COBI JACOBA JOHANNA HEIJNEN

TitleProfessor
InstitutionMD Anderson
DepartmentSymptom Research CAO
Address1515 Holcombe Blvd.
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lacourt TE, Kavelaars A, Tripathy D, Heijnen CJ. Associations between fatigue and cellular metabolism in breast cancer patients: A longitudinal study. Psychoneuroendocrinology. 2022 10; 144:105866. PMID: 35853380.
      Citations:    Fields:    
    2. Singh SK, Krukowski K, Laumet GO, Weis D, Alexander JF, Heijnen CJ, Kavelaars A. CD8+ T cell-derived IL-13 increases macrophage IL-10 to resolve neuropathic pain. JCI Insight. 2022 03 08; 7(5). PMID: 35260535.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Singh AK, Mahalingam R, Squillace S, Jacobson KA, Tosh DK, Dharmaraj S, Farr SA, Kavelaars A, Salvemini D, Heijnen CJ. Targeting the A3 adenosine receptor to prevent and reverse chemotherapy-induced neurotoxicities in mice. Acta Neuropathol Commun. 2022 01 29; 10(1):11. PMID: 35093182.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Alexander JF, Mahalingam R, Seua AV, Wu S, Arroyo LD, Hörbelt T, Schedlowski M, Blanco E, Kavelaars A, Heijnen CJ. Targeting the Meningeal Compartment to Resolve Chemobrain and Neuropathy via Nasal Delivery of Functionalized Mitochondria. Adv Healthc Mater. 2022 04; 11(8):e2102153. PMID: 35007407.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. McAlpin BR, Mahalingam R, Singh AK, Dharmaraj S, Chrisikos TT, Boukelmoune N, Kavelaars A, Heijnen CJ. HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity. Theranostics. 2022; 12(2):603-619. PMID: 34976203.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Zhang J, Ma J, Trinh RT, Heijnen CJ, Kavelaars A. An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway. Brain Behav Immun. 2022 02; 100:287-296. PMID: 34915156.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" [Biochem. Pharmacol. 192 (2021) 114688]. Biochem Pharmacol. 2022 Jan; 195:114860. PMID: 34864607.
      Citations:    Fields:    
    8. Walker JG, Armstrong TS, O'Brien BJ, Gilbert MR, Casarez RL, Fagundes C, Heijnen CJ, Andersen CR, Yuan Y, Wu J, LoBiondo-Wood G. Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis. Compr Psychoneuroendocrinol. 2021 Nov; 8:100099. PMID: 35757676.
      Citations:    
    9. Kavelaars A, Heijnen CJ. Immune regulation of pain: Friend and foe. Sci Transl Med. 2021 11 10; 13(619):eabj7152. PMID: 34757809.
      Citations: 2     Fields:    Translation:HumansCells
    10. Ma J, Goodwani S, Acton PJ, Buggia-Prevot V, Kesler SR, Jamal I, Mahant ID, Liu Z, Mseeh F, Roth BL, Chakraborty C, Peng B, Wu Q, Jiang Y, Le K, Soth MJ, Jones P, Kavelaars A, Ray WJ, Heijnen CJ. Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments. Pain. 2021 10 01; 162(10):2599-2612. PMID: 33872235.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Kasembeli MM, Singhmar P, Ma J, Edralin J, Tang Y, Adams C, Heijnen CJ, Kavelaars A, Tweardy DJ. TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain. Biochem Pharmacol. 2021 10; 192:114688. PMID: 34274354.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Wang XS, Shi Q, Mendoza TR, Garcia-Gonzalez A, Chen TY, Kamal M, Chen TH, Heijnen C, Orlowski RZ, Cleeland CS. Minocycline for symptom reduction in patients with multiple myeloma during maintenance therapy: a phase II placebo-controlled randomized trial. Support Care Cancer. 2021 Oct; 29(10):6099-6107. PMID: 33792800.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    13. Lacagnina MJ, Heijnen CJ, Watkins LR, Grace PM. Autoimmune regulation of chronic pain. Pain Rep. 2021; 6(1):e905. PMID: 33981931.
      Citations: 3     
    14. Boukelmoune N, Laumet G, Tang Y, Ma J, Mahant I, Singh SK, Nijboer C, Benders M, Kavelaars A, Heijnen CJ. Nasal administration of mesenchymal stem cells reverses chemotherapy-induced peripheral neuropathy in mice. Brain Behav Immun. 2021 03; 93:43-54. PMID: 33316379.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    15. Chiang ACA, Seua AV, Singhmar P, Arroyo LD, Mahalingam R, Hu J, Kavelaars A, Heijnen CJ. Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice. Acta Neuropathol Commun. 2020 11 12; 8(1):193. PMID: 33183353.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Laumet G, Bavencoffe A, Edralin JD, Huo XJ, Walters ET, Dantzer R, Heijnen CJ, Kavelaars A. Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability. Pain. 2020 10; 161(10):2344-2352. PMID: 32427749.
      Citations: 15     Fields:    Translation:AnimalsCells
    17. Lacourt TE, Heijnen CJ, Manzullo EF, Escalante C. A central role for apathy in the effectiveness of interventions for cancer-related fatigue. Psychooncology. 2020 10; 29(10):1613-1619. PMID: 32658377.
      Citations:    Fields:    Translation:Humans
    18. English K, Shepherd A, Uzor NE, Trinh R, Kavelaars A, Heijnen CJ. Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer. Acta Neuropathol Commun. 2020 03 20; 8(1):36. PMID: 32197663.
      Citations: 14     Fields:    Translation:AnimalsCells
    19. Singhmar P, Trinh RTP, Ma J, Huo X, Peng B, Heijnen CJ, Kavelaars A. The fibroblast-derived protein PI16 controls neuropathic pain. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5463-5471. PMID: 32079726.
      Citations: 14     Fields:    Translation:AnimalsCells
    20. Lopez RB, Brown RL, Wu EL, Murdock KW, Denny BT, Heijnen C, Fagundes C. Emotion Regulation and Immune Functioning During Grief: Testing the Role of Expressive Suppression and Cognitive Reappraisal in Inflammation Among Recently Bereaved Spouses. Psychosom Med. 2020 01; 82(1):2-9. PMID: 31634318.
      Citations: 6     Fields:    Translation:Humans
    21. Wang XS, Shi Q, Bhadkamkar NA, Cleeland CS, Garcia-Gonzalez A, Aguilar JR, Heijnen C, Eng C. Minocycline for Symptom Reduction During Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Phase II Randomized Clinical Trial. J Pain Symptom Manage. 2019 10; 58(4):662-671. PMID: 31254639.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    22. Laumet G, Edralin JD, Dantzer R, Heijnen CJ, Kavelaars A. Cisplatin educates CD8+ T cells to prevent and resolve chemotherapy-induced peripheral neuropathy in mice. Pain. 2019 06; 160(6):1459-1468. PMID: 30720585.
      Citations: 24     Fields:    Translation:AnimalsCells
    23. Chiang ACA, Huo X, Kavelaars A, Heijnen CJ. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain Behav Immun. 2019 07; 79:319-325. PMID: 30953771.
      Citations: 12     Fields:    Translation:Animals
    24. Boukelmoune N, Chiu GS, Kavelaars A, Heijnen CJ. Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin. Acta Neuropathol Commun. 2018 12 12; 6(1):139. PMID: 30541620.
      Citations: 31     Fields:    Translation:AnimalsCells
    25. Huo X, Reyes TM, Heijnen CJ, Kavelaars A. Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice. Sci Rep. 2018 11 27; 8(1):17400. PMID: 30479361.
      Citations: 12     Fields:    Translation:AnimalsCells
    26. Chiu GS, Boukelmoune N, Chiang ACA, Peng B, Rao V, Kingsley C, Liu HL, Kavelaars A, Kesler SR, Heijnen CJ. Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice. Oncotarget. 2018 Oct 30; 9(85):35581-35597. PMID: 30473752.
      Citations: 25     Fields:    
    27. Fagundes CP, Brown RL, Chen MA, Murdock KW, Saucedo L, LeRoy A, Wu EL, Garcini LM, Shahane AD, Baameur F, Heijnen C. Grief, depressive symptoms, and inflammation in the spousally bereaved. Psychoneuroendocrinology. 2019 02; 100:190-197. PMID: 30368120.
      Citations: 14     Fields:    Translation:Humans
    28. Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ. Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. Acta Neuropathol Commun. 2018 10 01; 6(1):103. PMID: 30270813.
      Citations: 21     Fields:    Translation:AnimalsCells
    29. Lacourt TE, Kavelaars A, Ohanian M, Shah ND, Shelburne SA, Futreal A, Kontoyiannis DP, Heijnen CJ. Patient-reported fatigue prior to treatment is prognostic of survival in patients with acute myeloid leukemia. Oncotarget. 2018 Jul 27; 9(58):31244-31252. PMID: 30131851.
      Citations: 4     Fields:    
    30. Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology. 2018 12; 43(13):2597-2605. PMID: 30054585.
      Citations: 22     Fields:    Translation:AnimalsCells
    31. Lacourt TE, Vichaya EG, Escalante C, Manzullo EF, Gunn B, Hess KR, Heijnen CJ, Dantzer R. An effort expenditure perspective on cancer-related fatigue. Psychoneuroendocrinology. 2018 10; 96:109-117. PMID: 29929087.
      Citations: 6     Fields:    Translation:Humans
    32. Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A. Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy. Pain. 2018 May; 159(5):884-893. PMID: 29369966.
      Citations: 22     Fields:    Translation:AnimalsCells
    33. Vichaya EG, Laumet G, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R. Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase. Neuropsychopharmacology. 2019 01; 44(2):364-371. PMID: 29760410.
      Citations: 9     Fields:    Translation:Animals
    34. Lacourt TE, Vichaya EG, Chiu GS, Dantzer R, Heijnen CJ. The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure. Front Behav Neurosci. 2018; 12:78. PMID: 29755330.
      Citations: 33     
    35. Fagundes CP, Murdock KW, LeRoy A, Baameur F, Thayer JF, Heijnen C. Spousal bereavement is associated with more pronounced ex vivo cytokine production and lower heart rate variability: Mechanisms underlying cardiovascular risk? Psychoneuroendocrinology. 2018 07; 93:65-71. PMID: 29702444.
      Citations: 18     Fields:    Translation:Humans
    36. Lacourt TE, Kavelaars A, Galloway-Peña JR, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ. Associations of inflammation with symptom burden in patients with acute myeloid leukemia. Psychoneuroendocrinology. 2018 03; 89:203-208. PMID: 29414033.
      Citations: 4     Fields:    Translation:Humans
    37. Ma J, Kavelaars A, Dougherty PM, Heijnen CJ. Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source. Cancer. 2018 06 01; 124(11):2289-2298. PMID: 29461625.
      Citations: 51     Fields:    Translation:HumansCells
    38. Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O'Connor JC, Lee AW, Heijnen CJ, Kavelaars A. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain Behav Immun. 2017 Nov; 66:94-102. PMID: 28709913.
      Citations: 32     Fields:    Translation:AnimalsCells
    39. Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, van Duzer JH, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain. 2017 06; 158(6):1126-1137. PMID: 28267067.
      Citations: 57     Fields:    Translation:Animals
    40. Lacourt TE, Heijnen CJ. Mechanisms of Neurotoxic Symptoms as a Result of Breast Cancer and Its Treatment: Considerations on the Contribution of Stress, Inflammation, and Cellular Bioenergetics. Curr Breast Cancer Rep. 2017; 9(2):70-81. PMID: 28616125.
      Citations: 17     
    41. Maj MA, Ma J, Krukowski KN, Kavelaars A, Heijnen CJ. Inhibition of Mitochondrial p53 Accumulation by PFT-µ Prevents Cisplatin-Induced Peripheral Neuropathy. Front Mol Neurosci. 2017; 10:108. PMID: 28458631.
      Citations: 32     
    42. Chiu GS, Maj MA, Rizvi S, Dantzer R, Vichaya EG, Laumet G, Kavelaars A, Heijnen CJ. Pifithrin-µ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function. Cancer Res. 2017 02 01; 77(3):742-752. PMID: 27879267.
      Citations: 36     Fields:    Translation:AnimalsCells
    43. Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A. Epac1 interacts with importin ß1 and controls neurite outgrowth independently of cAMP and Rap1. Sci Rep. 2016 11 03; 6:36370. PMID: 27808165.
      Citations: 9     Fields:    Translation:HumansCells
    44. Zhou W, Kavelaars A, Heijnen CJ. Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice. PLoS One. 2016; 11(3):e0151890. PMID: 27018597.
      Citations: 56     Fields:    Translation:AnimalsCells
    45. Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F, Murga C, Heijnen CJ, Kavelaars A. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3036-41. PMID: 26929333.
      Citations: 56     Fields:    Translation:AnimalsCells
    46. Krukowski K, Nijboer CH, Huo X, Kavelaars A, Heijnen CJ. Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-µ. Pain. 2015 Nov; 156(11):2184-2192. PMID: 26473292.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    47. Vichaya EG, Molkentine JM, Vermeer DW, Walker AK, Feng R, Holder G, Luu K, Mason RM, Saligan L, Heijnen CJ, Kavelaars A, Mason KA, Lee JH, Dantzer R. Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression. Behav Brain Res. 2016 Jan 15; 297:241-50. PMID: 26475509.
      Citations: 12     Fields:    Translation:AnimalsCells
    48. Vichaya EG, Chiu GS, Krukowski K, Lacourt TE, Kavelaars A, Dantzer R, Heijnen CJ, Walker AK. Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci. 2015; 9:131. PMID: 25954147.
      Citations: 66     
    49. Zhou W, Dantzer R, Budac DP, Walker AK, Mao-Ying QL, Lee AW, Heijnen CJ, Kavelaars A. Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun. 2015 May; 46:147-53. PMID: 25637485.
      Citations: 21     Fields:    Translation:Animals
    50. Donega V, Nijboer CH, Braccioli L, Slaper-Cortenbach I, Kavelaars A, van Bel F, Heijnen CJ. Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions. PLoS One. 2014; 9(11):e112339. PMID: 25396420.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    51. Ter Wolbeek M, Kavelaars A, de Vries WB, Tersteeg-Kamperman M, Veen S, Kornelisse RF, van Weissenbruch M, Baerts W, Liem KD, van Bel F, Heijnen CJ. Neonatal glucocorticoid treatment: long-term effects on the hypothalamus-pituitary-adrenal axis, immune system, and problem behavior in 14-17 year old adolescents. Brain Behav Immun. 2015 Mar; 45:128-38. PMID: 25449580.
      Citations: 9     Fields:    Translation:Humans
    52. van Zuiden M, Kavelaars A, Vermetten E, Olff M, Geuze E, Heijnen C. Pre-deployment differences in glucocorticoid sensitivity of leukocytes in soldiers developing symptoms of PTSD, depression or fatigue persist after return from military deployment. Psychoneuroendocrinology. 2015 Jan; 51:513-24. PMID: 25277845.
      Citations: 11     Fields:    Translation:HumansCells
    53. Smid GE, van Zuiden M, Geuze E, Kavelaars A, Heijnen CJ, Vermetten E. Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers. Psychoneuroendocrinology. 2015 Jan; 51:534-46. PMID: 25106657.
      Citations: 14     Fields:    Translation:Humans
    54. Mao-Ying QL, Kavelaars A, Krukowski K, Huo XJ, Zhou W, Price TJ, Cleeland C, Heijnen CJ. The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model. PLoS One. 2014; 9(6):e100701. PMID: 24955774.
      Citations: 74     Fields:    Translation:AnimalsCells
    55. Donega V, Nijboer CH, van Tilborg G, Dijkhuizen RM, Kavelaars A, Heijnen CJ. Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury. Exp Neurol. 2014 Nov; 261:53-64. PMID: 24945601.
      Citations: 62     Fields:    Translation:AnimalsCells
    56. Willemen HL, Eijkelkamp N, Garza Carbajal A, Wang H, Mack M, Zijlstra J, Heijnen CJ, Kavelaars A. Monocytes/Macrophages control resolution of transient inflammatory pain. J Pain. 2014 May; 15(5):496-506. PMID: 24793056.
      Citations: 50     Fields:    Translation:AnimalsCells
    57. Willemen HL, Campos PM, Lucas E, Morreale A, Gil-Redondo R, Agut J, González FV, Ramos P, Heijnen C, Mayor F, Kavelaars A, Murga C. A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia. Biochem J. 2014 May 01; 459(3):427-39. PMID: 24517375.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    58. Brouwers C, Versteeg H, Meine M, Heijnen CJ, Kavelaars AM, Pedersen SS, Mommersteeg PM. Association between brain natriuretic peptide, markers of inflammation and the objective and subjective response to cardiac resynchronization therapy. Brain Behav Immun. 2014 Aug; 40:211-8. PMID: 24704567.
      Citations: 4     Fields:    Translation:Humans
    59. Wang XS, Shi Q, Shah ND, Heijnen CJ, Cohen EN, Reuben JM, Orlowski RZ, Qazilbash MH, Johnson VE, Williams LA, Mendoza TR, Cleeland CS. Inflammatory markers and development of symptom burden in patients with multiple myeloma during autologous stem cell transplantation. Clin Cancer Res. 2014 Mar 01; 20(5):1366-74. PMID: 24423611.
      Citations: 33     Fields:    Translation:Humans
    60. Kooijman E, Nijboer CH, van Velthoven CT, Kavelaars A, Kesecioglu J, Heijnen CJ. The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies. J Neuroinflammation. 2014 Jan 03; 11:2. PMID: 24386932.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    61. Walker AK, Kavelaars A, Heijnen CJ, Dantzer R. Neuroinflammation and comorbidity of pain and depression. Pharmacol Rev. 2014; 66(1):80-101. PMID: 24335193.
      Citations: 131     Fields:    Translation:HumansAnimals
    62. Wang H, Heijnen CJ, van Velthoven CT, Willemen HL, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, Kavelaars A. Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. J Clin Invest. 2013 Dec; 123(12):5023-34. PMID: 24231349.
      Citations: 50     Fields:    Translation:AnimalsCells
    63. Dantzer R, Heijnen CJ, Kavelaars A, Laye S, Capuron L. The neuroimmune basis of fatigue. Trends Neurosci. 2014 Jan; 37(1):39-46. PMID: 24239063.
      Citations: 97     Fields:    Translation:HumansAnimals
    64. van Velthoven CT, Braccioli L, Willemen HL, Kavelaars A, Heijnen CJ. Therapeutic potential of genetically modified mesenchymal stem cells after neonatal hypoxic-ischemic brain damage. Mol Ther. 2014 Mar; 22(3):645-654. PMID: 24172866.
      Citations: 20     Fields:    Translation:AnimalsCells
    65. Hoogendam JP, Zaal A, Rutten EG, Heijnen CJ, Kenter GG, Veldhuis WB, Verheijen RH, Zweemer RP. Detection of cervical cancer recurrence during follow-up: a multivariable comparison of 9 frequently investigated serum biomarkers. Gynecol Oncol. 2013 Dec; 131(3):655-60. PMID: 24157617.
      Citations: 3     Fields:    Translation:Humans
    66. Weimar CH, Post Uiterweer ED, Teklenburg G, Heijnen CJ, Macklon NS. In-vitro model systems for the study of human embryo-endometrium interactions. Reprod Biomed Online. 2013 Nov; 27(5):461-76. PMID: 24055530.
      Citations: 31     Fields:    Translation:HumansCells
    67. Gordijn MS, Gemke RJ, Bierings MB, Hoogerbrugge PM, Tersteeg-Kamperman MD, Heijnen CJ, Rotteveel J, Kaspers GJ. Adequate endocrine and cardiovascular response to social stress in survivors of childhood acute lymphoblastic leukemia. Psychoneuroendocrinology. 2013 Dec; 38(12):3145-9. PMID: 23972944.
      Citations:    Fields:    Translation:Humans
    68. Nessler J, Bénardais K, Gudi V, Hoffmann A, Salinas Tejedor L, Janßen S, Prajeeth CK, Baumgärtner W, Kavelaars A, Heijnen CJ, van Velthoven C, Hansmann F, Skripuletz T, Stangel M. Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination. PLoS One. 2013; 8(7):e69795. PMID: 23922802.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    69. Braccioli L, van Velthoven C, Heijnen CJ. Exosomes: a new weapon to treat the central nervous system. Mol Neurobiol. 2014 Feb; 49(1):113-9. PMID: 23857502.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    70. Bonestroo HJ, Nijboer CH, van Velthoven CT, Kavelaars A, Hack CE, van Bel F, Heijnen CJ. Cerebral and hepatic inflammatory response after neonatal hypoxia-ischemia in newborn rats. Dev Neurosci. 2013; 35(2-3):197-211. PMID: 23689428.
      Citations: 29     Fields:    Translation:Animals
    71. van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM. Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. Stroke. 2013 May; 44(5):1426-32. PMID: 23539530.
      Citations: 86     Fields:    Translation:AnimalsCells
    72. Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P. G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Ann Neurol. 2013 May; 73(5):667-78. PMID: 23494575.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    73. Hegeman MA, Hennus MP, Cobelens PM, Kavelaars A, Jansen NJ, Schultz MJ, van Vught AJ, Heijnen CJ. Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury. PLoS One. 2013; 8(2):e57374. PMID: 23451215.
      Citations: 15     Fields:    Translation:Animals
    74. Cheong Y, Boomsma C, Heijnen C, Macklon N. Uterine secretomics: a window on the maternal-embryo interface. Fertil Steril. 2013 Mar 15; 99(4):1093-9. PMID: 23433513.
      Citations: 16     Fields:    Translation:HumansCells
    75. Donega V, van Velthoven CT, Nijboer CH, Kavelaars A, Heijnen CJ. The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment. J Cereb Blood Flow Metab. 2013 May; 33(5):625-34. PMID: 23403379.
      Citations: 24     Fields:    Translation:HumansAnimals
    76. Nijboer CH, Bonestroo HJ, Zijlstra J, Kavelaars A, Heijnen CJ. Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage. Neurobiol Dis. 2013 Jun; 54:432-44. PMID: 23376684.
      Citations: 32     Fields:    Translation:AnimalsCells
    77. Nijboer CH, Heijnen CJ, Degos V, Willemen HL, Gressens P, Kavelaars A. Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage. Neurobiol Dis. 2013 Jun; 54:206-15. PMID: 23313319.
      Citations: 6     Fields:    Translation:AnimalsCells
    78. Donega V, van Velthoven CT, Nijboer CH, van Bel F, Kas MJ, Kavelaars A, Heijnen CJ. Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement. PLoS One. 2013; 8(1):e51253. PMID: 23300948.
      Citations: 68     Fields:    Translation:AnimalsCells
    79. ter Wolbeek M, de Sonneville LM, de Vries WB, Kavelaars A, Veen S, Kornelisse RF, van Weissenbruch M, Baerts W, Liem KD, van Bel F, Heijnen CJ. Early life intervention with glucocorticoids has negative effects on motor development and neuropsychological function in 14-17 year-old adolescents. Psychoneuroendocrinology. 2013 Jul; 38(7):975-86. PMID: 23107421.
      Citations: 8     Fields:    Translation:Humans
    80. Fan X, van Bel F, van der Kooij MA, Heijnen CJ, Groenendaal F. Hypothermia and erythropoietin for neuroprotection after neonatal brain damage. Pediatr Res. 2013 Jan; 73(1):18-23. PMID: 23085819.
      Citations: 36     Fields:    Translation:Animals
    81. Otten JJ, de Jager SC, Kavelaars A, Seijkens T, Bot I, Wijnands E, Beckers L, Westra MM, Bot M, Busch M, Bermudez B, van Berkel TJ, Heijnen CJ, Biessen EA. Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice. FASEB J. 2013 Jan; 27(1):265-76. PMID: 23047899.
      Citations: 12     Fields:    Translation:Animals
    82. van Zuiden M, Kavelaars A, Geuze E, Olff M, Heijnen CJ. Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions. Brain Behav Immun. 2013 May; 30:12-21. PMID: 22981834.
      Citations: 43     Fields:    Translation:HumansCells
    83. Kan AA, de Jager W, de Wit M, Heijnen C, van Zuiden M, Ferrier C, van Rijen P, Gosselaar P, Hessel E, van Nieuwenhuizen O, de Graan PN. Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines. J Neuroinflammation. 2012 Aug 30; 9:207. PMID: 22935090.
      Citations: 27     Fields:    Translation:HumansCells
    84. van Zuiden M, Kavelaars A, Amarouchi K, Maas M, Vermetten E, Geuze E, Heijnen CJ. IL-1ß reactivity and the development of severe fatigue after military deployment: a longitudinal study. J Neuroinflammation. 2012 Aug 21; 9:205. PMID: 22908999.
      Citations: 4     Fields:    Translation:HumansCells
    85. Weimar CH, Kavelaars A, Brosens JJ, Gellersen B, de Vreeden-Elbertse JM, Heijnen CJ, Macklon NS. Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos. PLoS One. 2012; 7(7):e41424. PMID: 22848492.
      Citations: 41     Fields:    Translation:HumansCellsCTClinical Trials
    86. Willemen HL, Huo XJ, Mao-Ying QL, Zijlstra J, Heijnen CJ, Kavelaars A. MicroRNA-124 as a novel treatment for persistent hyperalgesia. J Neuroinflammation. 2012 Jun 25; 9:143. PMID: 22731384.
      Citations: 70     Fields:    Translation:AnimalsCells
    87. van Velthoven CT, van de Looij Y, Kavelaars A, Zijlstra J, van Bel F, Huppi PS, Sizonenko S, Heijnen CJ. Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice. Ann Neurol. 2012 Jun; 71(6):785-96. PMID: 22718545.
      Citations: 34     Fields:    Translation:AnimalsCells
    88. Eijkelkamp N, Heijnen CJ, Carbajal AG, Willemen HL, Wang H, Minett MS, Wood JN, Schedlowski M, Dantzer R, Kelley KW, Kavelaars A. G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling. Mol Med. 2012 May 09; 18:556-64. PMID: 22331028.
      Citations: 15     Fields:    Translation:AnimalsCells
    89. van Zuiden M, Heijnen CJ, Maas M, Amarouchi K, Vermetten E, Geuze E, Kavelaars A. Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: A prospective study. Psychoneuroendocrinology. 2012 Nov; 37(11):1822-36. PMID: 22503138.
      Citations: 29     Fields:    Translation:HumansCells
    90. Geuze E, van Wingen GA, van Zuiden M, Rademaker AR, Vermetten E, Kavelaars A, Fernández G, Heijnen CJ. Glucocorticoid receptor number predicts increase in amygdala activity after severe stress. Psychoneuroendocrinology. 2012 Nov; 37(11):1837-44. PMID: 22503140.
      Citations: 8     Fields:    Translation:HumansCells
    91. Heijnen CJ, Witt O, Wulffraat N, Kulozik AE. Stem cells in pediatrics: state of the art and future perspectives. Pediatr Res. 2012 Apr; 71(4 Pt 2):407-9. PMID: 22430377.
      Citations: 2     Fields:    Translation:Humans
    92. Teklenburg G, Weimar CH, Fauser BC, Macklon N, Geijsen N, Heijnen CJ, Chuva de Sousa Lopes SM, Kuijk EW. Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation. PLoS One. 2012; 7(3):e32701. PMID: 22412909.
      Citations: 10     Fields:    Translation:HumansCells
    93. Gordijn MS, van Litsenburg RR, Gemke RJ, Bierings MB, Hoogerbrugge PM, van de Ven PM, Heijnen CJ, Kaspers GJ. Hypothalamic-pituitary-adrenal axis function in survivors of childhood acute lymphoblastic leukemia and healthy controls. Psychoneuroendocrinology. 2012 Sep; 37(9):1448-56. PMID: 22385687.
      Citations: 5     Fields:    Translation:Humans
    94. van Velthoven CT, Kavelaars A, Heijnen CJ. Mesenchymal stem cells as a treatment for neonatal ischemic brain damage. Pediatr Res. 2012 Apr; 71(4 Pt 2):474-81. PMID: 22430383.
      Citations: 62     Fields:    Translation:HumansCells
    95. van Zuiden M, Heijnen CJ, van de Schoot R, Amarouchi K, Maas M, Vermetten E, Geuze E, Kavelaars A. Cytokine production by leukocytes of military personnel with depressive symptoms after deployment to a combat-zone: a prospective, longitudinal study. PLoS One. 2011; 6(12):e29142. PMID: 22195009.
      Citations: 15     Fields:    Translation:HumansCells
    96. van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Amarouchi K, Kavelaars A, Heijnen CJ. Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study. Biol Psychiatry. 2012 Feb 15; 71(4):309-16. PMID: 22137507.
      Citations: 72     Fields:    Translation:Humans
    97. Rijpert M, Breur JM, Evers IM, de Valk HW, Heijnen CJ, Meijboom FJ, Visser GH. Cardiac function in 7-8-year-old offspring of women with type 1 diabetes. Exp Diabetes Res. 2011; 2011:564316. PMID: 22144987.
      Citations: 4     Fields:    Translation:Humans
    98. Korenromp IH, Grutters JC, van den Bosch JM, Heijnen CJ. Post-inflammatory fatigue in sarcoidosis: personality profiles, psychological symptoms and stress hormones. J Psychosom Res. 2012 Feb; 72(2):97-102. PMID: 22281449.
      Citations: 2     Fields:    Translation:Humans
    99. Titomanlio L, Kavelaars A, Dalous J, Mani S, El Ghouzzi V, Heijnen C, Baud O, Gressens P. Stem cell therapy for neonatal brain injury: perspectives and challenges. Ann Neurol. 2011 Nov; 70(5):698-712. PMID: 22162055.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    100. Widerøe M, Brekken C, Kavelaars A, Pedersen TB, Goa PE, Heijnen C, Skranes J, Brubakk AM. Longitudinal manganese-enhanced magnetic resonance imaging of delayed brain damage after hypoxic-ischemic injury in the neonatal rat. Neonatology. 2011; 100(4):363-72. PMID: 21791927.
      Citations: 9     Fields:    Translation:AnimalsCells
    101. Hegeman MA, Cobelens PM, Kamps J, Hennus MP, Jansen NJ, Schultz MJ, van Vught AJ, Molema G, Heijnen CJ. Liposome-encapsulated dexamethasone attenuates ventilator-induced lung inflammation. Br J Pharmacol. 2011 Jul; 163(5):1048-58. PMID: 21391981.
      Citations: 13     Fields:    Translation:Animals
    102. van Velthoven CT, Heijnen CJ, van Bel F, Kavelaars A. Osteopontin enhances endogenous repair after neonatal hypoxic-ischemic brain injury. Stroke. 2011 Aug; 42(8):2294-301. PMID: 21700938.
      Citations: 35     Fields:    Translation:AnimalsCells
    103. Nijboer CH, Heijnen CJ, van der Kooij MA, Zijlstra J, van Velthoven CT, Culmsee C, van Bel F, Hagberg H, Kavelaars A. Targeting the p53 pathway to protect the neonatal ischemic brain. Ann Neurol. 2011 Aug; 70(2):255-64. PMID: 21674585.
      Citations: 47     Fields:    Translation:AnimalsCells
    104. Korenromp IH, Grutters JC, van den Bosch JM, Zanen P, Kavelaars A, Heijnen CJ. Reduced Th2 cytokine production by sarcoidosis patients in clinical remission with chronic fatigue. Brain Behav Immun. 2011 Oct; 25(7):1498-502. PMID: 21693184.
      Citations: 7     Fields:    Translation:HumansCells
    105. Mommersteeg PM, Denollet J, Kavelaars A, Geuze E, Vermetten E, Heijnen CJ. Type D personality, temperament, and mental health in military personnel awaiting deployment. Int J Behav Med. 2011 Jun; 18(2):131-8. PMID: 20473600.
      Citations: 4     Fields:    Translation:Humans
    106. ter Wolbeek M, van Doornen LJ, Kavelaars A, Tersteeg-Kamperman MD, Heijnen CJ. Fatigue, depressive symptoms, and anxiety from adolescence up to young adulthood: a longitudinal study. Brain Behav Immun. 2011 Aug; 25(6):1249-55. PMID: 21549830.
      Citations: 13     Fields:    Translation:Humans
    107. Wang H, Heijnen CJ, Eijkelkamp N, Carbajal AG, Schedlowski M, Kelley KW, Dantzer R, Kavelaars A. GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia. Pain. 2011 Jul; 152(7):1649-1658. PMID: 21514055.
      Citations: 26     Fields:    Translation:AnimalsCells
    108. Kavelaars A, Eijkelkamp N, Willemen HL, Wang H, Carbajal AG, Heijnen CJ. Microglial GRK2: a novel regulator of transition from acute to chronic pain. Brain Behav Immun. 2011 Aug; 25(6):1055-60. PMID: 21473908.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    109. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain. Brain Behav Immun. 2011 Oct; 25(7):1342-8. PMID: 21473911.
      Citations: 45     Fields:    Translation:AnimalsCells
    110. Korenromp IHE, Heijnen CJ, Vogels OJM, van den Bosch JMM, Grutters JC. Characterization of chronic fatigue in patients with sarcoidosis in clinical remission. Chest. 2011 Aug; 140(2):441-447. PMID: 21330380.
      Citations: 21     Fields:    Translation:Humans
    111. de Jager SC, Bermúdez B, Bot I, Koenen RR, Bot M, Kavelaars A, de Waard V, Heijnen CJ, Muriana FJ, Weber C, van Berkel TJ, Kuiper J, Lee SJ, Abia R, Biessen EA. Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis. J Exp Med. 2011 Feb 14; 208(2):217-25. PMID: 21242297.
      Citations: 74     Fields:    Translation:AnimalsCells
    112. Fan X, Heijnen CJ, van der KOOIJ MA, Groenendaal F, van Bel F. Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice. Pediatr Res. 2011 Jan; 69(1):56-61. PMID: 20856165.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    113. van Zuiden M, Kavelaars A, Rademaker AR, Vermetten E, Heijnen CJ, Geuze E. A prospective study on personality and the cortisol awakening response to predict posttraumatic stress symptoms in response to military deployment. J Psychiatr Res. 2011 Jun; 45(6):713-9. PMID: 21185572.
      Citations: 11     Fields:    Translation:Humans
    114. Fluitman SB, Heijnen CJ, Denys DA, Nolen WA, Balk FJ, Westenberg HG. Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder. J Affect Disord. 2011 Jun; 131(1-3):388-92. PMID: 21183225.
      Citations: 22     Fields:    Translation:HumansCells
    115. Hegeman MA, Hennus MP, van Meurs M, Cobelens PM, Kavelaars A, Jansen NJ, Schultz MJ, van Vught AJ, Molema G, Heijnen CJ. Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury. PLoS One. 2010 Dec 14; 5(12):e15653. PMID: 21179479.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    116. Rijpert M, Evers IM, de Valk HW, de Vroede MA, Tersteeg-Kamperman M, Heijnen CJ, Visser GH. Cardiovascular and metabolic outcome in 6-8 year old offspring of women with type 1 diabetes with near-optimal glycaemic control during pregnancy. Early Hum Dev. 2011 Jan; 87(1):49-54. PMID: 21095079.
      Citations: 3     Fields:    Translation:Humans
    117. van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Heijnen CJ, Kavelaars A. Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment. Am J Psychiatry. 2011 Jan; 168(1):89-96. PMID: 21078706.
      Citations: 70     Fields:    Translation:Humans
    118. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Nasal administration of stem cells: a promising novel route to treat neonatal ischemic brain damage. Pediatr Res. 2010 Nov; 68(5):419-22. PMID: 20639794.
      Citations: 71     Fields:    Translation:AnimalsCells
    119. Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ, Kavelaars A. Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci. 2010 Sep 22; 30(38):12806-15. PMID: 20861385.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    120. Teklenburg G, Salker M, Heijnen C, Macklon NS, Brosens JJ. The molecular basis of recurrent pregnancy loss: impaired natural embryo selection. Mol Hum Reprod. 2010 Dec; 16(12):886-95. PMID: 20847090.
      Citations: 46     Fields:    Translation:Humans
    121. Cobelens PM, Tiebosch IA, Dijkhuizen RM, van der Meide PH, Zwartbol R, Heijnen CJ, Kesecioglu J, van den Bergh WM. Interferon-ß attenuates lung inflammation following experimental subarachnoid hemorrhage. Crit Care. 2010; 14(4):R157. PMID: 20731855.
      Citations: 18     Fields:    Translation:Animals
    122. Riether C, Kavelaars A, Wirth T, Pacheco-López G, Doenlen R, Willemen H, Heijnen CJ, Schedlowski M, Engler H. Stimulation of ß2-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction. Brain Behav Immun. 2011 Jan; 25(1):59-66. PMID: 20674738.
      Citations: 16     Fields:    Translation:AnimalsCells
    123. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function. J Neurosci. 2010 Jul 14; 30(28):9603-11. PMID: 20631189.
      Citations: 73     Fields:    Translation:AnimalsCells
    124. Willemen HLDM, Eijkelkamp N, Wang H, Dantzer R, Dorn GW, Kelley KW, Heijnen CJ, Kavelaars A. Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain. 2010 Sep; 150(3):550-560. PMID: 20609517.
      Citations: 54     Fields:    Translation:AnimalsCells
    125. van Venrooij JA, Fluitman SB, Lijmer JG, Kavelaars A, Heijnen CJ, Westenberg HG, Kahn RS, Gispen-de Wied CC. Impaired neuroendocrine and immune response to acute stress in medication-naive patients with a first episode of psychosis. Schizophr Bull. 2012 Mar; 38(2):272-9. PMID: 20558533.
      Citations: 26     Fields:    Translation:HumansCells
    126. Fluitman S, Denys D, Vulink N, Schutters S, Heijnen C, Westenberg H. Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder. Psychiatry Res. 2010 Jul 30; 178(2):313-6. PMID: 20452055.
      Citations: 11     Fields:    Translation:HumansCells
    127. Laan W, Grobbee DE, Selten JP, Heijnen CJ, Kahn RS, Burger H. Adjuvant aspirin therapy reduces symptoms of schizophrenia spectrum disorders: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2010 May; 71(5):520-7. PMID: 20492850.
      Citations: 88     Fields:    Translation:HumansCells
    128. Salker M, Teklenburg G, Molokhia M, Lavery S, Trew G, Aojanepong T, Mardon HJ, Lokugamage AU, Rai R, Landles C, Roelen BA, Quenby S, Kuijk EW, Kavelaars A, Heijnen CJ, Regan L, Macklon NS, Brosens JJ. Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One. 2010 Apr 21; 5(4):e10287. PMID: 20422017.
      Citations: 111     Fields:    Translation:HumansCells
    129. Teklenburg G, Salker M, Molokhia M, Lavery S, Trew G, Aojanepong T, Mardon HJ, Lokugamage AU, Rai R, Landles C, Roelen BA, Quenby S, Kuijk EW, Kavelaars A, Heijnen CJ, Regan L, Brosens JJ, Macklon NS. Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One. 2010 Apr 21; 5(4):e10258. PMID: 20422011.
      Citations: 81     Fields:    Translation:HumansCells
    130. Boomsma CM, Kavelaars A, Bozkurt N, Eijkemans MJ, Fauser BC, Heijnen CJ, Macklon NS. Is bacterial vaginosis associated with a pro-inflammatory cytokine profile in endometrial secretions of women undergoing IVF? Reprod Biomed Online. 2010 Jul; 21(1):133-41. PMID: 20580898.
      Citations: 2     Fields:    Translation:Humans
    131. Eijkelkamp N, Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, Dorn GW, Wood JN, Kavelaars A. GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci. 2010 Feb 10; 30(6):2138-49. PMID: 20147541.
      Citations: 55     Fields:    Translation:AnimalsCells
    132. Heijnen CJ, Kavelaars A. Neuro-immune, behavioral and molecular aspects of brain damage. Brain Behav Immun. 2010 Jul; 24(5):705-7. PMID: 20138140.
      Citations: 1     Fields:    Translation:HumansAnimals
    133. van der Kooij MA, Nijboer CH, Ohl F, Groenendaal F, Heijnen CJ, van Bel F, Kavelaars A. NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats. Neurobiol Dis. 2010 May; 38(2):266-72. PMID: 20132887.
      Citations: 20     Fields:    Translation:AnimalsCells
    134. Fluitman SB, Denys DA, Heijnen CJ, Westenberg HG. Disgust affects TNF-alpha, IL-6 and noradrenalin levels in patients with obsessive-compulsive disorder. Psychoneuroendocrinology. 2010 Jul; 35(6):906-11. PMID: 20044210.
      Citations: 8     Fields:    Translation:Humans
    135. Boomsma CM, Kavelaars A, Eijkemans MJ, Fauser BC, Heijnen CJ, Macklon NS. Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo. Fertil Steril. 2010 Oct; 94(5):1764-8. PMID: 20004388.
      Citations: 23     Fields:    Translation:Humans
    136. Nijboer CH, Heijnen CJ, Willemen HL, Groenendaal F, Dorn GW, van Bel F, Kavelaars A. Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice. Brain Behav Immun. 2010 Mar; 24(3):420-6. PMID: 19932746.
      Citations: 20     Fields:    Translation:AnimalsCells
    137. Hegeman MA, Hennus MP, Heijnen CJ, Specht PA, Lachmann B, Jansen NJ, van Vught AJ, Cobelens PM. Ventilator-induced endothelial activation and inflammation in the lung and distal organs. Crit Care. 2009; 13(6):R182. PMID: 19917112.
      Citations: 32     Fields:    Translation:Animals
    138. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration. Brain Behav Immun. 2010 Mar; 24(3):387-93. PMID: 19883750.
      Citations: 85     Fields:    Translation:AnimalsCells
    139. Fan X, Heijnen CJ, van der Kooij MA, Groenendaal F, van Bel F. The role and regulation of hypoxia-inducible factor-1alpha expression in brain development and neonatal hypoxic-ischemic brain injury. Brain Res Rev. 2009 Dec 11; 62(1):99-108. PMID: 19786048.
      Citations: 79     Fields:    Translation:HumansAnimals
    140. Nijboer CH, van der Kooij MA, van Bel F, Ohl F, Heijnen CJ, Kavelaars A. Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury. Brain Behav Immun. 2010 Jul; 24(5):812-21. PMID: 19766183.
      Citations: 44     Fields:    Translation:AnimalsCells
    141. van der Kooij MA, Ohl F, Arndt SS, Kavelaars A, van Bel F, Heijnen CJ. Mild neonatal hypoxia-ischemia induces long-term motor- and cognitive impairments in mice. Brain Behav Immun. 2010 Jul; 24(5):850-6. PMID: 19748566.
      Citations: 17     Fields:    Translation:Animals
    142. Rijpert M, Evers IM, de Vroede MA, de Valk HW, Heijnen CJ, Visser GH. Risk factors for childhood overweight in offspring of type 1 diabetic women with adequate glycemic control during pregnancy: Nationwide follow-up study in the Netherlands. Diabetes Care. 2009 Nov; 32(11):2099-104. PMID: 19651922.
      Citations: 20     Fields:    Translation:Humans
    143. van Zuiden M, Geuze E, Maas M, Vermetten E, Heijnen CJ, Kavelaars A. Deployment-related severe fatigue with depressive symptoms is associated with increased glucocorticoid binding to peripheral blood mononuclear cells. Brain Behav Immun. 2009 Nov; 23(8):1132-9. PMID: 19635550.
      Citations: 7     Fields:    Translation:HumansCells
    144. Nijboer CH, Heijnen CJ, Groenendaal F, van Bel F, Kavelaars A. Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia. Stroke. 2009 Oct; 40(10):3362-8. PMID: 19628795.
      Citations: 24     Fields:    Translation:AnimalsCells
    145. van Velthoven CT, Kavelaars A, van Bel F, Heijnen CJ. Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes. Brain Res Rev. 2009 Jun; 61(1):1-13. PMID: 19348860.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    146. van Putte BP, Cobelens PM, van der Kaaij N, Lachmann B, Kavelaars A, Heijnen CJ, Kesecioglu J. Exogenous surfactant attenuation of ischemia-reperfusion injury in the lung through alteration of inflammatory and apoptotic factors. J Thorac Cardiovasc Surg. 2009 Apr; 137(4):824-8. PMID: 19327503.
      Citations: 6     Fields:    Translation:Animals
    147. van Bel F, Heijnen CJ. Perinatal programming and reprogramming by glucocorticoid therapy and perinatal stress. Semin Fetal Neonatal Med. 2009 Jun; 14(3):127-9. PMID: 19246269.
      Citations: 2     Fields:    Translation:HumansAnimals
    148. Boomsma CM, Kavelaars A, Eijkemans MJ, Lentjes EG, Fauser BC, Heijnen CJ, Macklon NS. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod. 2009 Jun; 24(6):1427-35. PMID: 19228761.
      Citations: 43     Fields:    Translation:HumansCTClinical Trials
    149. van Houdenhove B, Heijnen CJ. [Chronic fatigue syndrome: a psychoneuroimmunological perspective]. Tijdschr Psychiatr. 2009; 51(8):603-10. PMID: 19658073.
      Citations: 2     Fields:    Translation:Humans
    150. Boomsma CM, Kavelaars A, Eijkemans MJ, Amarouchi K, Teklenburg G, Gutknecht D, Fauser BJ, Heijnen CJ, Macklon NS. Cytokine profiling in endometrial secretions: a non-invasive window on endometrial receptivity. Reprod Biomed Online. 2009 Jan; 18(1):85-94. PMID: 19146774.
      Citations: 21     Fields:    Translation:Humans
    151. Widerøe M, Olsen Ø, Pedersen TB, Goa PE, Kavelaars A, Heijnen C, Skranes J, Brubakk AM, Brekken C. Manganese-enhanced magnetic resonance imaging of hypoxic-ischemic brain injury in the neonatal rat. Neuroimage. 2009 Apr 15; 45(3):880-90. PMID: 19138750.
      Citations: 21     Fields:    Translation:AnimalsCells
    152. Pacheco-López G, Riether C, Doenlen R, Engler H, Niemi MB, Engler A, Kavelaars A, Heijnen CJ, Schedlowski M. Calcineurin inhibition in splenocytes induced by pavlovian conditioning. FASEB J. 2009 Apr; 23(4):1161-7. PMID: 19103649.
      Citations: 10     Fields:    Translation:AnimalsCells
    153. van der Kooij MA, Groenendaal F, Kavelaars A, Heijnen CJ, van Bel F. Combination of deferoxamine and erythropoietin: therapy for hypoxia-ischemia-induced brain injury in the neonatal rat? Neurosci Lett. 2009 Feb 20; 451(2):109-13. PMID: 19103262.
      Citations: 16     Fields:    Translation:AnimalsCells
    154. Karemaker R, Karemaker JM, Kavelaars A, Tersteeg-Kamperman M, Baerts W, Veen S, Samsom JF, van Bel F, Heijnen CJ. Effects of neonatal dexamethasone treatment on the cardiovascular stress response of children at school age. Pediatrics. 2008 Nov; 122(5):978-87. PMID: 18977976.
      Citations: 7     Fields:    Translation:Humans
    155. Kuiper JW, Versteilen AM, Niessen HW, Vaschetto RR, Sipkema P, Heijnen CJ, Groeneveld AB, Plötz FB. Production of endothelin-1 and reduced blood flow in the rat kidney during lung-injurious mechanical ventilation. Anesth Analg. 2008 Oct; 107(4):1276-83. PMID: 18806040.
      Citations: 6     Fields:    Translation:Animals
    156. van Mourik MS, Macklon NS, Heijnen CJ. Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. J Leukoc Biol. 2009 Jan; 85(1):4-19. PMID: 18784344.
      Citations: 104     Fields:    Translation:HumansCells
    157. de Vries WB, Karemaker R, Mooy NF, Strengers JL, Kemperman H, Baerts W, Veen S, Visser GH, Heijnen CJ, van Bel F. Cardiovascular follow-up at school age after perinatal glucocorticoid exposure in prematurely born children: perinatal glucocorticoid therapy and cardiovascular follow-up. Arch Pediatr Adolesc Med. 2008 Aug; 162(8):738-44. PMID: 18678806.
      Citations: 4     Fields:    Translation:Humans
    158. Eijkelkamp N, Heijnen CJ, Elsenbruch S, Holtmann G, Schedlowski M, Kavelaars A. G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia. Brain Behav Immun. 2009 Jan; 23(1):18-26. PMID: 18687398.
      Citations: 10     Fields:    Translation:AnimalsCells
    159. Mommersteeg PM, Vermetten E, Kavelaars A, Geuze E, Heijnen CJ. Hostility is related to clusters of T-cell cytokines and chemokines in healthy men. Psychoneuroendocrinology. 2008 Sep; 33(8):1041-50. PMID: 18640786.
      Citations: 17     Fields:    Translation:HumansCells
    160. Cobelens PM, van Putte BP, Kavelaars A, Heijnen CJ, Kesecioglu J. Inflammatory consequences of lung ischemia-reperfusion injury and low-pressure ventilation. J Surg Res. 2009 May 15; 153(2):295-301. PMID: 18952232.
      Citations: 14     Fields:    Translation:Animals
    161. van der Kooij MA, Groenendaal F, Kavelaars A, Heijnen CJ, van Bel F. Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia. Brain Res Rev. 2008 Nov; 59(1):22-33. PMID: 18514916.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    162. Nijboer CH, Heijnen CJ, Groenendaal F, May MJ, van Bel F, Kavelaars A. Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines. Stroke. 2008 Jul; 39(7):2129-37. PMID: 18420952.
      Citations: 54     Fields:    Translation:AnimalsCells
    163. Nijboer CH, Heijnen CJ, Groenendaal F, May MJ, van Bel F, Kavelaars A. A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage. Stroke. 2008 Sep; 39(9):2578-86. PMID: 18420947.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    164. Karemaker R, Kavelaars A, ter Wolbeek M, Tersteeg-Kamperman M, Baerts W, Veen S, Samsom JF, Visser GH, van Bel F, Heijnen CJ. Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age. Pediatrics. 2008 Apr; 121(4):e870-8. PMID: 18381516.
      Citations: 22     Fields:    Translation:Humans
    165. Penela P, Ribas C, Aymerich I, Eijkelkamp N, Barreiro O, Heijnen CJ, Kavelaars A, Sánchez-Madrid F, Mayor F. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008 Apr 23; 27(8):1206-18. PMID: 18369319.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    166. Nijboer CH, Kavelaars A, Vroon A, Groenendaal F, van Bel F, Heijnen CJ. Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage. J Neurosci. 2008 Mar 26; 28(13):3324-32. PMID: 18367599.
      Citations: 18     Fields:    Translation:AnimalsCells
    167. ter Wolbeek M, van Doornen LJ, Kavelaars A, Heijnen CJ. Predictors of persistent and new-onset fatigue in adolescent girls. Pediatrics. 2008 Mar; 121(3):e449-57. PMID: 18310166.
      Citations: 13     Fields:    Translation:Humans
    168. ter Wolbeek M, van Doornen LJ, Schedlowski M, Janssen OE, Kavelaars A, Heijnen CJ. Glucocorticoid sensitivity of immune cells in severely fatigued adolescent girls: a longitudinal study. Psychoneuroendocrinology. 2008 Apr; 33(3):375-85. PMID: 18242001.
      Citations: 3     Fields:    Translation:HumansCells
    169. de Kloet C, Vermetten E, Lentjes E, Geuze E, van Pelt J, Manuel R, Heijnen C, Westenberg H. Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder. Psychoneuroendocrinology. 2008 Apr; 33(3):313-20. PMID: 18215470.
      Citations: 11     Fields:    Translation:Humans
    170. Mommersteeg PM, Heijnen CJ, Kavelaars A, van Doornen LJ. The HPA-axis and immune function in burnout. Prog Brain Res. 2008; 167:281-5. PMID: 18037026.
      Citations: 3     Fields:    Translation:Humans
    171. de Kloet CS, Vermetten E, Geuze E, Lentjes EG, Heijnen CJ, Stalla GK, Westenberg HG. Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder. Prog Brain Res. 2008; 167:287-91. PMID: 18037027.
      Citations: 41     Fields:    Translation:Humans
    172. van Runnard Heimel PJ, Kavelaars A, Heijnen CJ, Peters WH, Huisjes AJ, Franx A, Bruinse HW. HELLP syndrome is associated with an increased inflammatory response, which may be inhibited by administration of prednisolone. Hypertens Pregnancy. 2008; 27(3):253-65. PMID: 18696354.
      Citations: 11     Fields:    Translation:Humans
    173. Kleibeuker W, Jurado-Pueyo M, Murga C, Eijkelkamp N, Mayor F, Heijnen CJ, Kavelaars A. Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium. J Neurochem. 2008 Feb; 104(4):979-92. PMID: 17971124.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    174. Langhorst J, Cobelens PM, Kavelaars A, Heijnen CJ, Benson S, Rifaie N, Dobos GJ, Schedlowski M, Elsenbruch S. Stress-related peripheral neuroendocrine-immune interactions in women with ulcerative colitis. Psychoneuroendocrinology. 2007 Sep-Nov; 32(8-10):1086-96. PMID: 17933470.
      Citations: 8     Fields:    Translation:HumansCells
    175. Kleibeuker W, Gabay E, Kavelaars A, Zijlstra J, Wolf G, Ziv N, Yirmiya R, Shavit Y, Tal M, Heijnen CJ. IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2. Brain Behav Immun. 2008 Feb; 22(2):200-8. PMID: 17869478.
      Citations: 30     Fields:    Translation:AnimalsCells
    176. Eijkelkamp N, Kavelaars A, Elsenbruch S, Schedlowski M, Holtmann G, Heijnen CJ. Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior. Am J Physiol Gastrointest Liver Physiol. 2007 Oct; 293(4):G749-57. PMID: 17656446.
      Citations: 33     Fields:    Translation:Animals
    177. Houtveen JH, Kavelaars A, Heijnen CJ, van Doornen LJ. Heterogeneous medically unexplained symptoms and immune function. Brain Behav Immun. 2007 Nov; 21(8):1075-82. PMID: 17553664.
      Citations: 3     Fields:    Translation:HumansCells
    178. ter Wolbeek M, van Doornen LJ, Kavelaars A, van de Putte EM, Schedlowski M, Heijnen CJ. Longitudinal analysis of pro- and anti-inflammatory cytokine production in severely fatigued adolescents. Brain Behav Immun. 2007 Nov; 21(8):1063-74. PMID: 17544255.
      Citations: 22     Fields:    Translation:HumansCells
    179. Elsenbruch S, Haag S, Lucas A, Riemenschneider N, Pietsch A, Gerken G, Heijnen CJ, Schedlowski M, Holtmann G. Neuroendocrine and blood pressure responses to rectal distensions in individuals with high and low visceral pain sensitivity. Psychoneuroendocrinology. 2007 Jun; 32(5):580-5. PMID: 17482372.
      Citations: 1     Fields:    Translation:Humans
    180. Lombardi MS, Vroon A, Sodaar P, van Muiswinkel FL, Heijnen CJ, Kavelaars A. Down-regulation of GRK2 after oxygen and glucose deprivation in rat hippocampal slices: role of the PI3-kinase pathway. J Neurochem. 2007 Aug; 102(3):731-40. PMID: 17437535.
      Citations: 8     Fields:    Translation:AnimalsCells
    181. Kleibeuker W, Ledeboer A, Eijkelkamp N, Watkins LR, Maier SF, Zijlstra J, Heijnen CJ, Kavelaars A. A role for G protein-coupled receptor kinase 2 in mechanical allodynia. Eur J Neurosci. 2007 Mar; 25(6):1696-704. PMID: 17408432.
      Citations: 24     Fields:    Translation:Animals
    182. de Kloet CS, Vermetten E, Heijnen CJ, Geuze E, Lentjes EG, Westenberg HG. Enhanced cortisol suppression in response to dexamethasone administration in traumatized veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology. 2007 Apr; 32(3):215-26. PMID: 17296270.
      Citations: 38     Fields:    Translation:HumansCTClinical Trials
    183. Ter Wolbeek M, van Doornen LJ, Coffeng LE, Kavelaars A, Heijnen CJ. Cortisol and severe fatigue: a longitudinal study in adolescent girls. Psychoneuroendocrinology. 2007 Feb; 32(2):171-82. PMID: 17287088.
      Citations: 5     Fields:    Translation:Humans
    184. de Kloet CS, Vermetten E, Bikker A, Meulman E, Geuze E, Kavelaars A, Westenberg HG, Heijnen CJ. Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder. Mol Psychiatry. 2007 May; 12(5):443-53. PMID: 17245326.
      Citations: 28     Fields:    Translation:HumansCells
    185. Vroon A, Lombardi MS, Kavelaars A, Heijnen CJ. Taxol normalizes the impaired agonist-induced beta2-adrenoceptor internalization in splenocytes from GRK2+/- mice. Eur J Pharmacol. 2007 Mar 29; 560(1):9-16. PMID: 17303111.
      Citations: 5     Fields:    Translation:AnimalsCells
    186. Eijkelkamp N, Heijnen CJ, Lucas A, Premont RT, Elsenbruch S, Schedlowski M, Kavelaars A. G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Gut. 2007 Jun; 56(6):847-54. PMID: 17229795.
      Citations: 25     Fields:    Translation:AnimalsCells
    187. Kamphuis PJ, de Vries WB, Bakker JM, Kavelaars A, van Dijk JE, Schipper ME, van Oosterhout MF, Croiset G, Heijnen CJ, van Bel F, Wiegant VM. Reduced life expectancy in rats after neonatal dexamethasone treatment. Pediatr Res. 2007 Jan; 61(1):72-6. PMID: 17211144.
      Citations: 13     Fields:    Translation:Animals
    188. Nijboer CH, Kavelaars A, van Bel F, Heijnen CJ, Groenendaal F. Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat. Dev Neurosci. 2007; 29(4-5):385-92. PMID: 17762206.
      Citations: 16     Fields:    Translation:AnimalsCells
    189. Heijnen CJ. Receptor regulation in neuroendocrine-immune communication: current knowledge and future perspectives. Brain Behav Immun. 2007 Jan; 21(1):1-8. PMID: 17029700.
      Citations: 8     Fields:    Translation:HumansCells
    190. Lucas A, Cobelens PM, Kavelaars A, Heijnen CJ, Holtmann G, Haag S, Gerken G, Langhorst J, Dobos GJ, Schedlowski M, Elsenbruch S. Disturbed in vitro adrenergic modulation of cytokine production in inflammatory bowel diseases in remission. J Neuroimmunol. 2007 Jan; 182(1-2):195-203. PMID: 17112600.
      Citations: 2     Fields:    Translation:HumansCells
    191. Mommersteeg PM, Heijnen CJ, Kavelaars A, van Doornen LJ. Immune and endocrine function in burnout syndrome. Psychosom Med. 2006 Nov-Dec; 68(6):879-86. PMID: 17079708.
      Citations: 16     Fields:    Translation:HumansCells
    192. Karemaker R, Heijnen CJ, Veen S, Baerts W, Samsom J, Visser GH, Kavelaars A, van Doornen LJ, van Bel F. Differences in behavioral outcome and motor development at school age after neonatal treatment for chronic lung disease with dexamethasone versus hydrocortisone. Pediatr Res. 2006 Dec; 60(6):745-50. PMID: 17065571.
      Citations: 21     Fields:    Translation:Humans
    193. Cobelens PM, Kavelaars A, Heijnen CJ, Ribas C, Mayor F, Penela P. Hydrogen peroxide impairs GRK2 translation via a calpain-dependent and cdk1-mediated pathway. Cell Signal. 2007 Feb; 19(2):269-77. PMID: 16963227.
      Citations: 10     Fields:    Translation:AnimalsCells
    194. Elsenbruch S, Lucas A, Holtmann G, Haag S, Gerken G, Riemenschneider N, Langhorst J, Kavelaars A, Heijnen CJ, Schedlowski M. Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndrome. Am J Gastroenterol. 2006 Oct; 101(10):2300-7. PMID: 16952284.
      Citations: 16     Fields:    Translation:Humans
    195. Vroon A, Heijnen CJ, Kavelaars A. GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol. 2006 Dec; 80(6):1214-21. PMID: 16943386.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    196. Krediet TG, Kavelaars A, Vreman HJ, Heijnen CJ, van Bel F. Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants. J Pediatr. 2006 Jun; 148(6):740-6. PMID: 16769379.
      Citations: 10     Fields:    Translation:HumansCells
    197. ter Wolbeek M, van Doornen LJ, Kavelaars A, Heijnen CJ. Severe fatigue in adolescents: a common phenomenon? Pediatrics. 2006 Jun; 117(6):e1078-86. PMID: 16740810.
      Citations: 40     Fields:    Translation:Humans
    198. Nijboer CH, Groenendaal F, Kavelaars A, Hagberg HH, van Bel F, Heijnen CJ. Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway. J Cereb Blood Flow Metab. 2007 Feb; 27(2):282-92. PMID: 16736041.
      Citations: 48     Fields:    Translation:AnimalsCells
    199. Mommersteeg PM, Heijnen CJ, Verbraak MJ, van Doornen LJ. A longitudinal study on cortisol and complaint reduction in burnout. Psychoneuroendocrinology. 2006 Aug; 31(7):793-804. PMID: 16698185.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    200. van den Tweel ER, Kavelaars A, Lombardi MS, Nijboer CH, Groenendaal F, van Bel F, Heijnen CJ. Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage. Pediatr Res. 2006 Mar; 59(3):434-9. PMID: 16492985.
      Citations: 20     Fields:    Translation:Animals
    201. Mommersteeg PM, Keijsers GP, Heijnen CJ, Verbraak MJ, van Doornen LJ. Cortisol deviations in people with burnout before and after psychotherapy: a pilot study. Health Psychol. 2006 Mar; 25(2):243-8. PMID: 16569117.
      Citations: 15     Fields:    Translation:Humans
    202. Kavelaars A, Heijnen CJ. Stress, genetics, and immunity. Brain Behav Immun. 2006 Jul; 20(4):313-6. PMID: 16495034.
      Citations: 1     Fields:    Translation:HumansAnimals
    203. van den Tweel ER, Kavelaars A, Lombardi MS, Groenendaal F, May M, Heijnen CJ, van Bel F. Selective inhibition of nuclear factor-kappaB activation after hypoxia/ischemia in neonatal rats is not neuroprotective. Pediatr Res. 2006 Feb; 59(2):232-6. PMID: 16439584.
      Citations: 9     Fields:    Translation:AnimalsCells
    204. Vreugdenhil HA, Lachmann B, Haitsma JJ, Zijlstra J, Heijnen CJ, Jansen NJ, van Vught AJ. Exogenous surfactant restores lung function but not peripheral immunosuppression in ventilated surfactant-deficient rats. Exp Lung Res. 2006 Jan-Feb; 32(1-2):1-14. PMID: 16809217.
      Citations: 3     Fields:    Translation:AnimalsCells
    205. Lucas A, Holtmann G, Gerken G, Pietsch A, Braun-Lang U, Gilani K, Strassburger K, Gesing S, Janssen OE, Kavelaars A, Heijnen CJ, Schedlowski M, Elsenbruch S. Visceral pain and public speaking stress: neuroendocrine and immune cell responses in healthy subjects. Brain Behav Immun. 2006 Jan; 20(1):49-56. PMID: 16364816.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    206. Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg HG. Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder. Psychoneuroendocrinology. 2006 Apr; 31(3):355-60. PMID: 16249058.
      Citations: 3     Fields:    Translation:HumansCells
    207. Jiménez-Sainz MC, Murga C, Kavelaars A, Jurado-Pueyo M, Krakstad BF, Heijnen CJ, Mayor F, Aragay AM. G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits. Mol Biol Cell. 2006 Jan; 17(1):25-31. PMID: 16221891.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    208. de Kloet CS, Vermetten E, Geuze E, Kavelaars A, Heijnen CJ, Westenberg HG. Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res. 2006 Sep; 40(6):550-67. PMID: 16214171.
      Citations: 147     Fields:    Translation:Humans
    209. van den Tweel ER, Nijboer C, Kavelaars A, Heijnen CJ, Groenendaal F, van Bel F. Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain. J Neuroimmunol. 2005 Oct; 167(1-2):64-71. PMID: 16112751.
      Citations: 18     Fields:    Translation:Animals
    210. Mommersteeg PM, Heijnen CJ, Verbraak MJ, van Doornen LJ. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology. 2006 Feb; 31(2):216-25. PMID: 16150550.
      Citations: 21     Fields:    Translation:Humans
    211. Dulos J, Kaptein A, Kavelaars A, Heijnen C, Boots A. Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b. Arthritis Res Ther. 2005; 7(6):R1271-80. PMID: 16277680.
      Citations: 7     Fields:    Translation:HumansCells
    212. Heijnen CJ. Stress relief by oxygen? Brain Behav Immun. 2005 May; 19(3):201-2. PMID: 15797307.
      Citations:    Fields:    Translation:HumansAnimals
    213. Vroon A, Kavelaars A, Limmroth V, Lombardi MS, Goebel MU, Van Dam AM, Caron MG, Schedlowski M, Heijnen CJ. G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Immunol. 2005 Apr 01; 174(7):4400-6. PMID: 15778405.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    214. Kavelaars A, Cobelens PM, Teunis MA, Heijnen CJ. Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene. J Neuroimmunol. 2005 Apr; 161(1-2):162-8. PMID: 15748955.
      Citations: 16     Fields:    Translation:AnimalsCells
    215. Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 2005 Mar; 52(3):770-8. PMID: 15751070.
      Citations: 18     Fields:    Translation:HumansCells
    216. van den Tweel ER, van Bel F, Kavelaars A, Peeters-Scholte CM, Haumann J, Nijboer CH, Heijnen CJ, Groenendaal F. Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats. J Cereb Blood Flow Metab. 2005 Jan; 25(1):67-74. PMID: 15678113.
      Citations: 15     Fields:    Translation:AnimalsCells
    217. Avitsur R, Kavelaars A, Heijnen C, Sheridan JF. Social stress and the regulation of tumor necrosis factor-alpha secretion. Brain Behav Immun. 2005 Jul; 19(4):311-7. PMID: 15944070.
      Citations: 52     Fields:    Translation:AnimalsCells
    218. Sajti E, Kavelaars A, van Meeteren N, Teunis M, Gispen WH, Heijnen C. Tumor angiogenesis and metastasis formation are associated with individual differences in behavior of inbred Lewis rats. Brain Behav Immun. 2004 Nov; 18(6):497-504. PMID: 15331120.
      Citations:    Fields:    Translation:AnimalsCells
    219. Sajti E, van Meeteren N, Kavelaars A, van der Net J, Gispen WH, Heijnen C. Individual differences in behavior of inbred Lewis rats are associated with severity of joint destruction in adjuvant-induced arthritis. Brain Behav Immun. 2004 Nov; 18(6):505-14. PMID: 15331121.
      Citations: 5     Fields:    Translation:Animals
    220. Teunis MA, Heijnen CJ, Cools AR, Kavelaars A. Reduced splenic natural killer cell activity in rats with a hyperreactive dopaminergic system. Psychoneuroendocrinology. 2004 Sep; 29(8):1058-64. PMID: 15219657.
      Citations: 7     Fields:    Translation:AnimalsCells
    221. Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg H. Decreased TNF-alpha and NK activity in obsessive-compulsive disorder. Psychoneuroendocrinology. 2004 Aug; 29(7):945-52. PMID: 15177711.
      Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
    222. Plötz FB, Slutsky AS, van Vught AJ, Heijnen CJ. Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med. 2004 Oct; 30(10):1865-72. PMID: 15221129.
      Citations: 65     Fields:    Translation:HumansAnimals
    223. Eijkelkamp N, Cobelens PM, Sanders VM, Heijnen CJ, Kavelaars A. Tissue specific effects of the beta 2-adrenergic agonist salbutamol on LPS-induced IFN-gamma, IL-10 and TGF-beta responses in vivo. J Neuroimmunol. 2004 May; 150(1-2):3-9. PMID: 15081243.
      Citations: 3     Fields:    Translation:Animals
    224. Lombardi MS, van den Tweel E, Kavelaars A, Groenendaal F, van Bel F, Heijnen CJ. Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain. Stroke. 2004 Apr; 35(4):981-6. PMID: 15017017.
      Citations: 16     Fields:    Translation:Animals
    225. Vroon A, Heijnen CJ, Lombardi MS, Cobelens PM, Mayor F, Caron MG, Kavelaars A. Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. J Leukoc Biol. 2004 May; 75(5):901-9. PMID: 14761932.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    226. Vroon A, Heijnen CJ, Raatgever R, Touw IP, Ploemacher RE, Premont RT, Kavelaars A. GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. J Leukoc Biol. 2004 Apr; 75(4):698-704. PMID: 14704365.
      Citations: 46     Fields:    Translation:AnimalsCells
    227. Vreugdenhil HA, Heijnen CJ, Plötz FB, Zijlstra J, Jansen NJ, Haitsma JJ, Lachmann B, van Vught AJ. Mechanical ventilation of healthy rats suppresses peripheral immune function. Eur Respir J. 2004 Jan; 23(1):122-8. PMID: 14738243.
      Citations: 15     Fields:    Translation:AnimalsCells
    228. Haerter K, Vroon A, Kavelaars A, Heijnen CJ, Limmroth V, Espinosa E, Schedlowski M, Elsenbruch S. In vitro adrenergic modulation of cellular immune functions in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2004 Jan; 146(1-2):126-32. PMID: 14698854.
      Citations: 5     Fields:    Translation:Animals
    229. Kavelaars A, Vroon A, Raatgever RP, Fong AM, Premont RT, Patel DD, Lefkowitz RJ, Heijnen CJ. Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. J Immunol. 2003 Dec 01; 171(11):6128-34. PMID: 14634128.
      Citations: 30     Fields:    Translation:AnimalsCells
    230. Peters ML, Godaert GL, Ballieux RE, Heijnen CJ. Moderation of physiological stress responses by personality traits and daily hassles: less flexibility of immune system responses. Biol Psychol. 2003 Dec; 65(1):21-48. PMID: 14638287.
      Citations: 8     Fields:    Translation:Humans
    231. van der Heide-Jalving M, Kamphuis PJ, van der Laan MJ, Bakker JM, Wiegant VM, Heijnen CJ, Veen S, van Bel F. Short- and long-term effects of neonatal glucocorticoid therapy: is hydrocortisone an alternative to dexamethasone? Acta Paediatr. 2003 Jul; 92(7):827-35. PMID: 12892163.
      Citations: 19     Fields:    Translation:Humans
    232. Plötz FB, Vreugdenhil HA, van Vught AJ, Heijnen CJ. Mechanical ventilation and multiple organ failure. Lancet. 2003 May 10; 361(9369):1654. PMID: 12747909.
      Citations: 1     Fields:    Translation:HumansAnimals
    233. Vreugdenhil HA, Haitsma JJ, Jansen KJ, Zijlstra J, Plötz FB, van Dijk JE, Lachmann B, van Vught H, Heijnen CJ. Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation. Intensive Care Med. 2003 Jun; 29(6):915-922. PMID: 12734649.
      Citations: 9     Fields:    Translation:AnimalsCells
    234. Pawlak CR, Witte T, Heiken H, Hundt M, Schubert J, Wiese B, Bischoff-Renken A, Gerber K, Licht B, Goebel MU, Heijnen CJ, Schmidt RE, Schedlowski M. Flares in patients with systemic lupus erythematosus are associated with daily psychological stress. Psychother Psychosom. 2003 May-Jun; 72(3):159-65. PMID: 12707483.
      Citations: 7     Fields:    Translation:Humans
    235. Vroon A, Lombardi MS, Kavelaars A, Heijnen CJ. Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis. J Neuroimmunol. 2003 Apr; 137(1-2):79-86. PMID: 12667650.
      Citations: 16     Fields:    Translation:Animals
    236. Teunis MA, Heijnen CJ, Sluyter F, Bakker JM, Van Dam AM, Hof M, Cools AR, Kavelaars A. Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age. J Neuroimmunol. 2002 Dec; 133(1-2):30-8. PMID: 12446005.
      Citations: 14     Fields:    Translation:AnimalsCells
    237. Van Eden W, Van Der Zee R, Van Kooten P, Berlo SE, Cobelens PM, Kavelaars A, Heijnen CJ, Prakken B, Roord S, Albani S. Balancing the immune system: Th1 and Th2. Ann Rheum Dis. 2002 Nov; 61 Suppl 2:ii25-8. PMID: 12379616.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    238. Cobelens PM, Kavelaars A, Vroon A, Ringeling M, van der Zee R, van Eden W, Heijnen CJ. The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity. J Immunol. 2002 Nov 01; 169(9):5028-35. PMID: 12391218.
      Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    239. Denys D, Kavelaars A, Heijnen CJ, Westenberg H. A case of venlafaxine-induced inhibition of T-lymphocyte proliferation. Psychopharmacology (Berl). 2002 Dec; 164(4):432. PMID: 12457275.
      Citations: 1     Fields:    Translation:HumansCells
    240. Kittner JM, Jacobs R, Pawlak CR, Heijnen CJ, Schedlowski M, Schmidt RE. Adrenaline-induced immunological changes are altered in patients with rheumatoid arthritis. Rheumatology (Oxford). 2002 Sep; 41(9):1031-9. PMID: 12209038.
      Citations: 6     Fields:    Translation:HumansCells
    241. Myrianthefs P, Baltopoulos G, Batistaki C, Venetsanou K, Koutsopoulou E, Evagelpolou P, Boutzouka E. Mechanical ventilation and the immune response. Intensive Care Med. 2002 Sep; 28(9):1365-6; author reply 1367. PMID: 12400583.
      Citations:    Fields:    Translation:Humans
    242. Bont L, Versteegh J, Swelsen WT, Heijnen CJ, Kavelaars A, Brus F, Draaisma JM, Pekelharing-Berghuis M, van Diemen-Steenvoorde RA, Kimpen JL. Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity. Pediatr Res. 2002 Sep; 52(3):363-7. PMID: 12193668.
      Citations: 46     Fields:    Translation:HumansCells
    243. Straub RH, Kittner JM, Heijnen C, Schedlowski M, Schmidt RE, Jacobs R. Infusion of epinephrine decreases serum levels of cortisol and 17-hydroxyprogesterone in patients with rheumatoid arthritis. J Rheumatol. 2002 Aug; 29(8):1659-64. PMID: 12180725.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    244. Lombardi MS, Kavelaars A, Penela P, Scholtens EJ, Roccio M, Schmidt RE, Schedlowski M, Mayor F, Heijnen CJ. Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism. Mol Pharmacol. 2002 Aug; 62(2):379-88. PMID: 12130691.
      Citations: 16     Fields:    Translation:HumansCells
    245. Cobelens PM, Kavelaars A, van der Zee R, van Eden W, Heijnen CJ. Dynamics of mycobacterial HSP65-induced T-cell cytokine expression during oral tolerance induction in adjuvant arthritis. Rheumatology (Oxford). 2002 Jul; 41(7):775-9. PMID: 12096227.
      Citations: 5     Fields:    Translation:AnimalsCells
    246. Teunis MA, Kavelaars A, Voest E, Bakker JM, Ellenbroek BA, Cools AR, Heijnen CJ. Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system. FASEB J. 2002 Sep; 16(11):1465-7. PMID: 12205050.
      Citations: 21     Fields:    Translation:Animals
    247. Heijnen CJ, Rouppe van der Voort C, van de Pol M, Kavelaars A. Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells. J Neuroimmunol. 2002 Apr; 125(1-2):66-72. PMID: 11960642.
      Citations: 18     Fields:    Translation:HumansCells
    248. Plötz FB, Vreugdenhil HA, Slutsky AS, Zijlstra J, Heijnen CJ, van Vught H. Mechanical ventilation alters the immune response in children without lung pathology. Intensive Care Med. 2002 Apr; 28(4):486-92. PMID: 11967605.
      Citations: 21     Fields:    Translation:HumansCells
    249. van den Tweel ER, Peeters-Scholte CM, van Bel F, Heijnen CJ, Groenendaal F. Inhibition of nNOS and iNOS following hypoxia-ischaemia improves long-term outcome but does not influence the inflammatory response in the neonatal rat brain. Dev Neurosci. 2002; 24(5):389-95. PMID: 12640177.
      Citations: 11     Fields:    Translation:Animals
    250. Peeters-Scholte C, Koster J, van den Tweel E, Blomgren K, Hamers N, Zhu C, van Buul-Offers S, Hagberg H, van Bel F, Heijnen C, Groenendaal F. Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia. Dev Neurosci. 2002; 24(5):396-404. PMID: 12640178.
      Citations: 5     Fields:    Translation:AnimalsCells
    251. Lombardi MS, Kavelaars A, Heijnen CJ. Role and modulation of G protein-coupled receptor signaling in inflammatory processes. Crit Rev Immunol. 2002; 22(2):141-63. PMID: 12433131.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    252. Rook GA, Lightman SL, Heijnen CJ. Can nerve damage disrupt neuroendocrine immune homeostasis? Leprosy as a case in point. Trends Immunol. 2002 Jan; 23(1):18-22. PMID: 11801450.
      Citations: 2     Fields:    Translation:HumansCells
    253. Bakker JM, van Bel F, Heijnen CJ. Neonatal glucocorticoids and the developing brain: short-term treatment with life-long consequences? Trends Neurosci. 2001 Nov; 24(11):649-53. PMID: 11672809.
      Citations: 15     Fields:    Translation:HumansAnimals
    254. van der Pompe G, Antoni MH, Duivenvoorden HJ, de Graeff A, Simonis RF, van der Vegt SG, Heijnen CJ. An exploratory study into the effect of group psychotherapy on cardiovascular and immunoreactivity to acute stress in breast cancer patients. Psychother Psychosom. 2001 Nov-Dec; 70(6):307-18. PMID: 11598430.
      Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
    255. Jacobs R, Pawlak CR, Mikeska E, Meyer-Olson D, Martin M, Heijnen CJ, Schedlowski M, Schmidt RE. Systemic lupus erythematosus and rheumatoid arthritis patients differ from healthy controls in their cytokine pattern after stress exposure. Rheumatology (Oxford). 2001 Aug; 40(8):868-75. PMID: 11511755.
      Citations: 14     Fields:    Translation:HumansCells
    256. van der Pompe G, Bernards N, Kavelaars A, Heijnen C. An exploratory study into the effect of exhausting bicycle exercise on endocrine and immune responses in post-menopausal women: relationships between vigour and plasma cortisol concentrations and lymphocyte proliferation following exercise. Int J Sports Med. 2001 Aug; 22(6):447-53. PMID: 11531039.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    257. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JM, Pekelharing-Berghuis M, van Diemen-Steenvoorde RA, Kimpen JL. Local interferon-gamma levels during respiratory syncytial virus lower respiratory tract infection are associated with disease severity. J Infect Dis. 2001 Aug 01; 184(3):355-8. PMID: 11443563.
      Citations: 43     Fields:    Translation:Humans
    258. van Middendorp H, Geenen R, Kuis W, Heijnen CJ, Sinnema G. Psychological adjustment of adolescent girls with chronic fatigue syndrome. Pediatrics. 2001 Mar; 107(3):E35. PMID: 11230616.
      Citations: 5     Fields:    Translation:Humans
    259. Lombardi MS, Kavelaars A, Cobelens PM, Schmidt RE, Schedlowski M, Heijnen CJ. Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system. J Immunol. 2001 Feb 01; 166(3):1635-40. PMID: 11160205.
      Citations: 45     Fields:    Translation:AnimalsCells
    260. Bakker JM, Kavelaars A, Kamphuis PJ, Zijlstra J, van Bel F, Heijnen CJ. Neonatal dexamethasone treatment induces long-lasting changes in T-cell receptor vbeta repertoire in rats. J Neuroimmunol. 2001 Jan 01; 112(1-2):47-54. PMID: 11108932.
      Citations: 4     Fields:    Translation:AnimalsCells
    261. Cobelens PM, Heijnen CJ, Nieuwenhuis EE, Kramer PP, van der Zee R, van Eden W, Kavelaars A. Treatment of adjuvant-induced arthritis by oral administration of mycobacterial Hsp65 during disease. Arthritis Rheum. 2000 Dec; 43(12):2694-702. PMID: 11145027.
      Citations: 10     Fields:    Translation:AnimalsCells
    262. Bakker JM, Kavelaars A, Kamphuis PJ, Cobelens PM, van Vugt HH, van Bel F, Heijnen CJ. Neonatal dexamethasone treatment increases susceptibility to experimental autoimmune disease in adult rats. J Immunol. 2000 Nov 15; 165(10):5932-7. PMID: 11067955.
      Citations: 11     Fields:    Translation:AnimalsCells
    263. Nieuwenhuis EE, Visser MR, Kavelaars A, Cobelens PM, Fleer A, Harmsen W, Verhoef J, Akkermans LM, Heijnen CJ. Oral antibiotics as a novel therapy for arthritis: evidence for a beneficial effect of intestinal Escherichia coli. Arthritis Rheum. 2000 Nov; 43(11):2583-9. PMID: 11083284.
      Citations: 11     Fields:    Translation:AnimalsCells
    264. Chikanza IC, Kuis W, Heijnen CJ. The influence of the hormonal system on pediatric rheumatic diseases. Rheum Dis Clin North Am. 2000 Nov; 26(4):911-25. PMID: 11084951.
      Citations: 6     Fields:    Translation:Humans
    265. Roupe van der Voort C, Heijnen CJ, Wulffraat N, Kuis W, Kavelaars A. Stress induces increases in IL-6 production by leucocytes of patients with the chronic inflammatory disease juvenile rheumatoid arthritis: a putative role for alpha(1)-adrenergic receptors. J Neuroimmunol. 2000 Oct 02; 110(1-2):223-9. PMID: 11024553.
      Citations: 23     Fields:    Translation:HumansCells
    266. Knook L, Kavelaars A, Sinnema G, Kuis W, Heijnen CJ. High nocturnal melatonin in adolescents with chronic fatigue syndrome. J Clin Endocrinol Metab. 2000 Oct; 85(10):3690-2. PMID: 11061525.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    267. Rouppe van der Voort C, Kavelaars A, van de Pol M, Heijnen CJ. Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors. J Neuroimmunol. 2000 Aug 01; 108(1-2):82-91. PMID: 10900341.
      Citations: 15     Fields:    Translation:HumansCells
    268. Bont L, Kavelaars A, Heijnen CJ, van Vught AJ, Kimpen JL. Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis. J Infect Dis. 2000 May; 181(5):1772-5. PMID: 10823782.
      Citations: 14     Fields:    Translation:Humans
    269. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JT, Geelen SM, Kimpen JL. Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study. Am J Respir Crit Care Med. 2000 May; 161(5):1518-23. PMID: 10806148.
      Citations: 37     Fields:    Translation:HumansCells
    270. Heijnen CJ. Who believes in "communication"? The Norman Cousins Lecture, 1999. Brain Behav Immun. 2000 Mar; 14(1):2-9. PMID: 10729213.
      Citations:    Fields:    Translation:HumansAnimalsCells
    271. Kavelaars A, Kuis W, Knook L, Sinnema G, Heijnen CJ. Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome. J Clin Endocrinol Metab. 2000 Feb; 85(2):692-6. PMID: 10690878.
      Citations: 20     Fields:    Translation:HumansCells
    272. Kavelaars A, Heijnen CJ. Expression of preproenkephalin mRNA and production and secretion of enkephalins by human thymocytes. Ann N Y Acad Sci. 2000; 917:778-83. PMID: 11268407.
      Citations: 2     Fields:    Translation:HumansCells
    273. Pawlak CR, Jacobs R, Mikeska E, Ochsmann S, Lombardi MS, Kavelaars A, Heijnen CJ, Schmidt RE, Schedlowski M. Patients with systemic lupus erythematosus differ from healthy controls in their immunological response to acute psychological stress. Brain Behav Immun. 1999 Dec; 13(4):287-302. PMID: 10600217.
      Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
    274. Kavelaars A, Heijnen CJ, Tennekes R, Bruggink JE, Koolhaas JM. Individual behavioral characteristics of wild-type rats predict susceptibility to experimental autoimmune encephalomyelitis. Brain Behav Immun. 1999 Dec; 13(4):279-86. PMID: 10600216.
      Citations: 9     Fields:    Translation:Animals
    275. Heijnen CJ, Kavelaars A. The importance of being receptive. J Neuroimmunol. 1999 Dec; 100(1-2):197-202. PMID: 10695730.
      Citations: 2     Fields:    Translation:HumansCells
    276. Heijnen CJ, Cohen N. Clinical significance of the neuroendocrine control of autoimmune processes: a important niche for psychoneuroimmunologists? Brain Behav Immun. 1999 Dec; 13(4):267-70. PMID: 10600214.
      Citations: 1     Fields:    Translation:HumansAnimals
    277. Kavelaars A, van Der Voort CR, Heijnen CJ. Adrenergic receptor subtypes in human peripheral blood lymphocytes. Hypertension. 1999 Nov; 34(5):e5. PMID: 10567203.
      Citations: 1     Fields:    Translation:HumansCells
    278. Bont L, Heijnen CJ, Kavelaars A, van Aalderen WM, Brus F, Draaisma JT, Geelen SM, van Vught HJ, Kimpen JL. Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis. Eur Respir J. 1999 Jul; 14(1):144-9. PMID: 10489842.
      Citations: 38     Fields:    Translation:HumansCellsCTClinical Trials
    279. Peters ML, Godaert GL, Ballieux RE, Brosschot JF, Sweep FC, Swinkels LM, van Vliet M, Heijnen CJ. Immune responses to experimental stress: effects of mental effort and uncontrollability. Psychosom Med. 1999 Jul-Aug; 61(4):513-24. PMID: 10443760.
      Citations: 9     Fields:    Translation:HumansCells
    280. Duval EL, Kavelaars A, Veenhuizen L, van Vught AJ, van de Wal HJ, Heijnen CJ. Pro- and anti-inflammatory cytokine patterns during and after cardiac surgery in young children. Eur J Pediatr. 1999 May; 158(5):387-93. PMID: 10333121.
      Citations: 11     Fields:    Translation:HumansCells
    281. Lombardi MS, Kavelaars A, Schedlowski M, Bijlsma JW, Okihara KL, Van de Pol M, Ochsmann S, Pawlak C, Schmidt RE, Heijnen CJ. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J. 1999 Apr; 13(6):715-25. PMID: 10094932.
      Citations: 63     Fields:    Translation:HumansCells
    282. Rouppe van der Voort C, Kavelaars A, van de Pol M, Heijnen CJ. Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes. J Neuroimmunol. 1999 Mar 01; 95(1-2):165-73. PMID: 10229127.
      Citations: 16     Fields:    Translation:HumansCells
    283. Kavelaars A, van der Pompe G, Bakker JM, van Hasselt PM, Cats B, Visser GH, Heijnen CJ. Altered immune function in human newborns after prenatal administration of betamethasone: enhanced natural killer cell activity and decreased T cell proliferation in cord blood. Pediatr Res. 1999 Mar; 45(3):306-12. PMID: 10088646.
      Citations: 20     Fields:    Translation:HumansCells
    284. Plötz FB, van Vught H, Heijnen CJ. Ventilator-induced lung inflammation: is it always harmful? Intensive Care Med. 1999 Feb; 25(2):236. PMID: 10193557.
      Citations: 2     Fields:    Translation:Humans
    285. van der Pompe G, Bernards N, Meijman TF, Heijnen CJ. The effect of depressive symptomatology on plasma cortisol responses to acute bicycle exercise among post-menopausal women. Psychiatry Res. 1999 Jan 18; 85(1):113-7. PMID: 10195322.
      Citations: 3     Fields:    Translation:Humans
    286. Geenen R, Godaert GL, Heijnen CJ, Vianen ME, Wenting MJ, Nederhoff MG, Bijlsma JW. Experimentally induced stress in rheumatoid arthritis of recent onset: effects on peripheral blood lymphocytes. Clin Exp Rheumatol. 1998 Sep-Oct; 16(5):553-9. PMID: 9779302.
      Citations: 3     Fields:    Translation:HumansCells
    287. Kuis W, Heijnen CJ, Sinnema G, Kavelaars A, van der Net J, Helders PJ. Pain in childhood rheumatic arthritis. Baillieres Clin Rheumatol. 1998 May; 12(2):229-44. PMID: 9890096.
      Citations: 1     Fields:    Translation:Humans
    288. Brosschot JF, Godaert GL, Benschop RJ, Olff M, Ballieux RE, Heijnen CJ. Experimental stress and immunological reactivity: a closer look at perceived uncontrollability. Psychosom Med. 1998 May-Jun; 60(3):359-61. PMID: 9625225.
      Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
    289. Benschop RJ, Geenen R, Mills PJ, Naliboff BD, Kiecolt-Glaser JK, Herbert TB, van der Pompe G, Miller GE, Matthews KA, Godaert GL, Gilmore SL, Glaser R, Heijnen CJ, Dopp JM, Bijlsma JW, Solomon GF, Cacioppo JT. Cardiovascular and immune responses to acute psychological stress in young and old women: a meta-analysis. Psychosom Med. 1998 May-Jun; 60(3):290-6. PMID: 9625216.
      Citations: 13     Fields:    Translation:HumansCells
    290. van der Pompe G, Antoni MH, Visser A, Heijnen CJ. Effect of mild acute stress on immune cell distribution and natural killer cell activity in breast cancer patients. Biol Psychol. 1998 May; 48(1):21-35. PMID: 9676357.
      Citations: 3     Fields:    Translation:HumansCells
    291. Kavelaars A, de Jong-de Vos van Steenwijk T, Kuis W, Heijnen CJ. The reactivity of the cardiovascular system and immunomodulation by catecholamines in juvenile chronic arthritis. Ann N Y Acad Sci. 1998 May 01; 840:698-704. PMID: 9629296.
      Citations: 5     Fields:    Translation:HumansAnimals
    292. Kamphuis S, Eriksson F, Kavelaars A, Zijlstra J, van de Pol M, Kuis W, Heijnen CJ. Role of endogenous pro-enkephalin A-derived peptides in human T cell proliferation and monocyte IL-6 production. J Neuroimmunol. 1998 Apr 01; 84(1):53-60. PMID: 9600708.
      Citations: 9     Fields:    Translation:HumansCells
    293. Bakker JM, van den Dobbelsteen GPJM, Kroes H, Kavelaars A, Heijnen CJ, Tilders FJH, van Rees EP. Long-term gender-specific effects of manipulation during pregnancy on immune and endocrine responsiveness in rat offspring. J Neuroimmunol. 1998 Feb; 82(1):56-63. PMID: 9526846.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    294. Peters ML, Godaert GL, Ballieux RE, van Vliet M, Willemsen JJ, Sweep FC, Heijnen CJ. Cardiovascular and endocrine responses to experimental stress: effects of mental effort and controllability. Psychoneuroendocrinology. 1998 Jan; 23(1):1-17. PMID: 9618748.
      Citations: 38     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    295. Kuis W, Heijnen CJ, Hogeweg JA, Sinnema G, Helders PJ. How painful is juvenile chronic arthritis? Arch Dis Child. 1997 Nov; 77(5):451-3. PMID: 9487974.
      Citations: 4     Fields:    Translation:Humans
    296. Kuis W, Kavelaars A, Prakken BJ, Wulffraat NM, Heijnen CJ. Dialogue between the brain and the immune system in juvenile chronic arthritis. Rev Rhum Engl Ed. 1997 Oct 15; 64(10 Suppl):146S-148S. PMID: 9385665.
      Citations: 1     Fields:    Translation:Humans
    297. Kamphuis S, Kavelaars A, Brooimans R, Kuis W, Zegers BJ, Heijnen CJ. T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells. J Neuroimmunol. 1997 Oct; 79(1):91-9. PMID: 9357452.
      Citations: 8     Fields:    Translation:HumansCells
    298. Kavelaars A, van de Pol M, Zijlstra J, Heijnen CJ. Beta 2-adrenergic activation enhances interleukin-8 production by human monocytes. J Neuroimmunol. 1997 Aug; 77(2):211-6. PMID: 9258252.
      Citations: 27     Fields:    Translation:HumansCells
    299. van der Pompe G, Duivenvoorden HJ, Antoni MH, Visser A, Heijnen CJ. Effectiveness of a short-term group psychotherapy program on endocrine and immune function in breast cancer patients: an exploratory study. J Psychosom Res. 1997 May; 42(5):453-66. PMID: 9194018.
      Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
    300. Bakker JM, Schmidt ED, Kroes H, Kavelaars A, Heijnen CJ, Tilders FJ, van Rees EP. Effects of neonatal dexamethasone treatment on hypothalamo-pituitary adrenal axis and immune system of the rat. J Neuroimmunol. 1997 Apr; 74(1-2):69-76. PMID: 9119981.
      Citations: 7     Fields:    Translation:AnimalsCells
    301. Kavelaars A, Heijnen CJ, Ellenbroek B, van Loveren H, Cools A. Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their susceptibility to inflammatory and infectious diseases: a study on rats with group-specific differences in structure and reactivity of hypothalamic-pituitary-adrenal axis. J Neurosci. 1997 Apr 01; 17(7):2580-4. PMID: 9065517.
      Citations: 7     Fields:    Translation:AnimalsCells
    302. van Gent T, Heijnen CJ, Treffers PD. Autism and the immune system. J Child Psychol Psychiatry. 1997 Mar; 38(3):337-49. PMID: 9232480.
      Citations: 27     Fields:    Translation:HumansCells
    303. van der Pompe G, Antoni MH, Duievenvoorden HJ, Heijnen CJ. Relations of plasma ACTH and cortisol levels with the distribution and function of peripheral blood cells in response to a behavioral challenge in breast cancer: an empirical exploration by means of statistical modeling. Int J Behav Med. 1997; 4(2):145-69. PMID: 16250736.
      Citations: 2     Fields:    
    304. Kuis W, de Jong-de Vos van Steenwijk C, Sinnema G, Kavelaars A, Prakken B, Helders PJ, Heijnen CJ. The autonomic nervous system and the immune system in juvenile rheumatoid arthritis. Brain Behav Immun. 1996 Dec; 10(4):387-98. PMID: 9045753.
      Citations: 20     Fields:    Translation:HumansCells
    305. Heijnen CJ, Rouppe van der Voort C, Wulffraat N, van der Net J, Kuis W, Kavelaars A. Functional alpha 1-adrenergic receptors on leukocytes of patients with polyarticular juvenile rheumatoid arthritis. J Neuroimmunol. 1996 Dec; 71(1-2):223-6. PMID: 8982123.
      Citations: 32     Fields:    Translation:HumansCells
    306. Kavelaars A, Cats B, Visser GH, Zegers BJ, Bakker JM, van Rees EP, Heunen CJ. Ontogency of the responses of human peripheral blood T cells to glucocorticoids. Brain Behav Immun. 1996 Sep; 10(3):288-97. PMID: 8954600.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    307. Gerritsen W, Heijnen CJ, Wiegant VM, Bermond B, Frijda NH. Experimental social fear: immunological, hormonal, and autonomic concomitants. Psychosom Med. 1996 May-Jun; 58(3):273-86. PMID: 8771627.
      Citations: 4     Fields:    Translation:HumansCells
    308. van der Pompe G, Antoni MH, Heijnen CJ. Elevated basal cortisol levels and attenuated ACTH and cortisol responses to a behavioral challenge in women with metastatic breast cancer. Psychoneuroendocrinology. 1996 May; 21(4):361-74. PMID: 8844875.
      Citations: 23     Fields:    Translation:HumansCTClinical Trials
    309. Bakker JM, Schmidt ED, Kroes H, Kavelaars A, Heijnen CJ, Tilders FJ, van Rees EP. Effects of short-term dexamethasone treatment during pregnancy on the development of the immune system and the hypothalamo-pituitary adrenal axis in the rat. J Neuroimmunol. 1995 Dec 31; 63(2):183-91. PMID: 8550816.
      Citations: 11     Fields:    Translation:AnimalsCells
    310. Kok FW, Heijnen CJ, Bruijn JA, Westenberg HG, van Ree JM. Immunoglobulin production in vitro in major depression: a pilot study on the modulating action of endogenous cortisol. Biol Psychiatry. 1995 Aug 15; 38(4):217-26. PMID: 8547443.
      Citations: 1     Fields:    Translation:HumansCells
    311. Kavelaars A, Zijlstra J, Bakker JM, Van Rees EP, Visser GH, Zegers BJ, Heijnen CJ. Increased dexamethasone sensitivity of neonatal leukocytes: different mechanisms of glucocorticoid inhibition of T cell proliferation in adult and neonatal cells. Eur J Immunol. 1995 May; 25(5):1346-51. PMID: 7774638.
      Citations: 4     Fields:    Translation:HumansCells
    312. Benschop RJ, Godaert GL, Geenen R, Brosschot JF, De Smet MB, Olff M, Heijnen CJ, Ballieux RE. Relationships between cardiovascular and immunological changes in an experimental stress model. Psychol Med. 1995 Mar; 25(2):323-7. PMID: 7675920.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    313. Hogeweg JA, de Kruyff I, Heijnen CJ, Helders PJ, Kuis W. [The effect of the nervous system on joint inflammations]. Ned Tijdschr Geneeskd. 1995 Jan 07; 139(1):11-4. PMID: 7530339.
      Citations:    Fields:    Translation:HumansCells
    314. Olff M, Brosschot JF, Godaert G, Benschop RJ, Ballieux RE, Heijnen CJ, de Smet MB, Ursin H. Modulatory effects of defense and coping on stress-induced changes in endocrine and immune parameters. Int J Behav Med. 1995; 2(2):85-103. PMID: 16250779.
      Citations: 4     Fields:    
    315. Benschop RJ, Nijkamp FP, Ballieux RE, Heijnen CJ. The effects of beta-adrenoceptor stimulation on adhesion of human natural killer cells to cultured endothelium. Br J Pharmacol. 1994 Dec; 113(4):1311-6. PMID: 7889286.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    316. Kavelaars A, Broeke D, Jeurissen F, Kardux J, Meijer A, Franklin R, Gelfand EW, Heijnen CJ. Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production. J Immunol. 1994 Oct 15; 153(8):3691-9. PMID: 7930588.
      Citations: 11     Fields:    Translation:HumansCells
    317. Kuis W, Heijnen CJ. Rheumatoid arthritis and juvenile chronic arthritis: the role of the neuro-endocrine system. Clin Exp Rheumatol. 1994 Sep-Oct; 12 Suppl 10:S29-34. PMID: 7525132.
      Citations: 1     Fields:    Translation:HumansAnimals
    318. Kavelaars A, Jeurissen F, Heijnen CJ. Substance P receptors and signal transduction in leukocytes. Immunomethods. 1994 Aug; 5(1):41-8. PMID: 7531101.
      Citations: 4     Fields:    Translation:HumansCells
    319. Brosschot JF, Benschop RJ, Godaert GL, Olff M, De Smet M, Heijnen CJ, Ballieux RE. Influence of life stress on immunological reactivity to mild psychological stress. Psychosom Med. 1994 May-Jun; 56(3):216-24. PMID: 8084967.
      Citations: 18     Fields:    Translation:Humans
    320. Jeurissen F, Kavelaars A, Korstjens M, Broeke D, Franklin RA, Gelfand EW, Heijnen CJ. Monocytes express a non-neurokinin substance P receptor that is functionally coupled to MAP kinase. J Immunol. 1994 Mar 15; 152(6):2987-94. PMID: 7511635.
      Citations: 2     Fields:    Translation:HumansCells
    321. Benschop RJ, Brosschot JF, Godaert GL, De Smet MB, Geenen R, Olff M, Heijnen CJ, Ballieux RE. Chronic stress affects immunologic but not cardiovascular responsiveness to acute psychological stress in humans. Am J Physiol. 1994 Jan; 266(1 Pt 2):R75-80. PMID: 8304558.
      Citations: 12     Fields:    Translation:Humans
    322. Benschop RJ, Oostveen FG, Heijnen CJ, Ballieux RE. Beta 2-adrenergic stimulation causes detachment of natural killer cells from cultured endothelium. Eur J Immunol. 1993 Dec; 23(12):3242-7. PMID: 8258340.
      Citations: 25     Fields:    Translation:HumansCells
    323. Bohus B, Koolhaas JM, Heijnen CJ, de Boer O. Immunological responses to social stress: dependence on social environment and coping abilities. Neuropsychobiology. 1993; 28(1-2):95-9. PMID: 8255418.
      Citations: 8     Fields:    Translation:AnimalsCells
    324. Kavelaars A, Jeurissen F, von Frijtag Drabbe Künzel J, Herman van Roijen J, Rijkers GT, Heijnen CJ. Substance P induces a rise in intracellular calcium concentration in human T lymphocytes in vitro: evidence of a receptor-independent mechanism. J Neuroimmunol. 1993 Jan; 42(1):61-70. PMID: 7678598.
      Citations: 3     Fields:    Translation:HumansCells
    325. Kooijman R, Willems M, De Haas CJ, Rijkers GT, Schuurmans AL, Van Buul-Offers SC, Heijnen CJ, Zegers BJ. Expression of type I insulin-like growth factor receptors on human peripheral blood mononuclear cells. Endocrinology. 1992 Nov; 131(5):2244-50. PMID: 1425423.
      Citations: 24     Fields:    Translation:HumansCells
    326. Brosschot JF, Benschop RJ, Godaert GL, de Smet MB, Olff M, Heijnen CJ, Ballieux RE. Effects of experimental psychological stress on distribution and function of peripheral blood cells. Psychosom Med. 1992 Jul-Aug; 54(4):394-406. PMID: 1502282.
      Citations: 17     Fields:    Translation:HumansCells
    327. Peeters CC, Tenbergen-Meekes AM, Heijnen CJ, Poolman JT, Zegers JM, Rijkers GT. Interferon-gamma and interleukin-6 augment the human in vitro antibody response to the Haemophilus influenzae type b polysaccharide. J Infect Dis. 1992 Jun; 165 Suppl 1:S161-2. PMID: 1588155.
      Citations: 3     Fields:    Translation:HumansCells
    328. Kooijman R, Willems M, Rijkers GT, Brinkman A, van Buul-Offers SC, Heijnen CJ, Zegers BJ. Effects of insulin-like growth factors and growth hormone on the in vitro proliferation of T lymphocytes. J Neuroimmunol. 1992 May; 38(1-2):95-104. PMID: 1374427.
      Citations: 4     Fields:    Translation:HumansCells
    329. Chiappelli F, Kavelaars A, Heijnen CJ. Beta-endorphin effects on membrane transduction in human lymphocytes. Ann N Y Acad Sci. 1992 Apr 15; 650:211-7. PMID: 1534974.
      Citations:    Fields:    Translation:HumansCells
    330. Kavelaars A, Beetsma A, Von Frijtag Drabbe Künzel J, Heijnen CJ. Beta-endorphin 1-17 modulates high affinity IL-2 receptor expression on human T cells. Ann N Y Acad Sci. 1992 Apr 15; 650:234-8. PMID: 1376571.
      Citations:    Fields:    Translation:HumansCells
    331. Schotman-Schram P, Helders PJ, Heijnen CJ. [Stress in newborn infants: a literature review]. Tijdschr Kindergeneeskd. 1992 Apr; 60(2):27-31. PMID: 1641841.
      Citations:    Fields:    Translation:Humans
    332. Peeters CC, Tenbergen-Meekes AM, Heijnen CJ, Poolman JT, Zegers BJ, Rijkers GT. In vitro activation of human T lymphocytes by Haemophilus influenzae type b capsular polysaccharides. Scand J Immunol. 1992 Feb; 35(2):137-48. PMID: 1346727.
      Citations: 1     Fields:    Translation:HumansCells
    333. Peeters CC, Tenbergen-Meekes AM, Heijnen CJ, Poolman JT, Zegers BJ, Rijkers GT. In vitro induction of a Haemophilus influenzae type b polysaccharide-specific antibody response in human peripheral blood lymphocytes of individuals recently vaccinated with an oligosaccharide-protein conjugate. J Immunol. 1991 Dec 15; 147(12):4192-9. PMID: 1753096.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    334. Bohus B, Koolhaas JM, De Ruiter AJ, Heijnen CJ. Stress and differential alterations in immune system functions: conclusions from social stress studies in animals. Neth J Med. 1991 Oct; 39(3-4):306-15. PMID: 1791892.
      Citations: 3     Fields:    Translation:Animals
    335. Heijnen CJ, Kavelaars A, Kuis W. [The relationship between the neuroendocrine system and juvenile chronic arthritis: a hypothesis]. Tijdschr Kindergeneeskd. 1991 Oct; 59(5):182-5. PMID: 1720265.
      Citations:    Fields:    Translation:Humans
    336. Heijnen CJ, Kavelaars A. The contribution of neuroendocrine substances to the immune response. Neth J Med. 1991 Oct; 39(3-4):281-94. PMID: 1791891.
      Citations: 2     Fields:    Translation:Humans
    337. Kavelaars A, Ballieux RE, Heijnen CJ. Two different signalling pathways for the induction of immunoreactive beta-endorphin secretion by human peripheral blood mononuclear cells. Endocrinology. 1991 Feb; 128(2):765-70. PMID: 1824933.
      Citations: 2     Fields:    Translation:HumansCells
    338. Heijnen CJ, Kavelaars A, Ballieux RE. Beta-endorphin: cytokine and neuropeptide. Immunol Rev. 1991 Feb; 119:41-63. PMID: 2045122.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    339. Marwitz PA, Tenbergen-Meekes AJ, Heijnen CJ, Rijkers GT, Zegers BJ. Interleukin 1 in the in vitro antigen-induced antibody response in the human adult and newborn. Scand J Immunol. 1990 Nov; 32(5):451-9. PMID: 2148635.
      Citations: 1     Fields:    Translation:HumansCells
    340. Kavelaars A, Ballieux RE, Heijnen CJ. Differential effects of beta-endorphin on cAMP levels in human peripheral blood mononuclear cells. Brain Behav Immun. 1990 Sep; 4(3):171-9. PMID: 1964616.
      Citations: 5     Fields:    Translation:HumansCells
    341. Kavelaars A, Ballieux RE, Heijnen CJ. In vitro beta-adrenergic stimulation of lymphocytes induces the release of immunoreactive beta-endorphin. Endocrinology. 1990 Jun; 126(6):3028-32. PMID: 2161745.
      Citations: 6     Fields:    Translation:HumansCells
    342. Kavelaars A, Ballieux RE, Heijnen CJ. Beta-endorphin production by lymphocytes. Int J Neurosci. 1990 Apr; 51(3-4):173-5. PMID: 2279862.
      Citations:    Fields:    Translation:HumansCells
    343. Kavelaars A, Eggen BJ, De Graan PN, Gispen WH, Heijnen CJ. The phosphorylation of the CD3 gamma chain of T lymphocytes is modulated by beta-endorphin. Eur J Immunol. 1990 Apr; 20(4):943-5. PMID: 2140792.
      Citations: 1     Fields:    Translation:HumansCells
    344. Croiset G, Heijnen CJ, de Wied D. Passive avoidance behavior, vasopressin and the immune system. A link between avoidance latency and immune response. Neuroendocrinology. 1990 Feb; 51(2):156-61. PMID: 2106096.
      Citations: 1     Fields:    Translation:Animals
    345. Kavelaars A, Berkenbosch F, Croiset G, Ballieux RE, Heijnen CJ. Induction of beta-endorphin secretion by lymphocytes after subcutaneous administration of corticotropin-releasing factor. Endocrinology. 1990 Feb; 126(2):759-64. PMID: 2137081.
      Citations: 6     Fields:    Translation:AnimalsCells
    346. Croiset G, Heijnen CJ, van der Wal WE, de Boer SF, de Wied D. A role for the autonomic nervous system in modulating the immune response during mild emotional stimuli. Life Sci. 1990; 46(6):419-25. PMID: 2154660.
      Citations: 1     Fields:    Translation:Animals
    347. Kavelaars A, Ballieux RE, Heijnen CJ. Beta-endorphin secretion by human peripheral blood mononuclear cells: regulation by glucocorticoids. Life Sci. 1990; 46(17):1233-40. PMID: 2140145.
      Citations: 5     Fields:    Translation:HumansCells
    348. Croiset G, Ballieux RE, de Wied D, Heijnen CJ. Effects of environmental stimuli on immunoreactivity: further studies on passive avoidance behavior. Brain Behav Immun. 1989 Jun; 3(2):138-48. PMID: 2790229.
      Citations:    Fields:    Translation:AnimalsCells
    349. Kavelaars A, Ballieux RE, Heijnen CJ. The role of IL-1 in the corticotropin-releasing factor and arginine- vasopressin-induced secretion of immunoreactive beta-endorphin by human peripheral blood mononuclear cells. J Immunol. 1989 Apr 01; 142(7):2338-42. PMID: 2522482.
      Citations: 20     Fields:    Translation:HumansCells
    350. Sjamsoedin-Visser LJ, Heijnen CJ, Zegers BJ, Stoop JW. Defective T suppressor-inducer cell function in human immune deficiency virus-seropositive hemophilia patients. Blood. 1988 Nov; 72(5):1474-7. PMID: 2902886.
      Citations:    Fields:    Translation:HumansCells
    351. Hart LA, Zijlstra J, Heijnen JJ, Ballieux RE. Generation of high-rate ovalbumin-specific antibody-secreting cells in cultures of human peripheral blood B cells obtained from non-immunized blood donors. Scand J Immunol. 1988 Nov; 28(5):583-9. PMID: 2975042.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    352. Hart LA, Zijlstra J, Heijnen JJ, Ballieux RE. Ovalbumin-specific human B-cell activation and maturation. The absence of final maturation is due to the incapacity of ovalbumin-activated T cells to produce maturation factors. Scand J Immunol. 1988 Jul; 28(1):55-61. PMID: 2456606.
      Citations:    Fields:    Translation:HumansCells
    353. Kavelaars A, Ballieux RE, Heijnen C. Modulation of the immune response by proopiomelanocortin derived peptides. II. Influence of adrenocorticotropic hormone on the rise in intracellular free calcium concentration after T cell activation. Brain Behav Immun. 1988 Mar; 2(1):57-66. PMID: 3263158.
      Citations: 3     Fields:    Translation:HumansCells
    354. Zegers BJ, Marwitz PA, Peeters-Holtrop S, Rijkers GT, van der Meer JW, Heijnen CJ. Antigen presentation by monocytes of CGD-patients and by phenylbutazone treated monocytes of normal peripheral blood. Acta Paediatr Hung. 1988-1989; 29(1-2):55-7. PMID: 3255415.
      Citations:    Fields:    Translation:HumansCells
    355. Heijnen CJ, Zijlstra J, Kavelaars A, Croiset G, Ballieux RE. Modulation of the immune response by POMC-derived peptides. I. Influence on proliferation of human lymphocytes. Brain Behav Immun. 1987 Dec; 1(4):284-91. PMID: 2839258.
      Citations: 11     Fields:    Translation:HumansCells
    356. Sjamsoedin-Visser EJ, Heijnen CJ, Zegers BJ, Stoop JW. Defect in B cell function in HTLV III/LAV positive hemophilia patients. Blood. 1987 May; 69(5):1388-93. PMID: 2952185.
      Citations: 3     Fields:    Translation:HumansCells
    357. Croiset G, Heijnen CJ, Veldhuis HD, de Wied D, Ballieux RE. Modulation of the immune response by emotional stress. Life Sci. 1987 Feb 23; 40(8):775-82. PMID: 3492655.
      Citations: 4     Fields:    Translation:AnimalsCells
    358. Ballieux RE, Heijnen CJ. Brain and immune system: a one-way conversation or a genuine dialogue? Prog Brain Res. 1987; 72:71-7. PMID: 3615907.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    359. Veldhuis HD, Croiset G, Ballieux RE, Heijnen CJ, De Wied D. Emotional stress and modulation of immunological reactivity. Adv Biochem Psychopharmacol. 1987; 43:237-45. PMID: 3591513.
      Citations:    Fields:    Translation:Animals
    360. Croiset G, Veldhuis HD, Ballieux RE, de Wied D, Heijnen CJ. The impact of mild emotional stress induced by the passive avoidance procedure on immune reactivity. Ann N Y Acad Sci. 1987; 496:477-84. PMID: 3474984.
      Citations:    Fields:    Translation:AnimalsCells
    361. Heijnen CJ, Croiset G, Zijlstra J, Ballieux RE. Modulation of lymphocyte function by endorphins. Ann N Y Acad Sci. 1987; 496:161-5. PMID: 2955727.
      Citations: 2     Fields:    Translation:HumansCells
    362. Heijnen CJ, van der Meer JW, Zegers BJ. Altered antigen-presentation in the induction of the in-vitro antigen-specific T helper cell function in patients with chronic granulomatous disease. Clin Exp Immunol. 1986 Oct; 66(1):111-7. PMID: 2948743.
      Citations: 4     Fields:    Translation:HumansCells
    363. Bloem AC, Heijnen CJ, Bast BJ, Ballieux RE. T cells in B cell chronic lymphocytic leukemia. II. Lack of antigen-specific T suppressor cells and their progenitors. J Immunol. 1985 Dec; 135(6):4261-5. PMID: 2415608.
      Citations: 1     Fields:    Translation:HumansCells
    364. Hart LA, Heijnen CJ, Zijlstra J, Ballieux RE. Analysis of the antigen-induced in vitro differentiation of human peripheral blood B cells: stimulation with ovalbumin induces the transition from the resting state into the excited state. Clin Exp Immunol. 1985 Sep; 61(3):648-56. PMID: 2934190.
      Citations: 1     Fields:    Translation:HumansCells
    365. van Velzen-Blad H, Dijkstra YJ, Heijnen CJ, Schurink GA, Zegers BJ, Ballieux RE. Cardiopulmonary bypass and host defense functions in human beings: II. Lymphocyte function. Ann Thorac Surg. 1985 Mar; 39(3):212-7. PMID: 3977460.
      Citations: 4     Fields:    Translation:Humans
    366. Luijten JA, De Jong WA, Demel RA, Heijnen CJ, Ballieux RE. Peripheral nerve P2 basic protein and the Guillain-Barré syndrome. In vitro demonstration of P2-specific antibody-secreting cells. J Neurol Sci. 1984 Nov-Dec; 66(2-3):209-16. PMID: 6085109.
      Citations: 2     Fields:    Translation:HumansCells
    367. Derksen RH, Schuurman HJ, Heijnen CJ, Meekes AM, Broekhuizen R, Kater L. Cold lymphocytotoxic antibodies in systemic lupus erythematosus. Vox Sang. 1984; 46(6):366-76. PMID: 6331685.
      Citations: 1     Fields:    Translation:HumansCells
    368. Van Tol MJ, Zijlstra J, Heijnen CJ, Kuis W, Zegers BJ, Ballieux RE. Antigen-specific plaque-forming cell response of human cord blood lymphocytes after in vitro stimulation by T cell-dependent antigens. Eur J Immunol. 1983 May; 13(5):390-7. PMID: 6343096.
      Citations: 3     Fields:    Translation:HumansCells
    369. Ballieux RE, Heijnen CJ. Immunoregulatory T cell subpopulations in man: dissection by monoclonal antibodies and Fc-receptors. Immunol Rev. 1983; 74:5-28. PMID: 6226587.
      Citations: 16     Fields:    Translation:HumansCells
    370. Zegers BJ, Heijnen CJ, Roord JJ, Kuis W, Schuurman RK, Stoop JW, Ballieux RE. Defective expression of mononuclear cell membrane HLA antigens associated with combined immunodeficiency: impaired cellular interactions. Birth Defects Orig Artic Ser. 1983; 19(3):93-6. PMID: 6228275.
      Citations: 3     Fields:    Translation:HumansCells
    371. Heijnen CJ, Ballieux RE. Suppressor T-cell circuit in man. Birth Defects Orig Artic Ser. 1983; 19(3):15-20. PMID: 6228265.
      Citations:    Fields:    Translation:HumansCells
    372. Heijnen CJ, UytdeHaag F, Pot KH, Bentwich Z, Ballieux RE. Antigen-specific human T-cell factors: T-cell helper and suppressor factors, immunochemical aspects. Ann Immunol (Paris). 1982 Nov-Dec; 133D(3):221-34. PMID: 6187271.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    373. Ballieux RE, Heijnen CJ. Antigen-specific helper and suppressor T cell factors in man. Clin Haematol. 1982 Oct; 11(3):711-8. PMID: 6217009.
      Citations:    Fields:    Translation:HumansAnimalsCells
    374. Heijnen CJ, Pot KH, Ballieux RE. Characterization of human T suppressor-inducer, -precursor and -effector lymphocytes in the antigen-specific plaque-forming cell response. Eur J Immunol. 1982 Oct; 12(10):860-6. PMID: 6184239.
      Citations: 9     Fields:    Translation:HumansCells
    375. Feller AC, Heijnen CJ, Ballieux RE, Parwaresch MR. Enzymehistochemical staining of T mu lymphocytes for glycyl-proline-4-methoxy-beta-naphthylamide-peptidase (DAP IV). Br J Haematol. 1982 Jun; 51(2):227-34. PMID: 6123345.
      Citations: 16     Fields:    Translation:HumansCells
    376. Heijnen CJ, Pot KH, Kater L, Kluin-Nelemans HC, Uytdehaag F, Ballieux RE. Functional analysis of the defective T cell regulation of the antigen-specific PFC response in SLE patients: differentiation of suppressor precursor cells to suppressor effector cells. Clin Exp Immunol. 1982 Feb; 47(2):359-67. PMID: 6210474.
      Citations: 4     Fields:    Translation:HumansCells
    377. Uytdehaag F, Heijnen CJ, Pot KH, Ballieux RE. Antigen-specific human T cell factors. II. T cell suppressor factor: biologic properties. J Immunol. 1981 Feb; 126(2):503-7. PMID: 6161176.
      Citations: 7     Fields:    Translation:HumansCells
    378. Heijnen CJ, Uytdehaag F, Pot KH, Ballieux RE. Antigen-specific human T cell factors. I. T cell helper factor: biololgic properties. J Immunol. 1981 Feb; 126(2):497-502. PMID: 6161175.
      Citations: 4     Fields:    Translation:HumansCells
    379. Heijnen CJ, UytdeHaag F, Ballieux RE. In vitro antibody response of human lymphocytes. Springer Semin Immunopathol. 1980 May; 3(1):63-92. PMID: 6792726.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    380. Heijnen CJ, Uytdehaag F, Pot CH, Ballieux RE. Feedback inhibition by human primed T-helper cells. Nature. 1979 Aug 16; 280(5723):589-91. PMID: 313527.
      Citations: 7     Fields:    Translation:HumansCells
    381. Uytdehaag F, Heijnen CJ, Pot KH, Ballieux RE. T-T interactions in the induction of antigen-specific human suppressor T lymphocytes in vitro. J Immunol. 1979 Aug; 123(2):646-53. PMID: 88481.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    382. Heijnen CJ, UytdeHaag F, Gmelig-Meyling FH, Ballieux RE. Localization of human antigen-specific helper and suppressor function in distinct T-cell subpopulations. Cell Immunol. 1979 Mar 15; 43(2):282-92. PMID: 314342.
      Citations: 19     Fields:    Translation:HumansCells
    383. Ballieux RE, Heijnen CJ, Uytdehaag F, Zegers BJ. Regulation of B cell activity in man: role of T cells. Immunol Rev. 1979; 45:3-39. PMID: 89731.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    384. Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2. Science Signaling. 8.
    385. Co-operative T-T interactions in the human T suppressor cell circuit. Immunology Today. 2:188-189.
    386. Long-term effects of perinatal glucocorticoid treatment on the heart. Current Pediatric Reviews. 3:190-197.
    387. Executive functioning and diabetes. Psychoneuroendocrinology. 71:102-109.
    388. Mesenchymal stem cells attenuate MRI-identifiable injury, protect white matter, and improve long-term functional outcomes after neonatal focal stroke in rats. Journal of Neuroscience Research.
    389. The effects of surgical stress and psychological stress on the immune function of operative cancer patients. Psychology and Health. 13:1015-1026.
    390. Chronic stress affects immunologic but not cardiovascular responsiveness to acute psychological stress in humans. AM.J.PHYSIOL. 266.
    391. Dorsal Root Ganglion Infiltration by Macrophages Contributes to Paclitaxel Chemotherapy-Induced Peripheral Neuropathy. Journal of Pain. 17:775-786.
    392. Antwoord aan Maes en Twisk. Tijdschrift voor Psychiatrie. 51:784-786.
    393. Acetylsalicylic acid as an adjuvant therapy for schizophrenia. Trials. 7.
    394. Antwoord aan Den Broeder en Arnoldus. Tijdschrift voor Psychiatrie. 51:787-788.
    395. Reprint of. Reproductive BioMedicine Online. 27:673-688.
    396. Mechanisms of chemotherapy-induced behavioral toxicities. Frontiers in Neuroscience. 9.
    397. Neural and endocrine effects on immunity. 39-43.
    398. The role of the basic protein P2 in the pathogenesis of the Guillain-Barré syndrome (G.B.S.). Clinical Neurology and Neurosurgery. 88:70.
    399. Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1. Scientific Reports. 6.
    400. Impaired oligodendrocyte maturation in preterm infants. Progress in Neurobiology. 136:28-49.
    401. The relation of the psyche and the immune response. 201-205.
    402. Induced mild psychological stress and human immune response. International Journal of Psychophysiology. 7:155-156.
    403. Neonatale behandeling met corticosteroïden en consequenties op de lange termijn. Tijdschrift voor Kindergeneeskunde. 69:91-97.
    404. Psychoneuroimmunology and the course of breast cancer. Psycho-Oncology. 3:271-288.
    405. Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain, Behavior, and Immunity. 46:147-153.
    406. Interactions between corticotropin-releasing hormone and interleukin-1 in the immune system. Annals of the New York Academy of Sciences. 594:368-370.
    407. Metformin prevents cisplatin-induced cognitive impairment and brain damage in mice. PLoS One. 11.
    408. CD8+ T cells and endogenous IL-10 are required for resolution of chemotherapy-induced neuropathic pain. Journal of Neuroscience. 36:11074-11083.
    409. Editorial. Netherlands Journal of Medicine. 39:181-182.
    410. IL4-10 fusion protein is a Novel drug to Treat persistent inflammatory pain. Journal of Neuroscience. 36:7353-7363.
    411. Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ. Pain. 156:2184-2192.
    412. Immuunmodulerende effecten van leukocyten-verwijdering bij neonatale bloedtransfusie. Tijdschrift voor Kindergeneeskunde. 66:5-6.
    413. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proceedings of the National Academy of Sciences of the United States of America. 113:3036-3041.
    414. Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. Current Neuropharmacology. 8:324-334.
    415. The seven vells of Immune conditioning. Behavioral and Brain Sciences. 8:396-397.
    416. Effects of experimental psychological stress on T-lymphocytes and NK cells in man. Journal of Psychophysiology. 5:59-67.
    417. Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice. Pediatric Research. 81:127-135.
    418. Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse. Pediatric Research. 78:520-526.
    419. Long-term functional consequences and ongoing cerebral inflammation after subarachnoid hemorrhage in the rat. PLoS One. 9.
    420. Sickness behavior induced by cisplatin chemotherapy and radiotherapy in a murine head and neck cancer model is associated with altered mitochondrial gene expression. Behavioural Brain Research. 297:241-250.
    421. Regulation of Target System Sensitivity in Neuroinflammation.
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