TitleAssociate Professor. Assistant Dean of Graduate Programs
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 6007D
Houston, TX 77204-5039
Houston TX 77204-5039
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    R01CA039792     (KNOLL, BRIAN J)Apr 1, 1985 - Mar 31, 1988
    Role: Principal Investigator

    R01CA046763     (KNOLL, BRIAN J)Feb 1, 1988 - Aug 31, 1991
    Role: Principal Investigator

    R01HL050047     (KNOLL, BRIAN J)Jul 10, 1994 - May 31, 2004
    Role: Principal Investigator

    R01HL057445     (KNOLL, BRIAN J)Dec 7, 1998 - Nov 30, 2001
    Role: Principal Investigator

    R56AI079236     (BOND, RICHARD AGUSTIN)Apr 15, 2012 - Sep 30, 2014
    Mechanisms of Beta-blocker Induced Improvements in Asthma
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nguyen LP, Al-Sawalha NA, Parra S, Pokkunuri I, Omoluabi O, Okulate AA, Windham Li E, Hazen M, Gonzalez-Granado JM, Daly CJ, McGrath JC, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. ß2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9163-E9171. PMID: 29073113.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    2. Joshi R, Valdez D, Kim H, Eikenburg DC, Knoll BJ, Bond RA. Effects of ß-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype. Pulm Pharmacol Ther. 2017 Oct; 46:30-40. PMID: 28729042.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Forkuo GS, Kim H, Thanawala VJ, Al-Sawalha N, Valdez D, Joshi R, Parra S, Pera T, Gonnella PA, Knoll BJ, Walker JK, Penn RB, Bond RA. Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by ß2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. Am J Respir Cell Mol Biol. 2016 08; 55(2):234-42. PMID: 26909542.
      Citations: 8     Fields:    Translation:AnimalsCells
    4. Thanawala VJ, Valdez DJ, Joshi R, Forkuo GS, Parra S, Knoll BJ, Bouvier M, Leff P, Bond RA. ß-Blockers have differential effects on the murine asthma phenotype. Br J Pharmacol. 2015 Oct; 172(20):4833-46. PMID: 26211486.
      Citations: 12     Fields:    Translation:Animals
    5. Al-Sawalha N, Pokkunuri I, Omoluabi O, Kim H, Thanawala VJ, Hernandez A, Bond RA, Knoll BJ. Epinephrine Activation of the ß2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells. PLoS One. 2015; 10(7):e0132559. PMID: 26161982.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    6. Al-Sawalha, N, Pokkunuri, I, Omoluabi, O, Kim, H, Thanawala, VJ, Hernandez, A Bond, RA Knoll, BJ. Epinephrine activation of the ß2-adrenoceptor is required for IL-13 induced mucin production in human bronchial epithelial cells. PLoS One. 2015; 10(7):E0132559.
    7. Thanawala JT, Forkuo GS, Al-Sawalha N, Azzegagh Z, Nguyen LP, Eriksen JL, Tuvim MJ, Lowder TW, Dickey BF, Knoll BJ, Walker JKL, Bond RA. ß2-adrenoceptor agonists are required for development of the asthma phenotype in a murine model. Am. J. Resp. Cell Molec. Biol. 2013; 48:220-229.
    8. Peng H, Bond RA, Knoll BJ. The effects of acute and chronic nadolol treatment on ß2AR signaling in HEK293 cells. Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb; 383(2):209-16. PMID: 21225244.
      Citations: 2     Fields:    Translation:HumansCells
    9. Awwad HO, Millman EE, Alpizar-Foster E, Moore RH, Knoll BJ. Mutating the dileucine motif of the human beta(2)-adrenoceptor reduces the high initial rate of receptor phosphorylation by GRK without affecting postendocytic sorting. Eur J Pharmacol. 2010 Jun 10; 635(1-3):9-15. PMID: 20193676.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2435-40. PMID: 19171883.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    11. Millman EE, Zhang H, Zhang H, Godines V, Bean AJ, Knoll BJ, Moore RH. Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb. Traffic. 2008 Nov; 9(11):1958-71. PMID: 18785920.
      Citations: 19     Fields:    Translation:HumansCells
    12. Nguyen LP, Omoluabi O, Parra S, Frieske JM, Clement C, Ammar-Aouchiche Z, Ho SB, Ehre C, Kesimer M, Knoll BJ, Tuvim MJ, Dickey BF, Bond RA. Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):256-62. PMID: 18096872.
      Citations: 59     Fields:    Translation:Animals
    13. Lin R, Peng H, Nguyen LP, Dudekula NB, Shardonofsky F, Knoll BJ, Parra S, Bond RA. Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther. 2008; 21(1):115-24. PMID: 17689122.
      Citations: 35     Fields:    Translation:Animals
    14. Awwad HO, Iyer V, Rosenfeld JL, Millman EE, Foster E, Moore RH, Knoll BJ. Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors. Exp Cell Res. 2007 Jul 15; 313(12):2586-96. PMID: 17553490.
      Citations: 3     Fields:    Translation:HumansCells
    15. Tran TM, Friedman J, Baameur F, Knoll BJ, Moore RH, Clark RB. Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Mol Pharmacol. 2007 Jan; 71(1):47-60. PMID: 17012621.
      Citations: 25     Fields:    Translation:HumansCells
    16. Moore RH, Millman EE, Godines V, Hanania NA, Tran TM, Peng H, Dickey BF, Knoll BJ, Clark RB. Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):254-61. PMID: 16980556.
      Citations: 26     Fields:    Translation:HumansCells
    17. Iyer V, Tran TM, Foster E, Dai W, Clark RB, Knoll BJ. Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol. 2006 Feb; 147(3):249-59. PMID: 16331289.
      Citations: 27     Fields:    Translation:HumansCells
    18. Vaughan DJ, Millman EE, Godines V, Friedman J, Tran TM, Dai W, Knoll BJ, Clark RB, Moore RH. Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem. 2006 Mar 17; 281(11):7684-92. PMID: 16407241.
      Citations: 34     Fields:    Translation:HumansCells
    19. Callaerts-Vegh Z, Evans KL, Dudekula N, Cuba D, Knoll BJ, Callaerts PF, Giles H, Shardonofsky FR, Bond RA. Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4948-53. PMID: 15069206.
      Citations: 62     Fields:    Translation:AnimalsCells
    20. Moore RH, Millman EE, Alpizar-Foster E, Dai W, Knoll BJ. Rab11 regulates the recycling and lysosome targeting of ß2-adrenergic receptors. J. Cell Sci. 2004; 117:3107-3117.
    21. Millman EE, Rosenfeld JL, Vaughan DJ, Nguyen J, Dai W, Alpizar-Foster E, Clark RB, Knoll BJ, Moore RH. Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Br J Pharmacol. 2004 Jan; 141(2):277-84. PMID: 14691047.
      Citations: 7     Fields:    Translation:HumansCells
    22. Liu Q, Reubi JC, Wang Y, Knoll BJ, Schonbrunn A. In vivo phosphorylation of the somatostatin 2A receptor in human tumors. J Clin Endocrinol Metab. 2003 Dec; 88(12):6073-9. PMID: 14671213.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Moore RH, Knoll, BJ. Therapeutic Targets in Airway Inflammation (Eissa NT, Huston D, eds). Cellular Trafficking of ß2-adrenergic Receptors. 2003.
    24. Rosenfeld JL, Knoll BJ, Moore RH. Regulation of G-protein-coupled receptor activity by rab GTPases. Recept Channels. 2002; 8(2):87-97. PMID: 12448790.
      Citations: 11     Translation:HumansAnimalsCells
    25. Clark RB, Knoll BJ. Measurement of receptor desensitization and internalization in intact cells. Methods Enzymol. 2002; 343:506-29. PMID: 11665589.
      Citations: 4     Fields:    Translation:HumansCells
    26. Rosenfeld JL, Moore RH, Zimmer KP, Alpizar-Foster E, Dai W, Zarka MN, Knoll BJ. Lysosome proteins are redistributed during expression of a GTP-hydrolysis-defective rab5a. J Cell Sci. 2001 Dec; 114(Pt 24):4499-508. PMID: 11792815.
      Citations: 23     Fields:    Translation:HumansCells
    27. Seibold A, Williams B, Huang ZF, Friedman J, Moore RH, Knoll BJ, Clark RB. Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway. Mol Pharmacol. 2000 Nov; 58(5):1162-73. PMID: 11040066.
      Citations: 42     Fields:    Translation:HumansCells
    28. Hoffenberg S, Liu X, Nikolova L, Hall HS, Dai W, Baughn RE, Dickey BF, Barbieri MA, Aballay A, Stahl PD, Knoll BJ. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. J Biol Chem. 2000 Aug 11; 275(32):24661-9. PMID: 10818110.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    29. Clark RB, Knoll BJ, Barber R. Partial agonists and G protein-coupled receptor desensitization. Trends Pharmacol Sci. 1999 Jul; 20(7):279-86. PMID: 10390646.
      Citations: 40     Fields:    
    30. Moore RH, Hall HS, Rosenfeld JL, Dai W, Knoll BJ. Specific changes in beta2-adrenoceptor trafficking kinetics and intracellular sorting during downregulation. Eur J Pharmacol. 1999 Mar 12; 369(1):113-23. PMID: 10204689.
      Citations: 5     Fields:    Translation:HumansCells
    31. Moore RH, Tuffaha A, Millman EE, Dai W, Hall HS, Dickey BF, Knoll BJ. Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation. J Cell Sci. 1999 Feb; 112 ( Pt 3):329-38. PMID: 9885286.
      Citations: 26     Fields:    Translation:HumansCells
    32. Tuvim MJ, Adachi R, Chocano JF, Moore RH, Lampert RM, Zera E, Romero E, Knoll BJ, Dickey BF. Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis. Am J Respir Cell Mol Biol. 1999 Jan; 20(1):79-89. PMID: 9870920.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    33. January B, Seibold A, Allal C, Whaley BS, Knoll BJ, Moore RH, Dickey BF, Barber R, Clark RB. Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor. Br J Pharmacol. 1998 Feb; 123(4):701-11. PMID: 9517390.
      Citations: 23     Fields:    Translation:HumansCells
    34. Morrison KJ, Moore RH, Carsrud ND, Trial J, Millman EE, Tuvim M, Clark RB, Barber R, Dickey BF, Knoll BJ. Repetitive endocytosis and recycling of the beta 2-adrenergic receptor during agonist-induced steady state redistribution. Mol Pharmacol. 1996 Sep; 50(3):692-9. PMID: 8794912.
      Citations: 20     Fields:    Translation:Humans
    35. Hoffenberg S, Nikolova L, Pan JY, Daniel DS, Wessling-Resnick M, Knoll BJ, Dickey BF. Functional and structural interactions of the Rab5 D136N mutant with xanthine nucleotides. Biochem Biophys Res Commun. 1995 Oct 04; 215(1):241-9. PMID: 7575598.
      Citations: 9     Fields:    Translation:HumansCells
    36. Ghebranious N, Knoll BJ, Yavorkovsky L, Ilic Z, Papaconstantinou J, Lozano G, Sell S. Developmental control of transcription of the CAT reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice. Mol Reprod Dev. 1995 Sep; 42(1):1-6. PMID: 8562043.
      Citations: 1     Fields:    Translation:AnimalsCells
    37. Ghebranious N, Knoll BJ, Wu H, Lozano G, Sell S. Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Mol Carcinog. 1995 Jun; 13(2):104-11. PMID: 7605578.
      Citations:    Fields:    Translation:HumansAnimalsCells
    38. Hoffenberg S, Sanford JC, Liu S, Daniel DS, Tuvin M, Knoll BJ, Wessling-Resnick M, Dickey BF. Biochemical and functional characterization of a recombinant GTPase, Rab5, and two of its mutants. J Biol Chem. 1995 Mar 10; 270(10):5048-56. PMID: 7890612.
      Citations: 19     Fields:    Translation:HumansCells
    39. Ghebranious, N, Knoll, BJ, Wu,H, Lozano, G Sell, S . Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Molec. Carcinog. 1995; 13:104-111.
    40. Mathew, J., Knoll BJ, Pillai, A, Durham, D, Sell S. . Discrete cell-type specific enhancer regions 5' of the rat alphafetoprotein gene: Identification of a highly active distal enhancer. J. Tumor Marker Oncology. 1994; 9:21-28.
    41. Knoll BJ. Gene expression in the human placental trophoblast: a model for developmental gene regulation. Placenta. 1992 Jul-Aug; 13(4):311-27. PMID: 1332019.
      Citations:    Fields:    Translation:HumansAnimalsCells
    42. Povinelli CM, Stewart JM, Knoll BJ. Differential and coordinate responses of the human genes encoding the heat stable alkaline phosphatases to cAMP and sodium butyrate in the choriocarcinoma line JEG-3. Biochim Biophys Acta. 1992 Jan 23; 1115(3):243-51. PMID: 1739739.
      Citations: 2     Fields:    Translation:HumansCells
    43. Sell, S, Knoll, BJ. The Role of Cell Types in Hepatocarcinogenesis (Sirica, AE, ed). Transgenic mouse models of hepatocarcinogenesis. 1992; 299-321.
    44. Povinelli CM, Knoll BJ. Trace expression of the germ-cell alkaline phosphatase gene in human placenta. Placenta. 1991 Nov-Dec; 12(6):663-8. PMID: 1725215.
      Citations: 2     Fields:    Translation:HumansCells
    45. Knoll BJ, Rothblum KN, Longley M. Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution. J Biol Chem. 1988 Aug 25; 263(24):12020-7. PMID: 3042787.
      Citations: 19     Fields:    Translation:HumansCells
    46. Sell S, Hunt JM, Knoll BJ, Dunsford HA. Cellular events during hepatocarcinogenesis in rats and the question of premalignancy. Adv Cancer Res. 1987; 48:37-111. PMID: 2441577.
      Citations: 14     Fields:    Translation:AnimalsCells
    47. Knoll, BJ, Rothblum, KN, Longley, M. Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. Gene. 1987; 60:267-276.
    48. Henthorn PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H. Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5597-601. PMID: 3461452.
      Citations: 26     Fields:    Translation:HumansCells
    49. Knoll BJ, Longley M, Sell S. Cloning of a cDNA encoding the rat placental glutathione S-transferase: overproduction of the mRNA in hepatocellular carcinomas. Tumour Biol. 1986; 7(2-3):123-35. PMID: 3797960.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Dean DC, Gope R, Knoll BJ, Riser ME, O'Malley BW. A similar 5'-flanking region is required for estrogen and progesterone induction of ovalbumin gene expression. J Biol Chem. 1984 Aug 25; 259(16):9967-70. PMID: 6088508.
      Citations: 5     Fields:    Translation:AnimalsCells
    51. Knoll BJ, Zarucki-Schulz T, Dean DC, O'Malley BW. Definition of the ovalbumin gene promoter by transfer of an ovalglobin fusion gene into cultured cells. Nucleic Acids Res. 1983 Oct 11; 11(19):6733-54. PMID: 6314256.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    52. Dean DC, Knoll BJ, Riser ME, O'Malley BW. A 5'-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene. Nature. 1983 Oct 6-12; 305(5934):551-4. PMID: 6621702.
      Citations: 30     Fields:    Translation:AnimalsCells
    53. Lawson GM, Knoll BJ, March CJ, Woo SL, Tsai MJ, O'Malley BW. Definition of 5' and 3' structural boundaries of the chromatin domain containing the ovalbumin multigene family. J Biol Chem. 1982 Feb 10; 257(3):1501-7. PMID: 6276388.
      Citations: 40     Fields:    Translation:AnimalsCells
    54. Knoll BJ, Woo SL, Beattie W, O'Malley BW. Identification and sequence analysis of the 5' domain of the X and Y pseudo-ovalbumin genes. J Biol Chem. 1981 Aug 10; 256(15):7949-53. PMID: 6267030.
      Citations: 5     Fields:    Translation:AnimalsCells
    55. Cohen,S, Knoll, BJ, Little, JW, Mount, DW. Preferential cleavage of phage lamdda repressor monomers by recA protease. . Nature. 1981; 294:182-184.
    56. Colbert DA, Knoll BJ, Woo SL, Mace ML, Tsai MJ, O'Malley BW. Differential hormonal responsiveness of the ovalbumin gene and its pseudogenes in the chick oviduct. Biochemistry. 1980 Nov 25; 19(24):5586-92. PMID: 6257282.
      Citations: 7     Fields:    Translation:AnimalsCells
    57. Knoll BJ. Interactions of the lambda cIIIs1 and E. coli hfl-1 mutations. Virology. 1980 Aug; 105(1):270-2. PMID: 6447936.
      Citations: 1     Fields:    Translation:Cells
    58. Knoll, BJ. An analysis of repressor overproduction by the lambda cIIIs mutant. J. Molec. Biol. 1979; 132:551-555.
    59. Knoll, BJ. Isolation and characterization of mutations in the cIII gene of bacteriophage lambda which increase the efficiency of lysogenization of Escherichia coli K-12. J. Virology. 1979; 92(518):531.
    60. Knoll B. Strain differences in escape responses of rats. Act Nerv Super (Praha). 1972 Nov; 14(4):293. PMID: 5083832.
      Citations:    Fields:    Translation:Animals
    61. Knoll J, Ecseri Z, Kelemen K, Nievel J, Knoll B. Phenylisopropylmethylpropinylamine (E-250), a new spectrum psychic energizer. Arch Int Pharmacodyn Ther. 1965 May; 155(1):154-64. PMID: 4378644.
      Citations: 25     Fields:    Translation:Animals
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