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VICTOR KRASNYKH

TitleAssociate Professor
InstitutionMD Anderson
DepartmentCancer Systems Imaging
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wu Y, Fang B, Yang XQ, Wang L, Chen D, Krasnykh V, Carter BZ, Morris JS, Shureiqi I. Therapeutic Molecular Targetingof 15-Lipoxygenase-1 in Colon Cancer. Mol Ther. 2008 May; 16(5):886-892. PMID: 28178489.
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    2. Belousova N, Mikheeva G, Xiong C, Stagg LJ, Gagea M, Fox PS, Bassett RL, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V. Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. Oncotarget. 2016 Aug 16; 7(33):53414-53429. PMID: 27462785.
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    3. Dreier B, Honegger A, Hess C, Nagy-Davidescu G, Mittl PR, Grütter MG, Belousova N, Mikheeva G, Krasnykh V, Plückthun A. Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters. Proc Natl Acad Sci U S A. 2013 Mar 05; 110(10):E869-77. PMID: 23431166.
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    4. Yeh HH, Ogawa K, Balatoni J, Mukhapadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1603-8. PMID: 21220318.
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    5. Dreier B, Mikheeva G, Belousova N, Parizek P, Boczek E, Jelesarov I, Forrer P, Plückthun A, Krasnykh V. Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting. J Mol Biol. 2011 Jan 14; 405(2):410-26. PMID: 21056576.
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    6. Belousova N, Mikheeva G, Xiong C, Soghomonian S, Young D, Le Roux L, Naff K, Bidaut L, Wei W, Li C, Gelovani J, Krasnykh V. Development of a targeted gene vector platform based on simian adenovirus serotype 24. J Virol. 2010 Oct; 84(19):10087-101. PMID: 20631120.
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    7. Glasgow JN, Mikheeva G, Krasnykh V, Curiel DT. A strategy for adenovirus vector targeting with a secreted single chain antibody. PLoS One. 2009 Dec 21; 4(12):e8355. PMID: 20027223.
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    8. Piao Y, Jiang H, Alemany R, Krasnykh V, Marini FC, Xu J, Alonso MM, Conrad CA, Aldape KD, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity. Cancer Gene Ther. 2009 Mar; 16(3):256-65. PMID: 18927600.
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    9. Wu Y, Fang B, Yang XQ, Wang L, Chen D, Krasnykh V, Carter BZ, Morris JS, Shureiqi I. Therapeutic molecular targeting of 15-lipoxygenase-1 in colon cancer. Mol Ther. 2008 May; 16(5):886-92. PMID: 18388920.
      View in: PubMed
    10. Belousova N, Mikheeva G, Gelovani J, Krasnykh V. Modification of adenovirus capsid with a designed protein ligand yields a gene vector targeted to a major molecular marker of cancer. J Virol. 2008 Jan; 82(2):630-7. PMID: 17989185.
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    11. Hosokawa M, Kadota R, Shichijo S, Itoh K, Dmitriev I, Krasnykh V, Curiel DT, Takue Y, Wakasugi H, Takashima S, Heike Y. Cell cycle arrest and apoptosis induced by SART-1 gene transduction. Anticancer Res. 2005 May-Jun; 25(3B):1983-90. PMID: 16158934.
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    12. Wu H, Han T, Belousova N, Krasnykh V, Kashentseva E, Dmitriev I, Kataram M, Mahasreshti PJ, Curiel DT. Identification of sites in adenovirus hexon for foreign peptide incorporation. J Virol. 2005 Mar; 79(6):3382-90. PMID: 15731232.
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    13. Wang M, Hemminki A, Siegal GP, Barnes MN, Dmitriev I, Krasnykh V, Liu B, Curiel DT, Alvarez RD. Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery. Gynecol Oncol. 2005 Feb; 96(2):341-8. PMID: 15661219.
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    14. Ono HA, Davydova JG, Adachi Y, Takayama K, Barker SD, Reynolds PN, Krasnykh VN, Kunisaki C, Shimada H, Curiel DT, Yamamoto M. Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer. J Gastroenterol. 2005 Jan; 40(1):31-42. PMID: 15692787.
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    15. Rivera AA, Davydova J, Schierer S, Wang M, Krasnykh V, Yamamoto M, Curiel DT, Nettelbeck DM. Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells. Gene Ther. 2004 Dec; 11(23):1694-702. PMID: 15496964.
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    16. Zinn KR, Szalai AJ, Stargel A, Krasnykh V, Chaudhuri TR. Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus. Gene Ther. 2004 Oct; 11(19):1482-6. PMID: 15295616.
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    17. Davydova J, Le LP, Gavrikova T, Wang M, Krasnykh V, Yamamoto M. Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment. Cancer Res. 2004 Jun 15; 64(12):4319-27. PMID: 15205347.
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    18. Rivera AA, Wang M, Suzuki K, Uil TG, Krasnykh V, Curiel DT, Nettelbeck DM. Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo. Virology. 2004 Mar 01; 320(1):121-34. PMID: 15003868.
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    19. Grandi P, Wang S, Schuback D, Krasnykh V, Spear M, Curiel DT, Manservigi R, Breakefield XO. HSV-1 virions engineered for specific binding to cell surface receptors. Mol Ther. 2004 Mar; 9(3):419-27. PMID: 15006609.
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    20. Timares L, Douglas JT, Tillman BW, Krasnykh V, Curiel DT. Adenovirus-mediated gene delivery to dendritic cells. Methods Mol Biol. 2004; 246:139-54. PMID: 14970589.
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    21. Korokhov N, Mikheeva G, Krendelshchikov A, Belousova N, Simonenko V, Krendelshchikova V, Pereboev A, Kotov A, Kotova O, Triozzi PL, Aldrich WA, Douglas JT, Lo KM, Banerjee PT, Gillies SD, Curiel DT, Krasnykh V. Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge. J Virol. 2003 Dec; 77(24):12931-40. PMID: 14645549.
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    22. Belousova N, Korokhov N, Krendelshchikova V, Simonenko V, Mikheeva G, Triozzi PL, Aldrich WA, Banerjee PT, Gillies SD, Curiel DT, Krasnykh V. Genetically targeted adenovirus vector directed to CD40-expressing cells. J Virol. 2003 Nov; 77(21):11367-77. PMID: 14557622.
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    23. Yamamoto M, Davydova J, Wang M, Siegal GP, Krasnykh V, Vickers SM, Curiel DT. Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology. 2003 Oct; 125(4):1203-18. PMID: 14517802.
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    24. Takayama K, Reynolds PN, Short JJ, Kawakami Y, Adachi Y, Glasgow JN, Rots MG, Krasnykh V, Douglas JT, Curiel DT. A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism. Virology. 2003 May 10; 309(2):282-93. PMID: 12758175.
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    25. Kim M, Sumerel LA, Belousova N, Lyons GR, Carey DE, Krasnykh V, Douglas JT. The coxsackievirus and adenovirus receptor acts as a tumour suppressor in malignant glioma cells. Br J Cancer. 2003 May 06; 88(9):1411-6. PMID: 12778071.
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    26. Chaudhuri TR, Cao Z, Krasnykh VN, Stargel AV, Belousova N, Partridge EE, Zinn KR. Blood-based screening and light based imaging for the early detection and monitoring of ovarian cancer xenografts. Technol Cancer Res Treat. 2003 Apr; 2(2):171-80. PMID: 12680799.
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    27. Kawakami Y, Li H, Lam JT, Krasnykh V, Curiel DT, Blackwell JL. Substitution of the adenovirus serotype 5 knob with a serotype 3 knob enhances multiple steps in virus replication. Cancer Res. 2003 Mar 15; 63(6):1262-9. PMID: 12649186.
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    28. Nagi P, Vickers SM, Davydova J, Adachi Y, Takayama K, Barker S, Krasnykh V, Curiel DT, Yamamoto M. Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement. J Gastrointest Surg. 2003 Mar-Apr; 7(3):364-71. PMID: 12654561.
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    29. Pereboeva L, Komarova S, Mikheeva G, Krasnykh V, Curiel DT. Approaches to utilize mesenchymal progenitor cells as cellular vehicles. Stem Cells. 2003; 21(4):389-404. PMID: 12832693.
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    30. Sullivan DE, Mondelli MU, Curiel DT, Krasnykh V, Mikheeva G, Gaglio P, Morris CB, Dash S, Gerber MA. Construction and characterization of an intracellular single-chain human antibody to hepatitis C virus non-structural 3 protein. J Hepatol. 2002 Nov; 37(5):660-8. PMID: 12399234.
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    31. Kim M, Zinn KR, Barnett BG, Sumerel LA, Krasnykh V, Curiel DT, Douglas JT. The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells. Eur J Cancer. 2002 Sep; 38(14):1917-26. PMID: 12204675.
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    32. Belousova N, Krendelchtchikova V, Curiel DT, Krasnykh V. Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein. J Virol. 2002 Sep; 76(17):8621-31. PMID: 12163581.
      View in: PubMed
    33. Haviv YS, Blackwell JL, Kanerva A, Nagi P, Krasnykh V, Dmitriev I, Wang M, Naito S, Lei X, Hemminki A, Carey D, Curiel DT. Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors. Cancer Res. 2002 Aug 01; 62(15):4273-81. PMID: 12154029.
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    34. Zinn KR, Chaudhuri TR, Krasnykh VN, Buchsbaum DJ, Belousova N, Grizzle WE, Curiel DT, Rogers BE. Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus in mice. Radiology. 2002 May; 223(2):417-25. PMID: 11997547.
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    35. Bauerschmitz GJ, Lam JT, Kanerva A, Suzuki K, Nettelbeck DM, Dmitriev I, Krasnykh V, Mikheeva GV, Barnes MN, Alvarez RD, Dall P, Alemany R, Curiel DT, Hemminki A. Treatment of ovarian cancer with a tropism modified oncolytic adenovirus. Cancer Res. 2002 Mar 01; 62(5):1266-70. PMID: 11888888.
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    36. Kanerva A, Mikheeva GV, Krasnykh V, Coolidge CJ, Lam JT, Mahasreshti PJ, Barker SD, Straughn M, Barnes MN, Alvarez RD, Hemminki A, Curiel DT. Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells. Clin Cancer Res. 2002 Jan; 8(1):275-80. PMID: 11801569.
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    37. Wesseling JG, Bosma PJ, Krasnykh V, Kashentseva EA, Blackwell JL, Reynolds PN, Li H, Parameshwar M, Vickers SM, Jaffee EM, Huibregtse K, Curiel DT, Dmitriev I. Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors. Gene Ther. 2001 Jul; 8(13):969-76. PMID: 11438831.
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    38. Krasnykh V, Belousova N, Korokhov N, Mikheeva G, Curiel DT. Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol. 2001 May; 75(9):4176-83. PMID: 11287567.
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    39. Cripe TP, Dunphy EJ, Holub AD, Saini A, Vasi NH, Mahller YY, Collins MH, Snyder JD, Krasnykh V, Curiel DT, Wickham TJ, DeGregori J, Bergelson JM, Currier MA. Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells. Cancer Res. 2001 Apr 01; 61(7):2953-60. PMID: 11306473.
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    40. Asada-Mikami R, Heike Y, Kanai S, Azuma M, Shirakawa K, Takaue Y, Krasnykh V, Curiel DT, Terada M, Abe T, Wakasugi H. Efficient gene transduction by RGD-fiber modified recombinant adenovirus into dendritic cells. Jpn J Cancer Res. 2001 Mar; 92(3):321-7. PMID: 11267943.
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    41. Suzuki K, Fueyo J, Krasnykh V, Reynolds PN, Curiel DT, Alemany R. A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency. Clin Cancer Res. 2001 Jan; 7(1):120-6. PMID: 11205899.
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    42. Krasnykh V, Dmitriev I, Navarro JG, Belousova N, Kashentseva E, Xiang J, Douglas JT, Curiel DT. Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity. Cancer Res. 2000 Dec 15; 60(24):6784-7. PMID: 11156365.
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    43. Blackwell JL, Li H, Gomez-Navarro J, Dmitriev I, Krasnykh V, Richter CA, Shaw DR, Alvarez RD, Curiel DT, Strong TV. Using a tropism-modified adenoviral vector to circumvent inhibitory factors in ascites fluid. Hum Gene Ther. 2000 Aug 10; 11(12):1657-69. PMID: 10954900.
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    44. Dmitriev I, Kashentseva E, Rogers BE, Krasnykh V, Curiel DT. Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells. J Virol. 2000 Aug; 74(15):6875-84. PMID: 10888627.
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    45. Krasnykh VN, Douglas JT, van Beusechem VW. Genetic targeting of adenoviral vectors. Mol Ther. 2000 May; 1(5 Pt 1):391-405. PMID: 10933960.
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    46. Kasono K, Blackwell JL, Douglas JT, Dmitriev I, Strong TV, Reynolds P, Kropf DA, Carroll WR, Peters GE, Bucy RP, Curiel DT, Krasnykh V. Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector. Clin Cancer Res. 1999 Sep; 5(9):2571-9. PMID: 10499635.
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    47. Bilbao G, Contreras JL, Eckhoff DE, Mikheeva G, Krasnykh V, Douglas JT, Thomas FT, Thomas JM, Curiel DT. Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene. Ann Surg. 1999 Aug; 230(2):185-93. PMID: 10450732.
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    48. Bilbao G, Contreras JL, Zhang HG, Pike MJ, Overturf K, Mikheeva G, Krasnykh V, Curiel DT. Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene. J Virol. 1999 Aug; 73(8):6992-7000. PMID: 10400798.
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    49. Vanderkwaak TJ, Wang M, Gómez-Navarro J, Rancourt C, Dmitriev I, Krasnykh V, Barnes M, Siegal GP, Alvarez R, Curiel DT. An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches. Gynecol Oncol. 1999 Aug; 74(2):227-34. PMID: 10419736.
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    50. Douglas JT, Miller CR, Kim M, Dmitriev I, Mikheeva G, Krasnykh V, Curiel DT. A system for the propagation of adenoviral vectors with genetically modified receptor specificities. Nat Biotechnol. 1999 May; 17(5):470-5. PMID: 10331807.
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    51. Bilbao G, Contreras JL, Gómez-Navarro J, Eckhoff DE, Mikheeva G, Krasnykh V, Hynes T, Thomas FT, Thomas JM, Curiel DT. Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation. Transplantation. 1999 Mar 27; 67(6):775-83. PMID: 10199723.
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    52. Bilbao G, Contreras JL, Mikheeva G, Krasnykh V, Eckhoff DE, Thomas FT, Thomas J, Curiel DT. Genetic cytoprotection of human endothelial cells during preservation time with an adenoviral vector encoding the anti-apoptotic human Bcl-2 gene. Transplant Proc. 1999 Feb-Mar; 31(1-2):1012-5. PMID: 10083450.
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    53. Dmitriev I, Krasnykh V, Miller CR, Wang M, Kashentseva E, Mikheeva G, Belousova N, Curiel DT. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol. 1998 Dec; 72(12):9706-13. PMID: 9811704.
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    54. Zinn KR, Douglas JT, Smyth CA, Liu HG, Wu Q, Krasnykh VN, Mountz JD, Curiel DT, Mountz JM. Imaging and tissue biodistribution of 99mTc-labeled adenovirus knob (serotype 5). Gene Ther. 1998 Jun; 5(6):798-808. PMID: 9747460.
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    55. Krasnykh V, Dmitriev I, Mikheeva G, Miller CR, Belousova N, Curiel DT. Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J Virol. 1998 Mar; 72(3):1844-52. PMID: 9499035.
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    56. Krasnykh VN, Mikheeva GV, Douglas JT, Curiel DT. Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism. J Virol. 1996 Oct; 70(10):6839-46. PMID: 8794325.
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    57. Rosenfeld ME, Wang M, Siegal GP, Alvarez RD, Mikheeva G, Krasnykh V, Curiel DT. Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma. J Mol Med (Berl). 1996 Aug; 74(8):455-62. PMID: 8872859.
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    58. Ganguly TC, Krasnykh V, Falany CN. Bacterial expression and kinetic characterization of the human monoamine-sulfating form of phenol sulfotransferase. Drug Metab Dispos. 1995 Sep; 23(9):945-50. PMID: 8565785.
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    59. Blinov VM, Totmenin AV, Resenchuk SM, Olenina LV, Chizhikov VE, Kolykhalov AA, Frolov IV, Gutorov VV, Pozdniakov SG, Krasnykh VN, et al. [Study of the structure-function organization of the variola virus genome. IV. Sequencing and analysis of the nucleotide sequence of the right terminus of the India-1967 strain genome]. Mol Biol (Mosk). 1995 Jul-Aug; 29(4):772-89. PMID: 7476944.
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    60. Falany CN, Krasnykh V, Falany JL. Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase. J Steroid Biochem Mol Biol. 1995 Jun; 52(6):529-39. PMID: 7779757.
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    61. Degtyarev SKh, Prikhod'ko EA, Rechkunova NI, Prikhod'ko GG, Krasnykh VN. Biochemical characterization of VspI methyltransferase. Gene. 1995 May 19; 157(1-2):65-6. PMID: 7607528.
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    62. Falany JL, Krasnykh V, Mikheeva G, Falany CN. Isolation and expression of an isoform of rat estrogen sulfotransferase. J Steroid Biochem Mol Biol. 1995 Jan; 52(1):35-44. PMID: 7857871.
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    63. Prikhod'ko EA, Prikhod'ko GG, Krasnykh VN. Vspl methylase belongs to m6A-gamma class of adenine methylases. Nucleic Acids Res. 1993 Apr 25; 21(8):2015. PMID: 8493116.
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    64. Beklemishev AB, Golovin SIa, Il'ichev AA, Mamaev LV, Krasnykh VN. [Expression in Escherichia coli cells of the nucleotide sequence of DNA coding for the bovine lipotropic hormone]. Mol Gen Mikrobiol Virusol. 1987 Oct; (10):19-23. PMID: 3323897.
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    65. Gorbunov IuA, Daniliuk NK, Il'ichev AA, Krasnykh VN, Lomakin AI. [Chemico-enzymatic synthesis of genetic elements for expression of synthetic genes in Bacillus subtilis cells]. Bioorg Khim. 1986 May; 12(5):647-54. PMID: 3089232.
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    66. Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. Oncotarget. 7:53414-53429.
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