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RAMA SOUNDARARAJAN

TitleAssistant Professor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers (Basel). 2019 May 24; 11(5). PMID: 31137625.
      View in: PubMed
    2. Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Pietila M, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA. GSK3ß regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Res. 2019 03 07; 21(1):37. PMID: 30845991.
      View in: PubMed
    3. Fukumoto J, Sidramagowda Patil S, Krishnamurthy S, Saji S, John I, Narala VR, Hernández-Cuervo H, Alleyn M, Breitzig MT, Galam L, Soundararajan R, Chaudhari UK, Hansen BC, Lockey RF, Kolliputi N. Altered expression of p63 isoforms and expansion of p63- and club cell secretory protein-positive epithelial cells in the lung as novel features of aging. Am J Physiol Cell Physiol. 2019 Apr 01; 316(4):C492-C508. PMID: 30649915.
      View in: PubMed
    4. Fukumoto J, Leung J, Cox R, Czachor A, Parthasarathy PT, Lagishetty V, Mandry M, Hosseinian N, Patel P, Perry B, Breitzig MT, Alleyn M, Failla A, Cho Y, Cooke AJ, Galam L, Soundararajan R, Sharma N, Lockey RF, Kolliputi N. Oxidative stress induces club cell proliferation and pulmonary fibrosis in Atp8b1 mutant mice. Aging (Albany NY). 2019 Jan 13; 11(1):209-229. PMID: 30636723.
      View in: PubMed
    5. Soundararajan R, Paranjape AN, Maity S, Aparicio A, Mani SA. EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers. Biochim Biophys Acta Rev Cancer. 2018 12; 1870(2):229-238. PMID: 29981816.
      View in: PubMed
    6. Soundararajan R, Aparicio AM, Logothetis CJ, Mani SA, Maity SN. Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. Front Oncol. 2018; 8:69. PMID: 29600194.
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    7. Narala VR, Fukumoto J, Hernández-Cuervo H, Patil SS, Krishnamurthy S, Breitzig M, Galam L, Soundararajan R, Lockey RF, Kolliputi N. Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L860-L870. PMID: 29388469.
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    8. Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9903-E9912. PMID: 29087350.
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    9. Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. 2017 Sep 12; 8(39):65548-65565. PMID: 29029452.
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    10. Fukumoto J, Soundararajan R, Leung J, Cox R, Mahendrasah S, Muthavarapu N, Herrin T, Czachor A, Tan LC, Hosseinian N, Patel P, Gone J, Breitzig MT, Cho Y, Cooke AJ, Galam L, Narala VR, Pathak Y, Lockey RF, Kolliputi N. The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis. Aging (Albany NY). 2016 11 29; 8(11):3091-3109. PMID: 27899769.
      View in: PubMed
    11. Soundararajan R, Stearns TM, Czachor A, Fukumoto J, Turn C, Westermann-Clark E, Breitzig M, Tan L, Lockey RF, King BL, Kolliputi N. Global gene profiling of aging lungs in Atp8b1 mutant mice. Aging (Albany NY). 2016 09 29; 8(9):2232-2252. PMID: 27689529.
      View in: PubMed
    12. Galam L, Soundararajan R, Breitzig M, Rajan A, Yeruva RR, Czachor A, Harris F, Lockey RF, Kolliputi N. SOCS-1 rescues IL-1ß-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1. Oncotarget. 2016 May 17; 7(20):29081-91. PMID: 27058411.
      View in: PubMed
    13. Pietilä M, Vijay GV, Soundararajan R, Yu X, Symmans WF, Sphyris N, Mani SA. FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition. Sci Rep. 2016 Apr 11; 6:23070. PMID: 27064522.
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    14. Galam L, Rajan A, Failla A, Soundararajan R, Lockey RF, Kolliputi N. Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L572-81. PMID: 26747786.
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    15. Galam L, Failla A, Soundararajan R, Lockey RF, Kolliputi N. 4-hydroxynonenal regulates mitochondrial function in human small airway epithelial cells. Oncotarget. 2015 Dec 08; 6(39):41508-21. PMID: 26484418.
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    16. Snyder E, Soundararajan R, Sharma M, Dearth A, Smith B, Braun RE. Compound Heterozygosity for Y Box Proteins Causes Sterility Due to Loss of Translational Repression. PLoS Genet. 2015 Dec; 11(12):e1005690. PMID: 26646932.
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    17. Soundararajan R, Stearns TM, Griswold AL, Mehta A, Czachor A, Fukumoto J, Lockey RF, King BL, Kolliputi N. Detection of canonical A-to-G editing events at 3' UTRs and microRNA target sites in human lungs using next-generation sequencing. Oncotarget. 2015 Nov 03; 6(34):35726-36. PMID: 26486088.
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    18. Soundararajan R, Paranjape AN, Barsan V, Chang JT, Mani SA. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Sci Rep. 2015 Jun 30; 5:11766. PMID: 26123483.
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    19. Soundararajan R, Won J, Stearns TM, Charette JR, Hicks WL, Collin GB, Naggert JK, Krebs MP, Nishina PM. Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs. PLoS One. 2014; 9(10):e110299. PMID: 25357075.
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    20. Naswa N, Karunanithi S, Sharma P, Soundararajan R, Bal C, Kumar R. Pre-operative 68Ga-DOTANOC somatostatin receptor PET/CT imaging demonstrating multiple synchronous lesions in a patient with head and neck paraganglioma. Rev Esp Med Nucl Imagen Mol. 2014 Nov-Dec; 33(6):374-7. PMID: 25043773.
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    21. Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE. Collecting duct principal cell transport processes and their regulation. Clin J Am Soc Nephrol. 2015 Jan 07; 10(1):135-46. PMID: 24875192.
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    22. Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012 Sep 21; 287(39):33014-25. PMID: 22851176.
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    23. Soundararajan R, Prabha P, Rai U, Dixit A. Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells. Evid Based Complement Alternat Med. 2012; 2012:732404. PMID: 22654956.
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    24. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun; 26(6):1000-13. PMID: 22556341.
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    25. Soundararajan R, Lu M, Pearce D. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012 Jul-Aug; 47(4):349-59. PMID: 22506713.
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    26. Soundararajan R, Pearce D, Ziera T. The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol. 2012 Mar 24; 350(2):242-7. PMID: 22101317.
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    27. Soundararajan R, Wang J, Melters D, Pearce D. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem. 2010 Dec 17; 285(51):39905-13. PMID: 20947508.
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    28. Soundararajan R, Pearce D, Hughey RP, Kleyman TR. Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem. 2010 Oct 01; 285(40):30363-9. PMID: 20624922.
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    29. Soundararajan R, Sayat R, Robertson GS, Marignani PA. Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells. Cancer Biol Ther. 2009 Nov; 8(21):2054-62. PMID: 19783906.
      View in: PubMed
    30. Neelima PS, Rao Rekha M, Rama S, Rao AJ. Effect of human telomerase reverse transcriptase transfection on differentiation in BeWo choriocarcinoma cells. Reprod Biomed Online. 2009 Jun; 18(6):838-49. PMID: 19490790.
      View in: PubMed
    31. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7804-9. PMID: 19380724.
      View in: PubMed
    32. Soundararajan R, Wishart AD, Rupasinghe HP, Arcellana-Panlilio M, Nelson CM, Mayne M, Robertson GS. Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. J Biol Chem. 2008 Jan 25; 283(4):2231-45. PMID: 18032389.
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    33. Soundararajan R, Wang J, Melters D, Pearce D. Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J Biol Chem. 2007 Dec 14; 282(50):36303-13. PMID: 17956870.
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    34. Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions. Am J Physiol Renal Physiol. 2007 Jun; 292(6):F1741-50. PMID: 17356130.
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    35. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F714-21. PMID: 16720863.
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    36. Yashwanth R, Rama S, Anbalagan M, Rao AJ. Role of estrogen in regulation of cellular differentiation: a study using human placental and rat Leydig cells. Mol Cell Endocrinol. 2006 Feb 26; 246(1-2):114-20. PMID: 16413111.
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    37. Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D. A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport. J Biol Chem. 2005 Dec 02; 280(48):39970-81. PMID: 16216878.
      View in: PubMed
    38. Rama S, Petrusz P, Rao AJ. Hormonal regulation of human trophoblast differentiation: a possible role for 17beta-estradiol and GnRH. Mol Cell Endocrinol. 2004 Apr 15; 218(1-2):79-94. PMID: 15130513.
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    39. Soundararajan R, Rao AJ. Trophoblast 'pseudo-tumorigenesis': significance and contributory factors. Reprod Biol Endocrinol. 2004 Mar 25; 2:15. PMID: 15043753.
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    40. Hamil KG, Liu Q, Sivashanmugam P, Anbalagan M, Yenugu S, Soundararajan R, Grossman G, Rao AJ, Birse CE, Ruben SM, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH. LCN6, a novel human epididymal lipocalin. Reprod Biol Endocrinol. 2003 Nov 14; 1:112. PMID: 14617364.
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    41. Rama S, Rao AJ. Regulation of growth and function of the human placenta. Mol Cell Biochem. 2003 Nov; 253(1-2):263-8. PMID: 14619978.
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    42. Rao RM, Rama S, Rao AJ. Changes in T-plastin expression with human trophoblast differentiation. Reprod Biomed Online. 2003 Sep; 7(2):235-42. PMID: 14567899.
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    43. Rama S, Suresh Y, Rao AJ. TGF beta1 induces multiple independent signals to regulate human trophoblastic differentiation: mechanistic insights. Mol Cell Endocrinol. 2003 Aug 29; 206(1-2):123-36. PMID: 12943995.
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    44. Hamil KG, Liu Q, Sivashanmugam P, Yenugu S, Soundararajan R, Grossman G, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH. Cystatin 11: a new member of the cystatin type 2 family. Endocrinology. 2002 Jul; 143(7):2787-96. PMID: 12072414.
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    45. Liu Q, Hamil KG, Sivashanmugam P, Grossman G, Soundararajan R, Rao AJ, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH. Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human. Endocrinology. 2001 Oct; 142(10):4529-39. PMID: 11564719.
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    46. Rama S, Suresh Y, Rao AJ. Regulation of telomerase during human placental differentiation: a role for TGFbeta1. Mol Cell Endocrinol. 2001 Sep; 182(2):233-48. PMID: 11514058.
      View in: PubMed
    47. Rama S, Rao AJ. Embryo implantation and GnRH antagonists: the search for the human placental GnRH receptor. Hum Reprod. 2001 Feb; 16(2):201-5. PMID: 11157806.
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    48. Vittal JP, Anantasubramaniam CR, Soundararajan R, Patil KC. Hydrazinium thiocyanate as a reagent for determination of copper. Talanta. 1979 Nov; 26(11):1041-2. PMID: 18962574.
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    49. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene.
    50. FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition. Scientific Reports. 6.
    51. Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties. Oncogene.
    52. Effects of ICI 182780 on estrogen receptor expression, fluid absorption and sperm motility in the epididymis of the bonnet monkey. Reproductive Biology and Endocrinology. 3.
    53. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Scientific Reports. 5.
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