SRINIVASCHAMAKURISRINIVAS CHAMAKURI8410CHAMAKURI, SRINIVASAssistant Professorprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonOne Baylor PlazaHouston, 77030TX0.9904640.0055250572research areas7.284450.05008425coauthor of21.15161.5339960similar to1122selected publicationsLeukemiaMolecular & Cellular OncologyMD AndersonJORGE ECORTESJORGE E CORTES8637CORTES, JORGE EProfessorHAGOP MKANTARJIANHAGOP M KANTARJIAN8501KANTARJIAN, HAGOP MProfessorAuthorship 234705224673632Aeluri M, Chamakuri S, Dasari B, Guduru SK, Jimmidi R, Jogula S, Arya PChemical reviewsSmall molecule modulators of protein-protein interactions: selected case studies. Chem Rev. 2014 May 14; 114(9):4640-94.Chem Rev2014-03-27T00:00:002014Small molecule modulators of protein-protein interactions: selected case studies.Authorship 275582224900727Reddy Guduru SK, Chamakuri S, Chandrasekar G, Kitambi SS, Arya PACS medicinal chemistry lettersTetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay. ACS Med Chem Lett. 2013 Jul 11; 4(7):666-70.ACS Med Chem Lett2013-05-24T00:00:002013Tetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay.KEVINMACKENZIEKEVIN MACKENZIE11004MACKENZIE, KEVINAssociate ProfessorAuthorship 295668126167941Chamakuri S, Jogula S, Arya PACS combinatorial scienceRegio- and Stereocontrolled Dieckmann Approach to Treprostinil-Inspired, Polycyclic Scaffold For Building Macrocyclic Diversity. ACS Comb Sci. 2015 Aug 10; 17(8):437-41.ACS Comb Sci2015-07-16T00:00:002015Regio- and Stereocontrolled Dieckmann Approach to Treprostinil-Inspired, Polycyclic Scaffold For Building Macrocyclic Diversity.74Professor10Assistant Professor21Chair14Associate ProfessorJOHNTAINERJOHN TAINER11926TAINER, JOHNProfessorAuthorship 869435428441579Jogula S, Soorneedi AR, Gaddam J, Chamakuri S, Deora GS, Indarapu RK, Ramgopal MK, Dravida S, Arya PEuropean journal of medicinal chemistryGeldanamycin-inspired compounds induce direct trans-differentiation of human mesenchymal stem cells to neurons. Eur J Med Chem. 2017 Jul 28; 135:110-116.Eur J Med Chem2017-04-18T00:00:002017Geldanamycin-inspired compounds induce direct trans-differentiation of human mesenchymal stem cells to neurons.D010879Chemicals & Drugs51420980.514239PiperazinesD015195Occupations2303640.819917Drug DesignD011480Chemicals & Drugs1452120.87422Protease InhibitorsD003959Chemicals & Drugs23250.975894DiaminesD054852Chemicals & Drugs1081690.853061Small Molecule LibrariesAuthorship 9168922Authorship 929692129751727Chamakuri S, Jain P, Reddy Guduru SK, Arney JW, MacKenzie KR, Santini C, Young DWThe Journal of organic chemistrySynthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 06 15; 83(12):6541-6555.J Org Chem2018-06-06T00:00:002018Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.30180575Reddy Guduru SK, Chamakuri S, Raji IO, MacKenzie KR, Santini C, Young DWThe Journal of organic chemistrySynthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 10 05; 83(19):11777-11793.J Org Chem2018-09-18T00:00:002018Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production.Department of Pathology & ImmunologyPathologyBaylor College of MedicineMARTINMATZUKMARTIN MATZUK0.000000000000000.000000000000001976MATZUK, MARTINProfessorAuthorship 9409821Authorship 941368330848904Jain P, Raji IO, Chamakuri S, MacKenzie KR, Ebright BT, Santini C, Young DWThe Journal of organic chemistrySynthesis of Enantiomerically Pure 5-Substituted Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 05 17; 84(10):6040-6064.J Org Chem2019-04-29T00:00:002019Synthesis of Enantiomerically Pure 5-Substituted Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.30855144Chamakuri S, Jain P, Guduru SRK, Arney JW, MacKenzie KR, Santini C, Young DWThe Journal of organic chemistryCorrection to Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 Apr 05; 84(7):4575.J Org Chem2019-03-11T00:00:002019Correction to Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.TIMOTHYPALZKILLTIMOTHY PALZKILL0.000000000000000.000000000000003364PALZKILL, TIMOTHYChair71Postdoc Fellows and AssociatesPostDocAuthorship 10030703Authorship 1003710133074645Monty OBC, Simmons N, Chamakuri S, Matzuk MM, Young DWACS combinatorial scienceSolution-Phase Fmoc-Based Peptide Synthesis for DNA-Encoded Chemical Libraries: Reaction Conditions, Protecting Group Strategies, and Pitfalls. ACS Comb Sci. 2020 12 14; 22(12):833-843.ACS Comb Sci2020-10-19T00:00:002020Solution-Phase Fmoc-Based Peptide Synthesis for DNA-Encoded Chemical Libraries: Reaction Conditions, Protecting Group Strategies, and Pitfalls.33118584Chamakuri S, Shah MM, Yang DCH, Santini C, Young DWOrganic & biomolecular chemistryPractical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines. Org Biomol Chem. 2020 11 12; 18(43):8844-8849.Org Biomol Chem2020-11-12T00:00:002020Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines.Authorship 10088981733450205Bowling EA, Wang JH, Gong F, Wu W, Neill NJ, Kim IS, Tyagi S, Orellana M, Kurley SJ, Dominguez-Vida?a R, Chung HC, Hsu TY, Dubrulle J, Saltzman AB, Li H, Meena JK, Canlas GM, Chamakuri S, Singh S, Simon LM, Olson CM, Dobrolecki LE, Lewis MT, Zhang B, Golding I, Rosen JM, Young DW, Malovannaya A, Stossi F, Miles G, Ellis MJ, Yu L, Buonamici S, Lin CY, Karlin KL, Zhang XH, Westbrook TFCellSpliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer. Cell. 2021 01 21; 184(2):384-403.e21.Cell2021-01-14T00:00:002021Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer.Authorship 1028263134426525Chamakuri S, Lu S, Ucisik MN, Bohren KM, Chen YC, Du HC, Faver JC, Jimmidi R, Li F, Li JY, Nyshadham P, Palmer SS, Pollet J, Qin X, Ronca SE, Sankaran B, Sharma KL, Tan Z, Versteeg L, Yu Z, Matzuk MM, Palzkill T, Young DWProceedings of the National Academy of Sciences of the United States of AmericaDNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).Proc Natl Acad Sci U S A2021-09-07T00:00:002021DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors.Authorship 1030632134571488Chamakuri S, Chung MK, Samuel ELG, Tran KA, Chen YC, Nyshadham P, Santini C, Matzuk MM, Young DWBioorganic & medicinal chemistryDesign and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library. Bioorg Med Chem. 2021 10 15; 48:116387.Bioorg Med Chem2021-09-13T00:00:002021Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library.true1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesAmolVivekiAmol Basagonda Viveki17223Viveki, AmolPostdoc Fellows and AssociatesAuthorship 10388761235333654Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Jim?nez-Panizo A, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Est?banez-Perpi?? E, Venken K, Moore DD, Young DW, Maletic-Savatic MProceedings of the National Academy of Sciences of the United States of AmericaOleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2023784119.Proc Natl Acad Sci U S A2022-03-25T00:00:002022Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.Authorship 1044487735471084Moghadasi SA, Esler MA, Otsuka Y, Becker JT, Moraes SN, Anderson CB, Chamakuri S, Belica C, Wick C, Harki DA, Young DW, Scampavia L, Spicer TP, Shi K, Aihara H, Brown WL, Harris RSmBioGain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 Mpro/3CLpro in Living Cells. mBio. 2022 06 28; 13(3):e0078422.mBio2022-04-26T00:00:002022Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 Mpro/3CLpro in Living Cells.true1Assistant ProfessorAssistant ProfessorAuthorship 10473731Authorship 1047712235668207Young DW, Chamakuri SNature chemistryTrisubstituted triumph. Nat Chem. 2022 Jun; 14(6):595-597.Nat Chem2022-06-01T00:00:002022Trisubstituted triumph.35684357Chamakuri S, Tang SA, Tran KA, Guduru SKR, Bolin PK, MacKenzie KR, Young DWMolecules (Basel, Switzerland)A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines. Molecules. 2022 May 25; 27(11).Molecules2022-05-25T00:00:002022A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines.Authorship 1075056737462979Viveki AB, Mansfield TM, Tran KA, Lenkeit E, MacKenzie KR, Young DW, Chamakuri SChemistry (Weinheim an der Bergstrasse, Germany)Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles. Chemistry. 2023 Oct 02; 29(55):e202301888.Chemistry2023-08-29T00:00:002023Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles.37542196Jimmidi R, Chamakuri S, Lu S, Ucisik MN, Chen PJ, Bohren KM, Moghadasi SA, Versteeg L, Nnabuife C, Li JY, Qin X, Chen YC, Faver JC, Nyshadham P, Sharma KL, Sankaran B, Judge A, Yu Z, Li F, Pollet J, Harris RS, Matzuk MM, Palzkill T, Young DWCommunications chemistryDNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem. 2023 Aug 04; 6(1):164.Commun Chem2023-08-04T00:00:002023DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors.true1Associate ProfessorAssociate Professortrue1ChairChairtrue1ProfessorProfessorDepartment of Biochemistry and Molecular PharmacologyBiochemistry & Mol PharmacologyAuthorship 10794132true1Associate ProfessorAssociate ProfessorAuthorship 1085591338117688Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, Wang J, Tan Z, Judge A, Hu L, Sankaran B, Li F, Prasad BVV, Matzuk MM, Palzkill TJournal of medicinal chemistryExploiting the Carboxylate-Binding Pocket of ?-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J Med Chem. 2024 Jan 11; 67(1):620-642.J Med Chem2023-12-20T00:00:002023Exploiting the Carboxylate-Binding Pocket of ?-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library.Authorship 10872981238229743Holmes S, Jain P, Rodriguez KG, Williams J, Yu Z, Cerda-Smith C, Samuel ELG, Campbell J, Hakenjos JM, Monsivais D, Li F, Chamakuri S, Matzuk MM, Santini C, MacKenzie KR, Young DWACS medicinal chemistry lettersChemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1. ACS Med Chem Lett. 2024 Jan 11; 15(1):107-115.ACS Med Chem Lett2024-01-02T00:00:002024Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1.Authorship 10909771038506470Tang SA, Fults A, Boyd SR, Gattu N, Tran KA, Fan J, MacKenzie KR, Palzkill T, Young DW, Chamakuri SOrganic lettersExpanding Complex Morpholines Using Systematic Chemical Diversity. Org Lett. 2024 Mar 20.Org Lett2024-03-20T00:00:002024Expanding Complex Morpholines Using Systematic Chemical Diversity.true1ProfessorProfessortrue1ProfessorProfessortrue1ProfessorProfessorDAMIANYOUNGDAMIAN YOUNG7119YOUNG, DAMIANAssociate Professor