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ALEXANDER V. STATSYUK

TitleAssistant Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
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    Collapse Research 
    Collapse research activities and funding
    R01GM115632     (STATSYUK, ALEXANDER V)Jul 1, 2015 - Jun 30, 2020
    NIH/NIGMS
    Pharmacological Inhibitors of Nedd4 ubiquitin ligase as anticancer therapeutics
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Parker BW, Goncz EJ, Krist DT, Statsyuk AV, Nesvizhskii AI, Weiss EL. Mapping low-affinity/high-specificity peptide-protein interactions using ligand-footprinting mass spectrometry. Proc Natl Acad Sci U S A. 2019 Oct 02. PMID: 31578253.
      View in: PubMed
    2. Kathman SG, Statsyuk AV. Methodology for Identification of Cysteine-Reactive Covalent Inhibitors. Methods Mol Biol. 2019; 1967:245-262. PMID: 31069775.
      View in: PubMed
    3. Chowdhury SR, Kennedy S, Zhu K, Mishra R, Chuong P, Nguyen AU, Kathman SG, Statsyuk AV. Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments. Bioorg Med Chem Lett. 2019 01 01; 29(1):36-39. PMID: 30455147.
      View in: PubMed
    4. Ramirez YA, Adler TB, Altmann E, Klemm T, Tiesmeyer C, Sauer F, Kathman SG, Statsyuk AV, Sotriffer C, Kisker C. Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis. ChemMedChem. 2018 10 08; 13(19):2014-2023. PMID: 30028574.
      View in: PubMed
    5. Foote PK, Statsyuk AV. Monitoring PARKIN RBR Ubiquitin Ligase Activation States with UbFluor. Curr Protoc Chem Biol. 2018 09; 10(3):e45. PMID: 30063295.
      View in: PubMed
    6. Statsyuk AV. Let K-Ras activate its own inhibitor. Nat Struct Mol Biol. 2018 06; 25(6):435-437. PMID: 29760530.
      View in: PubMed
    7. Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep. 2018 01 23; 8(1):1405. PMID: 29362455.
      View in: PubMed
    8. Foote PK, Krist DT, Statsyuk AV. High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor. Curr Protoc Chem Biol. 2017 Sep 14; 9(3):174-195. PMID: 28910856.
      View in: PubMed
    9. Park S, Foote PK, Krist DT, Rice SE, Statsyuk AV. UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN. J Biol Chem. 2017 10 06; 292(40):16539-16553. PMID: 28710279.
      View in: PubMed
    10. Misra M, Kuhn M, Löbel M, An H, Statsyuk AV, Sotriffer C, Schindelin H. Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure. 2017 07 05; 25(7):1120-1129.e3. PMID: 28578874.
      View in: PubMed
    11. Krist DT, Foote PK, Statsyuk AV. UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis. Curr Protoc Chem Biol. 2017 03 02; 9(1):11-37. PMID: 28253433.
      View in: PubMed
    12. Krist DT, Park S, Boneh GH, Rice SE, Statsyuk AV. UbFluor: A Mechanism-Based Probe for HECT E3 Ligases. Chem Sci. 2016 Aug 01; 7(8):5587-5595. PMID: 27482366.
      View in: PubMed
    13. Kathman SG, Statsyuk AV. Covalent Tethering of Fragments For Covalent Probe Discovery. Medchemcomm. 2016 Apr 01; 7(4):576-585. PMID: 27398190.
      View in: PubMed
    14. An H, Statsyuk AV. Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis. Chem Commun (Camb). 2016 Feb 11; 52(12):2477-80. PMID: 26575161.
      View in: PubMed
    15. Kathman SG, Span I, Smith AT, Xu Z, Zhan J, Rosenzweig AC, Statsyuk AV. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J Am Chem Soc. 2015 Oct 07; 137(39):12442-5. PMID: 26371805.
      View in: PubMed
    16. McShan D, Kathman S, Lowe B, Xu Z, Zhan J, Statsyuk A, Ogungbe IV. Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain. Bioorg Med Chem Lett. 2015 Oct 15; 25(20):4509-12. PMID: 26342866.
      View in: PubMed
    17. Krist DT, Statsyuk AV. Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-Linkers. Biochemistry. 2015 Jul 28; 54(29):4411-4. PMID: 26161728.
      View in: PubMed
    18. An H, Statsyuk AV. An inhibitor of ubiquitin conjugation and aggresome formation. Chem Sci. 2015 Sep 01; 6(9):5235-5245. PMID: 28717502.
      View in: PubMed
    19. Park S, Krist DT, Statsyuk AV. Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes. Chem Sci. 2015 Mar 01; 6(3):1770-1779. PMID: 28706640.
      View in: PubMed
    20. Kathman SG, Xu Z, Statsyuk AV. A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases. J Med Chem. 2014 Jun 12; 57(11):4969-74. PMID: 24870364.
      View in: PubMed
    21. An H, Krist DT, Statsyuk AV. Crosstalk between kinases and Nedd4 family ubiquitin ligases. Mol Biosyst. 2014 Jul; 10(7):1643-57. PMID: 24457516.
      View in: PubMed
    22. An H, Statsyuk AV. Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways. J Am Chem Soc. 2013 Nov 13; 135(45):16948-62. PMID: 24138456.
      View in: PubMed
    23. Hong CM, Statsyuk AV. The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles. Org Biomol Chem. 2013 May 14; 11(18):2932-5. PMID: 23536160.
      View in: PubMed
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