GUILLERMINA LOZANO to Mice
This is a "connection" page, showing publications GUILLERMINA LOZANO has written about Mice.
Connection Strength
2.692
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20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer. 2009 11; 9(11):831-41.
Score: 0.077
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Crippling p53 activities via knock-in mutations in mouse models. Oncogene. 2007 Apr 02; 26(15):2177-84.
Score: 0.065
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p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator. Cancer Res Commun. 2024 Aug 01; 4(8):1991-2007.
Score: 0.054
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Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo. Sci Adv. 2024 Feb 16; 10(7):eadk1835.
Score: 0.052
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p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis. Cancer Res Commun. 2023 12 29; 3(12):2640-2652.
Score: 0.052
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Triple-negative breast tumors are dependent on mutant p53 for growth and survival. Proc Natl Acad Sci U S A. 2023 08 22; 120(34):e2308807120.
Score: 0.050
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Unique Transcriptional Profiles Underlie Osteosarcomagenesis Driven by Different p53 Mutants. Cancer Res. 2023 07 14; 83(14):2297-2311.
Score: 0.050
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Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program. Cancer Discov. 2023 05 04; 13(5):1230-1249.
Score: 0.049
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Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling. Proc Natl Acad Sci U S A. 2022 Nov 08; 119(45):e2210618119.
Score: 0.048
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p53 Activation Paradoxically Causes Liver Cancer. Cancer Res. 2022 08 16; 82(16):2824-2825.
Score: 0.047
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Is loss of p53 a driver of ductal carcinoma in situ progression? Br J Cancer. 2022 11; 127(10):1744-1754.
Score: 0.047
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Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo. Cancer Res. 2022 05 16; 82(10):1926-1936.
Score: 0.046
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Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo. Cancer Res. 2022 04 01; 82(7):1313-1320.
Score: 0.046
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Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis. Cancer Discov. 2021 08; 11(8):2094-2111.
Score: 0.043
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The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model. Cancer Res. 2021 05 01; 81(9):2442-2456.
Score: 0.043
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p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23663-23673.
Score: 0.041
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Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. Sci Adv. 2020 08; 6(32):eaba8415.
Score: 0.041
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Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6622-6629.
Score: 0.040
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Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity. Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17429-17437.
Score: 0.038
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Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination. Cancer Res. 2019 05 15; 79(10):2662-2668.
Score: 0.037
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One step at a time. Mol Biol Cell. 2018 11 01; 29(22):2614-2615.
Score: 0.036
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CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo. Cell Death Dis. 2018 Oct 27; 9(11):1099.
Score: 0.036
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Daxx Functions Are p53-Independent In Vivo. Mol Cancer Res. 2018 10; 16(10):1523-1529.
Score: 0.035
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Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2198-2203.
Score: 0.034
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Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes. Oncogene. 2018 01 18; 37(3):332-340.
Score: 0.033
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Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein. Genes Dev. 2017 09 15; 31(18):1847-1857.
Score: 0.033
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Tumorigenesis promotes Mdm4-S overexpression. Oncotarget. 2017 Apr 18; 8(16):25837-25847.
Score: 0.033
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The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. J Pathol. 2017 03; 241(4):501-510.
Score: 0.032
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Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End. Cold Spring Harb Perspect Med. 2016 08 01; 6(8).
Score: 0.031
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Distinct downstream targets manifest p53-dependent pathologies in mice. Oncogene. 2016 11 03; 35(44):5713-5721.
Score: 0.030
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p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis. Mol Cancer Res. 2016 Jan; 14(1):56-65.
Score: 0.029
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Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. Oncogene. 2016 Jan 21; 35(3):358-65.
Score: 0.028
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Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11145-50.
Score: 0.027
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Tissue-specific and age-dependent effects of global Mdm2 loss. J Pathol. 2014 Aug; 233(4):380-91.
Score: 0.027
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Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity. Oncotarget. 2014 Mar 15; 5(5):1149-56.
Score: 0.026
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The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. Hum Mutat. 2014 Jun; 35(6):728-37.
Score: 0.026
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Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors. Mol Cancer Res. 2014 Jun; 12(6):901-11.
Score: 0.026
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The mutant p53 mouse as a pre-clinical model. Oncogene. 2013 Sep 12; 32(37):4325-30.
Score: 0.024
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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans. Blood. 2012 Dec 20; 120(26):5118-27.
Score: 0.024
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Multiple stress signals activate mutant p53 in vivo. Cancer Res. 2011 Dec 01; 71(23):7168-75.
Score: 0.022
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The ups and downs of p53 regulation in hematopoietic stem cells. Cell Cycle. 2011 Oct 01; 10(19):3257-62.
Score: 0.022
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Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010 Nov 05; 7(5):606-17.
Score: 0.021
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Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. J Pathol. 2011 Jan; 223(2):127-36.
Score: 0.021
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You can win by losing: p53 mutations in rhabdomyosarcomas. J Pathol. 2010 Oct; 222(2):124-8.
Score: 0.021
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Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4. Cancer Res. 2010 Sep 15; 70(18):7148-54.
Score: 0.021
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Mouse models of p53 functions. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a001115.
Score: 0.020
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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis. 2009 Oct; 30(10):1789-95.
Score: 0.019
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Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation. 2009 Jun; 77(5):442-9.
Score: 0.019
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EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res. 2008 Nov 01; 68(21):8968-75.
Score: 0.018
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The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death Differ. 2008 Nov; 15(11):1772-81.
Score: 0.018
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Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res. 2008 Jun; 6(6):947-54.
Score: 0.018
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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev. 2008 May 15; 22(10):1337-44.
Score: 0.018
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The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol. 2007 Dec; 213(4):360-8.
Score: 0.017
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Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene. 2008 Mar 20; 27(13):1813-20.
Score: 0.017
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Mammary tumor modifiers in BALB/cJ mice heterozygous for p53. Mamm Genome. 2007 May; 18(5):300-9.
Score: 0.016
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Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation. 2007 Jun 12; 115(23):2925-30.
Score: 0.016
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Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Mol Cell Biol. 2007 Aug; 27(15):5479-85.
Score: 0.016
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A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene. 2007 Oct 18; 26(48):6896-904.
Score: 0.016
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New mouse models of cancer: single-cell knockouts. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4245-6.
Score: 0.016
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The oncogenic roles of p53 mutants in mouse models. Curr Opin Genet Dev. 2007 Feb; 17(1):66-70.
Score: 0.016
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p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19842-7.
Score: 0.016
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Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. Cancer Res. 2006 Oct 01; 66(19):9502-8.
Score: 0.016
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Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 2006 Jun; 13(6):927-34.
Score: 0.015
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Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3226-31.
Score: 0.015
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Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol. 2006 Jan; 26(1):192-8.
Score: 0.015
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p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun. 2005 Jun 10; 331(3):834-42.
Score: 0.014
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What have animal models taught us about the p53 pathway? J Pathol. 2005 Jan; 205(2):206-20.
Score: 0.014
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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004 Dec 17; 119(6):861-72.
Score: 0.014
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Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene. 2004 Oct 07; 23(46):7644-50.
Score: 0.014
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Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis. Cancer Immunol Res. 2024 Sep 03; 12(9):1170-1183.
Score: 0.014
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Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer. Elife. 2024 Aug 30; 13.
Score: 0.014
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A novel genetic modifier of p53, mop1, results in embryonic lethality. Mamm Genome. 2004 Jun; 15(6):415-23.
Score: 0.013
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Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet. 2004 Jan; 36(1):63-8.
Score: 0.013
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Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res. 2003 Dec 15; 63(24):8664-9.
Score: 0.013
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The histone chaperone function of Daxx is dispensable for embryonic development. Cell Death Dis. 2023 08 26; 14(8):565.
Score: 0.013
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Disrupting TP53 in mouse models of human cancers. Hum Mutat. 2003 Mar; 21(3):321-6.
Score: 0.012
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EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma. Neuro Oncol. 2022 10 03; 24(10):1712-1725.
Score: 0.012
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Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss. Cell Death Dis. 2022 09 08; 13(9):777.
Score: 0.012
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Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas. Dis Model Mech. 2022 08 01; 15(8).
Score: 0.012
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Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland. Oncogene. 2002 May 16; 21(22):3525-31.
Score: 0.012
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Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb; 32(2):145-7.
Score: 0.011
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Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun. 2021 09 10; 12(1):5389.
Score: 0.011
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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet. 2001 Sep; 29(1):92-5.
Score: 0.011
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An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2. Oncogene. 2001 Jul 05; 20(30):4041-9.
Score: 0.011
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Organization, expression, and localization of the murine mdmx gene and pseudogene. Gene. 2001 May 30; 270(1-2):277-83.
Score: 0.011
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Wnt/?-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells. Cell Death Dis. 2021 05 21; 12(6):521.
Score: 0.011
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MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism. Cancer Cell. 2021 04 12; 39(4):529-547.e7.
Score: 0.011
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High metastatic potential in mice inheriting a targeted p53 missense mutation. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4174-9.
Score: 0.010
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The loss of mdm2 induces p53-mediated apoptosis. Oncogene. 2000 Mar 23; 19(13):1691-7.
Score: 0.010
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Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J Pathol. 1999 Jul; 188(3):322-8.
Score: 0.009
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Overproduction of MDM2 in vivo disrupts S phase independent of E2F1. Cell Growth Differ. 1999 Mar; 10(3):147-54.
Score: 0.009
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Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):960-969.
Score: 0.009
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Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. 2018 07; 155(1):210-223.e3.
Score: 0.009
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A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. PLoS One. 2018; 13(3):e0193485.
Score: 0.009
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Mouse models dissect the role of p53 in cancer and development. Semin Cancer Biol. 1998; 8(5):337-44.
Score: 0.009
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The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo. Oncogene. 1997 Sep 25; 15(13):1527-34.
Score: 0.008
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Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality. Nat Genet. 1997 Aug; 16(4):336-7.
Score: 0.008
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Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem. 1996 Nov 15; 271(46):29380-5.
Score: 0.008
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The organization and expression of the mdm2 gene. Genomics. 1996 May 01; 33(3):352-7.
Score: 0.008
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Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo. Clin Cancer Res. 2016 08 01; 22(15):3876-83.
Score: 0.008
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MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Mol Cell. 2016 Jan 07; 61(1):68-83.
Score: 0.007
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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 1995 Nov 09; 378(6553):203-6.
Score: 0.007
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Cyclin E restores p53 activity in contact-inhibited cells. Mol Cell Biol. 1995 Jul; 15(7):3926-33.
Score: 0.007
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TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. J Hepatol. 2015 Feb; 62(2):371-9.
Score: 0.007
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Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer. J Pathol. 2014 Sep; 234(1):108-19.
Score: 0.007
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Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. Cell Rep. 2014 Jun 12; 7(5):1691-1703.
Score: 0.007
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USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol. 2014 Jun; 15(6):562-70.
Score: 0.007
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ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17969-74.
Score: 0.006
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The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev. 2013 Sep 01; 27(17):1857-67.
Score: 0.006
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DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-?-driven epithelial-mesenchymal transition. Cancer Discov. 2013 Oct; 3(10):1172-89.
Score: 0.006
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The tumor suppressor p53 regulates its own transcription. Mol Cell Biol. 1993 Jun; 13(6):3415-23.
Score: 0.006
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Mutant p53 prolongs NF-?B activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell. 2013 May 13; 23(5):634-46.
Score: 0.006
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Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner. Cell Cycle. 2013 Jun 01; 12(11):1722-31.
Score: 0.006
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Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis. Cell Death Differ. 2013 May; 20(5):732-43.
Score: 0.006
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p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell. 2012 Jun 12; 21(6):793-806.
Score: 0.006
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Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation. Cell Death Differ. 2012 Aug; 19(8):1381-9.
Score: 0.006
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Analysis of p53 mutants for transcriptional activity. Mol Cell Biol. 1991 Dec; 11(12):6067-74.
Score: 0.006
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Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop. Cell Death Differ. 2012 Jan; 19(1):180-3.
Score: 0.006
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Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-? (TGF-?). J Biol Chem. 2011 Dec 23; 286(51):44023-44034.
Score: 0.006
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An intron binding protein is required for transformation ability of p53. Nucleic Acids Res. 1991 Sep 11; 19(17):4747-52.
Score: 0.006
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Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011 Aug 16; 20(2):260-75.
Score: 0.005
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A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell. 2011 Jul 12; 20(1):79-91.
Score: 0.005
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Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11995-2000.
Score: 0.005
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Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug; 224(4):540-52.
Score: 0.005
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Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest. 2011 Mar; 121(3):893-904.
Score: 0.005
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Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011 Mar; 121(3):851-65.
Score: 0.005
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Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences. Mol Carcinog. 1991; 4(1):3-9.
Score: 0.005
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p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell Melanoma Res. 2010 Dec; 23(6):781-94.
Score: 0.005
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p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. Cancer Res. 2010 Dec 01; 70(23):9650-8.
Score: 0.005
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A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell. 2010 Sep 14; 18(3):220-30.
Score: 0.005
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Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010 Nov 18; 29(46):6125-37.
Score: 0.005
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The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28; 32(5):670-80.
Score: 0.005
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A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis. Oncogene. 2010 Jun 03; 29(22):3287-96.
Score: 0.005
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Transcriptional mechanisms controlling types I and III collagen genes. Ann N Y Acad Sci. 1990; 580:88-96.
Score: 0.005
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p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis. Oncogene. 2010 Mar 04; 29(9):1260-9.
Score: 0.005
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E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol. 2010 Jan; 30(2):524-36.
Score: 0.005
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Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS One. 2009; 4(4):e5401.
Score: 0.005
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p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner. PLoS One. 2008; 3(11):e3707.
Score: 0.005
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An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest. 2007 Jul; 117(7):1893-901.
Score: 0.004
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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 2007 May; 8(5):497-503.
Score: 0.004
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Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007 May; 27(9):3405-16.
Score: 0.004
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Distinct roles of Mdm2 and Mdm4 in red cell production. Blood. 2007 Mar 15; 109(6):2630-3.
Score: 0.004
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Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice. Genes Chromosomes Cancer. 2006 Jul; 45(7):668-75.
Score: 0.004
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MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis. Cancer Lett. 2005 Oct 18; 228(1-2):21-7.
Score: 0.004
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Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol. 2005 Jun; 19(6):1646-53.
Score: 0.004
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Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Res. 2004 Dec 15; 64(24):9080-5.
Score: 0.003
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Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol. 2004 Oct; 24(20):8884-94.
Score: 0.003
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RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties. Carcinogenesis. 2004 Feb; 25(2):157-67.
Score: 0.003
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14-3-3 sigma positively regulates p53 and suppresses tumor growth. Mol Cell Biol. 2003 Oct; 23(20):7096-107.
Score: 0.003
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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell. 2003 Mar 21; 112(6):779-91.
Score: 0.003
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The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells. Neurosci Lett. 2002 Dec 06; 334(1):1-4.
Score: 0.003
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p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells. Cell Death Differ. 2002 May; 9(5):549-60.
Score: 0.003
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Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem. 2002 May 31; 277(22):19251-4.
Score: 0.003
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p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev. 2000 Sep 15; 14(18):2358-65.
Score: 0.003
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Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice. J Virol. 1999 Dec; 73(12):9976-83.
Score: 0.002
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The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53. Biochem Biophys Res Commun. 1999 Aug 02; 261(2):464-71.
Score: 0.002
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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J. 1999 Apr 01; 18(7):1805-14.
Score: 0.002
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The cenpB gene is not essential in mice. Chromosoma. 1998 Dec; 107(8):570-6.
Score: 0.002
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Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes. J Natl Cancer Inst. 1998 Aug 05; 90(15):1130-7.
Score: 0.002
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Bcl-2 inhibits p53 nuclear import following DNA damage. Oncogene. 1997 Dec 04; 15(23):2767-72.
Score: 0.002
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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 1997 Mar 15; 11(6):714-25.
Score: 0.002
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Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment. Radiat Res. 1997 Jan; 147(1):1-12.
Score: 0.002
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mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts. Oncogene. 1996 Oct 17; 13(8):1731-6.
Score: 0.002
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Developmental control of transcription of the CAT reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice. Mol Reprod Dev. 1995 Sep; 42(1):1-6.
Score: 0.002
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Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Mol Carcinog. 1995 Jun; 13(2):104-11.
Score: 0.002
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PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol. 1994 Oct; 14(10):6858-67.
Score: 0.002
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SV40 T antigen abrogates p53-mediated transcriptional activity. Oncogene. 1993 Oct; 8(10):2805-12.
Score: 0.002
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Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem. 1992 Sep 25; 267(27):19622-30.
Score: 0.001
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Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9648-52.
Score: 0.001
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The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice. Prog Clin Biol Res. 1988; 284:163-86.
Score: 0.001
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Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice. J Virol. 1987 Jun; 61(6):2029-32.
Score: 0.001
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Serotonin 5-HT1C receptors are expressed at high density on choroid plexus tumors from transgenic mice. Brain Res. 1986 Oct 22; 385(2):389-94.
Score: 0.001