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TitleAssociate Professor
InstitutionMD Anderson
DepartmentClinical Cancer Prevention
Address6767 Bertner St
Houston TX 77030-2603
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    Collapse Research 
    Collapse research activities and funding
    R01CA073678     (WU, XIANGWEI)Apr 1, 1997 - Mar 31, 2008
    Mechanisms of P53 Mediated Apoptosis and Carcinogenesis
    Role: Principal Investigator

    R01AI063063     (WU, XIANGWEI)Dec 15, 2004 - Nov 30, 2010
    Regulation of Cellular Response to TNF
    Role: Principal Investigator

    R01CA214954     (WU, XIANGWEI)Jun 12, 2018 - May 31, 2023
    Activating p53 for colorectal cancer prevention
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang H, Wu X. Detection and Enumeration of Circulating Tumor Cells with Invasive Phenotype. Adv Exp Med Biol. 2017; 994:133-141. PMID: 28560672.
      View in: PubMed
    2. Liu X, Wu X. Utilizing Matrigel Transwell Invasion Assay to Detect and Enumerate Circulating Tumor Cells. Methods Mol Biol. 2017; 1634:277-282. PMID: 28819859.
      View in: PubMed
    3. Davis JS, Gupta V, Gagea M, Wu X. An Advanced Histologic Method for Evaluation of Intestinal Adenomas in Mice Using Digital Slides. PLoS One. 2016; 11(3):e0151463. PMID: 26974326; PMCID: PMC4790911.
    4. Wang H, Hara Y, Liu X, Reuben JM, Xie Y, Xu H, Bu G, Pei Y, Gupta V, Wu X. Detection and enumeration of circulating tumor cells based on their invasive property. Oncotarget. 2015 Sep 29; 6(29):27304-11. PMID: 26247814; PMCID: PMC4694991.
    5. Wang H, Yang T, Wu X. 5-Fluorouracil preferentially sensitizes mutant KRAS non-small cell lung carcinoma cells to TRAIL-induced apoptosis. Mol Oncol. 2015 Nov; 9(9):1815-24. PMID: 26130327.
      View in: PubMed
    6. Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov. 2015 Jul; 5(7):752-67. PMID: 26069190; PMCID: PMC4497871.
    7. Lukianova-Hleb EY, Ren X, Sawant RR, Wu X, Torchilin VP, Lapotko DO. On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles. Nat Med. 2014 Jul; 20(7):778-784. PMID: 24880615; PMCID: PMC4271542.
    8. Wang H, Davis JS, Wu X. Immunoglobulin Fc domain fusion to TRAIL significantly prolongs its plasma half-life and enhances its antitumor activity. Mol Cancer Ther. 2014 Mar; 13(3):643-50. PMID: 24431076.
      View in: PubMed
    9. Lukianova-Hleb EY, Volkov AN, Wu X, Lapotko DO. Transient enhancement and spectral narrowing of the photothermal effect of plasmonic nanoparticles under pulsed excitation. Adv Mater. 2013 Feb 06; 25(5):772-6. PMID: 23161793; PMCID: PMC3772718.
    10. Lukianova-Hleb EY, Ren X, Townley D, Wu X, Kupferman ME, Lapotko DO. Plasmonic nanobubbles rapidly detect and destroy drug-resistant tumors. Theranostics. 2012; 2(10):976-87. PMID: 23139725; PMCID: PMC3493199.
    11. Davis JS, Wu X. Current state and future challenges of chemoprevention. Discov Med. 2012 May; 13(72):385-90. PMID: 22642920.
      View in: PubMed
    12. Lukianova-Hleb EY, Ren X, Constantinou PE, Danysh BP, Shenefelt DL, Carson DD, Farach-Carson MC, Kulchitsky VA, Wu X, Wagner DS, Lapotko DO. Improved cellular specificity of plasmonic nanobubbles versus nanoparticles in heterogeneous cell systems. PLoS One. 2012; 7(4):e34537. PMID: 22509318.
      View in: PubMed
    13. Lukianova-Hleb EY, Ren X, Zasadzinski JA, Wu X, Lapotko DO. Plasmonic nanobubbles enhance efficacy and selectivity of chemotherapy against drug-resistant cancer cells. Adv Mater. 2012 Jul 24; 24(28):3831-7. PMID: 22407874; PMCID: PMC3407535.
    14. Lukianova-Hleb EY, Belyanin A, Kashinath S, Wu X, Lapotko DO. Plasmonic nanobubble-enhanced endosomal escape processes for selective and guided intracellular delivery of chemotherapy to drug-resistant cancer cells. Biomaterials. 2012 Feb; 33(6):1821-6. PMID: 22137124; PMCID: PMC3340418.
    15. Wu X, Lippman SM. An intermittent approach for cancer chemoprevention. Nat Rev Cancer. 2011 11 10; 11(12):879-85. PMID: 22071977.
      View in: PubMed
    16. Wu X, Patterson S, Hawk E. Chemoprevention--history and general principles. Best Pract Res Clin Gastroenterol. 2011 Aug; 25(4-5):445-59. PMID: 22122762.
      View in: PubMed
    17. Huang S, Ren X, Wang L, Zhang L, Wu X. Lung-cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo. Cancer Prev Res (Phila). 2011 May; 4(5):666-73. PMID: 21543344.
      View in: PubMed
    18. Zhang L, Ren X, Alt E, Bai X, Huang S, Xu Z, Lynch PM, Moyer MP, Wen XF, Wu X. Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature. 2010 Apr 15; 464(7291):1058-61. PMID: 20348907; PMCID: PMC3425353.
    19. Ren X, Xu Z, Myers JN, Wu X. Bypass NFkappaB-mediated survival pathways by TRAIL and Smac. Cancer Biol Ther. 2007 Jul; 6(7):1031-5. PMID: 17611406.
      View in: PubMed
    20. Yang L, Deng YB, Wu XW. [Bcl-xl blocks tumor necrosis factor alpha-induced caspase 8 activation and apoptosis]. Zhonghua Gan Zang Bing Za Zhi. 2005 Apr; 13(4):286-9. PMID: 15850519.
      View in: PubMed
    21. Deng Y, Ren X, Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell. 2003 Oct 03; 115(1):61-70. PMID: 14532003.
      View in: PubMed
    22. Johnson MD, Wu X, Aithmitti N, Morrison RS. Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. J Biol Chem. 2002 Jun 21; 277(25):23000-7. PMID: 11943780.
      View in: PubMed
    23. Wu X, Deng Y. Bax and BH3-domain-only proteins in p53-mediated apoptosis. Front Biosci. 2002 Jan 01; 7:d151-6. PMID: 11779719.
      View in: PubMed
    24. Deng Y, Lin Y, Wu X. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev. 2002 Jan 01; 16(1):33-45. PMID: 11782443; PMCID: PMC155309.
    25. Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10863-8. PMID: 11517342; PMCID: PMC58565.
    26. Buschmann T, Lin Y, Aithmitti N, Fuchs SY, Lu H, Resnick-Silverman L, Manfredi JJ, Ronai Z, Wu X. Stabilization and activation of p53 by the coactivator protein TAFII31. J Biol Chem. 2001 Apr 27; 276(17):13852-7. PMID: 11278372.
      View in: PubMed
    27. Deng Y, Wu X. Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12050-5. PMID: 11050235; PMCID: PMC17292.
    28. Relaix F, Wei Xj, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X. Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5):2105-10. PMID: 10681424; PMCID: PMC15761.
    29. Fuchs SY, Adler V, Buschmann T, Wu X, Ronai Z. Mdm2 association with p53 targets its ubiquitination. Oncogene. 1998 Nov 12; 17(19):2543-7. PMID: 9824166.
      View in: PubMed
    30. Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, Ronai Z. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev. 1998 Sep 01; 12(17):2658-63. PMID: 9732264; PMCID: PMC317120.
    31. Relaix F, Wei XJ, Wu X, Sassoon DA. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. Nat Genet. 1998 Mar; 18(3):287-91. PMID: 9500555.
      View in: PubMed
    32. Chen J, Wu X, Lin J, Levine AJ. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol. 1996 May; 16(5):2445-52. PMID: 8628312; PMCID: PMC231233.
    33. Lin J, Reichner C, Wu X, Levine AJ. Analysis of wild-type and mutant p21WAF-1 gene activities. Mol Cell Biol. 1996 Apr; 16(4):1786-93. PMID: 8657154; PMCID: PMC231165.
    34. Wu X, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3602-6. PMID: 8170954; PMCID: PMC43628.
    35. Wu X, Wakamiya M, Vaishnav S, Geske R, Montgomery C, Jones P, Bradley A, Caskey CT. Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):742-6. PMID: 8290593; PMCID: PMC43025.
    36. Lin J, Wu X, Chen J, Chang A, Levine AJ. Functions of the p53 protein in growth regulation and tumor suppression. Cold Spring Harb Symp Quant Biol. 1994; 59:215-23. PMID: 7587073.
      View in: PubMed
    37. Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 1993 Jul; 7(7A):1126-32. PMID: 8319905.
      View in: PubMed
    38. Wu XW, Muzny DM, Lee CC, Caskey CT. Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol. 1992 Jan; 34(1):78-84. PMID: 1556746.
      View in: PubMed
    39. Wu XW, Lee CC, Muzny DM, Caskey CT. Urate oxidase: primary structure and evolutionary implications. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9412-6. PMID: 2594778; PMCID: PMC298506.
    40. Lee CC, Wu XW, Caskey CT. Cloning the full-length cDNA for the porcine urate oxidase by the MOPAC generated probe. Adv Exp Med Biol. 1989; 253A:499-505. PMID: 2624230.
      View in: PubMed
    41. Lee CC, Wu XW, Gibbs RA, Cook RG, Muzny DM, Caskey CT. Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase. Science. 1988 Mar 11; 239(4845):1288-91. PMID: 3344434.
      View in: PubMed
    42. Detection and enumeration of circulating tumor cells based on their invasive property. Oncotarget. 6:27304-27311.
    43. Plasmonic nanobubble theranostics for intra-operative and preventive treatment of head and neck squamous cell carcinoma.
    44. Low-dose 5-fluorouracil sensitizes HepG2 cells to TRAIL through TRAIL receptor DR5 and survivin-dependent mechanisms. Journal of Chemotherapy. 1-10.
    45. An advanced histologic method for evaluation of intestinal adenomas in mice using digital slides. PLoS One. 11.
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