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DAVID PIWNICA-WORMS

TitleProfessor
InstitutionMD Anderson
DepartmentCancer Systems Imaging
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gammon ST, Pisaneschi F, Bandi ML, Smith MG, Sun Y, Rao Y, Muller F, Wong F, De Groot J, Ackroyd J, Mawlawi O, Davies MA, Gopal YNV, Di Francesco ME, Marszalek JR, Dewhirst M, Piwnica-Worms D. Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo. Cells. 2019 Nov 21; 8(12). PMID: 31766580.
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    2. Vashisht Gopal YN, Gammon S, Prasad R, Knighton B, Pisaneschi F, Roszik J, Feng N, Johnson S, Pramanik S, Sudderth J, Sui D, Hudgens C, Fischer GM, Deng W, Reuben A, Peng W, Wang J, McQuade JL, Tetzlaff MT, Di Francesco ME, Marszalek J, Piwnica-Worms D, DeBerardinis RJ, Davies MA. A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma. Clin Cancer Res. 2019 Nov 01; 25(21):6429-6442. PMID: 31439581.
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    3. Radaram B, Pisaneschi F, Rao Y, Yang P, Piwnica-Worms D, Alauddin MM. Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling, and preliminary biological studies of fluoroethyl analogues of crizotinib, alectinib, and ceritinib. Eur J Med Chem. 2019 Nov 15; 182:111571. PMID: 31425908.
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    4. Zacharias NM, Baran N, Shanmugavelandy SS, Lee J, Lujan JV, Dutta P, Millward SW, Cai T, Wood CG, Piwnica-Worms D, Konopleva M, Bhattacharya PK. Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-Time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia. Mol Cancer Ther. 2019 Nov; 18(11):1937-1946. PMID: 31387889.
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    5. Dutta P, Perez MR, Lee J, Kang Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PK. Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer. J Proteome Res. 2019 Jul 05; 18(7):2826-2834. PMID: 31120258.
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    6. Biagiotti G, Pisaneschi F, Gammon ST, Machetti F, Ligi MC, Giambastiani G, Tuci G, Powell E, Piwnica-Worms H, Pranzini E, Paoli P, Cicchi S, Piwnica-Worms D. Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study. J Mater Chem B. 2019 04 28; 7(16):2678-2687. PMID: 31073405.
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    7. Orteca G, Pisaneschi F, Rubagotti S, Liu TW, Biagiotti G, Piwnica-Worms D, Iori M, Capponi PC, Ferrari E, Asti M. Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies. Molecules. 2019 Feb 12; 24(3). PMID: 30759785.
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    8. Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA, Bhattacharya P. Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Mol Imaging Biol. 2019 02; 21(1):86-94. PMID: 29748904.
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    9. Engel BJ, Gammon ST, Chaudhari R, Lu Z, Pisaneschi F, Yang H, Ornelas A, Yan V, Kelderhouse L, Najjar AM, Tong WP, Zhang S, Piwnica-Worms D, Bast RC, Millward SW. Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT. Bioconjug Chem. 2018 09 19; 29(9):3180-3195. PMID: 30168713.
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    10. Zinn PO, Singh SK, Kotrotsou A, Hassan I, Thomas G, Luedi MM, Elakkad A, Elshafeey N, Idris T, Mosley J, Gumin J, Fuller GN, de Groot JF, Baladandayuthapani V, Sulman EP, Kumar AJ, Sawaya R, Lang FF, Piwnica-Worms D, Colen RR. A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models. Clin Cancer Res. 2018 12 15; 24(24):6288-6299. PMID: 30054278.
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    11. Ku G, Huang Q, Wen X, Ye J, Piwnica-Worms D, Li C. Spatial and Temporal Confined Photothermolysis of Cancer Cells Mediated by Hollow Gold Nanospheres Targeted to Epidermal Growth Factor Receptors. ACS Omega. 2018 May 31; 3(5):5888-5895. PMID: 29876540.
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    12. Flentie K, Gonzalez C, Kocher B, Wang Y, Zhu H, Marasa J, Piwnica-Worms D. Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NF?B Activation. Mol Cancer Res. 2018 06; 16(6):986-999. PMID: 29523766.
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    13. Zhao J, Wang H, Hsiao CH, Chow DS, Koay EJ, Kang Y, Wen X, Huang Q, Ma Y, Bankson JA, Ullrich SE, Overwijk W, Maitra A, Piwnica-Worms D, Fleming JB, Li C. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials. 2018 03; 159:215-228. PMID: 29331808.
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    14. Nickless A, Cheruiyot A, Flanagan KC, Piwnica-Worms D, Stewart SA, You Z. p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells. J Biol Chem. 2017 09 15; 292(37):15266-15276. PMID: 28765281.
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    15. Pisaneschi F, Kelderhouse LE, Hardy A, Engel BJ, Mukhopadhyay U, Gonzalez-Lepera C, Gray JP, Ornelas A, Takahashi TT, Roberts RW, Fiacco SV, Piwnica-Worms D, Millward SW. Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers. Bioconjug Chem. 2017 02 15; 28(2):583-589. PMID: 28150941.
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    16. Perera S, Piwnica-Worms D, Alauddin MM. Synthesis of a [(18)F]-labeled ceritinib analogue for positron emission tomography of anaplastic lymphoma kinase, a receptor tyrosine kinase, in lung cancer. J Labelled Comp Radiopharm. 2016 Mar; 59(3):103-8. PMID: 26853088.
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    17. Powell E, Shao J, Yuan Y, Chen HC, Cai S, Echeverria GV, Mistry N, Decker KF, Schlosberg C, Do KA, Edwards JR, Liang H, Piwnica-Worms D, Piwnica-Worms H. p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer. Breast Cancer Res. 2016 Jan 27; 18(1):13. PMID: 26818199.
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    18. Tinkum KL, Stemler KM, White LS, Loza AJ, Jeter-Jones S, Michalski BM, Kuzmicki C, Pless R, Stappenbeck TS, Piwnica-Worms D, Piwnica-Worms H. Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):E7148-54. PMID: 26644583.
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    19. Rosario M, Liu B, Kong L, Collins LI, Schneider SE, Chen X, Han K, Jeng EK, Rhode PR, Leong JW, Schappe T, Jewell BA, Keppel CR, Shah K, Hess B, Romee R, Piwnica-Worms DR, Cashen AF, Bartlett NL, Wong HC, Fehniger TA. The IL-15-Based ALT-803 Complex Enhances Fc?RIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas. Clin Cancer Res. 2016 Feb 01; 22(3):596-608. PMID: 26423796.
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    20. Sengupta R, Barone A, Marasa J, Taylor S, Jackson E, Warrington NM, Rao S, Kim AH, Leonard JR, Piwnica-Worms D, Rubin JB. Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions. Oncotarget. 2015 Jul 30; 6(21):18282-92. PMID: 26286961.
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    21. Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015 Jul 09; 523(7559):177-82. PMID: 26106858.
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    22. Piwnica-Worms D. From the Guest Editor: Illuminating Cancer In Vivo With Molecular Imaging. Cancer J. 2015 May-Jun; 21(3):150-1. PMID: 26049693.
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    23. Eissenberg LG, Rettig MP, Ritchey JK, Prior JL, Schwarz SW, Frye J, White BS, Fulton RS, Ghobadi A, Cooper ML, Couriel DR, Seegulam ME, Piwnica-Worms D, Dehdashti F, Cornetta K, DiPersio JF. [(18)F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility. Mol Ther. 2015 Jun; 23(6):1110-1122. PMID: 25807290.
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    24. Goiffon RJ, Martinez SC, Piwnica-Worms D. A rapid bioluminescence assay for measuring myeloperoxidase activity in human plasma. Nat Commun. 2015 Feb 10; 6:6271. PMID: 25666092.
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    25. Abstracts of the AACR/SNMMI State-of-the-Art Molecular Imaging in Cancer Biology and Therapy, February 11-14, 2015, San Diego, CA. J Nucl Med. 2015 Feb; 56 Suppl 1:3A-28. PMID: 25645299.
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    26. Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS. Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell Host Microbe. 2015 Jan 14; 17(1):85-97. PMID: 25482432.
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    27. Lee Y, Zacharias NM, Piwnica-Worms D, Bhattacharya PK. Chemical reaction-induced multi-molecular polarization (CRIMP). Chem Commun (Camb). 2014 Nov 07; 50(86):13030-3. PMID: 25224323.
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    28. Eissenberg LG, Rettig M, Dehdashti F, Piwnica-Worms D, DiPersio JF. Suicide genes: monitoring cells in patients with a safety switch. Front Pharmacol. 2014; 5:241. PMID: 25414668.
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    29. Barone A, Sengupta R, Warrington NM, Smith E, Wen PY, Brekken RA, Romagnoli B, Douglas G, Chevalier E, Bauer MP, Dembowsky K, Piwnica-Worms D, Rubin JB. Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma. Oncotarget. 2014 Oct 30; 5(20):9811-22. PMID: 25238146.
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    30. Sharma V, Sivapackiam J, Harpstrite SE, Prior JL, Gu H, Rath NP, Piwnica-Worms D. A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion. PLoS One. 2014; 9(10):e109361. PMID: 25353349.
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    31. Kocher BA, White LS, Piwnica-Worms D. DAPK3 suppresses acini morphogenesis and is required for mouse development. Mol Cancer Res. 2015 Feb; 13(2):358-67. PMID: 25304685.
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    32. Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB. PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells. PLoS One. 2014; 9(9):e107397. PMID: 25203500.
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    33. Nickless A, Jackson E, Marasa J, Nugent P, Mercer RW, Piwnica-Worms D, You Z. Intracellular calcium regulates nonsense-mediated mRNA decay. Nat Med. 2014 Aug; 20(8):961-6. PMID: 25064126.
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    34. Hensley H, Devarajan K, Johnson JR, Piwnica-Worms D, Godwin AK, von Mehren M, Rink L. Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging. Cancer Biol Ther. 2014 Jul; 15(7):911-8. PMID: 24755645.
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    35. Elhammali A, Ippolito JE, Collins L, Crowley J, Marasa J, Piwnica-Worms D. A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor. Cancer Discov. 2014 Jul; 4(7):828-39. PMID: 24740997.
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    36. Liu H, Westergard TD, Cashen A, Piwnica-Worms DR, Kunkle L, Vij R, Pham CG, DiPersio J, Cheng EH, Hsieh JJ. Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4. Cancer Cell. 2014 Apr 14; 25(4):530-42. PMID: 24735925.
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    37. Alspach E, Flanagan KC, Luo X, Ruhland MK, Huang H, Pazolli E, Donlin MJ, Marsh T, Piwnica-Worms D, Monahan J, Novack DV, McAllister SS, Stewart SA. p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov. 2014 Jun; 4(6):716-29. PMID: 24670723.
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    38. Powell E, Piwnica-Worms D, Piwnica-Worms H. Contribution of p53 to metastasis. Cancer Discov. 2014 Apr; 4(4):405-14. PMID: 24658082.
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    39. Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG, Spitzer D. Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer. Mol Cancer. 2014 Mar 07; 13:50. PMID: 24602489.
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    40. Qiu X, Johnson JR, Wilson BS, Gammon ST, Piwnica-Worms D, Barnett EM. Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe. PLoS One. 2014; 9(2):e88855. PMID: 24586415.
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    41. Ippolito JE, Piwnica-Worms D. A fluorescence-coupled assay for gamma aminobutyric acid (GABA) reveals metabolic stress-induced modulation of GABA content in neuroendocrine cancer. PLoS One. 2014; 9(2):e88667. PMID: 24551133.
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    42. Garg G, Gibbs J, Belt B, Powell MA, Mutch DG, Goedegebuure P, Collins L, Piwnica-Worms D, Hawkins WG, Spitzer D. Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3. BMC Cancer. 2014 Jan 21; 14:35. PMID: 24447304.
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    43. Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, DiPersio JF, Mardis ER, Gutmann DH. F11R is a novel monocyte prognostic biomarker for malignant glioma. PLoS One. 2013; 8(10):e77571. PMID: 24147027.
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    44. Macdonald-Obermann JL, Adak S, Landgraf R, Piwnica-Worms D, Pike LJ. Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging. J Biol Chem. 2013 Oct 18; 288(42):30773-84. PMID: 24014028.
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    45. Tinkum KL, White LS, Marpegan L, Herzog E, Piwnica-Worms D, Piwnica-Worms H. Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice. J Biol Chem. 2013 Sep 27; 288(39):27999-8008. PMID: 23918930.
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    46. Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R. The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell. 2013 Jun 24; 25(6):585-98. PMID: 23806616.
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    47. Sai KK, Huang C, Yuan L, Zhou D, Piwnica-Worms D, Garbow JR, Engelbach JA, Mach RH, Rich KM, McConathy J. 18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas. J Nucl Med. 2013 Jul; 54(7):1120-6. PMID: 23650628.
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    48. Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD. The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol. 2013 Jun; 15(6):677-87. PMID: 23644467.
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    49. Kocher B, Piwnica-Worms D. Illuminating cancer systems with genetically engineered mouse models and coupled luciferase reporters in vivo. Cancer Discov. 2013 Jun; 3(6):616-29. PMID: 23585416.
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    50. Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV. Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation. Cancer Discov. 2013 Feb; 3(2):212-23. PMID: 23269702.
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    51. Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res. 2013 Feb 01; 73(3):1128-41. PMID: 23221383.
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    52. Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN. The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling. J Clin Invest. 2012 Oct; 122(10):3579-92. PMID: 22996695.
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    53. Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, DiPersio JF. IFN?R signaling mediates alloreactive T-cell trafficking and GVHD. Blood. 2012 Nov 08; 120(19):4093-103. PMID: 22972985.
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    54. Johnson JR, Kocher B, Barnett EM, Marasa J, Piwnica-Worms D. Caspase-activated cell-penetrating peptides reveal temporal coupling between endosomal release and apoptosis in an RGC-5 cell model. Bioconjug Chem. 2012 Sep 19; 23(9):1783-93. PMID: 22900707.
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    55. Li Y, Macdonald-Obermann J, Westfall C, Piwnica-Worms D, Pike LJ. Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization. J Biol Chem. 2012 Sep 07; 287(37):31116-25. PMID: 22822073.
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    56. Moss BL, Elhammali A, Fowlkes T, Gross S, Vinjamoori A, Contag CH, Piwnica-Worms D. Interrogation of inhibitor of nuclear factor ?B a/nuclear factor ?B (I?Ba/NF-?B) negative feedback loop dynamics: from single cells to live animals in vivo. J Biol Chem. 2012 Sep 07; 287(37):31359-70. PMID: 22807442.
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    57. Hurchla MA, Garcia-Gomez A, Hornick MC, Ocio EM, Li A, Blanco JF, Collins L, Kirk CJ, Piwnica-Worms D, Vij R, Tomasson MH, Pandiella A, San Miguel JF, Garayoa M, Weilbaecher KN. The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects. Leukemia. 2013 Feb; 27(2):430-40. PMID: 22763387.
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    58. Chinault SL, Prior JL, Kaltenbronn KM, Penly A, Weilbaecher KN, Piwnica-Worms D, Blumer KJ. Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clin Cancer Res. 2012 Aug 01; 18(15):4136-44. PMID: 22693355.
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    59. Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10; 486(7403):353-60. PMID: 22722193.
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    60. Flentie K, Kocher B, Gammon ST, Novack DV, McKinney JS, Piwnica-Worms D. A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy. Cancer Discov. 2012 Jul; 2(7):624-37. PMID: 22728436.
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    61. Pazolli E, Alspach E, Milczarek A, Prior J, Piwnica-Worms D, Stewart SA. Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res. 2012 May 01; 72(9):2251-61. PMID: 22422937.
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    62. Rao S, Sengupta R, Choe EJ, Woerner BM, Jackson E, Sun T, Leonard J, Piwnica-Worms D, Rubin JB. CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma. PLoS One. 2012; 7(3):e33005. PMID: 22427929.
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    63. Xu Z, Joshi N, Agarwal A, Dahiya S, Bittner P, Smith E, Taylor S, Piwnica-Worms D, Weber J, Leonard JR. Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest. J Neurooncol. 2012 May; 108(1):59-67. PMID: 22382782.
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    64. Piwnica-Worms D. On in vivo imaging in cancer. Cold Spring Harb Perspect Biol. 2012 Mar 01; 4(3). PMID: 22383756.
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    65. Anderson CJ, Piwnica-Worms D. SNM and AACR announce joint conference. J Nucl Med. 2012 Mar; 53(3):18NA. PMID: 22393231.
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    66. Blasberg R, Piwnica-Worms D. Imaging: strategies, controversies, and opportunities. Clin Cancer Res. 2012 Feb 01; 18(3):631-7. PMID: 22298896.
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    67. Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ. Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):137-42. PMID: 22190492.
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    68. Heller E, Hurchla MA, Xiang J, Su X, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior JL, Piwnica-Worms D, Long F, Cagan R, Weilbaecher KN. Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res. 2012 Feb 15; 72(4):897-907. PMID: 22186138.
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    69. Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH, Hsieh JJ. A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res. 2012 Feb 01; 72(3):736-46. PMID: 22166309.
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    70. Woerner BM, Luo J, Brown KR, Jackson E, Dahiya SM, Mischel P, Benovic JL, Piwnica-Worms D, Rubin JB. Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth. Mol Cancer Res. 2012 Jan; 10(1):156-66. PMID: 22086906.
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    71. Fuentealba RA, Marasa J, Diamond MI, Piwnica-Worms D, Weihl CC. An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum Mol Genet. 2012 Feb 01; 21(3):664-80. PMID: 22052286.
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    72. Pasieka TJ, Collins L, O'Connor MA, Chen Y, Parker ZM, Berwin BL, Piwnica-Worms DR, Leib DA. Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in aß? interferon receptor-deficient mice. PLoS One. 2011; 6(9):e24018. PMID: 21915277.
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    73. Dothager RS, Piwnica-Worms D. Nano in cancer: linking chemistry, biology, and clinical applications in vivo. Cancer Res. 2011 Sep 01; 71(17):5611-5. PMID: 21862634.
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    74. Tinkum KL, Marpegan L, White LS, Sun J, Herzog ED, Piwnica-Worms D, Piwnica-Worms H. Bioluminescence imaging captures the expression and dynamics of endogenous p21 promoter activity in living mice and intact cells. Mol Cell Biol. 2011 Sep; 31(18):3759-72. PMID: 21791610.
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    75. Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R. Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal. 2011 Jul 12; 4(181):rs7. PMID: 21775282.
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    76. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. PMID: 21724834.
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    77. Smith BA, Daschbach MM, Gammon ST, Xiao S, Chapman SE, Hudson C, Suckow M, Piwnica-Worms D, Gokel GW, Leevy WM. In vivo cell death mediated by synthetic ion channels. Chem Commun (Camb). 2011 Jul 28; 47(28):7977-9. PMID: 21681307.
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    78. Zhang K, Kim S, Cremasco V, Hirbe AC, Collins L, Piwnica-Worms D, Novack DV, Weilbaecher K, Faccio R. CD8+ T cells regulate bone tumor burden independent of osteoclast resorption. Cancer Res. 2011 Jul 15; 71(14):4799-808. PMID: 21602433.
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    79. Smith BA, Gammon ST, Xiao S, Wang W, Chapman S, McDermott R, Suckow MA, Johnson JR, Piwnica-Worms D, Gokel GW, Smith BD, Leevy WM. In vivo optical imaging of acute cell death using a near-infrared fluorescent zinc-dipicolylamine probe. Mol Pharm. 2011 Apr 04; 8(2):583-90. PMID: 21323375.
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    80. Liu Z, Turkoz A, Jackson EN, Corbo JC, Engelbach JA, Garbow JR, Piwnica-Worms DR, Kopan R. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest. 2011 Feb; 121(2):800-8. PMID: 21266774.
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    81. Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One. 2010 Dec 30; 5(12):e15755. PMID: 21209895.
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    82. Dothager RS, Goiffon RJ, Jackson E, Harpstrite S, Piwnica-Worms D. Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems. PLoS One. 2010 Oct 11; 5(10):e13300. PMID: 20949021.
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    83. Villalobos V, Naik S, Bruinsma M, Dothager RS, Pan MH, Samrakandi M, Moss B, Elhammali A, Piwnica-Worms D. Dual-color click beetle luciferase heteroprotein fragment complementation assays. Chem Biol. 2010 Sep 24; 17(9):1018-29. PMID: 20851351.
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    84. Pan MH, Lin J, Prior JL, Piwnica-Worms D. Monitoring molecular-specific pharmacodynamics of rapamycin in vivo with inducible Gal4->Fluc transgenic reporter mice. Mol Cancer Ther. 2010 Oct; 9(10):2752-60. PMID: 20858726.
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    85. Olanich ME, Moss BL, Piwnica-Worms D, Townsend RR, Weber JD. Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation. Oncogene. 2011 Jan 06; 30(1):77-86. PMID: 20802533.
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    86. Lennerz JK, Hurov JB, White LS, Lewandowski KT, Prior JL, Planer GJ, Gereau RW, Piwnica-Worms D, Schmidt RE, Piwnica-Worms H. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Mol Cell Biol. 2010 Nov; 30(21):5043-56. PMID: 20733003.
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    87. Zhou P, Gross S, Liu JH, Yu BY, Feng LL, Nolta J, Sharma V, Piwnica-Worms D, Qiu SX. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. FASEB J. 2010 Dec; 24(12):4722-32. PMID: 20696856.
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    88. Sun T, Gianino SM, Jackson E, Piwnica-Worms D, Gutmann DH, Rubin JB. CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice. J Neuroimmunol. 2010 Jul 27; 224(1-2):108-13. PMID: 20554030.
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    89. Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, Gutmann DH, Rubin JB. Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1. Cancer Res. 2010 Jul 15; 70(14):5717-27. PMID: 20551058.
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    90. Yang KS, Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ. Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation. J Biol Chem. 2010 Jul 30; 285(31):24014-22. PMID: 20507979.
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    91. Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M. Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice. Cancer Res. 2010 Jun 15; 70(12):4859-67. PMID: 20501835.
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    92. Choi J, Ritchey J, Prior JL, Holt M, Shannon WD, Deych E, Piwnica-Worms DR, DiPersio JF. In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood. 2010 Jul 08; 116(1):129-39. PMID: 20424188.
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    93. Sondergaard CS, Hess DA, Maxwell DJ, Weinheimer C, Rosová I, Creer MH, Piwnica-Worms D, Kovacs A, Pedersen L, Nolta JA. Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction. J Transl Med. 2010 Mar 09; 8:24. PMID: 20214792.
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    94. Liu CC, Prior J, Piwnica-Worms D, Bu G. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5136-41. PMID: 20194742.
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    95. Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH. The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo. Cancer Res. 2010 Feb 15; 70(4):1356-66. PMID: 20124472.
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    96. Piwnica-Worms D, Sharma V. Probing multidrug resistance P-glycoprotein transporter activity with SPECT radiopharmaceuticals. Curr Top Med Chem. 2010; 10(17):1834-45. PMID: 20645914.
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    97. Rauch D, Gross S, Harding J, Bokhari S, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L. T-cell activation promotes tumorigenesis in inflammation-associated cancer. Retrovirology. 2009 Dec 17; 6:116. PMID: 20017942.
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    98. Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer. Clin Cancer Res. 2009 Dec 15; 15(24):7529-7537. PMID: 20008853.
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    99. Ju JS, Fuentealba RA, Miller SE, Jackson E, Piwnica-Worms D, Baloh RH, Weihl CC. Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol. 2009 Dec 14; 187(6):875-88. PMID: 20008565.
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    100. Morgan EA, Schneider JG, Baroni TE, Uluçkan O, Heller E, Hurchla MA, Deng H, Floyd D, Berdy A, Prior JL, Piwnica-Worms D, Teitelbaum SL, Ross FP, Weilbaecher KN. Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit. FASEB J. 2010 Apr; 24(4):1117-27. PMID: 19933310.
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    101. Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Res. 2009 Nov 15; 69(22):8700-9. PMID: 19843867.
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    102. Jost SC, Collins L, Travers S, Piwnica-Worms D, Garbow JR. Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy. Mol Imaging. 2009 Sep-Oct; 8(5):245-53. PMID: 19796602.
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    103. Dothager RS, Piwnica-Worms D. Molecular imaging of pulmonary disease in vivo. Proc Am Thorac Soc. 2009 Aug 15; 6(5):403-10. PMID: 19687211.
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    104. Barnett EM, Zhang X, Maxwell D, Chang Q, Piwnica-Worms D. Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9391-6. PMID: 19458250.
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    105. Carreno BM, Garbow JR, Kolar GR, Jackson EN, Engelbach JA, Becker-Hapak M, Carayannopoulos LN, Piwnica-Worms D, Linette GP. Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases. Clin Cancer Res. 2009 May 15; 15(10):3277-86. PMID: 19447870.
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    106. Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC. Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy. 2009 May; 5(4):511-9. PMID: 19305149.
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    107. Maxwell D, Chang Q, Zhang X, Barnett EM, Piwnica-Worms D. An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging. Bioconjug Chem. 2009 Apr; 20(4):702-9. PMID: 19331388.
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    108. Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA. Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood. 2009 May 21; 113(21):5340-51. PMID: 19324906.
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    109. Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence imaging of myeloperoxidase activity in vivo. Nat Med. 2009 Apr; 15(4):455-61. PMID: 19305414.
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    110. McDunn JE, Muenzer JT, Dunne B, Zhou A, Yuan K, Hoekzema A, Hilliard C, Chang KC, Davis CG, McDonough J, Hunt C, Grigsby P, Piwnica-Worms D, Hotchkiss RS. An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochem Biophys Res Commun. 2009 May 15; 382(4):657-62. PMID: 19303399.
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    111. Uluçkan O, Becker SN, Deng H, Zou W, Prior JL, Piwnica-Worms D, Frazier WA, Weilbaecher KN. CD47 regulates bone mass and tumor metastasis to bone. Cancer Res. 2009 Apr 01; 69(7):3196-204. PMID: 19276363.
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    112. Gammon ST, Villalobos VM, Roshal M, Samrakandi M, Piwnica-Worms D. Rational design of novel red-shifted BRET pairs: Platforms for real-time single-chain protease biosensors. Biotechnol Prog. 2009 Mar-Apr; 25(2):559-69. PMID: 19330851.
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    113. Dothager RS, Flentie K, Moss B, Pan MH, Kesarwala A, Piwnica-Worms D. Advances in bioluminescence imaging of live animal models. Curr Opin Biotechnol. 2009 Feb; 20(1):45-53. PMID: 19233638.
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    114. Kesarwala AH, Samrakandi MM, Piwnica-Worms D. Proteasome inhibition blocks ligand-induced dynamic processing and internalization of epidermal growth factor receptor via altered receptor ubiquitination and phosphorylation. Cancer Res. 2009 Feb 01; 69(3):976-83. PMID: 19176375.
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    115. Yang KS, Ilagan MX, Piwnica-Worms D, Pike LJ. Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor. J Biol Chem. 2009 Mar 20; 284(12):7474-82. PMID: 19171934.
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    116. Hirbe AC, Roelofs AJ, Floyd DH, Deng H, Becker SN, Lanigan LG, Apicelli AJ, Xu Z, Prior JL, Eagleton MC, Piwnica-Worms D, Rogers MJ, Weilbaecher K. The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone. 2009 May; 44(5):908-16. PMID: 19442620.
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    117. Pazolli E, Luo X, Brehm S, Carbery K, Chung JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res. 2009 Feb 01; 69(3):1230-9. PMID: 19155301.
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    118. Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK, Prior JL, Piwnica-Worms D, Bridger G, Ley TJ, DiPersio JF. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood. 2009 Jun 11; 113(24):6206-14. PMID: 19050309.
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    119. Goldhoff P, Warrington NM, Limbrick DD, Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin JB. Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res. 2008 Dec 01; 14(23):7717-25. PMID: 19047098.
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    120. Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L. Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors. Blood. 2009 Feb 12; 113(7):1493-500. PMID: 18971418.
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    121. Pichler A, Prior JL, Luker GD, Piwnica-Worms D. Generation of a highly inducible Gal4-->Fluc universal reporter mouse for in vivo bioluminescence imaging. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15932-7. PMID: 18843112.
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    122. Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. Stably integrated luxCDABE for assessment of Salmonella invasion kinetics. Mol Imaging. 2008 Sep-Oct; 7(5):222-33. PMID: 19123992.
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    123. Parry JJ, Sharma V, Andrews R, Moros EG, Piwnica-Worms D, Rogers BE. PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts. Cancer Gene Ther. 2009 Feb; 16(2):161-70. PMID: 18758434.
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    124. Uluçkan O, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D, Jeong SS, Chen R, Weilbaecher K. APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice. J Cell Biochem. 2008 Jul 01; 104(4):1311-23. PMID: 18260128.
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    125. Leevy WM, Gammon ST, Johnson JR, Lampkins AJ, Jiang H, Marquez M, Piwnica-Worms D, Suckow MA, Smith BD. Noninvasive optical imaging of staphylococcus aureus bacterial infection in living mice using a Bis-dipicolylamine-Zinc(II) affinity group conjugated to a near-infrared fluorophore. Bioconjug Chem. 2008 Mar; 19(3):686-92. PMID: 18260609.
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    126. Zhao L, Kroenke CD, Song J, Piwnica-Worms D, Ackerman JJ, Neil JJ. Intracellular water-specific MR of microbead-adherent cells: the HeLa cell intracellular water exchange lifetime. NMR Biomed. 2008 Feb; 21(2):159-64. PMID: 17461436.
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    127. Moss BL, Gross S, Gammon ST, Vinjamoori A, Piwnica-Worms D. Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling. J Biol Chem. 2008 Mar 28; 283(13):8687-98. PMID: 18203717.
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    128. Zhao L, Sukstanskii AL, Kroenke CD, Song J, Piwnica-Worms D, Ackerman JJ, Neil JJ. Intracellular water specific MR of microbead-adherent cells: HeLa cell intracellular water diffusion. Magn Reson Med. 2008 Jan; 59(1):79-84. PMID: 18050315.
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    129. Villalobos V, Naik S, Piwnica-Worms D. Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation. Methods Mol Biol. 2008; 439:339-52. PMID: 18370114.
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    130. Maxwell DJ, Bonde J, Hess DA, Hohm SA, Lahey R, Zhou P, Creer MH, Piwnica-Worms D, Nolta JA. Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells. Stem Cells. 2008 Feb; 26(2):517-24. PMID: 18055451.
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    131. Naik S, Piwnica-Worms D. Real-time imaging of beta-catenin dynamics in cells and living mice. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17465-70. PMID: 17954915.
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    132. Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity. 2007 Oct; 27(4):635-46. PMID: 17919943.
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    133. Gross S, Moss BL, Piwnica-Worms D. Veni, vidi, vici: in vivo molecular imaging of immune response. Immunity. 2007 Oct; 27(4):533-8. PMID: 17967405.
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    134. McDunn JE, Muenzer JT, Rachdi L, Chang KC, Davis CG, Dunne WM, Piwnica-Worms D, Bernal-Mizrachi E, Hotchkiss RS. Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. FASEB J. 2008 Feb; 22(2):561-8. PMID: 17855622.
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    135. Nervi B, Rettig MP, Ritchey JK, Wang HL, Bauer G, Walker J, Bonyhadi ML, Berenson RJ, Prior JL, Piwnica-Worms D, Nolta JA, DiPersio JF. Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice. Exp Hematol. 2007 Dec; 35(12):1823-38. PMID: 17764813.
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    136. Hirbe AC, Rubin J, Uluçkan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Weilbaecher KN. Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14062-7. PMID: 17715292.
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    137. Gammon ST, Bernstein M, Schuster DP, Piwnica-Worms D. A method for quantification of nucleotides and nucleotide analogues in thymidine kinase assays using lanthanum phosphate coprecipitation. Anal Biochem. 2007 Oct 01; 369(1):80-6. PMID: 17658449.
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    138. Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5680-5. PMID: 17372192.
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    139. Bullok KE, Maxwell D, Kesarwala AH, Gammon S, Prior JL, Snow M, Stanley S, Piwnica-Worms D. Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry. 2007 Apr 03; 46(13):4055-65. PMID: 17348687.
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    140. Gross S, Abraham U, Prior JL, Herzog ED, Piwnica-Worms D. Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo. Mol Imaging. 2007 Mar-Apr; 6(2):121-30. PMID: 17445506.
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    141. Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15; 67(2):651-8. PMID: 17234775.
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    142. Kashiwagi H, McDunn JE, Goedegebuure PS, Gaffney MC, Chang K, Trinkaus K, Piwnica-Worms D, Hotchkiss RS, Hawkins WG. TAT-Bim induces extensive apoptosis in cancer cells. Ann Surg Oncol. 2007 May; 14(5):1763-71. PMID: 17206479.
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    143. Villalobos V, Naik S, Piwnica-Worms D. Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Annu Rev Biomed Eng. 2007; 9:321-49. PMID: 17461729.
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    144. Johnson JR, Fu N, Arunkumar E, Leevy WM, Gammon ST, Piwnica-Worms D, Smith BD. Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging. Angew Chem Int Ed Engl. 2007; 46(29):5528-31. PMID: 17585399.
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    145. Saxena MT, Aton SJ, Hildebolt C, Prior JL, Abraham U, Piwnica-Worms D, Herzog ED. Bioluminescence imaging of period1 gene expression in utero. Mol Imaging. 2007 Jan-Feb; 6(1):68-72. PMID: 17311766.
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    146. Hirbe AC, Uluçkan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Trinkaus K, Apicelli A, Weilbaecher K. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner. Blood. 2007 Apr 15; 109(8):3424-31. PMID: 17192391.
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    147. Leevy WM, Gammon ST, Jiang H, Johnson JR, Maxwell DJ, Jackson EN, Marquez M, Piwnica-Worms D, Smith BD. Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc. 2006 Dec 27; 128(51):16476-7. PMID: 17177377.
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    148. Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene. 2007 Apr 19; 26(18):2563-73. PMID: 17099729.
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    149. Piwnica-Worms D, Kesarwala AH, Pichler A, Prior JL, Sharma V. Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. Neuroimaging Clin N Am. 2006 Nov; 16(4):575-89, viii. PMID: 17148020.
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    150. Kesarwala AH, Prior JL, Sun J, Harpstrite SE, Sharma V, Piwnica-Worms D. Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging. Mol Imaging. 2006 Oct-Dec; 5(4):465-74. PMID: 17150159.
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    151. Ippolito JE, Merritt ME, Bäckhed F, Moulder KL, Mennerick S, Manchester JK, Gammon ST, Piwnica-Worms D, Gordon JI. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12505-10. PMID: 16895983.
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    152. Gross S, Piwnica-Worms D. Molecular imaging strategies for drug discovery and development. Curr Opin Chem Biol. 2006 Aug; 10(4):334-42. PMID: 16822702.
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    153. Barnett EM, Elangovan B, Bullok KE, Piwnica-Worms D. Selective cell uptake of modified Tat peptide-fluorophore conjugates in rat retina in ex vivo and in vivo models. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2589-95. PMID: 16723475.
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    154. Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, Dunne JC, Dietz GP, Bähr M, McDunn JE, Karl IE, Wagner TH, Cobb JP, Coopersmith CM, Piwnica-Worms D. TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol. 2006 May 01; 176(9):5471-7. PMID: 16622015.
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    155. Gammon ST, Leevy WM, Gross S, Gokel GW, Piwnica-Worms D. Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. Anal Chem. 2006 Mar 01; 78(5):1520-7. PMID: 16503603.
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    156. Bullok KE, Gammon ST, Violini S, Prantner AM, Villalobos VM, Sharma V, Piwnica-Worms D. Permeation peptide conjugates for in vivo molecular imaging applications. Mol Imaging. 2006 Jan-Mar; 5(1):1-15. PMID: 16779965.
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    157. Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90. PMID: 16239972.
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    158. Abraham U, Prior JL, Granados-Fuentes D, Piwnica-Worms DR, Herzog ED. Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro. J Neurosci. 2005 Sep 21; 25(38):8620-6. PMID: 16177029.
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    159. Leevy WM, Gammon ST, Levchenko T, Daranciang DD, Murillo O, Torchilin V, Piwnica-Worms D, Huettner JE, Gokel GW. Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells. Org Biomol Chem. 2005 Oct 07; 3(19):3544-50. PMID: 16172693.
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    160. Bullok K, Piwnica-Worms D. Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem. 2005 Aug 25; 48(17):5404-7. PMID: 16107137.
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    161. Gross S, Piwnica-Worms D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods. 2005 Aug; 2(8):607-14. PMID: 16094386.
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    162. Pichler A, Zelcer N, Prior JL, Kuil AJ, Piwnica-Worms D. In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res. 2005 Jun 15; 11(12):4487-94. PMID: 15958634.
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    163. Gillies RJ, Hoffman JM, Lam KS, Menkens AE, Piwnica-Worms DR, Sullivan DC, Weissleder R. Meeting report: high-throughput technologies for in vivo imaging agents. Mol Imaging. 2005 Apr-Jun; 4(2):98-103. PMID: 16105507.
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    164. Sharma V, Prior JL, Belinsky MG, Kruh GD, Piwnica-Worms D. Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors and at the blood-brain barrier. J Nucl Med. 2005 Feb; 46(2):354-64. PMID: 15695797.
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    165. Gross S, Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell. 2005 Jan; 7(1):5-15. PMID: 15652745.
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    166. Bigott HM, Prior JL, Piwnica-Worms DR, Welch MJ. Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-sestamibi. Mol Imaging. 2005 Jan-Mar; 4(1):30-9. PMID: 15967124.
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    167. Gross S, Piwnica-Worms D. Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters. Methods Enzymol. 2005; 399:512-30. PMID: 16338379.
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    168. Piwnica-Worms D, Luker KE. Imaging protein-protein interactions in whole cells and living animals. Ernst Schering Res Found Workshop. 2005; (49):35-41. PMID: 15524209.
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    169. Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D, Luker GD. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res. 2004 Dec 01; 64(23):8604-12. PMID: 15574767.
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    170. Rettig MP, Ritchey JK, Prior JL, Haug JS, Piwnica-Worms D, DiPersio JF. Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantation. J Immunol. 2004 Sep 15; 173(6):3620-30. PMID: 15356106.
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    171. Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12288-93. PMID: 15284440.
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    172. Richard JC, Zhou Z, Chen DL, Mintun MA, Piwnica-Worms D, Factor P, Ponde DE, Schuster DP. Quantitation of pulmonary transgene expression with PET imaging. J Nucl Med. 2004 Apr; 45(4):644-54. PMID: 15073262.
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    173. Piwnica-Worms D, Schuster DP, Garbow JR. Molecular imaging of host-pathogen interactions in intact small animals. Cell Microbiol. 2004 Apr; 6(4):319-31. PMID: 15009024.
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    174. Schuster DP, Kovacs A, Garbow J, Piwnica-Worms D. Recent advances in imaging the lungs of intact small animals. Am J Respir Cell Mol Biol. 2004 Feb; 30(2):129-38. PMID: 14729505.
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    175. Pichler A, Prior JL, Piwnica-Worms D. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1702-7. PMID: 14755051.
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    176. Luker KE, Piwnica-Worms D. Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals. Methods Enzymol. 2004; 385:349-60. PMID: 15130748.
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    177. Zhao H, Doyle TC, Wong RJ, Cao Y, Stevenson DK, Piwnica-Worms D, Contag CH. Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Mol Imaging. 2004 Jan; 3(1):43-54. PMID: 15142411.
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    178. Piwnica-Worms DR. Introduction to molecular imaging. J Am Coll Radiol. 2004 Jan; 1(1 Suppl):2-3. PMID: 17411748.
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    179. Prantner AM, Sharma V, Garbow JR, Piwnica-Worms D. Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets. Mol Imaging. 2003 Oct; 2(4):333-41. PMID: 14717332.
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    180. Luker GD, Pica CM, Song J, Luker KE, Piwnica-Worms D. Imaging 26S proteasome activity and inhibition in living mice. Nat Med. 2003 Jul; 9(7):969-73. PMID: 12819780.
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    181. Luker GD, Sharma V, Pica CM, Prior JL, Li W, Piwnica-Worms D. Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo. Cancer Res. 2003 Apr 15; 63(8):1780-8. PMID: 12702563.
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    182. Gammon ST, Villalobos VM, Prior JL, Sharma V, Piwnica-Worms D. Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: chiral and sequence-specific effects on net cell uptake. Bioconjug Chem. 2003 Mar-Apr; 14(2):368-76. PMID: 12643747.
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    183. Ocheskey JA, Polyakov VR, Harpstrite SE, Oksman A, Goldberg DE, Piwnica-Worms D, Sharma V. Synthesis, characterization, and molecular structure of a gallium(III) complex of an amine-phenol ligand with activity against chloroquine-sensitive Plasmodium falciparum strains. J Inorg Biochem. 2003 Jan 15; 93(3-4):265-70. PMID: 12576290.
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    184. Luker GD, Sharma V, Piwnica-Worms D. Visualizing protein-protein interactions in living animals. Methods. 2003 Jan; 29(1):110-22. PMID: 12543076.
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    185. Richard JC, Zhou Z, Ponde DE, Dence CS, Factor P, Reynolds PN, Luker GD, Sharma V, Ferkol T, Piwnica-Worms D, Schuster DP. Imaging pulmonary gene expression with positron emission tomography. Am J Respir Crit Care Med. 2003 May 01; 167(9):1257-63. PMID: 12505860.
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    186. Luker GD, Bardill JP, Prior JL, Pica CM, Piwnica-Worms D, Leib DA. Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol. 2002 Dec; 76(23):12149-61. PMID: 12414955.
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    187. Bullok KE, Dyszlewski M, Prior JL, Pica CM, Sharma V, Piwnica-Worms D. Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy. Bioconjug Chem. 2002 Nov-Dec; 13(6):1226-37. PMID: 12440857.
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    188. Violini S, Sharma V, Prior JL, Dyszlewski M, Piwnica-Worms D. Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate. Biochemistry. 2002 Oct 22; 41(42):12652-61. PMID: 12379107.
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    189. Sharma V, Luker GD, Piwnica-Worms D. Molecular imaging of gene expression and protein function in vivo with PET and SPECT. J Magn Reson Imaging. 2002 Oct; 16(4):336-51. PMID: 12353250.
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    190. Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6961-6. PMID: 11997447.
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    191. Luker GD, Luker KE, Sharma V, Pica CM, Dahlheimer JL, Ocheskey JA, Fahrner TJ, Milbrandt J, Piwnica-Worms D. In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter. Mol Imaging. 2002 Apr-Jun; 1(2):65-73. PMID: 12920846.
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    192. Dyszlewski M, Blake HM, Dahlheimer JL, Pica CM, Piwnica-Worms D. Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity. Mol Imaging. 2002 Jan-Mar; 1(1):24-35. PMID: 12920858.
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    193. Luker GD, Flagg TP, Sha Q, Luker KE, Pica CM, Nichols CG, Piwnica-Worms D. MDR1 P-glycoprotein reduces influx of substrates without affecting membrane potential. J Biol Chem. 2001 Dec 28; 276(52):49053-60. PMID: 11598111.
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    194. Luker KE, Pica CM, Schreiber RD, Piwnica-Worms D. Overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells. Cancer Res. 2001 Sep 01; 61(17):6540-7. PMID: 11522652.
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    195. Luker GD, Dahlheimer JL, Ostlund RE, Piwnica-Worms D. Decreased hepatic accumulation and enhanced esterification of cholesterol in mice deficient in mdr1a and mdr1b P-glycoproteins. J Lipid Res. 2001 Sep; 42(9):1389-94. PMID: 11518757.
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    196. Slapak CA, Dahlheimer J, Piwnica-Worms D. Reversal of multidrug resistance with LY335979: functional analysis of P-glycoprotein-mediated transport activity and its modulation in vivo. J Clin Pharmacol. 2001 07; 41(S7):29S-38S. PMID: 11452726.
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    197. Luker GD, Piwnica-Worms D. Molecular imaging in vivo with PET and SPECT. Acad Radiol. 2001 Jan; 8(1):4-14. PMID: 11201455.
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    198. Polyakov V, Sharma V, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D. Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy. Bioconjug Chem. 2000 Nov-Dec; 11(6):762-71. PMID: 11087323.
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    199. Tan B, Piwnica-Worms D, Ratner L. Multidrug resistance transporters and modulation. Curr Opin Oncol. 2000 Sep; 12(5):450-8. PMID: 10975553.
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    200. Chen WS, Luker KE, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D. Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin. Biochem Pharmacol. 2000 Aug 01; 60(3):413-26. PMID: 10856437.
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    201. Luker GD, Pica CM, Kumar AS, Covey DF, Piwnica-Worms D. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry. 2000 Jul 04; 39(26):7651-61. PMID: 10869171.
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    202. Sharma V, Beatty A, Wey SP, Dahlheimer J, Pica CM, Crankshaw CL, Bass L, Green MA, Welch MJ, Piwnica-Worms D. Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo. Chem Biol. 2000 May; 7(5):335-43. PMID: 10801474.
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    203. Piwnica-Worms D, Marmion M. Characterization of drug specificity by pharmacokinetic analysis in gene knockout mice. J Clin Pharmacol. 1999 08; 39(S1):30S-33S. PMID: 10434245.
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    204. Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, Piwnica-Worms D. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3900-5. PMID: 10097135.
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    205. Luker GD, Nilsson KR, Covey DF, Piwnica-Worms D. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. J Biol Chem. 1999 Mar 12; 274(11):6979-91. PMID: 10066752.
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    206. Polyakov VR, Sharma V, Crankshaw CL, Piwnica-Worms D. Synthesis, Molecular Structure, and Properties of a Neutral Schiff Base Phenolic Complex of Magnesium. Inorg Chem. 1998 Sep 07; 37(18):4740-4742. PMID: 11670631.
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    207. Rao VV, Herman LW, Kronauge JF, Piwnica-Worms D. A novel areneisonitrile Tc complex inhibits the transport activity of MDR P-glycoprotein. Nucl Med Biol. 1998 Apr; 25(3):225-32. PMID: 9620627.
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    208. Crankshaw CL, Marmion M, Luker GD, Rao V, Dahlheimer J, Burleigh BD, Webb E, Deutsch KF, Piwnica-Worms D. Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDR1) P-glycoprotein. J Nucl Med. 1998 Jan; 39(1):77-86. PMID: 9443741.
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    209. Luker GD, Rao VV, Crankshaw CL, Dahlheimer J, Piwnica-Worms D. Characterization of phosphine complexes of technetium(III) as transport substrates of the multidrug resistance P-glycoprotein and functional markers of P-glycoprotein at the blood-brain barrier. Biochemistry. 1997 Nov 18; 36(46):14218-27. PMID: 9369495.
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    210. Bosch I, Crankshaw CL, Piwnica-Worms D, Croop JM. Characterization of functional assays of multidrug resistance P-glycoprotein transport activity. Leukemia. 1997 Jul; 11(7):1131-7. PMID: 9205002.
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    211. Bae KT, Piwnica-Worms D. Pharmacokinetic modeling of multidrug resistance P-glycoprotein transport of gamma-emitting substrates. Q J Nucl Med. 1997 Jun; 41(2):101-10. PMID: 9203849.
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    212. Goldberg DE, Sharma V, Oksman A, Gluzman IY, Wellems TE, Piwnica-Worms D. Probing the chloroquine resistance locus of Plasmodium falciparum with a novel class of multidentate metal(III) coordination complexes. J Biol Chem. 1997 Mar 07; 272(10):6567-72. PMID: 9045684.
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    213. Luker GD, Fracasso PM, Dobkin J, Piwnica-Worms D. Modulation of the multidrug resistance P-glycoprotein: detection with technetium-99m-sestamibi in vivo. J Nucl Med. 1997 Mar; 38(3):369-72. PMID: 9074520.
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    214. Reimold SC, Maier SE, Aggarwal K, Fleischmann KE, Piwnica-Worms D, Kikinis R, Lee RT. Aortic flow velocity patterns in chronic aortic regurgitation: implications for Doppler echocardiography. J Am Soc Echocardiogr. 1996 Sep-Oct; 9(5):675-83. PMID: 8887871.
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    215. Sharma V, Crankshaw CL, Piwnica-Worms D. Effects of multidrug resistance (MDR1) P-glycoprotein expression levels and coordination metal on the cytotoxic potency of multidentate (N4O2) (ethylenediamine)bis[propyl(R-benzylimino)]metal(III) cations. J Med Chem. 1996 Aug 30; 39(18):3483-90. PMID: 8784446.
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    216. Rao VV, Anthony DC, Piwnica-Worms D. Multidrug resistance P-glycoprotein monoclonal antibody JSB-1 crossreacts with pyruvate carboxylase. J Histochem Cytochem. 1995 Dec; 43(12):1187-92. PMID: 8537634.
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    217. Piwnica-Worms D, Rao VV, Kronauge JF, Croop JM. Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation. Biochemistry. 1995 Sep 26; 34(38):12210-20. PMID: 7547962.
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    218. Baum S, Eckelman WC, Garcia EV, Holman BL, Kung HF, Mattrey RF, Piwnica-Worms D, Wahl RL, Watson JT. Contrast media and radiopharmaceutical agents: regulatory issues. Acad Radiol. 1995 Sep; 2 Suppl 2:S92-3. PMID: 9419707.
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    219. Piwnica-Worms D. In vivo biochemistry, pharmacology, and physiology. Acad Radiol. 1995 Sep; 2 Suppl 2:S98-9. PMID: 9419710.
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    220. Schwartz LH, Seltzer SE, Tempany CM, Silverman SG, Piwnica-Worms DR, Adams DF, Herman L, Herman LA, Hooshmand R. Superparamagnetic iron oxide hepatic MR imaging: efficacy and safety using conventional and fast spin-echo pulse sequences. J Magn Reson Imaging. 1995 Sep-Oct; 5(5):566-70. PMID: 8574043.
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    221. Katzenellenbogen JA, Coleman RE, Hawkins RA, Krohn KA, Larson SM, Mendelsohn J, Osborne CK, Piwnica-Worms D, Reba RC, Siegel BA, et al. Tumor receptor imaging: proceedings of the National Cancer Institute workshop, review of current work, and prospective for further investigations. Clin Cancer Res. 1995 Aug; 1(8):921-32. PMID: 9816063.
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    222. Herman LW, Sharma V, Kronauge JF, Barbarics E, Herman LA, Piwnica-Worms D. Novel hexakis(areneisonitrile)technetium(I) complexes as radioligands targeted to the multidrug resistance P-glycoprotein. J Med Chem. 1995 Jul 21; 38(15):2955-63. PMID: 7636856.
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    223. Piwnica-Worms D. Making sense out of anti-sense: challenges of imaging gene translation with radiolabeled oligonucleotides. J Nucl Med. 1994 Jun; 35(6):1064-6. PMID: 8195871.
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    224. Schwartz LH, Seltzer SE, Adams DF, Tempany CM, Piwnica-Worms DR, Silverman SG, Herman L, Herman LT, Hooshmand R. Effects of superparamagnetic iron oxide (AMI-25) on liver and spleen imaging using spin-echo and fast spin-echo magnetic resonance pulse sequences. Invest Radiol. 1994 Jun; 29 Suppl 2:S21-3. PMID: 7928234.
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    225. Reimold SC, Maier SE, Fleischmann KE, Khatri M, Piwnica-Worms D, Kikinis R, Lee RT. Dynamic nature of the aortic regurgitant orifice area during diastole in patients with chronic aortic regurgitation. Circulation. 1994 May; 89(5):2085-92. PMID: 8181132.
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    226. Rao VV, Anthony DC, Piwnica-Worms D. MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase. Cancer Res. 1994 Mar 15; 54(6):1536-41. PMID: 7511043.
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    227. Rao VV, Chiu ML, Kronauge JF, Piwnica-Worms D. Expression of recombinant human multidrug resistance P-glycoprotein in insect cells confers decreased accumulation of technetium-99m-sestamibi. J Nucl Med. 1994 Mar; 35(3):510-5. PMID: 7906729.
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    228. Piwnica-Worms DP, Kronauge JF, LeFurgey A, Backus M, Hockett D, Ingram P, Lieberman M, Holman BL, Jones AG, Davison A. Mitochondrial localization and characterization of 99Tc-SESTAMIBI in heart cells by electron probe X-ray microanalysis and 99Tc-NMR spectroscopy. Magn Reson Imaging. 1994; 12(4):641-52. PMID: 8057769.
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    229. Schwartz LH, Seltzer SE, Tempany CM, Silverman SG, Piwnica-Worms DR, Adams DF, Herman L, Herman LT, Hooshmand R. Prospective comparison of T2-weighted fast spin-echo, with and without fat suppression, and conventional spin-echo pulse sequences in the upper abdomen. Radiology. 1993 Nov; 189(2):411-6. PMID: 8210368.
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    230. Simons GR, Piwnica-Worms DR, Goldhaber SZ. Ovarian vein thrombosis. Am Heart J. 1993 Sep; 126(3 Pt 1):641-7. PMID: 8362720.
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    231. Backus M, Piwnica-Worms D, Hockett D, Kronauge J, Lieberman M, Ingram P, LeFurgey A. Microprobe analysis of Tc-MIBI in heart cells: calculation of mitochondrial membrane potential. Am J Physiol. 1993 Jul; 265(1 Pt 1):C178-87. PMID: 8338127.
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    232. Chernoff DM, Strichartz GR, Piwnica-Worms D. Membrane potential determination in large unilamellar vesicles with hexakis(2-methoxyisobutylisonitrile)technetium(I). Biochim Biophys Acta. 1993 Apr 22; 1147(2):262-6. PMID: 8476920.
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    233. Piwnica-Worms D, Chiu ML, Budding M, Kronauge JF, Kramer RA, Croop JM. Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res. 1993 Mar 01; 53(5):977-84. PMID: 8094997.
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    234. Piwnica-Worms D, Chiu ML, Kronauge JF. Detection of adriamycin-induced cardiotoxicity in cultured heart cells with technetium 99m-SESTAMIBI. Cancer Chemother Pharmacol. 1993; 32(5):385-91. PMID: 8339390.
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    235. Chiu ML, Herman LW, Kronauge JF, Piwnica-Worms D. Comparative effects of neutral dipolar compounds and lipophilic anions on technetium 99m-hexakis (2-methoxyisobutyl isonitrile) accumulation in cultured chick ventricular myocytes. Invest Radiol. 1992 Dec; 27(12):1052-8. PMID: 1473924.
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    236. Patz EF, Shaffer K, Piwnica-Worms DR, Jochelson M, Sarin M, Sugarbaker DJ, Pugatch RD. Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability. AJR Am J Roentgenol. 1992 Nov; 159(5):961-6. PMID: 1414807.
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    237. Carvalho PA, Chiu ML, Kronauge JF, Kawamura M, Jones AG, Holman BL, Piwnica-Worms D. Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts. J Nucl Med. 1992 Aug; 33(8):1516-22. PMID: 1634944.
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    238. Piwnica-Worms D, Chiu ML, Kronauge JF. Divergent kinetics of 201Tl and 99mTc-SESTAMIBI in cultured chick ventricular myocytes during ATP depletion. Circulation. 1992 Apr; 85(4):1531-41. PMID: 1313342.
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    239. Kandarpa K, Piwnica-Worms D, Chopra PS, Admas DF, Hunink MG, Donaldson MC, Whittemore AD, Mannick JA, Harrington DP. Prospective double-blinded comparison of MR imaging and aortography in the preoperative evaluation of abdominal aortic aneurysms. J Vasc Interv Radiol. 1992 Feb; 3(1):83-9. PMID: 1540717.
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    240. Kronauge JF, Chiu ML, Cone JS, Davison A, Holman BL, Jones AG, Piwnica-Worms D. Comparison of neutral and cationic myocardial perfusion agents: characteristics of accumulation in cultured cells. Int J Rad Appl Instrum B. 1992 Feb; 19(2):141-8. PMID: 1601667.
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    241. Piwnica-Worms D, Kronauge JF, Chiu ML. Enhancement by tetraphenylborate of technetium-99m-MIBI uptake kinetics and accumulation in cultured chick myocardial cells. J Nucl Med. 1991 Oct; 32(10):1992-9. PMID: 1919744.
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    242. Klein MA, Winalski CS, Wax MR, Piwnica-Worms DR. MR imaging of septic sacroiliitis. J Comput Assist Tomogr. 1991 Jan-Feb; 15(1):126-32. PMID: 1987181.
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    243. Liu S, Piwnica-Worms D, Lieberman M. Intracellular pH regulation in cultured embryonic chick heart cells. Na(+)-dependent Cl-/HCO3- exchange. J Gen Physiol. 1990 Dec; 96(6):1247-69. PMID: 1962815.
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    244. Piwnica-Worms D, Kronauge JF, Chiu ML. Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium(I) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence. Circulation. 1990 Nov; 82(5):1826-38. PMID: 2225379.
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    245. Chiu ML, Kronauge JF, Piwnica-Worms D. Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxyisobutylisonitrile) technetium(I) in cultured mouse fibroblasts. J Nucl Med. 1990 Oct; 31(10):1646-53. PMID: 2213187.
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    246. Piwnica-Worms D, Holman BL. Noncardiac applications of hexakis(alkylisonitrile) technetium-99m complexes. J Nucl Med. 1990 Jul; 31(7):1166-7. PMID: 2362196.
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    247. Delmon-Moingeon LI, Piwnica-Worms D, Van den Abbeele AD, Holman BL, Davison A, Jones AG. Uptake of the cation hexakis(2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cell lines in vitro. Cancer Res. 1990 Apr 01; 50(7):2198-202. PMID: 2317808.
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    248. Piwnica-Worms D, Kronauge JF, Delmon L, Holman BL, Marsh JD, Jones AG. Effect of metabolic inhibition on technetium-99m-MIBI kinetics in cultured chick myocardial cells. J Nucl Med. 1990 Apr; 31(4):464-72. PMID: 2324822.
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    249. Liu S, Jacob R, Piwnica-Worms D, Lieberman M. Interaction of (Na + K + 2 Cl) cotransport and the Na/K pump in cultured chick cardiac myocytes. Mol Cell Biochem. 1989 Sep 07; 89(2):147-50. PMID: 2811863.
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    250. Piwnica-Worms D, Kronauge JF, Holman BL, Davison A, Jones AG. Comparative myocardial uptake characteristics of hexakis (alkylisonitrile) technetium(I) complexes. Effect of lipophilicity. Invest Radiol. 1989 Jan; 24(1):25-9. PMID: 2917819.
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    251. Piwnica-Worms D, Kronauge JF, Holman BL, Lister-James J, Davison A, Jones AG. Hexakis(carbomethoxyisopropylisonitrile) technetium(I), a new myocardial perfusion imaging agent: binding characteristics in cultured chick heart cells. J Nucl Med. 1988 Jan; 29(1):55-61. PMID: 3335928.
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    252. Liu S, Jacob R, Piwnica-Worms D, Lieberman M. (Na + K + 2Cl) cotransport in cultured embryonic chick heart cells. Am J Physiol. 1987 Nov; 253(5 Pt 1):C721-30. PMID: 3688219.
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    253. Jacob R, Lieberman M, Murphy E, Piwnica-Worms D. Effects of sodium-potassium pump inhibition and low sodium on membrane potential in cultured embryonic chick heart cells. J Physiol. 1987 Jun; 387:549-66. PMID: 2443685.
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    254. Piwnica-Worms D, Jacob R, Shigeto N, Horres CR, Lieberman M. Na/H exchange in cultured chick heart cells: secondary stimulation of electrogenic transport during recovery from intracellular acidosis. J Mol Cell Cardiol. 1986 Nov; 18(11):1109-16. PMID: 3025458.
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    255. Piwnica-Worms D, Forman A, Tumeh SS. Chronic ear discharge in an elderly diabetic man. Invest Radiol. 1986 Jul; 21(7):584-8. PMID: 3488299.
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    256. Jacob R, Piwnica-Worms D, Horres CR, Lieberman M. Electroneutral Na/H exchange may depolarize the membrane potential in steady state. J Gen Physiol. 1985 Dec; 86(6):891-5. PMID: 2416872.
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    257. Piwnica-Worms D, Jacob R, Horres CR, Lieberman M. Potassium-chloride cotransport in cultured chick heart cells. Am J Physiol. 1985 Sep; 249(3 Pt 1):C337-44. PMID: 4037074.
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    258. Piwnica-Worms D, Jacob R, Horres CR, Lieberman M. Na/H exchange in cultured chick heart cells. pHi regulation. J Gen Physiol. 1985 Jan; 85(1):43-64. PMID: 3968533.
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