HELEN PIWNICA-WORMS to Checkpoint Kinase 1
This is a "connection" page, showing publications HELEN PIWNICA-WORMS has written about Checkpoint Kinase 1.
Connection Strength
1.229
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CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res. 2018 02 01; 78(3):781-797.
Score: 0.142
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CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res. 2017 07 15; 77(14):3870-3884.
Score: 0.136
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CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Mol Cell Biol. 2013 Jan; 33(2):213-26.
Score: 0.099
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Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr; 122(4):1541-52.
Score: 0.095
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Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene. 2013 Jan 31; 32(5):577-88.
Score: 0.095
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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med. 2011 Feb; 17(2):88-96.
Score: 0.087
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DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res. 2009 Mar 15; 69(6):2630-7.
Score: 0.077
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GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 2008 Jan; 13(1):36-47.
Score: 0.071
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Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol. 2006 Oct; 26(20):7529-38.
Score: 0.065
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Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol. 2003 Nov; 23(21):7488-97.
Score: 0.053
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Cdc25A regulation: to destroy or not to destroy--is that the only question? Cell Cycle. 2003 Sep-Oct; 2(5):455-7.
Score: 0.053
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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14795-800.
Score: 0.050
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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001 Jul; 21(13):4129-39.
Score: 0.045
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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem. 2000 Feb 25; 275(8):5600-5.
Score: 0.041
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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell. 2019 06 20; 74(6):1123-1137.e6.
Score: 0.039
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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 1997 Sep 05; 277(5331):1501-5.
Score: 0.035
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Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 2005 Feb; 7(2):193-204.
Score: 0.015
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The human decatenation checkpoint. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12044-9.
Score: 0.012
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Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature. 1998 Oct 01; 395(6701):507-10.
Score: 0.009
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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 05; 277(5331):1497-501.
Score: 0.009