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XINCHUN PI

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Athero & Lipoproteins
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics


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    R01HL061656     (PI, XINCHUN)Jul 1, 1999 - Jan 31, 2018
    NIH/NHLBI
    Signaling in endothelial growth & angiogenesis
    Role: Principal Investigator

    R01HL112890     (PI, XINCHUN)Aug 1, 2013 - Jun 30, 2018
    NIH/NHLBI
    LRP1 and endothelial function
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 Jul 30; 140(5):440-442. PMID: 31356139.
      View in: PubMed
    2. Dyer L, Lockyer P, Wu Y, Saha A, Cyr C, Moser M, Pi X, Patterson C. Correction: BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions. PLoS One. 2018; 13(11):e0207504. PMID: 30496196.
      View in: PubMed
    3. Fan Q, Mao H, Xie L, Pi X. Prolyl Hydroxylase Domain-2 Protein Regulates Lipopolysaccharide-Induced Vascular Inflammation. Am J Pathol. 2019 Jan; 189(1):200-213. PMID: 30339838.
      View in: PubMed
    4. Pi X, Xie L, Patterson C. Emerging Roles of Vascular Endothelium in Metabolic Homeostasis. Circ Res. 2018 Aug 03; 123(4):477-494. PMID: 30355249.
      View in: PubMed
    5. Angelini A, Pi X, Xie L. Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease. Front Physiol. 2017; 8:1044. PMID: 29311974.
      View in: PubMed
    6. Lockyer P, Mao H, Fan Q, Li L, Yu-Lee LY, Eissa NT, Patterson C, Xie L, Pi X. LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1524-1535. PMID: 28596374.
      View in: PubMed
    7. Mao H, Xie L, Pi X. Low-Density Lipoprotein Receptor-Related Protein-1 Signaling in Angiogenesis. Front Cardiovasc Med. 2017; 4:34. PMID: 28589128.
      View in: PubMed
    8. Mao H, Lockyer P, Li L, Ballantyne CM, Patterson C, Xie L, Pi X. Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPAR?. Nat Commun. 2017 04 10; 8:14960. PMID: 28393867.
      View in: PubMed
    9. Mao H, Lockyer P, Townley-Tilson WH, Xie L, Pi X. LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):350-60. PMID: 26634655.
      View in: PubMed
    10. Gomes AV, Rajasekaran NS, Pi X. Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015; 2015:849095. PMID: 26523200.
      View in: PubMed
    11. Dyer L, Lockyer P, Wu Y, Saha A, Cyr C, Moser M, Pi X, Patterson C. BMPER Promotes Epithelial-Mesenchymal Transition in the Developing Cardiac Cushions. PLoS One. 2015; 10(9):e0139209. PMID: 26418455.
      View in: PubMed
    12. Townley-Tilson WH, Pi X, Xie L. The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease. Oxid Med Cell Longev. 2015; 2015:676893. PMID: 26491535.
      View in: PubMed
    13. Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C. PHD2/3-dependent hydroxylation tunes cardiac response to ß-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71. PMID: 26075818.
      View in: PubMed
    14. Xie L, Pi X, Wang Z, He J, Willis MS, Patterson C. Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis. J Mol Cell Cardiol. 2015 Mar; 80:156-65. PMID: 25633836.
      View in: PubMed
    15. Cai Y, Nagel DJ, Zhou Q, Cygnar KD, Zhao H, Li F, Pi X, Knight PA, Yan C. Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia. Circ Res. 2015 Mar 27; 116(7):1120-32. PMID: 25608528.
      View in: PubMed
    16. Dyer L, Pi X, Patterson C. Connecting the coronaries: how the coronary plexus develops and is functionalized. Dev Biol. 2014 Nov 01; 395(1):111-9. PMID: 25173872.
      View in: PubMed
    17. Pi X, Xie L, Portbury AL, Kumar S, Lockyer P, Li X, Patterson C. NADPH oxidase-generated reactive oxygen species are required for stromal cell-derived factor-1a-stimulated angiogenesis. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):2023-32. PMID: 24990230.
      View in: PubMed
    18. Dyer LA, Pi X, Patterson C. The role of BMPs in endothelial cell function and dysfunction. Trends Endocrinol Metab. 2014 Sep; 25(9):472-80. PMID: 24908616.
      View in: PubMed
    19. Xie L, Pi X, Mishra A, Fong G, Peng J, Patterson C. PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. J Clin Invest. 2012 Aug; 122(8):2827-36. PMID: 22797300.
      View in: PubMed
    20. Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ, Jin SW, Patterson C. LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Circ Res. 2012 Aug 17; 111(5):564-74. PMID: 22777006.
      View in: PubMed
    21. Pi X, Lockyer P, Dyer LA, Schisler JC, Russell B, Carey S, Sweet DT, Chen Z, Tzima E, Willis MS, Homeister JW, Moser M, Patterson C. Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2214-22. PMID: 22772758.
      View in: PubMed
    22. Bode M, Wu Y, Pi X, Lockyer P, Dechyapirom W, Portbury AL, Patterson C. Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen. Cell Biochem Funct. 2011 Jun; 29(4):334-41. PMID: 21506136.
      View in: PubMed
    23. Aitsebaomo J, Srivastava S, Zhang H, Jha S, Wang Z, Winnik S, Veleva AN, Pi X, Lockyer P, Faber JE, Patterson C. Recombinant human interleukin-11 treatment enhances collateral vessel growth after femoral artery ligation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):306-12. PMID: 21071685.
      View in: PubMed
    24. Pi X, Wu Y, Ferguson JE, Portbury AL, Patterson C. SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5675-80. PMID: 19307591.
      View in: PubMed
    25. Kelley R, Ren R, Pi X, Wu Y, Moreno I, Willis M, Moser M, Ross M, Podkowa M, Attisano L, Patterson C. A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling. J Cell Biol. 2009 Feb 23; 184(4):597-609. PMID: 19221194.
      View in: PubMed
    26. Pi X, Ren R, Kelley R, Zhang C, Moser M, Bohil AB, Divito M, Cheney RE, Patterson C. Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors. J Cell Biol. 2007 Dec 31; 179(7):1569-82. PMID: 18158328.
      View in: PubMed
    27. Pi X, Patterson C. Twin layers of lightning: a new role for the chaperone Hsp90 in angiogenesis. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):6-7. PMID: 17975116.
      View in: PubMed
    28. Wang H, Charles PC, Wu Y, Ren R, Pi X, Moser M, Barshishat-Kupper M, Rubin JS, Perou C, Bautch V, Patterson C. Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. Circ Res. 2006 May 26; 98(10):1331-9. PMID: 16601226.
      View in: PubMed
    29. Pi X, Garin G, Xie L, Zheng Q, Wei H, Abe J, Yan C, Berk BC. BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha. Circ Res. 2005 Jun 10; 96(11):1145-51. PMID: 15879308.
      View in: PubMed
    30. Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C. Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling. J Mol Cell Cardiol. 2005 Jan; 38(1):175-84. PMID: 15623434.
      View in: PubMed
    31. Pi X, Yan C, Berk BC. Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ Res. 2004 Feb 20; 94(3):362-9. PMID: 14670836.
      View in: PubMed
    32. Pi X, Yan C, Kim D, Chen J, Berk BC. Differential expression of genes from nitrate-tolerant rat aorta. J Vasc Res. 2002 Jul-Aug; 39(4):304-10. PMID: 12187120.
      View in: PubMed
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