MELANIESAMUELMELANIE SAMUEL8206SAMUEL, MELANIEAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonOne Baylor PlazaHouston, 77030TX2.619550.00652948238research areas0.9417940.04118388coauthor of50.11926.1781660similar to1141selected publicationsAuthorship 1577481Authorship 15775411Authorship 1577602Authorship 1577622Authorship 1577651Authorship 1577716Authorship 1577772Authorship 1577973Authorship 1578036Authorship 1578242Authorship 1578291Authorship 15783110Authorship 1578381Authorship 1578433Authorship 1578511Authorship 1578562Authorship 1578622Authorship 1578842Authorship 1578904Authorship 1579235Authorship 1579982Authorship 1580501Authorship 1580931Authorship 158131116352536Shrestha B, Samuel MA, Diamond MSJournal of virologyCD8+ T cells require perforin to clear West Nile virus from infected neurons. J Virol. 2006 Jan; 80(1):119-29.J Virol2006-01-01T00:00:002006CD8+ T cells require perforin to clear West Nile virus from infected neurons.16361237Pepin KM, Samuel MA, Wichman HAGeneticsVariable pleiotropic effects from mutations at the same locus hamper prediction of fitness from a fitness component. Genetics. 2006 Apr; 172(4):2047-56.Genetics2005-12-15T00:00:002005Variable pleiotropic effects from mutations at the same locus hamper prediction of fitness from a fitness component.23056392Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JRPloS oneAgrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One. 2012; 7(10):e46663.PLoS One2012-10-03T00:00:002012Agrin and synaptic laminin are required to maintain adult neuromuscular junctions.16455125Rosenke K, Samuel MA, McDowell ET, Toerne MA, Fortunato EAVirologyAn intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection. Virology. 2006 Apr 25; 348(1):19-34.Virology2006-02-07T00:00:002006An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection.18562536Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M, Diamond MSJournal of virologyInterferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol. 2008 Sep; 82(17):8465-75.J Virol2008-06-18T00:00:002008Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection.19587044Szretter KJ, Samuel MA, Gilfillan S, Fuchs A, Colonna M, Diamond MSJournal of virologyThe immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol. 2009 Sep; 83(18):9329-38.J Virol2009-07-08T00:00:002009The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis.25086610Samuel MA, Voinescu PE, Lilley BN, de Cabo R, Foretz M, Viollet B, Pawlyk B, Sandberg MA, Vavvas DG, Sanes JRNature neuroscienceLKB1 and AMPK regulate synaptic remodeling in old age. Nat Neurosci. 2014 Sep; 17(9):1190-7.Nat Neurosci2014-08-03T00:00:002014LKB1 and AMPK regulate synaptic remodeling in old age.23269784Hussmann KL, Samuel MA, Kim KS, Diamond MS, Fredericksen BLJournal of virologyDifferential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes. J Virol. 2013 Mar; 87(5):2814-22.J Virol2012-12-26T00:00:002012Differential replication of pathogenic and nonpathogenic strains of West Nile virus within astrocytes.15749120Pierson TC, Diamond MS, Ahmed AA, Valentine LE, Davis CW, Samuel MA, Hanna SL, Puffer BA, Doms RWVirologyAn infectious West Nile virus that expresses a GFP reporter gene. Virology. 2005 Mar 30; 334(1):28-40.Virology2005-03-30T00:00:002005An infectious West Nile virus that expresses a GFP reporter gene.16699014Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, Diamond MSJournal of virologyGamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol. 2006 Jun; 80(11):5338-48.J Virol2006-06-01T00:00:002006Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection.18715906Daffis S, Samuel MA, Suthar MS, Gale M, Diamond MSJournal of virologyToll-like receptor 3 has a protective role against West Nile virus infection. J Virol. 2008 Nov; 82(21):10349-58.J Virol2008-08-20T00:00:002008Toll-like receptor 3 has a protective role against West Nile virus infection.17676997Daffis S, Samuel MA, Keller BC, Gale M, Diamond MSPLoS pathogensCell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms. PLoS Pathog. 2007 Jul 27; 3(7):e106.PLoS Pathog2007-07-27T00:00:002007Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.17715228Noueiry AO, Olivo PD, Slomczynska U, Zhou Y, Buscher B, Geiss B, Engle M, Roth RM, Chung KM, Samuel M, Diamond MSJournal of virologyIdentification of novel small-molecule inhibitors of West Nile virus infection. J Virol. 2007 Nov; 81(21):11992-2004.J Virol2007-08-22T00:00:002007Identification of novel small-molecule inhibitors of West Nile virus infection.16809306Samuel MA, Whitby K, Keller BC, Marri A, Barchet W, Williams BR, Silverman RH, Gale M, Diamond MSJournal of virologyPKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol. 2006 Jul; 80(14):7009-19.J Virol2006-07-01T00:00:002006PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.17939996Samuel MA, Wang H, Siddharthan V, Morrey JD, Diamond MSProceedings of the National Academy of Sciences of the United States of AmericaAxonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17140-5.Proc Natl Acad Sci U S A2007-10-15T00:00:002007Axonal transport mediates West Nile virus entry into the central nervous system and induces acute flaccid paralysis.16973541Samuel MA, Diamond MSJournal of virologyPathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. J Virol. 2006 Oct; 80(19):9349-60.J Virol2006-10-01T00:00:002006Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion.16973548Keller BC, Fredericksen BL, Samuel MA, Mock RE, Mason PW, Diamond MS, Gale MJournal of virologyResistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence. J Virol. 2006 Oct; 80(19):9424-34.J Virol2006-10-01T00:00:002006Resistance to alpha/beta interferon is a determinant of West Nile virus replication fitness and virulence.16103196Klein RS, Lin E, Zhang B, Luster AD, Tollett J, Samuel MA, Engle M, Diamond MSJournal of virologyNeuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. J Virol. 2005 Sep; 79(17):11457-66.J Virol2005-09-01T00:00:002005Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis.20169186Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, Babrzadeh F, Gharizadeh B, Grimm D, Kay M, Koike S, Sarnow P, Ronaghi M, Ding SW, Harris E, Chow M, Diamond MS, Kirkegaard K, Glenn JS, Fire AZPLoS pathogensSix RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010 Feb 12; 6(2):e1000764.PLoS Pathog2010-02-12T00:00:002010Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems.22049445Samuel MA, Zhang Y, Meister M, Sanes JRThe Journal of neuroscience : the official journal of the Society for NeuroscienceAge-related alterations in neurons of the mouse retina. J Neurosci. 2011 Nov 02; 31(44):16033-44.J Neurosci2011-11-02T00:00:002011Age-related alterations in neurons of the mouse retina.16227257Samuel MA, Diamond MSJournal of virologyAlpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol. 2005 Nov; 79(21):13350-61.J Virol2005-11-01T00:00:002005Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival.16229682Shiryaev SA, Ratnikov BI, Chekanov AV, Sikora S, Rozanov DV, Godzik A, Wang J, Smith JW, Huang Z, Lindberg I, Samuel MA, Diamond MS, Strongin AYThe Biochemical journalCleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J. 2006 Jan 15; 393(Pt 2):503-11.Biochem J2006-01-15T00:00:002006Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.19273254Diamond MS, Mehlhop E, Oliphant T, Samuel MAFrontiers in bioscience (Landmark edition)The host immunologic response to West Nile encephalitis virus. Front Biosci (Landmark Ed). 2009 01 01; 14(8):3024-34.Front Biosci (Landmark Ed)2009-01-01T00:00:002009The host immunologic response to West Nile encephalitis virus.17192305Samuel MA, Morrey JD, Diamond MSJournal of virologyCaspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis. J Virol. 2007 Mar; 81(6):2614-23.J Virol2006-12-27T00:00:002006Caspase 3-dependent cell death of neurons contributes to the pathogenesis of West Nile virus encephalitis.Anesthesiology & PeriOperative MedicineMD AndersonHUI-LINPANHUI-LIN PAN9317PAN, HUI-LINProfessor74Professor10Assistant Professor14Associate Professor47Distinguished Service ProfessorSHANNONRONCASHANNON RONCA12097RONCA, SHANNONAssistant Professor53Graduate StudentAuthorship 884070829576390Sarin S, Zuniga-Sanchez E, Kurmangaliyev YZ, Cousins H, Patel M, Hernandez J, Zhang KX, Samuel MA, Morey M, Sanes JR, Zipursky SLNeuronRole for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In?Vivo Somatic CRISPR Mutagenesis. Neuron. 2018 04 04; 98(1):109-126.e8.Neuron2018-03-22T00:00:002018Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In?Vivo Somatic CRISPR Mutagenesis.true1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service Professortrue1ProfessorProfessorD009474Anatomy61422850.451917NeuronsD013569Anatomy1765130.718689SynapsesD012160Anatomy1735320.740835RetinaD014902Living Beings421260.865076West Nile virusAuthorship 9337042130157441Albrecht NE, Alevy J, Jiang D, Burger CA, Liu BI, Li F, Wang J, Kim SY, Hsu CW, Kalaga S, Udensi U, Asomugha C, Bohat R, Gaspero A, Justice MJ, Westenskow PD, Yamamoto S, Seavitt JR, Beaudet AL, Dickinson ME, Samuel MACell reportsRapid and Integrative Discovery of Retina Regulatory Molecules. Cell Rep. 2018 08 28; 24(9):2506-2519.Cell Rep2018-08-28T00:00:002018Rapid and Integrative Discovery of Retina Regulatory Molecules.D014901Disorders611490.831869West Nile Fever2021-09-29NIHSAMUEL, MELANIE A2016-09-30Synaptic Reprogramming of Adult NeuronsDP2EY0279842019-01-31NIHSAMUEL, MELANIE A2015-04-01Molecular Mechanisms of Age-related Synaptic DisorganizationR00AG0444442015-05-31NIHSAMUEL, MELANIE A2013-09-01Molecular Mechanisms of Age-related Synaptic DisorganizationK99AG044444Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorNeuroscienceDepartment of NeurologyDepartment of NeuroscienceDepartment of OphthalmologyDepartment of PediatricsDepartment of Pathology & ImmunologyHuffington Center on AgingPediatrics-Tropical MedicineHuffington Ctr on AgingNeurologyNeuroscienceOphthalmologyPathologyPediatrics-NeurologyBaylor College of MedicineKRISTYMURRAYKRISTY MURRAY29.70508570000000-95.401808700000004096MURRAY, KRISTYProfessorSAMUELWUSAMUEL WU29.70508570000000-95.401808700000002966WU, SAMUELProfessorHUDAZOGHBIHUDA ZOGHBI29.71010310000000-95.397396100000002830ZOGHBI, HUDADistinguished Service ProfessorROYSILLITOEROY SILLITOE29.71073630000000-95.396604500000004100SILLITOE, ROYProfessorJEFFREYNOEBELSJEFFREY NOEBELS0.000000000000000.000000000000003151NOEBELS, JEFFREYProfessorAuthorship 948816531175897Alevy J, Burger CA, Albrecht NE, Jiang D, Samuel MANeurochemistry internationalProgressive myoclonic epilepsy-associated gene Kctd7 regulates retinal neurovascular patterning and function. Neurochem Int. 2019 10; 129:104486.Neurochem Int2019-06-06T00:00:002019Progressive myoclonic epilepsy-associated gene Kctd7 regulates retinal neurovascular patterning and function.2021-07-31NIHSAMUEL, MELANIE A2019-08-15Synaptic decline in retina as a predictor of Alzheimer's diseaseR56AG061808Principal Investigator2024-06-30NIHSAMUEL, MELANIE A2019-09-01Molecular Basis of Outer Retina Development and RepairR01EY030458Principal InvestigatorAuthorship 956074231557459Greer PL, Samuel MANeuronBecoming a Principal Investigator: Designing and Navigating Your Academic Adventure. Neuron. 2019 09 25; 103(6):959-963.Neuron2019-09-25T00:00:002019Becoming a Principal Investigator: Designing and Navigating Your Academic Adventure.Authorship 957185631609468Jiang D, Burger CA, Casasent AK, Albrecht NE, Li F, Samuel MAThe Journal of comparative neurologySpatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. J Comp Neurol. 2020 04 01; 528(5):729-755.J Comp Neurol2019-10-31T00:00:002019Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.Authorship 975039331888774Li F, Jiang D, Samuel MANeural developmentMicroglia in the developing retina. Neural Dev. 2019 12 30; 14(1):12.Neural Dev2019-12-30T00:00:002019Microglia in the developing retina.71Postdoc Fellows and AssociatesPostDocAuthorship 988842932378514Burger CA, Alevy J, Casasent AK, Jiang D, Albrecht NE, Liang JH, Hirano AA, Brecha NC, Samuel MAeLifeLKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina. Elife. 2020 05 07; 9.Elife2020-05-07T00:00:002020LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina.true1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesRobertMackinRobert Daniel Mackin16168Mackin, RobertPostdoc Fellows and AssociatesAuthorship 1004905433177995Burger CA, Jiang D, Li F, Samuel MAFrontiers in neural circuitsC1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina. Front Neural Circuits. 2020; 14:583391.Front Neural Circuits2020-10-16T00:00:002020C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina.Authorship 1010523533535040Burger CA, Albrecht NE, Jiang D, Liang JH, Poch? RA, Samuel MACell reportsLKB1 and AMPK instruct cone nuclear position to modify visual function. Cell Rep. 2021 02 02; 34(5):108698.Cell Rep2021-02-02T00:00:002021LKB1 and AMPK instruct cone nuclear position to modify visual function.33848537Burger CA, Jiang D, Mackin RD, Samuel MADevelopmental biologyDevelopment and maintenance of vision's first synapse. Dev Biol. 2021 08; 476:218-239.Dev Biol2021-04-10T00:00:002021Development and maintenance of vision's first synapse.Authorship 10164704true1Graduate StudentGraduate StudentJeffreyZhuJeffrey Zhu16690Zhu, JeffreyGraduate Studenttrue1Assistant ProfessorAssistant ProfessorAuthorship 1033809834743323D'Souza SP, Swygart DI, Wienbar SR, Upton BA, Zhang KX, Mackin RD, Casasent AK, Samuel MA, Schwartz GW, Lang RAThe Journal of comparative neurologyRetinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells. J Comp Neurol. 2022 06; 530(8):1247-1262.J Comp Neurol2021-12-15T00:00:002021Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.true1Associate ProfessorAssociate Professor2Associate ProfessorAssociate Professor3Associate ProfessorAssociate Professortrue1ProfessorProfessorAuthorship 1051433735880013Albrecht NE, Jiang D, Akhanov V, Hobson R, Speer CM, Robichaux MA, Samuel MACell reports methodsRapid 3D-STORM imaging of diverse molecular targets in tissue. Cell Rep Methods. 2022 07 18; 2(7):100253.Cell Rep Methods2022-07-11T00:00:002022Rapid 3D-STORM imaging of diverse molecular targets in tissue.true1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesMohamedTawfikMohamed Tawfik18131Tawfik, MohamedPostdoc Fellows and Associatestrue1ProfessorProfessorAuthorship 10551624Authorship 10591499Authorship 10575861036179691Cao Y, Fajardo D, Guerrero-Given D, Samuel MA, Ohtsuka T, Boye SE, Kamasawa N, Martemyanov KACurrent biology : CBPost-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Curr Biol. 2022 11 21; 32(22):4783-4796.e3.Curr Biol2022-09-29T00:00:002022Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.36379210Jiang D, Burger CA, Akhanov V, Liang JH, Mackin RD, Albrecht NE, Andrade P, Schafer DP, Samuel MAImmunityNeuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina. Immunity. 2022 12 13; 55(12):2318-2335.e7.Immunity2022-11-14T00:00:002022Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.35972048Liang JH, Alevy J, Akhanov V, Seo R, Massey CA, Jiang D, Zhou J, Sillitoe RV, Noebels JL, Samuel MADisease models & mechanismsKctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects. Dis Model Mech. 2022 09 01; 15(9).Dis Model Mech2022-09-01T00:00:002022Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects.Authorship 1069864437196423Zhu JD, Tarachand SP, Abdulwahab Q, Samuel MAAnnual review of vision scienceStructure, Function, and Molecular Landscapes of the Aging Retina. Annu Rev Vis Sci. 2023 09 15; 9:177-199.Annu Rev Vis Sci2023-05-17T00:00:002023Structure, Function, and Molecular Landscapes of the Aging Retina.https://www.bcm.edu/departments/pediatrics/divisions-and-centers/tropical-medicine/research/researchLaboratory of Translational Virologyhttps://www.bcm.edu/departments/pediatrics/divisions-and-centers/tropical-medicine/research/researchFeigin Biosafety Level 3 FacilityAuthorship 1079188837572663Liang JH, Akhanov V, Ho A, Tawfik M, D'Souza SP, Cameron MA, Lang RA, Samuel MACurrent biology : CBDopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina. Curr Biol. 2023 09 25; 33(18):3821-3834.e5.Curr Biol2023-08-11T00:00:002023Dopamine signaling from ganglion cells directs layer-specific angiogenesis in the retina.2027-01-31NIHSAMUEL, MELANIE A2023-09-01Microglial plasticity mechanisms in the developing retinaR01EY035254Principal Investigatortrue1ProfessorProfessor