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VIDYA GOPALAKRISHNAN

TitleAssociate Professor
InstitutionMD Anderson
DepartmentPediatrics
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bailey CP, Figueroa M, Gangadharan A, Yang Y, Romero MM, Kennis BA, Yadavilli S, Henry V, Collier T, Monje M, Lee DA, Wang L, Nazarian J, Gopalakrishnan V, Zaky W, Becher OJ, Chandra J. Pharmacologic inhibition of lysine specific demethylase-1 (LSD1) as a therapeutic and immune-sensitization strategy in pediatric high grade glioma (pHGG). Neuro Oncol. 2020 Mar 13. PMID: 32166329.
      View in: PubMed
    2. Khatua S, Cooper LJN, Sandberg DI, Ketonen L, Johnson JM, Rytting ME, Liu DD, Meador H, Trikha P, Nakkula RJ, Behbehani GK, Ragoonanan D, Gupta S, Kotrotsou A, Idris T, Shpall EJ, Rezvani K, Colen R, Zaky W, Lee DA, Gopalakrishnan V. Phase I study of intraventricular infusions of autologous ex-vivo-expanded NK cells in children with recurrent medulloblastoma and ependymoma. Neuro Oncol. 2020 Mar 10. PMID: 32152626.
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    3. Harmanci A, Harmanci AS, Swaminathan J, Gopalakrishnan V. EpiSAFARI: sensitive detection of valleys in epigenetic signals for enhancing annotations of functional elements. Bioinformatics. 2020 Feb 15; 36(4):1014-1021. PMID: 31501853.
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    4. Koroth J, Nirgude S, Tiwari S, Gopalakrishnan V, Mahadeva R, Kumar S, Karki SS, Choudhary B. Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines. BMC Complement Altern Med. 2019 Oct 21; 19(1):273. PMID: 31638975.
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    5. Kennis BA, Michel KA, Brugmann WB, Laureano A, Tao RH, Somanchi SS, Einstein SA, Bravo-Alegria JB, Maegawa S, Wahba A, Kiany S, Gordon N, Silla L, Schellingerhout D, Khatua S, Zaky W, Sandberg D, Cooper L, Lee DA, Bankson JA, Gopalakrishnan V. Correction to: Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI. J Neurooncol. 2019 May; 142(3):409. PMID: 30968268.
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    6. Kennis BA, Michel KA, Brugmann WB, Laureano A, Tao RH, Somanchi SS, Einstein SA, Bravo-Alegria JB, Maegawa S, Wahba A, Kiany S, Gordon N, Silla L, Schellingerhout D, Khatua S, Zaky W, Sandberg D, Cooper L, Lee DA, Bankson JA, Gopalakrishnan V. Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI. J Neurooncol. 2019 May; 142(3):395-407. PMID: 30788681.
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    7. Dobson THW, Tao RH, Swaminathan J, Maegawa S, Shaik S, Bravo-Alegria J, Sharma A, Kennis B, Yang Y, Callegari K, Haltom AR, Taylor P, Kogiso M, Qi L, Khatua S, Goldman S, Lulla RR, Fangusaro J, MacDonald TJ, Li XN, Hawkins C, Rajaram V, Gopalakrishnan V. Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma. Sci Signal. 2019 01 22; 12(565). PMID: 30670636.
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    8. Dobson THW, Gopalakrishnan V. Preclinical Models of Pediatric Brain Tumors-Forging Ahead. Bioengineering (Basel). 2018 Oct 02; 5(4). PMID: 30279402.
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    9. Callegari K, Maegawa S, Bravo-Alegria J, Gopalakrishnan V. Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration. Cell Commun Signal. 2018 09 18; 16(1):60. PMID: 30227871.
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    10. Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Mol Cell. 2018 06 07; 70(5):825-841.e6. PMID: 29861161.
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    11. Shaik S, Kennis B, Maegawa S, Schadler K, Yanwen Y, Callegari K, Lulla RR, Goldman S, Nazarian J, Rajaram V, Fangusaro J, Gopalakrishnan V. REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature. Oncotarget. 2018 Jan 12; 9(4):5233-5250. PMID: 29435175.
      View in: PubMed
    12. Zaky W, Manton C, Miller CP, Khatua S, Gopalakrishnan V, Chandra J. The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities. Cancer Metastasis Rev. 2017 12; 36(4):617-633. PMID: 29071526.
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    13. Nolo R, Herbrich S, Rao A, Zweidler-McKay P, Kannan S, Gopalakrishnan V. Targeting P-selectin blocks neuroblastoma growth. Oncotarget. 2017 Oct 17; 8(49):86657-86670. PMID: 29156825.
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    14. Hegde M, Vartak SV, Kavitha CV, Ananda H, Prasanna DS, Gopalakrishnan V, Choudhary B, Rangappa KS, Raghavan SC. A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells. Sci Rep. 2017 05 31; 7(1):2533. PMID: 28566733.
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    15. Dobson THW, Hatcher RJ, Swaminathan J, Das CM, Shaik S, Tao RH, Milite C, Castellano S, Taylor PH, Sbardella G, Gopalakrishnan V. Regulation of USP37 Expression by REST-Associated G9a-Dependent Histone Methylation. Mol Cancer Res. 2017 08; 15(8):1073-1084. PMID: 28483947.
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    16. Thomas E, Gopalakrishnan V, Hegde M, Kumar S, Karki SS, Raghavan SC, Choudhary B. A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells. Sci Rep. 2016 10 17; 6:34653. PMID: 27748367.
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    17. Vartak SV, Hegde M, Iyer D, Gaikwad S, Gopalakrishnan V, Srivastava M, Karki SS, Choudhary B, Ray P, Santhoshkumar TR, Raghavan SC. A novel inhibitor of BCL2, Disarib abrogates tumor growth while sparing platelets, by activating intrinsic pathway of apoptosis. Biochem Pharmacol. 2016 Dec 15; 122:10-22. PMID: 27693384.
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    18. Iyer D, Vartak SV, Mishra A, Goldsmith G, Kumar S, Srivastava M, Hegde M, Gopalakrishnan V, Glenn M, Velusamy M, Choudhary B, Kalakonda N, Karki SS, Surolia A, Raghavan SC. Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain. FEBS J. 2016 09; 283(18):3408-37. PMID: 27444341.
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    19. Thomas E, Gopalakrishnan V, Somasagara RR, Choudhary B, Raghavan SC. Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse. Sci Rep. 2016 Mar 24; 6:23255. PMID: 27009490.
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    20. Somanchi SS, Kennis BA, Gopalakrishnan V, Lee DA, Bankson JA. In Vivo (19)F-Magnetic Resonance Imaging of Adoptively Transferred NK Cells. Methods Mol Biol. 2016; 1441:317-32. PMID: 27177678.
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    21. Sandberg DI, Rytting M, Zaky W, Kerr M, Ketonen L, Kundu U, Moore BD, Yang G, Hou P, Sitton C, Cooper LJ, Gopalakrishnan V, Lee DA, Thall PF, Khatua S. Methotrexate administration directly into the fourth ventricle in children with malignant fourth ventricular brain tumors: a pilot clinical trial. J Neurooncol. 2015 Oct; 125(1):133-41. PMID: 26255071.
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    22. Gopalakrishnan V, Tao RH, Dobson T, Brugmann W, Khatua S. Medulloblastoma development: tumor biology informs treatment decisions. CNS Oncol. 2015; 4(2):79-89. PMID: 25768332.
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    23. Kumar S, Gopalakrishnan V, Hegde M, Rana V, Dhepe SS, Ramareddy SA, Leoni A, Locatelli A, Morigi R, Rambaldi M, Srivastava M, Raghavan SC, Karki SS. Synthesis and antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives. Bioorg Med Chem Lett. 2014 Oct 01; 24(19):4682-4688. PMID: 25205189.
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    24. Kumar S, Hegde M, Gopalakrishnan V, Renuka VK, Ramareddy SA, De Clercq E, Schols D, Gudibabande Narasimhamurthy AK, Raghavan SC, Karki SS. 2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action. Eur J Med Chem. 2014 Sep 12; 84:687-97. PMID: 25064346.
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    25. Nambiar M, Srivastava M, Gopalakrishnan V, Sankaran SK, Raghavan SC. G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia. Mol Cell Biol. 2013 Nov; 33(21):4266-81. PMID: 24001773.
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    26. Taylor P, Fangusaro J, Rajaram V, Goldman S, Helenowski IB, MacDonald T, Hasselblatt M, Riedemann L, Laureano A, Cooper L, Gopalakrishnan V. REST is a novel prognostic factor and therapeutic target for medulloblastoma. Mol Cancer Ther. 2012 Aug; 11(8):1713-1723. PMID: 22848092.
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    27. Das CM, Taylor P, Gireud M, Singh A, Lee D, Fuller G, Ji L, Fangusaro J, Rajaram V, Goldman S, Eberhart C, Gopalakrishnan V. The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. Oncogene. 2013 Mar 28; 32(13):1691-701. PMID: 22665064.
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    28. Singh A, Rokes C, Gireud M, Fletcher S, Baumgartner J, Fuller G, Stewart J, Zage P, Gopalakrishnan V. Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(ß-TRCP) in neuroblastoma cells. Cancer. 2011 Nov 15; 117(22):5189-202. PMID: 21523764.
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    29. Schreck KC, Taylor P, Marchionni L, Gopalakrishnan V, Bar EE, Gaiano N, Eberhart CG. The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res. 2010 Dec 15; 16(24):6060-70. PMID: 21169257.
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    30. Das CM, Zage PE, Taylor P, Aguilera D, Wolff JE, Lee D, Gopalakrishnan V. Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines. Eur J Cancer. 2010 Oct; 46(15):2771-80. PMID: 20886683.
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    31. Gopalakrishnan V, Bie B, Sinnappah-Kang ND, Adams H, Fuller GN, Pan ZZ, Majumder S. Myoblast-derived neuronal cells form glutamatergic neurons in the mouse cerebellum. Stem Cells. 2010 Oct; 28(10):1839-47. PMID: 20799335.
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    32. Aguilera DG, Das CM, Sinnappah-Kang ND, Joyce C, Taylor PH, Wen S, Hasselblatt M, Paulus W, Fuller G, Wolff JE, Gopalakrishnan V. Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL. J Neurooncol. 2009 Jul; 93(3):303-18. PMID: 19148581.
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    33. Gopalakrishnan V. REST and the RESTless: in stem cells and beyond. Future Neurol. 2009; 4(3):317-329. PMID: 19885378.
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    34. Prasad P, Vasquez H, Das CM, Gopalakrishnan V, Wolff JE. Histone acetylation resulting in resistance to methotrexate in choroid plexus cells. J Neurooncol. 2009 Feb; 91(3):279-86. PMID: 18853233.
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    35. Masoudi A, Elopre M, Amini E, Nagel ME, Ater JL, Gopalakrishnan V, Wolff JE. Influence of valproic acid on outcome of high-grade gliomas in children. Anticancer Res. 2008 Jul-Aug; 28(4C):2437-42. PMID: 18751431.
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    36. Das CM, Aguilera D, Vasquez H, Prasad P, Zhang M, Wolff JE, Gopalakrishnan V. Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines. J Neurooncol. 2007 Nov; 85(2):159-70. PMID: 17534580.
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    37. Zhang M, Aguilera D, Das C, Vasquez H, Zage P, Gopalakrishnan V, Wolff J. Measuring cytotoxicity: a new perspective on LC50. Anticancer Res. 2007 Jan-Feb; 27(1A):35-8. PMID: 17352213.
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    38. Zhang M, Das C, Vasquez H, Aguilera D, Zage PE, Gopalakrishnan V, Wolff JE. Predicting tumor cell repopulation after response: mathematical modeling of cancer cell growth. Anticancer Res. 2006 Jul-Aug; 26(4B):2933-6. PMID: 16886616.
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    39. Su X, Gopalakrishnan V, Stearns D, Aldape K, Lang FF, Fuller G, Snyder E, Eberhart CG, Majumder S. Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation. Mol Cell Biol. 2006 Mar; 26(5):1666-78. PMID: 16478988.
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    40. Watanabe Y, Kameoka S, Gopalakrishnan V, Aldape KD, Pan ZZ, Lang FF, Majumder S. Conversion of myoblasts to physiologically active neuronal phenotype. Genes Dev. 2004 Apr 15; 18(8):889-900. PMID: 15078815.
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    41. Gopalakrishnan V, Simancek P, Houchens C, Snaith HA, Frattini MG, Sazer S, Kelly TJ. Redundant control of rereplication in fission yeast. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13114-9. PMID: 11606752.
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    42. Gopalakrishnan V, Sheahan L, Khan SA. DNA replication specificity and functional E2 interaction of the E1 proteins of human papillomavirus types 1a and 18 are determined by their carboxyl-terminal halves. Virology. 1999 Apr 10; 256(2):330-9. PMID: 10191198.
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    43. Khan SA, Sheikh S, Sheahan L, Van Horn G, Gopalakrishnan V, Sverdrup F. Expression of E1 protein of human papillomaviruses in eukaryotic cells. Methods Enzymol. 1999; 306:328-36. PMID: 10432463.
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    44. Gopalakrishnan V, Walker S, Khan SA. Stimulation of human papillomavirus type 1a DNA replication by a multimerized AT-rich palindromic sequence. Virology. 1995 Dec 01; 214(1):301-6. PMID: 8525634.
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    45. Gopalakrishnan V, Khan SA. E1 protein of human papillomavirus type 1a is sufficient for initiation of viral DNA replication. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9597-601. PMID: 7937813.
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    46. The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation. Oncogene.
    47. In vivo 19F-magnetic resonance imaging of adoptively transferred NK cells. 317-332.
    48. Rest and the restless. Future Neurology. 4:317-329.
    49. Methotrexate administration directly into the fourth ventricle in children with malignant fourth ventricular brain tumors. Journal of Neuro-Oncology. 125:133-141.
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