HELEN PIWNICA-WORMS to Protein Kinases
This is a "connection" page, showing publications HELEN PIWNICA-WORMS has written about Protein Kinases.
Connection Strength
2.931
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CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Mol Cell Biol. 2013 Jan; 33(2):213-26.
Score: 0.320
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Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr; 122(4):1541-52.
Score: 0.307
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Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene. 2013 Jan 31; 32(5):577-88.
Score: 0.306
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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med. 2011 Feb; 17(2):88-96.
Score: 0.279
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DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res. 2009 Mar 15; 69(6):2630-7.
Score: 0.248
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Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol. 2006 Oct; 26(20):7529-38.
Score: 0.207
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Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol. 2003 Nov; 23(21):7488-97.
Score: 0.171
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Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase. Nature. 1993 Jun 24; 363(6431):736-8.
Score: 0.084
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A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. EMBO J. 1993 May; 12(5):1947-54.
Score: 0.083
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Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992 Sep 25; 257(5078):1955-7.
Score: 0.079
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p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2917-21.
Score: 0.077
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Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. EMBO J. 1991 May; 10(5):1255-63.
Score: 0.072
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p107wee1 is a serine/threonine and tyrosine kinase that promotes the tyrosine phosphorylation of the cyclin/p34cdc2 complex. Cold Spring Harb Symp Quant Biol. 1991; 56:567-76.
Score: 0.070
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GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 2008 Jan; 13(1):36-47.
Score: 0.057
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Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe. 2007 Jun 14; 1(4):275-86.
Score: 0.055
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Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 2005 Feb; 7(2):193-204.
Score: 0.047
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Cdc25A regulation: to destroy or not to destroy--is that the only question? Cell Cycle. 2003 Sep-Oct; 2(5):455-7.
Score: 0.042
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C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell. 2001 Nov; 8(5):983-93.
Score: 0.037
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Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 2000 Nov 01; 60(21):5934-6.
Score: 0.035
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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem. 2000 Feb 25; 275(8):5600-5.
Score: 0.033
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DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding. Mol Cell Biol. 1999 Nov; 19(11):7410-9.
Score: 0.032
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A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3745-50.
Score: 0.031
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Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature. 1998 Oct 01; 395(6701):507-10.
Score: 0.030
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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 05; 277(5331):1497-501.
Score: 0.028
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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 1997 Sep 05; 277(5331):1501-5.
Score: 0.028
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Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol. 1994 Nov 01; 4(11):973-82.
Score: 0.023
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Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett. 1993 Dec 28; 336(3):417-24.
Score: 0.022
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Reversible tyrosine phosphorylation and cell cycle control. Semin Cell Biol. 1993 Dec; 4(6):433-42.
Score: 0.022
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Mechanisms of p34cdc2 regulation. Mol Cell Biol. 1993 Mar; 13(3):1675-85.
Score: 0.020
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Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex. J Biol Chem. 1992 Sep 05; 267(25):18040-6.
Score: 0.020
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Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J Virol. 1990 Jan; 64(1):61-8.
Score: 0.016
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The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus. Mol Cell Biol. 1988 Apr; 8(4):1736-47.
Score: 0.015
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Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12288-93.
Score: 0.011
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The human decatenation checkpoint. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12044-9.
Score: 0.009
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New perspectives on Raf-1: the involvement of p21ras in the activation of Raf-1 and a potential role for Raf-1 in events occurring later in the cell cycle. Cold Spring Harb Symp Quant Biol. 1991; 56:251-63.
Score: 0.009
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Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. J Biol Chem. 1992 Mar 15; 267(8):5408-15.
Score: 0.005