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TOMASZ ZAL

TitleAssociate Professor
InstitutionMD Anderson
DepartmentImmunology
Address7455 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Patel B, Zhou Y, Babcock RL, Ma F, Zal MA, Kumar D, Medik YB, Kahn LM, Pineda JE, Park EM, Schneider SM, Tang X, Raso MG, Jeter CR, Zal T, Clise-Dwyer K, Keyomarsi K, Giancotti FG, Colla S, Watowich SS. STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response. Leukemia. 2024 Mar 11. PMID: 38467768.
      Citations:    Fields:    
    2. Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I. Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Cancer Discov. 2023 07 07; 13(7):1656-1677. PMID: 37088914; PMCID: PMC10330144.
      Citations:    Fields:    Translation:HumansCells
    3. Jia Y, Zhang W, Basyal M, Chang KH, Ostermann L, Burks JK, Ly C, Mu-Mosley H, Zhang Q, Han X, Fogler WE, Magnani JL, Lesegretain A, Zal AA, Zal T, Andreeff M. FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML. Leukemia. 2023 06; 37(6):1379-1383. PMID: 37085610; PMCID: PMC10244167.
      Citations:    Fields:    Translation:HumansCells
    4. Patel B, Zhou Y, Babcock RL, Ma F, Zal MA, Kumar D, Medik YB, Kahn LM, Pineda JE, Park EM, Tang X, Raso MG, Zal T, Clise-Dwyer K, Giancotti FG, Colla S, Watowich SS. STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity. bioRxiv. 2023 Feb 11. PMID: 36798265; PMCID: PMC9934695.
      Citations:    
    5. Shim HS, Horner JW, Wu CJ, Li J, Lan ZD, Jiang S, Xu X, Hsu WH, Zal T, Flores II, Deng P, Lin YT, Tsai LH, Wang YA, DePinho RA. Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models. Nat Aging. 2021 12; 1(12):1162-1174. PMID: 35036927; PMCID: PMC8759755.
      Citations:    
    6. Henderson J, Havranek O, Ma MCJ, Herman V, Kupcova K, Chrbolkova T, Pacheco-Blanco M, Wang Z, Comer JM, Zal T, Davis RE. Detecting F?rster resonance energy transfer in living cells by conventional and spectral flow cytometry. Cytometry A. 2022 Oct; 101(10):818-834. PMID: 34128311.
      Citations: 1     Fields:    
    7. Han S, Zal T, Sokolov KV. Fate of Antibody-Targeted Ultrasmall Gold Nanoparticles in Cancer Cells after Receptor-Mediated Uptake. ACS Nano. 2021 06 22; 15(6):9495-9508. PMID: 34011152; PMCID: PMC8223898.
      Citations: 1     Fields:    
    8. Rytelewski M, Harutyunyan K, Baran N, Mallampati S, Zal MA, Cavazos A, Butler JM, Konoplev S, El Khatib M, Plunkett S, Marszalek JR, Andreeff M, Zal T, Konopleva M. Inhibition of Oxidative Phosphorylation Reverses Bone Marrow Hypoxia Visualized in Imageable Syngeneic B-ALL Mouse Model. Front Oncol. 2020; 10:991. PMID: 32695673; PMCID: PMC7339962.
      Citations: 6     
    9. Rytelewski M, Haryutyunan K, Nwajei F, Shanmugasundaram M, Wspanialy P, Zal MA, Chen CH, El Khatib M, Plunkett S, Vinogradov SA, Konopleva M, Zal T. Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors. J Immunother Cancer. 2019 03 18; 7(1):78. PMID: 30885258; PMCID: PMC6423744.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    10. Jayaprakash P, Ai M, Liu A, Budhani P, Bartkowiak T, Sheng J, Ager C, Nicholas C, Jaiswal AR, Sun Y, Shah K, Balasubramanyam S, Li N, Wang G, Ning J, Zal A, Zal T, Curran MA. Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy. J Clin Invest. 2018 11 01; 128(11):5137-5149. PMID: 30188869; PMCID: PMC6205399.
      Citations: 125     Fields:    Translation:AnimalsCells
    11. Chodaczek G, Toporkiewicz M, Zal MA, Zal T. Epidermal T Cell Dendrites Serve as Conduits for Bidirectional Trafficking of Granular Cargo. Front Immunol. 2018; 9:1430. PMID: 29988392; PMCID: PMC6023976.
      Citations: 5     Fields:    
    12. Gabrusiewicz K, Li X, Wei J, Hashimoto Y, Marisetty AL, Ott M, Wang F, Hawke D, Yu J, Healy LM, Hossain A, Akers JC, Maiti SN, Yamashita S, Shimizu Y, Dunner K, Zal MA, Burks JK, Gumin J, Nwajei F, Rezavanian A, Zhou S, Rao G, Sawaya R, Fuller GN, Huse JT, Antel JP, Li S, Cooper L, Sulman EP, Chen C, Geula C, Kalluri R, Zal T, Heimberger AB. Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes. Oncoimmunology. 2018; 7(4):e1412909. PMID: 29632728; PMCID: PMC5889290.
      Citations: 122     Fields:    
    13. Havranek O, Xu J, Wang Z, Becker L, Comer JM, Henderson J, Ma W, Man Chun Ma J, Westin JR, Ghosh D, Shinners N, Sun L, Yi AF, Karri AR, Burger JA, Zal T, Davis RE, K?hrer S. Tonic B-cell receptor signaling in diffuse large B-cell lymphoma. Blood. 2017 08 24; 130(8):995-1006. PMID: 28646116; PMCID: PMC5813722.
      Citations: 30     Fields:    Translation:HumansCells
    14. Tan X, Banerjee P, Guo HF, Ireland S, Pankova D, Ahn YH, Nikolaidis IM, Liu X, Zhao Y, Xue Y, Burns AR, Roybal J, Gibbons DL, Zal T, Creighton CJ, Ungar D, Wang Y, Kurie JM. Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11. J Clin Invest. 2017 01 03; 127(1):117-131. PMID: 27869652; PMCID: PMC5199715.
      Citations: 39     Fields:    Translation:HumansCells
    15. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015 Mar 02; 125(3):1147-62. PMID: 25664850; PMCID: PMC4362236.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    16. Yu J, Zhou X, Chang M, Nakaya M, Chang JH, Xiao Y, Lindsey JW, Dorta-Estremera S, Cao W, Zal A, Zal T, Sun SC. Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nat Commun. 2015 Jan 21; 6:6074. PMID: 25606824; PMCID: PMC4302769.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    17. Schietinger A, Arina A, Liu RB, Wells S, Huang J, Engels B, Bindokas V, Bartkowiak T, Lee D, Herrmann A, Piston DW, Pittet MJ, Lin PC, Zal T, Schreiber H. Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer. Oncoimmunology. 2013 Nov 01; 2(11):e26677. PMID: 24482750; PMCID: PMC3895414.
      Citations: 25     Fields:    
    18. Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-?B activation through deubiquitination of TRAF3. Nature. 2013 Feb 21; 494(7437):371-4. PMID: 23334419; PMCID: PMC3578967.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    19. Bhatnagar P, Li Z, Choi Y, Guo J, Li F, Lee DY, Figliola M, Huls H, Lee DA, Zal T, Li KC, Cooper LJ. Imaging of genetically engineered T cells by PET using gold nanoparticles complexed to Copper-64. Integr Biol (Camb). 2013 Jan; 5(1):231-8. PMID: 23034721; PMCID: PMC3713485.
      Citations: 16     Fields:    Translation:AnimalsCells
    20. Nevozhay D, Zal T, Bal?zsi G. Transferring a synthetic gene circuit from yeast to mammalian cells. Nat Commun. 2013; 4:1451. PMID: 23385595; PMCID: PMC3573884.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    21. Ariotti S, Beltman JB, Chodaczek G, Hoekstra ME, van Beek AE, Gomez-Eerland R, Ritsma L, van Rheenen J, Zal T, de Boer RJ, Haanen JB, Schumacher TN, Mar?e AF. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19739-44. PMID: 23150545; PMCID: PMC3511734.
      Citations: 120     Fields:    Translation:HumansCells
    22. Hirve N, Levytskyy RM, Rigaud S, Guimond DM, Zal T, Sauer K, Tsoukas CD. A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions. PLoS One. 2012; 7(9):e45158. PMID: 23028816; PMCID: PMC3445557.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    23. Talukder AH, Bao M, Kim TW, Facchinetti V, Hanabuchi S, Bover L, Zal T, Liu YJ. Phospholipid scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Cell Res. 2012 Jul; 22(7):1129-39. PMID: 22453241; PMCID: PMC3391020.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    24. Chodaczek G, Papanna V, Zal MA, Zal T. Body-barrier surveillance by epidermal ?d TCRs. Nat Immunol. 2012 Feb 12; 13(3):272-82. PMID: 22327568; PMCID: PMC3288780.
      Citations: 92     Fields:    Translation:AnimalsCells
    25. Zal T. Visualization of Protein Interactions in Living Cells. Self Nonself. 2011 Apr; 2(2):98-107. PMID: 22299061; PMCID: PMC3268995.
      Citations: 1     
    26. Zal T, Chodaczek G. Intravital imaging of anti-tumor immune response and the tumor microenvironment. Semin Immunopathol. 2010 Sep; 32(3):305-17. PMID: 20652252; PMCID: PMC2971683.
      Citations: 9     Fields:    Translation:AnimalsCells
    27. Gascoigne NR, Zal T, Yachi PP, Hoerter JA. Co-receptors and recognition of self at the immunological synapse. Curr Top Microbiol Immunol. 2010; 340:171-89. PMID: 19960314; PMCID: PMC5788015.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    28. Rostro-Kohanloo BC, Bickford LR, Payne CM, Day ES, Anderson LJ, Zhong M, Lee S, Mayer KM, Zal T, Adam L, Dinney CP, Drezek RA, West JL, Hafner JH. The stabilization and targeting of surfactant-synthesized gold nanorods. Nanotechnology. 2009 Oct 28; 20(43):434005. PMID: 19801751.
      Citations: 20     Fields:    Translation:HumansCells
    29. Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, Homey B, Barrat FJ, Zal T, Gilliet M. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med. 2009 Aug 31; 206(9):1983-94. PMID: 19703986; PMCID: PMC2737167.
      Citations: 254     Fields:    Translation:HumansCells
    30. Ma LJ, Acero LF, Zal T, Schluns KS. Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J Immunol. 2009 Jul 15; 183(2):1044-54. PMID: 19553528; PMCID: PMC2706935.
      Citations: 63     Fields:    Translation:AnimalsCells
    31. Gascoigne NR, Ampudia J, Clamme JP, Fu G, Lotz C, Mallaun M, Niederberger N, Palmer E, Rybakin V, Yachi PP, Zal T. Visualizing intermolecular interactions in T cells. Curr Top Microbiol Immunol. 2009; 334:31-46. PMID: 19521680; PMCID: PMC3079427.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    32. Chamilos G, Lewis RE, Hu J, Xiao L, Zal T, Gilliet M, Halder G, Kontoyiannis DP. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9367-72. PMID: 18583479; PMCID: PMC2453716.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    33. Zal T. Visualization of protein interactions in living cells. Adv Exp Med Biol. 2008; 640:183-97. PMID: 19065792; PMCID: PMC5788009.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    34. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Liu YJ, Gilliet M, Schr?der JM. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007 Oct 04; 449(7162):564-9. PMID: 17873860.
      Citations: 662     Fields:    Translation:HumansCells
    35. Zal T, Zal MA, Lotz C, Goergen CJ, Gascoigne NR. Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells. Traffic. 2006 Dec; 7(12):1607-13. PMID: 17052249.
      Citations: 4     Fields:    Translation:Cells
    36. Zambricki E, Zal T, Yachi P, Shigeoka A, Sprent J, Gascoigne N, McKay D. In vivo anergized T cells form altered immunological synapses in vitro. Am J Transplant. 2006 Nov; 6(11):2572-9. PMID: 16952297.
      Citations: 10     Fields:    Translation:AnimalsCells
    37. Yachi PP, Ampudia J, Zal T, Gascoigne NR. Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality. Immunity. 2006 Aug; 25(2):203-11. PMID: 16872849.
      Citations: 63     Fields:    Translation:Cells
    38. Wirz SA, Davis CN, Lu X, Zal T, Bartfai T. Homodimerization and internalization of galanin type 1 receptor in living CHO cells. Neuropeptides. 2005 Dec; 39(6):535-46. PMID: 16242774.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Yachi PP, Ampudia J, Gascoigne NR, Zal T. Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol. 2005 Aug; 6(8):785-92. PMID: 15980863; PMCID: PMC1352171.
      Citations: 73     Fields:    Translation:HumansCells
    40. Lin MY, Zal T, Ch'en IL, Gascoigne NR, Hedrick SM. A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. J Immunol. 2005 May 01; 174(9):5583-92. PMID: 15843557.
      Citations: 26     Fields:    Translation:AnimalsCells
    41. Zal T, Gascoigne NR. Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol. 2004 Oct; 16(5):674-83. PMID: 15818893.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    42. Zal T, Gascoigne NR. Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr Opin Immunol. 2004 Aug; 16(4):418-27. PMID: 15245734.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    43. Zal T, Gascoigne NR. Photobleaching-corrected FRET efficiency imaging of live cells. Biophys J. 2004 Jun; 86(6):3923-39. PMID: 15189889; PMCID: PMC1304294.
      Citations: 160     Fields:    Translation:AnimalsCells
    44. Gascoigne NR, Zal T. Molecular interactions at the T cell-antigen-presenting cell interface. Curr Opin Immunol. 2004 Feb; 16(1):114-9. PMID: 14734119.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. Huang J, Lo PF, Zal T, Gascoigne NR, Smith BA, Levin SD, Grey HM. CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9369-73. PMID: 12077322; PMCID: PMC123147.
      Citations: 64     Fields:    Translation:AnimalsCells
    46. Gascoigne NR, Zal T, Alam SM. T-cell receptor binding kinetics in T-cell development and activation. Expert Rev Mol Med. 2001 Feb 12; 2001:1-17. PMID: 14987373.
      Citations: 46     Fields:    
    47. Gascoigne NR, Alam SM, Lin CM, McGuire MV, Marine S, Niederberger N, Redpath S, Sim BC, Travers PJ, Yachi P, Zal MA, Zal T. T cell receptor binding kinetics and special role of Valpha in T cell development and activation. Immunol Res. 2000; 21(2-3):225-31. PMID: 10852121.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    48. Alam SM, Davies GM, Lin CM, Zal T, Nasholds W, Jameson SC, Hogquist KA, Gascoigne NR, Travers PJ. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity. 1999 Feb; 10(2):227-37. PMID: 10072075.
      Citations: 84     Fields:    Translation:AnimalsCells
    49. Stockinger B, Zal T. T-cells with two T-cell receptors: are they important in autoimmunity? Biochem Soc Trans. 1997 May; 25(2):617-20. PMID: 9191167.
      Citations:    Fields:    Translation:HumansAnimalsCells
    50. Volkmann A, Zal T, Stockinger B. Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen. J Immunol. 1997 Jan 15; 158(2):693-706. PMID: 8992985.
      Citations: 34     Fields:    Translation:AnimalsCells
    51. Zal T, Weiss S, Mellor A, Stockinger B. Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):9102-7. PMID: 8799161; PMCID: PMC38602.
      Citations: 30     Fields:    Translation:AnimalsCells
    52. Stockinger B, Zal T, Zal A, Gray D. B cells solicit their own help from T cells. J Exp Med. 1996 Mar 01; 183(3):891-9. PMID: 8642293; PMCID: PMC2192359.
      Citations: 64     Fields:    Translation:AnimalsCells
    53. Zal T, Volkmann A, Stockinger B. Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen. J Exp Med. 1994 Dec 01; 180(6):2089-99. PMID: 7964486; PMCID: PMC2191800.
      Citations: 105     Fields:    Translation:AnimalsCells
    54. Visualization of protein interactions in living cells. Self/Nonself - Immune Recognition and Signaling. 2:98-107.
    55. Induction of tolerance or (auto) immunity in MHC class II restricted T cells. Immunologist. 6:102-105.
    56. Microblal transformation of azacarbazoles X. Biotechnology Letters. 18:123-128.
    57. Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11. Journal of Clinical Investigation. 127:117-131.
    58. Interleaved dual-wavelength multiphoton imaging system for heterologous FRET and versatile fluorescent protein excitation.
    59. Erratum. Nature Immunology. 13:621.
    60. Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nature Communications. 6.
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