STEPHANIE S WATOWICH

TitleProfessor
InstitutionMD Anderson
DepartmentImmunology
Address7455 Fannin St
Houston TX 77054-1901
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marié IJ, Brambilla L, Azzouz D, Chen Z, Baracho GV, Arnett A, Li HS, Liu W, Cimmino L, Chattopadhyay P, Silverman G, Watowich SS, Khor B, Levy DE. Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome. Elife. 2021 08 11; 10. PMID: 34378531.
      Citations: 1     Fields:    
    2. Andrews MC, Duong CPM, Gopalakrishnan V, Iebba V, Chen WS, Derosa L, Khan MAW, Cogdill AP, White MG, Wong MC, Ferrere G, Fluckiger A, Roberti MP, Opolon P, Alou MT, Yonekura S, Roh W, Spencer CN, Curbelo IF, Vence L, Reuben A, Johnson S, Arora R, Morad G, Lastrapes M, Baruch EN, Little L, Gumbs C, Cooper ZA, Prieto PA, Wani K, Lazar AJ, Tetzlaff MT, Hudgens CW, Callahan MK, Adamow M, Postow MA, Ariyan CE, Gaudreau PO, Nezi L, Raoult D, Mihalcioiu C, Elkrief A, Pezo RC, Haydu LE, Simon JM, Tawbi HA, McQuade J, Hwu P, Hwu WJ, Amaria RN, Burton EM, Woodman SE, Watowich S, Diab A, Patel SP, Glitza IC, Wong MK, Zhao L, Zhang J, Ajami NJ, Petrosino J, Jenq RR, Davies MA, Gershenwald JE, Futreal PA, Sharma P, Allison JP, Routy B, Zitvogel L, Wargo JA. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade. Nat Med. 2021 08; 27(8):1432-1441. PMID: 34239137.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Deng S, Ramos-Castaneda M, Velasco WV, Clowers MJ, Gutierrez BA, Noble O, Dong Y, Zarghooni M, Alvarado L, Caetano MS, Yang S, Ostrin EJ, Behrens C, Wistuba II, Stabile LP, Kadara H, Watowich SS, Moghaddam SJ. Interplay between estrogen and Stat3/NF-?B-driven immunomodulation in lung cancer. Carcinogenesis. 2020 11 13; 41(11):1529-1542. PMID: 32603404.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Zhou Y, Slone N, Chrisikos TT, Kyrysyuk O, Babcock RL, Medik YB, Li HS, Kleinerman ES, Watowich SS. Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells. J Immunother Cancer. 2020 04; 8(1). PMID: 32273347.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Wang J, Hasan F, Frey AC, Li HS, Park J, Pan K, Haymaker C, Bernatchez C, Lee DA, Watowich SS, Yee C. Histone Deacetylase Inhibitors and IL21 Cooperate to Reprogram Human Effector CD8+ T Cells to Memory T Cells. Cancer Immunol Res. 2020 06; 8(6):794-805. PMID: 32213626.
      Citations: 6     Fields:    Translation:HumansCells
    6. Chrisikos TT, Zhou Y, Li HS, Babcock RL, Wan X, Patel B, Newton K, Mancuso JJ, Watowich SS. STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer. Cancers (Basel). 2020 Jan 04; 12(1). PMID: 31947933.
      Citations: 4     
    7. Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC. Preventing abnormal NF-?B activation and autoimmunity by Otub1-mediated p100 stabilization. Cell Res. 2019 06; 29(6):474-485. PMID: 31086255.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    8. Chu F, Li HS, Liu X, Cao J, Ma W, Ma Y, Weng J, Zhu Z, Cheng X, Wang Z, Liu J, Jiang ZY, Luong AU, Peng W, Wang J, Balakrishnan K, Yee C, Dong C, Davis RE, Watowich SS, Neelapu SS. CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity. Leukemia. 2019 11; 33(11):2640-2653. PMID: 31028278.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    9. Zuo X, Deguchi Y, Xu W, Liu Y, Li HS, Wei D, Tian R, Chen W, Xu M, Yang Y, Gao S, Jaoude JC, Liu F, Chrieki SP, Moussalli MJ, Gagea M, Sebastian MM, Zheng X, Tan D, Broaddus R, Wang J, Ajami NJ, Swennes AG, Watowich SS, Shureiqi I. PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. Gastroenterology. 2019 07; 157(1):163-178. PMID: 30885780.
      Citations: 9     Fields:    Translation:AnimalsCells
    10. Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JPW, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined Inhibition of STAT3 and DNA Repair in Palbociclib-Resistant ER-Positive Breast Cancer. Clin Cancer Res. 2019 07 01; 25(13):3996-4013. PMID: 30867218.
      Citations: 29     Fields:    Translation:HumansCells
    11. Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S. Author Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019 02 15; 10(1):862. PMID: 30770835.
      Citations: 4     Fields:    
    12. Yan J, Zhao Q, Gabrusiewicz K, Kong LY, Xia X, Wang J, Ott M, Xu J, Davis RE, Huo L, Rao G, Sun SC, Watowich SS, Heimberger AB, Li S. FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019 01 25; 10(1):448. PMID: 30683885.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    13. Caetano MS, Hassane M, Van HT, Bugarin E, Cumpian AM, McDowell CL, Cavazos CG, Zhang H, Deng S, Diao L, Wang J, Evans SE, Behrens C, Wistuba II, Fuqua SAW, Lin H, Stabile LP, Watowich SS, Kadara H, Moghaddam SJ. Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer. Nat Commun. 2018 11 02; 9(1):4589. PMID: 30389925.
      Citations: 19     Fields:    Translation:AnimalsCells
    14. Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE. Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant. Front Cell Neurosci. 2018; 12:365. PMID: 30386211.
      Citations: 8     
    15. Nicholson SE, Watowich SS. Introduction to the Special Issue: The tumor microenvironment and molecular regulation of innate immune cells. Mol Immunol. 2019 06; 110:1-2. PMID: 30318379.
      Citations:    Fields:    Translation:HumansCells
    16. Chrisikos TT, Zhou Y, Slone N, Babcock R, Watowich SS, Li HS. Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer. Mol Immunol. 2019 06; 110:24-39. PMID: 29549977.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    17. Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2311-E2319. PMID: 29463696.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. Fan F, Wang R, Boulbes DR, Zhang H, Watowich SS, Xia L, Ye X, Bhattacharya R, Ellis LM. Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway. PLoS One. 2018; 13(1):e0190070. PMID: 29293549.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    19. Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY. MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Exp Hematol. 2017 12; 56:7-15. PMID: 28911907.
      Citations: 4     Fields:    Translation:AnimalsCells
    20. Xiao Y, Zou Q, Xie X, Liu T, Li HS, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy DE, Watowich SS, Sun SC. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med. 2017 05 01; 214(5):1493-1507. PMID: 28356390.
      Citations: 19     Fields:    Translation:AnimalsCells
    21. Ni L, Wang L, Yao C, Ni Z, Liu F, Gong C, Zhu X, Yan X, Watowich SS, Lee DA, Zhu S. The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3. Sci Rep. 2017 03 24; 7:45266. PMID: 28338101.
      Citations: 20     Fields:    Translation:HumansCells
    22. Li HS, Liu C, Xiao Y, Chu F, Liang X, Peng W, Hu J, Neelapu SS, Sun SC, Hwu P, Watowich SS. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal. 2016 09 27; 9(447):ra94. PMID: 27678219.
      Citations: 9     Fields:    Translation:AnimalsCells
    23. Hillmer EJ, Zhang H, Li HS, Watowich SS. STAT3 signaling in immunity. Cytokine Growth Factor Rev. 2016 10; 31:1-15. PMID: 27185365.
      Citations: 101     Fields:    Translation:HumansAnimals
    24. Caetano MS, Zhang H, Cumpian AM, Gong L, Unver N, Ostrin EJ, Daliri S, Chang SH, Ochoa CE, Hanash S, Behrens C, Wistuba II, Sternberg C, Kadara H, Ferreira CG, Watowich SS, Moghaddam SJ. IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer. Cancer Res. 2016 06 01; 76(11):3189-99. PMID: 27197187.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    25. Li HS, Jin J, Liang X, Matatall KA, Ma Y, Zhang H, Ullrich SE, King KY, Sun SC, Watowich SS. Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice. Eur J Haematol. 2016 Sep; 97(3):261-70. PMID: 26660446.
      Citations: 3     Fields:    Translation:AnimalsCells
    26. Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-? Production via the Generation of Reactive Oxygen Species. Cell Rep. 2015 Aug 18; 12(7):1120-32. PMID: 26257170.
      Citations: 19     Fields:    Translation:AnimalsCells
    27. Mao F, Xu M, Zuo X, Yu J, Xu W, Moussalli MJ, Elias E, Li HS, Watowich SS, Shureiqi I. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J. 2015 Jun; 29(6):2359-70. PMID: 25713055.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    28. Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun. 2014 Dec 15; 5:5798. PMID: 25503582.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    29. Li HS, Watowich SS. Innate immune regulation by STAT-mediated transcriptional mechanisms. Immunol Rev. 2014 Sep; 261(1):84-101. PMID: 25123278.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    30. Watowich SS. Microbial messaging to the marrow. Blood. 2014 Aug 28; 124(9):1379-80. PMID: 25170108.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Zhu S, Phatarpekar PV, Denman CJ, Senyukov VV, Somanchi SS, Nguyen-Jackson HT, Mace EM, Freeman AF, Watowich SS, Orange JS, Holland SM, Lee DA. Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation. Blood. 2014 Jul 17; 124(3):403-11. PMID: 24891320.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    32. Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol. 2014 Jun; 15(6):562-70. PMID: 24777531.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    33. Munoz J, Dhillon N, Janku F, Watowich SS, Hong DS. STAT3 inhibitors: finding a home in lymphoma and leukemia. Oncologist. 2014 May; 19(5):536-44. PMID: 24705981.
      Citations: 22     Fields:    Translation:HumansCells
    34. Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-?B pathway controls the production of type I interferons in antiviral innate immunity. Immunity. 2014 Mar 20; 40(3):342-54. PMID: 24656046.
      Citations: 45     Fields:    Translation:AnimalsCells
    35. Li HS, Watowich SS. Assessing the development of murine plasmacytoid dendritic cells in Peyer's patches using adoptive transfer of hematopoietic progenitors. J Vis Exp. 2014 Mar 17; (85). PMID: 24686788.
      Citations:    Fields:    Translation:AnimalsCells
    36. Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 Jul; 14(7):732-40. PMID: 23727894.
      Citations: 53     Fields:    Translation:AnimalsCells
    37. Li HS, Watowich SS. Diversification of dendritic cell subsets: Emerging roles for STAT proteins. JAKSTAT. 2013 Oct 01; 2(4):e25112. PMID: 24416644.
      Citations: 11     
    38. Li HS, Greeley N, Sugimoto N, Liu YJ, Watowich SS. miR-22 controls Irf8 mRNA abundance and murine dendritic cell development. PLoS One. 2012; 7(12):e52341. PMID: 23251709.
      Citations: 16     Fields:    Translation:AnimalsCells
    39. Liu C, Peng W, Xu C, Lou Y, Zhang M, Wargo JA, Chen JQ, Li HS, Watowich SS, Yang Y, Tompers Frederick D, Cooper ZA, Mbofung RM, Whittington M, Flaherty KT, Woodman SE, Davies MA, Radvanyi LG, Overwijk WW, Lizée G, Hwu P. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res. 2013 Jan 15; 19(2):393-403. PMID: 23204132.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    40. Li HS, Yang CY, Nallaparaju KC, Zhang H, Liu YJ, Goldrath AW, Watowich SS. The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood. 2012 Nov 22; 120(22):4363-73. PMID: 23033267.
      Citations: 41     Fields:    Translation:AnimalsCells
    41. Nguyen-Jackson HT, Li HS, Zhang H, Ohashi E, Watowich SS. G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils. J Leukoc Biol. 2012 Dec; 92(6):1215-25. PMID: 23024284.
      Citations: 9     Fields:    Translation:AnimalsCells
    42. Li HS, Watowich SS. A STATus report on DC development. J Leukoc Biol. 2012 Sep; 92(3):445-59. PMID: 22550127.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    43. Nurieva RI, Podd A, Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, Wang D. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem. 2012 Mar 30; 287(14):11234-9. PMID: 22318729.
      Citations: 113     Fields:    Translation:AnimalsCells
    44. Yang CY, Best JA, Knell J, Yang E, Sheridan AD, Jesionek AK, Li HS, Rivera RR, Lind KC, D'Cruz LM, Watowich SS, Murre C, Goldrath AW. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol. 2011 Nov 06; 12(12):1221-9. PMID: 22057289.
      Citations: 170     Fields:    Translation:AnimalsCells
    45. Watowich SS. The erythropoietin receptor: molecular structure and hematopoietic signaling pathways. J Investig Med. 2011 Oct; 59(7):1067-72. PMID: 21307776.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    46. Li HS, Gelbard A, Martinez GJ, Esashi E, Zhang H, Nguyen-Jackson H, Liu YJ, Overwijk WW, Watowich SS. Cell-intrinsic role for IFN-a-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood. 2011 Oct 06; 118(14):3879-89. PMID: 21828128.
      Citations: 29     Fields:    Translation:AnimalsCells
    47. Watowich SS, Liu YJ. Mechanisms regulating dendritic cell specification and development. Immunol Rev. 2010 Nov; 238(1):76-92. PMID: 20969586.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    48. Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ. Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling. Sci Signal. 2010 Aug 17; 3(135):ra62. PMID: 20716764.
      Citations: 76     Fields:    Translation:AnimalsCells
    49. Zhang H, Nguyen-Jackson H, Panopoulos AD, Li HS, Murray PJ, Watowich SS. STAT3 controls myeloid progenitor growth during emergency granulopoiesis. Blood. 2010 Oct 07; 116(14):2462-71. PMID: 20581311.
      Citations: 88     Fields:    Translation:AnimalsCells
    50. Nguyen-Jackson H, Panopoulos AD, Zhang H, Li HS, Watowich SS. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood. 2010 Apr 22; 115(16):3354-63. PMID: 20185584.
      Citations: 51     Fields:    Translation:AnimalsCells
    51. Hegde S, Ni S, He S, Yoon D, Feng GS, Watowich SS, Paulson RF, Hankey PA. Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation. Oncogene. 2009 Sep 24; 28(38):3349-59. PMID: 19581930.
      Citations: 22     Fields:    Translation:AnimalsCells
    52. Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS, Ma L, Watowich SS, Jetten AM, Tian Q, Dong C. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009 Apr 17; 30(4):576-87. PMID: 19362022.
      Citations: 517     Fields:    Translation:AnimalsCells
    53. Speiran K, Bailey DP, Fernando J, Macey M, Barnstein B, Kolawole M, Curley D, Watowich SS, Murray PJ, Oskeritzian C, Ryan JJ. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol. 2009 May; 85(5):826-36. PMID: 19228815.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    54. Yamazaki T, Yang XO, Chung Y, Fukunaga A, Nurieva R, Pappu B, Martin-Orozco N, Kang HS, Ma L, Panopoulos AD, Craig S, Watowich SS, Jetten AM, Tian Q, Dong C. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol. 2008 Dec 15; 181(12):8391-401. PMID: 19050256.
      Citations: 203     Fields:    Translation:AnimalsCells
    55. Esashi E, Watowich SS. Dendritic cells: transcriptional control of plasmacytoid dendritic cell development by E2-2. Immunol Cell Biol. 2009 Jan; 87(1):1-2. PMID: 19048021.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    56. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, Dong C. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity. 2008 Jul 18; 29(1):138-49. PMID: 18599325.
      Citations: 555     Fields:    Translation:AnimalsCells
    57. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008 Jul 18; 29(1):44-56. PMID: 18585065.
      Citations: 504     Fields:    Translation:AnimalsCells
    58. Panopoulos AD, Watowich SS. Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. Cytokine. 2008 Jun; 42(3):277-88. PMID: 18400509.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    59. Esashi E, Wang YH, Perng O, Qin XF, Liu YJ, Watowich SS. The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity. 2008 Apr; 28(4):509-20. PMID: 18342552.
      Citations: 95     Fields:    Translation:AnimalsCells
    60. Kennedy Norton S, Barnstein B, Brenzovich J, Bailey DP, Kashyap M, Speiran K, Ford J, Conrad D, Watowich S, Moralle MR, Kepley CL, Murray PJ, Ryan JJ. IL-10 suppresses mast cell IgE receptor expression and signaling in vitro and in vivo. J Immunol. 2008 Mar 01; 180(5):2848-54. PMID: 18292506.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    61. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008 Jan; 28(1):29-39. PMID: 18164222.
      Citations: 666     Fields:    Translation:AnimalsCells
    62. El Kasmi KC, Smith AM, Williams L, Neale G, Panopoulos AD, Panopolous A, Watowich SS, Häcker H, Foxwell BM, Murray PJ. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway. J Immunol. 2007 Dec 01; 179(11):7215-9. PMID: 18025162.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    63. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007 Jul 26; 448(7152):480-3. PMID: 17581589.
      Citations: 616     Fields:    Translation:AnimalsCells
    64. Kile BT, Panopoulos AD, Stirzaker RA, Hacking DF, Tahtamouni LH, Willson TA, Mielke LA, Henley KJ, Zhang JG, Wicks IP, Stevenson WS, Nurden P, Watowich SS, Justice MJ. Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia. Blood. 2007 Oct 01; 110(7):2371-80. PMID: 17515402.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    65. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem. 2007 Mar 30; 282(13):9358-9363. PMID: 17277312.
      Citations: 578     Fields:    Translation:AnimalsCells
    66. El Kasmi KC, Holst J, Coffre M, Mielke L, de Pauw A, Lhocine N, Smith AM, Rutschman R, Kaushal D, Shen Y, Suda T, Donnelly RP, Myers MG, Alexander W, Vignali DA, Watowich SS, Ernst M, Hilton DJ, Murray PJ. General nature of the STAT3-activated anti-inflammatory response. J Immunol. 2006 Dec 01; 177(11):7880-8. PMID: 17114459.
      Citations: 92     Fields:    Translation:AnimalsCells
    67. Panopoulos AD, Zhang L, Snow JW, Jones DM, Smith AM, El Kasmi KC, Liu F, Goldsmith MA, Link DC, Murray PJ, Watowich SS. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood. 2006 Dec 01; 108(12):3682-90. PMID: 16888100.
      Citations: 91     Fields:    Translation:AnimalsCells
    68. Trevino JG, Gray MJ, Nawrocki ST, Summy JM, Lesslie DP, Evans DB, Sawyer TK, Shakespeare WC, Watowich SS, Chiao PJ, McConkey DJ, Gallick GE. Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells. Angiogenesis. 2006; 9(2):101-10. PMID: 16871430.
      Citations: 21     Fields:    Translation:HumansCells
    69. Zhang L, Badgwell DB, Bevers JJ, Schlessinger K, Murray PJ, Levy DE, Watowich SS. IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem. 2006 Aug; 288(1-2):179-89. PMID: 16718380.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    70. Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC, Luo RZ. A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. Cancer Res. 2005 Aug 01; 65(15):6701-10. PMID: 16061651.
      Citations: 11     Fields:    Translation:HumansCells
    71. Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005 Apr 28; 24(19):3110-20. PMID: 15735682.
      Citations: 145     Fields:    Translation:HumansCells
    72. Butcher BA, Kim L, Panopoulos AD, Watowich SS, Murray PJ, Denkers EY. IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol. 2005 Mar 15; 174(6):3148-52. PMID: 15749841.
      Citations: 67     Fields:    Translation:AnimalsCells
    73. Wang L, Arcasoy MO, Watowich SS, Forget BG. Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. Exp Hematol. 2005 Mar; 33(3):308-17. PMID: 15730854.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    74. Paredes A, Weaver S, Watowich S, Chiu W. Structural biology of old world and new world alphaviruses. Arch Virol Suppl. 2005; (19):179-85. PMID: 16358426.
      Citations: 5     Fields:    Translation:AnimalsCells
    75. Pauleau AL, Rutschman R, Lang R, Pernis A, Watowich SS, Murray PJ. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol. 2004 Jun 15; 172(12):7565-73. PMID: 15187136.
      Citations: 108     Fields:    Translation:AnimalsCells
    76. Yoon D, Watowich SS. Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway. Exp Hematol. 2003 Dec; 31(12):1310-6. PMID: 14662339.
      Citations: 6     Fields:    Translation:AnimalsCells
    77. Sarna MK, Ingley E, Busfield SJ, Cull VS, Lepere W, McCarthy DJ, Wright MJ, Palmer GA, Chappell D, Sayer MS, Alexander WS, Hilton DJ, Starr R, Watowich SS, Bittorf T, Klinken SP, Tilbrook PA. Differential regulation of SOCS genes in normal and transformed erythroid cells. Oncogene. 2003 May 22; 22(21):3221-30. PMID: 12761492.
      Citations: 10     Fields:    Translation:AnimalsCells
    78. Panopoulos AD, Bartos D, Zhang L, Watowich SS. Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. J Biol Chem. 2002 May 24; 277(21):19001-7. PMID: 11889125.
      Citations: 21     Fields:    Translation:AnimalsCells
    79. Afrikanova I, Yeh E, Bartos D, Watowich SS, Longmore GD. Oncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion. Oncogene. 2002 Feb 14; 21(8):1272-84. PMID: 11850847.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    80. Kubatzky KF, Ruan W, Gurezka R, Cohen J, Ketteler R, Watowich SS, Neumann D, Langosch D, Klingmüller U. Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor. Curr Biol. 2001 Jan 23; 11(2):110-5. PMID: 11231127.
      Citations: 30     Fields:    Translation:AnimalsCells
    81. Watowich SS, Mikami A, Busche RA, Xie X, Pharr PN, Longmore GD. Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis: lack of specificity of stat signals during red blood cell development. J Interferon Cytokine Res. 2000 Dec; 20(12):1065-70. PMID: 11152572.
      Citations: 4     Fields:    Translation:AnimalsCells
    82. Wooten DK, Xie X, Bartos D, Busche RA, Longmore GD, Watowich SS. Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D. J Biol Chem. 2000 Aug 25; 275(34):26566-75. PMID: 10858439.
      Citations: 11     Fields:    Translation:AnimalsCells
    83. Cull V, Tilbrook PA, Adenan AS, Chappell D, Ingley E, Sarna MK, Palmer TN, Watowich SS, Klinken SP. Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo. Oncogene. 2000 Feb 17; 19(7):953-60. PMID: 10702804.
      Citations: 2     Fields:    Translation:AnimalsCells
    84. Watowich SS. Activation of erythropoietin signaling by receptor dimerization. Int J Biochem Cell Biol. 1999 Oct; 31(10):1075-88. PMID: 10582340.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    85. Watowich SS, Xie X, Klingmuller U, Kere J, Lindlof M, Berglund S, de la Chapelle A. Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state. Blood. 1999 Oct 01; 94(7):2530-2. PMID: 10498627.
      Citations: 14     Fields:    Translation:HumansCells
    86. Watowich SS, Liu KD, Xie X, Lai SY, Mikami A, Longmore GD, Goldsmith MA. Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail. J Biol Chem. 1999 Feb 26; 274(9):5415-21. PMID: 10026152.
      Citations: 10     Fields:    Translation:Cells
    87. Levin I, Cohen J, Supino-Rosin L, Yoshimura A, Watowich SS, Neumann D. Identification of a cytoplasmic motif in the erythropoietin receptor required for receptor internalization. FEBS Lett. 1998 May 08; 427(2):164-70. PMID: 9607304.
      Citations: 6     Fields:    Translation:AnimalsCells
    88. Tarr K, Watowich SS, Longmore GD. Cell surface organization of the erythropoietin receptor complex differs depending on its mode of activation. J Biol Chem. 1997 Apr 04; 272(14):9099-107. PMID: 9083037.
      Citations: 3     Fields:    Translation:AnimalsCells
    89. Hilton DJ, Watowich SS, Katz L, Lodish HF. Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J Biol Chem. 1996 Mar 01; 271(9):4699-708. PMID: 8617735.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    90. Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF. Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12:91-128. PMID: 8970723.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    91. Murray PJ, Watowich SS, Lodish HF, Young RA, Hilton DJ. Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions. Anal Biochem. 1995 Aug 10; 229(2):170-9. PMID: 7485969.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    92. Hilton DJ, Watowich SS, Murray PJ, Lodish HF. Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. Proc Natl Acad Sci U S A. 1995 Jan 03; 92(1):190-4. PMID: 7816815.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    93. Lodish HF, Hilton DJ, Klingmüller U, Watowich SS, Wu H. The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60:93-104. PMID: 8824381.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    94. Watowich SS, Hilton DJ, Lodish HF. Activation and inhibition of erythropoietin receptor function: role of receptor dimerization. Mol Cell Biol. 1994 Jun; 14(6):3535-49. PMID: 8196600.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    95. Longmore GD, Watowich SS, Hilton DJ, Lodish HF. The erythropoietin receptor: its role in hematopoiesis and myeloproliferative diseases. J Cell Biol. 1993 Dec; 123(6 Pt 1):1305-8. PMID: 8253831.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    96. Longmore G, Watowich S, Pharr P, Neumann D, Lodish H. Activation of the erythropoietin receptor and leukemia induction in mice. Leukemia. 1993 Aug; 7 Suppl 2:S113-6. PMID: 8361212.
      Citations:    Fields:    Translation:AnimalsCells
    97. Neumann D, Wikström L, Watowich SS, Lodish HF. Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes. J Biol Chem. 1993 Jun 25; 268(18):13639-49. PMID: 8514796.
      Citations: 21     Fields:    Translation:AnimalsCells
    98. Watowich SS, Yoshimura A, Longmore GD, Hilton DJ, Yoshimura Y, Lodish HF. Homodimerization and constitutive activation of the erythropoietin receptor. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2140-4. PMID: 1312714.
      Citations: 72     Fields:    Translation:AnimalsCells
    99. Ng DT, Watowich SS, Lamb RA. Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene. Mol Biol Cell. 1992 Feb; 3(2):143-55. PMID: 1550958.
      Citations: 22     Fields:    Translation:AnimalsCells
    100. Lodish HF, Hilton D, Longmore G, Watowich SS, Yoshimura A. The erythropoietin receptor: dimerization, activation, and tumorigenesis. Cold Spring Harb Symp Quant Biol. 1992; 57:95-106. PMID: 1339709.
      Citations: 2     Fields:    Translation:AnimalsCells
    101. Watowich SS, Morimoto RI, Lamb RA. Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. J Virol. 1991 Jul; 65(7):3590-7. PMID: 2041085.
      Citations: 28     Fields:    Translation:Cells
    102. Watowich SS, Morimoto RI. Complex regulation of heat shock- and glucose-responsive genes in human cells. Mol Cell Biol. 1988 Jan; 8(1):393-405. PMID: 3275876.
      Citations: 68     Fields:    Translation:HumansCells
    103. Signaling through the membrane-proximal region of the erythropoietin receptor supports 32D cell survival. Blood. 96.
    104. G-CSF receptor structure, function, and intracellular signal transduction. 83-105.
    105. Regulation of dendritic cell development by STATs. 169-186.
    106. Assessing the development of murine plasmacytoid dendritic cells in Peyer's patches using adoptive transfer of hematopoietic progenitors. Journal of Visualized Experiments.
    107. Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages (DOI. Immunity. 29:318.
    108. Cutting edge. Journal of Immunology. 180:3612.
    109. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species. Cell Reports. 12:1120-1132.
    110. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Science Signaling. 9.
    111. IL6 blockade reprograms the lung tumor microenvironment to limit the development and progression of K-ras-mutant lung cancer. Cancer Research. 76:3189-3199.
    112. STAT3 signaling in immunity. Cytokine and Growth Factor Reviews.
    WATOWICH's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (520)
    Explore
    _
    Co-Authors (81)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _