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CARLOS CAULIN

TitleAssociate Professor
InstitutionMD Anderson
DepartmentHead & Neck Surgery
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Collapse Research 
    Collapse research activities and funding
    R01DE015344     (CAULIN, CARLOS)Jan 13, 2005 - Dec 31, 2010
    NIH/NIDCR
    Inductible mouse models for oral cancer
    Role: Principal Investigator

    R21DE023656     (CAULIN, CARLOS)Jul 10, 2014 - Jun 30, 2016
    NIH/NIDCR
    Role of MYB and MYB-NFIB fusions in Salivary Adenoid Cystic Carcinoma
    Role: Principal Investigator

    R01DE026735     (CAULIN, CARLOS)Jan 1, 2018 - Dec 31, 2022
    NIH/NIDCR
    Mechanisms of Adenoid Cystic Carcinoma Development and Tumor Maintenance
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wang J, Xie T, Wang B, William WN, Heymach JV, El-Naggar AK, Myers JN, Caulin C. PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions. Cancer Prev Res (Phila). 2017 Dec; 10(12):684-693. PMID: 29018057.
      View in: PubMed
    2. Li Z, Gonzalez CL, Wang B, Zhang Y, Mejia O, Katsonis P, Lichtarge O, Myers JN, El-Naggar AK, Caulin C. Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H). J Pathol. 2016 10; 240(2):224-34. PMID: 27447534.
      View in: PubMed
    3. Foy JP, Tortereau A, Caulin C, Le Texier V, Lavergne E, Thomas E, Chabaud S, Perol D, Lachuer J, Lang W, Hong WK, Goudot P, Lippman SM, Bertolus C, Saintigny P. The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. Oncotarget. 2016 Jun 14; 7(24):35932-35945. PMID: 27027432.
      View in: PubMed
    4. Mitani Y, Liu B, Rao PH, Borra VJ, Zafereo M, Weber RS, Kies M, Lozano G, Futreal PA, Caulin C, El-Naggar AK. Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clin Cancer Res. 2016 Feb 01; 22(3):725-33. PMID: 26631609; PMCID: PMC4807116 [Available on 02/01/17].
    5. Tanaka N, Patel AA, Wang J, Frederick MJ, Kalu NN, Zhao M, Fitzgerald AL, Xie TX, Silver NL, Caulin C, Zhou G, Skinner HD, Johnson FM, Myers JN, Osman AA. Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins. Clin Cancer Res. 2015 Nov 01; 21(21):4831-44. PMID: 26124202.
      View in: PubMed
    6. Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O. Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res. 2015 Apr 01; 75(7):1527-36. PMID: 25634208; PMCID: PMC4383697.
    7. Li X, Moses RE, Jin J, Cao W, Caulin C. Stresses, aging, and age-related disorders. Oxid Med Cell Longev. 2014; 2014:320564. PMID: 25610525; PMCID: PMC4293784.
    8. Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN. Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19. PMID: 25504633; PMCID: PMC4557970.
    9. Mitani Y, Rao PH, Maity SN, Lee YC, Ferrarotto R, Post JC, Licitra L, Lippman SM, Kies MS, Weber RS, Caulin C, Lin SH, El-Naggar AK. Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications. Clin Cancer Res. 2014 Dec 15; 20(24):6570-81. PMID: 25316813; PMCID: PMC4268116.
    10. Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, Tsai KY, Curry JL, Tetzlaff MT, Lai SY, Yu J, Muzny DM, Doddapaneni H, Shinbrot E, Covington KR, Zhang J, Seth S, Caulin C, Clayman GL, El-Naggar AK, Gibbs RA, Weber RS, Myers JN, Wheeler DA, Frederick MJ. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 2014 Dec 15; 20(24):6582-92. PMID: 25303977; PMCID: PMC4367811.
    11. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell. 2014 Jun 19; 54(6):960-74. PMID: 24857548.
      View in: PubMed
    12. Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and av integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. 2015 Jan 22; 34(4):516-24. PMID: 24469034; PMCID: PMC4303549.
    13. Zhang L, Mitani Y, Caulin C, Rao PH, Kies MS, Saintigny P, Zhang N, Weber RS, Lippman SM, El-Naggar AK. Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance. Am J Pathol. 2013 Jun; 182(6):2048-57. PMID: 23583282; PMCID: PMC3668022.
    14. Caulin C. Modeling squamous cell carcinoma development and malignant progression in mice. BMC Proc. 2013; 7 Suppl 2:K3. PMID: 24764482; PMCID: PMC3624509.
    15. Ali A, Wang Z, Fu J, Ji L, Liu J, Li L, Wang H, Chen J, Caulin C, Myers JN, Zhang P, Xiao J, Zhang B, Li X. Differential regulation of the REG?-proteasome pathway by p53/TGF-ß signalling and mutant p53 in cancer cells. Nat Commun. 2013; 4:2667. PMID: 24157709; PMCID: PMC3876931.
    16. Mitani Y, Rao PH, Futreal PA, Roberts DB, Stephens PJ, Zhao YJ, Zhang L, Mitani M, Weber RS, Lippman SM, Caulin C, El-Naggar AK. Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. Clin Cancer Res. 2011 Nov 15; 17(22):7003-14. PMID: 21976542.
      View in: PubMed
    17. Torchia EC, Caulin C, Acin S, Terzian T, Kubick BJ, Box NF, Roop DR. Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma. Oncogene. 2012 May 24; 31(21):2680-90. PMID: 21963848; PMCID: PMC4576849.
    18. Acin S, Li Z, Mejia O, Roop DR, El-Naggar AK, Caulin C. Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras. J Pathol. 2011 Dec; 225(4):479-89. PMID: 21952947; PMCID: PMC4302750.
    19. Sano D, Xie TX, Ow TJ, Zhao M, Pickering CR, Zhou G, Sandulache VC, Wheeler DA, Gibbs RA, Caulin C, Myers JN. Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer. Clin Cancer Res. 2011 Nov 01; 17(21):6658-70. PMID: 21903770.
      View in: PubMed
    20. Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK. Expression and regulation of the ?N and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings. Am J Pathol. 2011 Jul; 179(1):391-9. PMID: 21703418; PMCID: PMC3123859.
    21. Mitani Y, Li J, Rao PH, Zhao YJ, Bell D, Lippman SM, Weber RS, Caulin C, El-Naggar AK. Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res. 2010 Oct 01; 16(19):4722-31. PMID: 20702610.
      View in: PubMed
    22. Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res. 2009 Sep 15; 69(18):7207-15. PMID: 19738056; PMCID: PMC2745523.
    23. Caulin C, Nguyen T, Lang GA, Goepfert TM, Brinkley BR, Cai WW, Lozano G, Roop DR. An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest. 2007 Jul; 117(7):1893-901. PMID: 17607363; PMCID: PMC1904325.
    24. Chen J, Cheng X, Merched-Sauvage M, Caulin C, Roop DR, Koch PJ. An unexpected role for keratin 10 end domains in susceptibility to skin cancer. J Cell Sci. 2006 Dec 15; 119(Pt 24):5067-76. PMID: 17118961.
      View in: PubMed
    25. Caulin C, Nguyen T, Longley MA, Zhou Z, Wang XJ, Roop DR. Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity. Cancer Res. 2004 Aug 01; 64(15):5054-8. PMID: 15289303.
      View in: PubMed
    26. Caulin C, Ware CF, Magin TM, Oshima RG. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol. 2000 Apr 03; 149(1):17-22. PMID: 10747083; PMCID: PMC2175089.
    27. Caulín C, Salvesen GS, Oshima RG. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol. 1997 Sep 22; 138(6):1379-94. PMID: 9298992; PMCID: PMC2132555.
    28. Oshima RG, Baribault H, Caulín C. Oncogenic regulation and function of keratins 8 and 18. Cancer Metastasis Rev. 1996 Dec; 15(4):445-71. PMID: 9034603.
      View in: PubMed
    29. Caulín C, López-Barcons L, Gonzáles-Garrigues M, Navarro P, Lozano E, Rodrigo I, Gamallo C, Cano A, Fabra A, Quintanilla M. Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced Ha-ras oncogene products. Mol Carcinog. 1996 Feb; 15(2):104-14. PMID: 8599577.
      View in: PubMed
    30. Caulín C, Scholl FG, Frontelo P, Gamallo C, Quintanilla M. Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ. 1995 Aug; 6(8):1027-35. PMID: 8547217.
      View in: PubMed
    31. Caulín C, Bauluz C, Gandarillas A, Cano A, Quintanilla M. Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes. Exp Cell Res. 1993 Jan; 204(1):11-21. PMID: 7677983.
      View in: PubMed
    32. Reply to. Journal of Cell Science. 120:1147-1148.
    33. Wee-1 kinase inhibition sensitizes high-risk HPV+ HNSCC to apoptosis accompanied by downregulation of MCl-1 and XIAP antiapoptotic proteins. Clinical Cancer Research. 21:4831-4844.
    34. The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. Oncotarget. 7:35932-35945.
    35. Evolutionary action score of TP53 identifies high-risk mutations associated with decreased survival and increased distant metastases in head and neck cancer. Cancer Research. 75:1527-1536.
    36. Ras oncogenes in chemical carcinogenesis. Oncologia. 14:101-106.
    37. Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clinical Cancer Research. 22:725-733.
    38. Animal models of oral cancer metastasis. 135-161.
    39. Expression of intermediate filament proteins by normal and transformed mouse epidermal keratinocytes in culture. International Journal of Oncology. 2:373-379.
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