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ROMI GHOSE

TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
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    K01DK076057     (GHOSE, ROMI)Aug 22, 2006 - Jul 31, 2012
    NIH/NIDDK
    Hepatic drug metabolism in inflammation
    Role: Principal Investigator

    R21DA035751     (GHOSE, ROMI)Mar 15, 2014 - Feb 29, 2016
    NIH/NIDA
    Novel in vivo regulatory mechanisms of human CYP3A4
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Taneja G, Maity S, Jiang W, Moorthy B, Coarfa C, Ghose R. Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene. Sci Rep. 2019 Apr 30; 9(1):6663. PMID: 31040347.
      View in: PubMed
    2. Paranjpe R, Basatneh D, Tao G, De Angelis C, Noormohammed S, Ekinci E, Abughosh S, Ghose R, Trivedi MV. Neratinib in HER2-Positive Breast Cancer Patients. Ann Pharmacother. 2019 Jun; 53(6):612-620. PMID: 30607980.
      View in: PubMed
    3. Sun R, Basu S, Zeng M, Sunsong R, Li L, Ghose R, Wang W, Liu Z, Hu M, Gao S. Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Curr Cancer Drug Targets. 2019; 19(7):551-560. PMID: 31509102.
      View in: PubMed
    4. Mallick P, Shah P, Ittmann MM, Trivedi M, Hu M, Gao S, Ghose R. Impact of diet on irinotecan toxicity in mice. Chem Biol Interact. 2018 Aug 01; 291:87-94. PMID: 29913120.
      View in: PubMed
    5. Taneja G, Chu C, Maturu P, Moorthy B, Ghose R. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro. Drug Metab Dispos. 2018 04; 46(4):397-404. PMID: 29440179.
      View in: PubMed
    6. Myers AL, Kawedia JD, Champlin RE, Kramer MA, Nieto Y, Ghose R, Andersson BS. Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opin Drug Metab Toxicol. 2017 Sep; 13(9):901-923. PMID: 28766962.
      View in: PubMed
    7. Mallick P, Basu S, Moorthy B, Ghose R. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Jun; 41:75-82. PMID: 28242239.
      View in: PubMed
    8. Mallick P, Taneja G, Moorthy B, Ghose R. Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun; 13(6):605-616. PMID: 28537216.
      View in: PubMed
    9. Ghose R, Mallick P, Taneja G, Chu C, Moorthy B. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016; 1395:55-68. PMID: 26910068.
      View in: PubMed
    10. Shah P, Omoluabi O, Moorthy B, Ghose R. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon ß in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan; 44(1):61-7. PMID: 26470915.
      View in: PubMed
    11. Mallick P, Shah P, Gandhi A, Ghose R. Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice. Life Sci. 2015 Oct 15; 139:132-8. PMID: 26334566.
      View in: PubMed
    12. Shah P, Guo T, Moore DD, Ghose R. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metab Dispos. 2014 Jan; 42(1):172-81. PMID: 24194512.
      View in: PubMed
    13. Gandhi A, Moorthy B, Ghose R. Drug disposition in pathophysiological conditions. Curr Drug Metab. 2012 Nov; 13(9):1327-44. PMID: 22746301.
      View in: PubMed
    14. Gandhi A, Shah P, Guo T, Moorthy B, Chow S-L. D, Hu M & Ghose R. Altered pharmacokinetics and pharmacodynamics of the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins. British Journal of Pharmacology. 2012; 166(7):2167-87.
    15. Fahy BN, Guo T, Ghose R. Impact of hepatic malignancy on CYP3A4 gene expression. J Surg Res. 2012 Dec; 178(2):768-72. PMID: 22763214.
      View in: PubMed
    16. Gandhi A and Ghose R. . Altered Drug Metabolism and Transport in Pathophysiological Conditions. 2012.
    17. Ghose R, Omoluabi O, Gandhi A, Shah P, Strohacker K, Carpenter KC, McFarlin B, Guo T. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011 Jul 04; 89(1-2):57-64. PMID: 21620874.
      View in: PubMed
    18. Ghose R, Guo T, Vallejo JG, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81. PMID: 21303924.
      View in: PubMed
    19. Gandhi A, Guo T, Ghose R. Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes. J Toxicol Sci. 2010 Apr; 35(2):163-73. PMID: 20371967.
      View in: PubMed
    20. Tam VH, Ledesma KR, Schilling AN, Lim TP, Yuan Z, Ghose R, Lewis RE. In vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing. Diagn Microbiol Infect Dis. 2009 Aug; 64(4):427-33. PMID: 19631096.
      View in: PubMed
    21. Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch Biochem Biophys. 2009 Jan 01; 481(1):123-30. PMID: 18940178.
      View in: PubMed
    22. Ghose R, White D, Guo T, Vallejo J, Karpen SJ. Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos. 2008 Jan; 36(1):95-101. PMID: 17932222.
      View in: PubMed
    23. Ghose, R., J. Mulder and S. J. Karpen. Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPAR? agonist, Rosiglitazone. J Hepatol. 2007; 46(1):115-123.
    24. Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJ. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J Biol Chem. 2006 Jun 02; 281(22):15434-40. PMID: 16551633.
      View in: PubMed
    25. Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept. 2004 Aug 16; 2(1):4. PMID: 15312234.
      View in: PubMed
    26. Ghose R, Malik M, Huber PW. Restricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes. Mol Cell Biol. 2004 Mar; 24(6):2467-77. PMID: 14993284.
      View in: PubMed
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