SHELDON CHEN

TitleAssociate Professor
InstitutionMD Anderson
DepartmentEmergency Medicine
Address1515 Holcombe Blvd.
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Martínez-García C, Izquierdo-Lahuerta A, Vivas Y, Velasco I, Yeo TK, Chen S, Medina-Gomez G. Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes. PLoS One. 2015; 10(11):e0142291. PMID: 26545114.
      Citations: 12     Fields:    Translation:AnimalsCells
    2. Chung CH, Fan J, Lee EY, Kang JS, Lee SJ, Pyagay PE, Khoury CC, Yeo TK, Khayat MF, Wang A, Chen S. Effects of Tumor Necrosis Factor-a on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy. Nephron Extra. 2015 Jan-Apr; 5(1):1-18. PMID: 25852733.
      Citations:    
    3. Chen S. Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. J Am Soc Nephrol. 2013 May; 24(6):877-88. PMID: 23704286.
      Citations: 31     Fields:    Translation:Humans
    4. Khoury CC, Khayat MF, Yeo TK, Pyagay PE, Wang A, Asuncion AM, Sharma K, Yu W, Chen S. Visualizing the mouse podocyte with multiphoton microscopy. Biochem Biophys Res Commun. 2012 Oct 26; 427(3):525-30. PMID: 23022193.
      Citations: 8     Fields:    Translation:AnimalsCells
    5. Kanwar YS, Sun L, Xie P, Liu FY, Chen S. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol. 2011; 6:395-423. PMID: 21261520.
      Citations: 199     Fields:    Translation:Humans
    6. Lee EY, Chung CH, Khoury CC, Yeo TK, Pyagay PE, Wang A, Chen S. The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-beta, increases podocyte motility and albumin permeability. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F85-94. PMID: 19420107.
      Citations: 42     Fields:    Translation:AnimalsCells
    7. Chen S, Ziyadeh FN. Vascular endothelial growth factor and diabetic nephropathy. Curr Diab Rep. 2008 Dec; 8(6):470-6. PMID: 18990304.
      Citations: 19     Fields:    Translation:HumansAnimals
    8. Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR. Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood). 2008 Jan; 233(1):4-11. PMID: 18156300.
      Citations: 188     Fields:    Translation:Cells
    9. Wang A, Ziyadeh FN, Lee EY, Pyagay PE, Sung SH, Sheardown SA, Laping NJ, Chen S. Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1657-65. PMID: 17804483.
      Citations: 55     Fields:    Translation:AnimalsCells
    10. Chen S, Jalandhara N, Batlle D. Evaluation and management of hyponatremia: an emerging role for vasopressin receptor antagonists. Nat Clin Pract Nephrol. 2007 Feb; 3(2):82-95. PMID: 17251996.
      Citations: 5     Fields:    Translation:Humans
    11. Cohen MP, Lautenslager GT, Hud E, Shea E, Wang A, Chen S, Shearman CW. Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F789-95. PMID: 17018845.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. Sung SH, Ziyadeh FN, Wang A, Pyagay PE, Kanwar YS, Chen S. Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice. J Am Soc Nephrol. 2006 Nov; 17(11):3093-104. PMID: 16988063.
      Citations: 71     Fields:    Translation:Animals
    13. Wysocki J, Ye M, Soler MJ, Gurley SB, Xiao HD, Bernstein KE, Coffman TM, Chen S, Batlle D. ACE and ACE2 activity in diabetic mice. Diabetes. 2006 Jul; 55(7):2132-9. PMID: 16804085.
      Citations: 83     Fields:    Translation:AnimalsCells
    14. Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR. HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced "inside-out" signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F995-1004. PMID: 16774905.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Cohen MP, Ziyadeh FN, Chen S. Amadori-modified glycated serum proteins and accelerated atherosclerosis in diabetes: pathogenic and therapeutic implications. J Lab Clin Med. 2006 May; 147(5):211-9. PMID: 16697768.
      Citations: 11     Fields:    Translation:HumansCells
    16. Cohen MP, Chen S, Ziyadeh FN, Shea E, Hud EA, Lautenslager GT, Shearman CW. Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy. Kidney Int. 2005 Oct; 68(4):1554-61. PMID: 16164632.
      Citations: 14     Fields:    Translation:Animals
    17. Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes. 2005 Jun; 54(6):1626-34. PMID: 15919782.
      Citations: 175     Fields:    Translation:HumansAnimals
    18. Chen S, Lee JS, Iglesias-de la Cruz MC, Wang A, Izquierdo-Lahuerta A, Gandhi NK, Danesh FR, Wolf G, Ziyadeh FN. Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy. Nephrol Dial Transplant. 2005 Jul; 20(7):1320-8. PMID: 15840669.
      Citations: 29     Fields:    Translation:AnimalsCells
    19. Chen S, Kasama Y, Lee JS, Jim B, Marin M, Ziyadeh FN. Podocyte-derived vascular endothelial growth factor mediates the stimulation of alpha3(IV) collagen production by transforming growth factor-beta1 in mouse podocytes. Diabetes. 2004 Nov; 53(11):2939-49. PMID: 15504975.
      Citations: 31     Fields:    Translation:AnimalsCells
    20. Chen S, Hoffman BB, Lee JS, Kasama Y, Jim B, Kopp JB, Ziyadeh FN. Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose. Kidney Int. 2004 Apr; 65(4):1191-204. PMID: 15086458.
      Citations: 12     Fields:    Translation:AnimalsCells
    21. Chen S, Jim B, Ziyadeh FN. Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up. Semin Nephrol. 2003 Nov; 23(6):532-43. PMID: 14631561.
      Citations: 74     Fields:    Translation:HumansAnimals
    22. Cohen MP, Shea E, Chen S, Shearman CW. Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells. J Lab Clin Med. 2003 Apr; 141(4):242-9. PMID: 12677169.
      Citations: 26     Fields:    Translation:AnimalsCells
    23. Chen S, Iglesias-de la Cruz MC, Jim B, Hong SW, Isono M, Ziyadeh FN. Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice. Biochem Biophys Res Commun. 2003 Jan 03; 300(1):16-22. PMID: 12480514.
      Citations: 39     Fields:    Translation:HumansAnimals
    24. Isono M, Chen S, Hong SW, Iglesias-de la Cruz MC, Ziyadeh FN. Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells. Biochem Biophys Res Commun. 2002 Sep 06; 296(5):1356-65. PMID: 12207925.
      Citations: 41     Fields:    Translation:AnimalsCells
    25. Iglesias-de la Cruz MC, Ziyadeh FN, Isono M, Kouahou M, Han DC, Kalluri R, Mundel P, Chen S. Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int. 2002 Sep; 62(3):901-13. PMID: 12164872.
      Citations: 50     Fields:    Translation:AnimalsCells
    26. Cohen MP, Ziyadeh FN, Hong SW, Shearman CW, Hud E, Lautenslager GT, Iglesias-de la Cruz MC, Chen S. Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta1. Kidney Int. 2002 Jun; 61(6):2025-32. PMID: 12028443.
      Citations: 4     Fields:    Translation:Animals
    27. Wolf G, Chen S, Han DC, Ziyadeh FN. Leptin and renal disease. Am J Kidney Dis. 2002 Jan; 39(1):1-11. PMID: 11774095.
      Citations: 45     Fields:    Translation:HumansAnimals
    28. Pathophysiology of Diabetic Nephropathy. 151-162.
    29. Renal lipotoxicity-associated inflammation and insulin resistance affects actin cytoskeleton organization in podocytes. PLoS One. 10.
    30. Erratum. Nature Clinical Practice Nephrology. 3:233.
    31. Involvement of the transforming growth factor-β system in the pathogenesis of diabetic nephropathy. Clinical and Experimental Nephrology. 6:125-129.
    32. Pathophysiology and Pathogenesis of Diabetic Nephropathy. 2605-2632.
    33. Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders. 2477-2511.
    34. Abnormalities in signaling pathways in diabetic nephropathy. Expert Review of Endocrinology and Metabolism. 5:51-64.
    35. Effects of tumor necrosis factor-α on podocyte expression of monocyte chemoattractant protein-1 and in diabetic nephropathy. Nephron Extra. 5:1-18.
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