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SHAO-CONG SUN

TitleProfessor
InstitutionMD Anderson
DepartmentImmunology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming. Nat Immunol. 2019 07; 20(7):879-889. PMID: 31182807.
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    2. Li Y, Yang JY, Xie X, Jie Z, Zhang L, Shi J, Lin D, Gu M, Zhou X, Li HS, Watowich SS, Jain A, Yun Jung S, Qin J, Cheng X, Sun SC. Preventing abnormal NF-?B activation and autoimmunity by Otub1-mediated p100 stabilization. Cell Res. 2019 Jun; 29(6):474-485. PMID: 31086255.
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    3. Xie X, Jin J, Zhu L, Jie Z, Li Y, Zhao B, Cheng X, Li P, Sun SC. Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction. Cell Biosci. 2019; 9:5. PMID: 30622699.
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    4. Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, Sun SC. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nat Immunol. 2018 11; 19(11):1224-1235. PMID: 30250187.
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    5. Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, Shi J, Zhao S, Zhang B, Cheng X, Sun SC. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018 07 18; 9(1):2812. PMID: 30022064.
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    6. Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep. 2018 Apr 17; 23(3):823-837. PMID: 29669287.
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    7. Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, Lozano G, Chiao P, Maitra A, Leach SD, Kolls JK, Vilar E, Wang TC, Bailey JM, McAllister F. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. 2018 07; 155(1):210-223.e3. PMID: 29604293.
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    8. Yang J, Zhang S, Zhang L, Xie X, Wang H, Jie Z, Gu M, Yang JY, Cheng X, Sun SC. Lymphatic endothelial cells regulate B-cell homing to lymph nodes via a NIK-dependent mechanism. Cell Mol Immunol. 2019 Feb; 16(2):165-177. PMID: 29503445.
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    9. Zhang H, Li HS, Hillmer EJ, Zhao Y, Chrisikos TT, Hu H, Wu X, Thompson EJ, Clise-Dwyer K, Millerchip KA, Wei Y, Puebla-Osorio N, Kaushik S, Santos MA, Wang B, Garcia-Manero G, Wang J, Sun SC, Watowich SS. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2311-E2319. PMID: 29463696.
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    10. Liu T, Zhang L, Joo D, Sun SC. NF-?B signaling in inflammation. Signal Transduct Target Ther. 2017; 2. PMID: 29158945.
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    11. Sun SC. The non-canonical NF-?B pathway in immunity and inflammation. Nat Rev Immunol. 2017 Sep; 17(9):545-558. PMID: 28580957.
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    12. Li HS, Liu C, Xiao Y, Chu F, Liang X, Peng W, Hu J, Neelapu SS, Sun SC, Hwu P, Watowich SS. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal. 2016 09 27; 9(447):ra94. PMID: 27678219.
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    13. Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016 Mar 07; 213(3):399-414. PMID: 26903241.
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    14. Li HS, Jin J, Liang X, Matatall KA, Ma Y, Zhang H, Ullrich SE, King KY, Sun SC, Watowich SS. Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice. Eur J Haematol. 2016 Sep; 97(3):261-70. PMID: 26660446.
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    15. Zou Q, Jin J, Xiao Y, Zhou X, Hu H, Cheng X, Kazimi N, Ullrich SE, Sun SC. T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-? Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma. Cell Rep. 2015 Dec 22; 13(11):2470-2479. PMID: 26686633.
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    16. Morrow JK, Lin HK, Sun SC, Zhang S. Targeting ubiquitination for cancer therapies. Future Med Chem. 2015; 7(17):2333-50. PMID: 26630263.
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    17. Zou Q, Jin J, Xiao Y, Hu H, Zhou X, Jie Z, Xie X, Li JY, Cheng X, Sun SC. T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med. 2015 Jul 27; 212(8):1323-36. PMID: 26195727.
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    18. Xiao Y, Jin J, Zou Q, Hu H, Cheng X, Sun SC. Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS. Cell Biosci. 2015; 5:34. PMID: 26131354.
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    19. Romano S, Xiao Y, Nakaya M, D'Angelillo A, Chang M, Jin J, Hausch F, Masullo M, Feng X, Romano MF, Sun SC. FKBP51 employs both scaffold and isomerase functions to promote NF-?B activation in melanoma. Nucleic Acids Res. 2015 Aug 18; 43(14):6983-93. PMID: 26101251.
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    20. Chang JH, Hu H, Sun SC. Survival and maintenance of regulatory T cells require the kinase TAK1. Cell Mol Immunol. 2015 Sep; 12(5):572-9. PMID: 25891214.
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    21. Yu J, Zhou X, Chang M, Nakaya M, Chang JH, Xiao Y, Lindsey JW, Dorta-Estremera S, Cao W, Zal A, Zal T, Sun SC. Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nat Commun. 2015 Jan 21; 6:6074. PMID: 25606824.
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    22. Jin J, Xiao Y, Hu H, Zou Q, Li Y, Gao Y, Ge W, Cheng X, Sun SC. Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun. 2015 Jan 07; 6:5930. PMID: 25565375.
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    23. Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun. 2014 Dec 15; 5:5798. PMID: 25503582.
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    24. Xiao Y, Jin J, Chang M, Nakaya M, Hu H, Zou Q, Zhou X, Brittain GC, Cheng X, Sun SC. TPL2 mediates autoimmune inflammation through activation of the TAK1 axis of IL-17 signaling. J Exp Med. 2014 Jul 28; 211(8):1689-702. PMID: 24980047.
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    25. Yu J, Zhou X, Nakaya M, Jin W, Cheng X, Sun SC. T cell-intrinsic function of the noncanonical NF-?B pathway in the regulation of GM-CSF expression and experimental autoimmune encephalomyelitis pathogenesis. J Immunol. 2014 Jul 01; 193(1):422-30. PMID: 24899500.
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    26. Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 2014 May 15; 40(5):692-705. PMID: 24792914.
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    27. Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol. 2014 Jun; 15(6):562-70. PMID: 24777531.
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    28. Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-?B pathway controls the production of type I interferons in antiviral innate immunity. Immunity. 2014 Mar 20; 40(3):342-54. PMID: 24656046.
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    29. Chang JH, Hu H, Jin J, Puebla-Osorio N, Xiao Y, Gilbert BE, Brink R, Ullrich SE, Sun SC. TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med. 2014 Jan 13; 211(1):137-51. PMID: 24378539.
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    30. Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X. Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKß signaling cascade. Sci Signal. 2013 Dec 17; 6(306):ra110. PMID: 24345681.
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    31. Wu CF, Liu S, Lee YC, Wang R, Sun S, Yin F, Bornmann WG, Yu-Lee LY, Gallick GE, Zhang W, Lin SH, Kuang J. RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B. Oncogene. 2014 May 01; 33(18):2385-94. PMID: 23708659.
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    32. Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci Signal. 2013 May 14; 6(275):ra35. PMID: 23674823.
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    33. Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen Ø, Wang X, Brink R, Cheng X, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nat Med. 2013 May; 19(5):595-602. PMID: 23603814.
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    34. Sun SC, Chang JH, Jin J. Regulation of nuclear factor-?B in autoimmunity. Trends Immunol. 2013 Jun; 34(6):282-9. PMID: 23434408.
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    35. Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-?B activation through deubiquitination of TRAF3. Nature. 2013 Feb 21; 494(7437):371-4. PMID: 23334419.
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    36. Zhou XF, Yu J, Chang M, Zhang M, Zhou D, Cammas F, Sun SC. TRIM28 mediates chromatin modifications at the TCRa enhancer and regulates the development of T and natural killer T cells. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):20083-8. PMID: 23169648.
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    37. Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC. The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-?B signaling. Nat Immunol. 2012 Nov; 13(11):1101-9. PMID: 23023393.
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    38. Ren T, Dong W, Takahashi Y, Xiang D, Yuan Y, Liu X, Loughran TP, Sun SC, Wang HG, Cheng H. HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy. J Biol Chem. 2012 Oct 05; 287(41):34683-93. PMID: 22891252.
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    39. Cheng H, Ren T, Sun SC. New insight into the oncogenic mechanism of the retroviral oncoprotein Tax. Protein Cell. 2012 Aug; 3(8):581-9. PMID: 22865346.
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    40. Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol. 2012 Jul 15; 189(2):786-92. PMID: 22706086.
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    41. Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC. Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 2012 May; 13(5):481-90. PMID: 22484734.
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    42. Sun SC. The noncanonical NF-?B pathway. Immunol Rev. 2012 Mar; 246(1):125-40. PMID: 22435551.
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    43. Jin W, Chang M, Sun SC. Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell Mol Immunol. 2012 Mar; 9(2):113-22. PMID: 22307041.
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    44. Sun SC. Immune receptor signaling: from ubiquitination to NF-?B activation. Cell Mol Immunol. 2012 Mar; 9(2):97-8. PMID: 22231553.
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    45. Zhang M, Lee AJ, Wu X, Sun SC. Regulation of antiviral innate immunity by deubiquitinase CYLD. Cell Mol Immunol. 2011 Nov; 8(6):502-4. PMID: 21946435.
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    46. Chiou SH, Shahi P, Wagner RT, Hu H, Lapteva N, Seethammagari M, Sun SC, Levitt JM, Spencer DM. The E3 ligase c-Cbl regulates dendritic cell activation. EMBO Rep. 2011 Sep 01; 12(9):971-9. PMID: 21799517.
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    47. Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P, Rabinovich BA, Hwu P, Sun SC. The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol. 2011 Aug 28; 12(10):1002-9. PMID: 21874024.
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    48. Wu X, Zhang M, Sun SC. Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax. Cell Biosci. 2011 Aug 08; 1:27. PMID: 21824392.
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    49. Hu H, Wu X, Jin W, Chang M, Cheng X, Sun SC. Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12827-32. PMID: 21768353.
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    50. Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-?B p50. Sci Signal. 2011 Feb 22; 4(161):ra11. PMID: 21343618.
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    51. Sun SC, Liu ZG. A special issue on NF-?B signaling and function. Cell Res. 2011 Jan; 21(1):1-2. PMID: 21196938.
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    52. Sun SC, Cesarman E. NF-?B as a target for oncogenic viruses. Curr Top Microbiol Immunol. 2011; 349:197-244. PMID: 20845110.
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    53. Sun SC. Non-canonical NF-?B signaling pathway. Cell Res. 2011 Jan; 21(1):71-85. PMID: 21173796.
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    54. Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Inglés-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, Mullighan CC, Levine RL, Rajewsky K, Aifantis I, Bigas A. The Notch/Hes1 pathway sustains NF-?B activation through CYLD repression in T cell leukemia. Cancer Cell. 2010 Sep 14; 18(3):268-81. PMID: 20832754.
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    55. Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15193-8. PMID: 20696914.
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    56. Sun SC. Controlling the fate of NIK: a central stage in noncanonical NF-kappaB signaling. Sci Signal. 2010 May 25; 3(123):pe18. PMID: 20501935.
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    57. Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28; 32(5):670-80. PMID: 20493730.
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    58. Lee AJ, Wu X, Cheng H, Zhou X, Cheng X, Sun SC. CARMA1 regulation of regulatory T cell development involves modulation of interleukin-2 receptor signaling. J Biol Chem. 2010 May 21; 285(21):15696-703. PMID: 20233721.
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    59. Lee AJ, Zhou X, Chang M, Hunzeker J, Bonneau RH, Zhou D, Sun SC. Regulation of natural killer T-cell development by deubiquitinase CYLD. EMBO J. 2010 May 05; 29(9):1600-12. PMID: 20224552.
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    60. Arima K, Watanabe N, Hanabuchi S, Chang M, Sun SC, Liu YJ. Distinct signal codes generate dendritic cell functional plasticity. Sci Signal. 2010 Jan 19; 3(105):ra4. PMID: 20086239.
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    61. Sun SC. CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ. 2010 Jan; 17(1):25-34. PMID: 19373246.
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    62. Tang H, Park S, Sun SC, Trumbly R, Ren G, Tsung E, Yeung KC. RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex. FEBS Lett. 2010 Feb 19; 584(4):662-8. PMID: 20043910.
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    63. Wu X, Yamamoto M, Akira S, Sun SC. Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20836-41. PMID: 19926860.
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    64. Fontenot D, He H, Hanabuchi S, Nehete PN, Zhang M, Chang M, Nehete B, Wang YH, Wang YH, Ma ZM, Lee HC, Ziegler SF, Courtney AN, Miller CJ, Sun SC, Liu YJ, Sastry KJ. TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16776-81. PMID: 19805372.
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    65. Chang M, Jin W, Sun SC. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol. 2009 Oct; 10(10):1089-95. PMID: 19734906.
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    66. Jin W, Zhou XF, Yu J, Cheng X, Sun SC. Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK. Blood. 2009 Jun 25; 113(26):6603-10. PMID: 19411637.
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    67. Chang M, Lee AJ, Fitzpatrick L, Zhang M, Sun SC. NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation. J Immunol. 2009 Mar 01; 182(5):3131-8. PMID: 19234210.
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    68. Zhang M, Jin W, Zhou X, Yu J, Lee AJ, Sun SC. Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. Cell Signal. 2009 Apr; 21(4):559-66. PMID: 19159680.
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    69. Sun SC, Ley SC. New insights into NF-kappaB regulation and function. Trends Immunol. 2008 Oct; 29(10):469-78. PMID: 18775672.
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    70. Sun SC. Deubiquitylation and regulation of the immune response. Nat Rev Immunol. 2008 Jul; 8(7):501-11. PMID: 18535581.
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    71. Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC. Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem. 2008 Jul 04; 283(27):18621-6. PMID: 18467330.
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    72. Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest. 2008 May; 118(5):1858-66. PMID: 18382763.
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    73. Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M, Sun SC. Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell. 2007 Nov; 13(5):705-16. PMID: 17981138.
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    74. Reiley WW, Jin W, Lee AJ, Wright A, Wu X, Tewalt EF, Leonard TO, Norbury CC, Fitzpatrick L, Zhang M, Sun SC. Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med. 2007 Jun 11; 204(6):1475-85. PMID: 17548520.
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    75. Jin W, Reiley WR, Lee AJ, Wright A, Wu X, Zhang M, Sun SC. Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells. J Biol Chem. 2007 May 25; 282(21):15884-93. PMID: 17392286.
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    76. Wu X, Sun SC. Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK. EMBO Rep. 2007 May; 8(5):510-5. PMID: 17363973.
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    77. Harhaj NS, Sun SC, Harhaj EW. Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem. 2007 Feb 09; 282(6):4185-92. PMID: 17145747.
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    78. Babu G, Waterfield M, Chang M, Wu X, Sun SC. Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J Biol Chem. 2006 May 19; 281(20):14041-7. PMID: 16565081.
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    79. Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC, Sun SC. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol. 2006 Apr; 7(4):411-7. PMID: 16501569.
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    80. Babu GR, Jin W, Norman L, Waterfield M, Chang M, Wu X, Zhang M, Sun SC. Phosphorylation of NF-kappaB1/p105 by oncoprotein kinase Tpl2: implications for a novel mechanism of Tpl2 regulation. Biochim Biophys Acta. 2006 Feb; 1763(2):174-81. PMID: 16448710.
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    81. Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1146-59. PMID: 16306129.
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    82. Liang C, Zhang M, Sun SC. beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal. 2006 Aug; 18(8):1309-17. PMID: 16303288.
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    83. Sun SC, Yamaoka S. Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene. 2005 Sep 05; 24(39):5952-64. PMID: 16155602.
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    84. Reiley W, Zhang M, Wu X, Granger E, Sun SC. Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol. 2005 May; 25(10):3886-95. PMID: 15870263.
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    85. Harhaj EW, Harhaj NS, Grant C, Mostoller K, Alefantis T, Sun SC, Wigdahl B. Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway. Virology. 2005 Mar 01; 333(1):145-58. PMID: 15708600.
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    86. Morrison MD, Reiley W, Zhang M, Sun SC. An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway. J Biol Chem. 2005 Mar 18; 280(11):10018-24. PMID: 15644327.
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    87. Reiley W, Zhang M, Sun SC. Negative regulation of JNK signaling by the tumor suppressor CYLD. J Biol Chem. 2004 Dec 31; 279(53):55161-7. PMID: 15496400.
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    88. Waterfield M, Jin W, Reiley W, Zhang M, Sun SC. IkappaB kinase is an essential component of the Tpl2 signaling pathway. Mol Cell Biol. 2004 Jul; 24(13):6040-8. PMID: 15199157.
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    89. Xiao G, Fong A, Sun SC. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem. 2004 Jul 16; 279(29):30099-105. PMID: 15140882.
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    90. Liao G, Zhang M, Harhaj EW, Sun SC. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem. 2004 Jun 18; 279(25):26243-50. PMID: 15084608.
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    91. Sun SC, Xiao G. Deregulation of NF-kappaB and its upstream kinases in cancer. Cancer Metastasis Rev. 2003 Dec; 22(4):405-22. PMID: 12884915.
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    92. Liao G, Sun SC. Regulation of NF-kappaB2/p100 processing by its nuclear shuttling. Oncogene. 2003 Jul 31; 22(31):4868-74. PMID: 12894228.
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    93. Cvijic ME, Xiao G, Sun SC. Study of T-cell signaling by somatic cell mutagenesis and complementation cloning. J Immunol Methods. 2003 Jul; 278(1-2):293-304. PMID: 12957416.
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    94. Waterfield MR, Zhang M, Norman LP, Sun SC. NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol Cell. 2003 Mar; 11(3):685-94. PMID: 12667451.
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    95. Fong A, Zhang M, Neely J, Sun SC. S9, a 19 S proteasome subunit interacting with ubiquitinated NF-kappaB2/p100. J Biol Chem. 2002 Oct 25; 277(43):40697-702. PMID: 12185077.
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    96. Fong A, Sun SC. Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. J Biol Chem. 2002 Jun 21; 277(25):22111-4. PMID: 11994270.
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    97. Sun SY, Yue P, Chen X, Hong WK, Lotan R. The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells. Cancer Res. 2002 Apr 15; 62(8):2430-6. PMID: 11956107.
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    98. Sun SY. How much do we know about retinoid-regulated genes? Cancer Biol Ther. 2002 Jan-Feb; 1(1):28-30. PMID: 12197481.
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    99. Xiao G, Cvijic ME, Fong A, Harhaj EW, Uhlik MT, Waterfield M, Sun SC. Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J. 2001 Dec 03; 20(23):6805-15. PMID: 11726516.
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    100. Rivera-Walsh I, Waterfield M, Xiao G, Fong A, Sun SC. NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J Biol Chem. 2001 Nov 02; 276(44):40385-8. PMID: 11553609.
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    101. Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001 Aug 24; 293(5534):1495-9. PMID: 11520989.
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    102. Sun SY, Yue P, Kelloff GJ, Steele VE, Lippman SM, Hong WK, Lotan R. Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells. Cancer Epidemiol Biomarkers Prev. 2001 Jun; 10(6):595-601. PMID: 11401908.
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    103. Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell. 2001 Feb; 7(2):401-9. PMID: 11239468.
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    104. Sun SY, Yue P, Hong WK, Lotan R. Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells. Cancer Res. 2000 Dec 15; 60(24):7149-55. PMID: 11156424.
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    105. Xiao G, Harhaj EW, Sun SC. Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK. J Biol Chem. 2000 Nov 03; 275(44):34060-7. PMID: 10906125.
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    106. Sun SC, Harhaj EW, Xiao G, Good L. Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma. AIDS Res Hum Retroviruses. 2000 Nov 01; 16(16):1591-6. PMID: 11080796.
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    107. Xiao G, Sun SC. Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. Oncogene. 2000 Oct 26; 19(45):5198-203. PMID: 11064457.
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    108. Rivera-Walsh I, Cvijic ME, Xiao G, Sun SC. The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death. J Biol Chem. 2000 Aug 18; 275(33):25222-30. PMID: 10837465.
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    109. Xiao G, Sun SC. Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. J Biol Chem. 2000 Jul 14; 275(28):21081-5. PMID: 10887201.
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    110. Harhaj EW, Good L, Xiao G, Uhlik M, Cvijic ME, Rivera-Walsh I, Sun SC. Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein. Oncogene. 2000 Mar 09; 19(11):1448-56. PMID: 10723136.
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    111. Sun SC, Ballard DW. Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases. Oncogene. 1999 Nov 22; 18(49):6948-58. PMID: 10602469.
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    112. Sherman MB, Jakana J, Sun S, Matsudaira P, Chiu W, Schmid MF. The three-dimensional structure of the Limulus acrosomal process: a dynamic actin bundle. J Mol Biol. 1999 Nov 19; 294(1):139-49. PMID: 10556034.
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    113. Harhaj EW, Sun SC. Regulation of RelA subcellular localization by a putative nuclear export signal and p50. Mol Cell Biol. 1999 Oct; 19(10):7088-95. PMID: 10490645.
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    114. Harhaj EW, Sun SC. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem. 1999 Aug 13; 274(33):22911-4. PMID: 10438454.
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    115. Lamberti A, Romano MF, Agosti V, Garbi C, Sun SC, Bond HM, Bonelli P, Turco MC, Venuta S. Regulation of cell survival in CD95-induced T cell apoptosis: role of NF-kappa B/Rel transcription factors. Apoptosis. 1999 Jun; 4(3):179-86. PMID: 14634280.
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    116. Sun SC, Maggirwar SB, Harhaj EW, Uhlik M. Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells. Oncogene. 1999 Feb 18; 18(7):1401-9. PMID: 10050877.
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    117. Harhaj EW, Good L, Xiao G, Sun SC. Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. Oncogene. 1999 Feb 11; 18(6):1341-9. PMID: 10022816.
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    118. Harhaj EW, Sun SC. IkappaB kinases serve as a target of CD28 signaling. J Biol Chem. 1998 Sep 25; 273(39):25185-90. PMID: 9737979.
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    119. Rivera I, Harhaj EW, Sun SC. Involvement of NF-AT in type I human T-cell leukemia virus Tax-mediated Fas ligand promoter transactivation. J Biol Chem. 1998 Aug 28; 273(35):22382-8. PMID: 9712859.
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    120. Zhang MY, Harhaj EW, Bell L, Sun SC, Miller BA. Bcl-3 expression and nuclear translocation are induced by granulocyte-macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors. Blood. 1998 Aug 15; 92(4):1225-34. PMID: 9694711.
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    121. Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem. 1998 Aug 14; 273(33):21132-6. PMID: 9694868.
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    122. Zhang MY, Sun SC, Bell L, Miller BA. NF-kappaB transcription factors are involved in normal erythropoiesis. Blood. 1998 Jun 01; 91(11):4136-44. PMID: 9596659.
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    123. Sherman MB, Jakana J, Sun S, Matsudaira P, Chiu W, Schmid MF. A strategy for electron tomographic data collection and crystallographic reconstruction of biological bundles. J Struct Biol. 1997 Dec; 120(3):245-56. PMID: 9441930.
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    124. Turco MC, Romano MF, Lamberti A, Petrella A, Bisogni R, Sun SC, Ferrone S, Bonelli P, Cerra M, Venuta S. Induction of nuclear factor kappa B/Rel nuclear activity in human peripheral blood T lymphocytes by anti-HLA class I monoclonal antibodies. Tissue Antigens. 1997 Jul; 50(1):1-7. PMID: 9243748.
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    125. Chen F, Lu Y, Kuhn DC, Maki M, Shi X, Sun SC, Demers LM. Calpain contributes to silica-induced I kappa B-alpha degradation and nuclear factor-kappa B activation. Arch Biochem Biophys. 1997 Jun 15; 342(2):383-8. PMID: 9186501.
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    126. Maggirwar SB, Harhaj EW, Sun SC. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors. Mol Cell Biol. 1997 May; 17(5):2605-14. PMID: 9111330.
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    127. Chen F, Sun S, Kuhn DC, Gaydos LJ, Shi X, Lu Y, Demers LM. Involvement of NF-kappaB in silica-induced cyclooxygenase II gene expression in rat alveolar macrophages. Am J Physiol. 1997 Apr; 272(4 Pt 1):L779-86. PMID: 9142954.
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    128. Harhaj EW, Sun SC. The serine/threonine phosphatase inhibitor calyculin A induces rapid degradation of IkappaBbeta. Requirement of both the N- and C-terminal sequences. J Biol Chem. 1997 Feb 28; 272(9):5409-12. PMID: 9038140.
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    129. Chen F, Sun S, Kuhn DC, Lu Y, Gaydos LJ, Shi X, Demers LM. Tetrandrine inhibits signal-induced NF-kappa B activation in rat alveolar macrophages. Biochem Biophys Res Commun. 1997 Feb 03; 231(1):99-102. PMID: 9070227.
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    130. Good L, Maggirwar SB, Harhaj EW, Sun SC. Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells. J Biol Chem. 1997 Jan 17; 272(3):1425-8. PMID: 8999806.
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    131. Harhaj EW, Maggirwar SB, Good L, Sun SC. CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers. Mol Cell Biol. 1996 Dec; 16(12):6736-43. PMID: 8943328.
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    132. Mandal M, Maggirwar SB, Sharma N, Kaufmann SH, Sun SC, Kumar R. Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. J Biol Chem. 1996 Nov 29; 271(48):30354-9. PMID: 8939996.
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    133. Good L, Maggirwar SB, Sun SC. Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element. EMBO J. 1996 Jul 15; 15(14):3744-50. PMID: 8670878.
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    134. Harhaj EW, Maggirwar SB, Sun SC. Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells. Oncogene. 1996 Jun 06; 12(11):2385-92. PMID: 8649779.
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    135. Good LF, Maggirwar SB, Kealiher A, Uhlik M, Sun SC. Multiple structural domains within I kappa B alpha are required for its inducible degradation by both cytokines and phosphatase inhibitors. Biochem Biophys Res Commun. 1996 Jun 05; 223(1):123-8. PMID: 8660357.
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    136. Good L, Sun SC. Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta. J Virol. 1996 May; 70(5):2730-5. PMID: 8627746.
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    137. Sun S, Elwood J, Greene WC. Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradation. Mol Cell Biol. 1996 Mar; 16(3):1058-65. PMID: 8622650.
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    138. Harhaj E, Blaney J, Millhouse S, Sun SC. Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR. Virology. 1996 Feb 01; 216(1):284-7. PMID: 8615004.
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    139. Chen F, Kuhn DC, Sun SC, Gaydos LJ, Demers LM. Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages. Biochem Biophys Res Commun. 1995 Sep 25; 214(3):839-46. PMID: 7575553.
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    140. Chen F, Sun SC, Kuh DC, Gaydos LJ, Demers LM. Essential role of NF-kappa B activation in silica-induced inflammatory mediator production in macrophages. Biochem Biophys Res Commun. 1995 Sep 25; 214(3):985-92. PMID: 7575573.
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    141. Maggirwar SB, Harhaj E, Sun SC. Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor. Oncogene. 1995 Sep 07; 11(5):993-8. PMID: 7675460.
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    142. Sun SC, Maggirwar SB, Harhaj E. Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites. J Biol Chem. 1995 Aug 04; 270(31):18347-51. PMID: 7629157.
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    143. Sun SC, Faye I. Transcription of immune genes in the giant silkmoth, Hyalophora cecropia, is augmented by H2O2 and diminished by thiol reagents. Eur J Biochem. 1995 Jul 01; 231(1):93-8. PMID: 7628488.
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    144. Lindström-Dinnetz I, Sun SC, Faye I. Structure and expression of Hemolin, an insect member of the immunoglobulin gene superfamily. Eur J Biochem. 1995 Jun 15; 230(3):920-5. PMID: 7601154.
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    145. Sun SC, Elwood J, Béraud C, Greene WC. Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol Cell Biol. 1994 Nov; 14(11):7377-84. PMID: 7935451.
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    146. Sun SC, Ganchi PA, Béraud C, Ballard DW, Greene WC. Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1346-50. PMID: 8108414.
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    147. Béraud C, Sun SC, Ganchi P, Ballard DW, Greene WC. Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency. Mol Cell Biol. 1994 Feb; 14(2):1374-82. PMID: 8289813.
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    148. Ganchi PA, Sun SC, Greene WC, Ballard DW. A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization. Mol Cell Biol. 1993 Dec; 13(12):7826-35. PMID: 8246997.
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    149. Engström Y, Kadalayil L, Sun SC, Samakovlis C, Hultmark D, Faye I. kappa B-like motifs regulate the induction of immune genes in Drosophila. J Mol Biol. 1993 Jul 20; 232(2):327-33. PMID: 8345514.
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    150. Schmidt O, Faye I, Lindström-Dinnetz I, Sun SC. Specific immune recognition of insect hemolin. Dev Comp Immunol. 1993 May-Jun; 17(3):195-200. PMID: 8325433.
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    151. Sun SC, Ganchi PA, Ballard DW, Greene WC. NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science. 1993 Mar 26; 259(5103):1912-5. PMID: 8096091.
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    152. Doerre S, Sista P, Sun SC, Ballard DW, Greene WC. The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus. Proc Natl Acad Sci U S A. 1993 Feb 01; 90(3):1023-7. PMID: 8430069.
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    153. Ganchi PA, Sun SC, Greene WC, Ballard DW. I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol Biol Cell. 1992 Dec; 3(12):1339-52. PMID: 1493333.
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    154. Sun SC, Faye I. Affinity purification and characterization of CIF, an insect immunoresponsive factor with NF-kappa B-like properties. Comp Biochem Physiol B. 1992 Sep; 103(1):225-33. PMID: 1451434.
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    155. Sun SC, Faye I. Cecropia immunoresponsive factor, an insect immunoresponsive factor with DNA-binding properties similar to nuclear-factor kappa B. Eur J Biochem. 1992 Mar 01; 204(2):885-92. PMID: 1541299.
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    156. Sun SC, Asling B, Faye I. Organization and expression of the immunoresponsive lysozyme gene in the giant silk moth, Hyalophora cecropia. J Biol Chem. 1991 Apr 05; 266(10):6644-9. PMID: 2007608.
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    157. Sun SC, Lindström I, Lee JY, Faye I. Structure and expression of the attacin genes in Hyalophora cecropia. Eur J Biochem. 1991 Feb 26; 196(1):247-54. PMID: 2001705.
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    158. Sun SC, Lindström I, Boman HG, Faye I, Schmidt O. Hemolin: an insect-immune protein belonging to the immunoglobulin superfamily. Science. 1990 Dec 21; 250(4988):1729-32. PMID: 2270488.
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    159. Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Nature Immunology.
    160. NF-κB as a target for oncogenic viruses. 197-244.
    161. Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nature Communications. 6.
    162. TPL2 mediates IL-17R signaling in neuroinflammation. Oncotarget. 6:21789-21790.
    163. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Science Signaling. 9.
    164. Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses. Scientific Reports. 6.
    165. Peli1 negatively regulates type I interferon induction and antiviral immunity in the CNS. Cell and Bioscience. 5.
    166. Erratum. Journal of Biological Chemistry. 276:6880.
    167. Survival and maintenance of regulatory T cells require the kinase TAK1. Cellular and Molecular Immunology. 12:572-579.
    168. Hemolin, an insect immune protein belonging to the immunoglobulin superfamily. Developmental and Comparative Immunology. 15.
    169. T Cell Intrinsic USP15 Deficiency Promotes Excessive IFN-γ Production and an Immunosuppressive Tumor Microenvironment in MCA-Induced Fibrosarcoma. Cell Reports. 13:2470-2479.
    170. Ubiquitin signaling in immune responses. Cell Research. 26:457-483.
    171. Targeting ubiquitination for cancer therapies. Future Medicinal Chemistry. 7:2333-2350.
    172. TCR signaling to NF-κB and mTORC1. Molecular Immunology. 68:546-557.
    173. Regulation of the interleukin-2 CD28 responsive element by NF-ATp and NF-κB/Rel. FASEB Journal. 11.
    174. Targeting signaling factors for degradation, an emerging mechanism for TRAF functions. Immunological Reviews. 266:56-71.
    175. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. Journal of Experimental Medicine. 213:399-414.
    176. Cell and Bioscience. 5.
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