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SAMUEL SHELBURNE

TitleAssociate Professor
InstitutionMD Anderson
DepartmentInfectious Diseases, Infection Control, and Employee Health
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    K08AI064564     (SHELBURNE, SAMUEL A)Jul 1, 2006 - May 31, 2011
    NIH/NIAID
    Analysis Of Group A Streptococcus-Saliva Interaction
    Role: Principal Investigator

    R01AI089891     (SHELBURNE, SAMUEL A)Jul 15, 2011 - Jun 30, 2016
    NIH/NIAID
    Contribution of catabolite control protein A to group A streptococcal virulence
    Role: Principal Investigator

    R01AI125292     (SHELBURNE, SAMUEL A)Jan 16, 2017 - Dec 31, 2021
    NIH/NIAID
    Role of response regulator phosphorylation in group A streptococcal pathogenesis
    Role: Principal Investigator

    R21AI132920     (SHELBURNE, SAMUEL A)May 14, 2018 - Apr 30, 2020
    NIH/NIAID
    Novel mechanisms of emergence of hypervirulent group A Streptococcus
    Role: Principal Investigator

    R21AI142126     (SHELBURNE, SAMUEL A)Dec 6, 2018 - Nov 30, 2020
    NIH/NIAID
    Impact of a novel emm-enn gene fusion event on epidemic behavior of group A streptococcus
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Flores AR, Shelburne SA. Toward an understanding of group A streptococcal transmission dynamics using national-level surveillance. Clin Infect Dis. 2019 Aug 13. PMID: 31408107.
      View in: PubMed
    2. Muñoz NM, Minhaj AA, Dupuis CJ, Ensor JE, Golardi N, Jaso JM, Dixon KA, Figueira TA, Galloway-Peña JR, Hill L, Shelburne SA, Tam AL. What Are the Effects of Irreversible Electroporation on a Staphylococcus aureus Rabbit Model of Osteomyelitis? Clin Orthop Relat Res. 2019 Aug 05. PMID: 31393339.
      View in: PubMed
    3. Galloway-Peña JR, Peterson CB, Malik F, Sahasrabhojane PV, Shah DP, Brumlow CE, Carlin LG, Chemaly RF, Im JS, Rondon G, Felix E, Veillon L, Lorenzi PL, Alousi AM, Jenq RR, Kontoyiannis DP, Shpall EJ, Shelburne SA, Okhuysen PC. Fecal Microbiome, Metabolites, and Stem Cell Transplant Outcomes: A Single-Center Pilot Study. Open Forum Infect Dis. 2019 May; 6(5):ofz173. PMID: 31065565.
      View in: PubMed
    4. Tran TT, Mishra NN, Seepersaud R, Diaz L, Rios R, Dinh AQ, Garcia-de-la-Maria C, Rybak MJ, Miro JM, Shelburne SA, Sullam PM, Bayer AS, Arias CA. Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 Feb; 63(2). PMID: 30509945.
      View in: PubMed
    5. Benanti GE, Brown ART, Shigle TL, Tarrand JJ, Bhatti MM, McDaneld PM, Shelburne SA, Aitken SL. Carbapenem versus Cefepime or Piperacillin-Tazobactam for Empiric Treatment of Bacteremia Due to Extended-Spectrum-ß-Lactamase-Producing Escherichia coli in Patients with Hematologic Malignancy. Antimicrob Agents Chemother. 2019 Feb; 63(2). PMID: 30509935.
      View in: PubMed
    6. Galloway-Peña J, DebRoy S, Brumlow C, Li X, Tran TT, Horstmann N, Yao H, Chen K, Wang F, Pan BF, Hawke DH, Thompson EJ, Arias CA, Fowler VG, Bhatti MM, Kalia A, Flores AR, Shelburne SA. Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface. PLoS One. 2018; 13(12):e0207897. PMID: 30517150.
      View in: PubMed
    7. DebRoy S, Li X, Kalia A, Galloway-Pena J, Shah BJ, Fowler VG, Flores AR, Shelburne SA. Identification of a chimeric emm gene and novel emm pattern in currently circulating strains of emm4 Group A Streptococcus. Microb Genom. 2018 11; 4(11). PMID: 30412460.
      View in: PubMed
    8. Horstmann N, Tran CN, Brumlow C, DebRoy S, Yao H, Nogueras Gonzalez G, Makthal N, Kumaraswami M, Shelburne SA. Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcus. PLoS Pathog. 2018 10; 14(10):e1007354. PMID: 30379939.
      View in: PubMed
    9. Foolad F, Taylor BD, Shelburne SA, Arias CA, Aitken SL. Association of daptomycin dosing regimen and mortality in patients with VRE bacteraemia: a review. J Antimicrob Chemother. 2018 Sep 01; 73(9):2277-2283. PMID: 29547977.
      View in: PubMed
    10. Flores AR, Chase McNeil J, Shah B, Van Beneden C, Shelburne SA. Capsule-Negative emm Types Are an Increasing Cause of Pediatric Group A Streptococcal Infections at a Large Pediatric Hospital in Texas. J Pediatric Infect Dis Soc. 2018 Aug 01. PMID: 30085121.
      View in: PubMed
    11. Lacourt TE, Kavelaars A, Ohanian M, Shah ND, Shelburne SA, Futreal A, Kontoyiannis DP, Heijnen CJ. Patient-reported fatigue prior to treatment is prognostic of survival in patients with acute myeloid leukemia. Oncotarget. 2018 Jul 27; 9(58):31244-31252. PMID: 30131851.
      View in: PubMed
    12. Li X, Arias CA, Aitken SL, Galloway Peña J, Panesso D, Chang M, Diaz L, Rios R, Numan Y, Ghaoui S, DebRoy S, Bhatti MM, Simmons DE, Raad I, Hachem R, Folan SA, Sahasarabhojane P, Kalia A, Shelburne SA. Clonal Emergence of Invasive Multidrug-Resistant Staphylococcus epidermidis Deconvoluted via a Combination of Whole-Genome Sequencing and Microbiome Analyses. Clin Infect Dis. 2018 Jul 18; 67(3):398-406. PMID: 29546356.
      View in: PubMed
    13. Folan SA, Marx KR, Tverdek FP, Raad I, Mulanovich VE, Tarrand JJ, Shelburne SA, Aitken SL. Clinical Outcomes Associated With Linezolid Resistance in Leukemia Patients With Linezolid-Resistant Staphylococcus epidermidis Bacteremia. Open Forum Infect Dis. 2018 Jul; 5(7):ofy167. PMID: 30090838.
      View in: PubMed
    14. Rolston KVI, Reitzel R, Vargas-Cruz N, Shelburne SA, Raad II, Prince RA. In vitro activity of tedizolid and comparator agents against clinical Gram-positive isolates recovered from patients with cancer. Diagn Microbiol Infect Dis. 2018 Aug; 91(4):351-353. PMID: 29661529.
      View in: PubMed
    15. Lacourt TE, Kavelaars A, Galloway-Peña JR, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ. Associations of inflammation with symptom burden in patients with acute myeloid leukemia. Psychoneuroendocrinology. 2018 03; 89:203-208. PMID: 29414033.
      View in: PubMed
    16. Shelburne SA, Kim J, Munita JM, Sahasrabhojane P, Shields RK, Press EG, Li X, Arias CA, Cantarel B, Jiang Y, Kim MS, Aitken SL, Greenberg DE. Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum ß-Lactams for Major Gram-Negative Bacterial Pathogens. Clin Infect Dis. 2017 09 01; 65(5):738-745. PMID: 28472260.
      View in: PubMed
    17. Horstmann N, Sahasrabhojane P, Yao H, Su X, Shelburne SA. Use of a Phosphorylation Site Mutant To Identify Distinct Modes of Gene Repression by the Control of Virulence Regulator (CovR) in Streptococcus pyogenes. J Bacteriol. 2017 09 15; 199(18). PMID: 28289082.
      View in: PubMed
    18. Galloway-Peña J, Brumlow C, Shelburne S. Impact of the Microbiota on Bacterial Infections during Cancer Treatment. Trends Microbiol. 2017 12; 25(12):992-1004. PMID: 28728967.
      View in: PubMed
    19. Reyes-Gibby CC, Melkonian SC, Wang J, Yu RK, Shelburne SA, Lu C, Gunn GB, Chambers MS, Hanna EY, Yeung SJ, Shete S. Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis. PLoS One. 2017; 12(7):e0180396. PMID: 28678827.
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    20. Munita JM, Aitken SL, Miller WR, Perez F, Rosa R, Shimose LA, Lichtenberger PN, Abbo LM, Jain R, Nigo M, Wanger A, Araos R, Tran TT, Adachi J, Rakita R, Shelburne S, Bonomo RA, Arias CA. Multicenter Evaluation of Ceftolozane/Tazobactam for Serious Infections Caused by Carbapenem-Resistant Pseudomonas aeruginosa. Clin Infect Dis. 2017 07 01; 65(1):158-161. PMID: 28329350.
      View in: PubMed
    21. Flores AR, Luna RA, Runge JK, Shelburne SA, Baker CJ. Cluster of Fatal Group A Streptococcal emm87 Infections in a Single Family: Molecular Basis for Invasion and Transmission. J Infect Dis. 2017 06 01; 215(11):1648-1652. PMID: 28383686.
      View in: PubMed
    22. Wadsworth WD, Argiento R, Guindani M, Galloway-Pena J, Shelburne SA, Vannucci M. Erratum to: An integrative Bayesian Dirichlet-multinomial regression model for the analysis of taxonomic abundances in microbiome data. BMC Bioinformatics. 2017 03 23; 18(1):185. PMID: 28335713.
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    23. Galloway-Peña JR, Jenq RR, Shelburne SA. Can Consideration of the Microbiome Improve Antimicrobial Utilization and Treatment Outcomes in the Oncology Patient? Clin Cancer Res. 2017 07 01; 23(13):3263-3268. PMID: 28298544.
      View in: PubMed
    24. Rolston KVI, Jamal MA, Nesher L, Shelburne SA, Raad I, Prince RA. In vitro activity of ceftaroline and comparator agents against Gram-positive and Gram-negative clinical isolates from cancer patients. Int J Antimicrob Agents. 2017 Apr; 49(4):416-421. PMID: 28257904.
      View in: PubMed
    25. Galloway-Peña JR, Smith DP, Sahasrabhojane P, Wadsworth WD, Fellman BM, Ajami NJ, Shpall EJ, Daver N, Guindani M, Petrosino JF, Kontoyiannis DP, Shelburne SA. Characterization of oral and gut microbiome temporal variability in hospitalized cancer patients. Genome Med. 2017 02 28; 9(1):21. PMID: 28245856.
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    26. Wadsworth WD, Argiento R, Guindani M, Galloway-Pena J, Shelburne SA, Vannucci M. An integrative Bayesian Dirichlet-multinomial regression model for the analysis of taxonomic abundances in microbiome data. BMC Bioinformatics. 2017 02 08; 18(1):94. PMID: 28178947.
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    27. Bhatti MD, Kalia A, Sahasrabhojane P, Kim J, Greenberg DE, Shelburne SA. Identification and Whole Genome Sequencing of the First Case of Kosakonia radicincitans Causing a Human Bloodstream Infection. Front Microbiol. 2017; 8:62. PMID: 28174569.
      View in: PubMed
    28. DiPippo AJ, Tverdek FP, Tarrand JJ, Munita JM, Tran TT, Arias CA, Shelburne SA, Aitken SL. Daptomycin non-susceptible Enterococcus faecium in leukemia patients: Role of prior daptomycin exposure. J Infect. 2017 03; 74(3):243-247. PMID: 27845153.
      View in: PubMed
    29. DebRoy S, Saldaña M, Travisany D, Montano A, Galloway-Peña J, Horstmann N, Yao H, González M, Maass A, Latorre M, Shelburne SA. A Multi-Serotype Approach Clarifies the Catabolite Control Protein A Regulon in the Major Human Pathogen Group A Streptococcus. Sci Rep. 2016 09 01; 6:32442. PMID: 27580596.
      View in: PubMed
    30. Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 09; 60(9):5130-4. PMID: 27551008.
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    31. Zhu L, Olsen RJ, Horstmann N, Shelburne SA, Fan J, Hu Y, Musser JM. Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes. Infect Immun. 2016 07; 84(7):2086-2093. PMID: 27141081.
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    32. Aitken SL, Tarrand JJ, Deshpande LM, Tverdek FP, Jones AL, Shelburne SA, Prince RA, Bhatti MM, Rolston KVI, Jones RN, Castanheira M, Chemaly RF. High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-ß-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center. Clin Infect Dis. 2016 10 01; 63(7):954-958. PMID: 27313265.
      View in: PubMed
    33. Galloway-Peña JR, Smith DP, Sahasrabhojane P, Ajami NJ, Wadsworth WD, Daver NG, Chemaly RF, Marsh L, Ghantoji SS, Pemmaraju N, Garcia-Manero G, Rezvani K, Alousi AM, Wargo JA, Shpall EJ, Futreal PA, Guindani M, Petrosino JF, Kontoyiannis DP, Shelburne SA. The role of the gastrointestinal microbiome in infectious complications during induction chemotherapy for acute myeloid leukemia. Cancer. 2016 07 15; 122(14):2186-96. PMID: 27142181.
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    34. Petrosyan V, Holder M, Ajami NJ, Petrosino JF, Sahasrabhojane P, Thompson EJ, Kalia A, Shelburne SA. Complete Genome Sequence of Streptococcus mitis Strain SVGS_061 Isolated from a Neutropenic Patient with Viridans Group Streptococcal Shock Syndrome. Genome Announc. 2016 Apr 07; 4(2). PMID: 27056234.
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    35. Shukla BS, Shelburne S, Reyes K, Kamboj M, Lewis JD, Rincon SL, Reyes J, Carvajal LP, Panesso D, Sifri CD, Zervos MJ, Pamer EG, Tran TT, Adachi J, Munita JM, Hasbun R, Arias CA. Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated With Daptomycin: Is it Time to Change the Breakpoint? Clin Infect Dis. 2016 06 15; 62(12):1514-1520. PMID: 27045126.
      View in: PubMed
    36. Galloway-Peña J, Clement ME, Sharma Kuinkel BK, Ruffin F, Flores AR, Levinson H, Shelburne SA, Moore Z, Fowler VG. Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease. Open Forum Infect Dis. 2016 Jan; 3(1):ofw042. PMID: 27006966.
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    37. Rolston KV, Wang W, Nesher L, Shelburne SA, Prince RA. In vitro activity of dalbavancin and five comparator agents against common and uncommon Gram-positive organisms isolated from cancer patients. J Antibiot (Tokyo). 2016 05; 69(5):381-7. PMID: 26626876.
      View in: PubMed
    38. Shelburne SA, Ajami NJ, Chibucos MC, Beird HC, Tarrand J, Galloway-Peña J, Albert N, Chemaly RF, Ghantoji SS, Marsh L, Pemmaraju N, Andreeff M, Shpall EJ, Wargo JA, Rezvani K, Alousi A, Bruno VM, Futreal PA, Petrosino JF, Kontoyiannis DP. Implementation of a Pan-Genomic Approach to Investigate Holobiont-Infecting Microbe Interaction: A Case Report of a Leukemic Patient with Invasive Mucormycosis. PLoS One. 2015; 10(11):e0139851. PMID: 26556047.
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    39. Miller EW, Danger JL, Ramalinga AB, Horstmann N, Shelburne SA, Sumby P. Regulatory rewiring confers serotype-specific hyper-virulence in the human pathogen group A Streptococcus. Mol Microbiol. 2015 Oct; 98(3):473-89. PMID: 26192205.
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    40. Teatero S, Athey TB, Van Caeseele P, Horsman G, Alexander DC, Melano RG, Li A, Flores AR, Shelburne SA, McGeer A, Demczuk W, Martin I, Fittipaldi N. Emergence of Serotype IV Group B Streptococcus Adult Invasive Disease in Manitoba and Saskatchewan, Canada, Is Driven by Clonal Sequence Type 459 Strains. J Clin Microbiol. 2015 Sep; 53(9):2919-26. PMID: 26135871.
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    41. Flores AR, Galloway-Peña J, Sahasrabhojane P, Saldaña M, Yao H, Su X, Ajami NJ, Holder ME, Petrosino JF, Thompson E, Margarit Y Ros I, Rosini R, Grandi G, Horstmann N, Teatero S, McGeer A, Fittipaldi N, Rappuoli R, Baker CJ, Shelburne SA. Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):6431-6. PMID: 25941374.
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    42. Horstmann N, Sahasrabhojane P, Saldaña M, Ajami NJ, Flores AR, Sumby P, Liu CG, Yao H, Su X, Thompson E, Shelburne SA. Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus. Infect Immun. 2015 Mar; 83(3):1068-77. PMID: 25561708.
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    43. Galloway-Peña JR, Liang X, Singh KV, Yadav P, Chang C, La Rosa SL, Shelburne S, Ton-That H, Höök M, Murray BE. The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions. J Bacteriol. 2015 Mar; 197(5):882-92. PMID: 25512313.
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    44. Holland T, Fowler VG, Shelburne SA. Invasive gram-positive bacterial infection in cancer patients. Clin Infect Dis. 2014 Nov 15; 59 Suppl 5:S331-4. PMID: 25352626.
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    45. Shelburne SA, Chaftari AM, Jamal M, Al Wohoush I, Jiang Y, Abughazaleh S, Cairo J, Raad S, Debiane L, Raad I. Identification and characterization of catheter-related bloodstream infections due to viridans group streptococci in patients with cancer. Am J Infect Control. 2014 Oct; 42(10):1127-9. PMID: 25278410.
      View in: PubMed
    46. Flores AR, Jewell BE, Olsen RJ, Shelburne SA, Fittipaldi N, Beres SB, Musser JM. Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production. Infect Immun. 2014 Sep; 82(9):3958-67. PMID: 25024363.
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    47. Galloway-Peña J, Sahasrabhojane P, Tarrand J, Han XY, Shelburne SA. GyrB polymorphisms accurately assign invasive viridans group streptococcal species. J Clin Microbiol. 2014 Aug; 52(8):2905-12. PMID: 24899021.
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    48. Rolston K, Wang W, Nesher L, Coyle E, Shelburne S, Prince RA. In vitro activity of telavancin compared with vancomycin and linezolid against Gram-positive organisms isolated from cancer patients. J Antibiot (Tokyo). 2014 Jul; 67(7):505-9. PMID: 24824818.
      View in: PubMed
    49. Horstmann N, Saldaña M, Sahasrabhojane P, Yao H, Su X, Thompson E, Koller A, Shelburne SA. Dual-site phosphorylation of the control of virulence regulator impacts group a streptococcal global gene expression and pathogenesis. PLoS Pathog. 2014 May; 10(5):e1004088. PMID: 24788524.
      View in: PubMed
    50. Shelburne SA, Sahasrabhojane P, Saldana M, Yao H, Su X, Horstmann N, Thompson E, Flores AR. Streptococcus mitis strains causing severe clinical disease in cancer patients. Emerg Infect Dis. 2014 May; 20(5):762-71. PMID: 24750901.
      View in: PubMed
    51. Shelburne SA, Lasky RE, Sahasrabhojane P, Tarrand JT, Rolston KV. Development and validation of a clinical model to predict the presence of ß-lactam resistance in viridans group streptococci causing bacteremia in neutropenic cancer patients. Clin Infect Dis. 2014 Jul 15; 59(2):223-30. PMID: 24755857.
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    52. Sahasrabhojane P, Galloway-Peña J, Velazquez L, Saldaña M, Horstmann N, Tarrand J, Shelburne SA. Species-level assessment of the molecular basis of fluoroquinolone resistance among viridans group streptococci causing bacteraemia in cancer patients. Int J Antimicrob Agents. 2014 Jun; 43(6):558-62. PMID: 24721231.
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    53. El Zakhem A, Chaftari AM, Bahu R, El Helou G, Shelburne S, Jiang Y, Hachem R, Raad I. Central line-associated bloodstream infections caused by Staphylococcus aureus in cancer patients: Clinical outcome and management. Ann Med. 2014 May; 46(3):163-8. PMID: 24491173.
      View in: PubMed
    54. Flores AR, Sahasrabhojane P, Saldaña M, Galloway-Peña J, Olsen RJ, Musser JM, Shelburne SA. Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient. J Infect Dis. 2014 May 15; 209(10):1520-3. PMID: 24307742.
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    55. Flores AR, Olsen RJ, Wunsche A, Kumaraswami M, Shelburne SA, Carroll RK, Musser JM. Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains. Infect Immun. 2013 Nov; 81(11):4128-38. PMID: 23980109.
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    56. Shelburne SA, Tarrand J, Rolston KV. Review of streptococcal bloodstream infections at a comprehensive cancer care center, 2000-2011. J Infect. 2013 Feb; 66(2):136-46. PMID: 23182968.
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    57. White CN, Shelburne S. Streptococcal infections: understanding the various species and strains. JAAPA. 2012 Nov; 25(11):23-4. PMID: 23620919.
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    58. Horstmann N, Orans J, Valentin-Hansen P, Shelburne SA, Brennan RG. Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract. Nucleic Acids Res. 2012 Nov; 40(21):11023-35. PMID: 22965117.
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    59. Olsen RJ, Laucirica DR, Watkins ME, Feske ML, Garcia-Bustillos JR, Vu C, Cantu C, Shelburne SA, Fittipaldi N, Kumaraswami M, Shea PR, Flores AR, Beres SB, Lovgren M, Tyrrell GJ, Efstratiou A, Low DE, Van Beneden CA, Musser JM. Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus. J Infect Dis. 2012 Jun; 205(11):1719-29. PMID: 22262791.
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    60. Lin E, Bhusal Y, Horwitz D, Shelburne SA, Trautner BW. Overtreatment of enterococcal bacteriuria. Arch Intern Med. 2012 Jan 09; 172(1):33-8. PMID: 22232145.
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    61. Shelburne SA, Olsen RJ, Makthal N, Brown NG, Sahasrabhojane P, Watkins EM, Palzkill T, Musser JM, Kumaraswami M. An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes. Mol Microbiol. 2011 Dec; 82(6):1481-95. PMID: 22040048.
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    62. Horstmann N, Sahasrabhojane P, Suber B, Kumaraswami M, Olsen RJ, Flores A, Musser JM, Brennan RG, Shelburne SA. Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. PLoS Pathog. 2011 Oct; 7(10):e1002311. PMID: 22028655.
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    63. Shelburne SA, Sahasrobhajane P, Suber B, Keith DB, Davenport MT, Horstmann N, Kumaraswami M, Olsen RJ, Brennan RG, Musser JM. Niche-specific contribution to streptococcal virulence of a MalR-regulated carbohydrate binding protein. Mol Microbiol. 2011 Jul; 81(2):500-14. PMID: 21645132.
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    64. Carroll RK, Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM. Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice. J Clin Invest. 2011 May; 121(5):1956-68. PMID: 21490401.
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    65. Kung DH, Hubenthal EA, Kwan JY, Shelburne SA, Goodman JC, Kass JS. Toxoplasmosis myelopathy and myopathy in an AIDS patient: a case of immune reconstitution inflammatory syndrome? Neurologist. 2011 Jan; 17(1):49-51. PMID: 21192196.
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    66. Shelburne SA, Olsen RJ, Suber B, Sahasrabhojane P, Sumby P, Brennan RG, Musser JM. A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. PLoS Pathog. 2010 Mar 19; 6(3):e1000817. PMID: 20333240.
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    67. Shelburne Iii SA, Keith DB, Davenport MT, Beres SB, Carroll RK, Musser JM. Contribution of AmyA, an extracellular alpha-glucan degrading enzyme, to group A streptococcal host-pathogen interaction. Mol Microbiol. 2009 Oct; 74(1):159-174. PMID: 19735442.
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    68. Musser JM, Shelburne SA. A decade of molecular pathogenomic analysis of group A Streptococcus. J Clin Invest. 2009 Sep; 119(9):2455-63. PMID: 19729843.
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    69. Safdar A, Shelburne SA, Evans SE, Dickey BF. Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf. 2009 Jul; 8(4):435-49. PMID: 19538104.
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    70. Treviño J, Perez N, Ramirez-Peña E, Liu Z, Shelburne SA, Musser JM, Sumby P. CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes. Infect Immun. 2009 Aug; 77(8):3141-9. PMID: 19451242.
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    71. Shelburne SA. Empirical use of fluconazole in critically ill patients: good study, but what was the hold-up? Ann Intern Med. 2009 Jan 06; 150(1):58-9; author reply 59-60. PMID: 19124825.
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    72. Olsen RJ, Shelburne SA, Musser JM. Molecular mechanisms underlying group A streptococcal pathogenesis. Cell Microbiol. 2009 Jan; 11(1):1-12. PMID: 18710460.
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    73. Shelburne SA, Keith DB, Davenport MT, Horstmann N, Brennan RG, Musser JM. Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis. Mol Microbiol. 2008 Jul; 69(2):436-52. PMID: 18485073.
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    74. Livorsi DJ, Daver NG, Atmar RL, Shelburne SA, White AC, Musher DM. Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA ERA. J Infect. 2008 Aug; 57(2):128-31. PMID: 18562009.
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    75. Shelburne SA, Davenport MT, Keith DB, Musser JM. The role of complex carbohydrate catabolism in the pathogenesis of invasive streptococci. Trends Microbiol. 2008 Jul; 16(7):318-25. PMID: 18508271.
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    76. Shelburne SA, Keith D, Horstmann N, Sumby P, Davenport MT, Graviss EA, Brennan RG, Musser JM. A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1698-703. PMID: 18230719.
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    77. Shelburne SA, Singh KV, White AC, Byrne L, Carmer A, Austin C, Graviss E, Stager C, Murray BE, Atmar RL. Sequential outbreaks of infections by distinct Acinetobacter baumannii strains in a public teaching hospital in Houston, Texas. J Clin Microbiol. 2008 Jan; 46(1):198-205. PMID: 18003801.
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    78. Shelburne SA, Okorafor N, Sitkiewicz I, Sumby P, Keith D, Patel P, Austin C, Graviss EA, Musser JM. Regulation of polysaccharide utilization contributes to the persistence of group a streptococcus in the oropharynx. Infect Immun. 2007 Jun; 75(6):2981-90. PMID: 17403878.
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    79. Shelburne SA, Fang H, Okorafor N, Sumby P, Sitkiewicz I, Keith D, Patel P, Austin C, Graviss EA, Musser JM, Chow DC. MalE of group A Streptococcus participates in the rapid transport of maltotriose and longer maltodextrins. J Bacteriol. 2007 Apr; 189(7):2610-7. PMID: 17259319.
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    80. Daver NG, Shelburne SA, Atmar RL, Giordano TP, Stager CE, Reitman CA, White AC. Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis. J Infect. 2007 Jun; 54(6):539-44. PMID: 17198732.
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    81. Gonzalez BE, Rueda AM, Shelburne SA, Musher DM, Hamill RJ, Hulten KG. Community-associated strains of methicillin-resistant Staphylococccus aureus as the cause of healthcare-associated infection. Infect Control Hosp Epidemiol. 2006 Oct; 27(10):1051-6. PMID: 17006811.
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    82. Shelburne SA, Sumby P, Sitkiewicz I, Okorafor N, Granville C, Patel P, Voyich J, Hull R, DeLeo FR, Musser JM. Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx. Infect Immun. 2006 Aug; 74(8):4605-14. PMID: 16861648.
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    83. Kaka AS, Rueda AM, Shelburne SA, Hulten K, Hamill RJ, Musher DM. Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 2006 Sep; 58(3):680-3. PMID: 16840428.
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    84. Shelburne SA, Greenberg SB, Aslam S, Tweardy DJ. Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci. J Infect. 2007 Feb; 54(2):e99-101. PMID: 16824611.
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    85. Shelburne SA, Montes M, Hamill RJ. Immune reconstitution inflammatory syndrome: more answers, more questions. J Antimicrob Chemother. 2006 Feb; 57(2):167-70. PMID: 16354748.
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    86. Shelburne SA, Sumby P, Sitkiewicz I, Granville C, DeLeo FR, Musser JM. Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):16037-42. PMID: 16249338.
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    87. Shelburne SA, Visnegarwala F, Adams C, Krause KL, Hamill RJ, White AC. Unusual manifestations of disseminated Histoplasmosis in patients responding to antiretroviral therapy. Am J Med. 2005 Sep; 118(9):1038-41. PMID: 16164892.
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    88. Shelburne SA, Granville C, Tokuyama M, Sitkiewicz I, Patel P, Musser JM. Growth characteristics of and virulence factor production by group A Streptococcus during cultivation in human saliva. Infect Immun. 2005 Aug; 73(8):4723-31. PMID: 16040985.
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    89. Shelburne SA, Visnegarwala F, Darcourt J, Graviss EA, Giordano TP, White AC, Hamill RJ. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS. 2005 Mar 04; 19(4):399-406. PMID: 15750393.
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    90. Shelburne SA, Darcourt J, White AC, Greenberg SB, Hamill RJ, Atmar RL, Visnegarwala F. The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy. Clin Infect Dis. 2005 Apr 01; 40(7):1049-52. PMID: 15825000.
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    91. Shelburne SA, Musher DM, Hulten K, Ceasar H, Lu MY, Bhaila I, Hamill RJ. In vitro killing of community-associated methicillin-resistant Staphylococcus aureus with drug combinations. Antimicrob Agents Chemother. 2004 Oct; 48(10):4016-9. PMID: 15388469.
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    92. Shelburne SA, Musser JM. Virulence gene expression in vivo. Curr Opin Microbiol. 2004 Jun; 7(3):283-9. PMID: 15196497.
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    93. Shelburne SA, Kielhofner MA, Tiwari PS. Cerebellar involvement in legionellosis. South Med J. 2004 Jan; 97(1):61-4. PMID: 14746424.
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    94. Shelburne SA, Hamill RJ. The immune reconstitution inflammatory syndrome. AIDS Rev. 2003 Apr-Jun; 5(2):67-79. PMID: 12876896.
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    95. Shelburne SA, Hamill RJ, Rodriguez-Barradas MC, Greenberg SB, Atmar RL, Musher DW, Gathe JC, Visnegarwala F, Trautner BW. Immune reconstitution inflammatory syndrome: emergence of a unique syndrome during highly active antiretroviral therapy. Medicine (Baltimore). 2002 May; 81(3):213-27. PMID: 11997718.
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    96. Gamstorp I, Shelburne SA, O'Flynn ME. Conduction velocity of peripheral nerves in children with phenylketonuria. Neurology. 1966 Jun; 16(6):556-8. PMID: 5949231.
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    97. Regulatory rewiring confers serotype-specific hyper-virulence in the human pathogen group A Streptococcus. Molecular Microbiology. 98:473-489.
    98. Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated with Daptomycin. Clinical Infectious Diseases. 62:1514-1520.
    99. Intergenic variable-number tandem-repeat polymorphism upstream of rocA alters toxin production and enhances virulence in Streptococcus pyogenes. Infection and Immunity. 84:2086-2093.
    100. Emergence of serotype IV group B streptococcus adult invasive disease in Manitoba and saskatchewan, Canada, is driven by clonal sequence type 459 strains. Journal of Clinical Microbiology. 53:2919-2926.
    101. Immune reconstitution inflammatory syndrome. 699-706.
    102. Successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient. Antimicrobial Agents and Chemotherapy. 60:5130-5134.
    103. Immune reconstitution inflammatory syndrome. Journal of Antimicrobial Chemotherapy. 58:1094-1095.
    104. Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes. Proceedings of the National Academy of Sciences of the United States of America. 112:6431-6436.
    105. Application of whole-genome sequencing to an unusual outbreak of invasive group a streptococcal disease. Open Forum Infectious Diseases. 3.
    106. Daptomycin non-susceptible Enterococcus faecium in leukemia patients. Journal of Infection.
    107. High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center. Clinical Infectious Diseases. 63:954-958.
    108. A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 5, (1698-1703) DOI. Proceedings of the National Academy of Sciences of the United States of America. 106:8790.
    109. In vitro activity of dalbavancin and five comparator agents against common and uncommon Gram-positive organisms isolated from cancer patients. Journal of Antibiotics. 69:381-387.
    110. Implementation of a pan-genomic approach to investigate holobiont-infecting microbe interaction. PLoS One. 10.
    111. A Multi-Serotype Approach Clarifies the Catabolite Control Protein A Regulon in the Major Human Pathogen Group A Streptococcus. Scientific Reports. 6.
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