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JIAN CHEN

TitleAssistant Professor
InstitutionMD Anderson
DepartmentGastroenterology Hepatology & Nutrition
Address7435 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen JD. Parasympathetic control of gastrointestinal motility and cross-branch actions of parasympathetic neuromodulation. Chin Med J (Engl). 2023 01 05; 136(1):53-55. PMID: 36878003; PMCID: PMC10106197.
      Citations:    Fields:    
    2. Yang H, Yang H, Wang L, Shi H, Liu B, Lin X, Chang Q, Chen JDZ, Duan Z. Transcutaneous Neuromodulation improved inflammation and sympathovagal ratio in patients with primary biliary ssscholangitis and inadequate response to Ursodeoxycholic acid: a pilot study. BMC Complement Med Ther. 2020 Aug 01; 20(1):242. PMID: 32738911; PMCID: PMC7395375.
      Citations: 1     Fields:    Translation:Humans
    3. Tian M, Alimujiang M, Chen JD. Ameliorating Effects and Mechanisms of Intra-Operative Vagal Nerve Stimulation on Postoperative Recovery After Sleeve Gastrectomy in Rats. Obes Surg. 2020 Aug; 30(8):2980-2987. PMID: 32318995.
      Citations:    Fields:    Translation:HumansAnimals
    4. Chen J, Mitra A, Li S, Song S, Nguyen BN, Chen JS, Shin JH, Gough NR, Lin P, Obias V, He AR, Yao Z, Malta TM, Noushmehr H, Latham PS, Su X, Rashid A, Mishra B, Wu RC, Mishra L. Targeting the E3 Ubiquitin Ligase PJA1 Enhances Tumor-Suppressing TGF? Signaling. Cancer Res. 2020 05 01; 80(9):1819-1832. PMID: 32127355; PMCID: PMC7704101.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    5. Yin J, Ji F, Gharibani P, Chen JD. Vagal Nerve Stimulation for Glycemic Control in a Rodent Model of Type 2 Diabetes. Obes Surg. 2019 09; 29(9):2869-2877. PMID: 31222497; PMCID: PMC10461220.
      Citations: 13     Fields:    Translation:Animals
    6. Chen J, Gingold JA, Su X. Immunomodulatory TGF-? Signaling in Hepatocellular Carcinoma. Trends Mol Med. 2019 11; 25(11):1010-1023. PMID: 31353124.
      Citations: 64     Fields:    Translation:HumansCells
    7. Jiang L, Zhang N, Zhang S, Chen JD. Sacral nerve stimulation with optimized parameters improves visceral hypersensitivity in rats mediated via the autonomic pathway. Mol Pain. 2019 Jan-Dec; 15:1744806919880651. PMID: 31530213; PMCID: PMC6775554.
      Citations: 4     Fields:    Translation:Animals
    8. Zhang B, Xu F, Hu P, Zhang M, Tong K, Ma G, Xu Y, Zhu L, Chen JDZ. Needleless Transcutaneous Electrical Acustimulation: A?Pilot Study Evaluating Improvement in Post-Operative Recovery. Am J Gastroenterol. 2018 07; 113(7):1026-1035. PMID: 29925916.
      Citations: 10     Fields:    Translation:Humans
    9. Ge Z, Duan Z, Yang H, Zhang S, Zhang S, Wang L, Yang D, Sun X, Zhang Z, Su L, Zhu H, Zhou D, Liu B, Shi H, Yu J, Yang H, Chang Q, Zhang N, Wu D, Chen JDZ. Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids. Evid Based Complement Alternat Med. 2018; 2018:2086163. PMID: 29853946; PMCID: PMC5949156.
      Citations: 2     
    10. Maybauer DM, Chen JD, Fraser JF, Toon MH, Przkora R, Jennings K, Maybauer MO, Asmussen S. Effects of Acupuncture in Anesthesia for Craniotomy: A Meta-Analysis. J Neurosurg Anesthesiol. 2017 Jul; 29(3):219-227. PMID: 26967459.
      Citations: 14     Fields:    Translation:Humans
    11. Li S, Zhu W, Zhang S, Chen JDZ. Chronic intestinal electrical stimulation improves glucose intolerance and insulin resistance in diet-induced obesity rats. Obesity (Silver Spring). 2017 06; 25(6):1061-1068. PMID: 28437585.
      Citations: 3     Fields:    Translation:Animals
    12. Chen J, Herlong FH, Stroehlein JR, Mishra L. Mutations of Chromatin Structure Regulating Genes in Human Malignancies. Curr Protein Pept Sci. 2016; 17(5):411-37. PMID: 26796307; PMCID: PMC5403969.
      Citations: 6     Fields:    Translation:HumansCells
    13. Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014 Nov 14; 5:5384. PMID: 25395170; PMCID: PMC4234183.
      Citations: 37     Fields:    Translation:AnimalsCells
    14. Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst. 2014 Jul; 106(7). PMID: 24957076; PMCID: PMC4110474.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    15. Zhang Y, Du S, Fang L, Yao S, Chen JD. Retrograde gastric electrical stimulation suppresses calorie intake in obese subjects. Obesity (Silver Spring). 2014 Jun; 22(6):1447-51. PMID: 24273197.
      Citations: 7     Fields:    Translation:Humans
    16. Katz LH, Li Y, Chen JS, Majumdar A, Chen J, Mishra L, Mu?oz NM. Targeting TGF-? signaling in cancer. Expert Opin Ther Targets. 2013 Jul; 17(7):743-60. PMID: 23651053; PMCID: PMC3745214.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    17. Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle. 2012 Nov 15; 11(22):4181-90. PMID: 23095642; PMCID: PMC3524214.
      Citations: 21     Fields:    Translation:HumansCells
    18. Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):E1513-22. PMID: 22611192; PMCID: PMC3386093.
      Citations: 78     Fields:    Translation:HumansCells
    19. Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, Yeung SC, Lee MH. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3s. Oncogene. 2011 Dec 01; 30(48):4791-801. PMID: 21625211; PMCID: PMC3358116.
      Citations: 38     Fields:    Translation:HumansCells
    20. Feng YH, Velazquez-Torres G, Gully C, Chen J, Lee MH, Yeung SC. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med. 2011 Apr; 15(4):825-36. PMID: 20455996; PMCID: PMC2930937.
      Citations: 33     Fields:    Translation:HumansCells
    21. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011 Mar; 121(3):851-65. PMID: 21317535; PMCID: PMC3049400.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    22. Zhao R, Fuentes-Mattei E, Velazquez-Torres G, Su CH, Chen J, Lee MH, Yeung SC. Exenatide improves glucocorticoid-induced glucose intolerance in mice. Diabetes Metab Syndr Obes. 2011 Jan 26; 4:61-5. PMID: 21448323; PMCID: PMC3064408.
      Citations: 7     
    23. Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH. 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res. 2011 Feb 01; 71(3):884-94. PMID: 21135113; PMCID: PMC3358120.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    24. Su CH, Zhao R, Velazquez-Torres G, Chen J, Gully C, Yeung SC, Lee MH. Nuclear export regulation of COP1 by 14-3-3s in response to DNA damage. Mol Cancer. 2010 Sep 15; 9:243. PMID: 20843328; PMCID: PMC2949799.
      Citations: 23     Fields:    Translation:HumansCells
    25. Wang J, Song J, Hou X, Liu J, Chen JD. Effects of cutaneous gastric electrical stimulation on gastric emptying and postprandial satiety and fullness in lean and obese subjects. J Clin Gastroenterol. 2010 May-Jun; 44(5):335-9. PMID: 20195164.
      Citations: 6     Fields:    Translation:Humans
    26. Gully CP, Zhang F, Chen J, Yeung JA, Velazquez-Torres G, Wang E, Yeung SC, Lee MH. Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer. 2010 Feb 22; 9:42. PMID: 20175926; PMCID: PMC2839967.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    27. Yin J, Chen JD. Mechanisms and potential applications of intestinal electrical stimulation. Dig Dis Sci. 2010 May; 55(5):1208-20. PMID: 19629689.
      Citations: 16     Fields:    Translation:HumansAnimals
    28. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. Am J Pathol. 2009 Jul; 175(1):400-11. PMID: 19528349; PMCID: PMC2708825.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    29. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH. Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene. 2009 Jul 16; 28(28):2581-92. PMID: 19483729; PMCID: PMC3358117.
      Citations: 43     Fields:    Translation:HumansCells
    30. Yin J, Chen JD. Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies. J Cell Mol Med. 2008 Aug; 12(4):1118-29. PMID: 18429936; PMCID: PMC3865654.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    31. Zhang XC, Chen J, Su CH, Yang HY, Lee MH. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 2008 Mar 01; 103(4):1219-30. PMID: 17879958.
      Citations: 44     Fields:    Translation:HumansCells
    32. Yin J, Chen JDz. Excitatory effects of synchronized intestinal electrical stimulation on small intestinal motility in dogs. Am J Physiol Gastrointest Liver Physiol. 2007 Dec; 293(6):G1190-5. PMID: 17916650.
      Citations: 12     Fields:    Translation:Animals
    33. Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuchi T, Kobayashi M. All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors. J Immunol. 2007 Oct 01; 179(7):4616-25. PMID: 17878359.
      Citations: 25     Fields:    Translation:AnimalsCells
    34. Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui HY, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, Kobayashi M. Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. Cancer Gene Ther. 2007 Jan; 14(1):39-44. PMID: 16841081.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    35. Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada J, Hattori Y, Kondo T, Hamuro J, Asaka M, Kobayashi M. Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells. Eur J Immunol. 2005 Dec; 35(12):3468-77. PMID: 16259004.
      Citations: 15     Fields:    Translation:HumansCells
    36. Suzuki A, Kusakai G, Shimojo Y, Chen J, Ogura T, Kobayashi M, Esumi H. Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation. J Biol Chem. 2005 Sep 09; 280(36):31557-63. PMID: 16014625.
      Citations: 18     Fields:    Translation:HumansCells
    37. Yao S, Ke M, Wang Z, Xu D, Zhang Y, Chen JD. Visceral sensitivity to gastric stimulation and its correlation with alterations in gastric emptying and accommodation in humans. Obes Surg. 2005 Feb; 15(2):247-53. PMID: 15802069.
      Citations: 10     Fields:    Translation:Humans
    38. Chiba K, Zhao W, Chen J, Wang J, Cui HY, Kawakami H, Miseki T, Satoshi H, Tanaka J, Asaka M, Kobayashi M. Neutrophils secrete MIP-1 beta after adhesion to laminin contained in basement membrane of blood vessels. Br J Haematol. 2004 Dec; 127(5):592-7. PMID: 15566363.
      Citations: 12     Fields:    Translation:HumansCells
    39. Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R, Kanangi R. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8132-7. PMID: 15141079; PMCID: PMC419569.
      Citations: 96     Fields:    Translation:HumansCells
    40. Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, Sugiyama T, Hosokawa M, Kobayashi M. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol. 2003 Apr; 162(4):1283-91. PMID: 12651620; PMCID: PMC1851236.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    41. Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M. Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis. Oncogene. 2003 Feb 27; 22(8):1238-42. PMID: 12606950.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    42. Chen J. [Dominant negative HIF-1 alpha reduces tumorigenicity of a human pancreatic cancer cell line]. Hokkaido Igaku Zasshi. 2002 Jul; 77(4):367-78. PMID: 12187833.
      Citations:    Fields:    Translation:HumansAnimalsCells
    43. Niizeki H, Kobayashi M, Horiuchi I, Akakura N, Chen J, Wang J, Hamada JI, Seth P, Katoh H, Watanabe H, Raz A, Hosokawa M. Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells. Br J Cancer. 2002 Jun 17; 86(12):1914-9. PMID: 12085186; PMCID: PMC2375441.
      Citations: 30     Fields:    Translation:HumansCells
    44. Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Hosokawa M, Asaka M. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res. 2001 Sep 01; 61(17):6548-54. PMID: 11522653.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    45. Nature Communications. 6.
    46. The landscape of DNA virus associations across human cancers. 303-316.
    47. Mutations of chromatin structure regulating genes in human malignancies. Current Protein and Peptide Science. 17:411-437.
    48. Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption. Genes and Cancer. 5:348-352.
    49. TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. Journal of Clinical Investigation. 126:527-542.
    50. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 101:10494.
    51. Pathogenesis of hepatocellular carcinoma development in non-alcoholic fatty liver disease. Current Hepatitis Reports. 14:119-127.
    52. Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation. Scientific Reports. 6.
    53. CSN6 positively regulates c-jun in a MEKK1-dependent manner. Cell Cycle. 14:3079-3087.
    54. Mutational profiles reveal an aberrant TGF-β-CEA regulated pathway in colon adenomas. PLoS One. 11.
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