TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 7045
Houston, TX 77204-5037
Houston TX 77204-5037
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    K01DK076057     (GHOSE, ROMI)Aug 22, 2006 - Jul 31, 2012
    Hepatic drug metabolism in inflammation
    Role: Principal Investigator

    R21DA035751     (GHOSE, ROMI)Mar 15, 2014 - Feb 28, 2019
    Novel in vivo regulatory mechanisms of human CYP3A4
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jonsson-Schmunk K, Ghose R, Croyle MA. Immunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A. Expert Rev Vaccines. 2021 05; 20(5):623-634. PMID: 33666138.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    2. Tao G, Huang J, Moorthy B, Wang C, Hu M, Gao S, Ghose R. Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity. Expert Opin Drug Metab Toxicol. 2020 Nov; 16(11):1109-1124. PMID: 32841068.
      Citations: 1     Fields:    Translation:HumansCells
    3. Sun R, Zhu L, Li L, Song W, Gong X, Qi X, Wang Y, Ghose R, Gao S, Hu M, Liu Z. Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt. Toxicol Appl Pharmacol. 2020 07 01; 398:115032. PMID: 32387182.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Chityala PK, Wu L, Chow DS, Ghose R. Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model. Chem Biol Interact. 2020 Jan 25; 316:108933. PMID: 31870839.
      Citations:    Fields:    Translation:Animals
    5. Taneja G, Maity S, Jiang W, Moorthy B, Coarfa C, Ghose R. Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene. Sci Rep. 2019 04 30; 9(1):6663. PMID: 31040347.
      Citations: 3     Fields:    Translation:AnimalsCells
    6. Paranjpe R, Basatneh D, Tao G, De Angelis C, Noormohammed S, Ekinci E, Abughosh S, Ghose R, Trivedi MV. Neratinib in HER2-Positive Breast Cancer Patients. Ann Pharmacother. 2019 06; 53(6):612-620. PMID: 30607980.
      Citations: 8     Fields:    Translation:Humans
    7. Sun R, Basu S, Zeng M, Sunsong R, Li L, Ghose R, Wang W, Liu Z, Hu M, Gao S. Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea. Curr Cancer Drug Targets. 2019; 19(7):551-560. PMID: 31509102.
      Citations:    Fields:    Translation:Animals
    8. Mallick P, Shah P, Ittmann MM, Trivedi M, Hu M, Gao S, Ghose R. Impact of diet on irinotecan toxicity in mice. Chem Biol Interact. 2018 Aug 01; 291:87-94. PMID: 29913120.
      Citations: 3     Fields:    Translation:Animals
    9. Taneja G, Chu C, Maturu P, Moorthy B, Ghose R. Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro. Drug Metab Dispos. 2018 04; 46(4):397-404. PMID: 29440179.
      Citations: 5     Fields:    Translation:HumansCells
    10. Myers AL, Kawedia JD, Champlin RE, Kramer MA, Nieto Y, Ghose R, Andersson BS. Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review. Expert Opin Drug Metab Toxicol. 2017 Sep; 13(9):901-923. PMID: 28766962.
      Citations: 17     Fields:    Translation:HumansAnimals
    11. Mallick P, Basu S, Moorthy B, Ghose R. Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro. Toxicol In Vitro. 2017 Jun; 41:75-82. PMID: 28242239.
      Citations: 3     Fields:    Translation:AnimalsCells
    12. Mallick P, Taneja G, Moorthy B, Ghose R. Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions. Expert Opin Drug Metab Toxicol. 2017 Jun; 13(6):605-616. PMID: 28537216.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Ghose R, Mallick P, Taneja G, Chu C, Moorthy B. In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin. Methods Mol Biol. 2016; 1395:55-68. PMID: 26910068.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    14. Shah P, Omoluabi O, Moorthy B, Ghose R. Role of Adaptor Protein Toll-Like Interleukin Domain Containing Adaptor Inducing Interferon ß in Toll-Like Receptor 3- and 4-Mediated Regulation of Hepatic Drug Metabolizing Enzyme and Transporter Genes. Drug Metab Dispos. 2016 Jan; 44(1):61-7. PMID: 26470915.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Mallick P, Shah P, Gandhi A, Ghose R. Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice. Life Sci. 2015 Oct 15; 139:132-8. PMID: 26334566.
      Citations: 6     Fields:    Translation:HumansAnimals
    16. Shah P, Guo T, Moore DD, Ghose R. Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metab Dispos. 2014 Jan; 42(1):172-81. PMID: 24194512.
      Citations: 15     Fields:    Translation:AnimalsCells
    17. Gandhi A, Moorthy B, Ghose R. Drug disposition in pathophysiological conditions. Curr Drug Metab. 2012 Nov; 13(9):1327-44. PMID: 22746301.
      Citations: 23     Fields:    Translation:HumansAnimals
    18. Gandhi A, Shah P, Guo T, Moorthy B, Chow S-L. D, Hu M & Ghose R. Altered pharmacokinetics and pharmacodynamics of the CYP3A substrate, midazolam, during hepatic inflammation induced by bacterial endotoxins. British Journal of Pharmacology. 2012; 166(7):2167-87.
    19. Fahy BN, Guo T, Ghose R. Impact of hepatic malignancy on CYP3A4 gene expression. J Surg Res. 2012 Dec; 178(2):768-72. PMID: 22763214.
      Citations: 3     Fields:    Translation:Humans
    20. Gandhi A and Ghose R. . Altered Drug Metabolism and Transport in Pathophysiological Conditions. 2012.
    21. Ghose R, Omoluabi O, Gandhi A, Shah P, Strohacker K, Carpenter KC, McFarlin B, Guo T. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 2011 Jul 04; 89(1-2):57-64. PMID: 21620874.
      Citations: 32     Fields:    Translation:Animals
    22. Ghose R, Guo T, Vallejo JG, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81. PMID: 21303924.
      Citations: 17     Fields:    Translation:AnimalsCells
    23. Gandhi A, Guo T, Ghose R. Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes. J Toxicol Sci. 2010 Apr; 35(2):163-73. PMID: 20371967.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Tam VH, Ledesma KR, Schilling AN, Lim TP, Yuan Z, Ghose R, Lewis RE. In vivo dynamics of carbapenem-resistant Pseudomonas aeruginosa selection after suboptimal dosing. Diagn Microbiol Infect Dis. 2009 Aug; 64(4):427-33. PMID: 19631096.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Ghose R, Guo T, Haque N. Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid. Arch Biochem Biophys. 2009 Jan 01; 481(1):123-30. PMID: 18940178.
      Citations: 14     Fields:    Translation:AnimalsCells
    26. Ghose R, White D, Guo T, Vallejo J, Karpen SJ. Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos. 2008 Jan; 36(1):95-101. PMID: 17932222.
      Citations: 15     Fields:    Translation:AnimalsCells
    27. Ghose, R., J. Mulder and S. J. Karpen. Lipoplolysaccharide-mediated down-regulation of hepatic genes is ameliorated by the PPAR? agonist, Rosiglitazone. J Hepatol. 2007; 46(1):115-123.
    28. Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJ. Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J Biol Chem. 2006 Jun 02; 281(22):15434-40. PMID: 16551633.
      Citations: 46     Fields:    Translation:HumansCells
    29. Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation. Nucl Recept. 2004 Aug 16; 2(1):4. PMID: 15312234.
      Citations: 60     
    30. Ghose R, Malik M, Huber PW. Restricted specificity of Xenopus TFIIIA for transcription of somatic 5S rRNA genes. Mol Cell Biol. 2004 Mar; 24(6):2467-77. PMID: 14993284.
      Citations: 2     Fields:    Translation:AnimalsCells
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