HELEN PIWNICA-WORMS to Humans
This is a "connection" page, showing publications HELEN PIWNICA-WORMS has written about Humans.
Connection Strength
0.370
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Single-cell evaluation reveals shifts in the tumor-immune niches that shape and maintain aggressive lesions in the breast. Nat Commun. 2021 08 18; 12(1):5024.
Score: 0.015
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Pharmacologic profiling of patient-derived xenograft models of primary treatment-na?ve triple-negative breast cancer. Sci Rep. 2020 10 21; 10(1):17899.
Score: 0.014
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Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state. Sci Transl Med. 2019 04 17; 11(488).
Score: 0.013
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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer. Nat Commun. 2018 11 29; 9(1):5079.
Score: 0.013
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Intratumoral Heterogeneity in Ductal Carcinoma In Situ: Chaos and Consequence. J Mammary Gland Biol Neoplasia. 2018 12; 23(4):191-205.
Score: 0.012
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p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer. Breast Cancer Res. 2016 Jan 27; 18(1):13.
Score: 0.010
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Contribution of p53 to metastasis. Cancer Discov. 2014 Apr; 4(4):405-14.
Score: 0.009
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Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity. J Cell Sci. 2014 Jan 15; 127(Pt 2):315-27.
Score: 0.009
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CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Mol Cell Biol. 2013 Jan; 33(2):213-26.
Score: 0.008
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Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J Clin Invest. 2012 Apr; 122(4):1541-52.
Score: 0.008
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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends Mol Med. 2011 Feb; 17(2):88-96.
Score: 0.007
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A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies. Cancer Chemother Pharmacol. 2011 Jun; 67(6):1225-37.
Score: 0.007
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Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction. Oncogene. 2010 Jun 10; 29(23):3324-34.
Score: 0.007
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DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res. 2009 Mar 15; 69(6):2630-7.
Score: 0.006
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Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18378-83.
Score: 0.006
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Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol. 2008 Oct; 28(19):5874-85.
Score: 0.006
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GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 2008 Jan; 13(1):36-47.
Score: 0.006
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The Par-1/MARK family of protein kinases: from polarity to metabolism. Cell Cycle. 2007 Aug 15; 6(16):1966-9.
Score: 0.006
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Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Mol Cell Biol. 2006 Oct; 26(20):7529-38.
Score: 0.005
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BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024 Aug 02; 14(8):1476-1495.
Score: 0.005
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Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem. 2004 Jul 30; 279(31):32046-54.
Score: 0.005
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Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. Curr Biol. 2004 Apr 20; 14(8):736-41.
Score: 0.005
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Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol. 2003 Nov; 23(21):7488-97.
Score: 0.004
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Cdc25A regulation: to destroy or not to destroy--is that the only question? Cell Cycle. 2003 Sep-Oct; 2(5):455-7.
Score: 0.004
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Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. Mol Cancer Res. 2003 Jun; 1(8):598-609.
Score: 0.004
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Targeting chemotherapy resistance in mesenchymal triple-negative breast cancer: a phase II trial of neoadjuvant angiogenic and mTOR inhibition with chemotherapy. Invest New Drugs. 2023 Jun; 41(3):391-401.
Score: 0.004
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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14795-800.
Score: 0.004
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14-3-3 binding regulates catalytic activity of human Wee1 kinase. Cell Growth Differ. 2001 Dec; 12(12):581-9.
Score: 0.004
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Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer. Br J Cancer. 2022 03; 126(4):615-627.
Score: 0.004
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Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun. 2021 09 10; 12(1):5389.
Score: 0.004
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The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators. J Biol Chem. 2001 Oct 05; 276(40):37166-77.
Score: 0.004
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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001 Jul; 21(13):4129-39.
Score: 0.004
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Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase. Mol Cell Biol. 2001 Jun; 21(12):3853-61.
Score: 0.004
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Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Mol Cell Biol. 2001 May; 21(9):3206-19.
Score: 0.004
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Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene. 2001 Apr 05; 20(15):1839-51.
Score: 0.004
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Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells. J Immunother Cancer. 2021 03; 9(3).
Score: 0.004
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A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations. Breast Cancer Res. 2020 11 04; 22(1):121.
Score: 0.004
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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem. 2000 Feb 25; 275(8):5600-5.
Score: 0.003
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The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing. Nat Commun. 2020 01 24; 11(1):486.
Score: 0.003
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Cell cycle. Fools rush in. Nature. 1999 Oct 07; 401(6753):535, 537.
Score: 0.003
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Neoadjuvant Talazoparib for Patients With Operable Breast Cancer With a Germline BRCA Pathogenic Variant. J Clin Oncol. 2020 02 10; 38(5):388-394.
Score: 0.003
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Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 2019 08 22; 178(5):1115-1131.e15.
Score: 0.003
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6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers. Clin Cancer Res. 2019 09 15; 25(18):5702-5716.
Score: 0.003
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Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Mol Cell Biol. 1999 Jul; 19(7):5113-23.
Score: 0.003
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Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer. Cancer Res. 2019 08 15; 79(16):4211-4226.
Score: 0.003
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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell. 2019 06 20; 74(6):1123-1137.e6.
Score: 0.003
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BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9600-E9609.
Score: 0.003
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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Mol Cell. 2018 08 16; 71(4):606-620.e7.
Score: 0.003
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Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell Rep. 2018 04 03; 23(1):213-226.e3.
Score: 0.003
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C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ. 1998 Mar; 9(3):197-208.
Score: 0.003
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CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res. 2018 02 01; 78(3):781-797.
Score: 0.003
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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 1997 Sep 05; 277(5331):1501-5.
Score: 0.003
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CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. Cancer Res. 2017 07 15; 77(14):3870-3884.
Score: 0.003
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The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol Cell Biol. 1997 Feb; 17(2):571-83.
Score: 0.003
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Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer Metastasis Rev. 2016 12; 35(4):547-573.
Score: 0.003
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Reversible phosphorylation and mitotic control. J Lab Clin Med. 1996 Oct; 128(4):350-4.
Score: 0.003
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Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene. 2016 11 17; 35(46):5977-5988.
Score: 0.003
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Identification of a 95-kDa WEE1-like tyrosine kinase in HeLa cells. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9638-42.
Score: 0.003
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Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. DNA Repair (Amst). 2015 Nov; 35:106-15.
Score: 0.003
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Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem. 2015 Jun 12; 290(24):15133-45.
Score: 0.002
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14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. J Biol Chem. 2015 May 08; 290(19):12300-12.
Score: 0.002
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Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. J Biol Chem. 2015 Apr 03; 290(14):9075-86.
Score: 0.002
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Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216. J Biol Chem. 1994 Dec 02; 269(48):30461-9.
Score: 0.002
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Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol. 1994 Dec; 14(12):8420-31.
Score: 0.002
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Cell cycle regulation of the p34cdc2 inhibitory kinases. Mol Biol Cell. 1994 Sep; 5(9):989-1001.
Score: 0.002
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A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. EMBO J. 1993 May; 12(5):1947-54.
Score: 0.002
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Mechanisms of p34cdc2 regulation. Mol Cell Biol. 1993 Mar; 13(3):1675-85.
Score: 0.002
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A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. Breast Cancer Res Treat. 2013 Jan; 137(2):483-92.
Score: 0.002
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Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992 Sep 25; 257(5078):1955-7.
Score: 0.002
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Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10; 486(7403):353-60.
Score: 0.002
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Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem. 2012 Jun 22; 287(26):21980-91.
Score: 0.002
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Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. EMBO J. 1991 May; 10(5):1255-63.
Score: 0.002
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p107wee1 is a serine/threonine and tyrosine kinase that promotes the tyrosine phosphorylation of the cyclin/p34cdc2 complex. Cold Spring Harb Symp Quant Biol. 1991; 56:567-76.
Score: 0.002
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Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. PLoS Pathog. 2010 Mar 19; 6(3):e1000814.
Score: 0.002
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The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. J Immunol. 2009 Jul 15; 183(2):1215-21.
Score: 0.002
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Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. J Cell Biol. 2008 Apr 07; 181(1):89-103.
Score: 0.002
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Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe. 2007 Jun 14; 1(4):275-86.
Score: 0.001
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Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 2007; 21(21):3443-51.
Score: 0.001
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New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Mol Cell Biol. 2006 Oct; 26(19):7086-102.
Score: 0.001
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Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8534-9.
Score: 0.001
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Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase. Anal Chem. 2006 Apr 01; 78(7):2171-81.
Score: 0.001
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Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells. J Biol Chem. 1985 Sep 05; 260(19):10503-11.
Score: 0.001
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Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 2005 Feb; 7(2):193-204.
Score: 0.001
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Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12288-93.
Score: 0.001
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Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nat Cell Biol. 2003 Jun; 5(6):545-51.
Score: 0.001
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Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6961-6.
Score: 0.001
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Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1990-5.
Score: 0.001
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The human decatenation checkpoint. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12044-9.
Score: 0.001
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New perspectives on Raf-1: the involvement of p21ras in the activation of Raf-1 and a potential role for Raf-1 in events occurring later in the cell cycle. Cold Spring Harb Symp Quant Biol. 1991; 56:251-63.
Score: 0.001
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Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 2000 Nov 01; 60(21):5934-6.
Score: 0.001
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A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3745-50.
Score: 0.001
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14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol Cell Biol. 1998 Sep; 18(9):5229-38.
Score: 0.001
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Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell. 1998 May 15; 93(4):617-25.
Score: 0.001
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Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein. J Biol Chem. 1997 Oct 24; 272(43):27281-7.
Score: 0.001
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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 05; 277(5331):1497-501.
Score: 0.001
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Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol. 1994 Nov 01; 4(11):973-82.
Score: 0.001
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Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett. 1993 Dec 28; 336(3):417-24.
Score: 0.001
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Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex. J Biol Chem. 1992 Sep 05; 267(25):18040-6.
Score: 0.001
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Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. J Biol Chem. 1992 Mar 15; 267(8):5408-15.
Score: 0.000
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cdc2 gene expression at the G1 to S transition in human T lymphocytes. Science. 1990 Nov 09; 250(4982):805-8.
Score: 0.000
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The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell. 1989 Sep 22; 58(6):1085-95.
Score: 0.000
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Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5131-5.
Score: 0.000