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ZHENG SUN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Endocrinology
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    Collapse Overview 
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    We are interested in epigenomic regulation of metabolism and cognitive functions by physical exercise, diet, and the circadian clock

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    K99DK099443     (SUN, ZHENG)Aug 1, 2013 - Jul 31, 2015
    NIH/NIDDK
    Epigenomic regulation of metabolism in muscle by circadian clock and environment
    Role: Principal Investigator

    R00DK099443     (SUN, ZHENG)Sep 24, 2014 - Aug 31, 2017
    NIH/NIDDK
    Epigenomic regulation of metabolism in muscle by circadian clock and environment
    Role: Principal Investigator

    R01ES027544     (SUN, ZHENG)Mar 1, 2017 - Feb 28, 2022
    NIH/NIEHS
    Gender-Specific Effects of Arsenic in Diabetes
    Role: Principal Investigator

    R21CA215591     (SUN, ZHENG)Sep 1, 2017 - Aug 31, 2019
    NIH/NCI
    De facto Target of Histone Deacetylase Inhibitors
    Role: Principal Investigator

    R01DK111436     (SUN, ZHENG)Sep 1, 2017 - Aug 31, 2021
    NIH/NIDDK
    Epigenomic Remodeling of Metabolism by Exercise through AP-1
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zheng Y, Qu H, Xiong X, Wang Y, Liu X, Zhang L, Liao X, Liao Q, Sun Z, Ouyang Q, Yang G, Zhu Z, Xu J, Zheng H. Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Contributes to Hepatic Steatosis. Hepatology. 2019 Jul; 70(1):84-97. PMID: 30653687.
      View in: PubMed
    2. Song S, Wen Y, Tong H, Loro E, Gong Y, Liu J, Hong S, Li L, Khurana TS, Chu M, Sun Z. The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism. J Mol Cell Biol. 2019 Feb 01; 11(2):133-143. PMID: 30428023.
      View in: PubMed
    3. Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton JEV, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019 02; 22(2):205-217. PMID: 30664766.
      View in: PubMed
    4. Zhu Z, Yue Q, Xie J, Zhang S, He W, Bai S, Tian S, Zhang Y, Xiong M, Sun Z, Huang C, Li Y, Zheng K, Ye L. Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis. Aging (Albany NY). 2019 Jan 13; 11(1):185-208. PMID: 30636722.
      View in: PubMed
    5. Bai S, Fu K, Yin H, Cui Y, Yue Q, Li W, Cheng L, Tan H, Liu X, Guo Y, Zhang Y, Xie J, He W, Wang Y, Feng H, Xin C, Zhang J, Lin M, Shen B, Sun Z, Guo X, Zheng K, Ye L. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes. Development. 2018 07 04; 145(13). PMID: 29866902.
      View in: PubMed
    6. Cui C, Jiang X, Ju W, Wang J, Wang D, Sun Z, Chen M. Atrial remodeling and metabolic dysfunction in idiopathic isolated fibrotic atrial cardiomyopathy. Int J Cardiol. 2018 Aug 15; 265:155-161. PMID: 29706431.
      View in: PubMed
    7. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 04 02; 128(4):1283-1299. PMID: 29480818.
      View in: PubMed
    8. Ding G, Gong Y, Eckel-Mahan KL, Sun Z. Central Circadian Clock Regulates Energy Metabolism. Adv Exp Med Biol. 2018; 1090:79-103. PMID: 30390286.
      View in: PubMed
    9. Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA. The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORa/?. Genes Dev. 2017 06 15; 31(12):1202-1211. PMID: 28747429.
      View in: PubMed
    10. Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang CC, Qian J, Lie N, Lanzillotta C, Rabinowitz JD, Sun Z. Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol Cell Endocrinol. 2018 08 15; 471:22-32. PMID: 28554803.
      View in: PubMed
    11. Xiong M, Zhu Z, Tian S, Zhu R, Bai S, Fu K, Davis JG, Sun Z, Baur JA, Zheng K, Ye L. Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes. FASEB J. 2017 09; 31(9):3934-3949. PMID: 28490482.
      View in: PubMed
    12. Cao R, Sun Z. Intergenerational Effects of Endocrine Disorder on Metabolism. EBioMedicine. 2017 02; 16:18-19. PMID: 28163044.
      View in: PubMed
    13. Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nat Med. 2017 Feb; 23(2):223-234. PMID: 27991918.
      View in: PubMed
    14. Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 2016 12 13; 24(6):863-874. PMID: 27866836.
      View in: PubMed
    15. Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Richard Lu Q. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Dev Cell. 2016 Jun 20; 37(6):582. PMID: 27326936.
      View in: PubMed
    16. Wang C, Wang L, Liu J, Song J, Sun Y, Lin P, Liang K, Liu F, He T, Sun Z, Hou X, Chen L. Irisin modulates the association of interleukin-17A with the presence of non-proliferative diabetic retinopathy in patients with type 2 diabetes. Endocrine. 2016 Aug; 53(2):459-64. PMID: 26940815.
      View in: PubMed
    17. Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA. GENE REGULATION. Discrete functions of nuclear receptor Rev-erba couple metabolism to the clock. Science. 2015 Jun 26; 348(6242):1488-92. PMID: 26044300.
      View in: PubMed
    18. Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042.
      View in: PubMed
    19. Fang B, Everett LJ, Jager J, Briggs E, Armour SM, Feng D, Roy A, Gerhart-Hines Z, Sun Z, Lazar MA. Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. Cell. 2014 Nov 20; 159(5):1140-1152. PMID: 25416951.
      View in: PubMed
    20. Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM. Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Hum Mol Genet. 2014 Jul 15; 23(14):3801-9. PMID: 24565863.
      View in: PubMed
    21. Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA. Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 2013 Dec 26; 52(6):769-82. PMID: 24268577.
      View in: PubMed
    22. Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD. USP15 negatively regulates Nrf2 through deubiquitination of Keap1. Mol Cell. 2013 Jul 11; 51(1):68-79. PMID: 23727018.
      View in: PubMed
    23. You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA. Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo. Nat Struct Mol Biol. 2013 Feb; 20(2):182-7. PMID: 23292142.
      View in: PubMed
    24. Sun Z, Lazar MA. Dissociating fatty liver and diabetes. Trends Endocrinol Metab. 2013 Jan; 24(1):4-12. PMID: 23043895.
      View in: PubMed
    25. Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med. 2012 Jun; 18(6):934-42. PMID: 22561686.
      View in: PubMed
    26. Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem. 2011 Sep 23; 286(38):33301-9. PMID: 21808063.
      View in: PubMed
    27. Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 2011 Mar 11; 331(6022):1315-9. PMID: 21393543.
      View in: PubMed
    28. Sun Z, Wu T, Zhao F, Lau A, Birch CM, Zhang DD. KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response. Mol Cell Biol. 2011 May; 31(9):1800-11. PMID: 21383067.
      View in: PubMed
    29. Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chem Biol. 2010 May 28; 17(5):537-47. PMID: 20534351.
      View in: PubMed
    30. Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010 Jul; 30(13):3275-85. PMID: 20421418.
      View in: PubMed
    31. Villeneuve NF, Sun Z, Chen W, Zhang DD. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle. 2009 Oct 15; 8(20):3255-6. PMID: 19806015.
      View in: PubMed
    32. Sun Z, Huang Z, Zhang DD. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One. 2009 Aug 11; 4(8):e6588. PMID: 19668370.
      View in: PubMed
    33. Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, Zhang DD. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell. 2009 Jun 26; 34(6):663-73. PMID: 19560419.
      View in: PubMed
    34. Sun Z, Chin YE, Zhang DD. Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol. 2009 May; 29(10):2658-72. PMID: 19273602.
      View in: PubMed
    35. Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD. Dual roles of Nrf2 in cancer. Pharmacol Res. 2008 Nov-Dec; 58(5-6):262-70. PMID: 18838122.
      View in: PubMed
    36. Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, Lou H, Wong PK, Zhang DD. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect. 2008 Sep; 116(9):1154-61. PMID: 18795156.
      View in: PubMed
    37. Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. 2008 Aug 15; 45(4):385-95. PMID: 18482591.
      View in: PubMed
    38. Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis. 2008 Jun; 29(6):1235-43. PMID: 18413364.
      View in: PubMed
    39. Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD. Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol. 2008 Aug 01; 230(3):383-9. PMID: 18417180.
      View in: PubMed
    40. Wang XJ, Sun Z, Chen W, Eblin KE, Gandolfi JA, Zhang DD. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol. 2007 Dec 01; 225(2):206-13. PMID: 17765279.
      View in: PubMed
    41. Sun Z, Zhang S, Chan JY, Zhang DD. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol. 2007 Sep; 27(18):6334-49. PMID: 17636022.
      View in: PubMed
    42. Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem. 2005 Aug 26; 280(34):30091-9. PMID: 15983046.
      View in: PubMed
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