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WILLIAM H KLEIN

TitleProfessor
InstitutionMD Anderson
DepartmentSystems Biology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA. Regulation of lifespan by neural excitation and REST. Nature. 2019 Oct; 574(7778):359-364. PMID: 31619788.
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    2. Persky S, Ferrer RA, Klein WMP, Goldring MR, Cohen RW, Kistler WD, Yaremych HE, Bouhlal S. Effects of Fruit and Vegetable Feeding Messages on Mothers and Fathers: Interactions Between Emotional State and Health Message Framing. Ann Behav Med. 2019 Aug 16; 53(9):789-800. PMID: 30395145.
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    3. Wiseman KP, Klein WMP. Evaluating Correlates of Awareness of the Association between Drinking Too Much Alcohol and Cancer Risk in the United States. Cancer Epidemiol Biomarkers Prev. 2019 Jul; 28(7):1195-1201. PMID: 31043419.
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    4. Kiyama T, Long Y, Chen CK, Whitaker CM, Shay A, Wu H, Badea TC, Mohsenin A, Parker-Thornburg J, Klein WH, Mills SL, Massey SC, Mao CA. Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019 Apr 16; 27(3):900-915.e5. PMID: 30995485.
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    5. Rice EL, Klein WMP. Interactions among perceived norms and attitudes about health-related behaviors in U.S. adolescents. Health Psychol. 2019 Mar; 38(3):268-275. PMID: 30762406.
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    6. Czajkowski SM, Riley WT, Stoney CM, Klein WMP, Croyle RT. Key milestones during 40 years of behavioral medicine at the National Institutes of Health. J Behav Med. 2019 Feb; 42(1):34-51. PMID: 30825087.
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    7. Turbitt E, Roberts MC, Taber JM, Waters EA, McNeel TS, Biesecker BB, Klein WMP. Genetic counseling, genetic testing, and risk perceptions for breast and colorectal cancer: Results from the 2015 National Health Interview Survey. Prev Med. 2019 Jun; 123:12-19. PMID: 30817954.
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    8. Klein WMP, McBride CM, Allen CG, Arredondo EM, Bloss CS, Kaphingst KA, Sturm AC, Wang C. Optimal Integration of Behavioral Medicine into Clinical Genetics and Genomics. Am J Hum Genet. 2019 02 07; 104(2):193-196. PMID: 30735659.
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    9. Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL. A novel crosslinking protocol stabilizes amyloid ß oligomers capable of inducing Alzheimer's-associated pathologies. J Neurochem. 2019 03; 148(6):822-836. PMID: 30565253.
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    10. Xie Z, Shapiro LP, Cahill ME, Russell TA, Lacor PN, Klein WL, Penzes P. Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers. Eur J Neurosci. 2019 May; 49(9):1091-1101. PMID: 30565792.
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    11. Turbitt E, Roberts MC, Hollister BM, Lewis KL, Biesecker LG, Klein WMP. Ethnic identity and engagement with genome sequencing research. Genet Med. 2019 08; 21(8):1735-1743. PMID: 30568309.
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    12. Chou WS, Oh A, Klein WMP. Addressing Health-Related Misinformation on Social Media. JAMA. 2018 Dec 18; 320(23):2417-2418. PMID: 30428002.
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    13. Ellis EM, Ferrer RA, Klein WMP. Factors beyond Lack of Knowledge That Predict "I Don't Know" Responses to Surveys That Assess HPV Knowledge. J Health Commun. 2018; 23(10-11):967-976. PMID: 30526402.
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    14. Silver MI, Klein W, Samimi G, Minasian L, Loud J, Roberts MC. Concordance with BRCA1/2 testing guidelines among women in The Health of Women (HOW) Study®. Breast Cancer Res Treat. 2019 Feb; 173(3):719-726. PMID: 30413980.
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    15. Lewis KL, Heidlebaugh AR, Epps S, Han PKJ, Fishler KP, Klein WMP, Miller IM, Ng D, Hepler C, Biesecker BB, Biesecker LG. Knowledge, motivations, expectations, and traits of an African, African-American, and Afro-Caribbean sequencing cohort and comparisons to the original ClinSeq® cohort. Genet Med. 2019 06; 21(6):1355-1362. PMID: 30382154.
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    16. Ellis EM, Klein WMP, Orehek E, Ferrer RA. Effects of Emotion on Medical Decisions Involving Tradeoffs. Med Decis Making. 2018 11; 38(8):1027-1039. PMID: 30343624.
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    17. Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA. Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 10 17; 13(1):56. PMID: 30333037.
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    18. Shapira R, Turbitt E, Erby LH, Biesecker BB, Klein WMP, Hooker GW. Adaptation of couples living with a high risk of breast/ovarian cancer and the association with risk-reducing surgery. Fam Cancer. 2018 10; 17(4):485-493. PMID: 29209897.
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    19. Dillard AJ, Ferrer RA, Bulthuis KRK, Klein WMP. Positive excessive drinker prototypes predict greater drinking and alcohol problems. Br J Health Psychol. 2018 11; 23(4):1000-1020. PMID: 30084206.
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    20. Roberts MC, Taber JM, Klein WM. Engagement with Genetic Information and Uptake of Genetic Testing: the Role of Trust and Personal Cancer History. J Cancer Educ. 2018 08; 33(4):893-900. PMID: 28105554.
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    21. Persky S, Kistler WD, Klein WMP, Ferrer RA. Internet Versus Virtual Reality Settings for Genomics Information Provision. Cyberpsychol Behav Soc Netw. 2019 Jan; 22(1):7-14. PMID: 29932735.
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    22. Hellwig LD, Biesecker BB, Lewis KL, Biesecker LG, James CA, Klein WMP. Ability of Patients to Distinguish Among Cardiac Genomic Variant Subclassifications. Circ Genom Precis Med. 2018 06; 11(6):e001975. PMID: 29848613.
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    23. Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra E Silva NM, Machado CM, Horta-Júnior JAC, Louzada PR, De Felice FG, Alves-Leon S, Marcondes J, Assirati JA, Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A. Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aß oligomers. J Neurosci Methods. 2018 09 01; 307:203-209. PMID: 29859877.
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    24. Reid AE, Taber JM, Ferrer RA, Biesecker BB, Lewis KL, Biesecker LG, Klein WMP. Associations of perceived norms with intentions to learn genomic sequencing results: Roles for attitudes and ambivalence. Health Psychol. 2018 06; 37(6):553-561. PMID: 29745680.
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    25. Klein WMP, Ferrer RA. On Being More Amenable to Threatening Risk Messages Concerning Close Others (vis-à-vis the Self). Pers Soc Psychol Bull. 2018 10; 44(10):1411-1423. PMID: 29716420.
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    26. Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease. J Pathol. 2018 05; 245(1):85-100. PMID: 29435980.
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    27. Roberts MC, Ferrer RA, Rendle KA, Kobrin SC, Taplin SH, Hesse BW, Klein WMP. Lay Beliefs About the Accuracy and Value of Cancer Screening. Am J Prev Med. 2018 May; 54(5):699-703. PMID: 29551327.
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    28. Kaufman AR, Dwyer LA, Land SR, Klein WMP, Park ER. Smoking-related health beliefs and smoking behavior in the National Lung Screening Trial. Addict Behav. 2018 09; 84:27-32. PMID: 29605757.
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    29. Ferrer RA, Klein WMP, Avishai A, Jones K, Villegas M, Sheeran P. When does risk perception predict protection motivation for health threats? A person-by-situation analysis. PLoS One. 2018; 13(3):e0191994. PMID: 29494705.
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    30. Turbitt E, Roberts MC, Ferrer RA, Taber JM, Lewis KL, Biesecker LG, Biesecker BB, Klein WM. Intentions to share exome sequencing results with family members: exploring spousal beliefs and attitudes. Eur J Hum Genet. 2018 05; 26(5):735-739. PMID: 29476166.
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    31. Ellis EM, Ferrer RA, Taber JM, Klein WMP. Relationship of "don't know" responses to cancer knowledge and belief questions with colorectal cancer screening behavior. Health Psychol. 2018 04; 37(4):394-398. PMID: 29389156.
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    32. Cline EN, Bicca MA, Viola KL, Klein WL. The Amyloid-ß Oligomer Hypothesis: Beginning of the Third Decade. J Alzheimers Dis. 2018; 64(s1):S567-S610. PMID: 29843241.
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    33. Ferrer RA, Lipkus IM, Cerully JL, McBride CM, Shepperd JA, Klein WMP. Developing a scale to assess health regulatory focus. Soc Sci Med. 2017 12; 195:50-60. PMID: 29144984.
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    34. Taber JM, Klein WMP, Persky S, Ferrer RA, Kaufman AR, Thai CL, Harris PR. Interest in and reactions to genetic risk information: The role of implicit theories and self-affirmation. Soc Sci Med. 2017 10; 190:101-110. PMID: 28858695.
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    35. Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aß oligomers. Mol Biol Cell. 2017 Oct 01; 28(20):2623-2636. PMID: 28963439.
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    36. Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL. A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-ß oligomers. J Neurochem. 2017 Sep; 142(6):934-947. PMID: 28670737.
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    37. Taber JM, Klein WMP, Lewis KL, Johnston JJ, Biesecker LG, Biesecker BB. Reactions to clinical reinterpretation of a gene variant by participants in a sequencing study. Genet Med. 2018 03; 20(3):337-345. PMID: 28771245.
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    38. Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathol. 2017 11; 134(5):769-788. PMID: 28612290.
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    39. Scheideler JK, Taber JM, Ferrer RA, Grenen EG, Klein WMP. Heart disease versus cancer: understanding perceptions of population prevalence and personal risk. J Behav Med. 2017 Oct; 40(5):839-845. PMID: 28577198.
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    40. Kiviniemi MT, Ellis EM, Hall MG, Moss JL, Lillie SE, Brewer NT, Klein WMP. Mediation, moderation, and context: Understanding complex relations among cognition, affect, and health behaviour. Psychol Health. 2018 01; 33(1):98-116. PMID: 28488897.
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    41. Cameron LD, Biesecker BB, Peters E, Taber JM, Klein WMP. Self-Regulation Principles Underlying Risk Perception and Decision Making within the Context of Genomic Testing. Soc Personal Psychol Compass. 2017 May; 11(5). PMID: 29225669.
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    42. Taber JM, Klein WM, Suls JM, Ferrer RA. Lay Awareness of the Relationship between Age and Cancer Risk. Ann Behav Med. 2017 Apr; 51(2):214-225. PMID: 27752991.
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    43. Fowler SL, Klein WMP, Ball L, McGuire J, Colditz GA, Waters EA. Using an Internet-Based Breast Cancer Risk Assessment Tool to Improve Social-Cognitive Precursors of Physical Activity. Med Decis Making. 2017 08; 37(6):657-669. PMID: 28363033.
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    44. Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD. Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development. 2017 05 01; 144(9):1698-1711. PMID: 28356311.
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    45. DiChiara T, DiNunno N, Clark J, Bu RL, Cline EN, Rollins MG, Gong Y, Brody DL, Sligar SG, Velasco PT, Viola KL, Klein WL. Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station. Yale J Biol Med. 2017 03; 90(1):45-61. PMID: 28356893.
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    46. Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG. Amyloid-ß oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons. J Biol Chem. 2017 05 05; 292(18):7395-7406. PMID: 28302722.
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    47. Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2018 03; 55(3):1977-1987. PMID: 28255908.
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    48. Klein WM, Grenen EG, O'Connell M, Blanch-Hartigan D, Chou WS, Hall KL, Taber JM, Vogel AL. Integrating knowledge across domains to advance the science of health behavior: overcoming challenges and facilitating success. Transl Behav Med. 2017 03; 7(1):98-105. PMID: 27520313.
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    49. Ferrer RA, Klein WM, Graff KA. Self-affirmation increases defensiveness toward health risk information among those experiencing negative emotions: Results from two national samples. Health Psychol. 2017 Apr; 36(4):380-391. PMID: 28206787.
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    50. Solomon I, Harrington E, Hooker G, Erby L, Axilbund J, Hampel H, Semotiuk K, Blanco A, Klein WMP, Giardiello F, Leonard L. Lynch Syndrome Limbo: Patient Understanding of Variants of Uncertain Significance. J Genet Couns. 2017 Aug; 26(4):866-877. PMID: 28127677.
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    51. Ferrer RA, Klein WM, Persoskie A, Avishai-Yitshak A, Sheeran P. The Tripartite Model of Risk Perception (TRIRISK): Distinguishing Deliberative, Affective, and Experiential Components of Perceived Risk. Ann Behav Med. 2016 10; 50(5):653-663. PMID: 26961206.
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    52. Kessels LT, Harris PR, Ruiter RA, Klein WM. Attentional effects of self-affirmation in response to graphic antismoking images. Health Psychol. 2016 Aug; 35(8):891-7. PMID: 27505212.
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    53. Savioz A, Giannakopoulos P, Herrmann FR, Klein WL, Kövari E, Bouras C, Giacobini E. A Study of Aß Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls. Neurodegener Dis. 2016; 16(5-6):398-406. PMID: 27400224.
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    54. Taber JM, Klein WM, Ferrer RA, Augustson E, Patrick H. A Pilot Test of Self-Affirmations to Promote Smoking Cessation in a National Smoking Cessation Text Messaging Program. JMIR Mhealth Uhealth. 2016 Jun 08; 4(2):e71. PMID: 27278108.
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    55. Persky S, Ferrer RA, Klein WM. Genomic Information may Inhibit Weight-Related Behavior Change Inclinations Among Individuals in a Fear State. Ann Behav Med. 2016 06; 50(3):452-9. PMID: 26850762.
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    56. Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW. Effective anti-Alzheimer Aß therapy involves depletion of specific Aß oligomer subtypes. Neurol Neuroimmunol Neuroinflamm. 2016 Jun; 3(3):e237. PMID: 27218118.
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    57. Emanuel AS, Howell JL, Taber JM, Ferrer RA, Klein WM, Harris PR. Spontaneous self-affirmation is associated with psychological well-being: Evidence from a US national adult survey sample. J Health Psychol. 2018 01; 23(1):95-102. PMID: 27160152.
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    58. Persky S, Ferrer RA, Klein WM. Nonverbal and paraverbal behavior in (simulated) medical visits related to genomics and weight: a role for emotion and race. J Behav Med. 2016 Oct; 39(5):804-14. PMID: 27146511.
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    59. Lauritzen I, Pardossi-Piquard R, Bourgeois A, Pagnotta S, Biferi MG, Barkats M, Lacor P, Klein W, Bauer C, Checler F. Intraneuronal aggregation of the ß-CTF fragment of APP (C99) induces Aß-independent lysosomal-autophagic pathology. Acta Neuropathol. 2016 08; 132(2):257-76. PMID: 27138984.
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    60. Taber JM, Klein WM, Ferrer RA, Kent EE, Harris PR. Optimism and Spontaneous Self-affirmation are Associated with Lower Likelihood of Cognitive Impairment and Greater Positive Affect among Cancer Survivors. Ann Behav Med. 2016 Apr; 50(2):198-209. PMID: 26497697.
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    61. Umeda T, Ono K, Sakai A, Yamashita M, Mizuguchi M, Klein WL, Yamada M, Mori H, Tomiyama T. Rifampicin is a candidate preventive medicine against amyloid-ß and tau oligomers. Brain. 2016 05; 139(Pt 5):1568-86. PMID: 27020329.
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    62. Mao CA, Agca C, Mocko-Strand JA, Wang J, Ullrich-Lüter E, Pan P, Wang SW, Arnone MI, Frishman LJ, Klein WH. Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proc Biol Sci. 2016 Mar 16; 283(1826):20152978. PMID: 26962139.
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    63. Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathol Commun. 2016 Feb 25; 4:16. PMID: 26916443.
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    64. Dutcher JM, Creswell JD, Pacilio LE, Harris PR, Klein WM, Levine JM, Bower JE, Muscatell KA, Eisenberger NI. Self-Affirmation Activates the Ventral Striatum: A Possible Reward-Related Mechanism for Self-Affirmation. Psychol Sci. 2016 Apr; 27(4):455-66. PMID: 26917214.
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    65. Beekman JB, Ferrer RA, Klein WM, Persky S. Effects of perceived weight discrimination on willingness to adopt unhealthy behaviours: influence of genomic information. Psychol Health. 2016; 31(3):334-48. PMID: 26406164.
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    66. Ferrer R, Klein WM. Risk perceptions and health behavior. Curr Opin Psychol. 2015 Oct 01; 5:85-89. PMID: 26258160.
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    67. Taber JM, Howell JL, Emanuel AS, Klein WM, Ferrer RA, Harris PR. Associations of spontaneous self-affirmation with health care experiences and health information seeking in a national survey of US adults. Psychol Health. 2016; 31(3):292-309. PMID: 26315683.
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    68. Taber JM, Klein WM, Ferrer RA, Lewis KL, Harris PR, Shepperd JA, Biesecker LG. Information Avoidance Tendencies, Threat Management Resources, and Interest in Genetic Sequencing Feedback. Ann Behav Med. 2015 Aug; 49(4):616-21. PMID: 25582989.
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    69. Persoskie A, Ferrer RA, Taber JM, Klein WM, Parascandola M, Harris PR. Smoke-free air laws and quit attempts: Evidence for a moderating role of spontaneous self-affirmation. Soc Sci Med. 2015 Sep; 141:46-55. PMID: 26246033.
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    70. Lewis KL, Han PK, Hooker GW, Klein WM, Biesecker LG, Biesecker BB. Characterizing Participants in the ClinSeq Genome Sequencing Cohort as Early Adopters of a New Health Technology. PLoS One. 2015; 10(7):e0132690. PMID: 26186621.
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    71. Kaufman AR, Suls JM, Klein WM. Communicating tobacco product harm: Compared to what? Addict Behav. 2016 Jan; 52:123-5. PMID: 26162963.
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    72. Taber JM, Klein WM, Ferrer RA, Han PK, Lewis KL, Biesecker LG, Biesecker BB. Perceived ambiguity as a barrier to intentions to learn genome sequencing results. J Behav Med. 2015 Oct; 38(5):715-26. PMID: 26003053.
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    73. Kaufman AR, Koblitz AR, Persoskie A, Ferrer RA, Klein WM, Dwyer LA, Park ER. Factor Structure and Stability of Smoking-Related Health Beliefs in the National Lung Screening Trial. Nicotine Tob Res. 2016 Mar; 18(3):321-9. PMID: 25964503.
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    74. Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S. Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun. 2015 May 08; 6:7089. PMID: 25953241.
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    75. Wilcox KC, Marunde MR, Das A, Velasco PT, Kuhns BD, Marty MT, Jiang H, Luan CH, Sligar SG, Klein WL. Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aß Oligomers. PLoS One. 2015; 10(4):e0125263. PMID: 25928376.
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    76. Klein WM, Hamilton JG, Harris PR, Han PK. Health messaging to individuals who perceive ambiguity in health communications: the promise of self-affirmation. J Health Commun. 2015; 20(5):566-72. PMID: 25806652.
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    77. Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C. Neuronal amyloid-ß accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease. Brain. 2015 Jun; 138(Pt 6):1722-37. PMID: 25732182.
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    78. Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG. Alzheimer-associated Aß oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015 Feb; 7(2):190-210. PMID: 25617315.
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    79. Viola KL, Klein WL. Amyloid ß oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathol. 2015 Feb; 129(2):183-206. PMID: 25604547.
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    80. Viola KL, Sbarboro J, Sureka R, De M, Bicca MA, Wang J, Vasavada S, Satpathy S, Wu S, Joshi H, Velasco PT, MacRenaris K, Waters EA, Lu C, Phan J, Lacor P, Prasad P, Dravid VP, Klein WL. Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease. Nat Nanotechnol. 2015 Jan; 10(1):91-8. PMID: 25531084.
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    81. Ferrer RA, Taber JM, Klein WM, Harris PR, Lewis KL, Biesecker LG. The role of current affect, anticipated affect and spontaneous self-affirmation in decisions to receive self-threatening genetic risk information. Cogn Emot. 2015; 29(8):1456-65. PMID: 25482843.
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    82. Sebollela A, Mustata GM, Luo K, Velasco PT, Viola KL, Cline EN, Shekhawat GS, Wilcox KC, Dravid VP, Klein WL. Elucidating molecular mass and shape of a neurotoxic Aß oligomer. ACS Chem Neurosci. 2014 Dec 17; 5(12):1238-45. PMID: 25343357.
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    83. Taber JM, Klein WM, Ferrer RA, Lewis KL, Biesecker LG, Biesecker BB. Dispositional optimism and perceived risk interact to predict intentions to learn genome sequencing results. Health Psychol. 2015 Jul; 34(7):718-28. PMID: 25313897.
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    84. Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Alzheimer's disease-like pathology induced by amyloid-ß oligomers in nonhuman primates. J Neurosci. 2014 Oct 08; 34(41):13629-43. PMID: 25297091.
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    85. Han PK, Williams AE, Haskins A, Gutheil C, Lucas FL, Klein WM, Mazor KM. Individual differences in aversion to ambiguity regarding medical tests and treatments: association with cancer screening cognitions. Cancer Epidemiol Biomarkers Prev. 2014 Dec; 23(12):2916-23. PMID: 25258015.
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    86. Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, Hardy P, Bhosle V, Varma DR, Gobeil F, Beauséjour C, Boileau C, Klein W, Hollenberg M, Ribeiro-da-Silva A, Andelfinger G, Chemtob S. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med. 2014 Oct; 20(10):1165-73. PMID: 25216639.
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    87. Klein WM, Shepperd JA, Suls J, Rothman AJ, Croyle RT. Realizing the promise of social psychology in improving public health. Pers Soc Psychol Rev. 2015 Feb; 19(1):77-92. PMID: 24981514.
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    88. Heffern MC, Velasco PT, Matosziuk LM, Coomes JL, Karras C, Ratner MA, Klein WL, Eckermann AL, Meade TJ. Modulation of amyloid-ß aggregation by histidine-coordinating Cobalt(III) Schiff base complexes. Chembiochem. 2014 Jul 21; 15(11):1584-9. PMID: 24961930.
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    89. Iulita MF, Allard S, Richter L, Munter LM, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G, Cuello AC. Intracellular Aß pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study. Acta Neuropathol Commun. 2014 Jun 05; 2:61. PMID: 24903713.
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    90. Biesecker BB, Klein W, Lewis KL, Fisher TC, Wright MF, Biesecker LG, Han PK. How do research participants perceive "uncertainty" in genome sequencing? Genet Med. 2014 Dec; 16(12):977-80. PMID: 24875302.
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    91. Gao Z, Mao CA, Pan P, Mu X, Klein WH. Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation. Dev Neurobiol. 2014 Nov; 74(11):1123-40. PMID: 24799426.
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    92. Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-ß is common in normal brain. Curr Alzheimer Res. 2014 May; 11(4):317-24. PMID: 24597504.
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    93. Klein WM, Ferrer RA, Graff KA, Kaufman AR, Han PK. Perceived ambiguity, fatalism, and believing cancer is more prevalent than heart disease. Am J Prev Med. 2014 Apr; 46(4):e45-7. PMID: 24650848.
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    94. Persoskie A, Ferrer RA, Nelson WL, Klein WM. Precancer risk perceptions predict postcancer subjective well-being. Health Psychol. 2014 Sep; 33(9):1023-32. PMID: 24588629.
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    95. Klein WM, Bloch M, Hesse BW, McDonald PG, Nebeling L, O'Connell ME, Riley WT, Taplin SH, Tesauro G. Behavioral research in cancer prevention and control: a look to the future. Am J Prev Med. 2014 Mar; 46(3):303-11. PMID: 24512871.
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    96. Tesauro GM, Seger YR, Dijoseph L, Schnell JD, Klein WM. Assessing the value of a Small Grants Program for behavioral research in cancer control. Transl Behav Med. 2014 Mar; 4(1):79-85. PMID: 24653778.
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    97. Harris PR, Brearley I, Sheeran P, Barker M, Klein WM, Creswell JD, Levine JM, Bond R. Combining self-affirmation with implementation intentions to promote fruit and vegetable consumption. Health Psychol. 2014 Jul; 33(7):729-36. PMID: 24490648.
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    98. Portnoy DB, Kaufman AR, Klein WM, Doyle TA, de Groot M. Cognitive and Affective Perceptions of Vulnerability as Predictors of Exercise Intentions among People with Type 2 Diabetes. J Risk Res. 2014 Jan 01; 17(2):177-193. PMID: 24563609.
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    99. Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. TNF-a mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's ß-amyloid oligomers in mice and monkeys. Cell Metab. 2013 Dec 03; 18(6):831-43. PMID: 24315369.
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    100. Hamilton JG, Birmingham WC, Tehranifar P, Irwin ML, Klein WM, Nebeling L, Chubak J. Transitioning to independence and maintaining research careers in a new funding climate: american society of preventive oncology junior members interest group report. Cancer Epidemiol Biomarkers Prev. 2013 Nov; 22(11):2138-42. PMID: 24190867.
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    101. Napper LE, Harris PR, Klein WM. Combining self-affirmation with the extended parallel process model: the consequences for motivation to eat more fruit and vegetables. Health Commun. 2014; 29(6):610-8. PMID: 24138335.
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    102. Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):E4026-35. PMID: 24082127.
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    103. Persoskie A, Ferrer RA, Klein WM. Association of cancer worry and perceived risk with doctor avoidance: an analysis of information avoidance in a nationally representative US sample. J Behav Med. 2014 Oct; 37(5):977-87. PMID: 24072430.
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    104. Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, Jung YK. Fc?RIIb mediates amyloid-ß neurotoxicity and memory impairment in Alzheimer's disease. J Clin Invest. 2013 Jul; 123(7):2791-802. PMID: 23921129.
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    105. Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST. Memantine rescues transient cognitive impairment caused by high-molecular-weight aß oligomers but not the persistent impairment induced by low-molecular-weight oligomers. J Neurosci. 2013 Jun 05; 33(23):9626-34. PMID: 23739959.
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    106. Portnoy DB, Ferrer RA, Bergman HE, Klein WM. Changing deliberative and affective responses to health risk: a meta-analysis. Health Psychol Rev. 2014; 8(3):296-318. PMID: 25053216.
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    107. Klein WM, Rothman AJ, Cameron LD. Theoretical innovations in social and personality psychology and implications for health: introduction to special issue. Health Psychol. 2013 May; 32(5):457-9. PMID: 23646830.
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    108. Creswell JD, Dutcher JM, Klein WM, Harris PR, Levine JM. Self-affirmation improves problem-solving under stress. PLoS One. 2013; 8(5):e62593. PMID: 23658751.
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    109. Nowotschin S, Costello I, Piliszek A, Kwon GS, Mao CA, Klein WH, Robertson EJ, Hadjantonakis AK. The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes Dev. 2013 May 01; 27(9):997-1002. PMID: 23651855.
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    110. Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM. Disruption of neocortical histone H3 homeostasis by soluble Aß: implications for Alzheimer's disease. Neurobiol Aging. 2013 Sep; 34(9):2081-90. PMID: 23582659.
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    111. Wang J, Sun Z, Zhang Z, Saadi I, Wang J, Li X, Gao S, Engle JJ, Kuburas A, Fu X, Yu W, Klein WH, Russo AF, Amendt BA. Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity. J Biol Chem. 2013 May 03; 288(18):12580-95. PMID: 23515314.
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    112. Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aß and differential drug responsiveness. Cell Stem Cell. 2013 Apr 04; 12(4):487-96. PMID: 23434393.
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    113. Marty MT, Wilcox KC, Klein WL, Sligar SG. Nanodisc-solubilized membrane protein library reflects the membrane proteome. Anal Bioanal Chem. 2013 May; 405(12):4009-16. PMID: 23400332.
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    114. Mao CA, Cho JH, Wang J, Gao Z, Pan P, Tsai WW, Frishman LJ, Klein WH. Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7. Development. 2013 Feb 01; 140(3):541-51. PMID: 23293286.
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    115. Xiao C, Davis FJ, Chauhan BC, Viola KL, Lacor PN, Velasco PT, Klein WL, Chauhan NB. Brain transit and ameliorative effects of intranasally delivered anti-amyloid-ß oligomer antibody in 5XFAD mice. J Alzheimers Dis. 2013; 35(4):777-88. PMID: 23542865.
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    116. Klein WL. Synaptotoxic amyloid-ß oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease? J Alzheimers Dis. 2013; 33 Suppl 1:S49-65. PMID: 22785404.
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    117. Ferrer RA, Portnoy DB, Klein WM. Worry and risk perceptions as independent and interacting predictors of health protective behaviors. J Health Commun. 2013; 18(4):397-409. PMID: 23272708.
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    118. Cho JH, Mao CA, Klein WH. Adult mice transplanted with embryonic retinal progenitor cells: new approach for repairing damaged optic nerves. Mol Vis. 2012; 18:2658-72. PMID: 23170059.
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    119. Mandal NA, Tran JT, Saadi A, Rahman AK, Huynh TP, Klein WH, Cho JH. Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene. Exp Eye Res. 2013 Jan; 106:24-33. PMID: 23142158.
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    120. Velasco PT, Heffern MC, Sebollela A, Popova IA, Lacor PN, Lee KB, Sun X, Tiano BN, Viola KL, Eckermann AL, Meade TJ, Klein WL. Synapse-binding subpopulations of Aß oligomers sensitive to peptide assembly blockers and scFv antibodies. ACS Chem Neurosci. 2012 Nov 21; 3(11):972-81. PMID: 23173076.
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    121. Pitt J, Thorner M, Brautigan D, Larner J, Klein WL. Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aß oligomers by insulin mimetic chiro-inositols. FASEB J. 2013 Jan; 27(1):199-207. PMID: 23073831.
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    122. Costa RO, Lacor PN, Ferreira IL, Resende R, Auberson YP, Klein WL, Oliveira CR, Rego AC, Pereira CM. Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers. Aging Cell. 2012 Oct; 11(5):823-33. PMID: 22708890.
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    123. Mizuguchi R, Naritsuka H, Mori K, Mao CA, Klein WH, Yoshihara Y. Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb. J Neurosci. 2012 Jun 27; 32(26):8831-44. PMID: 22745484.
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    124. Klein WM. Conducting multilevel intervention research: leveraging and looking beyond methodological advances. J Natl Cancer Inst Monogr. 2012 May; 2012(44):78-9. PMID: 22623599.
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    125. Shavers VL, Fagan P, Jones D, Klein WM, Boyington J, Moten C, Rorie E. The state of research on racial/ethnic discrimination in the receipt of health care. Am J Public Health. 2012 May; 102(5):953-66. PMID: 22494002.
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    126. Ferrer RA, Bergman HE, Klein WM. Worry as a predictor of nutrition behaviors: results from a nationally representative survey. Health Educ Behav. 2013 Feb; 40(1):88-96. PMID: 22505569.
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    127. Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Klein WL, Ferreira ST, de Mello FG. Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-ß peptide oligomers. J Biol Chem. 2012 Jun 01; 287(23):19377-85. PMID: 22505713.
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    128. Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aß oligomers. J Clin Invest. 2012 Apr; 122(4):1339-53. PMID: 22476196.
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    129. Zhou Y, Klein WL. Aß oligomers-induced toxicity is attenuated in cells cultured with NbActiv4™ medium. Neurotox Res. 2012 Nov; 22(4):335-44. PMID: 22441766.
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    130. Ferrer RA, Klein WM, Zajac LE, Sutton-Tyrrell K, Muldoon MF, Kamarck TW. Unrealistic optimism is associated with subclinical atherosclerosis. Health Psychol. 2012 Nov; 31(6):815-20. PMID: 22429124.
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    131. Zou M, Li S, Klein WH, Xiang M. Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012 Apr 15; 364(2):114-27. PMID: 22326227.
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    132. Umeda T, Tomiyama T, Kitajima E, Idomoto T, Nomura S, Lambert MP, Klein WL, Mori H. Hypercholesterolemia accelerates intraneuronal accumulation of Aß oligomers resulting in memory impairment in Alzheimer's disease model mice. Life Sci. 2012 Dec 10; 91(23-24):1169-76. PMID: 22273754.
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    133. Soura V, Stewart-Parker M, Williams TL, Ratnayaka A, Atherton J, Gorringe K, Tuffin J, Darwent E, Rambaran R, Klein W, Lacor P, Staras K, Thorpe J, Serpell LC. Visualization of co-localization in Aß42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. Biochem J. 2012 Jan 15; 441(2):579-90. PMID: 21955321.
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    134. Bitel CL, Kasinathan C, Kaswala RH, Klein WL, Frederikse PH. Amyloid-ß and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model. J Alzheimers Dis. 2012; 32(2):291-305. PMID: 22785400.
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    135. Ferrer RA, Dillard AJ, Klein WM. Projection, conformity and deviance regulation: a prospective study of alcohol use. Psychol Health. 2012; 27(6):688-703. PMID: 22172018.
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    136. Agca C, Elhajj MC, Klein WH, Venuti JM. Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus. J Comp Neurol. 2011 Dec 01; 519(17):3566-79. PMID: 21800307.
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    137. Han PK, Klein WM, Arora NK. Varieties of uncertainty in health care: a conceptual taxonomy. Med Decis Making. 2011 Nov-Dec; 31(6):828-38. PMID: 22067431.
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    138. Ferreira ST, Klein WL. The Aß oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiol Learn Mem. 2011 Nov; 96(4):529-43. PMID: 21914486.
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    139. Ferrer RA, Hall KL, Portnoy DB, Ling BS, Han PK, Klein WM. Relationships among health perceptions vary depending on stage of readiness for colorectal cancer screening. Health Psychol. 2011 Sep; 30(5):525-35. PMID: 21534672.
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    140. Ferrer RA, Klein WM, Zajac LE, Land SR, Ling BS. An affective booster moderates the effect of gain- and loss-framed messages on behavioral intentions for colorectal cancer screening. J Behav Med. 2012 Aug; 35(4):452-61. PMID: 21850516.
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    141. Portnoy DB, Han PK, Ferrer RA, Klein WM, Clauser SB. Physicians' attitudes about communicating and managing scientific uncertainty differ by perceived ambiguity aversion of their patients. Health Expect. 2013 Dec; 16(4):362-72. PMID: 21838835.
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    142. Bao F, Wicklund L, Lacor PN, Klein WL, Nordberg A, Marutle A. Different ß-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity. Neurobiol Aging. 2012 Apr; 33(4):825.e1-13. PMID: 21683475.
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    143. Wilcox KC, Lacor PN, Pitt J, Klein WL. Aß oligomer-induced synapse degeneration in Alzheimer's disease. Cell Mol Neurobiol. 2011 Aug; 31(6):939-48. PMID: 21538118.
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    144. Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert MP, Klein WL, Mori H. Intraneuronal amyloid ß oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo. J Neurosci Res. 2011 Jul; 89(7):1031-42. PMID: 21488093.
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    145. Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello AC. Intracellular Aß-oligomers and early inflammation in a model of Alzheimer's disease. Neurobiol Aging. 2012 Jul; 33(7):1329-42. PMID: 21414686.
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    146. Han PK, Klein WM, Killam B, Lehman T, Massett H, Freedman AN. Representing randomness in the communication of individualized cancer risk estimates: effects on cancer risk perceptions, worry, and subjective uncertainty about risk. Patient Educ Couns. 2012 Jan; 86(1):106-13. PMID: 21377311.
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    147. Bergman HE, Reeve BB, Moser RP, Scholl S, Klein WM. Development of a Comprehensive Heart Disease Knowledge Questionnaire. Am J Health Educ. 2011 Mar; 42(2):74-87. PMID: 21720571.
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    148. Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC. Transgenic mice as a model of pre-clinical Alzheimer's disease. Curr Alzheimer Res. 2011 Feb; 8(1):4-23. PMID: 21143159.
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    149. Meadows E, Flynn JM, Klein WH. Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice. PLoS One. 2011 Jan 14; 6(1):e16184. PMID: 21264243.
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    150. Saraiva LM, Seixas da Silva GS, Galina A, da-Silva WS, Klein WL, Ferreira ST, De Felice FG. Amyloid-ß triggers the release of neuronal hexokinase 1 from mitochondria. PLoS One. 2010 Dec 16; 5(12):e15230. PMID: 21179577.
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    151. Klein WM, Lipkus IM, Scholl SM, McQueen A, Cerully JL, Harris PR. Self-affirmation moderates effects of unrealistic optimism and pessimism on reactions to tailored risk feedback. Psychol Health. 2010 Dec; 25(10):1195-208. PMID: 20204982.
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    152. Waters EA, Klein WM, Moser RP, Yu M, Waldron WR, McNeel TS, Freedman AN. Correlates of unrealistic risk beliefs in a nationally representative sample. J Behav Med. 2011 Jun; 34(3):225-35. PMID: 21110077.
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    153. Decker H, Jürgensen S, Adrover MF, Brito-Moreira J, Bomfim TR, Klein WL, Epstein AL, De Felice FG, Jerusalinsky D, Ferreira ST. N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-ß peptide oligomers. J Neurochem. 2010 Dec; 115(6):1520-9. PMID: 20950339.
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    154. Flynn JM, Meadows E, Fiorotto M, Klein WH. Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse. PLoS One. 2010 Oct 22; 5(10):e13535. PMID: 21042574.
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    155. Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol. 2011 Jan 01; 349(1):90-9. PMID: 20969844.
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    156. Kiyama T, Mao CA, Cho JH, Fu X, Pan P, Mu X, Klein WH. Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate. Vision Res. 2011 Jan 28; 51(2):251-9. PMID: 20951721.
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    157. Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally J, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell. 2010 Oct 01; 143(1):35-45. PMID: 20887891.
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    158. Sessa A, Mao CA, Colasante G, Nini A, Klein WH, Broccoli V. Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons. Genes Dev. 2010 Aug 15; 24(16):1816-26. PMID: 20713522.
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    159. Nogalska A, D'Agostino C, Engel WK, Klein WL, Askanas V. Novel demonstration of amyloid-ß oligomers in sporadic inclusion-body myositis muscle fibers. Acta Neuropathol. 2010 Nov; 120(5):661-6. PMID: 20711838.
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    160. Han PK, Klein WM, Lehman T, Killam B, Massett H, Freedman AN. Communication of uncertainty regarding individualized cancer risk estimates: effects and influential factors. Med Decis Making. 2011 Mar-Apr; 31(2):354-66. PMID: 20671211.
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    161. Krafft GA, Klein WL. ADDLs and the signaling web that leads to Alzheimer's disease. Neuropharmacology. 2010 Sep-Oct; 59(4-5):230-42. PMID: 20650286.
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    162. Renner M, Lacor PN, Velasco PT, Xu J, Contractor A, Klein WL, Triller A. Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5. Neuron. 2010 Jun 10; 66(5):739-54. PMID: 20547131.
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    163. Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci. 2010 Apr 07; 30(14):4845-56. PMID: 20371804.
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    164. Waters EA, Arora NK, Klein WM, Han PK. Perceived risk, trust and health-related quality of life among cancer survivors. Ann Behav Med. 2010 Feb; 39(1):91-7. PMID: 20333563.
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    165. Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC. A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. J Alzheimers Dis. 2010; 20(1):113-26. PMID: 20164597.
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    166. Han PK, Moser RP, Klein WM, Beckjord EB, Dunlavy AC, Hesse BW. Predictors of perceived ambiguity about cancer prevention recommendations: sociodemographic factors and mass media exposures. Health Commun. 2009 Dec; 24(8):764-72. PMID: 20183385.
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    167. Shekhawat GS, Lambert MP, Sharma S, Velasco PT, Viola KL, Klein WL, Dravid VP. Soluble state high resolution atomic force microscopy study of Alzheimer's beta-amyloid oligomers. Appl Phys Lett. 2009 Nov 02; 95(18):183701. PMID: 19997583.
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    168. Klein WM, Harris PR. Self-affirmation enhances attentional bias toward threatening components of a persuasive message. Psychol Sci. 2009 Dec; 20(12):1463-7. PMID: 19883488.
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    169. Han PK, Reeve BB, Moser RP, Klein WM. Aversion to ambiguity regarding medical tests and treatments: measurement, prevalence, and relationship to sociodemographic factors. J Health Commun. 2009 Sep; 14(6):556-72. PMID: 19731127.
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    170. Fu X, Kiyama T, Li R, Russell M, Klein WH, Mu X. Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse. Dev Dyn. 2009 Sep; 238(9):2309-17. PMID: 19459208.
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    171. Dillard AJ, Midboe AM, Klein WM. The dark side of optimism: unrealistic optimism about problems with alcohol predicts subsequent negative event experiences. Pers Soc Psychol Bull. 2009 Nov; 35(11):1540-50. PMID: 19721102.
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    172. Pitt J, Roth W, Lacor P, Smith AB, Blankenship M, Velasco P, De Felice F, Breslin P, Klein WL. Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol. 2009 Oct 15; 240(2):189-97. PMID: 19631677.
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    173. Peng S, Garzon DJ, Marchese M, Klein W, Ginsberg SD, Francis BM, Mount HT, Mufson EJ, Salehi A, Fahnestock M. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci. 2009 Jul 22; 29(29):9321-9. PMID: 19625522.
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    174. Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. PLoS One. 2009 Jul 10; 4(7):e6197. PMID: 19593388.
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    175. Kiyama T, Zhang J, Liang S, Liang S, Klein WH. Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus. Mar Genomics. 2009 Jun; 2(2):85-98. PMID: 21798176.
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    176. Agca C, Klein WH, Venuti JM. Reduced O2 and elevated ROS in sea urchin embryos leads to defects in ectoderm differentiation. Dev Dyn. 2009 Jul; 238(7):1777-87. PMID: 19517573.
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    177. Han PK, Klein WM, Lehman TC, Massett H, Lee SC, Freedman AN. Laypersons' responses to the communication of uncertainty regarding cancer risk estimates. Med Decis Making. 2009 May-Jun; 29(3):391-403. PMID: 19470720.
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    178. Zhao WQ, Lacor PN, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. J Biol Chem. 2009 Jul 10; 284(28):18742-53. PMID: 19406747.
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    179. Anker JN, Hall WP, Lambert MP, Velasco PT, Mrksich M, Klein WL, Van Duyne RP. Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry. J Phys Chem C Nanomater Interfaces. 2009 Mar 24; 113(15):5891-5894. PMID: 20161175.
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    180. Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Mol Ther. 2009 May; 17(5):803-9. PMID: 19277012.
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    181. Han PK, Lehman TC, Massett H, Lee SJ, Klein WM, Freedman AN. Conceptual problems in laypersons' understanding of individualized cancer risk: a qualitative study. Health Expect. 2009 Mar; 12(1):4-17. PMID: 19250148.
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    182. Lambert MP, Velasco PT, Viola KL, Klein WL. Targeting generation of antibodies specific to conformational epitopes of amyloid beta-derived neurotoxins. CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):65-81. PMID: 19275637.
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    183. De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1971-6. PMID: 19188609.
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    184. Agca C, Klein WH, Venuti JM. Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment. Mech Dev. 2009 May-Jun; 126(5-6):430-42. PMID: 19368800.
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    185. Nishitsuji K, Tomiyama T, Ishibashi K, Ito K, Teraoka R, Lambert MP, Klein WL, Mori H. The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. Am J Pathol. 2009 Mar; 174(3):957-69. PMID: 19164507.
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    186. Wang XP, Zhang JH, Wang YJ, Feng Y, Zhang X, Sun XX, Li JL, Du XT, Lambert MP, Yang SG, Zhao M, Klein WL, Liu RT. Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers. FEBS Lett. 2009 Feb 04; 583(3):579-84. PMID: 19162022.
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    187. Tchantchou F, Lacor PN, Cao Z, Lao L, Hou Y, Cui C, Klein WL, Luo Y. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. J Alzheimers Dis. 2009; 18(4):787-98. PMID: 19661619.
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    188. Tang H, Macpherson P, Marvin M, Meadows E, Klein WH, Yang XJ, Goldman D. A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Mol Biol Cell. 2009 Feb; 20(4):1120-31. PMID: 19109424.
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    189. Cho JH, Mu X, Wang SW, Klein WH. Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice. Exp Eye Res. 2009 Mar; 88(3):542-52. PMID: 19109949.
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    190. Sessa A, Mao CA, Hadjantonakis AK, Klein WH, Broccoli V. Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron. 2008 Oct 09; 60(1):56-69. PMID: 18940588.
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    191. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med. 2008 Oct; 14(10):1067-76. PMID: 18836459.
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    192. Mao CA, Wang SW, Pan P, Klein WH. Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Development. 2008 Oct; 135(20):3379-88. PMID: 18787067.
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    193. Wu Y, Cao Z, Klein WL, Luo Y. Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers. Neurobiol Aging. 2010 Jun; 31(6):1055-8. PMID: 18762355.
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    194. Meadows E, Cho JH, Flynn JM, Klein WH. Myogenin regulates a distinct genetic program in adult muscle stem cells. Dev Biol. 2008 Oct 15; 322(2):406-14. PMID: 18721801.
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    195. Gramling R, Klein W, Roberts M, Waring ME, Gramling D, Eaton CB. Self-rated cardiovascular risk and 15-year cardiovascular mortality. Ann Fam Med. 2008 Jul-Aug; 6(4):302-6. PMID: 18626029.
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    196. Mu X, Fu X, Beremand PD, Thomas TL, Klein WH. Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6942-7. PMID: 18460603.
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    197. Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res. 2008 Jun 24; 1216:92-103. PMID: 18486110.
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    198. McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 May 01; 1207:225-36. PMID: 18374906.
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    199. Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development. 2008 Jan; 135(2):271-80. PMID: 18077589.
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    200. Han PK, Moser RP, Klein WM. Perceived ambiguity about cancer prevention recommendations: associations with cancer-related perceptions and behaviours in a US population survey. Health Expect. 2007 Dec; 10(4):321-36. PMID: 17986069.
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    201. Klein W, Geaghan T, Macdonald T. Unplanned sexual activity as a consequence of alcohol use: a prospective study of risk perceptions and alcohol use among college freshmen. J Am Coll Health. 2007 Nov-Dec; 56(3):317-23. PMID: 18089515.
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    202. Durairajan SS, Yuan Q, Xie L, Chan WS, Kum WF, Koo I, Liu C, Song Y, Huang JD, Klein WL, Li M. Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. Neurochem Int. 2008 Mar-Apr; 52(4-5):741-50. PMID: 17964692.
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    203. Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J. 2008 Jan; 22(1):246-60. PMID: 17720802.
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    204. Kiyama T, Klein WH. SpGataE, a Strongylocentrotus purpuratus ortholog of mammalian Gata4/5/6: protein expression, interaction with putative target gene spec2a, and identification of friend of Gata factor SpFog1. Dev Genes Evol. 2007 Sep; 217(9):651-63. PMID: 17710433.
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    205. Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR, Klein WH. Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Dev Biol. 2007 Nov 15; 311(2):650-64. PMID: 17904117.
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    206. Rishniw M, Fisher PW, Doran RM, Meadows E, Klein WH, Kotlikoff MI. Smooth muscle persists in the muscularis externa of developing and adult mouse esophagus. J Muscle Res Cell Motil. 2007; 28(2-3):153-65. PMID: 17638088.
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    207. De Felice FG, Wasilewska-Sampaio AP, Barbosa AC, Gomes FC, Klein WL, Ferreira ST. Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease. Curr Alzheimer Res. 2007 Jul; 4(3):263-71. PMID: 17627483.
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    208. Cho JH, Klein WH, Tsai MJ. Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina. Mech Dev. 2007 Aug; 124(7-8):543-50. PMID: 17629466.
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    209. Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF. Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9319-24. PMID: 17519332.
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    210. De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiol Aging. 2008 Sep; 29(9):1334-47. PMID: 17403556.
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    211. Han PK, Kobrin SC, Klein WM, Davis WW, Stefanek M, Taplin SH. Perceived ambiguity about screening mammography recommendations: association with future mammography uptake and perceptions. Cancer Epidemiol Biomarkers Prev. 2007 Mar; 16(3):458-66. PMID: 17372241.
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    212. De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL. Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem. 2007 Apr 13; 282(15):11590-601. PMID: 17308309.
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    213. Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci. 2007 Jan 24; 27(4):796-807. PMID: 17251419.
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    214. Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci. 2006 Dec 13; 26(50):13102-13. PMID: 17167099.
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    215. Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem. 2007 Jan; 100(1):23-35. PMID: 17116235.
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    216. Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R. The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006 Nov 10; 314(5801):941-52. PMID: 17095691.
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    217. Burke RD, Angerer LM, Elphick MR, Humphrey GW, Yaguchi S, Kiyama T, Liang S, Mu X, Agca C, Klein WH, Brandhorst BP, Rowe M, Wilson K, Churcher AM, Taylor JS, Chen N, Murray G, Wang D, Mellott D, Olinski R, Hallböök F, Thorndyke MC. A genomic view of the sea urchin nervous system. Dev Biol. 2006 Dec 01; 300(1):434-60. PMID: 16965768.
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    218. Fu X, Sun H, Klein WH, Mu X. Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development. Dev Biol. 2006 Nov 15; 299(2):424-37. PMID: 16959241.
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    219. Boutaud O, Montine TJ, Chang L, Klein WL, Oates JA. PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J Neurochem. 2006 Feb; 96(4):917-23. PMID: 16412101.
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    220. Knapp JR, Davie JK, Myer A, Meadows E, Olson EN, Klein WH. Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size. Development. 2006 Feb; 133(4):601-10. PMID: 16407395.
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    221. Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. Eur J Neurosci. 2006 Jan; 23(1):251-60. PMID: 16420434.
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    222. Klein WL. Synaptic targeting by A beta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease. Alzheimers Dement. 2006 Jan; 2(1):43-55. PMID: 19595855.
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    223. Han PK, Moser RP, Klein WM. Perceived ambiguity about cancer prevention recommendations: relationship to perceptions of cancer preventability, risk, and worry. J Health Commun. 2006; 11 Suppl 1:51-69. PMID: 16641074.
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    224. Dillard AJ, McCaul KD, Klein WM. Unrealistic optimism in smokers: implications for smoking myth endorsement and self-protective motivation. J Health Commun. 2006; 11 Suppl 1:93-102. PMID: 16641076.
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    225. Dillard AJ, McCaul KD, Kelso PD, Klein WM. Resisting good news: reactions to breast cancer risk communication. Health Commun. 2006; 19(2):115-23. PMID: 16548702.
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    226. Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem. 2006 Jan 20; 281(3):1599-604. PMID: 16282321.
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    227. Villinski JT, Kiyama T, Dayal S, Zhang N, Liang S, Klein WH. Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins. Dev Genes Evol. 2005 Aug; 215(8):410-22. PMID: 15871032.
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    228. Kiyama T, Zhang N, Dayal S, Yun Lee P, Liang S, Villinski JT, Klein WH. Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer. Dev Biol. 2005 Apr 15; 280(2):436-47. PMID: 15882584.
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    229. Mu X, Fu X, Sun H, Beremand PD, Thomas TL, Klein WH. A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate. Dev Biol. 2005 Apr 15; 280(2):467-81. PMID: 15882586.
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    230. Mu X, Fu X, Sun H, Liang S, Maeda H, Frishman LJ, Klein WH. Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina. Curr Biol. 2005 Mar 29; 15(6):525-30. PMID: 15797020.
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    231. Haes AJ, Chang L, Klein WL, Van Duyne RP. Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. J Am Chem Soc. 2005 Feb 23; 127(7):2264-71. PMID: 15713105.
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    232. Georganopoulou DG, Chang L, Nam JM, Thaxton CS, Mufson EJ, Klein WL, Mirkin CA. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2273-6. PMID: 15695586.
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    233. Martin SE, Mu X, Klein WH. Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2. Differentiation. 2005 Feb; 73(1):18-27. PMID: 15733064.
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    234. Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci. 2004 Nov 10; 24(45):10191-200. PMID: 15537891.
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    235. Liang S, Zhao S, Mu X, Thomas T, Klein WH. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Mol Vis. 2004 Oct 08; 10:773-86. PMID: 15496829.
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    236. Dayal S, Kiyama T, Villinski JT, Zhang N, Liang S, Klein WH. Creation of cis-regulatory elements during sea urchin evolution by co-option and optimization of a repetitive sequence adjacent to the spec2a gene. Dev Biol. 2004 Sep 15; 273(2):436-53. PMID: 15328024.
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    237. Wikramanayake AH, Peterson R, Chen J, Huang L, Bince JM, McClay DR, Klein WH. Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. Genesis. 2004 Jul; 39(3):194-205. PMID: 15282746.
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    238. Wang Z, Chang L, Klein WL, Thatcher GR, Venton DL. Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers. J Med Chem. 2004 Jun 17; 47(13):3329-33. PMID: 15189029.
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    239. Bleijerveld OB, Klein W, Vaandrager AB, Helms JB, Houweling M. Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol. Biochem J. 2004 May 01; 379(Pt 3):711-9. PMID: 14759225.
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    240. Ohtoshi A, Wang SW, Maeda H, Saszik SM, Frishman LJ, Klein WH, Behringer RR. Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1. Curr Biol. 2004 Mar 23; 14(6):530-6. PMID: 15043821.
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    241. Mu X, Beremand PD, Zhao S, Pershad R, Sun H, Scarpa A, Liang S, Thomas TL, Klein WH. Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development. 2004 Mar; 131(6):1197-210. PMID: 14973295.
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    242. Mu X, Klein WH. A gene regulatory hierarchy for retinal ganglion cell specification and differentiation. Semin Cell Dev Biol. 2004 Feb; 15(1):115-23. PMID: 15036214.
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    243. Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry. 2003 Nov 11; 42(44):12749-60. PMID: 14596589.
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    244. Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10417-22. PMID: 12925731.
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    245. Chang L, Bakhos L, Wang Z, Venton DL, Klein WL. Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening. J Mol Neurosci. 2003; 20(3):305-13. PMID: 14501013.
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    246. Wang SW, Mu X, Bowers WJ, Klein WH. Retinal ganglion cell differentiation in cultured mouse retinal explants. Methods. 2002 Dec; 28(4):448-56. PMID: 12507463.
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    247. Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, Klein WL, Krafft GA, Hong ST. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. FASEB J. 2003 Jan; 17(1):118-20. PMID: 12424218.
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    248. Klein WL. Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochem Int. 2002 Nov; 41(5):345-52. PMID: 12176077.
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    249. Yu J, Bakhos L, Chang L, Holterman MJ, Klein WL, Venton DL. Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):51-5. PMID: 12212793.
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    250. Li X, Bhattacharya C, Dayal S, Maity S, Klein WH. Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor. Differentiation. 2002 May; 70(2-3):109-19. PMID: 12076338.
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    251. Klein WL. ADDLs & protofibrils--the missing links? Neurobiol Aging. 2002 Mar-Apr; 23(2):231-5. PMID: 11804707.
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    252. Houweling M, Klein W, Geelen MJ. Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J. 2002 Feb 15; 362(Pt 1):97-104. PMID: 11829744.
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    253. Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res. 2002 Jan 11; 924(2):133-40. PMID: 11750898.
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    254. Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan; 129(2):467-77. PMID: 11807038.
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    255. Brandhorst BP, Klein WH. Molecular patterning along the sea urchin animal-vegetal axis. Int Rev Cytol. 2002; 213:183-232. PMID: 11837893.
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    256. Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA, Beremand PD, Thomas TL, Gan L, Klein WH. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Nucleic Acids Res. 2001 Dec 15; 29(24):4983-93. PMID: 11812828.
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    257. Angerer LM, Oleksyn DW, Levine AM, Li X, Klein WH, Angerer RC. Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes. Development. 2001 Nov; 128(22):4393-404. PMID: 11714666.
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    258. Sumariwalla VM, Klein WH. Similar myogenic functions for myogenin and MRF4 but not MyoD in differentiated murine embryonic stem cells. Genesis. 2001 Aug; 30(4):239-49. PMID: 11536430.
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    259. Yuh CH, Li X, Davidson EH, Klein WH. Correct Expression of spec2a in the sea urchin embryo requires both Otx and other cis-regulatory elements. Dev Biol. 2001 Apr 15; 232(2):424-38. PMID: 11401403.
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    260. Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends Neurosci. 2001 Apr; 24(4):219-24. PMID: 11250006.
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    261. Myer A, Olson EN, Klein WH. MyoD cannot compensate for the absence of myogenin during skeletal muscle differentiation in murine embryonic stem cells. Dev Biol. 2001 Jan 15; 229(2):340-50. PMID: 11203698.
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    262. Wang SW, Kim BS, Ding K, Wang H, Sun D, Johnson RL, Klein WH, Gan L. Requirement for math5 in the development of retinal ganglion cells. Genes Dev. 2001 Jan 01; 15(1):24-9. PMID: 11156601.
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    263. Chromy BA, Lambert MP, Klein WL. Increased Protein Tyrosine Phosphorylation in Apoptotic Neural Cell Death Due to Microtubule Perturbations. Neurotox Res. 2000 Dec; 2(4):357-372. PMID: 25242875.
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    264. Longo VD, Viola KL, Klein WL, Finch CE. Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. J Neurochem. 2000 Nov; 75(5):1977-85. PMID: 11032887.
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    265. Vivian JL, Olson EN, Klein WH. Thoracic skeletal defects in myogenin- and MRF4-deficient mice correlate with early defects in myotome and intercostal musculature. Dev Biol. 2000 Aug 01; 224(1):29-41. PMID: 10898959.
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    266. Wang SW, Gan L, Martin SE, Klein WH. Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b. Mol Cell Neurosci. 2000 Aug; 16(2):141-56. PMID: 10924257.
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    267. Valdez MR, Richardson JA, Klein WH, Olson EN. Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. Dev Biol. 2000 Mar 15; 219(2):287-98. PMID: 10694423.
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    268. Huang L, Li X, El-Hodiri HM, Dayal S, Wikramanayake AH, Klein WH. Involvement of Tcf/Lef in establishing cell types along the animal-vegetal axis of sea urchins. Dev Genes Evol. 2000 Feb; 210(2):73-81. PMID: 10664150.
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    269. Wagner DS, Gan L, Klein WH. Identification of a differentially expressed RNA helicase by gene trapping. Biochem Biophys Res Commun. 1999 Sep 07; 262(3):677-84. PMID: 10471385.
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    270. Li X, Wikramanayake AH, Klein WH. Requirement of SpOtx in cell fate decisions in the sea urchin embryo and possible role as a mediator of beta-catenin signaling. Dev Biol. 1999 Aug 15; 212(2):425-39. PMID: 10433832.
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    271. Vivian JL, Klein WH, Hasty P. Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice. Biotechniques. 1999 Jul; 27(1):154-62. PMID: 10407678.
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    272. Gan L, Wang SW, Huang Z, Klein WH. POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol. 1999 Jun 15; 210(2):469-80. PMID: 10357904.
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    273. Klein WH, Li X. Function and evolution of Otx proteins. Biochem Biophys Res Commun. 1999 May 10; 258(2):229-33. PMID: 10375352.
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    274. Vivian JL, Gan L, Olson EN, Klein WH. A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation. Dev Biol. 1999 Apr 01; 208(1):44-55. PMID: 10075840.
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    275. Olson EN, Klein WH. Muscle minus myoD. Dev Biol. 1998 Oct 15; 202(2):153-6. PMID: 9769168.
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    276. Wagner DS, Gan L, Klein WH. Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: evidence for alternative rRNA production in hematopoietic cells. Biochem Biophys Res Commun. 1998 Sep 29; 250(3):674-81. PMID: 9784405.
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    277. Wikramanayake AH, Huang L, Klein WH. beta-Catenin is essential for patterning the maternally specified animal-vegetal axis in the sea urchin embryo. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9343-8. PMID: 9689082.
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    278. Lin X, Gan L, Klein WH, Wells D. Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):738-43. PMID: 9703997.
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    279. Rawls A, Valdez MR, Zhang W, Richardson J, Klein WH, Olson EN. Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice. Development. 1998 Jul; 125(13):2349-58. PMID: 9609818.
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    280. Xiang M, Gan L, Li D, Chen ZY, Zhou L, O'Malley BW, Klein W, Nathans J. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9445-50. PMID: 9256502.
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    281. Li X, Chuang CK, Mao CA, Angerer LM, Klein WH. Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus. Dev Biol. 1997 Jul 15; 187(2):253-66. PMID: 9242422.
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    282. Myer A, Wagner DS, Vivian JL, Olson EN, Klein WH. Wild-type myoblasts rescue the ability of myogenin-null myoblasts to fuse in vivo. Dev Biol. 1997 May 15; 185(2):127-38. PMID: 9187078.
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    283. Xiang M, Gan L, Li D, Zhou L, Chen ZY, Wagner D, O'Malley BW, Klein W, Nathans J. Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harb Symp Quant Biol. 1997; 62:325-36. PMID: 9598366.
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    284. Wikramanayake AH, Klein WH. Multiple signaling events specify ectoderm and pattern the oral-aboral axis in the sea urchin embryo. Development. 1997 Jan; 124(1):13-20. PMID: 9006063.
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    285. Wang W, Wikramanayake AH, Gonzalez-Rimbau M, Vlahou A, Flytzanis CN, Klein WH. Very early and transient vegetal-plate expression of SpKrox1, a Krüppel/Krox gene from Stronglyocentrotus purpuratus. Mech Dev. 1996 Dec; 60(2):185-95. PMID: 9025071.
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    286. Stevens GR, Zhang C, Berg MM, Lambert MP, Barber K, Cantallops I, Routtenberg A, Klein WL. CNS neuronal focal adhesion kinase forms clusters that co-localize with vinculin. J Neurosci Res. 1996 Nov 15; 46(4):445-55. PMID: 8950704.
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    287. Xiang M, Gan L, Zhou L, Klein WH, Nathans J. Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11950-5. PMID: 8876243.
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    288. Brennan TJ, Olson EN, Klein WH, Winslow JW. Extensive motor neuron survival in the absence of secondary skeletal muscle fiber formation. J Neurosci Res. 1996 Jul 01; 45(1):57-68. PMID: 8811512.
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    289. Zhang C, Qiu HE, Krafft GA, Klein WL. Protein kinase C and F-actin are essential for stimulation of neuronal FAK tyrosine phosphorylation by G-proteins and amyloid beta protein. FEBS Lett. 1996 May 20; 386(2-3):185-8. PMID: 8647278.
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    290. Mao CA, Wikramanayake AH, Gan L, Chuang CK, Summers RG, Klein WH. Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein. Development. 1996 May; 122(5):1489-98. PMID: 8625836.
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    291. Gan L, Xiang M, Zhou L, Wagner DS, Klein WH, Nathans J. POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):3920-5. PMID: 8632990.
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    292. Wang W, Klein WH. A G/C-rich DNA-regulatory element controls positive expression of the sea urchin Lytechinus pictus aboral ectoderm-specific LpS1 gene. DNA Cell Biol. 1996 Feb; 15(2):133-45. PMID: 8634141.
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    293. Chuang CK, Wikramanayake AH, Mao CA, Li X, Klein WH. Transient appearance of Strongylocentrotus purpuratus Otx in micromere nuclei: cytoplasmic retention of SpOtx possibly mediated through an alpha-actinin interaction. Dev Genet. 1996; 19(3):231-7. PMID: 8952065.
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    294. Rawls A, Morris JH, Rudnicki M, Braun T, Arnold HH, Klein WH, Olson EN. Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis. Dev Biol. 1995 Nov; 172(1):37-50. PMID: 7589813.
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    295. Klein W, Horlacher R, Boos W. Molecular analysis of treB encoding the Escherichia coli enzyme II specific for trehalose. J Bacteriol. 1995 Jul; 177(14):4043-52. PMID: 7608078.
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    296. Lambert MP, Sabo S, Zhang C, Enam SA, Klein WL. Constitutive Alzheimer's-type tau epitopes in a neuritogenic rat CNS cell line. Neurobiol Aging. 1995 Jul-Aug; 16(4):583-9. PMID: 8544909.
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    297. Wikramanayake AH, Brandhorst BP, Klein WH. Autonomous and non-autonomous differentiation of ectoderm in different sea urchin species. Development. 1995 May; 121(5):1497-505. PMID: 7789279.
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    298. Gan L, Mao CA, Wikramanayake A, Angerer LM, Angerer RC, Klein WH. An orthodenticle-related protein from Strongylocentrotus purpuratus. Dev Biol. 1995 Feb; 167(2):517-28. PMID: 7875376.
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    299. Venuti JM, Morris JH, Vivian JL, Olson EN, Klein WH. Myogenin is required for late but not early aspects of myogenesis during mouse development. J Cell Biol. 1995 Feb; 128(4):563-76. PMID: 7532173.
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    300. Cheng TC, Tseng BS, Merlie JP, Klein WH, Olson EN. Activation of the myogenin promoter during mouse embryogenesis in the absence of positive autoregulation. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):561-5. PMID: 7831329.
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    301. Lambert MP, Stevens G, Sabo S, Barber K, Wang G, Wade W, Krafft G, Snyder S, Holzman TF, Klein WL. Beta/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells. J Neurosci Res. 1994 Nov 01; 39(4):377-85. PMID: 7533843.
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    302. Zhang C, Lambert MP, Bunch C, Barber K, Wade WS, Krafft GA, Klein WL. Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide. J Biol Chem. 1994 Oct 14; 269(41):25247-50. PMID: 7929215.
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    303. Mao CA, Gan L, Klein WH. Multiple Otx binding sites required for expression of the Strongylocentrotus purpuratus Spec2a gene. Dev Biol. 1994 Sep; 165(1):229-42. PMID: 8088441.
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    304. Olson EN, Klein WH. bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev. 1994 Jan; 8(1):1-8. PMID: 8288123.
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    305. Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 1993 Aug 05; 364(6437):501-6. PMID: 8393145.
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    306. Gan L, Klein WH. A positive cis-regulatory element with a bicoid target site lies within the sea urchin Spec2a enhancer. Dev Biol. 1993 May; 157(1):119-32. PMID: 8097732.
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    307. Venuti JM, Gan L, Kozlowski MT, Klein WH. Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo. Mech Dev. 1993 Apr; 41(1):3-14. PMID: 8389581.
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    308. Pope W, Enam SA, Bawa N, Miller BE, Ghanbari HA, Klein WL. Phosphorylated tau epitope of Alzheimer's disease is coupled to axon development in the avian central nervous system. Exp Neurol. 1993 Mar; 120(1):106-13. PMID: 7682967.
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    309. Tsui HC, Pope WB, Kim CS, Klein WL. Transient expression of adheron molecules during chick retinal development. J Neurobiol. 1992 Aug; 23(6):720-38. PMID: 1431842.
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    310. Martinic M, Lambert MP, Hua S, Klein WL. Cholinergic differentiation in neurogenic basal forebrain cultures. J Neurobiol. 1992 Apr; 23(3):252-69. PMID: 1624933.
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    311. Sirito M, Walker S, Lin Q, Kozlowski MT, Klein WH, Sawadogo M. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers. Gene Expr. 1992; 2(3):231-40. PMID: 1450663.
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    312. Xiang M, Lu SY, Musso M, Karsenty G, Klein WH. A G-string positive cis-regulatory element in the LpS1 promoter binds two distinct nuclear factors distributed non-uniformly in Lytechinus pictus embryos. Development. 1991 Dec; 113(4):1345-55. PMID: 1811948.
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    313. Kozlowski MT, Gan L, Venuti JM, Sawadogo M, Klein WH. Sea urchin USF: a helix-loop-helix protein active in embryonic ectoderm cells. Dev Biol. 1991 Dec; 148(2):625-30. PMID: 1743406.
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    314. Fonseca MI, Aguilar JS, Skorupa AF, Klein WL. Cellular mapping of m2 muscarinic receptors in rat olfactory bulb using an antiserum raised against a cytoplasmic loop peptide. Brain Res. 1991 Nov 01; 563(1-2):163-70. PMID: 1786528.
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    315. Venuti JM, Goldberg L, Chakraborty T, Olson EN, Klein WH. A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6219-23. PMID: 2068103.
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    316. Xiang MQ, Ge T, Tomlinson CR, Klein WH. Structure and promoter activity of the LpS1 genes of Lytechinus pictus. Duplicated exons account for LpS1 proteins with eight calcium binding domains. J Biol Chem. 1991 Jun 05; 266(16):10524-33. PMID: 2037596.
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    317. Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 1991 Jan 17; 349(6306):257-60. PMID: 1987478.
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    318. Gan L, Wessel GM, Klein WH. Regulatory elements from the related spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene. Dev Biol. 1990 Dec; 142(2):346-59. PMID: 1701736.
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    319. Tomlinson CR, Kozlowski MT, Klein WH. Ectoderm nuclei from sea urchin embryos contain a Spec-DNA binding protein similar to the vertebrate transcription factor USF. Development. 1990 Sep; 110(1):259-72. PMID: 2081463.
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    320. Wessel GM, Zhang W, Klein WH. Myosin heavy chain accumulates in dissimilar cell types of the macromere lineage in the sea urchin embryo. Dev Biol. 1990 Aug; 140(2):447-54. PMID: 1695586.
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    321. Gan L, Zhang W, Klein WH. Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements. Dev Biol. 1990 May; 139(1):186-96. PMID: 2328835.
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    322. Tomlinson CR, Klein WH. Temporal and spatial transcriptional regulation of the aboral ectoderm-specific Spec genes during sea urchin embryogenesis. Mol Reprod Dev. 1990 Apr; 25(4):328-38. PMID: 2328125.
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    323. DeMello FG, DeMello MC, Hudson R, Klein WL. Selective expression of factors preventing cholinergic dedifferentiation. J Neurochem. 1990 Mar; 54(3):886-92. PMID: 2406375.
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    324. Tsui HC, Klein WL. Biochemical differentiation of nascent neurite junctions: unilateral localization of adheron components. Brain Res Dev Brain Res. 1990 Feb 01; 51(2):205-16. PMID: 2323029.
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    325. Eldon ED, Montpetit IC, Nguyen T, Decker G, Valdizan MC, Klein WH, Brandhorst BP. Localization of the sea urchin Spec3 protein to cilia and Golgi complexes of embryonic ectoderm cells. Genes Dev. 1990 Jan; 4(1):111-22. PMID: 2407617.
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    326. Wessel GM, Goldberg L, Lennarz WJ, Klein WH. Gastrulation in the sea urchin is accompanied by the accumulation of an endoderm-specific mRNA. Dev Biol. 1989 Dec; 136(2):526-36. PMID: 2583374.
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    327. Wessel GM, Zhang W, Tomlinson CR, Lennarz WJ, Klein WH. Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix. Development. 1989 Jun; 106(2):355-65. PMID: 2591320.
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    328. Xiang MQ, Bédard PA, Wessel G, Filion M, Brandhorst BP, Klein WH. Tandem duplication and divergence of a sea urchin protein belonging to the troponin C superfamily. J Biol Chem. 1988 Nov 15; 263(32):17173-80. PMID: 3182842.
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    329. Hardin PE, Angerer LM, Hardin SH, Angerer RC, Klein WH. Spec2 genes of Strongylocentrotus purpuratus. Structure and differential expression in embryonic aboral ectoderm cells. J Mol Biol. 1988 Aug 05; 202(3):417-31. PMID: 3172223.
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    330. Lankford KL, DeMello FG, Klein WL. D1-type dopamine receptors inhibit growth cone motility in cultured retina neurons: evidence that neurotransmitters act as morphogenic growth regulators in the developing central nervous system. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4567-71. PMID: 3380807.
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    331. Tsui HC, Schubert D, Klein WL. Molecular basis of growth cone adhesion: anchoring of adheron-containing filaments at adhesive loci. J Cell Biol. 1988 Jun; 106(6):2095-108. PMID: 3384855.
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    332. Lambert MP, Megerian T, Garden G, Klein WL. Soluble proteins from rat olfactory bulb promote the survival and differentiation of cultured basal forebrain neurons. Brain Res. 1988 Jun 01; 469(1-2):263-76. PMID: 3401803.
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    333. Lankford KL, DeMello FG, Klein WL. D1-type dopamine receptors inhibit growth cone motility in cultured retina neurons: evidence that neurotransmitters act as morphogenic growth regulators in the developing central nervous system. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2839-43. PMID: 3357895.
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    334. Eldon ED, Angerer LM, Angerer RC, Klein WH. Spec3: embryonic expression of a sea urchin gene whose product is involved in ectodermal ciliogenesis. Genes Dev. 1987 Dec; 1(10):1280-92. PMID: 2828169.
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    335. Hardin SH, Keast MJ, Hardin PE, Klein WH. Use of consensus oligonucleotides for detecting and isolating nucleic acids encoding calcium binding domains of the troponin C superfamily. Biochemistry. 1987 Jun 16; 26(12):3518-23. PMID: 3651394.
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    336. Lankford K, De Mello FG, Klein WL. A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons. Neurosci Lett. 1987 Mar 31; 75(2):169-74. PMID: 2952906.
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    337. Hardin PE, Klein WH. Unusual sequence conservation in the 5' and 3' untranslated regions of the sea urchin spec mRNAs. J Mol Evol. 1987; 25(2):126-33. PMID: 3116272.
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    338. Floyd EE, Gong ZY, Brandhorst BP, Klein WH. Calmodulin gene expression during sea urchin development: persistence of a prevalent maternal protein. Dev Biol. 1986 Feb; 113(2):501-11. PMID: 3753945.
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    339. Tsui HC, Lankford KL, Klein WL. Differentiation of neuronal growth cones: specialization of filopodial tips for adhesive interactions. Proc Natl Acad Sci U S A. 1985 Dec; 82(23):8256-60. PMID: 3865227.
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    340. Hardin SH, Carpenter CD, Hardin PE, Bruskin AM, Klein WH. Structure of the Spec1 gene encoding a major calcium-binding protein in the embryonic ectoderm of the sea urchin, Strongylocentrotus purpuratus. J Mol Biol. 1985 Nov 20; 186(2):243-55. PMID: 2935638.
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    341. Muesing M, Carpenter CD, Klein WH, Polisky B. High-level expression in Escherichia coli of calcium-binding domains of an embryonic sea urchin protein. Gene. 1984 Nov; 31(1-3):155-64. PMID: 6098520.
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    342. Carpenter CD, Bruskin AM, Hardin PE, Keast MJ, Anstrom J, Tyner AL, Brandhorst BP, Klein WH. Novel proteins belonging to the troponin C superfamily are encoded by a set of mRNAs in sea urchin embryos. Cell. 1984 Mar; 36(3):663-71. PMID: 6697391.
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    343. Lynn DA, Angerer LM, Bruskin AM, Klein WH, Angerer RC. Localization of a family of MRNAS in a single cell type and its precursors in sea urchin embryos. Proc Natl Acad Sci U S A. 1983 May; 80(9):2656-60. PMID: 6573676.
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    344. Forney JD, Epstein LM, Preer LB, Rudman BM, Widmayer DJ, Klein WH, Preer JR. Structure and expression of genes for surface proteins in Paramecium. Mol Cell Biol. 1983 Mar; 3(3):466-74. PMID: 6188948.
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    345. Carpenter CD, Bruskin AM, Spain LM, Eldon ED, Klein WH. The 3' untranslated regions of two related mRNAs contain an element highly repeated in the sea urchin genome. Nucleic Acids Res. 1982 Dec 11; 10(23):7829-42. PMID: 6296792.
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    346. Bruskin AM, Bedard PA, Tyner AL, Showman RM, Brandhorst BP, Klein WH. A family of proteins accumulating in ectoderm of sea urchin embryos specified by two related cDNA clones. Dev Biol. 1982 Jun; 91(2):317-24. PMID: 6284573.
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    347. Carpenter CD, Klein WH. A gradient of poly(A)+ RNA sequences in Xenopus laevis eggs and embryos. Dev Biol. 1982 May; 91(1):43-9. PMID: 6896500.
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    348. Bruskin AM, Tyner AL, Wells DE, Showman RM, Klein WH. Accumulation in embryogenesis of five mRNAs enriched in the ectoderm of the sea urchin pluteus. Dev Biol. 1981 Oct 30; 87(2):308-18. PMID: 6169573.
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    349. Wells DE, Showman RM, Klein WH, Raff RA. Delayed recruitment of maternal histone H3 mRNA in sea urchin embryos. Nature. 1981 Jul 30; 292(5822):477-8. PMID: 7254343.
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    350. Klein WL. Multiple binding states of muscarinic acetylcholine receptors in membranes from neuroblastoma x glioma hybrid cells. Biochem Biophys Res Commun. 1980 Apr 29; 93(4):1058-66. PMID: 7396897.
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    351. Klein WL, Nathanson N, Nirenberg M. Muscarinic acetylcholine receptor regulation by accelerated rate of receptor loss. Biochem Biophys Res Commun. 1979 Sep 27; 90(2):506-12. PMID: 508317.
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    352. Conradt P, Müller WF, Loose L, Klein W, Coulston F, Korte F. Incorporation of [3H]uridine into RNA under the influence of dieldrin and polychlorinated biphenyls. Ecotoxicol Environ Saf. 1979 Mar; 3(1):10-7. PMID: 94286.
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    353. Wold BJ, Klein WH, Hough-Evans BR, Britten RJ, Davidson EH. Sea urchin embryo mRNA sequences expressed in the nuclear RNA of adult tissues. Cell. 1978 Aug; 14(4):941-50. PMID: 688400.
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    354. Klein WH, Thomas TL, Lai C, Scheller RH, Britten RJ, Davidson EH. Characteristics of individual repetitive sequence families in the sea urchin genome studied with cloned repeats. Cell. 1978 Aug; 14(4):889-900. PMID: 688398.
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    355. Galau GA, Klein WH, Britten RJ, Davidson EH. Significance of rare m RNA sequences in liver. Arch Biochem Biophys. 1977 Mar; 179(2):584-99. PMID: 851359.
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    356. Davidson EH, Klein WH, Britten RJ. Sequence organization in animal DNA and a speculation on hnRNA as a coordinate regulatory transcript. Dev Biol. 1977 Jan; 55(1):69-84. PMID: 832773.
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    357. Galau GA, Klein WH, Davis MM, Wold BJ, Britten RJ, Davidson EH. Structural gene sets active in embryos and adult tissues of the sea urchin. Cell. 1976 Apr; 7(4):487-505. PMID: 986248.
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    358. Davidson EH, Hough BR, Klein WH, Britten RJ. Structural genes adjacent to interspersed repetitive DNA sequences. Cell. 1975 Mar; 4(3):217-38. PMID: 1122554.
      View in: PubMed
    359. Ismail R, Hockwin O, Korte F, Klein W. Proceedings: Permeability of the isolated bovine lens capsule for environmental chemicals. Exp Eye Res. 1975 Feb; 20(2):179. PMID: 1122969.
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    360. Klein WH, Murphy W, Attardi G, Britten RJ, Davidson EH. Distribution of repetitive and nonrepetivite sequence transcripts in HeLa mRNA. Proc Natl Acad Sci U S A. 1974 May; 71(5):1785-9. PMID: 4525461.
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    361. Clark JM, Klein WH. In vitro translation of STNV-RNA. Methods Enzymol. 1974; 30:754-61. PMID: 4604593.
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    362. Klein WH, Clark JM. N-terminal sequence of the eucaryotic in vitro product made upon translation of satellite tobacco necrosis virus ribonucleic acid. Biochemistry. 1973 Apr 10; 12(8):1528-31. PMID: 4699985.
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    363. Lundquist RE, Lazar JM, Klein WH, Clark JM. Translation of satellite tobacco necrosis virus ribonucleic acid. II. Initiation of in vitro translation in procaryotic and eucaryotic systems. Biochemistry. 1972 May 23; 11(11):2014-9. PMID: 4337485.
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    364. Klein WH, Nolan C, Lazar JM, Clark JM. Translation of satellite tobacco necrosis virus ribonucleic acid. I. Characterization of in vitro procaryotic and eucaryotic translation products. Biochemistry. 1972 May 23; 11(11):2009-14. PMID: 4554894.
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    365. Developmental biology of the retina. Seminars in Cell and Developmental Biology. 15:51.
    366. Erratum. Developmental Biology. 174:453.
    367. Type i interferons regulate eomesodermin expression and the development of unconventional memory CD8 <sup>+</sup> T cells. Nature Communications. 6.
    368. Erratum. Developmental Biology. 210:513.
    369. Erratum. Genesis. 31:95-96.
    370. [29]Spec proteins. Methods. 139:354-363.
    371. Development of the vertebrate retina. Methods. 28:385-386.
    372. Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proceedings of the Royal Society B: Biological Sciences. 283.
    373. Manipulating cell fates in the sea urchin embryo. Invertebrate Reproduction and Development. 31:21-29.
    374. Erratum. Biochemical and Biophysical Research Communications. 260:575.
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