YONGCHENG SONG

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    R21AI090190     (SONG, YONGCHENG)Jun 1, 2010 - Nov 30, 2012
    NIH/NIAID
    Novel Metallo-beta-lactamase Inhibitors
    Role: Principal Investigator

    R21AI088123     (SONG, YONGCHENG)Jun 18, 2010 - Nov 30, 2012
    NIH/NIAID
    Novel inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR)
    Role: Principal Investigator

    R01NS080963     (SONG, YONGCHENG)Sep 30, 2012 - Aug 31, 2017
    NIH/NINDS
    Chemical Probes Targeting Gliomas with IDH Mutation
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li X, Song Y. Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy. J Hematol Oncol. 2020 05 13; 13(1):50. PMID: 32404196.
      Citations:    Fields:    
    2. Gao Y, Chen L, Han Y, Wu F, Yang WS, Zhang Z, Huo T, Zhu Y, Yu C, Kim H, Lee M, Tang Z, Phillips K, He B, Jung SY, Song Y, Zhu B, Xu RM, Feng Q. Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. Commun Biol. 2020 Apr 07; 3(1):165. PMID: 32265480.
      Citations:    
    3. Wu F, Song T, Yao Y, Song Y. Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1. PLoS One. 2019; 14(5):e0216203. PMID: 31048839.
      Citations:    Fields:    Translation:HumansCells
    4. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2019 02 22; 10(16):1603. PMID: 30899429.
      Citations:    Fields:    
    5. Conley ZC, Carlson-Banning KM, Carter AG, de la Cova A, Song Y, Zechiedrich L. Sugar and iron: Toward understanding the antibacterial effect of ciclopirox in Escherichia coli. PLoS One. 2019; 14(1):e0210547. PMID: 30633761.
      Citations: 1     Fields:    Translation:Cells
    6. Lu L, Wen Y, Yao Y, Chen F, Wang G, Wu F, Wu J, Narayanan P, Redell M, Mo Q, Song Y. Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics. 2018; 8(8):2189-2201. PMID: 29721072.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Wu F, Cheng G, Yao Y, Kogiso M, Jiang H, Li XN, Song Y. Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer. Med Chem. 2018; 14(7):715-724. PMID: 29792149.
      Citations: 2     Fields:    Translation:HumansCells
    8. Zhou C, Wu F, Lu L, Wei L, Pai E, Yao Y, Song Y. Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1. PLoS One. 2017; 12(2):e0170301. PMID: 28158205.
      Citations: 2     Fields:    Translation:HumansCells
    9. Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 08 18; 128(7):971-81. PMID: 27335278.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    10. Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL. Antiviral targets of human noroviruses. Curr Opin Virol. 2016 06; 18:117-25. PMID: 27318434.
      Citations: 11     Fields:    Translation:HumansCells
    11. Song Y, Wu F, Wu J. Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives. J Hematol Oncol. 2016 06 17; 9(1):49. PMID: 27316347.
      Citations: 34     Fields:    Translation:Cells
    12. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 03; 7(18):26307-30. PMID: 27027445.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    13. Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol. 2016 Mar 12; 9:24. PMID: 26970896.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    14. Wu F, Zhou C, Yao Y, Wei L, Feng Z, Deng L, Song Y. 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2016 Jan 14; 59(1):253-263. PMID: 26652247.
      Citations: 10     Fields:    Translation:HumansCells
    15. Wu F, Jiang H, Zheng B, Kogiso M, Yao Y, Zhou C, Li XN, Song Y. Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J Med Chem. 2015 Sep 10; 58(17):6899-6908. PMID: 26280302.
      Citations: 12     Fields:    Translation:HumansCells
    16. Chowdhury P, Lin GE, Liu K, Song Y, Lin FT, Lin WC. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014 Nov 17; 5:5476. PMID: 25400145.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    17. Zhang L, Deng L, Chen F, Yao Y, Wu B, Wei L, Mo Q, Song Y. Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget. 2014 Nov 15; 5(21):10665-77. PMID: 25359765.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    18. Liu Z, Yao Y, Kogiso M, Zheng B, Deng L, Qiu JJ, Dong S, Lv H, Gallo JM, Li XN, Song Y. Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. J Med Chem. 2014 Oct 23; 57(20):8307-18. PMID: 25271760.
      Citations: 14     Fields:    Translation:HumansAnimals
    19. Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BW. An epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Res. 2014 Jul; 24(7):809-19. PMID: 24874954.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    20. Liu W, Deng L, Song Y, Redell M. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. PLoS One. 2014; 9(5):e98270. PMID: 24858818.
      Citations: 25     Fields:    Translation:HumansCells
    21. Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors. Medchemcomm. 2013 Oct; 4(10). PMID: 24244836.
      Citations:    
    22. Anglin JL, Song Y. A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L. J Med Chem. 2013 Nov 27; 56(22):8972-83. PMID: 23879463.
      Citations: 17     Fields:    Translation:HumansAnimals
    23. Carlson-Banning KM, Chou A, Liu Z, Hamill RJ, Song Y, Zechiedrich L. Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. PLoS One. 2013; 8(7):e69646. PMID: 23936064.
      Citations: 13     Fields:    Translation:HumansCells
    24. Zheng B, Yao Y, Liu Z, Deng L, Anglin JL, Jiang H, Prasad BV, Song Y. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett. 2013 Jun 13; 4(6):542-546. PMID: 23795241.
      Citations:    
    25. Deng L, Zhang L, Yao Y, Wang C, Redell MS, Dong S, Song Y. Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. Medchemcomm. 2013 May 01; 4(5):822-826. PMID: 23795283.
      Citations:    
    26. Xue J, Diao J, Cai G, Deng L, Zheng B, Yao Y, Song Y. Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase. ACS Med Chem Lett. 2013 Feb 14; 4(2):278-282. PMID: 23795240.
      Citations:    
    27. Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92. PMID: 23365454.
      Citations: 23     Fields:    Translation:Cells
    28. Cai G, Deng L, Xue J, Moreno SN, Striepen B, Song Y. Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2158-61. PMID: 23428849.
      Citations: 2     Fields:    Translation:AnimalsCells
    29. Anglin JL, Deng L, Yao Y, Cai G, Liu Z, Jiang H, Cheng G, Chen P, Dong S, Song Y. Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L. J Med Chem. 2012 Sep 27; 55(18):8066-74. PMID: 22924785.
      Citations: 29     Fields:    Translation:HumansCells
    30. Chen P, Horton LB, Mikulski RL, Deng L, Sundriyal S, Palzkill T, Song Y. 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6229-32. PMID: 22921080.
      Citations: 7     Fields:    Translation:Cells
    31. Cai G, Deng L, Fryszczyn BG, Brown NG, Liu Z, Jiang H, Palzkill T, Song Y. Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS Med Chem Lett. 2012 Jun 14; 3(6):496-500. PMID: 23050057.
      Citations:    
    32. Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y. Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies. J Am Chem Soc. 2011 Oct 26; 133(42):16746-9. PMID: 21936531.
      Citations: 65     Fields:    Translation:HumansCells
    33. Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y. Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies. J Med Chem. 2011 Jul 14; 54(13):4721-34. PMID: 21561155.
      Citations: 14     Fields:    Translation:Cells
    34. Deng L, Endo K, Kato M, Cheng G, Yajima S, Song Y. Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. ACS Med Chem Lett. 2011 Feb 10; 2(2):165-170. PMID: 21379374.
      Citations:    
    35. Deng L, Sundriyal S, Rubio V, Shi ZZ, Song Y. Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J Med Chem. 2009 Nov 12; 52(21):6539-42. PMID: 19888756.
      Citations: 19     Fields:    Translation:HumansCells
    36. Feng Q, He B, Jung SY, Song Y, Qin J, Tsai SY, Tsai MJ, O'Malley BW. Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem. 2009 Dec 25; 284(52):36167-74. PMID: 19843527.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
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