueen T, Evans RL, Bornmann WG, McCubrey J, Cortes J, Andreeff MLeukemiaSorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. Leukemia. 2008 Apr; 22(4):808-18.Leukemia2008-01-17T00:00:002008Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway.Authorship 3738752Authorship 3738761Authorship 3738891Authorship 859573Cancer ResearchThe dual MEK/FLT3 inhibitor E6201 exerts cytotoxic activity against acute myeloid leukemia cells harboring resistance-conferring FLT3 Mutations. Cancer Research. 76:1528-1537.The dual MEK/FLT3 inhibitor E6201 exerts cytotoxic activity against acute myeloid leukemia cells harboring resistance-conferring FLT3 Mutations21575136Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF, Chan L, Hirschi KDThe FEBS journalA mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J. 2011 Jul; 278(14):2525-2539.FEBS J2011-06-02T00:00:002011A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.D011725Chemicals & Drugs54512440.591497PyridinesD001557Chemicals & Drugs1081950.898237BenzenesulfonatesD015843Chemicals & Drugs53770.948636SerpinsD051017Chemicals & Drugs3176200.78022Apoptosis Regulatory ProteinsD051941Chemicals & Drugs1228010.66804fms-Like Tyrosine Kinase 3true1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1ProfessorProfessor24739393Zhang W, Ruvolo VR, Gao C, Zhou L, Bornmann W, Tsao T, Schober WD, Smith P, Guichard S, Konopleva M, Andreeff MMolecular cancer therapeuticsEvaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 Jul; 13(7):1848-59.Mol Cancer Ther2014-04-16T00:00:002014Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.