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BRADLEY K. MCCONNELL

TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
Address460 Science and Research Building 2
Houston TX 77204-5037
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    Collapse Research 
    Collapse research activities and funding
    R01HL085487     (MCCONNELL, BRADLEY K)Sep 30, 2007 - Mar 31, 2014
    NIH/NHLBI
    Targeted Disruption of Beta-Adrenergic Signaling to Increase Cardiac Contractilit
    Role: Principal Investigator

    R15HL124458     (MCCONNELL, BRADLEY K)Apr 1, 2015 - Mar 31, 2018
    NIH/NHLBI
    Scaffolding Protein Interaction Network Regulates Cardiac Cell Signaling
    Role: Principal Investigator

    R15HL141963     (MCCONNELL, BRADLEY K)Apr 1, 2019 - Mar 31, 2022
    NIH/NHLBI
    Gravin Signalosome Protein Coordinates Cardiac Function via Adrenergic Receptor Signaling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang P, Guan Y, Chen J, Li X, McConnell BK, Zhou W, Boini KM, Zhang Y. Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene. Cell Death Dis. 2018 Nov 19; 9(12):1145. PMID: 30451833.
      View in: PubMed
    2. Raghunathan S, Reynolds CL, Schwartz RJ, Stewart MD, McConnell BK. C.B-17 SCID mice develop epicardial calcinosis with unaltered cardiac function. Fundam Clin Pharmacol. 2019 Feb; 33(1):25-30. PMID: 29959870.
      View in: PubMed
    3. Suryavanshi SV, Jadhav SM, Anderson KL, Katsonis P, Lichtarge O, McConnell BK. Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling. Am J Physiol Heart Circ Physiol. 2018 Jul 01; 315(1):H109-H121. PMID: 29600899.
      View in: PubMed
    4. Suryavanshi SV, Jadhav SM, McConnell BK. Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System. J Cardiovasc Dev Dis. 2018 Jan 25; 5(1). PMID: 29370121.
      View in: PubMed
    5. Li Z, Singh S, Suryavanshi SV, Ding W, Shen X, Wijaya CS, Gao WD, McConnell BK. Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice. Eur J Pharmacol. 2017 Jul 15; 807:117-126. PMID: 28428008.
      View in: PubMed
    6. Liu Y, Chen L, Diaz AD, Benham A, Xu X, Wijaya CS, Fa'ak F, Luo W, Soibam B, Azares A, Yu W, Lyu Q, Stewart MD, Gunaratne P, Cooney A, McConnell BK, Schwartz RJ. Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts. Sci Rep. 2016 08 19; 6:31457. PMID: 27538477.
      View in: PubMed
    7. Valenzuela N, Fan Q, Fa'ak F, Soibam B, Nagandla H, Liu Y, Schwartz RJ, McConnell BK, Stewart MD. Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016 Mar; 9(3):335-45. PMID: 26935106.
      View in: PubMed
    8. Rababa'h AM, Deo SV, Altarabsheh SE, De Caro J, Tarboush NA, Alzoubi KH, Ababneh M, McConnell BK, Markowitz AH, Park SJ. N-Acetyl Cysteine Therapy Does Not Prevent Renal Failure in High-Risk Patients Undergoing Open-Heart Surgery. Heart Surg Forum. 2016 Feb 22; 19(1):E16-22. PMID: 26913679.
      View in: PubMed
    9. McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SB. Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. Front Physiol. 2015; 6:242. PMID: 26379556.
      View in: PubMed
    10. Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CE. Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9046-51. PMID: 26153423.
      View in: PubMed
    11. Rababa'h A, Singh S, Suryavanshi SV, Altarabsheh SE, Deo SV, McConnell BK. Compartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy. Int J Mol Sci. 2014 Dec 24; 16(1):218-29. PMID: 25547489.
      View in: PubMed
    12. Motawea HK, Blazek AD, Zirwas MJ, Pleister AP, Ahmed AA, McConnell BK, Chotani MA. Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-a2C-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells. J Cytol Mol Biol. 2014 Jan 10; 1(1). PMID: 24701590.
      View in: PubMed
    13. Guillory AN, Yin X, Wijaya CS, Diaz Diaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BK. Enhanced cardiac function in Gravin mutant mice involves alterations in the ß-adrenergic receptor signaling cascade. PLoS One. 2013; 8(9):e74784. PMID: 24058627.
      View in: PubMed
    14. Rababa'h A, Craft JW, Wijaya CS, Atrooz F, Fan Q, Singh S, Guillory AN, Katsonis P, Lichtarge O, McConnell BK. Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol. 2013 Sep 23; 425(18):3277-88. PMID: 23806656.
      View in: PubMed
    15. Nguyen VT, Wu Y, Guillory AN, McConnell BK, Fujise K, Huang MH. Delta-opioid augments cardiac contraction through ß-adrenergic and CGRP-receptor co-signaling. Peptides. 2012 Jan; 33(1):77-82. PMID: 22108711.
      View in: PubMed
    16. Huang MH, Wu Y, Nguyen V, Rastogi S, McConnell BK, Wijaya C, Uretsky BF, Poh KK, Tan HC, Fujise K. Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion. Cardiovasc Drugs Ther. 2011 Jun; 25(3):223-32. PMID: 21562974.
      View in: PubMed
    17. Wu Y, Yin X, Wijaya C, Huang MH, McConnell BK. Acute myocardial infarction in rats. J Vis Exp. 2011 Feb 16; (48). PMID: 21372786.
      View in: PubMed
    18. McConnell BK, Popovic Z, Mal N, Lee K, Bautista J, Forudi F, Schwartzman R, Jin JP, Penn M, Bond M. Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis. J Biol Chem. 2009 Jan 16; 284(3):1583-92. PMID: 18945669.
      View in: PubMed
    19. Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1-2):73-80. PMID: 15524168.
      View in: PubMed
    20. Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1):73-80. PMID: 27520666.
      View in: PubMed
    21. Song Q, Schmidt AG, Hahn HS, Carr AN, Frank B, Pater L, Gerst M, Young K, Hoit BD, McConnell BK, Haghighi K, Seidman CE, Seidman JG, Dorn GW, Kranias EG. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J Clin Invest. 2003 Mar; 111(6):859-67. PMID: 12639992.
      View in: PubMed
    22. Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG. The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest. 2002 Apr; 109(8):1013-20. PMID: 11956238.
      View in: PubMed
    23. Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JG. Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene. Circulation. 2001 Nov 27; 104(22):2734-9. PMID: 11723028.
      View in: PubMed
    24. Sprung J, Ogletree-Hughes ML, McConnell BK, Zakhary DR, Smolsky SM, Moravec CS. The effects of propofol on the contractility of failing and nonfailing human heart muscles. Anesth Analg. 2001 Sep; 93(3):550-9. PMID: 11524317.
      View in: PubMed
    25. McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JG. Comparison of two murine models of familial hypertrophic cardiomyopathy. Circ Res. 2001 Mar 02; 88(4):383-9. PMID: 11230104.
      View in: PubMed
    26. Fatkin D, McConnell BK, Mudd JO, Semsarian C, Moskowitz IG, Schoen FJ, Giewat M, Seidman CE, Seidman JG. An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy. J Clin Invest. 2000 Dec; 106(11):1351-9. PMID: 11104788.
      View in: PubMed
    27. McConnell BK, Jones KA, Fatkin D, Arroyo LH, Lee RT, Aristizabal O, Turnbull DH, Georgakopoulos D, Kass D, Bond M, Niimura H, Schoen FJ, Conner D, Fischman DA, Seidman CE, Seidman JG. Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice J Clin Invest. 1999 Dec; 104(12):1771. PMID: 10606631.
      View in: PubMed
    28. Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, Yang G, Kudej A, McConnell BK, Seidman CE, Seidman JG, Vatner SF. An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. Am J Physiol. 1999 05; 276(5):H1780-7. PMID: 10330263.
      View in: PubMed
    29. Fatkin D, Christe ME, Aristizabal O, McConnell BK, Srinivasan S, Schoen FJ, Seidman CE, Turnbull DH, Seidman JG. Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene. J Clin Invest. 1999 Jan; 103(1):147-53. PMID: 9884344.
      View in: PubMed
    30. McConnell BK, Moravec CS, Bond M. Troponin I phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy. Am J Physiol. 1998 Feb; 274(2 Pt 2):H385-96. PMID: 9486239.
      View in: PubMed
    31. McConnell BK, Moravec CS, Morano I, Bond M. Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1440-51. PMID: 9321836.
      View in: PubMed
    32. Zhang BX, Ma X, McConnell BK, Damron DS, Bond M. Activation of purinergic receptors triggers oscillatory contractions in adult rat ventricular myocytes. Circ Res. 1996 Jul; 79(1):94-102. PMID: 8925574.
      View in: PubMed
    33. Xing M, Wilkins PL, McConnell BK, Mattera R. Regulation of phospholipase A2 activity in undifferentiated and neutrophil-like HL60 cells. Linkage between impaired responses to agonists and absence of protein kinase C-dependent phosphorylation of cytosolic phospholipase A2. J Biol Chem. 1994 Jan 28; 269(4):3117-24. PMID: 8300648.
      View in: PubMed
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