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VALERIE LEBLEU

TitleAssistant Professor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou X, LeBleu VS, Fletcher-Sananikone E, Kim J, Dai J, Li B, Wu CC, Sugimoto H, Miyake T, Becker LM, Volpert OV, Lawson E, Espinosa Da Silva C, Patel SI, Kizu A, Ehsanipour EA, Sha D, Karam JA, McAndrews KM, Kalluri R. Vascular heterogeneity of tight junction Claudins guides organotropic metastasis. Nat Cancer. 2024 Sep; 5(9):1371-1389. PMID: 39289595.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Luo X, McAndrews KM, Arian KA, Morse SJ, Boeker V, Kumbhar SV, Hu Y, Mahadevan KK, Church KA, Chitta S, Ryujin NT, Hensel J, Dai J, Dowlatshahi DP, Sugimoto H, Kirtley ML, LeBleu VS, Shalapour S, Simmons JH, Kalluri R. Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity. J Control Release. 2024 Oct; 374:550-562. PMID: 39146981.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. LeBleu VS, Kanasaki K, Lovisa S, Alge JL, Kim J, Chen Y, Teng Y, Gerami-Naini B, Sugimoto H, Kato N, Revuelta I, Grau N, Sleeman JP, Taduri G, Kizu A, Rafii S, Hochedlinger K, Quaggin SE, Kalluri R. Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome. Life Sci Alliance. 2024 Jun; 7(6). PMID: 38561223; PMCID: PMC10985218.
      Citations:    Fields:    Translation:AnimalsCells
    4. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2024 Mar; 30(3):908. PMID: 38017076.
      Citations:    Fields:    
    5. Kugeratski FG, LeBleu VS, Dowlatshahi DP, Sugimoto H, Arian KA, Fan Y, Huang L, Wells D, Lilla S, Hodge K, Zanivan S, McAndrews KM, Kalluri R. Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity. bioRxiv. 2023 Nov 04. PMID: 37961535; PMCID: PMC10635085.
      Citations:    
    6. Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Paradiso F, Sugimoto H, Arian KA, Ying H, Barekatain Y, Sthanam LK, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T?cells. Cancer Cell. 2023 09 11; 41(9):1606-1620.e8. PMID: 37625401; PMCID: PMC10785700.
      Citations: 6     Fields:    Translation:HumansCells
    7. Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Sthanam LK, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T?cells. Dev Cell. 2023 09 11; 58(17):1562-1577.e8. PMID: 37625403; PMCID: PMC10810082.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. LeBleu VS, Dai J, Tsutakawa S, MacDonald BA, Alge JL, Sund M, Xie L, Sugimoto H, Tainer J, Zon LI, Kalluri R. Identification of unique a4 chain structure and conserved antiangiogenic activity of a3NC1 type IV collagen in zebrafish. Dev Dyn. 2023 07; 252(7):1046-1060. PMID: 37002899; PMCID: PMC10524752.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Sugimoto H, Arian KA, Ying H, Barekatain Y, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. Oncogenic Kras G12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8 + T cells dependent manner. bioRxiv. 2023 Feb 18. PMID: 36824971; PMCID: PMC9948969.
      Citations:    
    10. Haltom AR, Hassen WE, Hensel J, Kim J, Sugimoto H, Li B, McAndrews KM, Conner MR, Kirtley ML, Luo X, Xie B, Volpert OV, Olalekan S, Maltsev N, Basu A, LeBleu VS, Kalluri R. Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma. Extracell Vesicle. 2022 Dec; 1. PMID: 37503329; PMCID: PMC10373511.
      Citations: 3     
    11. Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R. Author Correction: Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2022 Oct; 610(7932):E15-E17. PMID: 36198804.
      Citations:    Fields:    
    12. McAndrews KM, Chen Y, Darpolor JK, Zheng X, Yang S, Carstens JL, Li B, Wang H, Miyake T, Correa de Sampaio P, Kirtley ML, Natale M, Wu CC, Sugimoto H, LeBleu VS, Kalluri R. Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discov. 2022 06 02; 12(6):1580-1597. PMID: 35348629; PMCID: PMC9399904.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    13. LeBleu VS. Plasticity Enables Cooperation among Heterogeneous Cancer Cell Populations to Support Metastatic Fitness. Cancer Res. 2022 05 16; 82(10):1870-1871. PMID: 35570704.
      Citations:    Fields:    Translation:HumansCells
    14. LeBleu VS, Thiery JP. The Continuing Search for Causality between Epithelial-to-Mesenchymal Transition and the Metastatic Fitness of Carcinoma Cells. Cancer Res. 2022 04 15; 82(8):1467-1469. PMID: 35425957.
      Citations:    Fields:    Translation:Humans
    15. McAndrews KM, Miyake T, Ehsanipour EA, Kelly PJ, Becker LM, McGrail DJ, Sugimoto H, LeBleu VS, Ge Y, Kalluri R. Dermal aSMA+ myofibroblasts orchestrate skin wound repair via ?1 integrin and independent of type I collagen production. EMBO J. 2022 04 04; 41(7):e109470. PMID: 35212000; PMCID: PMC8982612.
      Citations: 3     Fields:    Translation:AnimalsCells
    16. El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2. Nat Commun. 2022 01 20; 13(1):405. PMID: 35058437; PMCID: PMC8776790.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. McAndrews KM, Xiao F, Chronopoulos A, LeBleu VS, Kugeratski FG, Kalluri R. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer. Life Sci Alliance. 2021 09; 4(9). PMID: 34282051; PMCID: PMC8321670.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. McAndrews KM, Kwak C, Sugimoto H, Zheng X, Li B, Kirtley ML, LeBleu VS, Kalluri R, V?zquez-Arregu?n K. aSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression. Oncogene. 2021 07; 40(26):4440-4452. PMID: 34108617; PMCID: PMC9150816.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Zhou X, Kurywchak P, Wolf-Dennen K, Che SPY, Sulakhe D, D'Souza M, Xie B, Maltsev N, Gilliam TC, Wu CC, McAndrews KM, LeBleu VS, McConkey DJ, Volpert OV, Pretzsch SM, Czerniak BA, Dinney CP, Kalluri R. Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer. Mol Ther Methods Clin Dev. 2021 Sep 10; 22:360-376. PMID: 34514028; PMCID: PMC8408559.
      Citations: 2     
    20. Tang M, Chen Y, Li B, Sugimoto H, Yang S, Yang C, LeBleu VS, McAndrews KM, Kalluri R. Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis. FASEB J. 2021 05; 35(5):e21557. PMID: 33855751; PMCID: PMC10851328.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. McAndrews KM, Che SPY, LeBleu VS, Kalluri R. Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity. J Biol Chem. 2021 Jan-Jun; 296:100523. PMID: 33711340; PMCID: PMC8042450.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. Chen Y, Kim J, Yang S, Wang H, Wu CJ, Sugimoto H, LeBleu VS, Kalluri R. Type I collagen deletion in aSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. Cancer Cell. 2021 04 12; 39(4):548-565.e6. PMID: 33667385; PMCID: PMC8423173.
      Citations: 61     Fields:    Translation:AnimalsCells
    23. Hensel J, McAndrews KM, McGrail DJ, Dowlatshahi DP, LeBleu VS, Kalluri R. Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses. Sci Rep. 2020 10 27; 10(1):18377. PMID: 33110184; PMCID: PMC7591473.
      Citations: 32     Fields:    Translation:HumansPHPublic Health
    24. McAndrews KM, Dowlatshahi DP, Dai J, Becker LM, Hensel J, Snowden LM, Leveille JM, Brunner MR, Holden KW, Hopkins NS, Harris AM, Kumpati J, Whitt MA, Lee JJ, Ostrosky-Zeichner LL, Papanna R, LeBleu VS, Allison JP, Kalluri R. Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity. JCI Insight. 2020 09 17; 5(18). PMID: 32796155; PMCID: PMC7526535.
      Citations: 64     Fields:    Translation:HumansCellsPHPublic Health
    25. Lovisa S, Fletcher-Sananikone E, Sugimoto H, Hensel J, Lahiri S, Hertig A, Taduri G, Lawson E, Dewar R, Revuelta I, Kato N, Wu CJ, Bassett RL, Putluri N, LeBleu VS, Kalluri R, Zeisberg M, Zeisberg EM. Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis. Sci Signal. 2020 06 09; 13(635). PMID: 32518142; PMCID: PMC7790440.
      Citations: 17     Fields:    Translation:Animals
    26. Becker LM, O'Connell JT, Vo AP, Cain MP, Bizarro L, Sugimoto H, McGow AK, Asara JM, Lovisa S, McAndrews KM, Zielinski R, Lorenzi PL, Raza S, LeBleu VS, Kalluri R, Tampe D, Zeisberg M. Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer. Cell Rep. 2020 06 02; 31(9):107701. PMID: 32492417; PMCID: PMC7339325.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    27. LeBleu VS, Kalluri R. Exosomes as a Multicomponent Biomarker Platform in Cancer. Trends Cancer. 2020 09; 6(9):767-774. PMID: 32307267.
      Citations: 68     Fields:    Translation:HumansCells
    28. LeBleu VS, Neilson EG. Origin and functional heterogeneity of fibroblasts. FASEB J. 2020 03; 34(3):3519-3536. PMID: 32037627.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    29. Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020 02 07; 367(6478). PMID: 32029601; PMCID: PMC7717626.
      Citations: 1149     Fields:    Translation:HumansAnimalsCells
    30. Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, Cogdill AP, Liu W, LeBleu VS, Kugeratski FG, Patel S, Davies MA, Hwu P, Lee JE, Gershenwald JE, Lucci A, Arora R, Woodman S, Keung EZ, Gaudreau PO, Reuben A, Spencer CN, Burton EM, Haydu LE, Lazar AJ, Zapassodi R, Hudgens CW, Ledesma DA, Ong S, Bailey M, Warren S, Rao D, Krijgsman O, Rozeman EA, Peeper D, Blank CU, Schumacher TN, Butterfield LH, Zelazowska MA, McBride KM, Kalluri R, Allison J, Petitprez F, Fridman WH, Hacohen N, Rezvani K, Sharma P, Tetzlaff MT, Wang L, Wargo JA, Saut?s-Fridman C. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020 01; 577(7791):549-555. PMID: 31942075; PMCID: PMC8762581.
      Citations: 512     Fields:    Translation:HumansCells
    31. Green NH, Galvan DL, Badal SS, Chang BH, LeBleu VS, Long J, Jonasch E, Danesh FR. MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma. Oncogene. 2019 08; 38(34):6211-6225. PMID: 31289360; PMCID: PMC8040069.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    32. McAndrews KM, LeBleu VS, Kalluri R. SIRT1 Regulates Lysosome Function and Exosome Secretion. Dev Cell. 2019 05 06; 49(3):302-303. PMID: 31063745.
      Citations: 8     Fields:    Translation:HumansCells
    33. LeBleu VS, Kalluri R. Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy. Immunity. 2019 03 19; 50(3):547-549. PMID: 30893584.
      Citations: 13     Fields:    Translation:HumansCells
    34. Chen Y, Keskin D, Sugimoto H, Kanasaki K, Phillips PE, Bizarro L, Sharpe A, LeBleu VS, Kalluri R. Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis. PLoS Biol. 2018 12; 16(12):e2005907. PMID: 30592710; PMCID: PMC6310240.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    35. Parchem JG, Kanasaki K, Kanasaki M, Sugimoto H, Xie L, Hamano Y, Lee SB, Gattone VH, Parry S, Strauss JF, Garovic VD, McElrath TF, Lu KH, Sibai BM, LeBleu VS, Carmeliet P, Kalluri R. Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice. J Clin Invest. 2018 11 01; 128(11):5008-5017. PMID: 30179860; PMCID: PMC6205389.
      Citations: 12     Fields:    Translation:Animals
    36. Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Kalluri R, Saur D. Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program. EMBO Mol Med. 2018 10; 10(10). PMID: 30120146; PMCID: PMC6180301.
      Citations: 32     Fields:    Translation:Animals
    37. Becker LM, LeBleu VS. Endoglin Targeting in Colorectal Tumor Microenvironment. Clin Cancer Res. 2018 12 15; 24(24):6110-6111. PMID: 30076135.
      Citations: 1     Fields:    Translation:HumansCells
    38. Eikesdal HP, Becker LM, Teng Y, Kizu A, Carstens JL, Kanasaki K, Sugimoto H, LeBleu VS, Kalluri R. BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis. Mol Cancer Res. 2018 10; 16(10):1568-1578. PMID: 29934328; PMCID: PMC6170697.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    39. LeBleu VS, Kalluri R. A peek into cancer-associated fibroblasts: origins, functions and translational impact. Dis Model Mech. 2018 04 19; 11(4). PMID: 29686035; PMCID: PMC5963854.
      Citations: 173     Fields:    Translation:HumansAnimalsCells
    40. Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, Marszalek JR, Maitra A, Yee C, Rezvani K, Shpall E, LeBleu VS, Kalluri R. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight. 2018 04 19; 3(8). PMID: 29669940; PMCID: PMC5931131.
      Citations: 203     Fields:    Translation:AnimalsCells
    41. Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Melo SA, Lee JJ, Kalluri R, Ruivo CF. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017 06 22; 546(7659):498-503. PMID: 28607485; PMCID: PMC5538883.
      Citations: 667     Fields:    Translation:AnimalsCells
    42. Carstens JL, Correa de Sampaio P, Yang D, Barua S, Wang H, Rao A, Allison JP, LeBleu VS, Kalluri R. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer. Nat Commun. 2017 04 27; 8:15095. PMID: 28447602; PMCID: PMC5414182.
      Citations: 191     Fields:    Translation:HumansAnimalsCells
    43. Kalluri R, LeBleu VS. Discovery of Double-Stranded Genomic DNA in Circulating Exosomes. Cold Spring Harb Symp Quant Biol. 2016; 81:275-280. PMID: 28424339.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    44. Yang S, Che SP, Kurywchak P, Tavormina JL, Gansmo LB, Correa de Sampaio P, Tachezy M, Bockhorn M, Gebauer F, Haltom AR, LeBleu VS, Kalluri R, Melo SA. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. Cancer Biol Ther. 2017 03 04; 18(3):158-165. PMID: 28121262; PMCID: PMC5389423.
      Citations: 83     Fields:    Translation:HumansCells
    45. Kim J, de Sampaio PC, Lundy DM, Peng Q, Evans KW, Sugimoto H, Gagea M, Kienast Y, Eikesdal HP, Meric-Bernstam F, LeBleu VS, Amaral NSD, Rocha RM, L?nning PE. Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. JCI Insight. 2016 Dec 22; 1(21):e90733. PMID: 28018977; PMCID: PMC5161212.
      Citations: 10     Fields:    
    46. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 05; 22(5):497-505. PMID: 27089513; PMCID: PMC4860133.
      Citations: 240     Fields:    Translation:HumansAnimalsCells
    47. Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R, ?zdemir BC. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 2015 Dec 14; 28(6):831-833. PMID: 28843279.
      Citations: 74     Fields:    
    48. Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH. Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. J Proteome Res. 2015 Dec 04; 14(12):5252-62. PMID: 26595531; PMCID: PMC4768904.
      Citations: 22     Fields:    Translation:AnimalsCells
    49. Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015 Nov 26; 527(7579):525-530. PMID: 26560028; PMCID: PMC4849281.
      Citations: 972     Fields:    Translation:Animals
    50. Lovisa S, LeBleu VS, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Pentcheva-Hoang T, Nischal H, Allison JP, Kalluri R, Tampe B, Hagos Y, Burckhardt BC, Zeisberg M. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med. 2015 Sep; 21(9):998-1009. PMID: 26236991; PMCID: PMC4587560.
      Citations: 322     Fields:    Translation:HumansAnimalsCells
    51. Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Fraga MF, Piwnica-Worms D, Kalluri R, Weitz J, Rahbari N, Reissfelder C, Pilarsky C. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015 Jul 09; 523(7559):177-82. PMID: 26106858; PMCID: PMC4825698.
      Citations: 969     Fields:    Translation:HumansAnimalsCells
    52. LeBleu VS. Imaging the Tumor Microenvironment. Cancer J. 2015 May-Jun; 21(3):174-8. PMID: 26049696; PMCID: PMC4498162.
      Citations: 18     Fields:    Translation:Humans
    53. Keskin D, Kim J, Cooke VG, Wu CC, Sugimoto H, Gu C, Kalluri R, LeBleu VS, De Palma M. Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep. 2015 Feb 24; 10(7):1066-81. PMID: 25704811; PMCID: PMC4342328.
      Citations: 72     Fields:    Translation:AnimalsCells
    54. LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote?metastasis. Nat Cell Biol. 2014 Oct; 16(10):992-1003, 1-15. PMID: 25241037; PMCID: PMC4369153.
      Citations: 558     Fields:    Translation:HumansAnimalsCells
    55. LeBleu V, Kalluri R, Zeisberg M, Tampe B, Tampe D, Zeisberg EM. Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure. Am J Pathol. 2014 Oct; 184(10):2687-98. PMID: 25111226; PMCID: PMC4715225.
      Citations: 12     Fields:    Translation:Animals
    56. Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Allison JP, ?zdemir BC, Sugimoto H, Kahlert C, Maitra A, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014 Jun 16; 25(6):719-34. PMID: 24856586; PMCID: PMC4180632.
      Citations: 944     Fields:    Translation:HumansAnimalsCells
    57. Tampe D, Sugimoto H, LeBleu V, Kalluri R, Zeisberg M, Tampe B, M?ller CA, Xu X, M?ller GA, Zeisberg EM. Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis. J Am Soc Nephrol. 2014 May; 25(5):905-12. PMID: 24480825; PMCID: PMC4005308.
      Citations: 56     Fields:    Translation:AnimalsCells
    58. Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe D, Kanasaki K, Zeisberg M, Kalluri R, Tampe B. Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med. 2013 Jul; 19(7):810-1. PMID: 23836214.
      Citations: 2     Fields:    Translation:Animals
    59. LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013 Aug; 19(8):1047-53. PMID: 23817022; PMCID: PMC4067127.
      Citations: 525     Fields:    Translation:AnimalsCells
    60. LeBleu VS, Teng Y, O'Connell JT, Charytan D, Sugimoto H, Kalluri R, M?ller GA, M?ller CA. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. Nat Med. 2013 Feb; 19(2):227-31. PMID: 23353556; PMCID: PMC4457508.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    61. Borges FT, Melo SA, Kato N, Revuelta I, Miller CA, Gattone VH, LeBleu VS, Kalluri R, ?zdemir BC. TGF-?1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis. J Am Soc Nephrol. 2013 Feb; 24(3):385-92. PMID: 23274427; PMCID: PMC3582210.
      Citations: 172     Fields:    Translation:HumansAnimalsCells
    62. Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe D, Kanasaki K, Zeisberg M, Kalluri R, Tampe B. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012 Feb 05; 18(3):396-404. PMID: 22306733; PMCID: PMC3998727.
      Citations: 109     Fields:    Translation:AnimalsCells
    63. Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell. 2012 Jan 17; 21(1):66-81. PMID: 22264789; PMCID: PMC3999522.
      Citations: 229     Fields:    Translation:HumansAnimalsCells
    64. LeBleu VS, Kalluri R. Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis. Kidney Int. 2011 Dec; 80(11):1119-21. PMID: 22083636; PMCID: PMC4316679.
      Citations: 13     Fields:    Translation:AnimalsCells
    65. De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K, Maertens O. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011 Sep 13; 20(3):400-13. PMID: 21907929; PMCID: PMC3233475.
      Citations: 130     Fields:    Translation:AnimalsCells
    66. O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, Neilson EG, Zeisberg M, Kalluri R. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16002-7. PMID: 21911392; PMCID: PMC3179047.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    67. LeBleu V, Sund M, Sugimoto H, Birrane G, Kanasaki K, Finan E, Miller CA, Gattone VH, McLaughlin H, Shield CF, Kalluri R. Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly. J Biol Chem. 2010 Dec 31; 285(53):41874-85. PMID: 20847057; PMCID: PMC3009915.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    68. LeBleu V, Sugimoto H, Mundel TM, Gerami-Naini B, Finan E, Miller CA, Gattone VH, Lu L, Shield CF, Folkman J, Kalluri R. Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol. 2009 Nov; 20(11):2359-70. PMID: 19833902; PMCID: PMC2799182.
      Citations: 26     Fields:    Translation:AnimalsCells
    69. Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science. 2009 Jul 10; 325(5937):167-71. PMID: 19589995; PMCID: PMC2905160.
      Citations: 167     Fields:    Translation:AnimalsCells
    70. Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, Asara JM. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science. 2009 May 01; 324(5927):626-31. PMID: 19407199.
      Citations: 59     Fields:    Translation:AnimalsCells
    71. LeBleu VS, Kalluri R. Stem cell-based therapy for glomerular diseases: an evolving concept. J Am Soc Nephrol. 2008 Sep; 19(9):1621-3. PMID: 18701605.
      Citations: 4     Fields:    Translation:Animals
    72. Lebleu VS, Sugimoto H, Miller CA, Gattone VH, Kalluri R. Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease. Lab Invest. 2008 Mar; 88(3):284-92. PMID: 18180701.
      Citations: 20     Fields:    Translation:AnimalsCells
    73. Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH, Kalluri R. Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008 Jan 15; 313(2):584-93. PMID: 18082680; PMCID: PMC3947521.
      Citations: 73     Fields:    Translation:AnimalsCells
    74. LeBleu VS, Macdonald B, Kalluri R. Structure and function of basement membranes. Exp Biol Med (Maywood). 2007 Oct; 232(9):1121-9. PMID: 17895520.
      Citations: 171     Fields:    Translation:HumansAnimals
    75. Lebleu VS, Thornton M, Gonda SR, Helmstetter CE. Technology for cell cycle research with unstressed steady-state cultures. Cytotechnology. 2006 Jul; 51(3):149-57. PMID: 19002885; PMCID: PMC3449808.
      Citations: 4     Fields:    
    76. Sugimoto H, Yang C, LeBleu VS, Soubasakos MA, Giraldo M, Zeisberg M, Kalluri R. BMP-7 functions as a novel hormone to facilitate liver regeneration. FASEB J. 2007 Jan; 21(1):256-64. PMID: 17116741.
      Citations: 37     Fields:    Translation:HumansAnimals
    77. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine. 22:497-505.
    78. Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. Journal of Proteome Research. 14:5252-5262.
    79. Erratum. Nature Cell Biology. 16:1125.
    80. Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure. American Journal of Pathology. 184:2687-2698.
    81. Imaging the tumor microenvironment. Cancer Journal (United States). 21:174-178.
    82. Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]. Cancer Cell. 28:831-833.
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