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ASHA S MULTANI

Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Veletic I, Manshouri T, Multani AS, Yin CC, Chen L, Verstovsek S, Estrov Z. Myelofibrosis osteoclasts are clonal and functionally impaired. Blood. 2019 Feb 11. PMID: 30745304.
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    2. Long DJ, Gaikwad A, Multani A, Pathak S, Montgomery CA, Gonzalez FJ, Jaiswal AK. Retraction: Disruption of the NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Gene in Mice Causes Myelogenous Hyperplasia. Cancer Res. 2018 Nov 15; 78(22):6526. PMID: 30442815.
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    3. Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host Microbe. 2018 09 12; 24(3):392-404.e8. PMID: 30173955.
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    4. Wang M, Liang L, Lei X, Multani A, Meric-Bernstam F, Tripathy D, Wu Y, Chen H, Zhang H. Evaluation of cMET aberration by immunohistochemistry and fluorescence in situ hybridization (FISH) in triple negative breast cancers. Ann Diagn Pathol. 2018 Aug; 35:69-76. PMID: 29843069.
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    5. deCarvalho AC, Kim H, Poisson LM, Winn ME, Mueller C, Cherba D, Koeman J, Seth S, Protopopov A, Felicella M, Zheng S, Multani A, Jiang Y, Zhang J, Nam DH, Petricoin EF, Chin L, Mikkelsen T, Verhaak RGW. Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma. Nat Genet. 2018 05; 50(5):708-717. PMID: 29686388.
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    6. Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res. 2018 04; 28(4):432-447. PMID: 29567676.
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    7. Ong DST, Hu B, Ho YW, Sauvé CG, Bristow CA, Wang Q, Multani AS, Chen P, Nezi L, Jiang S, Gorman CE, Monasterio MM, Koul D, Marchesini M, Colla S, Jin EJ, Sulman EP, Spring DJ, Yung WA, Verhaak RGW, Chin L, Wang YA, DePinho RA. PAF promotes stemness and radioresistance of glioma stem cells. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9086-E9095. PMID: 29073105.
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    8. Graham NA, Minasyan A, Lomova A, Cass A, Balanis NG, Friedman M, Chan S, Zhao S, Delgado A, Go J, Beck L, Hurtz C, Ng C, Qiao R, Ten Hoeve J, Palaskas N, Wu H, Müschen M, Multani AS, Port E, Larson SM, Schultz N, Braas D, Christofk HR, Mellinghoff IK, Graeber TG. Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol. 2017 02 15; 13(2):914. PMID: 28202506.
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    9. Rai R, Multani AS, Chang S. Cytogenetic Analysis of Telomere Dysfunction. Methods Mol Biol. 2017; 1587:127-131. PMID: 28324504.
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    10. Niu N, Zhang J, Zhang N, Mercado-Uribe I, Tao F, Han Z, Pathak S, Multani AS, Kuang J, Yao J, Bast RC, Sood AK, Hung MC, Liu J. Linking genomic reorganization to tumor initiation via the giant cell cycle. Oncogenesis. 2016 Dec 19; 5(12):e281. PMID: 27991913.
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    11. Sneige N, Hess KR, Multani AS, Gong Y, Ibrahim NK. Prognostic significance of equivocal human epidermal growth factor receptor 2 results and clinical utility of alternative chromosome 17 genes in patients with invasive breast cancer: A cohort study. Cancer. 2017 04 01; 123(7):1115-1123. PMID: 27893937.
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    12. Sun Y, Ji P, Chen T, Zhou X, Yang D, Guo Y, Liu Y, Hu L, Xia D, Liu Y, Multani AS, Shmulevich I, Kucherlapati R, Kopetz S, Sood AK, Hamilton SR, Sun B, Zhang W. MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. J Pathol. 2017 Jan; 241(1):67-79. PMID: 27741356.
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    13. Verstovsek S, Manshouri T, Pilling D, Bueso-Ramos CE, Newberry KJ, Prijic S, Knez L, Bozinovic K, Harris DM, Spaeth EL, Post SM, Multani AS, Rampal RK, Ahn J, Levine RL, Creighton CJ, Kantarjian HM, Estrov Z. Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis. J Exp Med. 2016 08 22; 213(9):1723-40. PMID: 27481130.
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    14. McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Correction: Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS One. 2016; 11(3):e0151121. PMID: 26953790.
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    15. Gallardo M, Lee HJ, Zhang X, Bueso-Ramos C, Pageon LR, McArthur M, Multani A, Nazha A, Manshouri T, Parker-Thornburg J, Rapado I, Quintas-Cardama A, Kornblau SM, Martinez-Lopez J, Post SM. hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell. 2015 Oct 12; 28(4):486-499. PMID: 26412324.
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    16. McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS One. 2015; 10(9):e0136851. PMID: 26325287.
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    17. Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 2015 May 11; 27(5):644-57. PMID: 25965571.
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    18. Riley MF, You MJ, Multani AS, Lozano G. Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. Oncogene. 2016 Jan 21; 35(3):358-65. PMID: 25915849.
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    19. Wang Y, Waters J, Leung ML, Unruh A, Roh W, Shi X, Chen K, Scheet P, Vattathil S, Liang H, Multani A, Zhang H, Zhao R, Michor F, Meric-Bernstam F, Navin NE. Clonal evolution in breast cancer revealed by single nucleus genome sequencing. Nature. 2014 Aug 14; 512(7513):155-60. PMID: 25079324.
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    20. Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach JV, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013 Dec; 123(12):5231-46. PMID: 24200691.
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    21. Malouf GG, Monzon FA, Couturier J, Molinié V, Escudier B, Camparo P, Su X, Yao H, Tamboli P, Lopez-Terrada D, Picken M, Garcia M, Multani AS, Pathak S, Wood CG, Tannir NM. Genomic heterogeneity of translocation renal cell carcinoma. Clin Cancer Res. 2013 Sep 01; 19(17):4673-84. PMID: 23817689.
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    22. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013 Sep; 23(9):1446-61. PMID: 23796952.
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    23. Chen X, Liu B, Li Q, Honorio S, Liu X, Liu C, Multani AS, Calhoun-Davis T, Tang DG. Dissociated primary human prostate cancer cells coinjected with the immortalized Hs5 bone marrow stromal cells generate undifferentiated tumors in NOD/SCID-? mice. PLoS One. 2013; 8(2):e56903. PMID: 23451107.
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    24. Yang G, Mercado-Uribe I, Multani AS, Sen S, Shih IeM, Wong KK, Gershenson DM, Liu J. RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer. 2013 Jul 15; 133(2):275-85. PMID: 23319376.
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    25. Maiti SN, Huls H, Singh H, Dawson M, Figliola M, Olivares S, Rao P, Zhao YJ, Multani A, Yang G, Zhang L, Crossland D, Ang S, Torikai H, Rabinovich B, Lee DA, Kebriaei P, Hackett P, Champlin RE, Cooper LJ. Sleeping beauty system to redirect T-cell specificity for human applications. J Immunother. 2013 Feb; 36(2):112-23. PMID: 23377665.
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    26. Singh MM, Howard A, Irwin ME, Gao Y, Lu X, Multani A, Chandra J. Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia. PLoS One. 2012; 7(12):e51611. PMID: 23284724.
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    27. Chandey M, Multani AS. A comparative study of efficacy and safety of azithromycin and ofloxacin in uncomplicated typhoid Fever: a randomised, open labelled study. J Clin Diagn Res. 2012 Dec; 6(10):1736-9. PMID: 23373040.
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    28. Ramirez E, Singh RR, Kunkalla K, Liu Y, Qu C, Cain C, Multani AS, Lennon PA, Jackacky J, Ho M, Dawud S, Gu J, Yang S, Hu PC, Vega F. Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphoma. Leuk Res. 2012 Oct; 36(10):1267-73. PMID: 22809693.
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    29. Akbay EA, Peña CG, Ruder D, Michel JA, Nakada Y, Pathak S, Multani AS, Chang S, Castrillon DH. Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis. Oncogene. 2013 Apr 25; 32(17):2211-9. PMID: 22689059.
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    30. Nanos-Webb A, Jabbour NA, Multani AS, Wingate H, Oumata N, Galons H, Joseph B, Meijer L, Hunt KK, Keyomarsi K. Targeting low molecular weight cyclin E (LMW-E) in breast cancer. Breast Cancer Res Treat. 2012 Apr; 132(2):575-88. PMID: 21695458.
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    31. Deriano L, Chaumeil J, Coussens M, Multani A, Chou Y, Alekseyenko AV, Chang S, Skok JA, Roth DB. The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature. 2011 Mar 03; 471(7336):119-23. PMID: 21368836.
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    32. Multani AS, Chang S. Cytogenetic analysis of telomere dysfunction. Methods Mol Biol. 2011; 735:139-43. PMID: 21461818.
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    33. Rai R, Zheng H, He H, Luo Y, Multani A, Carpenter PB, Chang S. The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J. 2010 Aug 04; 29(15):2598-610. PMID: 20588252.
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    34. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15; 16(12):3171-81. PMID: 20423983.
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    35. Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K. BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet. 2010 Jan 22; 6(1):e1000826. PMID: 20107607.
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    36. Thalmann GN, Rhee H, Sikes RA, Pathak S, Multani A, Zhau HE, Marshall FF, Chung LW. Human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in LNCaP Cells. Eur Urol. 2010 Jul; 58(1):162-71. PMID: 19747763.
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    37. Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent SY. Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell. 2009 Aug 14; 35(3):352-64. PMID: 19683498.
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    38. Vega F, Davuluri Y, Cho-Vega JH, Singh RR, Ma S, Wang RY, Multani AS, Drakos E, Pham LV, Lee YC, Shen L, Ambrus J, Medeiros LJ, Ford RJ. Side population of a murine mantle cell lymphoma model contains tumour-initiating cells responsible for lymphoma maintenance and dissemination. J Cell Mol Med. 2010 Jun; 14(6B):1532-45. PMID: 19656242.
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    39. Jaiswal AS, Aneja R, Connors SK, Joshi HC, Multani AS, Pathak S, Narayan S. 9-bromonoscapine-induced mitotic arrest of cigarette smoke condensate-transformed breast epithelial cells. J Cell Biochem. 2009 Apr 15; 106(6):1146-56. PMID: 19229861.
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    40. Sung SY, Hsieh CL, Law A, Zhau HE, Pathak S, Multani AS, Lim S, Coleman IM, Wu LC, Figg WD, Dahut WL, Nelson P, Lee JK, Amin MB, Lyles R, Johnstone PA, Marshall FF, Chung LW. Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis. Cancer Res. 2008 Dec 01; 68(23):9996-10003. PMID: 19047182.
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    41. He H, Wang Y, Guo X, Ramchandani S, Ma J, Shen MF, Garcia DA, Deng Y, Multani AS, You MJ, Chang S. Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol. 2009 Jan; 29(1):229-40. PMID: 18936156.
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    42. Li ZG, Mathew P, Yang J, Starbuck MW, Zurita AJ, Liu J, Sikes C, Multani AS, Efstathiou E, Lopez A, Wang J, Fanning TV, Prieto VG, Kundra V, Vazquez ES, Troncoso P, Raymond AK, Logothetis CJ, Lin SH, Maity S, Navone NM. Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest. 2008 Aug; 118(8):2697-710. PMID: 18618013.
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    43. Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward SW, Tang DG. Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells. J Biol Chem. 2008 Oct 10; 283(41):27957-72. PMID: 18662989.
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    44. Bhatia B, Multani AS, Patrawala L, Chen X, Calhoun-Davis T, Zhou J, Schroeder L, Schneider-Broussard R, Shen J, Pathak S, Chang S, Tang DG. Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT. Int J Cancer. 2008 Apr 01; 122(7):1483-95. PMID: 18059027.
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    45. Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M. Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature. 2008 Mar 20; 452(7185):365-9. PMID: 18354482.
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    46. Singh B, Cook KR, Vincent L, Hall CS, Berry JA, Multani AS, Lucci A. Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. J Surg Res. 2008 Jun 15; 147(2):240-6. PMID: 18498876.
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    47. Arora V, Nijjar IB, Multani AS, Singh JP, Abrol R, Chopra R, Attri R. MRI findings in methanol intoxication: a report of two cases. Br J Radiol. 2007 Oct; 80(958):e243-6. PMID: 17959915.
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    48. Akli S, Van Pelt CS, Bui T, Multani AS, Chang S, Johnson D, Tucker S, Keyomarsi K. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res. 2007 Aug 01; 67(15):7212-22. PMID: 17671189.
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    49. Singh B, Vincent L, Berry JA, Multani AS, Lucci A. Cyclooxygenase-2 expression induces genomic instability in MCF10A breast epithelial cells. J Surg Res. 2007 Jun 15; 140(2):220-6. PMID: 17418864.
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    50. Cosme-Blanco W, Shen MF, Lazar AJ, Pathak S, Lozano G, Multani AS, Chang S. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 2007 May; 8(5):497-503. PMID: 17396137.
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    51. Multani AS, Chang S. WRN at telomeres: implications for aging and cancer. J Cell Sci. 2007 Mar 01; 120(Pt 5):713-21. PMID: 17314245.
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    52. Ford RJ, Shen L, Lin-Lee YC, Pham LV, Multani A, Zhou HJ, Tamayo AT, Zhang C, Hawthorn L, Cowell JK, Ambrus JL. Development of a murine model for blastoid variant mantle-cell lymphoma. Blood. 2007 Jun 01; 109(11):4899-906. PMID: 17311992.
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    53. Xu J, Wang R, Xie ZH, Odero-Marah V, Pathak S, Multani A, Chung LW, Zhau HE. Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis. Prostate. 2006 Nov 01; 66(15):1664-73. PMID: 16902972.
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    54. He H, Multani AS, Cosme-Blanco W, Tahara H, Ma J, Pathak S, Deng Y, Chang S. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J. 2006 Nov 01; 25(21):5180-90. PMID: 17053789.
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    55. Qutob SS, Multani AS, Pathak S, McNamee JP, Bellier PV, Liu QY, Ng CE. Fractionated X-radiation treatment can elicit an inducible-like radioprotective response that is not dependent on the intrinsic cellular X-radiation resistance/sensitivity. Radiat Res. 2006 Oct; 166(4):590-9. PMID: 17007548.
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    56. Kupferman ME, Patel V, Sriuranpong V, Amornphimoltham P, Jasser SA, Mandal M, Zhou G, Wang J, Coombes K, Multani A, Pathak S, Silvio Gutkind J, Myers JN. Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma. Oral Oncol. 2007 May; 43(5):440-54. PMID: 16978912.
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    57. Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 Aug; 10(2):145-57. PMID: 16872911.
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    58. Wu L, Multani AS, He H, Cosme-Blanco W, Deng Y, Deng JM, Bachilo O, Pathak S, Tahara H, Bailey SM, Deng Y, Behringer RR, Chang S. Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell. 2006 Jul 14; 126(1):49-62. PMID: 16839876.
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    59. Pathak S, Multani AS. Aneuploidy, stem cells and cancer. EXS. 2006; (96):49-64. PMID: 16383014.
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    60. Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 2005 Nov 01; 19(21):2560-70. PMID: 16264192.
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    61. Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell. 2005 May; 7(5):469-83. PMID: 15894267.
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    62. Chen JS, Konopleva M, Andreeff M, Multani AS, Pathak S, Mehta K. Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosis. J Cell Physiol. 2004 Aug; 200(2):223-34. PMID: 15174092.
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    63. Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet. 2004 Aug; 36(8):877-82. PMID: 15235603.
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    64. Akli S, Zheng PJ, Multani AS, Wingate HF, Pathak S, Zhang N, Tucker SL, Chang S, Keyomarsi K. Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancer. Cancer Res. 2004 May 01; 64(9):3198-208. PMID: 15126360.
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    65. Qutob SS, Multani AS, Pathak S, Feng Y, Kendal WS, Ng CE. Comparison of the X-radiation, drug and ultraviolet-radiation responses of clones isolated from a human colorectal tumor cell line. Radiat Res. 2004 Mar; 161(3):326-34. PMID: 14982481.
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    66. Jaiswal AS, Multani AS, Pathak S, Narayan S. N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol Cancer. 2004 Jan 16; 3:3. PMID: 14728717.
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    67. Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK, Multani A, Chang S, Lozano G. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet. 2004 Jan; 36(1):63-8. PMID: 14702042.
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    68. Pathak S, Multani AS, Banerji P, Banerji P. Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer. Int J Oncol. 2003 Oct; 23(4):975-82. PMID: 12963976.
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    69. Strickland FM, Pathak S, Multani AS, Pelley RP, Donawho CK. Molecular characterization of new melanoma cell lines from C3H mice induced by ethanol plus ultraviolet radiation. Cancer Res. 2003 Jul 01; 63(13):3503-10. PMID: 12839934.
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    70. Chinni SR, Alhasan SA, Multani AS, Pathak S, Sarkar FH. Pleotropic effects of genistein on MCF-7 breast cancer cells. Int J Mol Med. 2003 Jul; 12(1):29-34. PMID: 12792805.
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    71. Zhang X, Multani AS, Zhou JH, Shay JW, McConkey D, Dong L, Kim CS, Rosser CJ, Pathak S, Benedict WF. Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells. Cancer Res. 2003 Feb 15; 63(4):760-5. PMID: 12591722.
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    72. Mehta K, Devarajan E, Chen J, Multani A, Pathak S. Multidrug-resistant MCF-7 cells: an identity crisis? J Natl Cancer Inst. 2002 Nov 06; 94(21):1652-4; author reply 1654. PMID: 12419794.
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    73. Sohn SH, Multani AS, Gugnani PK, Pathak S. Telomere erosion-induced mitotic catastrophe in continuously grown chinese hamster don cells. Exp Cell Res. 2002 Oct 01; 279(2):271-6. PMID: 12243752.
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    74. Weber KL, Pathak S, Multani AS, Price JE. Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse model. J Urol. 2002 Aug; 168(2):774-9. PMID: 12131367.
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    75. Long DJ, Gaikwad A, Multani A, Pathak S, Montgomery CA, Gonzalez FJ, Jaiswal AK. Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia. Cancer Res. 2002 Jun 01; 62(11):3030-6. PMID: 12036909.
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    76. Devarajan E, Chen J, Multani AS, Pathak S, Sahin AA, Mehta K. Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic features. Int J Oncol. 2002 May; 20(5):913-20. PMID: 11956583.
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    77. Pathak S, Multani AS, Furlong CL, Sohn SH. Telomere dynamics, aneuploidy, stem cells, and cancer (review). Int J Oncol. 2002 Mar; 20(3):637-41. PMID: 11836581.
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    78. Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal KS. Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. Oncogene. 2002 Jan 31; 21(6):878-89. PMID: 11840333.
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    79. Multani AS, Worth LL, Jeha S, Chan KW, Pathak S. Human bone marrow transplant rejection is associated with telomere cleavage. Int J Mol Med. 2001 Dec; 8(6):607-10. PMID: 11712073.
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    80. Fishman P, Bar-Yehuda S, Barer F, Madi L, Multani AS, Pathak S. The A3 adenosine receptor as a new target for cancer therapy and chemoprotection. Exp Cell Res. 2001 Oct 01; 269(2):230-6. PMID: 11570815.
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    81. Narayan S, Jaiswal AS, Multani AS, Pathak S. DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: role of telomere repeat binding factor 2. Br J Cancer. 2001 Sep 14; 85(6):898-901. PMID: 11556843.
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    82. Multani AS, Ozen M, Furlong CL, Zhao YJ, Hsu TC, Pathak S. Heterochromatin and interstitial telomeric DNA homology. Chromosoma. 2001 Jul; 110(3):214-20. PMID: 11513296.
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    83. Rhee HW, Zhau HE, Pathak S, Multani AS, Pennanen S, Visakorpi T, Chung LW. Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel. In Vitro Cell Dev Biol Anim. 2001 Mar; 37(3):127-40. PMID: 11370803.
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    84. Pathak S, Multani AS, McConkey DJ, Imam AS, Amoss MS. Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion. Int J Oncol. 2000 Dec; 17(6):1219-24. PMID: 11078808.
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    85. Fishman P, Bar-Yehuda S, Ohana G, Pathak S, Wasserman L, Barer F, Multani AS. Adenosine acts as an inhibitor of lymphoma cell growth: a major role for the A3 adenosine receptor. Eur J Cancer. 2000 Jul; 36(11):1452-8. PMID: 10899660.
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    86. Pathak S, Multani AS, Narayan S, Kumar V, Newman RA. Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells. Anticancer Drugs. 2000 Jul; 11(6):455-63. PMID: 11001386.
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    87. Multani AS, Ozen M, Narayan S, Kumar V, Chandra J, McConkey DJ, Newman RA, Pathak S. Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia. 2000 Jul-Aug; 2(4):339-45. PMID: 11005568.
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    88. Pratesi G, Tortoreto M. Human tumor xenografts in nude mice are not always of human origin. A warning signal. Cancer. 1999 Sep 01; 86(5):898-900. PMID: 10463991.
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    89. Multani AS, Ozen M, Sen S, Mandal AK, Price JE, Fan D, Radinsky R, Ali-Osman F, Von Eschenbach AC, Fidler IJ, Pathak S. Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. Int J Oncol. 1999 Sep; 15(3):423-9. PMID: 10427120.
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    90. Multani AS, Pathak S. Conventional cytogenetics alone is not sufficient for identifying interspecies cell line contamination. Anticancer Res. 1999 May-Jun; 19(3A):1753-4. PMID: 10470110.
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    91. Multani AS, Ozen M, Agrawal A, Hopwood VL, von Eschenbach AC, Pathak S. Amplification of the Y chromosome in three murine tumor cell lines transformed in vivo by different human prostate cancers. In Vitro Cell Dev Biol Anim. 1999 Apr; 35(4):236-9. PMID: 10478804.
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    92. Pai SA, Cheung MC, Romsdahl MM, Multani AS, Pathak S. Can genetic instability be studied at the single chromosome level in cancer cells? Evidence from human melanoma cells. Cancer Genet Cytogenet. 1999 Feb; 109(1):51-7. PMID: 9973960.
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    93. Multani AS, Chandra J, Mcconker J, Sen S, Cabral TF, Pathak S. Cell death in paclitaxel-dependent chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats. Oncol Res. 1999; 11(10):455-60. PMID: 10850886.
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    94. Multani AS, Li C, Ozen M, Imam AS, Wallace S, Pathak S. Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity. Oncol Rep. 1999 Jan-Feb; 6(1):39-44. PMID: 9864398.
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    95. Pathak S, Nemeth MA, Multani AS. Human tumor xenografts in nude mice are not always of human origin: a warning signal. Cancer. 1998 Nov 01; 83(9):1891-3. PMID: 9806646.
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    96. Multani AS, Furlong C, Pathak S. Reduction of telomeric signals in murine melanoma and human breast cancer cell lines treated with 3'-azido-2'-3'-dideoxythymidine. Int J Oncol. 1998 Nov; 13(5):923-5. PMID: 9772280.
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    97. Ozen M, Navone NM, Multani AS, Troncoso P, Logothetis CJ, Chung LW, von Eschenbach AC, Pathak S. Structural alterations of chromosome 5 in twelve human prostate cancer cell lines. Cancer Genet Cytogenet. 1998 Oct 15; 106(2):105-9. PMID: 9797773.
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    98. Ozen M, Imam SA, Datar RH, Multani AS, Narayanan R, Chung LW, von Eschenbach AC, Pathak S. Telomeric DNA: marker for human prostate cancer development? Prostate. 1998 Sep 01; 36(4):264-71. PMID: 9719027.
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    99. Mukhopadhyay T, Multani AS, Roth JA, Pathak S. Reduced telomeric signals and increased telomeric associations in human lung cancer cell lines undergoing p53-mediated apoptosis. Oncogene. 1998 Aug 20; 17(7):901-6. PMID: 9780006.
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    100. Büssing A, Multani AS, Pathak S, Pfüller U, Schietzel M. Induction of apoptosis by the N-acetyl-galactosamine-specific toxic lectin from Viscum album L. is associated with a decrease of nuclear p53 and Bcl-2 proteins and induction of telomeric associations. Cancer Lett. 1998 Aug 14; 130(1-2):57-68. PMID: 9751257.
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    101. Pathak S, Multani AS, Ozen M, Richardson MA, Newman RA. Dolastatin-10 induces polyploidy, telomeric associations and apoptosis in a murine melanoma cell line. Oncol Rep. 1998 Mar-Apr; 5(2):373-6. PMID: 9468560.
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    102. Pathak S, Dolhonde JA, Multani AS. Amplification of telomeric DNA and the extent of karyotypic evolution. Cytobios. 1998; 93(374):141-6. PMID: 9779588.
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    103. Multani AS, Li C, Ozen M, Yadav M, Yu DF, Wallace S, Pathak S. Paclitaxel and water-soluble poly (L-glutamic acid)-paclitaxel, induce direct chromosomal abnormalities and cell death in a murine metastatic melanoma cell line. Anticancer Res. 1997 Nov-Dec; 17(6D):4269-74. PMID: 9494519.
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    104. Augenlicht LH, Wadler S, Corner G, Richards C, Ryan L, Multani AS, Pathak S, Benson A, Haller D, Heerdt BG. Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial. Cancer Res. 1997 May 01; 57(9):1769-75. PMID: 9135021.
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    105. Dhaliwal US, Dhawan S, Multani AS. Reflux oesophagitis in acid peptic disease (a fibre-optic endoscopic study). J Indian Med Assoc. 1997 Feb; 95(2):35-6. PMID: 9357238.
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    106. Multani AS, Kacker RK, Pathak S. Are Robertsonian translocations rare in cancers? Cancer Genet Cytogenet. 1997 Feb; 93(2):179-80. PMID: 9078306.
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    107. Ozen M, Multani AS, Kuniyasu H, Chung LW, von Eschenbach AC, Pathak S. Specific histologic and cytogenetic evidence for in vivo malignant transformation of murine host cells by three human prostate cancer cell lines. Oncol Res. 1997; 9(8):433-8. PMID: 9436196.
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    108. Pathak S, Nemeth MA, Multani AS, Thalmann GN, von Eschenbach AC, Chung LW. Can cancer cells transform normal host cells into malignant cells? Br J Cancer. 1997; 76(9):1134-8. PMID: 9365160.
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    109. Multani AS, Hopwood VL, Pathak S. A modified fluorescence in situ hybridization (FISH) technique. Anticancer Res. 1996 Nov-Dec; 16(6B):3435-7. PMID: 9042203.
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    110. Multani AS, Sheth FJ, Shah VC, Chinoy NJ, Pathak S. Three siblings with Harlequin Ichthyosis in an Indian family. Early Hum Dev. 1996 Jul 19; 45(3):229-33. PMID: 8855396.
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    111. Yadav M, Hopwood VL, Multani AS, Mansfield PF, Takahashi Y, McIntyre BW, Udagawa T, Pathak S. Non-random primary and secondary chromosomal abnormalities in human gastric cancers. Anticancer Res. 1996 Jul-Aug; 16(4A):1787-95. PMID: 8712702.
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    112. Ozen M, Multani A, Chang S, Voneschenbach A, Chung L, Pathak S. Establishment of an in vitro cell model system to study human prostate carcinogenesis. Int J Oncol. 1996 May; 8(5):883-8. PMID: 21544441.
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    113. Sheth FJ, Multani AS, Sheth JJ, Radhakrishna U, Shah VC, Chinoy NJ. Incomplete gonadal dysgenesis. Urol Int. 1996; 56(1):57-60. PMID: 8903559.
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    114. Sheth FJ, Multani AS, Shah VC, Chinoy NJ. Fetal malformations caused by amnion rupture. Indian J Pediatr. 1995 May-Jun; 62(3):369-72. PMID: 10829893.
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    115. Sheth FJ, Radhakrishna U, Multani AS, Shah VC, Chinoy NJ. A female with isodicentric X chromosome idic (Xq) associated with ovarian dysgenesis. Indian J Pediatr. 1994 Mar-Apr; 61(2):189-92. PMID: 7927618.
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    116. Radhakrishna U, Multani AS, Solanki JV, Shah VC, Chinoy NJ. Polydactyly: a study of a five generation Indian family. J Med Genet. 1993 Apr; 30(4):296-9. PMID: 8487274.
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    117. Multani AS, Radhakrishna U, Sheth FJ, Shah VC, Chinoy NJ. Translocation t(22;22)(p11.1;q11.1) and NOR studies in a female with a history of repeated fetal loss. Ann Genet. 1992; 35(2):105-9. PMID: 1524406.
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    118. Prognostic significance of equivocal human epidermal growth factor receptor 2 results and clinical utility of alternative chromosome 17 genes in patients with invasive breast cancer. Cancer.
    119. MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. Journal of Pathology. 241:67-79.
    120. Fragility in the 14q21q translocation region. Genetics and Molecular Biology. 25:271-276.
    121. Maternal inheritance of a 10/15 translocation in a female with a history of obstetric problems. Brazilian Journal of Genetics. 19:497-500.
    122. Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. Oncogene.
    123. Ability to generate patient-derived Breast cancer xenografts is enhanced in chemoresistant disease and predicts poor patient outcomes. PLoS One. 10.
    124. Germline telomere length dynamics and mutagen sensitivity studies in a family with acute reactions to sun exposure. Cancer Genomics and Proteomics. 1:199-208.
    125. HnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell. 28:486-499.
    126. Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis. Journal of Experimental Medicine. 213:1723-1740.
    127. Erratum. PLoS One. 11.
    128. Rapid sex identification of chicken by fluorescence in situ hybridization using a W chromosome-specific DNA probe. Asian-Australasian Journal of Animal Sciences. 15:1531-1535.
    129. Telomere dynamics, aging, and cancer. Journal of Anti-Aging Medicine. 5:271-281.
    130. Simulating clinical features of pancreatic cancer in a mouse model with specific genetic alterations in kras and p53. Cancer Biology and Therapy. 4.
    131. Deletion/inversion in the X-chromosome and increased telomeric associations in a female with primary amenorrhea. Brazilian Journal of Genetics. 20:511-516.
    132. Sister chromatid exchanges. Fluoride - Quarterly Reports. 27:215-219.
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