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MIHAI GAGEA IURASCU

TitleAssociate Professor
InstitutionMD Anderson
DepartmentVeterinary Medicine & Surgery
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang J, Jiao J, Cermelli S, Muir K, Jung KH, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Res. 2015 May 01; 75(9):1859-67. PMID: 25769721.
      View in: PubMed
    2. Liu S, Meric-Bernstam F, Parinyanitikul N, Wang B, Eterovic AK, Zheng X, Gagea M, Chavez-MacGregor M, Ueno NT, Lei X, Zhou W, Nair L, Tripathy D, Brown PH, Hortobagyi GN, Chen K, Mendelsohn J, Mills GB, Gonzalez-Angulo AM. Functional consequence of the MET-T1010I polymorphism in breast cancer. Oncotarget. 2015 Feb 20; 6(5):2604-14. PMID: 25605252.
      View in: PubMed
    3. Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB. Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. Cancer Cell. 2014 Dec 08; 26(6):863-879. PMID: 25490449.
      View in: PubMed
    4. Henderson YC, Ahn SH, Ryu J, Chen Y, Williams MD, El-Naggar AK, Gagea M, Schweppe RE, Haugen BR, Lai SY, Clayman GL. Development and characterization of six new human papillary thyroid carcinoma cell lines. J Clin Endocrinol Metab. 2015 Feb; 100(2):E243-52. PMID: 25427145.
      View in: PubMed
    5. Mitra A, Satelli A, Yan J, Xueqing X, Gagea M, Hunter CA, Mishra L, Li S. IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice. Hepatology. 2014 Dec; 60(6):2027-39. PMID: 25351459.
      View in: PubMed
    6. Liu S, Meng X, Chen H, Liu W, Miller T, Murph M, Lu Y, Zhang F, Gagea M, Arteaga CL, Mills GB, Meric-Bernstam F, González-Angulo AM. Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer. Oncotarget. 2014 Oct 15; 5(19):9049-64. PMID: 24979294.
      View in: PubMed
    7. Tam AL, Abdelsalam ME, Gagea M, Ensor JE, Moussa M, Ahmed M, Goldberg SN, Dixon K, McWatters A, Miller JJ, Srimathveeravalli G, Solomon SB, Avritscher R, Wallace MJ, Gupta S. Irreversible electroporation of the lumbar vertebrae in a porcine model: is there clinical-pathologic evidence of neural toxicity? Radiology. 2014 Sep; 272(3):709-19. PMID: 24766034.
      View in: PubMed
    8. Zuo X, Xu M, Yu J, Wu Y, Moussalli MJ, Manyam GC, Lee SI, Liang S, Gagea M, Morris JS, Broaddus RR, Shureiqi I. Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-d/ß overexpression. J Natl Cancer Inst. 2014 Apr; 106(4):dju052. PMID: 24681603.
      View in: PubMed
    9. Agarwal NK, Zhu X, Gagea M, White CL, Cote G, Georgescu MM. PHLPP2 suppresses the NF-?B pathway by inactivating IKKß kinase. Oncotarget. 2014 Feb 15; 5(3):815-23. PMID: 24553260.
      View in: PubMed
    10. Panupinthu N, Yu S, Zhang D, Zhang F, Gagea M, Lu Y, Grandis JR, Dunn SE, Lee HY, Mills GB. Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer. Oncogene. 2014 May 29; 33(22):2846-56. PMID: 23851501.
      View in: PubMed
    11. Ravoori M, Duggal J, Gagea M, Han L, Singh S, Liu P, Wei W, Ragan DK, Bankson JA, Ma J, Kundra V. Visualizing the prostate gland by MR imaging in young and old mice. PLoS One. 2013; 8(3):e55746. PMID: 23469167.
      View in: PubMed
    12. Uthamanthil RK, Hachem RY, Gagea M, Reitzel RA, Borne AT, Tinkey PT. Urinary catheterization of male rabbits: a new technique and a review of urogenital anatomy. J Am Assoc Lab Anim Sci. 2013 Mar; 52(2):180-5. PMID: 23562102.
      View in: PubMed
    13. Zhu X, Morales FC, Agarwal NK, Dogruluk T, Gagea M, Georgescu MM. Moesin is a glioma progression marker that induces proliferation and Wnt/ß-catenin pathway activation via interaction with CD44. Cancer Res. 2013 Feb 01; 73(3):1142-55. PMID: 23221384.
      View in: PubMed
    14. Frank SJ, Johansen MJ, Martirosyan KS, Gagea M, Van Pelt CS, Borne A, Carmazzi Y, Madden T. A biodistribution and toxicity study of cobalt dichloride-N-acetyl cysteine in an implantable MRI marker for prostate cancer treatment. Int J Radiat Oncol Biol Phys. 2013 Mar 15; 85(4):1024-30. PMID: 23092727.
      View in: PubMed
    15. Liang ZD, Long Y, Tsai WB, Fu S, Kurzrock R, Gagea-Iurascu M, Zhang F, Chen HH, Hennessy BT, Mills GB, Savaraj N, Kuo MT. Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov; 11(11):2483-94. PMID: 22914438.
      View in: PubMed
    16. Di Domizio J, Dorta-Estremera S, Gagea M, Ganguly D, Meller S, Li P, Zhao B, Tan FK, Bi L, Gilliet M, Cao W. Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14550-5. PMID: 22904191.
      View in: PubMed
    17. Di Domizio J, Zhang R, Stagg LJ, Gagea M, Zhuo M, Ladbury JE, Cao W. Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid. J Biol Chem. 2012 Jan 02; 287(1):736-47. PMID: 22102410.
      View in: PubMed
    18. Avritscher R, Wright KC, Javadi S, Uthamanthil R, Gupta S, Gagea M, Bassett RL, Murthy R, Wallace MJ, Madoff DC. Development of a large animal model of cirrhosis and portal hypertension using hepatic transarterial embolization: a study in swine. J Vasc Interv Radiol. 2011 Sep; 22(9):1329-34. PMID: 21802316.
      View in: PubMed
    19. Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ. Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis. Cancer Prev Res (Phila). 2011 Jan; 4(1):51-64. PMID: 21098042.
      View in: PubMed
    20. Tan RH, Crisman MV, Clark SP, Gagea M, Zimmerman K. Multicentric mastocytoma in a horse. J Vet Intern Med. 2007 Mar-Apr; 21(2):340-3. PMID: 17427399.
      View in: PubMed
    21. Gagea MI, Bateman KG, Shanahan RA, van Dreumel T, McEwen BJ, Carman S, Archambault M, Caswell JL. Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves. J Vet Diagn Invest. 2006 Jan; 18(1):29-40. PMID: 16566255.
      View in: PubMed
    22. Gagea MI, Bateman KG, van Dreumel T, McEwen BJ, Carman S, Archambault M, Shanahan RA, Caswell JL. Diseases and pathogens associated with mortality in Ontario beef feedlots. J Vet Diagn Invest. 2006 Jan; 18(1):18-28. PMID: 16566254.
      View in: PubMed
    23. Wellehan JF, Gagea M, Smith DA, Taylor WM, Berhane Y, Bienzle D. Characterization of a herpesvirus associated with tracheitis in Gouldian finches (Erythrura [Chloebia] gouldiae). J Clin Microbiol. 2003 Sep; 41(9):4054-7. PMID: 12958225.
      View in: PubMed
    24. Lack of immunomodulatory interleukin-27 enhances oncogenic properties of mutant p53 in vivo. Clinical Cancer Research. 22:3876-3883.
    25. Ability to generate patient-derived Breast cancer xenografts is enhanced in chemoresistant disease and predicts poor patient outcomes. PLoS One. 10.
    26. Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis. Oncotarget. 6:38816-38826.
    27. A sucrose-enriched diet promotes tumorigenesis in mammary gland in part through the 12-lipoxygenase pathway. Cancer Research. 76:24-29.
    28. A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology.
    29. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene.
    30. Diaphragmatic hernia of the stomach with gastric rupture in a domestic pig. Comparative Medicine. 66:399-404.
    31. KLF4-mediated suppression of CD44 signaling negatively impacts pancreatic cancer stemness and metastasis. Cancer Research. 76:2419-2431.
    32. Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo. Leukemia.
    33. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene.
    34. NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia. Neoplasia (United States).
    35. Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nature Communications. 6.
    36. Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma. American Journal of Cancer Research. 5:3135-3148.
    37. Irreversible electroporation in the epidural space of the porcine spine. Radiology. 281:763-771.
    38. Corrigendum to "Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells". Journal of Hepatology.
    39. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell. 29:324-338.
    40. Euthanasia and Necropsy. 117-139.
    41. Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. Oncotarget. 7:53414-53429.
    42. Interleukin-30 (IL27p28) alleviates experimental sepsis by modulating cytokine profile in NKT cells. Journal of Hepatology.
    43. PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway. Investigational New Drugs.
    44. Differentiation therapy for hepatocellular carcinoma. Hepatology.
    45. Erratum. Nature Communications. 6.
    46. Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption. Genes and Cancer. 5:348-352.
    47. Erratum. PLoS One. 11.
    48. An advanced histologic method for evaluation of intestinal adenomas in mice using digital slides. PLoS One. 11.
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