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NAHUM PUEBLA-OSORIO

TitleAssistant Professor
InstitutionMD Anderson
DepartmentLymphoma-Myeloma
Address1515 Holcombe Blvd.
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Puebla-Osorio N, Fowlkes NW, Barsoumian HB, Xega K, Srivastava G, Kettlun-Leyton C, Nizzero S, Voss T, Riad TS, Wong C, Huang A, Hu Y, Mitchell J, Kim M, Rafiq Z, He K, Sezen D, Hsu E, Masrorpour F, Maleki A, Leuschner C, Cortez MA, Oertle P, Loparic M, Plodinec M, Markman JL, Welsh JW. Enhanced tumor control and survival in preclinical models with adoptive cell therapy preceded by low-dose radiotherapy. Front Oncol. 2024; 14:1407143. PMID: 39445067; PMCID: PMC11496962.
      Citations:    
    2. Hu Y, Paris S, Sahoo N, Wang Q, Wang Q, Barsoumian HB, Huang A, Da Silva J, Bienassis C, Leyton CSK, Voss TA, Masrorpour F, Riad T, Leuschner C, Puebla-Osorio N, Gandhi S, Nguyen QN, Wang J, Cortez MA, Welsh JW. Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3. J Nanobiotechnology. 2024 Oct 01; 22(1):597. PMID: 39354474; PMCID: PMC11445951.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. He K, Puebla-Osorio N, Barsoumian HB, Sezen D, Rafq Z, Riad TS, Hu Y, Huang A, Voss TA, Kettlun Leyton CS, Schuda LJ, Hsu E, Heiber J, Cortez MA, Welsh JW. Correction: Novel engineered IL-2 Nemvaleukin alfa combined with PD1 checkpoint blockade enhances the systemic anti-tumor responses of radiation therapy. J Exp Clin Cancer Res. 2024 Sep 10; 43(1):256. PMID: 39256857; PMCID: PMC11386066.
      Citations:    Fields:    
    4. He K, Puebla-Osorio N, Barsoumian HB, Sezen D, Rafiq Z, Riad TS, Hu Y, Huang A, Voss TA, Leyton CSK, Schuda LJ, Hsu E, Heiber J, Cortez MA, Welsh JW, Rafiq Z. Novel engineered IL-2 Nemvaleukin alfa combined with PD1 checkpoint blockade enhances the systemic anti-tumor responses of radiation therapy. J Exp Clin Cancer Res. 2024 Sep 02; 43(1):251. PMID: 39218928; PMCID: PMC11367833.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Rezvan A, Romain G, Fathi M, Heeke D, Martinez-Paniagua M, An X, Bandey IN, Montalvo MJ, Adolacion JRT, Saeedi A, Sadeghi F, Fousek K, Puebla-Osorio N, Cooper LJN, Bernatchez C, Singh H, Ahmed N, Mattie M, Bot A, Neelapu S, Varadarajan N. Author Correction: Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling. Nat Cancer. 2024 Jun; 5(6):954. PMID: 38778179.
      Citations: 1     Fields:    
    6. Rezvan A, Romain G, Fathi M, Heeke D, Martinez-Paniagua M, An X, Bandey IN, Montalvo MJ, Adolacion JRT, Saeedi A, Sadeghi F, Fousek K, Puebla-Osorio N, Cooper LJN, Bernatchez C, Singh H, Ahmed N, Mattie M, Bot A, Neelapu S, Varadarajan N. Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling. Nat Cancer. 2024 Jul; 5(7):1010-1023. PMID: 38750245.
      Citations: 3     Fields:    Translation:HumansCells
    7. Hu Y, Revenko A, Barsoumian H, Bertolet G, Fowlkes NW, Maazi H, Green MM, He K, Sezen D, Voss TA, Leyton CSK, Masrorpour F, Rafiq Z, Puebla-Osorio N, Leuschner C, MacLeod R, Cortez MA, Welsh JW. Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy. J Exp Clin Cancer Res. 2024 Mar 06; 43(1):70. PMID: 38443968; PMCID: PMC10916163.
      Citations:    Fields:    Translation:AnimalsCells
    8. Hu Y, Paris S, Sahoo N, Bertolet G, Wang Q, Wang Q, Barsoumian HB, Da Silva J, Huang A, Doss DJ, Pollock DP, Hsu E, Selene N, Leyton CSK, Voss TA, Masrorpour F, Ganjoo S, Leuschner C, Pietz JT, Puebla-Osorio N, Gandhi S, Nguyen QN, Wang J, Cortez MA, Welsh JW. Nanoparticle-enhanced proton beam immunoradiotherapy drives immune activation and durable tumor rejection. JCI Insight. 2023 06 22; 8(12). PMID: 37345658; PMCID: PMC10371249.
      Citations: 4     Fields:    Translation:Animals
    9. He K, Hong DS, Ke D, Kebriaei P, Wang T, Danesi H, Bertolet G, Leuschner C, Puebla-Osorio N, Voss TA, Lin Q, Norry E, Fracasso PM, Welsh JW. Durable control of metastases in an HLA-A2+ patient with refractory melanoma after low-dose radiotherapy in combination with MAGE-A4 T cell therapy: a case report. Melanoma Res. 2023 08 01; 33(4):332-337. PMID: 37325860; PMCID: PMC10309102.
      Citations:    Fields:    Translation:Humans
    10. He K, Barsoumian HB, Puebla-Osorio N, Hu Y, Sezen D, Wasley MD, Bertolet G, Zhang J, Leuschner C, Yang L, Kettlun Leyton CS, Fowlkes NW, Green MM, Hettrick L, Chen D, Masrorpour F, Gu M, Maazi H, Revenko AS, Cortez MA, Welsh JW. Inhibition of STAT6 with Antisense Oligonucleotides Enhances the Systemic Antitumor Effects of Radiotherapy and Anti-PD-1 in Metastatic Non-Small Cell Lung Cancer. Cancer Immunol Res. 2023 04 03; 11(4):486-500. PMID: 36700864; PMCID: PMC10099280.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Jallouk AP, Gouni S, Westin J, Feng L, Mistry H, Steiner RE, James J, Noorani M, Horowitz S, Puebla-Osorio N, Fayad LE, Iyer SP, Hawkins M, Flowers CR, Ahmed S, Nastoupil LJ, Kebriaei P, Neelapu SS, Nieto Y, Strati P, Shpall EJ. Axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma patients in complete metabolic response. Haematologica. 2023 04 01; 108(4):1163-1167. PMID: 36384251; PMCID: PMC10071112.
      Citations: 2     Fields:    Translation:Humans
    12. Hu Y, Paris S, Bertolet G, Barsoumian HB, Wang Q, Da Silva J, Patel NB, Nguyen N, Doss DJ, Huang A, Hsu E, Leyton CSK, Voss TA, Masrorpour F, Leuschner C, Pietz JT, Puebla-Osorio N, Gandhi S, Nguyen QN, Wang J, Cortez MA, Welsh JW. NBTXR3 improves the efficacy of immunoradiotherapy combining nonfucosylated anti-CTLA4 in an anti-PD1 resistant lung cancer model. Front Immunol. 2022; 13:1022011. PMID: 36405757; PMCID: PMC9669748.
      Citations: 1     Fields:    Translation:Animals
    13. Ganjoo S, Puebla-Osorio N, Nanez S, Hsu E, Voss T, Barsoumian H, Duong LK, Welsh JW, Cortez MA. Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance. Front Immunol. 2022; 13:1033642. PMID: 36353620; PMCID: PMC9638036.
      Citations:    Fields:    
    14. Sezen D, Barsoumian HB, He K, Hu Y, Wang Q, Abana CO, Puebla-Osorio N, Hsu EY, Wasley M, Masrorpour F, Wang J, Cortez MA, Welsh JW. Pulsed radiotherapy to mitigate high tumor burden and generate immune memory. Front Immunol. 2022; 13:984318. PMID: 36275767; PMCID: PMC9582356.
      Citations:    Fields:    Translation:AnimalsCells
    15. Hu Y, Paris S, Bertolet G, Barsoumian HB, He K, Sezen D, Chen D, Wasley M, Silva JD, Mitchell JA, Voss TA, Masrorpour F, Leyton CK, Yang L, Leuschner C, Puebla-Osorio N, Gandhi S, Nguyen QN, Cortez MA, Welsh JW. Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer. J Nanobiotechnology. 2022 Sep 19; 20(1):417. PMID: 36123677; PMCID: PMC9484155.
      Citations:    
    16. Barsoumian HB, Sezen D, Menon H, Younes AI, Hu Y, He K, Puebla-Osorio N, Wasley M, Hsu E, Patel RR, Yang L, Cortez MA, Welsh JW. High Plus Low Dose Radiation Strategy in Combination with TIGIT and PD1 Blockade to Promote Systemic Antitumor Responses. Cancers (Basel). 2022 Jan 03; 14(1). PMID: 35008385; PMCID: PMC8750272.
      Citations:    
    17. He K, Barsoumian HB, Bertolet G, Verma V, Leuschner C, Koay EJ, Ludmir EB, Hsu E, Pisipati E, Voss TA, Puebla-Osorio N, Cortez MA, Welsh JW. Novel Use of Low-Dose Radiotherapy to Modulate the Tumor Microenvironment of Liver Metastases. Front Immunol. 2021; 12:812210. PMID: 34975924; PMCID: PMC8714746.
      Citations:    Fields:    Translation:HumansAnimalsCells
    18. He K, Barsoumian HB, Sezen D, Puebla-Osorio N, Hsu EY, Verma V, Abana CO, Chen D, Patel RR, Gu M, Cortez MA, Welsh JW. Pulsed Radiation Therapy to Improve Systemic Control of Metastatic Cancer. Front Oncol. 2021; 11:737425. PMID: 34497773; PMCID: PMC8419338.
      Citations:    
    19. Sezen D, Verma V, He K, Abana CO, Barsoumian H, Ning MS, Tang C, Hurmuz P, Puebla-Osorio N, Chen D, Tendler I, Comeaux N, Nguyen QN, Chang JY, Welsh JW. Considerations for Clinical Trials Testing Radiotherapy Combined With Immunotherapy for Metastatic Disease. Semin Radiat Oncol. 2021 07; 31(3):217-226. PMID: 34090648.
      Citations:    Fields:    Translation:Humans
    20. Mueller-Schoell A, Puebla-Osorio N, Michelet R, Green MR, Huisinga W, Strati P, Chasen B, Neelapu SS, Yee C, Kloft C, K?nkele A. Early Survival Prediction Framework in CD19-Specific CAR-T Cell Immunotherapy Using a Quantitative Systems Pharmacology Model. Cancers (Basel). 2021 Jun 03; 13(11). PMID: 34205020; PMCID: PMC8199881.
      Citations: 3     
    21. Younes AI, Barsoumian HB, Sezen D, Verma V, Patel R, Wasley M, Hu Y, Dunn JD, He K, Chen D, Menon H, Masrorpour F, Gu M, Yang L, Puebla-Osorio N, Cortez MA, Welsh JW. Addition of TLR9 agonist immunotherapy to radiation improves systemic antitumor activity. Transl Oncol. 2021 Feb; 14(2):100983. PMID: 33340886; PMCID: PMC7750418.
      Citations: 8     
    22. Deng Q, Han G, Puebla-Osorio N, Ma MCJ, Strati P, Chasen B, Dai E, Dang M, Jain N, Yang H, Wang Y, Zhang S, Wang R, Chen R, Showell J, Ghosh S, Patchva S, Zhang Q, Sun R, Hagemeister F, Fayad L, Samaniego F, Lee HC, Nastoupil LJ, Fowler N, Eric Davis R, Westin J, Neelapu SS, Wang L, Green MR. Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas. Nat Med. 2020 12; 26(12):1878-1887. PMID: 33020644; PMCID: PMC8446909.
      Citations: 69     Fields:    Translation:HumansCells
    23. Patel RR, Verma V, Barsoumian HB, Ning MS, Chun SG, Tang C, Chang JY, Lee PP, Gandhi S, Balter P, Dunn JD, Chen D, Puebla-Osorio N, Cortez MA, Welsh JW. Use of Multi-Site Radiation Therapy for Systemic Disease Control. Int J Radiat Oncol Biol Phys. 2021 02 01; 109(2):352-364. PMID: 32798606; PMCID: PMC10644952.
      Citations: 6     Fields:    Translation:HumansAnimals
    24. Puebla-Osorio N, Soria-Castro R, Schcolnik-Cabrera A, Rodr?guez-L?pez G, Campillo-Navarro M, Estrada-Parra S, Estrada-Garc?a I, Chac?n-Salinas R, Ch?vez-Blanco AD. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells. J Immunol Res. 2019; 2019:9678098. PMID: 31001564; PMCID: PMC6437734.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    25. Puebla-Osorio N, Ullrich SE, Campillo-Navarro M, Leyva-Paredes K, Donis-Maturano L, Rodr?guez-L?pez GM, Soria-Castro R, Garc?a-P?rez BE, Luna-Herrera J, Flores-Romo L, Sumano-L?pez H, P?rez-Tapia SM, Estrada-Parra S, Estrada-Garc?a I, Chac?n-Salinas R. Mycobacterium tuberculosis Catalase Inhibits the Formation of Mast Cell Extracellular Traps. Front Immunol. 2018; 9:1161. PMID: 29892297; PMCID: PMC5985745.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    26. Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2311-E2319. PMID: 29463696; PMCID: PMC5878002.
      Citations: 3     Fields:    Translation:AnimalsCells
    27. Damiani E, Puebla-Osorio N, Lege BM, Liu J, Neelapu SS, Ullrich SE. Platelet activating factor-induced expression of p21 is correlated with histone acetylation. Sci Rep. 2017 02 03; 7:41959. PMID: 28157211; PMCID: PMC5291204.
      Citations:    Fields:    Translation:HumansCells
    28. Puebla-Osorio N, Sarchio SNE, Ullrich SE, Byrne SN. Detection of Infiltrating Mast Cells Using a Modified Toluidine Blue Staining. Methods Mol Biol. 2017; 1627:213-222. PMID: 28836204.
      Citations: 10     Fields:    Translation:AnimalsCells
    29. Puebla-Osorio N, Gorbea E, Ullrich SE, Damiani E. Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. J Invest Dermatol. 2015 Dec; 135(12):3034-3040. PMID: 26316070; PMCID: PMC4648694.
      Citations: 7     Fields:    Translation:HumansCells
    30. Puebla-Osorio N, Damiani E, Bover L, Ullrich SE. Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. Cell Death Dis. 2015 May 07; 6:e1745. PMID: 25950475; PMCID: PMC4669695.
      Citations: 7     Fields:    Translation:HumansCells
    31. Sun M, Zhou C, Zeng H, Puebla-Osorio N, Damiani E, Chen J, Wang H, Li G, Yin F, Shan L, Zuo D, Liao Y, Wang Z, Zheng L, Hua Y, Cai Z. Hiporfin-mediated photodynamic therapy in preclinical treatment of osteosarcoma. Photochem Photobiol. 2015 May-Jun; 91(3):533-44. PMID: 25619546.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    32. Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Gilbert BE, Brink R, Ullrich SE, Sun SC. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med. 2014 Jan 13; 211(1):137-51. PMID: 24378539; PMCID: PMC3892978.
      Citations: 36     Fields:    Translation:AnimalsCells
    33. Puebla-Osorio N, Kim J, Ojeda S, Zhang H, Tavana O, Li S, Wang Y, Ma Q, Schluns KS, Zhu C. A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. Oncogene. 2014 May 22; 33(21):2748-57. PMID: 23752193; PMCID: PMC5761319.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    34. Tavana O, Puebla-Osorio N, Kim J, Sang M, Jang S, Zhu C. Ku70 functions in addition to nonhomologous end joining in pancreatic ?-cells: a connection to ?-catenin regulation. Diabetes. 2013 Jul; 62(7):2429-38. PMID: 23474484; PMCID: PMC3712041.
      Citations: 9     Fields:    Translation:AnimalsCells
    35. Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-?B activation through deubiquitination of TRAF3. Nature. 2013 Feb 21; 494(7437):371-4. PMID: 23334419; PMCID: PMC3578967.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    36. Puebla-Osorio N, Miyahara Y, Coimbatore S, Kazimi N, Ullrich SE, Zhu C, Lim?n-Flores AY. Induction of B-cell lymphoma by UVB radiation in p53 haploinsufficient mice. BMC Cancer. 2011 Jan 26; 11:36. PMID: 21269511; PMCID: PMC3041776.
      Citations: 3     Fields:    Translation:Animals
    37. Tavana O, Benjamin CL, Puebla-Osorio N, Sang M, Ullrich SE, Ananthaswamy HN, Zhu C. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence. Cell Cycle. 2010 Aug 15; 9(16):3328-36. PMID: 20703098; PMCID: PMC3041166.
      Citations: 31     Fields:    Translation:AnimalsCells
    38. Dujka ME, Puebla-Osorio N, Tavana O, Sang M, Zhu C. ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo. Oncogene. 2010 Feb 18; 29(7):957-65. PMID: 19915617.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    39. Tavana O, Puebla-Osorio N, Sang M, Zhu C. Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice. Diabetes. 2010 Jan; 59(1):135-42. PMID: 19833883; PMCID: PMC2797914.
      Citations: 28     Fields:    Translation:Animals
    40. Puebla-Osorio N, Zhu C. DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis. Immunol Res. 2008; 41(2):103-22. PMID: 18214391.
      Citations: 16     Fields:    Translation:AnimalsCells
    41. Van Nguyen T, Puebla-Osorio N, Pang H, Dujka ME, Zhu C. DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model. J Exp Med. 2007 Jun 11; 204(6):1453-61. PMID: 17535972; PMCID: PMC2118600.
      Citations: 34     Fields:    Translation:Animals
    42. Puebla-Osorio N, Lacey DB, Alt FW, Zhu C. Early embryonic lethality due to targeted inactivation of DNA ligase III. Mol Cell Biol. 2006 May; 26(10):3935-41. PMID: 16648486; PMCID: PMC1489003.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    43. Kingsley RA, Abi Ghanem D, Puebla-Osorio N, Keestra AM, Berghman L, B?umler AJ. Fibronectin binding to the Salmonella enterica serotype Typhimurium ShdA autotransporter protein is inhibited by a monoclonal antibody recognizing the A3 repeat. J Bacteriol. 2004 Aug; 186(15):4931-9. PMID: 15262930; PMCID: PMC451617.
      Citations: 23     Fields:    Translation:AnimalsCells
    44. Puebla-Osorio N, Ramos KS, Falahatpisheh MH, Smith R, Berghman LR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin elicits aryl hydrocarbon receptor-mediated apoptosis in the avian DT40 pre-B-cell line through activation of caspases 9 and 3. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Aug; 138(4):461-8. PMID: 15536054.
      Citations:    Fields:    Translation:AnimalsCells
    45. Puebla-Osorio N, Proudman JA, Compton AE, Clements KE, Decuypere E, Vandesande F, Berghman LR. FSH- and LH-cells originate as separate cell populations and at different embryonic stages in the chicken embryo. Gen Comp Endocrinol. 2002 Jul; 127(3):242-8. PMID: 12225765.
      Citations: 1     Fields:    Translation:Animals
    46. Immunocytochemical evidence for the existence of a lamprey luteinizing hormone-releasing hormone type III-like peptide in the chicken hypothalamus. British Poultry Science. 41.
    47. Platelet-activating factor induces epigenetic modifications in human mast cells. Journal of Investigative Dermatology. 135:3034-3040.
    48. Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. Cell Death and Disease. 6.
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