RANDY L JOHNSON

TitleProfessor
InstitutionMD Anderson
DepartmentCancer Biology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Park YY, Sohn BH, Johnson RL, Kang MH, Kim SB, Shim JJ, Mangala LS, Kim JH, Yoo JE, Rodriguez-Aguayo C, Pradeep S, Hwang JE, Jang HJ, Lee HS, Rupaimoole R, Lopez-Berestein G, Jeong W, Park IS, Park YN, Sood AK, Mills GB, Lee JS. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology. 2016 Jan; 63(1):159-72. PMID: 26389641.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    2. Chen Q, Song S, Wei S, Liu B, Honjo S, Scott A, Jin J, Ma L, Zhu H, Skinner HD, Johnson RL, Ajani JA. ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer. Oncotarget. 2015 Sep 22; 6(28):25883-96. PMID: 26317542.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    3. Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, Wu TT, Johnson RL, Hung MC, Ajani JA. The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. Clin Cancer Res. 2015 Jun 01; 21(11):2580-90. PMID: 25739674.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    4. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell. 2014 Jul 03; 158(1):185-197. PMID: 24954535.
      Citations: 197     Fields:    Translation:HumansAnimalsCells
    5. Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, Hung MC, Johnson RL. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 2014 Aug 01; 74(15):4170-82. PMID: 24906622.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    6. Honjo S, Ajani JA, Scott AW, Chen Q, Skinner HD, Stroehlein J, Johnson RL, Song S. Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. Int J Oncol. 2014 Aug; 45(2):567-74. PMID: 24859412.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    7. Jeong W, Kim SB, Sohn BH, Park YY, Park ES, Kim SC, Kim SS, Johnson RL, Birrer M, Bowtell DSL, Mills GB, Sood A, Lee JS. Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer. Anticancer Res. 2014 Feb; 34(2):811-817. PMID: 24511017.
      Citations: 24     Fields:    Translation:HumansCells
    8. Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB. Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol. 2014 Mar; 34(6):1170-86. PMID: 24421389.
      Citations: 13     Fields:    Translation:AnimalsCells
    9. Song JY, Park R, Kim JY, Hughes L, Lu L, Kim S, Johnson RL, Cho SH. Dual function of Yap in the regulation of lens progenitor cells and cellular polarity. Dev Biol. 2014 Feb 15; 386(2):281-90. PMID: 24384391.
      Citations: 22     Fields:    Translation:AnimalsCells
    10. Anderegg A, Lin HP, Chen JA, Caronia-Brown G, Cherepanova N, Yun B, Joksimovic M, Rock J, Harfe BD, Johnson R, Awatramani R. An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genet. 2013; 9(12):e1003973. PMID: 24348261.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    11. Heallen T, Morikawa Y, Leach J, Tao G, Willerson JT, Johnson RL, Martin JF. Hippo signaling impedes adult heart regeneration. Development. 2013 Dec; 140(23):4683-90. PMID: 24255096.
      Citations: 135     Fields:    Translation:AnimalsCells
    12. Anakk S, Bhosale M, Schmidt VA, Johnson RL, Finegold MJ, Moore DD. Bile acids activate YAP to promote liver carcinogenesis. Cell Rep. 2013 Nov 27; 5(4):1060-9. PMID: 24268772.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    13. Ajani JA, Wang X, Song S, Suzuki A, Taketa T, Sudo K, Wadhwa R, Hofstetter WL, Komaki R, Maru DM, Lee JH, Bhutani MS, Weston B, Baladandayuthapani V, Yao Y, Honjo S, Scott AW, Skinner HD, Johnson RL, Berry D. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients. Mol Oncol. 2014 Feb; 8(1):142-9. PMID: 24210755.
      Citations: 36     Fields:    Translation:HumansCells
    14. Takahashi Y, Yasuhiko Y, Takahashi J, Takada S, Johnson RL, Saga Y, Kanno J. Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo. Dev Biol. 2013 Aug 15; 380(2):172-84. PMID: 23727513.
      Citations: 5     Fields:    Translation:Animals
    15. Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol. 2013 Apr 17; 13:67. PMID: 23590285.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    16. Wang M, VanHouten JN, Nasiri AR, Johnson RL, Broadus AE. PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth. J Bone Miner Res. 2013 Mar; 28(3):598-607. PMID: 23109045.
      Citations: 11     Fields:    Translation:Animals
    17. Hippenmeyer S, Johnson RL, Luo L. Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance. Cell Rep. 2013 Mar 28; 3(3):960-7. PMID: 23453967.
      Citations: 17     Fields:    Translation:AnimalsCells
    18. George NM, Day CE, Boerner BP, Johnson RL, Sarvetnick NE. Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol. 2012 Dec; 32(24):5116-28. PMID: 23071096.
      Citations: 44     Fields:    Translation:AnimalsCells
    19. Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin MA, Johnson R, Fan CM, Relaix F, Shi DL, Duprez D. Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development. 2012 Jun; 139(11):1910-20. PMID: 22513369.
      Citations: 13     Fields:    Translation:AnimalsCells
    20. Katz TC, Singh MK, Degenhardt K, Rivera-Feliciano J, Johnson RL, Epstein JA, Tabin CJ. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell. 2012 Mar 13; 22(3):639-50. PMID: 22421048.
      Citations: 116     Fields:    Translation:AnimalsCells
    21. Xiang CX, Zhang KH, Johnson RL, Jacquin MF, Chen ZF. The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex. Somatosens Mot Res. 2012; 29(1):1-12. PMID: 22397680.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Joksimovic M, Patel M, Taketo MM, Johnson R, Awatramani R. Ectopic Wnt/beta-catenin signaling induces neurogenesis in the spinal cord and hindbrain floor plate. PLoS One. 2012; 7(1):e30266. PMID: 22276170.
      Citations: 18     Fields:    Translation:AnimalsCells
    23. Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H. Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers. Development. 2011 Nov; 138(21):4609-19. PMID: 21989910.
      Citations: 38     Fields:    Translation:AnimalsCells
    24. Yan CH, Levesque M, Claxton S, Johnson RL, Ang SL. Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. J Neurosci. 2011 Aug 31; 31(35):12413-25. PMID: 21880902.
      Citations: 47     Fields:    Translation:AnimalsCells
    25. Foster KW, Saranak J, Krane S, Johnson RL, Nakanishi K. Evidence from Chlamydomonas on the photoactivation of rhodopsins without isomerization of their chromophore. Chem Biol. 2011 Jun 24; 18(6):733-42. PMID: 21700209.
      Citations:    Fields:    Translation:AnimalsCells
    26. Thenappan A, Shukla V, Abdul Khalek FJ, Li Y, Shetty K, Liu P, Li L, Johnson RL, Johnson L, Mishra L. Loss of transforming growth factor ß adaptor protein ß-2 spectrin leads to delayed liver regeneration in mice. Hepatology. 2011 May; 53(5):1641-50. PMID: 21520177.
      Citations: 19     Fields:    Translation:Animals
    27. Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011 Apr 22; 332(6028):458-61. PMID: 21512031.
      Citations: 357     Fields:    Translation:AnimalsCells
    28. Liu P, Fu X, Johnson RL. Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):969-74. PMID: 21051732.
      Citations: 3     Fields:    Translation:AnimalsCells
    29. Halder G, Johnson RL. Hippo signaling: growth control and beyond. Development. 2011 Jan; 138(1):9-22. PMID: 21138973.
      Citations: 396     Fields:    Translation:AnimalsCells
    30. Liu P, Johnson RL. Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency. Dev Dyn. 2010 Aug; 239(8):2161-71. PMID: 20568247.
      Citations: 10     Fields:    Translation:Animals
    31. Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9753-8. PMID: 20457925.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    32. Li Y, Qiu Q, Watson SS, Schweitzer R, Johnson RL. Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning. Development. 2010 Apr; 137(7):1181-8. PMID: 20215352.
      Citations: 13     Fields:    Translation:AnimalsCells
    33. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1437-42. PMID: 20080689.
      Citations: 292     Fields:    Translation:AnimalsCells
    34. Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ, Harrow J, Grafham D, Hentges KE, Woodward LP, Maxwell A, Mitchell K, Risley MD, Johnson R, Hirschi K, Lupski JR, Funato Y, Miki H, Marin-Garcia P, Matthews L, Coffey AJ, Parker A, Hubbard TJ, Rogers J, Bradley A, Adams DJ, Justice MJ. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet. 2009 Dec; 5(12):e1000759. PMID: 20011118.
      Citations: 22     Fields:    Translation:Animals
    35. Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, Zelzer E. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell. 2009 Dec; 17(6):861-73. PMID: 20059955.
      Citations: 93     Fields:    Translation:Animals
    36. Mishima Y, Lindgren AG, Chizhikov VV, Johnson RL, Millen KJ. Overlapping function of Lmx1a and Lmx1b in anterior hindbrain roof plate formation and cerebellar growth. J Neurosci. 2009 Sep 09; 29(36):11377-84. PMID: 19741143.
      Citations: 15     Fields:    Translation:Animals
    37. Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC. Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11612-6. PMID: 19556538.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    38. Qiu Q, Chen H, Johnson RL. Lmx1b-expressing cells in the mouse limb bud define a dorsal mesenchymal lineage compartment. Genesis. 2009 Apr; 47(4):224-33. PMID: 19298015.
      Citations: 8     Fields:    Translation:AnimalsCells
    39. Dai JX, Johnson RL, Ding YQ. Manifold functions of the Nail-Patella Syndrome gene Lmx1b in vertebrate development. Dev Growth Differ. 2009 Apr; 51(3):241-50. PMID: 19222527.
      Citations: 12     Fields:    Translation:HumansAnimals
    40. Guo C, Qiu HY, Shi M, Huang Y, Johnson RL, Rubinstein M, Chen SD, Ding YQ. Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. J Neurosci. 2008 Dec 24; 28(52):14097-106. PMID: 19109492.
      Citations: 2     Fields:    Translation:AnimalsCells
    41. Hodges MR, Tattersall GJ, Harris MB, McEvoy SD, Richerson DN, Deneris ES, Johnson RL, Chen ZF, Richerson GB. Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J Neurosci. 2008 Mar 05; 28(10):2495-505. PMID: 18322094.
      Citations: 143     Fields:    Translation:AnimalsCells
    42. Endele S, Klein S, Richter S, Molter T, Amann K, Klanke B, Witzgall R, Johnson RL, Hilgers KF, Winterpacht A. Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomy. Transgenic Res. 2007 Dec; 16(6):723-9. PMID: 17657578.
      Citations: 4     Fields:    Translation:HumansAnimals
    43. Zhao ZQ, Chiechio S, Sun YG, Zhang KH, Zhao CS, Scott M, Johnson RL, Deneris ES, Renner KJ, Gereau RW, Chen ZF. Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. J Neurosci. 2007 May 30; 27(22):6045-53. PMID: 17537976.
      Citations: 48     Fields:    Translation:AnimalsCells
    44. Suleiman H, Heudobler D, Raschta AS, Zhao Y, Zhao Q, Hertting I, Vitzthum H, Moeller MJ, Holzman LB, Rachel R, Johnson R, Westphal H, Rascle A, Witzgall R. The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes. Dev Biol. 2007 Apr 15; 304(2):701-12. PMID: 17316599.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    45. Guo C, Qiu HY, Huang Y, Chen H, Yang RQ, Chen SD, Johnson RL, Chen ZF, Ding YQ. Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development. 2007 Jan; 134(2):317-25. PMID: 17166916.
      Citations: 39     Fields:    Translation:Animals
    46. Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW, Johnson RL, Deneris ES, Chen ZF. Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006 Dec 06; 26(49):12781-8. PMID: 17151281.
      Citations: 97     Fields:    Translation:AnimalsCells
    47. Gould DB, Reedy M, Wilson LA, Smith RS, Johnson RL, John SW. Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma. Mol Cell Biol. 2006 Nov; 26(22):8427-36. PMID: 16954374.
      Citations: 33     Fields:    Translation:AnimalsCells
    48. Holderfield MT, Henderson Anderson AM, Kokubo H, Chin MT, Johnson RL, Hughes CC. HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. Biochem Biophys Res Commun. 2006 Aug 04; 346(3):637-48. PMID: 16782059.
      Citations: 16     Fields:    Translation:HumansCells
    49. Chen YT, Kobayashi A, Kwan KM, Johnson RL, Behringer RR. Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice. BMC Nephrol. 2006 Feb 07; 7:1. PMID: 16464245.
      Citations: 9     Fields:    Translation:AnimalsCells
    50. Seo KW, Wang Y, Kokubo H, Kettlewell JR, Zarkower DA, Johnson RL. Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning. Dev Biol. 2006 Feb 01; 290(1):200-10. PMID: 16387292.
      Citations: 24     Fields:    Translation:AnimalsCells
    51. Kokubo H, Miyagawa-Tomita S, Johnson RL. Hesr, a mediator of the Notch signaling, functions in heart and vessel development. Trends Cardiovasc Med. 2005 Jul; 15(5):190-4. PMID: 16165016.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    52. Dunston JA, Reimschisel T, Ding YQ, Sweeney E, Johnson RL, Chen ZF, McIntosh I. A neurological phenotype in nail patella syndrome (NPS) patients illuminated by studies of murine Lmx1b expression. Eur J Hum Genet. 2005 Mar; 13(3):330-5. PMID: 15562281.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    53. Kokubo H, Miyagawa-Tomita S, Nakazawa M, Saga Y, Johnson RL. Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol. 2005 Feb 15; 278(2):301-9. PMID: 15680351.
      Citations: 55     Fields:    Translation:AnimalsCells
    54. Zhang D, Choi DW, Wanamaker S, Fenton RD, Chin A, Malatrasi M, Turuspekov Y, Walia H, Akhunov ED, Kianian P, Otto C, Simons K, Deal KR, Echenique V, Stamova B, Ross K, Butler GE, Strader L, Verhey SD, Johnson R, Altenbach S, Kothari K, Tanaka C, Shah MM, Laudencia-Chingcuanco D, Han P, Miller RE, Crossman CC, Chao S, Lazo GR, Klueva N, Gustafson JP, Kianian SF, Dubcovsky J, Walker-Simmons MK, Gill KS, Dvorák J, Anderson OD, Sorrells ME, McGuire PE, Qualset CO, Nguyen HT, Close TJ. Construction and evaluation of cDNA libraries for large-scale expressed sequence tag sequencing in wheat (Triticum aestivum L.). Genetics. 2004 Oct; 168(2):595-608. PMID: 15514038.
      Citations: 25     Fields:    Translation:Animals
    55. Kokubo H, Miyagawa-Tomita S, Tomimatsu H, Nakashima Y, Nakazawa M, Saga Y, Johnson RL. Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004 Sep 03; 95(5):540-7. PMID: 15297376.
      Citations: 32     Fields:    Translation:Animals
    56. Dreyer SD, Naruse T, Morello R, Zabel B, Winterpacht A, Johnson RL, Lee B, Oberg KC. Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets. Gene Expr Patterns. 2004 Jul; 4(4):397-405. PMID: 15183306.
      Citations: 7     Fields:    Translation:Animals
    57. Ding YQ, Yin J, Kania A, Zhao ZQ, Johnson RL, Chen ZF. Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord. Development. 2004 Aug; 131(15):3693-703. PMID: 15229182.
      Citations: 29     Fields:    Translation:AnimalsCells
    58. Schweizer H, Johnson RL, Brand-Saberi B. Characterization of migration behavior of myogenic precursor cells in the limb bud with respect to Lmx1b expression. Anat Embryol (Berl). 2004 Apr; 208(1):7-18. PMID: 15007643.
      Citations: 3     Fields:    Translation:AnimalsCells
    59. Cheng L, Chen CL, Luo P, Tan M, Qiu M, Johnson R, Ma Q. Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci. 2003 Nov 05; 23(31):9961-7. PMID: 14602809.
      Citations: 56     Fields:    Translation:AnimalsCells
    60. Kile BT, Hentges KE, Clark AT, Nakamura H, Salinger AP, Liu B, Box N, Stockton DW, Johnson RL, Behringer RR, Bradley A, Justice MJ. Functional genetic analysis of mouse chromosome 11. Nature. 2003 Sep 04; 425(6953):81-6. PMID: 12955145.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    61. Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, Deneris E, Johnson RL, Chen ZF. Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci. 2003 Sep; 6(9):933-8. PMID: 12897786.
      Citations: 85     Fields:    Translation:AnimalsCells
    62. Reedy MV, Johnson RL, Erickson CA. The expression patterns of c-kit and Sl in chicken embryos suggest unexpected roles for these genes in somite and limb development. Gene Expr Patterns. 2003 Mar; 3(1):53-8. PMID: 12609603.
      Citations: 8     Fields:    Translation:Animals
    63. Rohr C, Prestel J, Heidet L, Hosser H, Kriz W, Johnson RL, Antignac C, Witzgall R. The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes. J Clin Invest. 2002 Apr; 109(8):1073-82. PMID: 11956245.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    64. Chen H, Johnson RL. Interactions between dorsal-ventral patterning genes lmx1b, engrailed-1 and wnt-7a in the vertebrate limb. Int J Dev Biol. 2002; 46(7):937-41. PMID: 12455631.
      Citations: 18     Fields:    Translation:Animals
    65. Kim BS, Savinova OV, Reedy MV, Martin J, Lun Y, Gan L, Smith RS, Tomarev SI, John SW, Johnson RL. Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function. Mol Cell Biol. 2001 Nov; 21(22):7707-13. PMID: 11604506.
      Citations: 92     Fields:    Translation:HumansAnimals
    66. Tabin CJ, Johnson RL. Developmental biology: clocks and hox. Nature. 2001 Aug 23; 412(6849):780-1. PMID: 11518950.
      Citations: 3     Fields:    Translation:AnimalsCells
    67. Kos R, Reedy MV, Johnson RL, Erickson CA. The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. Development. 2001 Apr; 128(8):1467-79. PMID: 11262245.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    68. Wang SW, Kim BS, Ding K, Wang H, Sun D, Johnson RL, Klein WH, Gan L. Requirement for math5 in the development of retinal ganglion cells. Genes Dev. 2001 Jan 01; 15(1):24-9. PMID: 11156601.
      Citations: 182     Fields:    Translation:AnimalsCells
    69. Vadlamudi RK, Wang RA, Talukder AH, Adam L, Johnson R, Kumar R. Evidence of Rab3A expression, regulation of vesicle trafficking, and cellular secretion in response to heregulin in mammary epithelial cells. Mol Cell Biol. 2000 Dec; 20(23):9092-101. PMID: 11074007.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    70. Capdevila J, Johnson RL. Hedgehog signaling in vertebrate and invertebrate limb patterning. Cell Mol Life Sci. 2000 Nov; 57(12):1682-94. PMID: 11130175.
      Citations: 9     Fields:    Translation:AnimalsCells
    71. Kania A, Johnson RL, Jessell TM. Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. Cell. 2000 Jul 21; 102(2):161-73. PMID: 10943837.
      Citations: 89     Fields:    Translation:AnimalsCells
    72. Smidt MP, Asbreuk CH, Cox JJ, Chen H, Johnson RL, Burbach JP. A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nat Neurosci. 2000 Apr; 3(4):337-41. PMID: 10725922.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    73. Pressman CL, Chen H, Johnson RL. LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye. Genesis. 2000 Jan; 26(1):15-25. PMID: 10660670.
      Citations: 40     Fields:    Translation:AnimalsCells
    74. Lu MF, Pressman C, Dyer R, Johnson RL, Martin JF. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Nature. 1999 Sep 16; 401(6750):276-8. PMID: 10499585.
      Citations: 142     Fields:    Translation:Animals
    75. Kokubo H, Lun Y, Johnson RL. Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. Biochem Biophys Res Commun. 1999 Jul 05; 260(2):459-65. PMID: 10403790.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    76. Pathi S, Rutenberg JB, Johnson RL, Vortkamp A. Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation. Dev Biol. 1999 May 15; 209(2):239-53. PMID: 10328918.
      Citations: 43     Fields:    Translation:Animals
    77. Chen H, Johnson RL. Dorsoventral patterning of the vertebrate limb: a process governed by multiple events. Cell Tissue Res. 1999 Apr; 296(1):67-73. PMID: 10199966.
      Citations: 9     Fields:    Translation:HumansAnimals
    78. Aulehla A, Johnson RL. Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation. Dev Biol. 1999 Mar 01; 207(1):49-61. PMID: 10049564.
      Citations: 38     Fields:    Translation:AnimalsCells
    79. Evrard YA, Lun Y, Aulehla A, Gan L, Johnson RL. lunatic fringe is an essential mediator of somite segmentation and patterning. Nature. 1998 Jul 23; 394(6691):377-81. PMID: 9690473.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    80. Johnson RL. Low-dose dopamine and oxygen transport by the lung. Circulation. 1998 Jul 14; 98(2):97-9. PMID: 9679713.
      Citations:    Fields:    Translation:Humans
    81. Aszterbaum M, Rothman A, Johnson RL, Fisher M, Xie J, Bonifas JM, Zhang X, Scott MP, Epstein EH. Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol. 1998 Jun; 110(6):885-8. PMID: 9620294.
      Citations: 69     Fields:    Translation:HumansCells
    82. Kengaku M, Capdevila J, Rodriguez-Esteban C, De La Peña J, Johnson RL, Izpisúa Belmonte JC, Tabin CJ. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science. 1998 May 22; 280(5367):1274-7. PMID: 9596583.
      Citations: 85     Fields:    Translation:AnimalsCells
    83. Capdevila J, Johnson RL. Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning. Dev Biol. 1998 May 15; 197(2):205-17. PMID: 9630747.
      Citations: 26     Fields:    Translation:AnimalsCells
    84. Dreyer SD, Zhou G, Baldini A, Winterpacht A, Zabel B, Cole W, Johnson RL, Lee B. Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome. Nat Genet. 1998 May; 19(1):47-50. PMID: 9590287.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    85. Chen H, Lun Y, Ovchinnikov D, Kokubo H, Oberg KC, Pepicelli CV, Gan L, Lee B, Johnson RL. Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat Genet. 1998 May; 19(1):51-5. PMID: 9590288.
      Citations: 97     Fields:    Translation:HumansAnimals
    86. Morsli H, Choo D, Ryan A, Johnson R, Wu DK. Development of the mouse inner ear and origin of its sensory organs. J Neurosci. 1998 May 01; 18(9):3327-35. PMID: 9547240.
      Citations: 154     Fields:    Translation:Animals
    87. Capdevila J, Tabin C, Johnson RL. Control of dorsoventral somite patterning by Wnt-1 and beta-catenin. Dev Biol. 1998 Jan 15; 193(2):182-94. PMID: 9473323.
      Citations: 24     Fields:    Translation:AnimalsCells
    88. Chen H, Ovchinnikov D, Pressman CL, Aulehla A, Lun Y, Johnson RL. Multiple calvarial defects in lmx1b mutant mice. Dev Genet. 1998; 22(4):314-20. PMID: 9664684.
      Citations: 14     Fields:    Translation:Animals
    89. Cygan JA, Johnson RL, McMahon AP. Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec; 124(24):5021-32. PMID: 9362463.
      Citations: 23     Fields:    Translation:AnimalsCells
    90. Heanue TA, Johnson RL, Izpisua-Belmonte JC, Stern CD, De Robertis EM, Tabin CJ. Goosecoid misexpression alters the morphology and Hox gene expression of the developing chick limb bud. Mech Dev. 1997 Dec; 69(1-2):31-7. PMID: 9486529.
      Citations: 2     Fields:    Translation:AnimalsCells
    91. Wait JL, Johnson RL. Patterns of shortening and thickening of the human diaphragm. J Appl Physiol (1985). 1997 Oct; 83(4):1123-32. PMID: 9338420.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    92. Johnson RL, Tabin CJ. Molecular models for vertebrate limb development. Cell. 1997 Sep 19; 90(6):979-90. PMID: 9323126.
      Citations: 81     Fields:    Translation:Animals
    93. Newth CJ, Enright P, Johnson RL. Multiple-breath nitrogen washout techniques: including measurements with patients on ventilators. Eur Respir J. 1997 Sep; 10(9):2174-85. PMID: 9311523.
      Citations: 6     Fields:    Translation:Humans
    94. Johnson RL, Scott MP. Control of cell growth and fate by patched genes. Cold Spring Harb Symp Quant Biol. 1997; 62:205-15. PMID: 9598353.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    95. Marigo V, Johnson RL, Vortkamp A, Tabin CJ. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol. 1996 Nov 25; 180(1):273-83. PMID: 8948590.
      Citations: 81     Fields:    Translation:AnimalsCells
    96. Oh SH, Johnson R, Wu DK. Differential expression of bone morphogenetic proteins in the developing vestibular and auditory sensory organs. J Neurosci. 1996 Oct 15; 16(20):6463-75. PMID: 8815925.
      Citations: 32     Fields:    Translation:AnimalsCells
    97. Marigo V, Laufer E, Nelson CE, Riddle RD, Johnson RL, Tabin C. Sonic hedgehog regulates patterning in early embryos. Biochem Soc Symp. 1996; 62:51-60. PMID: 8971339.
      Citations: 1     Fields:    Translation:Animals
    98. Roberts DJ, Johnson RL, Burke AC, Nelson CE, Morgan BA, Tabin C. Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development. 1995 Oct; 121(10):3163-74. PMID: 7588051.
      Citations: 110     Fields:    Translation:AnimalsCells
    99. Levin M, Johnson RL, Stern CD, Kuehn M, Tabin C. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell. 1995 Sep 08; 82(5):803-14. PMID: 7671308.
      Citations: 129     Fields:    Translation:Animals
    100. Johnson RL, Tabin C. The long and short of hedgehog signaling. Cell. 1995 May 05; 81(3):313-6. PMID: 7736584.
      Citations: 17     Fields:    Translation:AnimalsCells
    101. Johnson RL, Laufer E, Riddle RD, Tabin C. Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites. Cell. 1994 Dec 30; 79(7):1165-73. PMID: 8001152.
      Citations: 54     Fields:    Translation:AnimalsCells
    102. Laufer E, Nelson CE, Johnson RL, Morgan BA, Tabin C. Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell. 1994 Dec 16; 79(6):993-1003. PMID: 8001146.
      Citations: 123     Fields:    Translation:AnimalsCells
    103. Johnson RL, Riddle RD, Laufer E, Tabin C. Sonic hedgehog: a key mediator of anterior-posterior patterning of the limb and dorso-ventral patterning of axial embryonic structures. Biochem Soc Trans. 1994 Aug; 22(3):569-74. PMID: 7821639.
      Citations: 13     Fields:    Translation:AnimalsCells
    104. Johnson RL, Riddle RD, Tabin CJ. Mechanisms of limb patterning. Curr Opin Genet Dev. 1994 Aug; 4(4):535-42. PMID: 7950321.
      Citations: 9     Fields:    Translation:AnimalsCells
    105. Fietz MJ, Concordet JP, Barbosa R, Johnson R, Krauss S, McMahon AP, Tabin C, Ingham PW. The hedgehog gene family in Drosophila and vertebrate development. Dev Suppl. 1994; 43-51. PMID: 7579523.
      Citations: 16     Fields:    Translation:AnimalsCells
    106. Riddle RD, Johnson RL, Laufer E, Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell. 1993 Dec 31; 75(7):1401-16. PMID: 8269518.
      Citations: 426     Fields:    Translation:AnimalsCells
    107. Johnson RL, Grant KB, Zankel TC, Boehm MF, Merbs SL, Nathans J, Nakanishi K. Cloning and expression of goldfish opsin sequences. Biochemistry. 1993 Jan 12; 32(1):208-14. PMID: 8418840.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    108. Yan B, Takahashi T, Johnson R, Spudich JL. Identification of signaling states of a sensory receptor by modulation of lifetimes of stimulus-induced conformations: the case of sensory rhodopsin II. Biochemistry. 1991 Nov 05; 30(44):10686-92. PMID: 1931988.
      Citations: 24     Fields:    Translation:Cells
    109. Takahashi T, Yoshihara K, Watanabe M, Kubota M, Johnson R, Derguini F, Nakanishi K. Photoisomerization of retinal at 13-ene is important for phototaxis of Chlamydomonas reinhardtii: simultaneous measurements of phototactic and photophobic responses. Biochem Biophys Res Commun. 1991 Aug 15; 178(3):1273-9. PMID: 1872847.
      Citations: 15     Fields:    Translation:AnimalsCells
    110. Corson DW, Cornwall MC, MacNichol EF, Jin J, Johnson R, Derguini F, Crouch RK, Nakanishi K. Sensitization of bleached rod photoreceptors by 11-cis-locked analogues of retinal. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6823-7. PMID: 2395874.
      Citations: 10     Fields:    Translation:AnimalsCells
    111. Yan B, Takahashi T, Johnson R, Derguini F, Nakanishi K, Spudich JL. All-trans/13-cis isomerization of retinal is required for phototaxis signaling by sensory rhodopsins in Halobacterium halobium. Biophys J. 1990 Apr; 57(4):807-14. PMID: 2344465.
      Citations: 12     Fields:    Translation:Cells
    112. Foster KW, Saranak J, Derguini F, Zarrilli GR, Johnson R, Okabe M, Nakanishi K. Activation of Chlamydomonas rhodopsin in vivo does not require isomerization of retinal. Biochemistry. 1989 Jan 24; 28(2):819-24. PMID: 2713348.
      Citations: 12     Fields:    Translation:AnimalsCells
    113. Norman AW, Johnson RL, Okamura WH. 24-Nor-25-hydroxyvitamin D3. A specific antagonist of vitamin D3 action in the chick. J Biol Chem. 1979 Nov 25; 254(22):11450-6. PMID: 500652.
      Citations:    Fields:    Translation:Animals
    114. Norman AW, Johnson RL, Corradino R, Okamura WH. Structure-function studies of the side chain of 25-hydroxyvitamin D3. J Biol Chem. 1979 Nov 25; 254(22):11445-9. PMID: 500651.
      Citations: 2     Fields:    Translation:Animals
    115. Ren P, Stark PY, Johnson RL, Bell RG. Mechanism of action of anticoagulants: correlation between the inhibition of prothrombin synthesis and the regeneration of vitamin K1 from vitamin K1 epoxide. J Pharmacol Exp Ther. 1977 Jun; 201(3):541-6. PMID: 864593.
      Citations: 3     Fields:    Translation:Animals
    116. Johnson RL, Carey SC, Norman AW, Okamura WH. Studies on vitamin D (calciferol) and its analogues. 10. Side-chain analogues of 25-hydroxyvitamin D3. J Med Chem. 1977 Jan; 20(1):5-11. PMID: 833826.
      Citations:    Fields:    Translation:Animals
    117. Norman AW, Okamura WH, Friedlander EJ, Henry HL, Johnson RL, Mitra MN, Proscal DA, Wecksler WW. Current concepts of the chemical conformation, metabolism, and interaction of the steroid, vitamin D, with the endocrine system for calcium homeostasis. Calcif Tissue Res. 1976 Aug; 21 Suppl:153-9. PMID: 182332.
      Citations:    Fields:    Translation:HumansAnimalsCells
    118. Norman AW, Johnson RL, Osborn TW, Procsal DA, Carey SC, Hammond ML, Mitra MN, Pirio MR, Rego A, Wing RM, Okamura WH. The chemistry and conformational and biological analysis of vitamin D3, its metabolites and analogues. Clin Endocrinol (Oxf). 1976; 5 Suppl:121S-143S. PMID: 212225.
      Citations: 1     Fields:    Translation:AnimalsCells
    119. Johnson RL, Okamura WH, Norman AW. Studies on the mode of action of calciferol. X. 24-Nor-25-hydroxyvitamin D3, an analog of 25-hydroxyvitamin D3 having "anti-vitamin" activity. Biochem Biophys Res Commun. 1975 Nov 17; 67(2):797-802. PMID: 173329.
      Citations: 1     Fields:    Translation:Animals
    120. HANLON S, LAMERS K, LAUTERBACH G, JOHNSON R, SCHACHMAN HK. Ultracentrifuge studies with absorption optics. I. An automatic photoelectric scanning absorption system. Arch Biochem Biophys. 1962 Oct; 99:157-74. PMID: 13952541.
      Citations: 6     Fields:    Translation:Humans
    121. Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons (Journal of Neuroscience (2008) (14097-14106)). Journal of Neuroscience. 29.
    122. Erratum. Development. 136:1961.
    123. ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer. Oncotarget. 6:25883-25896.
    124. An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2. Oncotarget. 7:24063-24075.
    125. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology.
    126. The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. Genes and Development. 30:786-797.
    127. The two faces of Hippo. Nature Reviews Drug Discovery. 13:63-79.
    128. Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus. Nature Communications. 7.
    129. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology. 63:159-172.
    130. The hedgehog gene family in Drosophila and vertebrate development. Development. 120:43-51.
    131. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nature Communications. 7.
    132. Hippo signaling and organ size control. 281-291.
    133. Bovine rhodopsin with 11-cis-locked retinal chromophore neither activates rhodopsin kinase nor undergoes conformational change upon irradiation. Journal of the American Chemical Society. 112:5387-5388.
    134. Study of the chemical conformation and interaction of the steroid hormone 1α,25 dihydroxyvitamin D3 and related analogues with the endocrine system for calcium homeostasis. Israel Journal of Medical Sciences. 12:1488.
    135. Inactivation of hippo pathway is significantly associated with poor prognosis in hepatocellular carcinoma. Clinical Cancer Research. 22:1256-1264.
    136. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics. 46:24-32.
    137. The hippo coactivator YAP1 mediates EGFR overexpression and confers chemoresistance in esophageal cancer. Clinical Cancer Research. 21:2580-2590.
    138. 24 Nor 25 hydroxy vitamin D3 a steroid capable of inhibiting the biological responses of vitamin D3. Clinical Research. 24.
    139. Theory of rhodopsin activation. Pure and Applied Chemistry. 61:361-364.
    140. Syntheses and biological activities of side chain analog of 25 hydroxy cholecalciferol (25 hydroxy vitamin D3). Federation Proceedings. 34.
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