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DAVID TWEARDY

TitleProfessor
InstitutionMD Anderson
DepartmentInfectious Diseases, Infection Control, and Employee Health
Address1515 Holcombe Blvd.
Houston TX 77030
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    K11HL001763     (TWEARDY, DAVID JOHN)Apr 1, 1986 - Mar 31, 1991
    NIH/NHLBI
    SUPPRESSION OF HEMOPOIESIS BY A NOVEL LYMPHOKINE
    Role: Principal Investigator

    T32AI007333     (MELLORS, JOHN W)Sep 1, 1988 - Aug 31, 2011
    NIH/NIAID
    Training in AIDS Molecular Epi/Microbiology &STDs
    Role: Co-Principal Investigator

    R01CA072261     (TWEARDY, DAVID JOHN)May 1, 1996 - Jun 30, 2008
    NIH/NCI
    Mechanisms of G-CSF Receptor Mediated Differentiation
    Role: Principal Investigator

    R01CA086430     (TWEARDY, DAVID JOHN)Sep 1, 1999 - Jun 30, 2005
    NIH/NCI
    STAT3 INTERACTIONS IN CELL GROWTH AND DIFFERENTIATION
    Role: Principal Investigator

    T32AI055413     (ATMAR, ROBERT L.)Aug 1, 2003 - May 31, 2019
    NIH/NIAID
    Research Training in Infection and Immunity
    Role: Co-Principal Investigator

    R01HL076169     (TWEARDY, DAVID JOHN)Feb 1, 2004 - Jan 31, 2009
    NIH/NHLBI
    REVERSAL OF HYPOVOLEMIC CIRCULATORY COLLAPSE BY IL-6
    Role: Principal Investigator

    R21CA149783     (TWEARDY, DAVID JOHN)Jul 1, 2010 - Jun 30, 2012
    NIH/NCI
    Stat3 Probes that Target Breast Cancer Stem Cells
    Role: Principal Investigator

    R41CA153658     (TWEARDY, DAVID JOHN)Sep 26, 2012 - Aug 31, 2014
    NIH/NCI
    Chemical probes that target Stat3 to treat cancer
    Role: Principal Investigator

    R21CA191556     (TWEARDY, DAVID JOHN)Dec 1, 2014 - Nov 30, 2016
    NIH/NCI
    Targeting Stat1 and Stat3 to Reverse Radioresistance in Head and Neck Cancer
    Role: Principal Investigator

    R42DK104494     (TWEARDY, DAVID JOHN)Apr 1, 2016 - Mar 31, 2019
    NIH/NIDDK
    Oral Small Molecule STAT3 Inhibitor to Treat Cachexia in Chronic Kidney Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kettner NM, Vijayaraghavan S, Durak MG, Bui T, Kohansal M, Ha MJ, Liu B, Rao X, Wang J, Yi M, Carey JP, Chen X, Eckols TK, Raghavendra AS, Ibrahim NK, Karuturi MS, Watowich SS, Sahin A, Tweardy DJ, Hunt KK, Tripathy D, Keyomarsi K. Combined inhibition of STAT3 and DNA repair in palbociclib-resistant ER-positive breast cancer. Clin Cancer Res. 2019 Mar 13. PMID: 30867218.
      View in: PubMed
    2. Pedroza M, To S, Assassi S, Wu M, Tweardy D, Agarwal SK. Role of STAT3 in skin fibrosis and transforming growth factor beta signalling. Rheumatology (Oxford). 2018 10 01; 57(10):1838-1850. PMID: 29029263.
      View in: PubMed
    3. Kasembeli MM, Bharadwaj U, Robinson P, Tweardy DJ. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int J Mol Sci. 2018 Aug 05; 19(8). PMID: 30081609.
      View in: PubMed
    4. Singh M, Vianden C, Cantwell MJ, Dai Z, Xiao Z, Sharma M, Khong H, Jaiswal AR, Faak F, Hailemichael Y, Janssen LME, Bharadwaj U, Curran MA, Diab A, Bassett RL, Tweardy DJ, Hwu P, Overwijk WW. Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain. Nat Commun. 2017 11 13; 8(1):1447. PMID: 29129918.
      View in: PubMed
    5. Hassan MM, Botrus G, Abdel-Wahab R, Wolff RA, Li D, Tweardy D, Phan AT, Hawk E, Javle M, Lee JS, Torres HA, Rashid A, Lenzi R, Hassabo HM, Abaza Y, Shalaby AS, Lacin S, Morris J, Patt YZ, Amos CI, Khaderi SA, Goss JA, Jalal PK, Kaseb AO. Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2017 Nov; 15(11):1791-1799. PMID: 28579181.
      View in: PubMed
    6. Jung KH, Yoo W, Stevenson HL, Deshpande D, Shen H, Gagea M, Yoo SY, Wang J, Eckols TK, Bharadwaj U, Tweardy DJ, Beretta L. Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice. Clin Cancer Res. 2017 Sep 15; 23(18):5537-5546. PMID: 28533225.
      View in: PubMed
    7. Bocchini CE, Nahmod K, Katsonis P, Kim S, Kasembeli MM, Freeman A, Lichtarge O, Makedonas G, Tweardy DJ. Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome. Blood. 2016 12 29; 128(26):3061-3072. PMID: 27799162.
      View in: PubMed
    8. Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophys J. 2016 06 07; 110(11):2377-2385. PMID: 27276256.
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    9. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 03; 7(18):26307-30. PMID: 27027445.
      View in: PubMed
    10. Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Rep. 2016 Apr 26; 15(4):843-856. PMID: 27149849.
      View in: PubMed
    11. Mahale P, Sturgis EM, Tweardy DJ, Ariza-Heredia EJ, Torres HA. Association Between Hepatitis C Virus and Head and Neck Cancers. J Natl Cancer Inst. 2016 08; 108(8). PMID: 27075854.
      View in: PubMed
    12. Hox V, O'Connell MP, Lyons JJ, Sackstein P, Dimaggio T, Jones N, Nelson C, Boehm M, Holland SM, Freeman AF, Tweardy DJ, Olivera A, Metcalfe DD, Milner JD. Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol. 2016 07; 138(1):187-99. PMID: 26948077.
      View in: PubMed
    13. Robinson P, Kasembeli M, Bharadwaj U, Engineer N, Eckols KT, Tweardy DJ. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. Biomed Res Int. 2016; 2016:1959270. PMID: 26981525; PMCID: PMC4766315.
    14. Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. J Biol Chem. 2016 Feb 26; 291(9):4732-41. PMID: 26706127; PMCID: PMC4813495 [Available on 02/26/17].
    15. Yuan H, Houck KL, Tian Y, Bharadwaj U, Hull K, Zhou Z, Zhu M, Zhou M, Wu X, Tweardy DJ, Romo D, Fu X, Zhang Y, Zhang J, Dong JF. Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species. PLoS One. 2015; 10(12):e0143964. PMID: 26645674.
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    16. Roh SH, Kasembeli M, Bakthavatsalam D, Chiu W, Tweardy DJ. Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci. 2015 Nov 06; 16(11):26706-20. PMID: 26561808; PMCID: PMC4661834.
    17. Zhang HF, Chen Y, Wu C, Wu ZY, Tweardy DJ, Alshareef A, Liao LD, Xue YJ, Wu JY, Chen B, Xu XE, Gopal K, Gupta N, Li EM, Xu LY, Lai R. The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3ß in Esophageal Squamous Cell Carcinoma. Clin Cancer Res. 2016 Feb 01; 22(3):691-703. PMID: 26405196.
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    18. Lewis KM, Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Fridley C, Siller R, Tweardy DJ. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer. 2015 Nov; 90(2):182-90. PMID: 26410177.
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    19. Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT. Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13085-9. PMID: 26480340.
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    20. Pedroza M, Le TT, Lewis K, Karmouty-Quintana H, To S, George AT, Blackburn MR, Tweardy DJ, Agarwal SK. STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation. FASEB J. 2016 Jan; 30(1):129-40. PMID: 26324850; PMCID: PMC4684532 [Available on 01/01/17].
    21. Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Corrigendum to "Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis". Biomed Res Int. 2015; 2015:869648. PMID: 26078968; PMCID: PMC4452501.
    22. Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24; 290(17):11177-87. PMID: 25787076.
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    23. DiNardo AR, Schmidt D, Mitchell A, Kaufman Y, Tweardy DJ. First Description of Oral Cryptococcus neoformans Causing Osteomyelitis of the Mandible, Manubrium and Third Rib with Associated Soft Tissue Abscesses in an Immunocompetent Host. Clin Microbiol Case Rep. 2015; 1(3). PMID: 27227123.
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    24. Bocchini CE, Kasembeli MM, Roh SH, Tweardy DJ. Contribution of chaperones to STAT pathway signaling. JAKSTAT. 2014; 3(3):e970459. PMID: 26413421; PMCID: PMC4580081.
    25. Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT. STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells. 2014 Oct; 32(10):2571-82. PMID: 24891218.
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    26. Bharadwaj U, Kasembeli MM, Eckols TK, Kolosov M, Lang P, Christensen K, Edwards DP, Tweardy DJ. Monoclonal Antibodies Specific for STAT3ß Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer. Cancers (Basel). 2014 Sep 29; 6(4):2012-34. PMID: 25268166; PMCID: PMC4276954.
    27. Khumbatta M, Firozgary B, Tweardy DJ, Weinstock J, Firozgary G, Bhatena Z, Bulsara T, Siller R, Robinson P. Somatostatin negatively regulates parasite burden and granulomatous responses in cysticercosis. Biomed Res Int. 2014; 2014:247182. PMID: 25530957; PMCID: PMC4121154.
    28. Bakthavatsalam D, Soung RH, Tweardy DJ, Chiu W, Dixon RA, Woodside DG. Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor. FEBS Lett. 2014 Jun 13; 588(13):2133-40. PMID: 24846140; PMCID: PMC4100626.
    29. Chatzimpaloglou A, Kolosov M, Eckols TK, Tweardy DJ, Sarli V. Synthetic and biological studies of phaeosphaerides. J Org Chem. 2014 May 02; 79(9):4043-54. PMID: 24735379.
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    30. Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W, Tweardy DJ. Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol. 2014 Apr; 12(4):e1001844. PMID: 24756126; PMCID: PMC3995649.
    31. Haricharan S, Dong J, Hein S, Reddy JP, Du Z, Toneff M, Holloway K, Hilsenbeck SG, Huang S, Atkinson R, Woodward W, Jindal S, Borges VF, Gutierrez C, Zhang H, Schedin PJ, Osborne CK, Tweardy DJ, Li Y. Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. Elife. 2013 Dec 31; 2:e00996. PMID: 24381245; PMCID: PMC3874103.
    32. Thacker S, Moran A, Lionakis M, Mastrangelo MA, Halder T, del Pilar Huby M, Wu Y, Tweardy DJ. Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock. J Infect. 2014 Mar; 68(3):231-41. PMID: 24291043.
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    33. Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE. Stat3 activation links a C/EBPd to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013 Sep 03; 18(3):368-79. PMID: 24011072.
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    34. Hillion J, Belton AM, Shah SN, Turkson J, Jing N, Tweardy DJ, di Cello F, Huso DL, Resar LM. Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leuk Lymphoma. 2014 May; 55(5):1194-7. PMID: 23829279.
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    35. Elsarraj HS, Hong Y, Valdez K, Carletti M, Salah SM, Raimo M, Taverna D, Prochasson P, Bharadwaj U, Tweardy DJ, Christenson LK, Behbod F. A novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance. J Cell Sci. 2013 Jun 01; 126(Pt 11):2446-58. PMID: 23572509; PMCID: PMC3679487.
    36. Fan Y, Kong R, Tweardy DJ, Wong ST. WITHDRAWN: Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study. J Struct Biol. 2013 Feb 18. PMID: 23428430.
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    37. Thacker SA, Robinson P, Abel A, Tweardy DJ. Modulation of the unfolded protein response during hepatocyte and cardiomyocyte apoptosis in trauma/hemorrhagic shock. Sci Rep. 2013; 3:1187. PMID: 23378918; PMCID: PMC3561621.
    38. Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S. FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood. 2013 Feb 14; 121(7):1083-93. PMID: 23243289; PMCID: PMC3575754.
    39. Anne Morrison C, Moran A, Patel S, Vidaurre Mdel P, Carrick MM, Tweardy DJ. Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock. J Infect. 2013 Jan; 66(1):87-94. PMID: 23063873; PMCID: PMC3518635.
    40. Liao KS, Lehman SM, Tweardy DJ, Donlan RM, Trautner BW. Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters. J Appl Microbiol. 2012 Dec; 113(6):1530-9. PMID: 22985454; PMCID: PMC3501575.
    41. Dave B, Landis MD, Tweardy DJ, Chang JC, Dobrolecki LE, Wu MF, Zhang X, Westbrook TF, Hilsenbeck SG, Liu D, Lewis MT. Selective small molecule Stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS One. 2012; 7(8):e30207. PMID: 22879872; PMCID: PMC3412855.
    42. Robinson P, Garza A, Weinstock J, Serpa JA, Goodman JC, Eckols KT, Firozgary B, Tweardy DJ. Substance P causes seizures in neurocysticercosis. PLoS Pathog. 2012 Feb; 8(2):e1002489. PMID: 22346746; PMCID: PMC3276565.
    43. Trautner BW, Lopez AI, Kumar A, Siddiq DM, Liao KS, Li Y, Tweardy DJ, Cai C. Nanoscale surface modification favors benign biofilm formation and impedes adherence by pathogens. Nanomedicine. 2012 Apr; 8(3):261-70. PMID: 22197726; PMCID: PMC3311755.
    44. Roig IL, Musher DM, Tweardy DJ. Severe pulmonary involvement in a case attributed to domestically acquired Seoul hantavirus in the United States. Clin Infect Dis. 2012 Jan 01; 54(1):91-4. PMID: 22042876.
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    45. Weatherhead JE, Tweardy DJ. Lethal human neutropenic entercolitis caused by Clostridium chauvoei in the United States: tip of the iceberg? J Infect. 2012 Feb; 64(2):225-7. PMID: 21945880.
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    46. Moran A, Thacker SA, Arikan AA, Mastrangelo MA, Wu Y, Yu B, Tweardy DJ. IL-6-mediated activation of Stat3a prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One. 2011; 6(6):e21449. PMID: 21738667; PMCID: PMC3127578.
    47. Kelly JD, Teeter LD, Graviss EA, Tweardy DJ. Intracranial tuberculomas in adults: a report of twelve consecutive patients in Houston, Texas. Scand J Infect Dis. 2011 Oct; 43(10):785-91. PMID: 21696248.
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    48. Tweardy D, Chang JC. Stat5: from breast development to cancer prognosis, prediction, and progression. J Clin Oncol. 2011 Jun 20; 29(18):2443-4. PMID: 21576641.
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    49. Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26; 117(21):5701-9. PMID: 21447830; PMCID: PMC3110027.
    50. Garza A, Tweardy DJ, Weinstock J, Viswanathan B, Robinson P. Substance P signaling contributes to granuloma formation in Taenia crassiceps infection, a murine model of cysticercosis. J Biomed Biotechnol. 2010; 2010:597086. PMID: 20150970; PMCID: PMC2817809.
    51. Qiu JJ, Lu X, Zeisig BB, Ma Z, Cai X, Chen S, Gronemeyer H, Tweardy DJ, So CW, Dong S. Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}. Blood. 2010 Jan 21; 115(3):643-52. PMID: 19965660.
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    52. Tweardy DJ, Belmont JW. "Personalizing" academic medicine: opportunities and challenges in implementing genomic profiling. Transl Res. 2009 Dec; 154(6):288-94. PMID: 19931194; PMCID: PMC2830892.
    53. Corrales-Medina VF, Serpa J, Rueda AM, Giordano TP, Bozkurt B, Madjid M, Tweardy D, Musher DM. Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore). 2009 May; 88(3):154-9. PMID: 19440118.
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    54. Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ. Substance P is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med. 2009; 2(1):76-86. PMID: 19436834; PMCID: PMC2680056.
    55. Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS One. 2009; 4(3):e4783. PMID: 19274102.
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    56. Moran A, Tsimelzon AI, Mastrangelo MA, Wu Y, Yu B, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3. Clin Transl Sci. 2009 Feb; 2(1):41-9. PMID: 20443866.
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    57. Kasembeli MM, Xu X, Tweardy DJ. SH2 domain binding to phosphopeptide ligands: potential for drug targeting. Front Biosci (Landmark Ed). 2009 Jan 01; 14:1010-22. PMID: 19273114.
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    58. Robinson P, Martin P, Garza A, D'Souza M, Mastrangelo MA, Tweardy D. Substance P receptor antagonism for treatment of cryptosporidiosis in immunosuppressed mice. J Parasitol. 2008 Oct; 94(5):1150-4. PMID: 18576802.
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    59. Weerasinghe P, Li Y, Guan Y, Zhang R, Tweardy DJ, Jing N. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. Prostate. 2008 Sep 15; 68(13):1430-42. PMID: 18615483; PMCID: PMC2574665.
    60. Trautner BW, Cevallos ME, Li H, Riosa S, Hull RA, Hull SI, Tweardy DJ, Darouiche RO. Increased expression of type-1 fimbriae by nonpathogenic Escherichia coli 83972 results in an increased capacity for catheter adherence and bacterial interference. J Infect Dis. 2008 Sep 15; 198(6):899-906. PMID: 18643750; PMCID: PMC2965608.
    61. Moran A, Akcan Arikan A, Mastrangelo MA, Wu Y, Yu B, Poli V, Tweardy DJ. Prevention of trauma and hemorrhagic shock-mediated liver apoptosis by activation of stat3alpha. Int J Clin Exp Med. 2008; 1(3):213-47. PMID: 18997875.
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    62. Garza A, Lackner A, Aye P, D'Souza M, Martin P, Borda J, Tweardy DJ, Weinstock J, Griffiths J, Robinson P. Substance P receptor antagonist reverses intestinal pathophysiological alterations occurring in a novel ex-vivo model of Cryptosporidium parvum infection of intestinal tissues derived from SIV-infected macaques. J Med Primatol. 2008 Jun; 37(3):109-15. PMID: 18547256.
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    63. Alten JA, Moran A, Tsimelzon AI, Mastrangelo MA, Hilsenbeck SG, Poli V, Tweardy DJ. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS One. 2008 Feb 13; 3(2):e1605. PMID: 18270592; PMCID: PMC2225503.
    64. Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem. 2007 Nov 30; 282(48):34958-67. PMID: 17855361.
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    65. Qiu J, Huang Y, Chen G, Chen Z, Tweardy DJ, Dong S. Aberrant chromatin remodeling by retinoic acid receptor alpha fusion proteins assessed at the single-cell level. Mol Biol Cell. 2007 Oct; 18(10):3941-51. PMID: 17671166.
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    66. Redell MS, Tsimelzon A, Hilsenbeck SG, Tweardy DJ. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol. 2007 Oct; 82(4):975-85. PMID: 17634277.
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    67. Hernandez J, Lackner A, Aye P, Mukherjee K, Tweardy DJ, Mastrangelo MA, Weinstock J, Griffiths J, D'Souza M, Dixit S, Robinson P. Substance P is responsible for physiological alterations such as increased chloride ion secretion and glucose malabsorption in cryptosporidiosis. Infect Immun. 2007 Mar; 75(3):1137-43. PMID: 17158891; PMCID: PMC1828596.
    68. Tweardy DJ, Khoshnevis MR, Yu B, Mastrangelo MA, Hardison EG, López JA. Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Shock. 2006 Oct; 26(4):386-90. PMID: 16980886.
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    69. Goetzl L, Zighelboim I, Badell M, Rivers J, Mastrangèlo MA, Tweardy D, Suresh MS. Maternal corticosteroids to prevent intrauterine exposure to hyperthermia and inflammation: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2006 Oct; 195(4):1031-7. PMID: 16875647.
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    70. Shelburne SA, Greenberg SB, Aslam S, Tweardy DJ. Successful ceftriaxone therapy of endocarditis due to penicillin non-susceptible viridans streptococci. J Infect. 2007 Feb; 54(2):e99-101. PMID: 16824611.
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    71. Arikan AA, Yu B, Mastrangelo MA, Tweardy DJ. Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock. Crit Care Med. 2006 Mar; 34(3):771-7. PMID: 16521270.
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    72. Shao H, Xu X, Jing N, Tweardy DJ. Unique structural determinants for Stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744. J Immunol. 2006 Mar 01; 176(5):2933-41. PMID: 16493051.
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    73. Qiu J, Wong J, Tweardy DJ, Dong S. Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor beta. Oncogene. 2006 Jun 29; 25(28):3982-93. PMID: 16474840.
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    74. Jing N, Zhu Q, Yuan P, Li Y, Mao L, Tweardy DJ. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol Cancer Ther. 2006 Feb; 5(2):279-86. PMID: 16505101.
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    75. Tweardy DJ, Jing N. Enhancing or eliminating signals for cell survival to treat disease. Trans Am Clin Climatol Assoc. 2006; 117:33-51; discussion 51-2. PMID: 18528463; PMCID: PMC1500908.
    76. Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol. 2006; 3(3):261-7. PMID: 24980527.
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    77. Yakub I, Lillibridge KM, Moran A, Gonzalez OY, Belmont J, Gibbs RA, Tweardy DJ. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. J Infect Dis. 2005 Nov 15; 192(10):1741-8. PMID: 16235172.
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    78. Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs. 2005 Jul; 16(6):601-7. PMID: 15930886.
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    79. Wehner S, Schwarz NT, Hundsdoerfer R, Hierholzer C, Tweardy DJ, Billiar TR, Bauer AJ, Kalff JC. Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery. 2005 Apr; 137(4):436-46. PMID: 15800492.
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    80. Vallejo JG, Nemoto S, Ishiyama M, Yu B, Knuefermann P, Diwan A, Baker JS, Defreitas G, Tweardy DJ, Mann DL. Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1272-7. PMID: 15706046.
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    81. Redell MS, Tweardy DJ. Targeting transcription factors for cancer therapy. Curr Pharm Des. 2005; 11(22):2873-87. PMID: 16101443.
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    82. Jing N, Sha W, Li Y, Xiong W, Tweardy DJ. Rational drug design of G-quartet DNA as anti-cancer agents. Curr Pharm Des. 2005; 11(22):2841-54. PMID: 16101441.
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    83. Brundage SI, Zautke NA, Holcomb JB, Spain DA, Lam JC, Mastrangelo MA, Macaitis JM, Tweardy DJ. Interleukin-6 infusion blunts proinflammatory cytokine production without causing systematic toxicity in a swine model of uncontrolled hemorrhagic shock. J Trauma. 2004 Nov; 57(5):970-7; discussion 977-8. PMID: 15580019.
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    84. Jing N, Li Y, Xiong W, Sha W, Jing L, Tweardy DJ. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res. 2004 Sep 15; 64(18):6603-9. PMID: 15374974.
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    85. Ono M, Yu B, Hardison EG, Mastrangelo MA, Tweardy DJ. Increased susceptibility to liver injury after hemorrhagic shock in rats chronically fed ethanol: role of nuclear factor-kappa B, interleukin-6, and granulocyte colony-stimulating factor. Shock. 2004 Jun; 21(6):519-25. PMID: 15167680.
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    86. Dong S, Stenoien DL, Qiu J, Mancini MA, Tweardy DJ. Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor alpha. Mol Cell Biol. 2004 May; 24(10):4465-75. PMID: 15121864; PMCID: PMC400470.
    87. Shao H, Xu X, Mastrangelo MA, Jing N, Cook RG, Legge GB, Tweardy DJ. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. J Biol Chem. 2004 Apr 30; 279(18):18967-73. PMID: 14966128.
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    88. Hierholzer C, Kalff JC, Billiar TR, Bauer AJ, Tweardy DJ, Harbrecht BG. Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G225-33. PMID: 14715517.
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    89. Dong S, Chen SJ, Tweardy DJ. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leuk Lymphoma. 2003 Dec; 44(12):2023-9. PMID: 14959844.
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    90. Jing N, Li Y, Xu X, Sha W, Li P, Feng L, Tweardy DJ. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol. 2003 Nov; 22(11):685-96. PMID: 14659041.
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    91. Shao H, Cheng HY, Cook RG, Tweardy DJ. Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res. 2003 Jul 15; 63(14):3923-30. PMID: 12873986.
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    92. Brundage SI, Schreiber MA, Holcomb JB, Zautke N, Mastrangelo MA, Xq X, Macaitis J, Tweardy DJ. Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine. J Surg Res. 2003 Jul; 113(1):74-80. PMID: 12943813.
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    93. Schreiber MA, Holcomb JB, Hedner U, Brundage SI, Macaitis JM, Aoki N, Meng ZH, Tweardy DJ, Hoots K. The effect of recombinant factor VIIa on noncoagulopathic pigs with grade V liver injuries. J Am Coll Surg. 2003 May; 196(5):691-7. PMID: 12742197.
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    94. Hierholzer C, Billiar TR, Tweardy DJ, Harbrecht B. Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavenging. Arch Orthop Trauma Surg. 2003 Apr; 123(2-3):55-9. PMID: 12721681.
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    95. Kalff JC, Türler A, Schwarz NT, Schraut WH, Lee KK, Tweardy DJ, Billiar TR, Simmons RL, Bauer AJ. Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg. 2003 Mar; 237(3):301-15. PMID: 12616113; PMCID: PMC1514322.
    96. Dong S, Qiu J, Stenoien DL, Brinkley WR, Mancini MA, Tweardy DJ. Essential role for the dimerization domain of NuMA-RARalpha in its oncogenic activities and localization to NuMA sites within the nucleus. Oncogene. 2003 Feb 13; 22(6):858-68. PMID: 12584566.
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    97. Dong S, Tweardy DJ. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood. 2002 Apr 15; 99(8):2637-46. PMID: 11929748.
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    98. Hierholzer C, Billiar TR, Tweardy DJ. Requirements for NF-kappaB activation in hemorrhagic shock. Arch Orthop Trauma Surg. 2002 Feb; 122(1):44-7. PMID: 11995880.
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    99. Hierholzer C, Menezes JM, Ungeheuer A, Billiar TR, Tweardy DJ, Harbrecht BG. A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock. 2002 Feb; 17(2):98-103. PMID: 11837796.
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    100. Shao H, Quintero AJ, Tweardy DJ. Identification and characterization of cis elements in the STAT3 gene regulating STAT3 alpha and STAT3 beta messenger RNA splicing. Blood. 2001 Dec 15; 98(13):3853-6. PMID: 11739197.
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    101. Meng ZH, Dyer K, Billiar TR, Tweardy DJ. Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol. 2001 Feb; 280(2):C343-51. PMID: 11208530.
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    102. Hierholzer C, Kalff JC, Chakraborty A, Watkins SC, Billiar TR, Bauer AJ, Tweardy DJ. Impaired gut contractility following hemorrhagic shock is accompaied by IL-6 and G-CSF production and neutrophil infiltration. Dig Dis Sci. 2001 Feb; 46(2):230-41. PMID: 11281168.
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    103. Hierholzer C, Harbrecht BG, Billiar TR, Tweardy DJ. Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock. Arch Orthop Trauma Surg. 2001; 121(4):219-22. PMID: 11317684.
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    104. Chakraborty A, Dyer KF, Tweardy DJ. Delineation and mapping of Stat5 isoforms activated by granulocyte colony-stimulating factor in myeloid cells. Blood Cells Mol Dis. 2000 Aug; 26(4):320-30. PMID: 11042034.
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    105. Meng ZH, Dyer K, Billiar TR, Tweardy DJ. Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock. Shock. 2000 Jul; 14(1):41-8. PMID: 10909892.
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    106. White SM, Alarcon MH, Tweardy DJ. Inhibition of granulocyte colony-stimulating factor-mediated myeloid maturation by low level expression of the differentiation-defective class IV granulocyte colony-stimulating factor receptor isoform. Blood. 2000 Jun 01; 95(11):3335-40. PMID: 10828013.
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    107. Villavicencio RT, Liu S, Kibbe MR, Williams DL, Ganster RW, Dyer KF, Tweardy DJ, Billiar TR, Pitt BR. Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression. Shock. 2000 Jun; 13(6):441-5. PMID: 10847630.
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    108. Lou W, Ni Z, Dyer K, Tweardy DJ, Gao AC. Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway . Prostate. 2000 Feb 15; 42(3):239-42. PMID: 10639195.
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    109. Hierholzer C, Kalff JC, Audolfsson G, Billiar TR, Tweardy DJ, Bauer AJ. Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury. Transplantation. 1999 Nov 15; 68(9):1244-54. PMID: 10573059.
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    110. Menezes J, Hierholzer C, Watkins SC, Lyons V, Peitzman AB, Billiar TR, Tweardy DJ, Harbrecht BG. A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock. Am J Physiol. 1999 07; 277(1):G144-51. PMID: 10409161.
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    111. Kirkwood JM, Farkas DL, Chakraborty A, Dyer KF, Tweardy DJ, Abernethy JL, Edington HD, Donnelly SS, Becker D. Systemic interferon-alpha (IFN-alpha) treatment leads to Stat3 inactivation in melanoma precursor lesions. Mol Med. 1999 Jan; 5(1):11-20. PMID: 10072444.
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    112. Hierholzer C, Kalff JC, Bednarski B, Memarzadeh F, Kim YM, Billiar TR, Tweardy DJ. Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock. Arch Orthop Trauma Surg. 1999; 119(5-6):332-6. PMID: 10447634.
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    113. Chakraborty A, Dyer KF, Cascio M, Mietzner TA, Tweardy DJ. Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor. Blood. 1999 Jan 01; 93(1):15-24. PMID: 9864141.
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    114. Chakraborty A, Tweardy DJ. Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils. J Leukoc Biol. 1998 Nov; 64(5):675-80. PMID: 9823774.
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    115. Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR. Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res. 1998 Nov; 4(11):2913-21. PMID: 9829760.
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    116. Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, Tweardy DJ. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest. 1998 Oct 01; 102(7):1385-92. PMID: 9769331; PMCID: PMC508986.
    117. Hierholzer C, Kalff JC, Omert L, Tsukada K, Loeffert JE, Watkins SC, Billiar TR, Tweardy DJ. Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. Am J Physiol. 1998 09; 275(3):L611-21. PMID: 9728057.
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    118. Hierholzer C, Kalff JC, Billiar TR, Bauer A, Tweardy DJ. Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile. Transplant Proc. 1998 Sep; 30(6):2647. PMID: 9745531.
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    119. Chakraborty A, Tweardy DJ. Stat3 and G-CSF-induced myeloid differentiation. Leuk Lymphoma. 1998 Aug; 30(5-6):433-42. PMID: 9711905.
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    120. Grandis JR, Zeng Q, Drenning SD, Tweardy DJ. Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head and neck squamous cell carcinoma cell line. Int J Oncol. 1998 Aug; 13(2):375-8. PMID: 9664135.
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    121. He Y, Zeng Q, Drenning SD, Melhem MF, Tweardy DJ, Huang L, Grandis JR. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst. 1998 Jul 15; 90(14):1080-7. PMID: 9672256.
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    122. Gregory SH, Wing EJ, Danowski KL, van Rooijen N, Dyer KF, Tweardy DJ. IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections. J Immunol. 1998 Jun 15; 160(12):6056-61. PMID: 9637522.
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    123. Rubin Grandis J, Melhem MF, Gooding WE, Day R, Holst VA, Wagener MM, Drenning SD, Tweardy DJ. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst. 1998 Jun 03; 90(11):824-32. PMID: 9625170.
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    124. White SM, Ball ED, Ehmann WC, Rao AS, Tweardy DJ. Increased expression of the differentiation-defective granulocyte colony-stimulating factor receptor mRNA isoform in acute myelogenous leukemia. Leukemia. 1998 Jun; 12(6):899-906. PMID: 9639418.
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    125. Grandis JR, Chakraborty A, Zeng Q, Melhem MF, Tweardy DJ. Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem. 1998 Apr 01; 69(1):55-62. PMID: 9513046.
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    126. Hierholzer C, Harbrecht B, Menezes JM, Kane J, MacMicking J, Nathan CF, Peitzman AB, Billiar TR, Tweardy DJ. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med. 1998 Mar 16; 187(6):917-28. PMID: 9500794; PMCID: PMC2212185.
    127. Hierholzer C, Kelly E, Lyons V, Roedling E, Davies P, Billiar TR, Tweardy DJ. G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia. J Leukoc Biol. 1998 Feb; 63(2):169-74. PMID: 9468275.
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    128. Rubin Grandis J, Tweardy DJ, Melhem MF. Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma. Clin Cancer Res. 1998 Jan; 4(1):13-20. PMID: 9516947.
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    129. Hierholzer C, Kalff JC, Billiar TR, Tweardy DJ. Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock. Arch Orthop Trauma Surg. 1998; 117(6-7):372-5. PMID: 9709854.
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    130. Hierholzer C, Kelly E, Tsukada K, Loeffert E, Watkins S, Billiar TR, Tweardy DJ. Hemorrhagic shock induces G-CSF expression in bronchial epithelium. Am J Physiol. 1997 Nov; 273(5 Pt 1):L1058-64. PMID: 9374735.
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    131. Rubin Grandis J, Chakraborty A, Melhem MF, Zeng Q, Tweardy DJ. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene. 1997 Jul 24; 15(4):409-16. PMID: 9242377.
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    132. Perumal NB, Kenniston TW, Tweardy DJ, Dyer KF, Hoffman R, Peschon J, Appasamy PM. TCR-gamma genes are rearranged but not transcribed in IL-7R alpha-deficient mice. J Immunol. 1997 Jun 15; 158(12):5744-50. PMID: 9190924.
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    133. Hierholzer C, Kelly E, Billiar TR, Tweardy DJ. Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase. Arch Orthop Trauma Surg. 1997; 116(3):173-6. PMID: 9061173.
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    134. Chakraborty A, White SM, Schaefer TS, Ball ED, Dyer KF, Tweardy DJ. Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood. 1996 Oct 01; 88(7):2442-9. PMID: 8839834.
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    135. Rubin Grandis J, Melhem MF, Barnes EL, Tweardy DJ. Quantitative immunohistochemical analysis of transforming growth factor-alpha and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer. 1996 Sep 15; 78(6):1284-92. PMID: 8826952.
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    136. Morel BF, Burke MA, Kalagnanam J, McCarthy SA, Tweardy DJ, Morel PA. Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model. Bull Math Biol. 1996 May; 58(3):569-94. PMID: 8688839.
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    137. Rubin Grandis J, Zeng Q, Tweardy DJ. Retinoic acid normalizes the increased gene transcription rate of TGF-alpha and EGFR in head and neck cancer cell lines. Nat Med. 1996 Feb; 2(2):237-40. PMID: 8574972.
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    138. Tweardy DJ, Wright TM, Ziegler SF, Baumann H, Chakraborty A, White SM, Dyer KF, Rubin KA. Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. Blood. 1995 Dec 15; 86(12):4409-16. PMID: 8541528.
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    139. Prezioso JA, Wang J, Kim M, Duty L, Tweardy DJ, Gorelik E. Augmentation of TNF cytotoxicity by protein kinase C inhibitors: role of arachidonic acid and manganese superoxide dismutase. Cytokine. 1995 Aug; 7(6):517-25. PMID: 8580367.
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    140. Lai CF, Morella KK, Wang Y, Kumaki S, Gearing D, Ziegler SF, Tweardy DJ, Campos SP, Baumann H. Function of hematopoietin receptor subunits in hepatic cells and fibroblasts. Ann N Y Acad Sci. 1995 Jul 21; 762:189-205; discussion 206. PMID: 7545363.
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    141. Tkatch LS, Rubin KA, Ziegler SF, Tweardy DJ. Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid. J Leukoc Biol. 1995 Jun; 57(6):964-71. PMID: 7540644.
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    142. Morel PA, Chang HJ, Wilson JW, Conte C, Falkner D, Tweardy DJ, Medsger TA. HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies. Hum Immunol. 1995 Jan; 42(1):35-42. PMID: 7751158.
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    143. Su GL, Freeswick PD, Geller DA, Wang Q, Shapiro RA, Wan YH, Billiar TR, Tweardy DJ, Simmons RL, Wang SC. Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression. J Immunol. 1994 Jul 15; 153(2):743-52. PMID: 8021509.
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    144. Morel PA, Chang HJ, Wilson JW, Conte C, Saidman SL, Bray JD, Tweardy DJ, Medsger TA. Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele. Hum Immunol. 1994 Jun; 40(2):101-10. PMID: 7928439.
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    145. Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4683-7. PMID: 8197119; PMCID: PMC43852.
    146. Stewart-Akers AM, Cairns JS, Tweardy DJ, McCarthy SA. Granulocyte-macrophage colony-stimulating factor augmentation of T-cell receptor-dependent and T-cell receptor-independent thymocyte proliferation. Blood. 1994 Feb 01; 83(3):713-23. PMID: 8298134.
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    147. Steinman RA, Tweardy DJ. Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood. 1994 Jan 01; 83(1):119-27. PMID: 8274731.
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    148. Tkatch LS, Tweardy DJ. Human granulocyte colony-stimulating factor (G-CSF), the premier granulopoietin: biology, clinical utility, and receptor structure and function. Lymphokine Cytokine Res. 1993 Dec; 12(6):477-88. PMID: 7510132.
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    149. Wang SC, Morel PA, Wang Q, Jordan ML, Simmons RL, Tweardy DJ. A dual mechanism of immunosuppression by FK-506. Differential suppression of IL-4 and IL-10 levels in T helper 2 cells. Transplantation. 1993 Oct; 56(4):978-85. PMID: 7692640.
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    150. Kim M, Rao MV, Tweardy DJ, Prakash M, Galili U, Gorelik E. Lectin-induced apoptosis of tumour cells. Glycobiology. 1993 Oct; 3(5):447-53. PMID: 8286857.
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    151. Geller DA, Nguyen D, Shapiro RA, Nussler A, Di Silvio M, Freeswick P, Wang SC, Tweardy DJ, Simmons RL, Billiar TR. Cytokine induction of interferon regulatory factor-1 in hepatocytes. Surgery. 1993 Aug; 114(2):235-42. PMID: 7688150.
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    152. Stewart-Akers AM, Cairns JS, Tweardy DJ, McCarthy SA. Effect of granulocyte-macrophage colony-stimulating factor on lymphokine-activated killer cell induction. Blood. 1993 May 15; 81(10):2671-8. PMID: 8490177.
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    153. Grandis JR, Tweardy DJ. TGF-alpha and EGFR in head and neck cancer. J Cell Biochem Suppl. 1993; 17F:188-91. PMID: 8412192.
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    154. Geller DA, Kispert PH, Su GL, Wang SC, Di Silvio M, Tweardy DJ, Billiar TR, Simmons RL. Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response. Arch Surg. 1993 Jan; 128(1):22-7; discussion 27-8. PMID: 8418776.
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    155. Grandis JR, Tweardy DJ. The role of peptide growth factors in head and neck carcinoma. Otolaryngol Clin North Am. 1992 Oct; 25(5):1105-15. PMID: 1408194.
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    156. Wang SC, Jordan ML, Tweardy DJ, Wright J, Hoffman RA, Simmons RL. FK-506 inhibits proliferation and IL-4 messenger RNA production by a T-helper 2 cell line. J Surg Res. 1992 Aug; 53(2):199-202. PMID: 1383612.
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    157. Tweardy DJ, Morel PA, Mott PL, Glazer EW, Zeh HJ, Sakurai M. Modulation of myeloid proliferation and differentiation by monoclonal antibodies directed against a protein that interacts with the interleukin-3 receptor. Blood. 1992 Jul 15; 80(2):359-66. PMID: 1378315.
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    158. Gregory SH, Wing EJ, Tweardy DJ, Shadduck RK, Lin HS. Primary listerial infections are exacerbated in mice administered neutralizing antibody to macrophage colony-stimulating factor. J Immunol. 1992 Jul 01; 149(1):188-93. PMID: 1535085.
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    159. Tweardy DJ, Anderson K, Cannizzaro LA, Steinman RA, Croce CM, Huebner K. Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. Blood. 1992 Mar 01; 79(5):1148-54. PMID: 1371413.
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    160. Morel PA, Walker JA, Livingstone AM, Tweardy DJ, Cairns JS. Proto-oncogene transcription after activation of Th-1 and Th-2 cells. Ann N Y Acad Sci. 1991 Dec 30; 636:386-9. PMID: 1838913.
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    161. Wang SC, Zeevi A, Jordan ML, Simmons RL, Tweardy DJ. FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line. Transplant Proc. 1991 Dec; 23(6):2920-2. PMID: 1721312.
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    162. Tweardy DJ, Morel PA, Herberman RB, Sakurai M. Inhibition of growth of mouse leukemic cell lines in vitro and in vivo by a monoclonal antibody that recognizes an interleukin 3 receptor-associated protein. Cancer Res. 1991 Aug 15; 51(16):4355-9. PMID: 1868459.
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    163. Tweardy DJ, Glazer EW, Mott PL, Anderson K. Modulation by tumor necrosis factor-alpha of human astroglial cell production of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). J Neuroimmunol. 1991 Jun; 32(3):269-78. PMID: 1709645.
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    164. Morel PA, Schreurs J, Townsend K, Gross M, Chiller JM, Tweardy DJ. Identification of a novel protein capable of interacting with the IL-3 receptor. J Immunol. 1991 Apr 01; 146(7):2295-304. PMID: 2005398.
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    165. Ford HR, Hoffman RA, Tweardy DJ, Kispert P, Wang S, Simmons RL. Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development. Transplantation. 1991 Mar; 51(3):656-61. PMID: 2006523.
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    166. Wang SC, Tweardy DJ, Ford HR, Hoffman RA, Simmons RL. Cytokine products of T-helper 2 (Th2) cells are present in rejecting sponge matrix allografts. Transplant Proc. 1991 Feb; 23(1 Pt 1):809-10. PMID: 1824998.
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    167. Tweardy DJ, Sasaki M, Cardamone JJ, McCoy JP, Bonidie MJ, Signorella AP. Production of laminin B2 chain protein and messenger RNA by a murine neutrophil precursor cell line, 32Dc13. Blood. 1990 Oct 01; 76(7):1398-404. PMID: 1698480.
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    168. Tweardy DJ, Mott PL, Glazer EW. Monokine modulation of human astroglial cell production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. I. Effects of IL-1 alpha and IL-beta. J Immunol. 1990 Mar 15; 144(6):2233-41. PMID: 1690240.
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    169. Sriwanthana B, Hemachudha T, Griffin DE, Manutsathit S, Tweardy D, Phanuphak P. Lymphocyte subsets in human encephalitic and paralytic rabies. Acta Neurol Scand. 1989 Oct; 80(4):287-9. PMID: 2816284.
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    170. Rovera G, Tweardy DJ, Santoli D, Altmann S, Valtieri M, Lange B. Proliferation and differentiation of human myelogenous leukemia and preleukemia cells in culture: identification of stimulatory and suppressor growth factors. Haematologica. 1987 Nov-Dec; 72(6 Suppl):104-10. PMID: 3127285.
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    171. Tweardy DJ, Cannizzaro LA, Palumbo AP, Shane S, Huebner K, Vantuinen P, Ledbetter DH, Finan JB, Nowell PC, Rovera G. Molecular cloning and characterization of a cDNA for human granulocyte colony-stimulating factor (G-CSF) from a glioblastoma multiforme cell line and localization of the G-CSF gene to chromosome band 17q21. Oncogene Res. 1987 Aug; 1(3):209-20. PMID: 2453015.
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    172. Rich EA, Tweardy DJ, Fujiwara H, Ellner JJ. Spectrum of immunoregulatory functions and properties of human alveolar macrophages. Am Rev Respir Dis. 1987 Aug; 136(2):258-65. PMID: 2956914.
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    173. Valtieri M, Tweardy DJ, Caracciolo D, Johnson K, Mavilio F, Altmann S, Santoli D, Rovera G. Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol. 1987 Jun 01; 138(11):3829-35. PMID: 2438328.
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    174. Valtieri M, Santoli D, Caracciolo D, Kreider BL, Altmann SW, Tweardy DJ, Gemperlein I, Mavilio F, Lange B, Rovera G. Establishment and characterization of an undifferentiated human T leukemia cell line which requires granulocyte-macrophage colony stimulatory factor for growth. J Immunol. 1987 Jun 01; 138(11):4042-50. PMID: 2953797.
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    175. Tweardy DJ, Osman GS, el Kholy A, Ellner JJ. Failure of immunosuppressive mechanisms in human Schistosoma mansoni infection with hepatosplenomegaly. J Clin Microbiol. 1987 May; 25(5):768-73. PMID: 2953755; PMCID: PMC266086.
    176. Salata RA, Lederman MM, Shlaes DM, Jacobs MR, Eckstein E, Tweardy D, Toossi Z, Chmielewski R, Marino J, King CH, et al. Diagnosis of nosocomial pneumonia in intubated, intensive care unit patients. Am Rev Respir Dis. 1987 Feb; 135(2):426-32. PMID: 3101559.
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    177. Tweardy DJ, Caracciolo D, Valtieri M, Rovera G. Tumor-derived growth factors that support proliferation and differentiation of normal and leukemic hemopoietic cells. Ann N Y Acad Sci. 1987; 511:30-8. PMID: 2830826.
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    178. Tweardy DJ, Fujiwara H, Scillian JJ, Ellner JJ. Concurrent enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma. Cell Immunol. 1986 Jun; 100(1):34-46. PMID: 2943410.
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    179. Santoli D, Tweardy DJ, Ferrero D, Kreider BL, Rovera G. A suppressor lymphokine produced by human T leukemia cell lines. Partial characterization and spectrum of activity against normal and malignant hemopoietic cells. J Exp Med. 1986 Jan 01; 163(1):18-40. PMID: 2416868; PMCID: PMC2188018.
    180. Tweardy DJ. Relapsing toxic shock syndrome in the puerperium. JAMA. 1985 Jun 14; 253(22):3249-50. PMID: 3999307.
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    181. Croce CM, Isobe M, Palumbo A, Puck J, Ming J, Tweardy D, Erikson J, Davis M, Rovera G. Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms. Science. 1985 Mar 01; 227(4690):1044-7. PMID: 3919442.
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    182. Ellner JJ, Tweardy DJ, Osman GS, Wilson C, El Kholy A, Rocklin RE. Increased blastogenic responses to worm antigen and loss of adherent suppressor cell activity after treatment for human infection with Schistosoma mansoni. J Infect Dis. 1985 Feb; 151(2):320-4. PMID: 3155782.
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    183. Shlaes DM, Lederman MM, Chmielewski R, Tweardy D, Krause G, Saffai C. Sputum elastin fibers and the diagnosis of necrotizing pneumonia. Chest. 1984 Jun; 85(6):763-6. PMID: 6723386.
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    184. Tweardy DJ, Fujiwara H, Ellner JJ. Enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma. Trans Assoc Am Physicians. 1984; 97:353-64. PMID: 6442952.
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    185. Tweardy DJ, Schacter BZ, Ellner JJ. Association of altered dynamics of monocyte surface expression of human leukocyte antigen DR with immunosuppression in tuberculosis. J Infect Dis. 1984 Jan; 149(1):31-7. PMID: 6607294.
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    186. Tweardy DJ, Jacobs MR, Speck WT. Susceptibility of penicillin-resistant pneumococci to eighteen antimicrobials: implications for treatment of meningitis. J Antimicrob Chemother. 1983 Aug; 12(2):133-9. PMID: 6555189.
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    187. Shlaes DM, Lederman M, Chmielewski R, Tweardy D, Wolinsky E. Elastin fibers in the sputum of patients with necrotizing pneumonia. Chest. 1983 Jun; 83(6):885-9. PMID: 6851690.
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    188. Tweardy DJ, Osman GS, El Kholy A, Ellner JJ. Abnormalities of immunosuppression in patients with hepatosplenic schistosomiasis mansoni. Trans Assoc Am Physicians. 1983; 96:392-400. PMID: 6238469.
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    189. Erratum. BioMed Research International. 2015.
    190. Identification and characterization of CIS elements within the STAT3 gene regulating STAT3α and STAT3β mRNA ratios. Blood. 96.
    191. STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation. FASEB Journal. 30:129-140.
    192. Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer. Oncogenesis. 5:e181.
    193. Association between hepatitis C virus and head and neck cancers. Journal of the National Cancer Institute. 108.
    194. Granulocyte colony-stimulating factor. 525-546.
    195. Targeting transcription factors in cancer. Drug Discovery Today: Technologies. 3:261-267.
    196. Erratum. PLoS One. 11.
    197. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Reports. 15:843-856.
    198. Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer. Lung Cancer.
    199. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 7:26307-26330.
    200. Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angewandte Chemie - International Edition. 54:13085-13089.
    201. STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model. Allergy: European Journal of Allergy and Clinical Immunology.
    202. Chaperonin TRiC/CCT modulates the folding and activity of leukemogenic fusion oncoprotein AML1-ETO. Journal of Biological Chemistry. 291:4732-4741.
    203. The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma. Clinical Cancer Research. 22:691-703.
    204. Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophysical Journal. 110:2377-2385.
    205. Hemorrhagic shock induces G-CSF expression in bronchial epithelium. American Journal of Physiology. 273.
    206. Intrinsic molecular characteristics of inhibiting STAT3 activation and dimerization through targeting the phosphotyrosine binding site within the SH2 domain-A molecular dynamics study. Journal of Structural Biology.
    207. Rapid detection of T helper 2 cells by message amplification phenotyping. Surgical Forum. 41:397-399.
    208. Monoclonal antibodies specific for Stat3β reveal its contribution to constitutive Stat3 phosphorylation in breast cancer. Cancers. 6:2012-2034.
    209. Contribution of the type II chaperonin, TRiC/CCT, to oncogenesis. International Journal of Molecular Sciences. 16:26706-26720.
    210. Substance P Receptor Signaling Mediates Doxorubicin-Induced Cardiomyocyte Apoptosis and Triple-Negative Breast Cancer Chemoresistance. BioMed Research International. 2016.
    211. Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. Journal of Allergy and Clinical Immunology.
    212. Reply to Seligman [2]. Journal of Infectious Diseases. 193:1188.
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