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HUI-LIN PAN

TitleProfessor
InstitutionMD Anderson
DepartmentAnesthesiology & PeriOperative Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Deng M, Chen SR, Chen H, Pan HL. a2d-1-Bound N-Methyl-D-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents. Anesthesiology. 2019 May; 130(5):804-819. PMID: 30839350.
      View in: PubMed
    2. Huang Y, Chen SR, Chen H, Pan HL. Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. J Neurochem. 2019 May; 149(3):381-398. PMID: 30716174.
      View in: PubMed
    3. Deng M, Chen SR, Pan HL. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cell Mol Life Sci. 2019 May; 76(10):1889-1899. PMID: 30788514.
      View in: PubMed
    4. Sun J, Chen SR, Chen H, Pan HL. µ-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia. J Physiol. 2019 Mar; 597(6):1661-1675. PMID: 30578671.
      View in: PubMed
    5. Chen Y, Chen SR, Chen H, Zhang J, Pan HL. Increased a2d-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain. J Neurochem. 2019 Jan; 148(2):252-274. PMID: 30431158.
      View in: PubMed
    6. Deng M, Chen SR, Chen H, Luo Y, Dong Y, Pan HL. Mitogen-activated protein kinase signaling mediates opioid-induced presynaptic NMDA receptor activation and analgesic tolerance. J Neurochem. 2019 Jan; 148(2):275-290. PMID: 30444263.
      View in: PubMed
    7. Zhou JJ, Ma HJ, Shao JY, Pan HL, Li DP. Impaired Hypothalamic Regulation of Sympathetic Outflow in Primary Hypertension. Neurosci Bull. 2019 Feb; 35(1):124-132. PMID: 30506315.
      View in: PubMed
    8. Wang L, Chen SR, Ma H, Chen H, Hittelman WN, Pan HL. Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons. J Neurochem. 2018 Nov; 147(4):526-540. PMID: 30203849.
      View in: PubMed
    9. Zhang J, Chen SR, Chen H, Pan HL. RE1-silencing transcription factor controls the acute-to-chronic neuropathic pain transition and Chrm2 receptor gene expression in primary sensory neurons. J Biol Chem. 2018 12 07; 293(49):19078-19091. PMID: 30327427.
      View in: PubMed
    10. Luo Y, Ma H, Zhou JJ, Li L, Chen SR, Zhang J, Chen L, Pan HL. Focal Cerebral Ischemia and Reperfusion Induce Brain Injury Through a2d-1-Bound NMDA Receptors. Stroke. 2018 Oct; 49(10):2464-2472. PMID: 30355118.
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    11. Zhang J, Guan X, Li Q, Meredith AL, Pan HL, Yan J. Glutamate-activated BK channel complexes formed with NMDA receptors. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E9006-E9014. PMID: 30181277.
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    12. Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Jaubert J, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Gaitán-Peñas H, Guénet JL, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Estévez R, Pan HL, Geha RS, Shi Q, Benavides F. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight. 2018 Aug 23; 3(16). PMID: 30135305.
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    13. Ma H, Chen SR, Chen H, Zhou JJ, Li DP, Pan HL. a2d-1 couples to NMDA receptors in the hypothalamus to sustain sympathetic vasomotor activity in hypertension. J Physiol. 2018 Sep; 596(17):4269-4283. PMID: 29971791.
      View in: PubMed
    14. Ma H, Chen SR, Chen H, Li L, Li DP, Zhou JJ, Pan HL. a2d-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus. J Neurosci. 2018 Jul 11; 38(28):6388-6398. PMID: 29921713.
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    15. Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The a2d-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep. 2018 02 27; 22(9):2307-2321. PMID: 29490268.
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    16. Li DP, Zhou JJ, Zhang J, Pan HL. CaMKII Regulates Synaptic NMDA Receptor Activity of Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension. J Neurosci. 2017 11 01; 37(44):10690-10699. PMID: 28972129.
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    17. Li DP, Pan HL. Glutamatergic Regulation of Hypothalamic Presympathetic Neurons in Hypertension. Curr Hypertens Rep. 2017 Sep 19; 19(10):78. PMID: 28929331.
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    18. Chen SR, Jin XG, Pan HL. Endogenous nitric oxide inhibits spinal NMDA receptor activity and pain hypersensitivity induced by nerve injury. Neuropharmacology. 2017 Oct; 125:156-165. PMID: 28754372.
      View in: PubMed
    19. Xie JD, Chen SR, Chen H, Pan HL. Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord. Neuropharmacology. 2017 Sep 01; 123:477-487. PMID: 28663117.
      View in: PubMed
    20. Chen SR, Chen H, Zhou JJ, Pradhan G, Sun Y, Pan HL, Li DP. Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons. J Neurochem. 2017 08; 142(4):512-520. PMID: 28547758.
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    21. Qiao X, Zhou JJ, Li DP, Pan HL. Src Kinases Regulate Glutamatergic Input to Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension. Hypertension. 2017 01; 69(1):154-162. PMID: 27802416.
      View in: PubMed
    22. Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL. Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Rep. 2016 05 17; 15(7):1376-1383. PMID: 27160909.
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    23. Zhang Y, Chen SR, Laumet G, Chen H, Pan HL. Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of µ-Opioid Receptors in Primary Sensory Neurons. J Biol Chem. 2016 Apr 15; 291(16):8475-85. PMID: 26917724.
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    24. Zhu Y, Chen SR, Pan HL. Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. J Neurochem. 2016 Apr; 137(2):226-39. PMID: 26823384.
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    25. Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015 Dec; 18(12):1746-55. PMID: 26551542.
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    26. Zhou MH, Bavencoffe A, Pan HL. Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation. J Biol Chem. 2015 Dec 18; 290(51):30616-23. PMID: 26507659.
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    27. Li DP, Zhou JJ, Pan HL. Endogenous casein kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension. J Physiol. 2015 Oct 01; 593(19):4439-52. PMID: 26174743.
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    28. Zhang Y, Laumet G, Chen SR, Hittelman WN, Pan HL. Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development. J Biol Chem. 2015 Jun 05; 290(23):14647-55. PMID: 25925949.
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    29. Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol. 2014 Dec; 86(6):760-72. PMID: 25267719.
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    30. Chen SR, Zhu L, Chen H, Wen L, Laumet G, Pan HL. Increased spinal cord Na?-K?-2Cl? cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain. J Biol Chem. 2014 Nov 07; 289(45):31111-20. PMID: 25253692.
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    31. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 03; 83(5):1159-71. PMID: 25189211.
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    32. Chen SR, Zhou HY, Byun HS, Chen H, Pan HL. Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury. J Pharmacol Exp Ther. 2014 Aug; 350(2):301-12. PMID: 24898266.
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    33. Pachuau J, Li DP, Chen SR, Lee HA, Pan HL. Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. J Neurochem. 2014 Sep; 130(5):657-67. PMID: 24806793.
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    34. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem. 2014 May 16; 289(20):14321-30. PMID: 24695732.
      View in: PubMed
    35. Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL. mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats. J Neurosci. 2014 Mar 19; 34(12):4309-17. PMID: 24647951.
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    36. Hu YM, Chen SR, Chen H, Pan HL. Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. J Pharmacol Exp Ther. 2014 May; 349(2):239-47. PMID: 24610957.
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    37. Xia H, Zhang D, Yang S, Wang Y, Xu L, Wu J, Ren J, Yao W, Fan L, Zhang C, Tian Y, Pan HL, Wang X. Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain. Brain Res. 2014 Mar 20; 1554:29-35. PMID: 24480471.
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    38. Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci. 2014 Feb; 17(2):232-9. PMID: 24390226.
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    39. Bavencoffe A, Chen SR, Pan HL. Regulation of nociceptive transduction and transmission by nitric oxide. Vitam Horm. 2014; 96:1-18. PMID: 25189381.
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    40. Chen SR, Hu YM, Chen H, Pan HL. Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. J Physiol. 2014 Jan 01; 592(1):215-27. PMID: 24081160.
      View in: PubMed
    41. Petrov RR, Knight L, Chen SR, Wager-Miller J, McDaniel SW, Diaz F, Barth F, Pan HL, Mackie K, Cavasotto CN, Diaz P. Mastering tricyclic ring systems for desirable functional cannabinoid activity. Eur J Med Chem. 2013 Nov; 69:881-907. PMID: 24125850.
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    42. Chen SR, Zhou HY, Byun HS, Pan HL. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. J Pharmacol Exp Ther. 2013 Dec; 347(3):765-72. PMID: 24030012.
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    43. Ye ZY, Li DP, Pan HL. Regulation of Hypothalamic Presympathetic Neurons and Sympathetic Outflow by Group II Metabotropic Glutamate Receptors in Spontaneously Hypertensive Rats. Hypertension. 2013 Aug; 62(2):255-62. PMID: 23716583.
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    44. Guo YX, Li DP, Chen SR, Pan HL. Distinct intrinsic and synaptic properties of pre-sympathetic and pre-parasympathetic output neurons in Barrington's nucleus. J Neurochem. 2013 Aug; 126(3):338-48. PMID: 23647148.
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    45. Wu CH, Lv ZT, Zhao Y, Gao Y, Li JQ, Gao F, Meng XF, Tian B, Shi J, Pan HL, Li M. Electroacupuncture improves thermal and mechanical sensitivities in a rat model of postherpetic neuralgia. Mol Pain. 2013 Apr 03; 9:18. PMID: 23551937.
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    46. Cai YQ, Chen SR, Pan HL. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther. 2013 Apr; 345(1):161-8. PMID: 23386250.
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    47. Zhou HY, Chen SR, Byun HS, Chen H, Li L, Han HD, Lopez-Berestein G, Sood AK, Pan HL. N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain. J Biol Chem. 2012 Sep 28; 287(40):33853-64. PMID: 22854961.
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    48. Ye ZY, Li DP, Byun HS, Li L, Pan HL. NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension. J Neurosci. 2012 Jun 20; 32(25):8560-8. PMID: 22723696.
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    49. Zhao YL, Chen SR, Chen H, Pan HL. Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: implications for opioid hyperalgesia and tolerance. J Biol Chem. 2012 Jul 20; 287(30):25073-85. PMID: 22679016.
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    50. Xiong W, Cui T, Cheng K, Yang F, Chen SR, Willenbring D, Guan Y, Pan HL, Ren K, Xu Y, Zhang L. Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors. J Exp Med. 2012 Jun 04; 209(6):1121-34. PMID: 22585736.
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    51. Cao XH, Chen SR, Li L, Pan HL. Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons. J Neurochem. 2012 Jun; 121(6):944-53. PMID: 22428625.
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    52. Ye ZY, Li L, Li DP, Pan HL. Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension. J Biol Chem. 2012 May 18; 287(21):17438-46. PMID: 22474321.
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    53. Li DP, Byan HS, Pan HL. Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension. J Neurosci. 2012 Jan 04; 32(1):372-80. PMID: 22219297.
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    54. Li L, Cao XH, Chen SR, Han HD, Lopez-Berestein G, Sood AK, Pan HL. Up-regulation of Cavß3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. J Biol Chem. 2012 Feb 17; 287(8):6002-13. PMID: 22187436.
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    55. Su TF, Zhang LH, Peng M, Wu CH, Pan W, Tian B, Shi J, Pan HL, Li M. Cannabinoid CB2 receptors contribute to upregulation of ß-endorphin in inflamed skin tissues by electroacupuncture. Mol Pain. 2011 Dec 19; 7:98. PMID: 22177137.
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    56. Chen Z, Yoo SH, Park YS, Kim KH, Wei S, Buhr E, Ye ZY, Pan HL, Takahashi JS. Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):101-6. PMID: 22184224.
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    57. Cao XH, Byun HS, Chen SR, Pan HL. Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons. J Neurochem. 2011 Nov; 119(3):594-603. PMID: 21883220.
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    58. Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. J Biol Chem. 2011 Sep 23; 286(38):33190-202. PMID: 21813646.
      View in: PubMed
    59. Ye ZY, Li DP, Li L, Pan HL. Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension. J Neurosci. 2011 Jun 01; 31(22):8271-9. PMID: 21632948.
      View in: PubMed
    60. Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol. 2011 May; 4(3):379-88. PMID: 21686074.
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    61. Chen SR, Chen H, Yuan WX, Pan HL. Increased presynaptic and postsynaptic a2-adrenoceptor activity in the spinal dorsal horn in painful diabetic neuropathy. J Pharmacol Exp Ther. 2011 Apr; 337(1):285-92. PMID: 21248068.
      View in: PubMed
    62. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. J Biol Chem. 2010 Dec 24; 285(52):40427-37. PMID: 20940295.
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    63. Zhou HY, Chen SR, Chen H, Pan HL. Functional plasticity of group II metabotropic glutamate receptors in regulating spinal excitatory and inhibitory synaptic input in neuropathic pain. J Pharmacol Exp Ther. 2011 Jan; 336(1):254-64. PMID: 20923868.
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    64. Cao XH, Byun HS, Chen SR, Cai YQ, Pan HL. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. J Neurochem. 2010 Sep 01; 114(5):1460-75. PMID: 20557422.
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    65. Zhang J, Chen L, Su T, Cao F, Meng X, Pei L, Shi J, Pan HL, Li M. Electroacupuncture increases CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflamed skin tissues of rats. J Pain. 2010 Dec; 11(12):1250-8. PMID: 20627823.
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    66. Li DP, Pan HL. Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension. Am J Physiol Regul Integr Comp Physiol. 2010 Aug; 299(2):R552-61. PMID: 20519363.
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    67. Zhou HY, Chen SR, Chen H, Pan HL. Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci. 2010 Mar 24; 30(12):4460-6. PMID: 20335482.
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    68. Li DP, Chen SR, Pan HL. Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. J Neurochem. 2010 Apr; 113(2):530-42. PMID: 20096091.
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    69. Li DP, Pan HL. Role of GABAB receptors in autonomic control of systemic blood pressure. Adv Pharmacol. 2010; 58:257-86. PMID: 20655486.
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    70. Wu ZZ, Li DP, Chen SR, Pan HL. Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit. J Biol Chem. 2009 Dec 25; 284(52):36453-61. PMID: 19850918.
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    71. Li JQ, Chen SR, Chen H, Cai YQ, Pan HL. Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J Neurochem. 2010 Jan; 112(1):162-72. PMID: 19840219.
      View in: PubMed
    72. Cai YQ, Chen SR, Han HD, Sood AK, Lopez-Berestein G, Pan HL. Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. J Neurochem. 2009 Nov; 111(4):1000-10. PMID: 19780895.
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    73. Sun H, Li DP, Chen SR, Hittelman WN, Pan HL. Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors. J Pharmacol Exp Ther. 2009 Dec; 331(3):851-9. PMID: 19726694.
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    74. Chen SR, Samoriski G, Pan HL. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology. 2009 Aug; 57(2):121-6. PMID: 19422840.
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    75. Chen L, Zhang J, Li F, Qiu Y, Wang L, Li YH, Shi J, Pan HL, Li M. Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats. J Pain. 2009 Jul; 10(7):732-9. PMID: 19409856.
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    76. Chen SR, Cai YQ, Pan HL. Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain. J Neurochem. 2009 Jul; 110(1):352-62. PMID: 19457113.
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    77. Wu ZZ, Cai YQ, Pan HL. A functional link between T-type calcium channels and mu-opioid receptor expression in adult primary sensory neurons. J Neurochem. 2009 May; 109(3):867-78. PMID: 19250340.
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    78. Zhang HM, Chen SR, Cai YQ, Richardson TE, Driver LC, Lopez-Berestein G, Pan HL. Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord. Neuroscience. 2009 Feb 18; 158(4):1577-88. PMID: 19110040.
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    79. Yuan WX, Chen SR, Chen H, Pan HL. Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience. 2009 Feb 18; 158(4):1616-24. PMID: 19068225.
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    80. Zhou HY, Chen SR, Chen H, Pan HL. The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. J Neurochem. 2009 Jan; 108(1):305-18. PMID: 19012737.
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    81. Zhang HM, Chen SR, Pan HL. Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience. 2009 Jan 23; 158(2):875-84. PMID: 19017536.
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    82. Zhou HY, Chen SR, Chen H, Pan HL. Sustained inhibition of neurotransmitter release from nontransient receptor potential vanilloid type 1-expressing primary afferents by mu-opioid receptor activation-enkephalin in the spinal cord. J Pharmacol Exp Ther. 2008 Nov; 327(2):375-82. PMID: 18669865.
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    83. Li DP, Yang Q, Pan HM, Pan HL. Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H807-15. PMID: 18567709.
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    84. Chen SR, Pan HL. Removing TRPV1-expressing primary afferent neurons potentiates the spinal analgesic effect of delta-opioid agonists on mechano-nociception. Neuropharmacology. 2008 Aug; 55(2):215-22. PMID: 18579164.
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    85. Wu ZZ, Chen SR, Pan HL. Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents. Neuroscience. 2008 Jun 02; 153(4):1256-67. PMID: 18434033.
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    86. Li DP, Yang Q, Pan HM, Pan HL. Pre- and postsynaptic plasticity underlying augmented glutamatergic inputs to hypothalamic presympathetic neurons in spontaneously hypertensive rats. J Physiol. 2008 Mar 15; 586(6):1637-47. PMID: 18238817.
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    87. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. J Pharmacol Exp Ther. 2008 Mar; 324(3):1000-10. PMID: 18079355.
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    88. Pan HL, Wu ZZ, Zhou HY, Chen SR, Zhang HM, Li DP. Modulation of pain transmission by G-protein-coupled receptors. Pharmacol Ther. 2008 Jan; 117(1):141-61. PMID: 17959251.
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    89. Zhang HM, Zhou HY, Chen SR, Gautam D, Wess J, Pan HL. Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice. J Pharmacol Exp Ther. 2007 Dec; 323(3):963-71. PMID: 17878406.
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    90. Yang Q, Chen SR, Li DP, Pan HL. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Neuroscience. 2007 Oct 26; 149(2):315-27. PMID: 17869444.
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    91. Wu ZZ, Pan HL. Role of TRPV1 and intracellular Ca2+ in excitation of cardiac sensory neurons by bradykinin. Am J Physiol Regul Integr Comp Physiol. 2007 Jul; 293(1):R276-83. PMID: 17491115.
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    92. Chen SR, Pan HM, Richardson TE, Pan HL. Potentiation of spinal alpha(2)-adrenoceptor analgesia in rats deficient in TRPV1-expressing afferent neurons. Neuropharmacology. 2007 Jun; 52(8):1624-30. PMID: 17482651.
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    93. Li DP, Pan HL. Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension. Hypertension. 2007 Apr; 49(4):916-25. PMID: 17309953.
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    94. Chen Q, Pan HL. Signaling mechanisms of angiotensin II-induced attenuation of GABAergic input to hypothalamic presympathetic neurons. J Neurophysiol. 2007 May; 97(5):3279-87. PMID: 17287434.
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    95. Chen SR, Prunean A, Pan HM, Welker KL, Pan HL. Resistance to morphine analgesic tolerance in rats with deleted transient receptor potential vanilloid type 1-expressing sensory neurons. Neuroscience. 2007 Mar 16; 145(2):676-85. PMID: 17239544.
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    96. Wang XL, Zhang HM, Chen SR, Pan HL. Altered synaptic input and GABAB receptor function in spinal superficial dorsal horn neurons in rats with diabetic neuropathy. J Physiol. 2007 Mar 15; 579(Pt 3):849-61. PMID: 17218355.
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    97. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate. J Neurophysiol. 2007 Jan; 97(1):871-82. PMID: 17108089.
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    98. Li DP, Pan HL. Role of gamma-aminobutyric acid (GABA)A and GABAB receptors in paraventricular nucleus in control of sympathetic vasomotor tone in hypertension. J Pharmacol Exp Ther. 2007 Feb; 320(2):615-26. PMID: 17071818.
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    99. Zhang HM, Chen SR, Pan HL. Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. J Neurophysiol. 2007 Jan; 97(1):102-9. PMID: 17050831.
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    100. Zahner MR, Li DP, Pan HL. Benzodiazepine inhibits hypothalamic presympathetic neurons by potentiation of GABAergic synaptic input. Neuropharmacology. 2007 Feb; 52(2):467-75. PMID: 17045312.
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    101. Chen Q, Pan HL. Regulation of synaptic input to hypothalamic presympathetic neurons by GABA(B) receptors. Neuroscience. 2006 Oct 13; 142(2):595-606. PMID: 16887273.
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    102. Wu ZZ, Chen SR, Pan HL. Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. Neuroscience. 2006 Aug 11; 141(1):407-19. PMID: 16678970.
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    103. Chen SR, Pan HL. Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids. Brain Res. 2006 Apr 07; 1081(1):119-25. PMID: 16499888.
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    104. Chen SR, Pan HL. Loss of TRPV1-expressing sensory neurons reduces spinal mu opioid receptors but paradoxically potentiates opioid analgesia. J Neurophysiol. 2006 May; 95(5):3086-96. PMID: 16467418.
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    105. Wang XL, Zhang HM, Li DP, Chen SR, Pan HL. Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats. J Physiol. 2006 Mar 01; 571(Pt 2):403-13. PMID: 16410279.
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    106. Zhang HM, Chen SR, Matsui M, Gautam D, Wess J, Pan HL. Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Mol Pharmacol. 2006 Mar; 69(3):1048-55. PMID: 16365281.
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    107. Finnegan TF, Chen SR, Pan HL. Mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/1.2 channels. J Neurophysiol. 2006 Apr; 95(4):2032-41. PMID: 16306173.
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    108. Chen Q, Li DP, Pan HL. Presynaptic alpha1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons. J Pharmacol Exp Ther. 2006 Feb; 316(2):733-42. PMID: 16249372.
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    109. Li DP, Pan HL. Plasticity of GABAergic control of hypothalamic presympathetic neurons in hypertension. Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H1110-9. PMID: 16243912.
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    110. Chen YP, Chen SR, Pan HL. Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. J Pharmacol Exp Ther. 2005 Nov; 315(2):696-703. PMID: 16033910.
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    111. Chen SR, Pan HL. Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Res. 2005 Apr 25; 1042(1):108-13. PMID: 15823259.
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    112. Chen YP, Chen SR, Pan HL. Systemic morphine inhibits dorsal horn projection neurons through spinal cholinergic system independent of descending pathways. J Pharmacol Exp Ther. 2005 Aug; 314(2):611-7. PMID: 15845859.
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    113. Wu ZZ, Chen SR, Pan HL. Transient receptor potential vanilloid type 1 activation down-regulates voltage-gated calcium channels through calcium-dependent calcineurin in sensory neurons. J Biol Chem. 2005 May 06; 280(18):18142-51. PMID: 15746091.
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    114. Li DP, Pan HL. Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neurons. J Pharmacol Exp Ther. 2005 Jun; 313(3):1035-45. PMID: 15681656.
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    115. Chen SR, Wess J, Pan HL. Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice. J Pharmacol Exp Ther. 2005 May; 313(2):765-70. PMID: 15665136.
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    116. Vydyanathan A, Wu ZZ, Chen SR, Pan HL. A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons. J Neurophysiol. 2005 Jun; 93(6):3401-9. PMID: 15647393.
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    117. Zhang HM, Li DP, Chen SR, Pan HL. M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. J Pharmacol Exp Ther. 2005 May; 313(2):697-704. PMID: 15640398.
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    118. Wu ZZ, Pan HL. Tetrodotoxin-sensitive and -resistant Na+ channel currents in subsets of small sensory neurons of rats. Brain Res. 2004 Dec 17; 1029(2):251-8. PMID: 15542080.
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    119. Zahner MR, Pan HL. Role of paraventricular nucleus in the cardiogenic sympathetic reflex in rats. Am J Physiol Regul Integr Comp Physiol. 2005 Feb; 288(2):R420-6. PMID: 15472008.
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    120. Pan HL. Brain angiotensin II and synaptic transmission. Neuroscientist. 2004 Oct; 10(5):422-31. PMID: 15359009.
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    121. Finnegan TF, Chen SR, Pan HL. Effect of the {mu} opioid on excitatory and inhibitory synaptic inputs to periaqueductal gray-projecting neurons in the amygdala. J Pharmacol Exp Ther. 2005 Feb; 312(2):441-8. PMID: 15388784.
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    122. Chen SR, Pan HL. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan; 312(1):120-6. PMID: 15375175.
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    123. Wu ZZ, Pan HL. High voltage-activated Ca(2+) channel currents in isolectin B(4)-positive and -negative small dorsal root ganglion neurons of rats. Neurosci Lett. 2004 Sep 16; 368(1):96-101. PMID: 15342142.
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    124. Pan HL, Chen SR. Sensing tissue ischemia: another new function for capsaicin receptors? Circulation. 2004 Sep 28; 110(13):1826-31. PMID: 15364816.
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    125. Li DP, Atnip LM, Chen SR, Pan HL. Regulation of synaptic inputs to paraventricular-spinal output neurons by alpha2 adrenergic receptors. J Neurophysiol. 2005 Jan; 93(1):393-402. PMID: 15356178.
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    126. Wu ZZ, Chen SR, Pan HL. Differential sensitivity of N- and P/Q-type Ca2+ channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neurons. J Pharmacol Exp Ther. 2004 Dec; 311(3):939-47. PMID: 15280436.
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    127. Li DP, Chen SR, Pan HL. VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus. J Neurophysiol. 2004 Sep; 92(3):1807-16. PMID: 15115794.
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    128. Pan YZ, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors excites a population of locus coeruleus-spinal neurons through presynaptic disinhibition. Brain Res. 2004 Jan 30; 997(1):67-78. PMID: 14715151.
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    129. Pan YZ, Pan HL. Primary afferent stimulation differentially potentiates excitatory and inhibitory inputs to spinal lamina II outer and inner neurons. J Neurophysiol. 2004 Jun; 91(6):2413-21. PMID: 14749303.
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    130. Finnegan TF, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons. J Pharmacol Exp Ther. 2004 May; 309(2):476-83. PMID: 14724227.
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    131. Chen SR, Pan HL. Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors. Neuroscience. 2004; 125(1):141-8. PMID: 15051153.
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    132. Li DP, Chen SR, Finnegan TF, Pan HL. Signalling pathway of nitric oxide in synaptic GABA release in the rat paraventricular nucleus. J Physiol. 2004 Jan 01; 554(Pt 1):100-10. PMID: 14678495.
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    133. Chen SR, Pan HL. Antinociceptive effect of morphine, but not mu opioid receptor number, is attenuated in the spinal cord of diabetic rats. Anesthesiology. 2003 Dec; 99(6):1409-14. PMID: 14639157.
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    134. Chen SR, Pan HL. Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats. J Pharmacol Exp Ther. 2003 Nov; 307(2):676-81. PMID: 12966147.
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    135. Zahner MR, Li DP, Chen SR, Pan HL. Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol. 2003 Sep 01; 551(Pt 2):515-23. PMID: 12829722.
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    136. Li DP, Chen SR, Pan HL. Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. J Neurosci. 2003 Jun 15; 23(12):5041-9. PMID: 12832527.
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    137. Pan HL, Khan GM, Alloway KD, Chen SR. Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action. J Neurosci. 2003 Apr 01; 23(7):2911-9. PMID: 12684478.
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    138. Chen SR, Pan HL. Spinal GABAB receptors mediate antinociceptive actions of cholinergic agents in normal and diabetic rats. Brain Res. 2003 Mar 07; 965(1-2):67-74. PMID: 12591121.
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    139. Li X, Conklin D, Pan HL, Eisenach JC. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun; 305(3):950-5. PMID: 12606636.
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    140. Chen SR, Pan HL. Spinal nitric oxide contributes to the analgesic effect of intrathecal [d-pen2,d-pen5]-enkephalin in normal and diabetic rats. Anesthesiology. 2003 Jan; 98(1):217-22. PMID: 12503000.
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    141. Chen SR, Sweigart KL, Lakoski JM, Pan HL. Functional mu opioid receptors are reduced in the spinal cord dorsal horn of diabetic rats. Anesthesiology. 2002 Dec; 97(6):1602-8. PMID: 12459691.
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    142. Khan GM, Li DP, Chen SR, Pan HL. Role of spinal nitric oxide in the inhibitory effect of [D-Pen2, D-Pen5]-enkephalin on ascending dorsal horn neurons in normal and diabetic rats. J Pharmacol Exp Ther. 2002 Dec; 303(3):1021-8. PMID: 12438523.
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    143. Pan YZ, Li DP, Chen SR, Pan HL. Activation of delta-opioid receptors excites spinally projecting locus coeruleus neurons through inhibition of GABAergic inputs. J Neurophysiol. 2002 Nov; 88(5):2675-83. PMID: 12424303.
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    144. Li DP, Chen SR, Pan HL. Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release. J Neurophysiol. 2002 Nov; 88(5):2664-74. PMID: 12424302.
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    145. Li DP, Chen SR, Pan YZ, Levey AI, Pan HL. Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats. J Physiol. 2002 Sep 15; 543(Pt 3):807-18. PMID: 12231640.
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    146. Chen SR, Pan HL. Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats. J Neurophysiol. 2002 Jun; 87(6):2726-33. PMID: 12037174.
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    147. Pan YZ, Li DP, Pan HL. Inhibition of glutamatergic synaptic input to spinal lamina II(o) neurons by presynaptic alpha(2)-adrenergic receptors. J Neurophysiol. 2002 Apr; 87(4):1938-47. PMID: 11929913.
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    148. Sandner-Kiesling A, Pan HL, Chen SR, James RL, DeHaven-Hudkins DL, Dewan DM, Eisenach JC. Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain. 2002 Mar; 96(1-2):13-22. PMID: 11932057.
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    149. Pan HL, Chen SR. Myocardial ischemia recruits mechanically insensitive cardiac sympathetic afferents in cats. J Neurophysiol. 2002 Feb; 87(2):660-8. PMID: 11826035.
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    150. Chen SR, Wozniak KM, Slusher BS, Pan HL. Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. J Pharmacol Exp Ther. 2002 Feb; 300(2):662-7. PMID: 11805230.
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    151. Khan GM, Chen SR, Pan HL. Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats. Neuroscience. 2002; 114(2):291-9. PMID: 12204199.
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    152. Chen SR, Xu Z, Pan HL. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. Anesthesiology. 2001 Dec; 95(6):1473-9. PMID: 11748408.
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    153. Li DP, Pan YZ, Pan HL. Acetylcholine attenuates synaptic GABA release to supraoptic neurons through presynaptic nicotinic receptors. Brain Res. 2001 Nov 30; 920(1-2):151-8. PMID: 11716821.
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    154. Li DP, Pan HL. Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors. Am J Physiol Regul Integr Comp Physiol. 2001 Oct; 281(4):R1105-13. PMID: 11557616.
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    155. Chen SR, Khan GM, Pan HL. Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain. Anesthesiology. 2001 Oct; 95(4):1007-12. PMID: 11605898.
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    156. Li DP, Averill DB, Pan HL. Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex. Am J Physiol Regul Integr Comp Physiol. 2001 Sep; 281(3):R935-43. PMID: 11507011.
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    157. Pan HL, Xu Z, Leung E, Eisenach JC. Allosteric adenosine modulation to reduce allodynia. Anesthesiology. 2001 Aug; 95(2):416-20. PMID: 11506115.
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    158. Chen SR, Pan HL. Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology. 2001 Aug; 95(2):525-30. PMID: 11506129.
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    159. Gokin AP, Fareed MU, Pan HL, Hans G, Strichartz GR, Davar G. Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats. J Neurosci. 2001 Jul 15; 21(14):5358-66. PMID: 11438612.
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    160. Pan HL, Deal DD, Xu Z, Chen SR. Differential responses of regional sympathetic activity and blood flow to visceral afferent stimulation. Am J Physiol Regul Integr Comp Physiol. 2001 Jun; 280(6):R1781-9. PMID: 11353683.
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    161. Maher CE, Eisenach JC, Pan HL, Xiao R, Childers SR. Chronic intrathecal morphine administration produces homologous mu receptor/G-protein desensitization specifically in spinal cord. Brain Res. 2001 Mar 23; 895(1-2):1-8. PMID: 11259753.
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    162. Li DP, Pan HL. Responses of neurons in rostral ventrolateral medulla to activation of cardiac receptors in rats. Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):H2549-57. PMID: 11045993.
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    163. Li X, Rose G, Dongre N, Pan HL, Tobin JR, Eisenach JC. S-nitroso-l-cysteine releases norepinephrine in rat spinal synaptosomes. Brain Res. 2000 Jul 28; 872(1-2):301-7. PMID: 10924712.
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    164. Pan HL, Chen SR, Scicli GM, Carretero OA. Cardiac interstitial bradykinin release during ischemia is enhanced by ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2000 Jul; 279(1):H116-21. PMID: 10899048.
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    165. Li X, Zhao Z, Pan HL, Eisenach JC, Paqueron X. Norepinephrine release from spinal synaptosomes: auto-alpha2 -adrenergic receptor modulation. Anesthesiology. 2000 Jul; 93(1):164-72. PMID: 10861160.
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    166. Xu Z, Chen SR, Eisenach J, Pan HL. Role of spinal muscarinic and nicotinic receptors in clonidine-induced nitric oxide release in a rat model of neuropathic pain. Brain Res. 2000 Apr 10; 861(2):390-8. PMID: 10760500.
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    167. Cheng JK, Pan HL, Eisenach JC. Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain. Anesthesiology. 2000 Apr; 92(4):1126-31. PMID: 10754633.
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    168. Li X, Rose G, Chiari A, Pan HL, Tobin JR, Eisenach JC. 6-NO(2)-norepinephrine increases norepinephrine release and inhibits norepinephrine uptake in rat spinal synaptosomes. J Pharmacol Exp Ther. 2000 Mar; 292(3):895-9. PMID: 10688602.
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    169. Chen SR, Eisenach JC, McCaslin PP, Pan HL. Synergistic effect between intrathecal non-NMDA antagonist and gabapentin on allodynia induced by spinal nerve ligation in rats. Anesthesiology. 2000 Feb; 92(2):500-6. PMID: 10691238.
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    170. Zhao Z, Chen SR, Eisenach JC, Busija DW, Pan HL. Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. Neuroscience. 2000; 97(4):743-8. PMID: 10842019.
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    171. Chiari A, Li XH, Xu Z, Pan HL, Eisenach JC. Formation of 6-nitro-norepinephrine from nitric oxide and norepinephrine in the spinal cord and its role in spinal analgesia. Neuroscience. 2000; 101(1):189-96. PMID: 11068147.
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    172. Chen SR, Eisenach JC, Pan HL. Intrathecal S-nitroso-N-acetylpenicillamine and L-cysteine attenuate nerve injury-induced allodynia through noradrenergic activation in rats. Neuroscience. 2000; 101(3):759-65. PMID: 11113324.
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    173. Eisenach JC, Lavand'homme P, Tong C, Cheng JK, Pan HL, Virtanen R, Nikkanen H, James R. Antinociceptive and hemodynamic effects of a novel alpha2-adrenergic agonist, MPV-2426, in sheep. Anesthesiology. 1999 Nov; 91(5):1425-36. PMID: 10551595.
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    174. Chiari A, Tobin JR, Pan HL, Hood DD, Eisenach JC. Sex differences in cholinergic analgesia I: a supplemental nicotinic mechanism in normal females. Anesthesiology. 1999 Nov; 91(5):1447-54. PMID: 10551597.
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    175. Gomes JA, Li X, Pan HL, Eisenach JC. Intrathecal adenosine interacts with a spinal noradrenergic system to produce antinociception in nerve-injured rats. Anesthesiology. 1999 Oct; 91(4):1072-9. PMID: 10519511.
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    176. Pan HL, Longhurst JC, Eisenach JC, Chen SR. Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats. J Physiol. 1999 Aug 01; 518 ( Pt 3):857-66. PMID: 10420020.
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    177. Pan HL, Eisenach JC, Chen SR. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther. 1999 Mar; 288(3):1026-30. PMID: 10027839.
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    178. Pan HL, Chen SR, Eisenach JC. Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors. Anesthesiology. 1999 Feb; 90(2):509-14. PMID: 9952159.
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    179. Pan HL, Chen SR, Eisenach JC. Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats. Anesthesiology. 1998 Dec; 89(6):1518-23. PMID: 9856728.
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    180. Lavand'homme P, Pan HL, Eisenach JC. Intrathecal neostigmine, but not sympathectomy, relieves mechanical allodynia in a rat model of neuropathic pain. Anesthesiology. 1998 Aug; 89(2):493-9. PMID: 9710409.
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    181. Tjen-A-Looi SC, Pan HL, Longhurst JC. Endogenous bradykinin activates ischaemically sensitive cardiac visceral afferents through kinin B2 receptors in cats. J Physiol. 1998 Jul 15; 510 ( Pt 2):633-41. PMID: 9706010.
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    182. Song HK, Pan HL, Eisenach JC. Spinal nitric oxide mediates antinociception from intravenous morphine. Anesthesiology. 1998 Jul; 89(1):215-21. PMID: 9667311.
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    183. Li P, Pitsillides KF, Rendig SV, Pan HL, Longhurst JC. Reversal of reflex-induced myocardial ischemia by median nerve stimulation: a feline model of electroacupuncture. Circulation. 1998 Mar 31; 97(12):1186-94. PMID: 9537345.
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    184. Pan HL, Song HK, Eisenach JC. Effects of intrathecal neostigmine, bupivacaine, and their combination on sympathetic nerve activity in rats. Anesthesiology. 1998 Feb; 88(2):481-6. PMID: 9477069.
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    185. Fu LW, Pan HL, Longhurst JC. Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors. Am J Physiol. 1997 12; 273(6):H2726-37. PMID: 9435609.
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    186. Xu Z, Tong C, Pan HL, Cerda SE, Eisenach JC. Intravenous morphine increases release of nitric oxide from spinal cord by an alpha-adrenergic and cholinergic mechanism. J Neurophysiol. 1997 Oct; 78(4):2072-8. PMID: 9325374.
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    187. Pan HL, Zeisse ZB, Pitsillides KF, Longhurst JC. Spatiotemporal aspects of sympathetic C-fiber afferent activity in pressor reflex during abdominal ischemia. Am J Physiol. 1997 Apr; 272(4 Pt 2):H1928-36. PMID: 9139980.
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    188. Pan HL, Zeisse ZB, Longhurst JC. Mechanical stimulation is not responsible for activation of gastrointestinal afferents during ischemia. Am J Physiol. 1997 Jan; 272(1 Pt 2):H99-106. PMID: 9038927.
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    189. Fu LW, Pan HL, Pitsillides KF, Longhurst JC. Hypoxia does not directly stimulate ischemically sensitive abdominal visceral afferents during ischemia. Am J Physiol. 1996 Jul; 271(1 Pt 2):H261-6. PMID: 8760183.
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    190. Pan HL, Longhurst JC. Ischaemia-sensitive sympathetic afferents innervating the gastrointestinal tract function as nociceptors in cats. J Physiol. 1996 May 01; 492 ( Pt 3):841-50. PMID: 8734994.
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    191. Pan HL, Zeisse ZB, Longhurst JC. Role of summation of afferent input in cardiovascular reflexes from splanchnic nerve stimulation. Am J Physiol. 1996 Mar; 270(3 Pt 2):H849-56. PMID: 8780178.
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    192. Huang HS, Pan HL, Stahl GL, Longhurst JC. Ischemia- and reperfusion-sensitive cardiac sympathetic afferents: influence of H2O2 and hydroxyl radicals. Am J Physiol. 1995 Sep; 269(3 Pt 2):H888-901. PMID: 7573532.
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    193. Pan HL, Stahl GL, Longhurst JC. Differential effect of 5- and 15-lipoxygenase products on ischemically sensitive abdominal visceral afferents. Am J Physiol. 1995 Jul; 269(1 Pt 2):H96-105. PMID: 7631880.
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    194. Pan HL, Longhurst JC. Lack of a role of adenosine in activation of ischemically sensitive cardiac sympathetic afferents. Am J Physiol. 1995 Jul; 269(1 Pt 2):H106-13. PMID: 7631838.
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    195. Pan HL, Bonham AC, Longhurst JC. Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder. Am J Physiol. 1995 Feb; 268(2 Pt 2):H526-34. PMID: 7532372.
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    196. Amsterdam EA, Stahl GL, Pan HL, Rendig SV, Fletcher MP, Longhurst JC. Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs. Am J Physiol. 1995 Jan; 268(1 Pt 2):H448-57. PMID: 7840295.
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    197. Pan HL, Stahl GL, Rendig SV, Carretero OA, Longhurst JC. Endogenous BK stimulates ischemically sensitive abdominal visceral C fiber afferents through kinin B2 receptors. Am J Physiol. 1994 Dec; 267(6 Pt 2):H2398-406. PMID: 7810739.
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    198. Rendig SV, Pan HL, Longhurst JC. Brief mesenteric ischemia increases PGE2, but not PGI2, in intestinal lymph of cats. Am J Physiol. 1994 May; 266(5 Pt 2):R1692-6. PMID: 8203652.
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    199. Amsterdam EA, Pan HL, Rendig SV, Symons JD, Fletcher MP, Longhurst JC. Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent by inhibition of neutrophil activity without reduction of neutrophil migration. J Am Coll Cardiol. 1993 Nov 15; 22(6):1738-44. PMID: 8227848.
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    200. Pan HL, Stebbins CL, Longhurst JC. Bradykinin contributes to the exercise pressor reflex: mechanism of action. J Appl Physiol (1985). 1993 Nov; 75(5):2061-8. PMID: 8307860.
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    201. Stahl GL, Pan HL, Longhurst JC. Activation of ischemia- and reperfusion-sensitive abdominal visceral C fiber afferents. Role of hydrogen peroxide and hydroxyl radicals. Circ Res. 1993 Jun; 72(6):1266-75. PMID: 8388323.
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    202. Zhao HY, Pan HL. Experimental and clinical study of catecholamine-induced hypokalemia in acute myocardial infarction. J Tongji Med Univ. 1989; 9(3):160-4. PMID: 2600984.
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    203. Peripheral motor and sensory nerve conduction following transplantation of undifferentiated autologous adipose tissue-derived stem cells in a biodegradable U.S. food and drug administration-approved nerve conduit. Plastic and Reconstructive Surgery. 138:132-139.
    204. Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Reports. 15:1376-1383.
    205. G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition. Nature Neuroscience.
    206. Molecular basis of regulating high voltage-activated calcium channels by S-nitrosylation. Journal of Biological Chemistry. 290:30616-30623.
    207. Presynaptic N-methyl-D-aspartate (NMDA) receptor activity is increased through protein kinase C in paclitaxel-induced neuropathic pain. Journal of Biological Chemistry. 291:19364-19373.
    208. Nerve injury diminishes opioid analgesia through lysine methyltransferase-mediated transcriptional repression of μ-opioid receptors in primary sensory neurons. Journal of Biological Chemistry. 291:8475-8485.
    209. Endogenous histamine stimulates oschemicauy sensitive abdominal visceral afferents through h, receptors. FASEB Journal. 10.
    210. Mechanical stimulation is not responsible for activation of gastrointestinal afferents during ischemia. American Journal of Physiology - Heart and Circulatory Physiology. 41.
    211. Spatiotemporal aspects of sympathetic C-fiber afferent activity in pressor reflex during abdominal ischemia. American Journal of Physiology. 272.
    212. Response to glutamate receptors and presympathetic neuronal hyperactivity of the central nervous system in hypertension. Hypertension. 62.
    213. Endogenous casein kinase-1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension. Journal of Physiology. 593:4439-4452.
    214. Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced β-Endorphin Release. Molecular Neurobiology.
    215. Gabaergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. Journal of Neuroscience. 35:3312-3318.
    216. Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through HI receptors. American Journal of Physiology. 273.
    217. Mechanical stimulation is not responsible for activation of gastrointestinal afferents during ischemia. FASEB Journal. 10.
    218. Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors. American Journal of Physiology. 281.
    219. Hypoxia does not directly stimulate ischemically sensitive abdominal visceral afferents during ischemia. American Journal of Physiology - Heart and Circulatory Physiology. 40.
    220. Functional properties of silent cardiac sympathetic afferents in cats. FASEB Journal. 12.
    221. Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. Journal of Neurochemistry.
    222. Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain. Molecular Neurobiology.
    223. Src Kinases Regulate Glutamatergic Input to Hypothalamic Presympathetic Neurons and Sympathetic Outflow in Hypertension. Hypertension. 69:154-162.
    224. An update on pharmacological actions of drugs for neuropathic pain treatment. Journal of Neuropathic Pain and Symptom Palliation. 1:19-34.
    225. Erratum. Journal of Neuroscience. 21.
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