Loading...
Header Logo
Keywords
Last Name
Institution

JIAN CHEN

TitleAssistant Professor
InstitutionMD Anderson
DepartmentGastroenterology Hepatology & Nutrition
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yin J, Ji F, Gharibani P, Chen JD. Vagal Nerve Stimulation for Glycemic Control in a Rodent Model of Type 2 Diabetes. Obes Surg. 2019 Sep; 29(9):2869-2877. PMID: 31222497.
      View in: PubMed
    2. Chen J, Gingold JA, Su X. Immunomodulatory TGF-ß Signaling in Hepatocellular Carcinoma. Trends Mol Med. 2019 Jul 25. PMID: 31353124.
      View in: PubMed
    3. Jiang L, Zhang N, Zhang S, Chen JD. Sacral nerve stimulation with optimized parameters improves visceral hypersensitivity in rats mediated via the autonomic pathway. Mol Pain. 2019 Jan-Dec; 15:1744806919880651. PMID: 31530213.
      View in: PubMed
    4. Ge Z, Duan Z, Yang H, Zhang S, Zhang S, Wang L, Yang D, Sun X, Zhang Z, Su L, Zhu H, Zhou D, Liu B, Shi H, Yu J, Yang H, Chang Q, Zhang N, Wu D, Chen JDZ. Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids. Evid Based Complement Alternat Med. 2018; 2018:2086163. PMID: 29853946.
      View in: PubMed
    5. Chen J, Herlong FH, Stroehlein JR, Mishra L. Mutations of Chromatin Structure Regulating Genes in Human Malignancies. Curr Protein Pept Sci. 2016; 17(5):411-37. PMID: 26796307.
      View in: PubMed
    6. Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014 Nov 14; 5:5384. PMID: 25395170.
      View in: PubMed
    7. Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst. 2014 Jul; 106(7). PMID: 24957076.
      View in: PubMed
    8. Zhang Y, Du S, Fang L, Yao S, Chen JD. Retrograde gastric electrical stimulation suppresses calorie intake in obese subjects. Obesity (Silver Spring). 2014 Jun; 22(6):1447-51. PMID: 24273197.
      View in: PubMed
    9. Katz LH, Li Y, Chen JS, Muñoz NM, Majumdar A, Chen J, Mishra L. Targeting TGF-ß signaling in cancer. Expert Opin Ther Targets. 2013 Jul; 17(7):743-60. PMID: 23651053.
      View in: PubMed
    10. Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle. 2012 Nov 15; 11(22):4181-90. PMID: 23095642.
      View in: PubMed
    11. Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):E1513-22. PMID: 22611192.
      View in: PubMed
    12. Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, Yeung SC, Lee MH. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3s. Oncogene. 2011 Dec 01; 30(48):4791-801. PMID: 21625211.
      View in: PubMed
    13. Feng YH, Velazquez-Torres G, Gully C, Chen J, Lee MH, Yeung SC. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med. 2011 Apr; 15(4):825-36. PMID: 20455996.
      View in: PubMed
    14. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011 Mar; 121(3):851-65. PMID: 21317535.
      View in: PubMed
    15. Zhao R, Fuentes-Mattei E, Velazquez-Torres G, Su CH, Chen J, Lee MH, Yeung SC. Exenatide improves glucocorticoid-induced glucose intolerance in mice. Diabetes Metab Syndr Obes. 2011 Jan 26; 4:61-5. PMID: 21448323.
      View in: PubMed
    16. Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH. 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res. 2011 Feb 01; 71(3):884-94. PMID: 21135113.
      View in: PubMed
    17. Su CH, Zhao R, Velazquez-Torres G, Chen J, Gully C, Yeung SC, Lee MH. Nuclear export regulation of COP1 by 14-3-3s in response to DNA damage. Mol Cancer. 2010 Sep 15; 9:243. PMID: 20843328.
      View in: PubMed
    18. Wang J, Song J, Hou X, Liu J, Chen JD. Effects of cutaneous gastric electrical stimulation on gastric emptying and postprandial satiety and fullness in lean and obese subjects. J Clin Gastroenterol. 2010 May-Jun; 44(5):335-9. PMID: 20195164.
      View in: PubMed
    19. Gully CP, Zhang F, Chen J, Yeung JA, Velazquez-Torres G, Wang E, Yeung SC, Lee MH. Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer. 2010 Feb 22; 9:42. PMID: 20175926.
      View in: PubMed
    20. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. Am J Pathol. 2009 Jul; 175(1):400-11. PMID: 19528349.
      View in: PubMed
    21. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH. Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene. 2009 Jul 16; 28(28):2581-92. PMID: 19483729.
      View in: PubMed
    22. Yin J, Chen JD. Roles of interstitial cells of Cajal in regulating gastrointestinal motility: in vitro versus in vivo studies. J Cell Mol Med. 2008 Aug; 12(4):1118-29. PMID: 18429936.
      View in: PubMed
    23. Zhang XC, Chen J, Su CH, Yang HY, Lee MH. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 2008 Mar 01; 103(4):1219-30. PMID: 17879958.
      View in: PubMed
    24. Yin J, Chen JDz. Excitatory effects of synchronized intestinal electrical stimulation on small intestinal motility in dogs. Am J Physiol Gastrointest Liver Physiol. 2007 Dec; 293(6):G1190-5. PMID: 17916650.
      View in: PubMed
    25. Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuchi T, Kobayashi M. All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors. J Immunol. 2007 Oct 01; 179(7):4616-25. PMID: 17878359.
      View in: PubMed
    26. Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui HY, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, Kobayashi M. Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. Cancer Gene Ther. 2007 Jan; 14(1):39-44. PMID: 16841081.
      View in: PubMed
    27. Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada J, Hattori Y, Kondo T, Hamuro J, Asaka M, Kobayashi M. Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells. Eur J Immunol. 2005 Dec; 35(12):3468-77. PMID: 16259004.
      View in: PubMed
    28. Suzuki A, Kusakai G, Shimojo Y, Chen J, Ogura T, Kobayashi M, Esumi H. Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation. J Biol Chem. 2005 Sep 09; 280(36):31557-63. PMID: 16014625.
      View in: PubMed
    29. Yao S, Ke M, Wang Z, Xu D, Zhang Y, Chen JD. Visceral sensitivity to gastric stimulation and its correlation with alterations in gastric emptying and accommodation in humans. Obes Surg. 2005 Feb; 15(2):247-53. PMID: 15802069.
      View in: PubMed
    30. Chiba K, Zhao W, Chen J, Wang J, Cui HY, Kawakami H, Miseki T, Satoshi H, Tanaka J, Asaka M, Kobayashi M. Neutrophils secrete MIP-1 beta after adhesion to laminin contained in basement membrane of blood vessels. Br J Haematol. 2004 Dec; 127(5):592-7. PMID: 15566363.
      View in: PubMed
    31. Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R, Kanangi R. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8132-7. PMID: 15141079.
      View in: PubMed
    32. Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, Sugiyama T, Hosokawa M, Kobayashi M. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol. 2003 Apr; 162(4):1283-91. PMID: 12651620.
      View in: PubMed
    33. Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M. Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis. Oncogene. 2003 Feb 27; 22(8):1238-42. PMID: 12606950.
      View in: PubMed
    34. Chen J. [Dominant negative HIF-1 alpha reduces tumorigenicity of a human pancreatic cancer cell line]. Hokkaido Igaku Zasshi. 2002 Jul; 77(4):367-78. PMID: 12187833.
      View in: PubMed
    35. Niizeki H, Kobayashi M, Horiuchi I, Akakura N, Chen J, Wang J, Hamada JI, Seth P, Katoh H, Watanabe H, Raz A, Hosokawa M. Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells. Br J Cancer. 2002 Jun 17; 86(12):1914-9. PMID: 12085186.
      View in: PubMed
    36. Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Hosokawa M, Asaka M. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res. 2001 Sep 01; 61(17):6548-54. PMID: 11522653.
      View in: PubMed
    37. Nature Communications. 6.
    38. The landscape of DNA virus associations across human cancers. 303-316.
    39. Mutations of chromatin structure regulating genes in human malignancies. Current Protein and Peptide Science. 17:411-437.
    40. Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption. Genes and Cancer. 5:348-352.
    41. TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. Journal of Clinical Investigation. 126:527-542.
    42. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 101:10494.
    43. Pathogenesis of hepatocellular carcinoma development in non-alcoholic fatty liver disease. Current Hepatitis Reports. 14:119-127.
    44. Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation. Scientific Reports. 6.
    45. CSN6 positively regulates c-jun in a MEKK1-dependent manner. Cell Cycle. 14:3079-3087.
    46. Mutational profiles reveal an aberrant TGF-β-CEA regulated pathway in colon adenomas. PLoS One. 11.
    CHEN's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description