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SCOTT R. GILBERTSON

TitleJoint Faculty
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological and Pharmaceutical Sciences
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    F32GM011845     (GILBERTSON, SCOTT R)May 31, 1988
    NIH/NIGMS
    STUDY OF STRIGA GERMINATION FACTOR &ITS ANALOGS
    Role: Principal Investigator

    R01GM056490     (GILBERTSON, SCOTT R)Aug 1, 1997 - Jul 31, 2004
    NIH/NIGMS
    COMBINATORIAL SYNTHESIS OF PHOSPHINE LIGANDS
    Role: Principal Investigator

    P41GM079588     (GILBERTSON, SCOTT R)Sep 15, 2006 - Aug 31, 2009
    NIH/NIGMS
    Synthesis of Pilot Libraries Based on Medicinal Relevant Scaffolds
    Role: Principal Investigator

    P41GM089173     (GILBERTSON, SCOTT R)Jun 1, 2010 - May 31, 2014
    NIH/NIGMS
    Pilot Scale Libraries Based on Biologically Active Scaffolds
    Role: Principal Investigator

    R01DA030977     (CUNNINGHAM, KATHRYN A.)Sep 30, 2010 - Aug 31, 2015
    NIH/NIDA
    Inhibitors of 5-HT2CR Protein:Protein Interactions for Stimulant Pharmacotherapy
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Abbasgholizadeh R, Zhang H, Craft JW, Bryan RM, Bark SJ, Briggs JM, Fox RO, Agarkov A, Zimmer WE, Gilbertson SR, Schwartz RJ. Feature article: Discovery of vascular Rho kinase (ROCK) inhibitory peptides. Exp Biol Med (Maywood). 2019 Aug; 244(11):940-951. PMID: 31132884.
      View in: PubMed
    2. Tao Y, Gilbertson SR. Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis. Chem Commun (Camb). 2018 Oct 04; 54(80):11292-11295. PMID: 30232479.
      View in: PubMed
    3. Felsing DE, Anastasio NC, Miszkiel JM, Gilbertson SR, Allen JA, Cunningham KA. Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. PLoS One. 2018; 13(8):e0203137. PMID: 30157263.
      View in: PubMed
    4. Li F, Zhang N, Gorantla S, Gilbertson SR, Pati D. The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes. Front Pharmacol. 2018; 9:313. PMID: 29867452.
      View in: PubMed
    5. Gilbertson SR, Chen YC, Soto CA, Yang Y, Rice KC, Cunningham KA, Anastasio NC. Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907. Bioorg Med Chem Lett. 2018 05 01; 28(8):1381-1385. PMID: 29555153.
      View in: PubMed
    6. Soto CA, Shashack MJ, Fox RG, Bubar MJ, Rice KC, Watson CS, Cunningham KA, Gilbertson SR, Anastasio NC. Novel Bivalent 5-HT2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo. ACS Chem Neurosci. 2018 03 21; 9(3):514-521. PMID: 29111677.
      View in: PubMed
    7. Chen YC, Hartley RM, Anastasio NC, Cunningham KA, Gilbertson SR. Synthesis and Structure-Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist. ACS Chem Neurosci. 2017 05 17; 8(5):1004-1010. PMID: 28414422.
      View in: PubMed
    8. Do HT, Zhang N, Pati D, Gilbertson SR. Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. Bioorg Med Chem Lett. 2016 09 15; 26(18):4446-4450. PMID: 27530289.
      View in: PubMed
    9. Do H, Kang CW, Cho JH, Gilbertson SR. Enantioselective Synthesis of (-)-Dysiherbaine. Org Lett. 2015 Aug 21; 17(16):3972-4. PMID: 26258884.
      View in: PubMed
    10. Canlas GM, Gilbertson SR. [4+2+2] Cycloaddition catalyzed by a new cationic rhodium-bisphosphine monooxide complex. Chem Commun (Camb). 2014 May 21; 50(39):5007-10. PMID: 24706156.
      View in: PubMed
    11. Zhao Y, Gilbertson SR. Synthesis of proline-based N-heterocyclic carbene ligands. Org Lett. 2014 Feb 21; 16(4):1033-5. PMID: 24495075.
      View in: PubMed
    12. De S, Chen L, Zhang S, Gilbertson SR. Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones. ACS Comb Sci. 2013 Jul 08; 15(7):340-3. PMID: 23742807.
      View in: PubMed
    13. Anastasio NC, Gilbertson SR, Bubar MJ, Agarkov A, Stutz SJ, Jeng Y, Bremer NM, Smith TD, Fox RG, Swinford SE, Seitz PK, Charendoff MN, Craft JW, Laezza FM, Watson CS, Briggs JM, Cunningham KA. Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior. J Neurosci. 2013 Jan 23; 33(4):1615-30. PMID: 23345234.
      View in: PubMed
    14. Gilbertson SR. Chemistry. Relay reactions that trap organometallic intermediates. Science. 2012 Dec 14; 338(6113):1432-3. PMID: 23239726.
      View in: PubMed
    15. Schein CH, Chen D, Ma L, Kanalas JJ, Gao J, Jimenez ME, Sower LE, Walter MA, Gilbertson SR, Peterson JW. Pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor. Toxins (Basel). 2012 Nov 08; 4(11):1288-300. PMID: 23202316.
      View in: PubMed
    16. Cunningham KA, Anastasio NC, Fox RG, Stutz SJ, Bubar MJ, Swinford SE, Watson CS, Gilbertson SR, Rice KC, Rosenzweig-Lipson S, Moeller FG. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. ACS Chem Neurosci. 2013 Jan 16; 4(1):110-21. PMID: 23336050.
      View in: PubMed
    17. Chen D, Ma L, Kanalas JJ, Gao J, Pawlik J, Jimenez ME, Walter MA, Peterson JW, Gilbertson SR, Schein CH. Structure-based redesign of an edema toxin inhibitor. Bioorg Med Chem. 2012 Jan 01; 20(1):368-76. PMID: 22154558.
      View in: PubMed
    18. Shashack MJ, Cunningham KA, Seitz PK, McGinnis A, Smith T, Watson CS, Gilbertson SR. Synthesis and evaluation of dimeric derivatives of 5-HT(2A) receptor (5-HT(2A)R) antagonist M-100907. ACS Chem Neurosci. 2011 Nov 16; 2(11):640-644. PMID: 22247793.
      View in: PubMed
    19. Khalaf J, Estrella-Jimenez ME, Shashack MJ, Phatak SS, Zhang S, Gilbertson SR. Design, synthesis, and diversification of 3,5-substituted enone library. ACS Comb Sci. 2011 Jul 11; 13(4):351-6. PMID: 21648460.
      View in: PubMed
    20. Cunningham KA, Fox RG, Anastasio NC, Bubar MJ, Stutz SJ, Moeller FG, Gilbertson SR, Rosenzweig-Lipson S. Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues. Neuropharmacology. 2011 Sep; 61(3):513-23. PMID: 21575646.
      View in: PubMed
    21. Prasad BA, Buechele AE, Gilbertson SR. Pd-NHC catalyzed cyclopentannulation of diazabicyclic alkenes with ortho-aryl halides. Org Lett. 2010 Dec 03; 12(23):5422-5. PMID: 21043477.
      View in: PubMed
    22. Tanifum EA, Gilbertson SR. Design, synthesis, and diversification of 5,5-dimethyl cyclohexen-1,4-dione library. J Comb Chem. 2010 May 10; 12(3):318-20. PMID: 20387791.
      View in: PubMed
    23. Moen ST, Blumentritt CA, Slater TM, Patel SD, Tutt CB, Estrella-Jimenez ME, Pawlik J, Sower L, Popov VL, Schein CH, Gilbertson SR, Peterson JW, Torres AG. Testing the efficacy and toxicity of adenylyl cyclase inhibitors against enteric pathogens using in vitro and in vivo models of infection. Infect Immun. 2010 Apr; 78(4):1740-9. PMID: 20123712.
      View in: PubMed
    24. Prasad BA, Gilbertson SR. One-pot synthesis of unsymmetrical N-heterocyclic carbene ligands from N-(2-iodoethyl)arylamine salts. Org Lett. 2009 Aug 20; 11(16):3710-3. PMID: 19624103.
      View in: PubMed
    25. Tanifum EA, Kots AY, Choi BK, Murad F, Gilbertson SR. Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis. Bioorg Med Chem Lett. 2009 Jun 01; 19(11):3067-71. PMID: 19409779.
      View in: PubMed
    26. Ji Z, Mei FC, Lory PL, Gilbertson SR, Chen Y, Cheng X. Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer. Front Biosci (Landmark Ed). 2009 Jan 01; 14:2904-10. PMID: 19273243.
      View in: PubMed
    27. Agarkov A, Gilbertson SR. Preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. J Comb Chem. 2008 Sep-Oct; 10(5):655-7. PMID: 18611055.
      View in: PubMed
    28. Kots AY, Choi BK, Estrella-Jimenez ME, Warren CA, Gilbertson SR, Guerrant RL, Murad F. Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8440-5. PMID: 18559851.
      View in: PubMed
    29. Jimenez ME, Bush K, Pawlik J, Sower L, Peterson JW, Gilbertson SR. Synthesis and screening of small molecule inhibitors of anthrax edema factor. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4215-8. PMID: 18539457.
      View in: PubMed
    30. Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE. Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem. 2008 May 09; 283(19):12870-6. PMID: 18308731.
      View in: PubMed
    31. Agarkov A, Chauhan S, Lory PJ, Gilbertson SR, Motin VL. Substrate specificity and screening of the integral membrane protease Pla. Bioorg Med Chem Lett. 2008 Jan 01; 18(1):427-31. PMID: 17981463.
      View in: PubMed
    32. Lory PM, Estrella-Jimenez ME, Shashack MJ, Lokesh GL, Natarajan A, Gilbertson SR. Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides. Bioorg Med Chem Lett. 2007 Nov 01; 17(21):5940-3. PMID: 17826998.
      View in: PubMed
    33. DeBoef B, Counts WR, Gilbertson SR. Rhodium-catalyzed synthesis of eight-membered rings. J Org Chem. 2007 Feb 02; 72(3):799-804. PMID: 17253798.
      View in: PubMed
    34. Agarkov A, Greenfield S, Xie D, Pawlick R, Starkey G, Gilbertson SR. Synthesis of phosphine containing amino acids: utilization of peptide synthesis in ligand design. Biopolymers. 2006; 84(1):48-73. PMID: 16235230.
      View in: PubMed
    35. Xu G, Gilbertson SR. Development of building blocks for the synthesis of N-heterocyclic carbene ligands. Org Lett. 2005 Oct 13; 7(21):4605-8. PMID: 16209490.
      View in: PubMed
    36. Agarkov A, Greenfield SJ, Ohishi T, Collibee SE, Gilbertson SR. Catalysis with phosphine-containing amino acids in various "turn" motifs. J Org Chem. 2004 Nov 12; 69(23):8077-85. PMID: 15527293.
      View in: PubMed
    37. Greenfield SJ, Agarkov A, Gilbertson SR. High asymmetric induction with beta-turn-derived palladium phosphine complexes. Org Lett. 2003 Aug 21; 5(17):3069-72. PMID: 12916983.
      View in: PubMed
    38. Agarkov A, Uffman EW, Gilbertson SR. Parallel approach to selective catalysts for palladium-catalyzed desymmetrization of 2,4-cyclopentenediol. Org Lett. 2003 Jun 12; 5(12):2091-4. PMID: 12790536.
      View in: PubMed
    39. Gilbertson SR, DeBoef B. Rhodium catalyzed [4 + 2 + 2] cycloaddition and alkyne insertion: a new route to eight-membered rings. J Am Chem Soc. 2002 Jul 31; 124(30):8784-5. PMID: 12137517.
      View in: PubMed
    40. Gilbertson SR, Starkey GW. Palladium-Catalyzed Synthesis of Phosphine-Containing Amino Acids. J Org Chem. 1996 May 03; 61(9):2922-2923. PMID: 11667143.
      View in: PubMed
    41. Gilbertson SR, Wang X. Synthesis of (Dicyclohexylphosphino)serine, Its Incorporation into a Dodecapeptide, and the Coordination of Rhodium. J Org Chem. 1996 Jan 26; 61(2):434-435. PMID: 11666953.
      View in: PubMed
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