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ETHAN DMITROVSKY

TitleProfessor
InstitutionMD Anderson
DepartmentThoracic Head & Neck Medical Oncology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio LM, Kurie JM, Villalobos P, Lu W, Behrens C, Mino B, Solis LM, Silvester J, Thu KL, Cescon DW, Rodriguez-Canales J, Wistuba II, Mak TW, Liu X, Dmitrovsky E. Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy. Mol Cancer Ther. 2019 Oct; 18(10):1775-1786. PMID: 31358662.
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    2. Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E. Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition. Proc Natl Acad Sci U S A. 2018 11 13; 115(46):E10810-E10811. PMID: 30377273.
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    3. Kawakami M, Liu X, Dmitrovsky E. New Cell Cycle Inhibitors Target Aneuploidy in Cancer Therapy. Annu Rev Pharmacol Toxicol. 2019 Jan 06; 59:361-377. PMID: 30110577.
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    4. Chen L, Diao L, Yang Y, Yi X, Rodriguez BL, Li Y, Villalobos PA, Cascone T, Liu X, Tan L, Lorenzi PL, Huang A, Zhao Q, Peng D, Fradette JJ, Peng DH, Ungewiss C, Roybal J, Tong P, Oba J, Skoulidis F, Peng W, Carter BW, Gay CM, Fan Y, Class CA, Zhu J, Rodriguez-Canales J, Kawakami M, Byers LA, Woodman SE, Papadimitrakopoulou VA, Dmitrovsky E, Wang J, Ullrich SE, Wistuba II, Heymach JV, Qin FX, Gibbons DL. CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade. Cancer Discov. 2018 09; 8(9):1156-1175. PMID: 30012853.
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    5. Kawakami M, Mustachio LM, Liu X, Dmitrovsky E. Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers. Mol Cancer Ther. 2018 04; 17(4):724-731. PMID: 29559545.
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    6. Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E. Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1913-1918. PMID: 29434041.
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    7. Mustachio LM, Lu Y, Kawakami M, Roszik J, Freemantle SJ, Liu X, Dmitrovsky E. Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target. Cancer Res. 2018 02 01; 78(3):587-592. PMID: 29343520.
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    8. Yim CY, Bikorimana E, Khan E, Warzecha JM, Shin L, Rodriguez J, Dmitrovsky E, Freemantle SJ, Spinella MJ. G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer. Cell Cycle. 2017; 16(21):2146-2155. PMID: 28910567.
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    9. Sepesi B, Correa AM, Dmitrovsky E, Liu X. Reply to "Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non-Small Cell Lung Cancer: Methodological Issues". J Thorac Oncol. 2017 09; 12(9):e150-e151. PMID: 28838719.
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    10. Kawakami M, Mustachio LM, Rodriguez-Canales J, Mino B, Roszik J, Tong P, Wang J, Lee JJ, Myung JH, Heymach JV, Johnson FM, Hong S, Zheng L, Hu S, Villalobos PA, Behrens C, Wistuba I, Freemantle S, Liu X, Dmitrovsky E. Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer. J Natl Cancer Inst. 2017 06 01; 109(6). PMID: 28376145.
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    11. Sepesi B, Gold KA, Correa AM, Heymach JV, Vaporciyan AA, Roszik J, Dmitrovsky E, Liu X. The Influence of Body Mass Index on Overall Survival Following Surgical Resection of Non-Small Cell Lung Cancer. J Thorac Oncol. 2017 08; 12(8):1280-1287. PMID: 28552766.
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    12. Mustachio LM, Lu Y, Tafe LJ, Memoli V, Rodriguez-Canales J, Mino B, Villalobos PA, Wistuba I, Katayama H, Hanash SM, Roszik J, Kawakami M, Cho KJ, Hancock JF, Chinyengetere F, Hu S, Liu X, Freemantle SJ, Dmitrovsky E. Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer. Mol Cancer Res. 2017 07; 15(7):905-914. PMID: 28242811.
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    13. Mustachio LM, Kawakami M, Lu Y, Rodriguez-Canales J, Mino B, Behrens C, Wistuba I, Bota-Rabassedas N, Yu J, Lee JJ, Roszik J, Zheng L, Liu X, Freemantle SJ, Dmitrovsky E. The ISG15-specific protease USP18 regulates stability of PTEN. Oncotarget. 2017 Jan 03; 8(1):3-14. PMID: 27980214.
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    14. Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ, Dmitrovsky E. Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2. Mol Cancer Ther. 2016 11; 15(11):2758-2766. PMID: 27550941.
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    15. Yim CY, Sekula DJ, Hever-Jardine MP, Liu X, Warzecha JM, Tam J, Freemantle SJ, Dmitrovsky E, Spinella MJ. G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program. Cancer Res. 2016 Mar 01; 76(5):1204-13. PMID: 26837760.
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    16. Chinyengetere F, Sekula DJ, Lu Y, Giustini AJ, Sanglikar A, Kawakami M, Ma T, Burkett SS, Eisenberg BL, Wells WA, Hoopes PJ, Demicco EG, Lazar AJ, Torres KE, Memoli V, Freemantle SJ, Dmitrovsky E. Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas. BMC Cancer. 2015 Nov 10; 15:886. PMID: 26555296.
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    17. Uray IP, Dmitrovsky E, Brown PH. Retinoids and rexinoids in cancer prevention: from laboratory to clinic. Semin Oncol. 2016 Feb; 43(1):49-64. PMID: 26970124.
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    18. Myung JH, Roengvoraphoj M, Tam KA, Ma T, Memoli VA, Dmitrovsky E, Freemantle SJ, Hong S. Effective capture of circulating tumor cells from a transgenic mouse lung cancer model using dendrimer surfaces immobilized with anti-EGFR. Anal Chem. 2015 Oct 06; 87(19):10096-102. PMID: 26312815.
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    19. Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E. Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown. Mol Cancer Ther. 2015 Nov; 14(11):2576-85. PMID: 26304236.
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    20. Liu X, Gold KA, Dmitrovsky E. The Myb-p300 Interaction Is a Novel Molecular Pharmacologic Target. Mol Cancer Ther. 2015 Jun; 14(6):1273-5. PMID: 25995438.
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    21. Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E. CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110. Cancer Res. 2015 May 15; 75(10):2029-38. PMID: 25808870.
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    22. Gui J, Hu Z, Tsai CY, Ma T, Song Y, Morales A, Huang LH, Dmitrovsky E, Craig RW, Usherwood EJ. MCL1 enhances the survival of CD8+ memory T Cells after viral infection. J Virol. 2015 Feb; 89(4):2405-14. PMID: 25505074.
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    23. Ma T, Lopez-Aguiar AG, Li A, Lu Y, Sekula D, Nattie EE, Freemantle S, Dmitrovsky E. Mice lacking G0S2 are lean and cold-tolerant. Cancer Biol Ther. 2014 May; 15(5):643-50. PMID: 24556704.
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    24. Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biol Ther. 2014 Apr; 15(4):463-72. PMID: 24496080.
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    25. Aoyama K, Saha A, Tolar J, Riddle MJ, Veenstra RG, Taylor PA, Blomhoff R, Panoskaltsis-Mortari A, Klebanoff CA, Socié G, Munn DH, Murphy WJ, Serody JS, Fulton LM, Teshima T, Chandraratna RA, Dmitrovsky E, Guo Y, Noelle RJ, Blazar BR. Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration. Blood. 2013 Sep 19; 122(12):2125-34. PMID: 23814022.
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    26. Ma T, Galimberti F, Erkmen CP, Memoli V, Chinyengetere F, Sempere L, Beumer JH, Anyang BN, Nugent W, Johnstone D, Tsongalis GJ, Kurie JM, Li H, Direnzo J, Guo Y, Freemantle SJ, Dragnev KH, Dmitrovsky E. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013 Aug; 12(8):1545-55. PMID: 23686769.
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    27. Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ. Evidence for tankyrases as antineoplastic targets in lung cancer. BMC Cancer. 2013 Apr 28; 13:211. PMID: 23621985.
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    28. Ma T, Dong JP, Sekula DJ, Fei DL, Lamph WW, Henderson M, Lu Y, Blumen S, Freemantle SJ, Dmitrovsky E. Repression of exogenous gene expression by the retinoic acid target gene G0S2. Int J Oncol. 2013 May; 42(5):1743-53. PMID: 23546556.
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    29. Ma T, Fuld AD, Rigas JR, Hagey AE, Gordon GB, Dmitrovsky E, Dragnev KH. A phase I trial and in vitro studies combining ABT-751 with carboplatin in previously treated non-small cell lung cancer patients. Chemotherapy. 2012; 58(4):321-9. PMID: 23147218.
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    30. Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol. 2012 Nov; 41(5):1751-61. PMID: 22923130.
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    31. Guo Y, Pino-Lagos K, Ahonen CA, Bennett KA, Wang J, Napoli JL, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Turk MJ, Noelle RJ. A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells. Cancer Res. 2012 Oct 15; 72(20):5230-9. PMID: 22902413.
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    32. Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Lu Y, Galimberti F, Ma T, Feng Q, Sekula D, Freemantle SJ, Andrew AS, Memoli V, Dmitrovsky E. Evidence for the ubiquitin protease UBP43 as an antineoplastic target. Mol Cancer Ther. 2012 Sep; 11(9):1968-77. PMID: 22752428.
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    33. Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D, Singh S, Black KE, Wang Z, Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, Lam WL, Dmitrovsky E, Capobianco AJ, Robbins DJ. The hedgehog processing pathway is required for NSCLC growth and survival. Oncogene. 2013 May 02; 32(18):2335-45. PMID: 22733134.
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    34. Pino-Lagos K, Guo Y, Brown C, Alexander MP, Elgueta R, Bennett KA, De Vries V, Nowak E, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Noelle RJ. A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. J Exp Med. 2011 Aug 29; 208(9):1767-75. PMID: 21859847.
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    35. Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, Waxman S, Dmitrovsky E. Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models. Cancer Prev Res (Phila). 2011 Jun; 4(6):818-28. PMID: 21636548.
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    36. Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ. Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Res. 2011 Jul 01; 71(13):4454-63. PMID: 21565978.
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    37. Liu X, Sempere LF, Guo Y, Korc M, Kauppinen S, Freemantle SJ, Dmitrovsky E. Involvement of microRNAs in lung cancer biology and therapy. Transl Res. 2011 Apr; 157(4):200-8. PMID: 21420030.
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    38. Galimberti F, Thompson SL, Ravi S, Compton DA, Dmitrovsky E. Anaphase catastrophe is a target for cancer therapy. Clin Cancer Res. 2011 Mar 15; 17(6):1218-22. PMID: 21288923.
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    39. Freemantle SJ, Dmitrovsky E. Cyclin E transgenic mice: discovery tools for lung cancer biology, therapy, and prevention. Cancer Prev Res (Phila). 2010 Dec; 3(12):1513-8. PMID: 21149327.
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    40. Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E. Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARa and inhibits the growth of acute promyelocytic leukemia. Cancer Res. 2010 Dec 01; 70(23):9875-85. PMID: 20935222.
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    41. Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, Dmitrovsky E. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest. 2010 Apr; 120(4):1298-309. PMID: 20237410.
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    42. Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, DiRenzo J, Greninger P, Sharma SV, Settleman J, Compton DA, Dmitrovsky E. Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe. Clin Cancer Res. 2010 Jan 01; 16(1):109-20. PMID: 20028770.
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    43. Beyrouthy MJ, Garner KM, Hever MP, Freemantle SJ, Eastman A, Dmitrovsky E, Spinella MJ. High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors. Cancer Res. 2009 Dec 15; 69(24):9360-6. PMID: 19951990.
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    44. Snow GE, Kasper AC, Busch AM, Schwarz E, Ewings KE, Bee T, Spinella MJ, Dmitrovsky E, Freemantle SJ. Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. BMC Cancer. 2009 Oct 29; 9:383. PMID: 19874621.
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    45. Sempere LF, Liu X, Dmitrovsky E. Tumor-suppressive microRNAs in Lung cancer: diagnostic and therapeutic opportunities. ScientificWorldJournal. 2009 Jul 13; 9:626-8. PMID: 19618089.
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    46. Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E. Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res. 2009 Feb 15; 15(4):1177-83. PMID: 19228723.
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    47. Freemantle SJ, Guo Y, Dmitrovsky E. Retinoid chemoprevention trials: cyclin D1 in the crosshairs. Cancer Prev Res (Phila). 2009 Jan; 2(1):3-6. PMID: 19139010.
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    48. Feng Q, Sekula D, Guo Y, Liu X, Black CC, Galimberti F, Shah SJ, Sempere LF, Memoli V, Andersen JB, Hassel BA, Dragnev K, Dmitrovsky E. UBE1L causes lung cancer growth suppression by targeting cyclin D1. Mol Cancer Ther. 2008 Dec; 7(12):3780-8. PMID: 19074853.
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    49. Kitareewan S, Blumen S, Sekula D, Bissonnette RP, Lamph WW, Cui Q, Gallagher R, Dmitrovsky E. G0S2 is an all-trans-retinoic acid target gene. Int J Oncol. 2008 Aug; 33(2):397-404. PMID: 18636162.
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    50. Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB. The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis. Mol Cancer Ther. 2008 May; 7(5):1251-7. PMID: 18483313.
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    51. Shah SJ, Blumen S, Pitha-Rowe I, Kitareewan S, Freemantle SJ, Feng Q, Dmitrovsky E. UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation. Mol Cancer Ther. 2008 Apr; 7(4):905-14. PMID: 18413804.
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    52. Freemantle SJ, Liu X, Feng Q, Galimberti F, Blumen S, Sekula D, Kitareewan S, Dragnev KH, Dmitrovsky E. Cyclin degradation for cancer therapy and chemoprevention. J Cell Biochem. 2007 Nov 01; 102(4):869-77. PMID: 17868090.
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    53. Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW, Dmitrovsky E, Sporn TA, Sporn MB. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15; 67(6):2414-9. PMID: 17363558.
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    54. Dragnev KH, Petty WJ, Shah SJ, Lewis LD, Black CC, Memoli V, Nugent WC, Hermann T, Negro-Vilar A, Rigas JR, Dmitrovsky E. A proof-of-principle clinical trial of bexarotene in patients with non-small cell lung cancer. Clin Cancer Res. 2007 Mar 15; 13(6):1794-800. PMID: 17363535.
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    55. Ma Y, Fiering S, Black C, Liu X, Yuan Z, Memoli VA, Robbins DJ, Bentley HA, Tsongalis GJ, Demidenko E, Freemantle SJ, Dmitrovsky E. Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4089-94. PMID: 17360482.
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    56. Feng Q, Sekula D, Müller R, Freemantle SJ, Dmitrovsky E. Uncovering residues that regulate cyclin D1 proteasomal degradation. Oncogene. 2007 Aug 02; 26(35):5098-106. PMID: 17310991.
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    57. Freemantle SJ, Vaseva AV, Ewings KE, Bee T, Krizan KA, Kelley MR, Hattab EM, Memoli VA, Black CC, Spinella MJ, Dmitrovsky E. Repression of cyclin D1 as a target for germ cell tumors. Int J Oncol. 2007 Feb; 30(2):333-40. PMID: 17203214.
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    58. Kitareewan S, Roebuck BD, Demidenko E, Sloboda RD, Dmitrovsky E. Lysosomes and trivalent arsenic treatment in acute promyelocytic leukemia. J Natl Cancer Inst. 2007 Jan 03; 99(1):41-52. PMID: 17202112.
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    59. Dragnev KH, Feng Q, Ma Y, Shah SJ, Black C, Memoli V, Nugent W, Rigas JR, Kitareewan S, Freemantle S, Dmitrovsky E. Uncovering novel targets for cancer chemoprevention. Recent Results Cancer Res. 2007; 174:235-43. PMID: 17302201.
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    60. Ma Y, Feng Q, Pitha-Rowe I, Kitareewan S, Dmitrovsky E. Gene profiling uncovers retinoid target genes. Methods Mol Biol. 2007; 383:101-21. PMID: 18217681.
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    61. Yuan Z, Goetz JA, Singh S, Ogden SK, Petty WJ, Black CC, Memoli VA, Dmitrovsky E, Robbins DJ. Frequent requirement of hedgehog signaling in non-small cell lung carcinoma. Oncogene. 2007 Feb 15; 26(7):1046-55. PMID: 16909105.
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    62. Freemantle SJ, Dragnev KH, Dmitrovsky E. The retinoic acid paradox in cancer chemoprevention. J Natl Cancer Inst. 2006 Apr 05; 98(7):426-7. PMID: 16595769.
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    63. Dragnev KH, Petty WJ, Shah S, Biddle A, Desai NB, Memoli V, Rigas JR, Dmitrovsky E. Bexarotene and erlotinib for aerodigestive tract cancer. J Clin Oncol. 2005 Dec 01; 23(34):8757-64. PMID: 16314636.
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    64. Petty WJ, Li N, Biddle A, Bounds R, Nitkin C, Ma Y, Dragnev KH, Freemantle SJ, Dmitrovsky E. A novel retinoic acid receptor beta isoform and retinoid resistance in lung carcinogenesis. J Natl Cancer Inst. 2005 Nov 16; 97(22):1645-51. PMID: 16288117.
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    65. Giuliano CJ, Kerley-Hamilton JS, Bee T, Freemantle SJ, Manickaratnam R, Dmitrovsky E, Spinella MJ. Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15; 1731(1):48-56. PMID: 16168501.
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    66. Ma Y, Feng Q, Sekula D, Diehl JA, Freemantle SJ, Dmitrovsky E. Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15; 65(14):6476-83. PMID: 16024653.
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    67. Dragnev KH, Petty WJ, Ma Y, Rigas JR, Dmitrovsky E. Nonclassical retinoids and lung carcinogenesis. Clin Lung Cancer. 2005 Jan; 6(4):237-44. PMID: 15694016.
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    68. Petty WJ, Dragnev KH, Memoli VA, Ma Y, Desai NB, Biddle A, Davis TH, Nugent WC, Memoli N, Hamilton M, Iwata KK, Rigas JR, Dmitrovsky E. Epidermal growth factor receptor tyrosine kinase inhibition represses cyclin D1 in aerodigestive tract cancers. Clin Cancer Res. 2004 Nov 15; 10(22):7547-54. PMID: 15569985.
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    69. Pitha-Rowe I, Petty WJ, Feng Q, Koza-Taylor PH, Dimattia DA, Pinder L, Dragnev KH, Memoli N, Memoli V, Turi T, Beebe J, Kitareewan S, Dmitrovsky E. Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention. Cancer Res. 2004 Nov 01; 64(21):8109-15. PMID: 15520223.
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    70. Dmitrovsky E. Fenretinide activates a distinct apoptotic pathway. J Natl Cancer Inst. 2004 Sep 01; 96(17):1264-5. PMID: 15339958.
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    71. Dragnev KH, Pitha-Rowe I, Ma Y, Petty WJ, Sekula D, Murphy B, Rendi M, Suh N, Desai NB, Sporn MB, Freemantle SJ, Dmitrovsky E. Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. Clin Cancer Res. 2004 Apr 01; 10(7):2570-7. PMID: 15073138.
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    72. Pitha-Rowe I, Hassel BA, Dmitrovsky E. Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. J Biol Chem. 2004 Apr 30; 279(18):18178-87. PMID: 14976209.
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    73. Dmitrovsky E. Tissue microarrays for hypothesis generation. J Natl Cancer Inst. 2004 Feb 18; 96(4):248-9. PMID: 14970265.
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    74. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004; 5(3):R13. PMID: 15003116.
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    75. Freemantle SJ, Spinella MJ, Dmitrovsky E. Retinoids in cancer therapy and chemoprevention: promise meets resistance. Oncogene. 2003 Oct 20; 22(47):7305-15. PMID: 14576840.
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    76. Pitha-Rowe I, Petty WJ, Kitareewan S, Dmitrovsky E. Retinoid target genes in acute promyelocytic leukemia. Leukemia. 2003 Sep; 17(9):1723-30. PMID: 12970771.
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    77. Petty WJ, Dragnev KH, Dmitrovsky E. Cyclin D1 as a target for chemoprevention. Lung Cancer. 2003 Aug; 41 Suppl 1:S155-61. PMID: 12867074.
      View in: PubMed
    78. Ma Y, Koza-Taylor PH, DiMattia DA, Hames L, Fu H, Dragnev KH, Turi T, Beebe JS, Freemantle SJ, Dmitrovsky E. Microarray analysis uncovers retinoid targets in human bronchial epithelial cells. Oncogene. 2003 Jul 31; 22(31):4924-32. PMID: 12894236.
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    79. Dmitrovsky E. Combining cytotoxic chemotherapy with cyclooxygenase-2 inhibition. J Clin Oncol. 2003 Jul 15; 21(14):2631-2. PMID: 12860936.
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    80. Dragnev KH, Petty WJ, Dmitrovsky E. Retinoid targets in cancer therapy and chemoprevention. Cancer Biol Ther. 2003 Jul-Aug; 2(4 Suppl 1):S150-6. PMID: 14508093.
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    81. Dragnev KH, Stover D, Dmitrovsky E. Lung cancer prevention: the guidelines. Chest. 2003 Jan; 123(1 Suppl):60S-71S. PMID: 12527565.
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    82. Hirsch FR, Bunn PA, Dmitrovsky E, Field JK, Franklin WA, Greenberg RE, Hansen HH, Henschke CI, Rigas JR, Smith RA, Toennesen P, Mulshine JL. IV international conference on prevention and early detection of lung cancer, Reykjavik, Iceland, August 9-12, 2001. Lung Cancer. 2002 Sep; 37(3):325-44. PMID: 12234703.
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    83. Freemantle SJ, Portland HB, Ewings K, Dmitrovsky F, DiPetrillo K, Spinella MJ, Dmitrovsky E. Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. Gene. 2002 May 29; 291(1-2):17-27. PMID: 12095675.
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    84. Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, Golub TR, Freemantle SJ, Dmitrovsky E. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3806-11. PMID: 11891284.
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    85. Freemantle SJ, Dmitrovsky E. Clinical link between p53 and angiogenesis in lung cancer. J Clin Oncol. 2002 Feb 15; 20(4):883-4. PMID: 11844804.
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    86. Lonardo F, Dragnev KH, Freemantle SJ, Ma Y, Memoli N, Sekula D, Knauth EA, Beebe JS, Dmitrovsky E. Evidence for the epidermal growth factor receptor as a target for lung cancer prevention. Clin Cancer Res. 2002 Jan; 8(1):54-60. PMID: 11801540.
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    87. Dragnev KH, Freemantle SJ, Spinella MJ, Dmitrovsky E. Cyclin proteolysis as a retinoid cancer prevention mechanism. Ann N Y Acad Sci. 2001 Dec; 952:13-22. PMID: 11795432.
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    88. Curtin JC, Dragnev KH, Sekula D, Christie AJ, Dmitrovsky E, Spinella MJ. Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function. Oncogene. 2001 May 03; 20(20):2559-69. PMID: 11420666.
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    89. Boyle JO, Lonardo F, Chang JH, Klimstra D, Rusch V, Dmitrovsky E. Multiple high-grade bronchial dysplasia and squamous cell carcinoma: concordant and discordant mutations. Clin Cancer Res. 2001 Feb; 7(2):259-66. PMID: 11234877.
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    90. Pitts JD, Sloboda RD, Dragnev KH, Dmitrovsky E, Mycek MA. Autofluorescence characteristics of immortalized and carcinogen-transformed human bronchial epithelial cells. J Biomed Opt. 2001 Jan; 6(1):31-40. PMID: 11178578.
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    91. Spinella MJ, Dmitrovsky E. Aerosolized delivery and lung cancer prevention: pre-clinical models show promise. Clin Cancer Res. 2000 Aug; 6(8):2963-4. PMID: 10955769.
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    92. Spinella MJ, Dmitrovsky E. Aberrant retinoid signaling and breast cancer: the view from outside the nucleus. J Natl Cancer Inst. 2000 Mar 15; 92(6):438-40. PMID: 10716952.
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    93. Dragnev KH, Rigas JR, Dmitrovsky E. The retinoids and cancer prevention mechanisms. Oncologist. 2000; 5(5):361-8. PMID: 11040271.
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    94. Kitareewan S, Spinella MJ, Allopenna J, Reczek PR, Dmitrovsky E. 4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARgamma independent pathway. Oncogene. 1999 Oct 14; 18(42):5747-55. PMID: 10523855.
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    95. Hromas R, Ye H, Spinella M, Dmitrovsky E, Xu D, Costa RH. Genesis, a Winged Helix transcriptional repressor, has embryonic expression limited to the neural crest, and stimulates proliferation in vitro in a neural development model. Cell Tissue Res. 1999 Sep; 297(3):371-82. PMID: 10460485.
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    96. Albanell J, Bosl GJ, Reuter VE, Engelhardt M, Franco S, Moore MA, Dmitrovsky E. Telomerase activity in germ cell cancers and mature teratomas. J Natl Cancer Inst. 1999 Aug 04; 91(15):1321-6. PMID: 10433622.
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    97. Spinella MJ, Freemantle SJ, Sekula D, Chang JH, Christie AJ, Dmitrovsky E. Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation. J Biol Chem. 1999 Jul 30; 274(31):22013-8. PMID: 10419526.
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    98. Lonardo F, Rusch V, Langenfeld J, Dmitrovsky E, Klimstra DS. Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development. Cancer Res. 1999 May 15; 59(10):2470-6. PMID: 10344760.
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    99. Yang WL, Zeng YX, El-Deiry WS, Nason-Burchenal K, Dmitrovsky E, Chin KV. Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha. Mol Cell Biol Res Commun. 1999 May; 1(2):125-31. PMID: 10356361.
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    100. Tamayo P, Slonim D, Mesirov J, Zhu Q, Kitareewan S, Dmitrovsky E, Lander ES, Golub TR. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2907-12. PMID: 10077610.
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    101. Boyle JO, Langenfeld J, Lonardo F, Sekula D, Reczek P, Rusch V, Dawson MI, Dmitrovsky E. Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. J Natl Cancer Inst. 1999 Feb 17; 91(4):373-9. PMID: 10050872.
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    102. Yeyati PL, Shaknovich R, Boterashvili S, Li J, Ball HJ, Waxman S, Nason-Burchenal K, Dmitrovsky E, Zelent A, Licht JD. Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene. 1999 Jan 28; 18(4):925-34. PMID: 10023668.
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    103. Suh N, Wang Y, Honda T, Gribble GW, Dmitrovsky E, Hickey WF, Maue RA, Place AE, Porter DM, Spinella MJ, Williams CR, Wu G, Dannenberg AJ, Flanders KC, Letterio JJ, Mangelsdorf DJ, Nathan CF, Nguyen L, Porter WW, Ren RF, Roberts AB, Roche NS, Subbaramaiah K, Sporn MB. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res. 1999 Jan 15; 59(2):336-41. PMID: 9927043.
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    104. Nason-Burchenal K, Takle G, Pace U, Flynn S, Allopenna J, Martin P, George ST, Goldberg AR, Dmitrovsky E. Targeting the PML/RAR alpha translocation product triggers apoptosis in promyelocytic leukemia cells. Oncogene. 1998 Oct 08; 17(14):1759-68. PMID: 9778041.
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    105. Nason-Burchenal K, Allopenna J, Bègue A, Stéhelin D, Dmitrovsky E, Martin P. Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells. Blood. 1998 Sep 01; 92(5):1758-67. PMID: 9716606.
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    106. Maerz WJ, Baselga J, Reuter VE, Mellado B, Myers ML, Bosl GJ, Spinella MJ, Dmitrovsky E. FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas. Oncogene. 1998 Aug 13; 17(6):761-7. PMID: 9715278.
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    107. Spinella MJ, Kitareewan S, Mellado B, Sekula D, Khoo KS, Dmitrovsky E. Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells. Oncogene. 1998 Jul 02; 16(26):3471-80. PMID: 9692555.
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    108. Pasche B, Luo Y, Rao PH, Nimer SD, Dmitrovsky E, Caron P, Luzzatto L, Offit K, Cordon-Cardo C, Renault B, Satagopan JM, Murty VV, Massagué J. Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res. 1998 Jul 01; 58(13):2727-32. PMID: 9661882.
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    109. Albanell J, Lonardo F, Rusch V, Engelhardt M, Langenfeld J, Han W, Klimstra D, Venkatraman E, Moore MA, Dmitrovsky E. High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stage. J Natl Cancer Inst. 1997 Nov 05; 89(21):1609-15. PMID: 9362159.
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    110. Langenfeld J, Kiyokawa H, Sekula D, Boyle J, Dmitrovsky E. Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):12070-4. PMID: 9342364.
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    111. Dmitrovsky E. N-(4-hydroxyphenyl)retinamide activation of a distinct pathway signaling apoptosis. J Natl Cancer Inst. 1997 Aug 20; 89(16):1179-81. PMID: 9274907.
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    112. Nason-Burchenal K, Maerz W, Albanell J, Allopenna J, Martin P, Moore MA, Dmitrovsky E. Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization. Differentiation. 1997 Aug; 61(5):321-31. PMID: 9342843.
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    113. Rusch V, Klimstra D, Venkatraman E, Pisters PW, Langenfeld J, Dmitrovsky E. Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin Cancer Res. 1997 Apr; 3(4):515-22. PMID: 9815714.
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    114. Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E, Jetten AM. Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. J Mol Endocrinol. 1997 Apr; 18(2):167-76. PMID: 9134503.
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    115. Nason-Burchenal K, Gandini D, Botto M, Allopenna J, Seale JR, Cross NC, Goldman JM, Dmitrovsky E, Pandolfi PP. Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood. 1996 Nov 15; 88(10):3926-36. PMID: 8916959.
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    116. Langenfeld J, Lonardo F, Kiyokawa H, Passalaris T, Ahn MJ, Rusch V, Dmitrovsky E. Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation. Oncogene. 1996 Nov 07; 13(9):1983-90. PMID: 8934545.
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    117. Rusch V, Mendelsohn J, Dmitrovsky E. The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors. Cytokine Growth Factor Rev. 1996 Aug; 7(2):133-41. PMID: 8899291.
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    118. Early E, Moore MA, Kakizuka A, Nason-Burchenal K, Martin P, Evans RM, Dmitrovsky E. Transgenic expression of PML/RARalpha impairs myelopoiesis. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7900-4. PMID: 8755574.
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    119. Moasser MM, Khoo KS, Maerz WJ, Zelenetz A, Dmitrovsky E. Derivation and characterization of retinoid-resistant human embryonal carcinoma cells. Differentiation. 1996 Jul; 60(4):251-7. PMID: 8765055.
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    120. Hoffman AD, Engelstein D, Bogenrieder T, Papandreou CN, Steckelman E, Dave A, Motzer RJ, Dmitrovsky E, Albino AP, Nanus DM. Expression of retinoic acid receptor beta in human renal cell carcinomas correlates with sensitivity to the antiproliferative effects of 13-cis-retinoic acid. Clin Cancer Res. 1996 Jun; 2(6):1077-82. PMID: 9816270.
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    121. Baldassarre G, Bianco C, Tortora G, Ruggiero A, Moasser M, Dmitrovsky E, Bianco AR, Ciardiello F. Transfection with a CRIPTO anti-sense plasmid suppresses endogenous CRIPTO expression and inhibits transformation in a human embryonal carcinoma cell line. Int J Cancer. 1996 May 16; 66(4):538-43. PMID: 8635871.
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    122. Albanell J, Han W, Mellado B, Gunawardane R, Scher HI, Dmitrovsky E, Moore MA. Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines. Cancer Res. 1996 Apr 01; 56(7):1503-8. PMID: 8603393.
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    123. Ahn MJ, Langenfeld J, Moasser MM, Rusch V, Dmitrovsky E. Growth suppression of transformed human bronchial epithelial cells by all-trans-retinoic acid occurs through specific retinoid receptors. Oncogene. 1995 Dec 07; 11(11):2357-64. PMID: 8570187.
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    124. Rusch V, Klimstra D, Venkatraman E, Oliver J, Martini N, Gralla R, Kris M, Dmitrovsky E. Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res. 1995 Nov 01; 55(21):5038-42. PMID: 7585548.
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    125. Moasser MM, Motzer RJ, Khoo KS, Lyn P, Murphy BA, Bosl GJ, Dmitrovsky E. all-trans retinoic acid for treating germ cell tumors. In vitro activity and results of a phase II trial. Cancer. 1995 Aug 15; 76(4):680-6. PMID: 8625166.
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    126. Early E, Dmitrovsky E. Acute promyelocytic leukemia: retinoic acid response and resistance. J Investig Med. 1995 Aug; 43(4):337-44. PMID: 7552583.
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    127. Ahn MJ, Nason-Burchenal K, Moasser MM, Dmitrovsky E. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. 1995 Jun 15; 10(12):2307-14. PMID: 7784078.
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    128. Moasser MM, Reuter VE, Dmitrovsky E. Overexpression of the retinoic acid receptor gamma directly induces terminal differentiation of human embryonal carcinoma cells. Oncogene. 1995 Apr 20; 10(8):1537-43. PMID: 7731708.
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    129. Rusch V, Klimstra D, Linkov I, Dmitrovsky E. Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development. Cancer Res. 1995 Mar 15; 55(6):1365-72. PMID: 7882337.
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    130. Rusch VW, Dmitrovsky E. Molecular biologic features of non-small cell lung cancer. Clinical implications. Chest Surg Clin N Am. 1995 Feb; 5(1):39-55. PMID: 7743147.
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    131. Pace U, Bockman JM, MacKay BJ, Miller WH, Dmitrovsky E, Goldberg AR. A ribozyme which discriminates in vitro between PML/RAR alpha, the t(15;17)-associated fusion RNA of acute promyelocytic leukemia, and PML and RAR alpha, the transcripts from the nonrearranged alleles. Cancer Res. 1994 Dec 15; 54(24):6365-9. PMID: 7987829.
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    132. Kurie JM, Allopenna J, Dmitrovsky E. Retinoic acid stimulates protein kinase A-associated G proteins during human teratocarcinoma differentiation. Biochim Biophys Acta. 1994 May 26; 1222(1):88-94. PMID: 8186270.
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    133. Moasser MM, DeBlasio A, Dmitrovsky E. Response and resistance to retinoic acid are mediated through the retinoic acid nuclear receptor gamma in human teratocarcinomas. Oncogene. 1994 Mar; 9(3):833-40. PMID: 8108126.
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    134. Frankel SR, Eardley A, Heller G, Berman E, Miller WH, Dmitrovsky E, Warrell RP. All-trans retinoic acid for acute promyelocytic leukemia. Results of the New York Study. Ann Intern Med. 1994 Feb 15; 120(4):278-86. PMID: 8291820.
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    135. Miller WH, Maerz WJ, Kurie J, Moy D, Baselga J, Lucas DA, Grippo JF, Masui H, Dmitrovsky E. All-trans-retinoic acid and hexamethylene bisacetamide (HMBA) regulate TGF-alpha and Hst-1/kFGF expression in differentiation sensitive but not in resistant human teratocarcinomas. Differentiation. 1994 Jan; 55(2):145-52. PMID: 8143931.
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    136. Motzer RJ, Dmitrovsky E, Miller WH, Tong WP, Bajorin DF, Scher HI, Bost GJ. Suramin for germ cell tumors. In vitro growth inhibition and results of a phase II trial. Cancer. 1993 Dec 01; 72(11):3313-7. PMID: 8242558.
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    137. Baselga J, Maerz WJ, Moy D, Miller WH, Castro L, Reuter VE, Yao TJ, Masui H, Dmitrovsky E. Over-expression of transforming growth factor alpha antagonizes the anti-tumorigenic but not the differentiation actions of retinoic acid in a human teratocarcinoma cell. Oncogene. 1993 Dec; 8(12):3257-63. PMID: 8247529.
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    138. Kurie JM, Younes A, Miller WH, Burchert M, Chiu CF, Kolesnick R, Dmitrovsky E. Retinoic acid stimulates the protein kinase C pathway before activation of its beta-nuclear receptor during human teratocarcinoma differentiation. Biochim Biophys Acta. 1993 Nov 07; 1179(2):203-7. PMID: 8218362.
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    139. Xiao YH, Miller WH, Warrell RP, Dmitrovsky E, Zelenetz AD. Pulsed-field gel electrophoresis analysis of retinoic acid receptor-alpha and promyelocytic leukemia rearrangements. Detection of the t(15;17) translocation in the diagnosis of acute promyelocytic leukemia. Am J Pathol. 1993 Nov; 143(5):1301-11. PMID: 8238249.
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    140. Miller WH, Levine K, DeBlasio A, Frankel SR, Dmitrovsky E, Warrell RP. Detection of minimal residual disease in acute promyelocytic leukemia by a reverse transcription polymerase chain reaction assay for the PML/RAR-alpha fusion mRNA. Blood. 1993 Sep 15; 82(6):1689-94. PMID: 8400225.
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    141. Kurie JM, Buck J, Eppinger TM, Moy D, Dmitrovsky E. 9-cis and all-trans retinoic acid induce a similar phenotype in human teratocarcinoma cells. Differentiation. 1993 Sep; 54(2):123-9. PMID: 8243889.
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    142. Kurie JM, Brown P, Salk E, Scheinberg D, Birrer M, Deutsch P, Dmitrovsky E. Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation. Differentiation. 1993 Sep; 54(2):115-22. PMID: 8243888.
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    143. Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, McIntosh J, Kurie J, Dmitrovsky E. Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res. 1993 May 15; 53(10 Suppl):2379-85. PMID: 7683573.
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    144. Maslak P, Miller WH, Heller G, Scheinberg DA, Dmitrovsky E, Warrell RP. CD2 expression and PML/RAR-alpha transcripts in acute promyelocytic leukemia. Blood. 1993 Mar 15; 81(6):1666. PMID: 8095829.
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    145. Miller WH, Dmitrovsky E. Retinoic acid and its rearranged receptor in the treatment of acute promyelocytic leukemia. Important Adv Oncol. 1993; 81-90. PMID: 8389321.
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    146. Rusch VW, Reuter VE, Kris MG, Kurie J, Miller WH, Nanus DM, Albino AP, Dmitrovsky E. Ras oncogene point mutation: an infrequent event in bronchioloalveolar cancer. J Thorac Cardiovasc Surg. 1992 Nov; 104(5):1465-9. PMID: 1331621.
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    147. Frankel SR, Miller WH, Dmitrovsky E. Retinoic acid and its rearranged receptor in the etiology and treatment of acute promyelocytic leukemia. Oncology (Williston Park). 1992 Aug; 6(8):74-78, 83; discussion 84, 87-8. PMID: 1323988.
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    148. Miller WH, Kakizuka A, Frankel SR, Warrell RP, DeBlasio A, Levine K, Evans RM, Dmitrovsky E. Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2694-8. PMID: 1372989.
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    149. Kurie JM, Bosl GJ, Dmitrovsky E. The genetic and biologic aspects of treatment response and resistance in male germ cell cancer. Semin Oncol. 1992 Apr; 19(2):197-205. PMID: 1313192.
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    150. Dmitrovsky E, Bosl GJ. Active cancer therapy combining 13-cis-retinoic acid with interferon-alpha. J Natl Cancer Inst. 1992 Feb 19; 84(4):218-9. PMID: 1734081.
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    151. Muindi J, Frankel SR, Miller WH, Jakubowski A, Scheinberg DA, Young CW, Dmitrovsky E, Warrell RP. Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia. Blood. 1992 Jan 15; 79(2):299-303. PMID: 1309668.
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    152. Ilson DH, Bosl GJ, Motzer R, Dmitrovsky E, Chaganti RS. Genetic analysis of germ cell tumors: current progress and future prospects. Hematol Oncol Clin North Am. 1991 Dec; 5(6):1271-83. PMID: 1663944.
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    153. Kakizuka A, Miller WH, Umesono K, Warrell RP, Frankel SR, Murty VV, Dmitrovsky E, Evans RM. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23; 66(4):663-74. PMID: 1652368.
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    154. Warrell RP, Frankel SR, Miller WH, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A, et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med. 1991 May 16; 324(20):1385-93. PMID: 1850498.
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    155. Motzer RJ, Rodriguez E, Reuter VE, Samaniego F, Dmitrovsky E, Bajorin DF, Pfister DG, Parsa NZ, Chaganti RS, Bosl GJ. Genetic analysis as an aid in diagnosis for patients with midline carcinomas of uncertain histologies. J Natl Cancer Inst. 1991 Mar 06; 83(5):341-6. PMID: 1847433.
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    156. Miller WH, Dmitrovsky E. Oncogenes and clinical oncology. Curr Opin Oncol. 1991 Feb; 3(1):65-9. PMID: 1646034.
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    157. Miller WH, Dmitrovsky E. Growth factors in human germ cell cancer. Recent Results Cancer Res. 1991; 123:183-9. PMID: 1660620.
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    158. Dmitrovsky E, Rodriguez E, Samaniego F, Reuter VE, Miller WH, Geller NL, Bosl GJ, Chaganti RS. Analysis of chromosome 12 abnormalities in male germ cell cancers. Recent Results Cancer Res. 1991; 123:119-23. PMID: 1660617.
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    159. Miller WH, Warrell RP, Frankel SR, Jakubowski A, Gabrilove JL, Muindi J, Dmitrovsky E. Novel retinoic acid receptor-alpha transcripts in acute promyelocytic leukemia responsive to all-trans-retinoic acid. J Natl Cancer Inst. 1990 Dec 19; 82(24):1932-3. PMID: 2174466.
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    160. Motzer RJ, Cooper K, Geller NL, Bajorin DF, Dmitrovsky E, Herr H, Morse M, Fair W, Sogani P, Russo P, et al. The role of ifosfamide plus cisplatin-based chemotherapy as salvage therapy for patients with refractory germ cell tumors. Cancer. 1990 Dec 15; 66(12):2476-81. PMID: 2174300.
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    161. Murty VV, Dmitrovsky E, Bosl GJ, Chaganti RS. Nonrandom chromosome abnormalities in testicular and ovarian germ cell tumor cell lines. Cancer Genet Cytogenet. 1990 Nov 01; 50(1):67-73. PMID: 2253191.
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    162. Dmitrovsky E, Seifter EJ, Gazdar AF, Tsai CM, Edison M, Brantley P, Veach SR, Batist G, Ihde DC, Mulshine JL. A phase II trial of carboplatin (CBDCA) in small-cell and non-small-cell lung cancer with correlation to in vitro analysis of cytotoxicity. Am J Clin Oncol. 1990 Aug; 13(4):285-9. PMID: 2165737.
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    163. Miller WH, Moy D, Li A, Grippo JF, Dmitrovsky E. Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line. Oncogene. 1990 Apr; 5(4):511-7. PMID: 2158037.
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    164. Dmitrovsky E, Murty VV, Moy D, Miller WH, Nanus D, Albino AP, Samaniego F, Bosl G, Chaganti RS. Isochromosome 12p in non-seminoma cell lines: karyologic amplification of c-ki-ras2 without point-mutational activation. Oncogene. 1990 Apr; 5(4):543-8. PMID: 2183156.
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    165. Samaniego F, Rodriguez E, Houldsworth J, Murty VV, Ladanyi M, Lele KP, Chen QG, Dmitrovsky E, Geller NL, Reuter V, et al. Cytogenetic and molecular analysis of human male germ cell tumors: chromosome 12 abnormalities and gene amplification. Genes Chromosomes Cancer. 1990 Mar; 1(4):289-300. PMID: 2177638.
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    166. Dmitrovsky E, Moy D, Miller WH, Li A, Masui H. Retinoic acid causes a decline in TGF-alpha expression, cloning efficiency, and tumorigenicity in a human embryonal cancer cell line. Oncogene Res. 1990; 5(3):233-9. PMID: 2320376.
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    167. Dmitrovsky E, Bosl GJ, Chaganti RS. Clinical and genetic features of human germ cell cancer. Cancer Surv. 1990; 9(2):369-86. PMID: 1964627.
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    168. Dmitrovsky E, Markman M, Marks PA. Clinical use of differentiating agents in cancer therapy. Cancer Chemother Biol Response Modif. 1990; 11:303-20. PMID: 2223397.
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    169. Bosl GJ, Dmitrovsky E, Reuter VE, Samaniego F, Rodriguez E, Geller NL, Chaganti RS. Isochromosome of the short arm of chromosome 12: clinically useful markers for male germ cell tumors. J Natl Cancer Inst. 1989 Dec 20; 81(24):1874-8. PMID: 2556586.
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    170. Segal S, Dmitrovsky E, Paez de la Cadena M. The effect of a transfected c-myc proto-oncogene on cellular differentiation. Mol Immunol. 1988 Nov; 25(11):1129-32. PMID: 3221882.
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    171. Kuehl WM, Bender TP, Stafford J, McClinton D, Segal S, Dmitrovsky E. Expression and function of the c-myb oncogene during hematopoietic differentiation. Curr Top Microbiol Immunol. 1988; 141:318-23. PMID: 3063446.
      View in: PubMed
    172. Dmitrovsky E, Matthews MJ, Bunn PA, Schechter GP, Makuch RW, Winkler CF, Eddy J, Sausville EA, Ihde DC. Cytologic transformation in cutaneous T cell lymphoma: a clinicopathologic entity associated with poor prognosis. J Clin Oncol. 1987 Feb; 5(2):208-15. PMID: 3492594.
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    173. Seibel NL, Funa K, Dmitrovsky E, Foss F, Hollis GF, Kirsch IR. Application of RNA-RNA tissue in situ hybridization in an analysis of a patient with leukemia. Hum Pathol. 1987 Jan; 18(1):3-8. PMID: 3817798.
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    174. Dmitrovsky E, Kuehl WM, Hollis GF, Kirsch IR, Bender TP, Segal S. Expression of a transfected human c-myc oncogene inhibits differentiation of a mouse erythroleukaemia cell line. Nature. 1986 Aug 21-27; 322(6081):748-50. PMID: 3528861.
      View in: PubMed
    175. Dmitrovsky E, Martin SE, Krudy AG, Chu EW, Jaffe ES, Longo DL, Young RC. Lymph node aspiration in the management of Hodgkin's disease. J Clin Oncol. 1986 Mar; 4(3):306-10. PMID: 3950673.
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    176. Chang H, Dmitrovsky E, Hieter PA, Mitchell K, Leder P, Turoczi L, Kirsch IR, Hollis GF. Identification of three new Ig lambda-like genes in man. J Exp Med. 1986 Feb 01; 163(2):425-35. PMID: 3003227.
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    177. Dmitrovsky E, Kuehl WM, Hollis GF, Kirsch IR, Bender TP, Segal S. A transfected c-myc oncogene inhibits mouse erythroleukemic differentiation. Curr Top Microbiol Immunol. 1986; 132:327-30. PMID: 3466771.
      View in: PubMed
    178. Dmitrovsky E, Boskey AL. Calcium-acidic phospholipid-phosphate complexes in human atherosclerotic aortas. Calcif Tissue Int. 1985 Mar; 37(2):121-5. PMID: 2988716.
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    179. The myb-p300 interaction is a novel molecular pharmacologic target. Molecular Cancer Therapeutics. 14:1273-1275.
    180. Specific CP110 phosphorylation sites mediate anaphase catastrophe after CDK2 inhibition. Molecular Cancer Therapeutics. 14:2576-2585.
    181. Effective Capture of Circulating Tumor Cells from a Transgenic Mouse Lung Cancer Model Using Dendrimer Surfaces Immobilized with Anti-EGFR. Analytical Chemistry. 87:10096-10102.
    182. Fluorescence spectroscopy and imaging for noninvasive diagnostics. 70-80.
    183. The ISG15-specific protease USP18 regulates stability of PTEN. Oncotarget. 8:3-14.
    184. Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas. BMC Cancer. 15.
    185. Retinoids and rexinoids in cancer prevention. Seminars in Oncology. 43:49-64.
    186. A UV-visible-NIR fluorescence lifetime imaging microscope for laser-based biological sensing with picosecond resolution. Applied Physics B: Lasers and Optics. 76:483-496.
    187. GOS2 suppresses oncogenic transformation by repressing a MYC-regulated transcriptional program. Cancer Research. 76:1204-1213.
    188. The characterization of the tidemark in human articular cartilage. Metabolic Bone Disease and Related Research. 1:115-118.
    189. Dinaciclib induces anaphase catastrophe in lung cancer cells via inhibition of cyclin-dependent kinases 1 and 2. Molecular Cancer Therapeutics. 15:2758-2766.
    190. Probing endogenous fluorophores in cellular cancer models using temporally and spectrally resolved laser induced fluorescence. 587-588.
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