WILLIAM MITCH

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    R01AM037175     (MITCH, WILLIAM EVANS)Sep 1, 1985 - Aug 31, 1988
    NIH/NIADDK
    PROTEIN NUTRITION IN EXPERIMENTAL UREMIA
    Role: Principal Investigator

    U01DK039488     (MITCH, WILLIAM EVANS)Sep 30, 1988 - Sep 30, 1994
    NIH/NIDDK
    MODIFICATION OF DIET IN RENAL DISEASE STUDY
    Role: Principal Investigator

    R29HL045317     (MITCH, WILLIAM EVANS)Jul 1, 1990 - Jun 30, 1995
    NIH/NHLBI
    INSULIN LIKE GROWTH FACTOR I ACTION IN HRT &BLD VESSELS
    Role: Principal Investigator

    R01HL045317     (MITCH, WILLIAM EVANS)Jul 1, 1990 - Jul 31, 1999
    NIH/NHLBI
    IGF I ACTION IN HEART AND BLOOD VESSELS
    Role: Principal Investigator

    T32DK007656     (SANDS, JEFF M.)Jul 1, 1990 - Jun 30, 2021
    NIH/NIDDK
    Nephrology Institutional Training Grant
    Role: Co-Principal Investigator

    R01DK040907     (MITCH, WILLIAM EVANS)Sep 1, 1990 - Jun 30, 2000
    NIH/NIDDK
    IMPACT OF RENAL DISEASE ON NITROGEN HOMEOSTASIS
    Role: Principal Investigator

    R01HL047035     (BERNSTEIN, KENNETH E)Aug 1, 1991 - Mar 31, 2000
    NIH/NHLBI
    IGF I AND ITS RECEPTOR AND VASCULAR GROWTH
    Role: Co-Principal Investigator

    P50DK045215     (MITCH, WILLIAM EVANS)Jul 1, 1992 - Jun 30, 1998
    NIH/NIDDK
    CHRONIC RENAL FAILURE--PATHOGENESIS AND TREATMENT
    Role: Principal Investigator

    P50DK064233     (MITCH, WILLIAM EVANS)May 1, 2003 - Apr 30, 2010
    NIH/NIDDK
    Renal Inflammation: Mechanisms and Consequences
    Role: Principal Investigator

    T32DK062706     (MITCH, WILLIAM EVANS)Jul 1, 2003 - Jun 30, 2014
    NIH/NIDDK
    Research Training in Renal Diseases
    Role: Principal Investigator

    R01DK062828     (MITCH, WILLIAM EVANS)May 1, 2005 - Mar 31, 2010
    NIH/NIDDK
    SMAD SIGNALING IN ANGIOTENSIN II-MEDIATED RENAL FIBROSIS
    Role: Principal Investigator

    R37DK037175     (MITCH, WILLIAM EVANS)Jan 26, 2010 - Nov 30, 2010
    NIH/NIDDK
    Protein Nutrition in Experimental Uremia
    Role: Principal Investigator

    R01DK037175     (MITCH, WILLIAM EVANS)May 2, 2018 - Nov 30, 2005
    NIH/NIDDK
    Protein Nutrition in Experimental Uremia
    Role: Principal Investigator

    R01DK124259     (CHENG, JIZHONG)Apr 1, 2020 - Mar 31, 2024
    NIH/NIDDK
    Interplay between skeletal muscle catabolism and remodeling of arteriovenous fistulae via YAP1/TAZ signaling
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Song K, Qing Y, Guo Q, Peden EK, Chen C, Mitch WE, Truong L, Cheng J. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease. JCI Insight. 2020 Nov 05; 5(21). PMID: 33001865.
      Citations:    Fields:    
    2. Guo Q, Huang F, Qing Y, Feng S, Xiao X, Wang Y, Liang M, Wang T, Mitch WE, Cheng J. Decreased Jagged1 expression in vascular smooth muscle cells delays endothelial regeneration in arteriovenous graft. Cardiovasc Res. 2020 Nov 01; 116(13):2142-2155. PMID: 31913453.
      Citations:    Fields:    
    3. An C, Wen J, Hu Z, Mitch WE, Wang Y. Phosphoinositide 3-kinase ? deficiency attenuates kidney injury and fibrosis in angiotensin II-induced hypertension. Nephrol Dial Transplant. 2020 09 01; 35(9):1491-1500. PMID: 32500132.
      Citations:    Fields:    
    4. Zhang L, Chen Q, Chen Z, Wang Y, Gamboa JL, Ikizler TA, Garibotto G, Mitch WE. Mechanisms Regulating Muscle Protein Synthesis in CKD. J Am Soc Nephrol. 2020 Nov; 31(11):2573-2587. PMID: 32764136.
      Citations:    Fields:    
    5. Le N, Moore LW, Fong JVN, Doan T, Mitch WE, Workeneh B, Moore CE. Healthy Eating Index of Living Donor Renal Transplantation Recipients During the First Year Posttransplant. Prog Transplant. 2020 09; 30(3):271-277. PMID: 32677538.
      Citations:    Fields:    
    6. Zhang L, Wang Y, Dong Y, Chen Z, Eckols TK, Kasembeli MM, Tweardy DJ, Mitch WE. Pharmacokinetics and pharmacodynamics of TTI-101, a STAT3 inhibitor that blocks muscle proteolysis in rats with chronic kidney disease. Am J Physiol Renal Physiol. 2020 07 01; 319(1):F84-F92. PMID: 32475130.
      Citations:    Fields:    Translation:AnimalsCells
    7. Zhang L, Chen Z, Wang Y, Tweardy DJ, Mitch WE. Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E625-E635. PMID: 32101031.
      Citations:    Fields:    Translation:AnimalsCells
    8. Melamed ML, Horwitz EJ, Dobre MA, Abramowitz MK, Zhang L, Lo Y, Mitch WE, Hostetter TH. Effects of Sodium Bicarbonate in CKD Stages 3 and 4: A Randomized, Placebo-Controlled, Multicenter Clinical Trial. Am J Kidney Dis. 2020 02; 75(2):225-234. PMID: 31699517.
      Citations: 1     Fields:    Translation:Humans
    9. Wu J, Dong J, Verzola D, Hruska K, Garibotto G, Hu Z, Mitch WE, Thomas SS. Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk. J Cachexia Sarcopenia Muscle. 2019 12; 10(6):1210-1227. PMID: 31507080.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Workeneh B, Moore LW, Nolte Fong JV, Shypailo R, Gaber AO, Mitch WE. Successful Kidney Transplantation Is Associated With Weight Gain From Truncal Obesity and Insulin Resistance. J Ren Nutr. 2019 11; 29(6):548-555. PMID: 30852120.
      Citations: 1     Fields:    Translation:Humans
    11. Liang M, Guo Q, Huang F, Han G, Song K, Luo J, Cheng H, Hu H, Peden EK, Chen C, Mitch WE, Du J, Fu X, Truong L, Cheng J. Notch signaling in bone marrow-derived FSP-1 cells initiates neointima formation in arteriovenous fistulas. Kidney Int. 2019 06; 95(6):1347-1358. PMID: 30799025.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Vangala C, Niu J, Lenihan CR, Mitch WE, Navaneethan SD, Winkelmayer WC. Proton Pump Inhibitors, Histamine-2 Receptor Antagonists, and Hip Fracture Risk among Patients on Hemodialysis. Clin J Am Soc Nephrol. 2018 10 08; 13(10):1534-1541. PMID: 30262672.
      Citations: 3     Fields:    Translation:Humans
    13. Mindikoglu AL, Opekun AR, Mitch WE, Magder LS, Christenson RH, Dowling TC, Weir MR, Seliger SL, Howell CD, Raufman JP, Rana A, Goss JA, Khaderi SA, Vierling JM. Cystatin C Is a Gender-Neutral Glomerular Filtration Rate Biomarker in Patients with Cirrhosis. Dig Dis Sci. 2018 03; 63(3):665-675. PMID: 29392554.
      Citations: 5     Fields:    Translation:Humans
    14. Deger SM, Hung AM, Gamboa JL, Siew ED, Ellis CD, Booker C, Sha F, Li H, Bian A, Stewart TG, Zent R, Mitch WE, Abumrad NN, Ikizler TA. Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients. JCI Insight. 2017 11 16; 2(22). PMID: 29202452.
      Citations: 7     Fields:    Translation:HumansAnimals
    15. Peng H, Wang Q, Lou T, Qin J, Jung S, Shetty V, Li F, Wang Y, Feng XH, Mitch WE, Graham BH, Hu Z. Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys. Nat Commun. 2017 11 14; 8(1):1493. PMID: 29138395.
      Citations: 11     Fields:    Translation:Animals
    16. Liang H, Zhang Z, Yan J, Wang Y, Hu Z, Mitch WE, Wang Y. The IL-4 receptor a has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney Int. 2017 12; 92(6):1433-1443. PMID: 28739140.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Wang Y, Jia L, Hu Z, Entman ML, Mitch WE, Wang Y. AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis. Kidney Int. 2018 01; 93(1):81-94. PMID: 28739141.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    18. Thomas SS, Mitch WE. Parathyroid hormone stimulates adipose tissue browning: a pathway to muscle wasting. Curr Opin Clin Nutr Metab Care. 2017 May; 20(3):153-157. PMID: 28257332.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    19. Li J, An C, Kang L, Mitch WE, Wang Y. Recent Advances in Magnetic Resonance Imaging Assessment of Renal Fibrosis. Adv Chronic Kidney Dis. 2017 05; 24(3):150-153. PMID: 28501077.
      Citations: 5     Fields:    Translation:Humans
    20. Dong J, Dong Y, Chen Z, Mitch WE, Zhang L. The pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease. Kidney Int. 2017 01; 91(1):119-128. PMID: 27653838.
      Citations: 10     Fields:    Translation:AnimalsCells
    21. Mitch WE, Remuzzi G. Diets for patients with chronic kidney disease, should we reconsider? BMC Nephrol. 2016 07 11; 17(1):80. PMID: 27401192.
      Citations: 17     Fields:    Translation:Humans
    22. Fouque D, Chen J, Chen W, Garneata L, Hwang SJ, Kalantar-Zadeh K, Kopple JD, Mitch WE, Piccoli G, Teplan V, Chauveau P. Adherence to ketoacids/essential amino acids-supplemented low protein diets and new indications for patients with chronic kidney disease. BMC Nephrol. 2016 07 07; 17(1):63. PMID: 27388899.
      Citations: 8     Fields:    Translation:Humans
    23. Wyatt CM, Mitch WE. In experimental chronic kidney disease or cancer, parathyroid hormone is a novel mediator of cachexia. Kidney Int. 2016 May; 89(5):973-975. PMID: 27083271.
      Citations:    Fields:    Translation:Humans
    24. Thomas SS, Zhang L, Mitch WE. Molecular mechanisms of insulin resistance in chronic kidney disease. Kidney Int. 2015 Dec; 88(6):1233-1239. PMID: 26444029.
      Citations: 13     Fields:    
    25. Dong J, Dong Y, Dong Y, Chen F, Mitch WE, Zhang L. Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues. Int J Obes (Lond). 2016 Mar; 40(3):434-442. PMID: 26435323.
      Citations: 32     Fields:    Translation:Animals
    26. Workeneh B, Shypailo R, DeCastro I, Shah M, Guffey D, Minard CG, Mitch WE. Adverse Effects of Sporadic Dialysis on Body Composition. Nephron. 2015; 131(1):73-7. PMID: 26314556.
      Citations:    Fields:    Translation:Humans
    27. Peng H, Cao J, Yu R, Danesh F, Wang Y, Mitch WE, Xu J, Hu Z. CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation. J Am Soc Nephrol. 2016 Feb; 27(2):509-19. PMID: 26054539.
      Citations: 8     Fields:    Translation:Animals
    28. Yan J, Zhang Z, Yang J, Mitch WE, Wang Y. JAK3/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis. J Am Soc Nephrol. 2015 Dec; 26(12):3060-71. PMID: 26032813.
      Citations: 24     Fields:    Translation:AnimalsCells
    29. Workeneh B, Guffey D, Minard CG, Mitch WE. Causes for Withdrawal in an Urban Peritoneal Dialysis Program. Int J Nephrol. 2015; 2015:652953. PMID: 26064683.
      Citations:    
    30. Silva KA, Dong J, Dong Y, Dong Y, Schor N, Tweardy DJ, Zhang L, Mitch WE. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24; 290(17):11177-87. PMID: 25787076.
      Citations: 40     Fields:    Translation:AnimalsCells
    31. Liang M, Wang Y, Liang A, Mitch WE, Roy-Chaudhury P, Han G, Cheng J. Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima. Kidney Int. 2015 Sep; 88(3):490-502. PMID: 25786100.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    32. Luo J, Liang M, Mitch WE, Danesh FR, Yu M, Cheng J. FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice. Endocrinology. 2015 Jun; 156(6):2200-10. PMID: 25774552.
      Citations:    Fields:    Translation:AnimalsCells
    33. Liang M, Woodard LE, Liang A, Luo J, Wilson MH, Mitch WE, Cheng J. Protective role of insulin-like growth factor-1 receptor in endothelial cells against unilateral ureteral obstruction-induced renal fibrosis. Am J Pathol. 2015 May; 185(5):1234-50. PMID: 25783760.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    34. Ikizler TA, Lovett DH, Chertow GM, Mitch WE, Schiller B. Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology. Am J Kidney Dis. 2015 Mar; 65(3):381-3. PMID: 25542413.
      Citations: 1     Fields:    Translation:Humans
    35. Fouque D, Mitch WE. Low-protein diets in chronic kidney disease: are we finally reaching a consensus? Nephrol Dial Transplant. 2015 Jan; 30(1):6-8. PMID: 25358494.
      Citations: 12     Fields:    Translation:Humans
    36. Chu W, Gao N, Yin D, Krasner SW, Mitch WA. Impact of UV/H2O2 pre-oxidation on the formation of haloacetamides and other nitrogenous disinfection byproducts during chlorination. Environ Sci Technol. 2014 Oct 21; 48(20):12190-8. PMID: 25251305.
      Citations: 5     Fields:    Translation:CellsPHPublic Health
    37. Weiner ID, Mitch WE, Sands JM. Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion. Clin J Am Soc Nephrol. 2015 Aug 07; 10(8):1444-58. PMID: 25078422.
      Citations: 51     Fields:    Translation:HumansAnimals
    38. Rondon-Berrios H, Wang Y, Mitch WE. Can muscle-kidney crosstalk slow progression of CKD? J Am Soc Nephrol. 2014 Dec; 25(12):2681-3. PMID: 25012171.
      Citations: 3     Fields:    Translation:Animals
    39. Wang XH, Mitch WE. Mechanisms of muscle wasting in chronic kidney disease. Nat Rev Nephrol. 2014 Sep; 10(9):504-16. PMID: 24981816.
      Citations: 94     Fields:    Translation:HumansCells
    40. Hu Z, Klein JD, Mitch WE, Zhang L, Martinez I, Wang XH. MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways. Aging (Albany NY). 2014 Mar; 6(3):160-75. PMID: 24659628.
      Citations: 29     Fields:    Translation:AnimalsCells
    41. Wang Y, Liang A, Luo J, Liang M, Han G, Mitch WE, Cheng J. Blocking Notch in endothelial cells prevents arteriovenous fistula failure despite CKD. J Am Soc Nephrol. 2014 Apr; 25(4):773-83. PMID: 24480830.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    42. Attaix D, Mitch WE. A dedication to Alfred L. Goldberg. Int J Biochem Cell Biol. 2013 Oct; 45(10):2120. PMID: 24137800.
      Citations:    Fields:    Translation:Humans
    43. Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch W, Teplan V, Yu X, Zakar G. Do ketoanalogues still have a role in delaying dialysis initiation in CKD predialysis patients? Semin Dial. 2013 Nov-Dec; 26(6):714-9. PMID: 24016150.
      Citations: 19     Fields:    Translation:Humans
    44. Zhang L, Pan J, Dong Y, Tweardy DJ, Dong Y, Garibotto G, Mitch WE. Stat3 activation links a C/EBPd to myostatin pathway to stimulate loss of muscle mass. Cell Metab. 2013 Sep 03; 18(3):368-79. PMID: 24011072.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    45. Wang XH, Mitch WE. Muscle wasting from kidney failure-a model for catabolic conditions. Int J Biochem Cell Biol. 2013 Oct; 45(10):2230-8. PMID: 23872437.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    46. Workeneh B, Mitch WE. High-protein diet in diabetic nephropathy: what is really safe? Am J Clin Nutr. 2013 Aug; 98(2):266-8. PMID: 23824718.
      Citations:    Fields:    Translation:Humans
    47. Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S, Delafontaine P. Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia. Int J Biochem Cell Biol. 2013 Oct; 45(10):2322-32. PMID: 23769949.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    48. Han HQ, Zhou X, Mitch WE, Goldberg AL. Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. Int J Biochem Cell Biol. 2013 Oct; 45(10):2333-47. PMID: 23721881.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    49. Thomas SS, Dong Y, Zhang L, Mitch WE. Signal regulatory protein-a interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease. Kidney Int. 2013 Aug; 84(2):308-16. PMID: 23515050.
      Citations: 20     Fields:    Translation:AnimalsCells
    50. Carrero JJ, Stenvinkel P, Cuppari L, Ikizler TA, Kalantar-Zadeh K, Kaysen G, Mitch WE, Price SR, Wanner C, Wang AY, ter Wee P, Franch HA. Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013 Mar; 23(2):77-90. PMID: 23428357.
      Citations: 107     Fields:    Translation:Humans
    51. Moore LW, Byham-Gray LD, Scott Parrott J, Rigassio-Radler D, Mandayam S, Jones SL, Mitch WE, Osama Gaber A. The mean dietary protein intake at different stages of chronic kidney disease is higher than current guidelines. Kidney Int. 2013 Apr; 83(4):724-32. PMID: 23302719.
      Citations: 14     Fields:    Translation:Humans
    52. Thomas SS, Mitch WE. Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin. Clin Exp Nephrol. 2013 Apr; 17(2):174-82. PMID: 23292175.
      Citations: 14     Fields:    Translation:Humans
    53. Huang H, Wu QY, Hu HY, Mitch WA. Dichloroacetonitrile and dichloroacetamide can form independently during chlorination and chloramination of drinking waters, model organic matters, and wastewater effluents. Environ Sci Technol. 2012 Oct 02; 46(19):10624-31. PMID: 22950789.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    54. Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J. Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. J Pathol. 2012 Dec; 228(4):448-58. PMID: 22711583.
      Citations: 12     Fields:    Translation:AnimalsCells
    55. Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X. Keto acid therapy in predialysis chronic kidney disease patients: final consensus. J Ren Nutr. 2012 Mar; 22(2 Suppl):S22-4. PMID: 22365372.
      Citations: 24     Fields:    Translation:Humans
    56. Aparicio M, Bellizzi V, Chauveau P, Cupisti A, Ecder T, Fouque D, Garneata L, Lin S, Mitch WE, Teplan V, Zakar G, Yu X. Protein-restricted diets plus keto/amino acids--a valid therapeutic approach for chronic kidney disease patients. J Ren Nutr. 2012 Mar; 22(2 Suppl):S1-21. PMID: 22365371.
      Citations: 17     Fields:    Translation:HumansAnimals
    57. Han HQ, Mitch WE. Targeting the myostatin signaling pathway to treat muscle wasting diseases. Curr Opin Support Palliat Care. 2011 Dec; 5(4):334-41. PMID: 22025090.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    58. Erez A, Nagamani SC, Shchelochkov OA, Premkumar MH, Campeau PM, Chen Y, Garg HK, Li L, Mian A, Bertin TK, Black JO, Zeng H, Tang Y, Reddy AK, Summar M, O'Brien WE, Harrison DG, Mitch WE, Marini JC, Aschner JL, Bryan NS, Lee B. Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Nov 13; 17(12):1619-26. PMID: 22081021.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    59. Wang XH, Hu Z, Klein JD, Zhang L, Fang F, Mitch WE. Decreased miR-29 suppresses myogenesis in CKD. J Am Soc Nephrol. 2011 Nov; 22(11):2068-76. PMID: 21965375.
      Citations: 37     Fields:    Translation:AnimalsCells
    60. Tabony AM, Yoshida T, Galvez S, Higashi Y, Sukhanov S, Chandrasekar B, Mitch WE, Delafontaine P. Angiotensin II upregulates protein phosphatase 2Ca and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting. Hypertension. 2011 Oct; 58(4):643-9. PMID: 21844485.
      Citations: 21     Fields:    Translation:AnimalsCells
    61. Kopple JD, Cheung AK, Christiansen JS, Djurhuus CB, El Nahas M, Feldt-Rasmussen B, Mitch WE, Wanner C, Göthberg M, Ikizler TA. OPPORTUNITY™: a large-scale randomized clinical trial of growth hormone in hemodialysis patients. Nephrol Dial Transplant. 2011 Dec; 26(12):4095-103. PMID: 21750157.
      Citations: 11     Fields:    Translation:Humans
    62. Wang Y, Mitch WE. Proteins and renal fibrosis: low-protein diets induce Kruppel-like factor-15, limiting renal fibrosis. Kidney Int. 2011 May; 79(9):933-4. PMID: 21490612.
      Citations: 4     Fields:    Translation:Animals
    63. Lecker SH, Mitch WE. Proteolysis by the ubiquitin-proteasome system and kidney disease. J Am Soc Nephrol. 2011 May; 22(5):821-4. PMID: 21474563.
      Citations: 12     Fields:    Translation:HumansAnimals
    64. Zhang L, Rajan V, Lin E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch WE. Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. FASEB J. 2011 May; 25(5):1653-63. PMID: 21282204.
      Citations: 91     Fields:    Translation:AnimalsCells
    65. Wang XH, Zhang L, Mitch WE, LeDoux JM, Hu J, Du J. Caspase-3 cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity. J Biol Chem. 2010 Jul 09; 285(28):21249-57. PMID: 20424172.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    66. Hu Z, Wang H, Lee IH, Modi S, Wang X, Du J, Mitch WE. PTEN inhibition improves muscle regeneration in mice fed a high-fat diet. Diabetes. 2010 Jun; 59(6):1312-20. PMID: 20200318.
      Citations: 43     Fields:    Translation:AnimalsCells
    67. Workeneh BT, Mitch WE. Review of muscle wasting associated with chronic kidney disease. Am J Clin Nutr. 2010 Apr; 91(4):1128S-1132S. PMID: 20181807.
      Citations: 76     Fields:    Translation:Humans
    68. Zhang L, Wang XH, Wang H, Du J, Mitch WE. Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy. J Am Soc Nephrol. 2010 Mar; 21(3):419-27. PMID: 20056750.
      Citations: 65     Fields:    Translation:AnimalsCells
    69. Zhang L, Ran L, Garcia GE, Wang XH, Han S, Du J, Mitch WE. Chemokine CXCL16 regulates neutrophil and macrophage infiltration into injured muscle, promoting muscle regeneration. Am J Pathol. 2009 Dec; 175(6):2518-27. PMID: 19893053.
      Citations: 40     Fields:    Translation:AnimalsCells
    70. Hu Z, Wang H, Lee IH, Du J, Mitch WE. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest. 2009 Oct; 119(10):3059-69. PMID: 19759515.
      Citations: 67     Fields:    Translation:AnimalsCells
    71. Wang XH, Du J, Klein JD, Bailey JL, Mitch WE. Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function. Kidney Int. 2009 Oct; 76(7):751-9. PMID: 19641484.
      Citations: 38     Fields:    Translation:AnimalsCells
    72. Leal VO, Delgado AG, Leite M, Mitch WE, Mafra D. Influence of renal function and diet on acid-base status in chronic kidney disease patients. J Ren Nutr. 2009 Mar; 19(2):178-82. PMID: 19218046.
      Citations: 4     Fields:    Translation:Humans
    73. Zhang L, Du J, Hu Z, Han G, Delafontaine P, Garcia G, Mitch WE. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol. 2009 Mar; 20(3):604-12. PMID: 19158350.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    74. Franch HA, Mitch WE. Navigating between the Scylla and Charybdis of prescribing dietary protein for chronic kidney diseases. Annu Rev Nutr. 2009; 29:341-64. PMID: 19575595.
      Citations: 6     Fields:    Translation:Humans
    75. Kopple JD, Cheung AK, Christiansen JS, Djurhuus CB, El Nahas M, Feldt-Rasmussen B, Lange M, Mitch WE, Wanner C, Wiedemann J, Ikizler TA. OPPORTUNITY: a randomized clinical trial of growth hormone on outcome in hemodialysis patients. Clin J Am Soc Nephrol. 2008 Nov; 3(6):1741-51. PMID: 18945992.
      Citations: 7     Fields:    Translation:Humans
    76. Rajan V, Mitch WE. Ubiquitin, proteasomes and proteolytic mechanisms activated by kidney disease. Biochim Biophys Acta. 2008 Dec; 1782(12):795-9. PMID: 18723090.
      Citations: 14     Fields:    Translation:HumansAnimals
    77. Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Treviño-Becerra A, Trevinho-Becerra A, Wanner C. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int. 2008 Feb; 73(4):391-8. PMID: 18094682.
      Citations: 313     Fields:    Translation:Humans
    78. Deboer MD, Zhu X, Levasseur PR, Inui A, Hu Z, Han G, Mitch WE, Taylor JE, Halem HA, Dong JZ, Datta R, Culler MD, Marks DL. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Endocrinology. 2008 Feb; 149(2):827-35. PMID: 18039782.
      Citations: 48     Fields:    Translation:Animals
    79. Rajan VR, Mitch WE. Muscle wasting in chronic kidney disease: the role of the ubiquitin proteasome system and its clinical impact. Pediatr Nephrol. 2008 Apr; 23(4):527-35. PMID: 17987322.
      Citations: 16     Fields:    Translation:Humans
    80. Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes. 2007 Oct; 56(10):2449-56. PMID: 17623817.
      Citations: 26     Fields:    Translation:AnimalsCells
    81. Mitch WE. Malnutrition is an unusual cause of decreased muscle mass in chronic kidney disease. J Ren Nutr. 2007 Jan; 17(1):66-9. PMID: 17198936.
      Citations: 7     Fields:    Translation:HumansAnimals
    82. Kaysen GA, Levin NW, Mitch WE, Chapman AL, Kubala L, Eiserich JP. Evidence that C-reactive protein or IL-6 are not surrogates for all inflammatory cardiovascular risk factors in hemodialysis patients. Blood Purif. 2006; 24(5-6):508-16. PMID: 17077623.
      Citations: 4     Fields:    Translation:Humans
    83. Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE. Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions. J Am Soc Nephrol. 2006 Nov; 17(11):3233-9. PMID: 17005936.
      Citations: 28     Fields:    Translation:Humans
    84. Marinovic AC, Zheng B, Mitch WE, Price SR. Tissue-specific regulation of ubiquitin (UbC) transcription by glucocorticoids: in vivo and in vitro analyses. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F660-6. PMID: 16954342.
      Citations: 9     Fields:    Translation:AnimalsCells
    85. Löfberg E, Gutierrez A, Anderstam B, Wernerman J, Bergström J, Price SR, Mitch WE, Alvestrand A. Effect of bicarbonate on muscle protein in patients receiving hemodialysis. Am J Kidney Dis. 2006 Sep; 48(3):419-29. PMID: 16931215.
      Citations: 11     Fields:    Translation:Humans
    86. Mitch WE. Proteolytic mechanisms, not malnutrition, cause loss of muscle mass in kidney failure. J Ren Nutr. 2006 Jul; 16(3):208-11. PMID: 16825021.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    87. Wang X, Hu Z, Hu J, Du J, Mitch WE. Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006 Sep; 147(9):4160-8. PMID: 16777975.
      Citations: 166     Fields:    Translation:AnimalsCells
    88. Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol. 2006 Jul; 17(7):1807-19. PMID: 16738015.
      Citations: 319     Fields:    Translation:Cells
    89. Keane WF, Zhang Z, Lyle PA, Cooper ME, de Zeeuw D, Grunfeld JP, Lash JP, McGill JB, Mitch WE, Remuzzi G, Shahinfar S, Snapinn SM, Toto R, Brenner BM. Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy: the RENAAL study. Clin J Am Soc Nephrol. 2006 Jul; 1(4):761-7. PMID: 17699284.
      Citations: 66     Fields:    Translation:Humans
    90. Bailey JL, Zheng B, Hu Z, Price SR, Mitch WE. Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy. J Am Soc Nephrol. 2006 May; 17(5):1388-94. PMID: 16611720.
      Citations: 79     Fields:    Translation:AnimalsCells
    91. Mitch WE. Metabolic and clinical consequences of metabolic acidosis. J Nephrol. 2006 Mar-Apr; 19 Suppl 9:S70-5. PMID: 16736444.
      Citations: 18     Fields:    Translation:Humans
    92. Mandayam S, Mitch WE. Dietary protein restriction benefits patients with chronic kidney disease. Nephrology (Carlton). 2006 Feb; 11(1):53-7. PMID: 16509933.
      Citations: 12     Fields:    Translation:Humans
    93. Mandayam S, Mitch WE. Is cystatin C more effective than creatinine in predicting adverse cardiovascular outcomes in elderly people? Nat Clin Pract Nephrol. 2005 Nov; 1(1):8-9. PMID: 16932354.
      Citations:    Fields:    
    94. Du J, Hu Z, Mitch WE. Cellular signals activating muscle proteolysis in chronic kidney disease: a two-stage process. Int J Biochem Cell Biol. 2005 Oct; 37(10):2147-55. PMID: 15982920.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    95. Du J, Mitch WE. Identification of pathways controlling muscle protein metabolism in uremia and other catabolic conditions. Curr Opin Nephrol Hypertens. 2005 Jul; 14(4):378-82. PMID: 15931008.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    96. Mitch WE. Cachexia in chronic kidney disease: a link to defective central nervous system control of appetite. J Clin Invest. 2005 Jun; 115(6):1476-8. PMID: 15931387.
      Citations: 7     Fields:    Translation:HumansAnimals
    97. Li PK, Weening JJ, Dirks J, Lui SL, Szeto CC, Tang S, Atkins RC, Mitch WE, Chow KM, D'Amico G, Freedman BI, Harris DC, Hooi LS, Jong PE, Kincaid-Smith P, Lai KN, Lee E, Li FK, Lin SY, Lo WK, Mani MK, Mathew T, Murakami M, Qian JQ, Ramirez S, Reiser T, Tomino Y, Tong MK, Tsang WK, Tungsanga K, Wang H, Wong AK, Wong KM, Yang WC, de Zeeuw D, Yu AW, Remuzzi G. A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease, Hong Kong, June 29, 2004. Kidney Int Suppl. 2005 Apr; (94):S2-7. PMID: 15752234.
      Citations: 11     Fields:    Translation:HumansPHPublic Health
    98. Mitch WE. Beneficial responses to modified diets in treating patients with chronic kidney disease. Kidney Int Suppl. 2005 Apr; (94):S133-5. PMID: 15752230.
      Citations: 6     Fields:    Translation:Humans
    99. Song YH, Li Y, Du J, Mitch WE, Rosenthal N, Delafontaine P. Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest. 2005 Feb; 115(2):451-8. PMID: 15650772.
      Citations: 115     Fields:    Translation:AnimalsCells
    100. Mitch WE. 2004 Presidential Address: An evaluation of progress toward goals. J Am Soc Nephrol. 2005 Mar; 16(3):576-82. PMID: 15677306.
      Citations:    Fields:    Translation:Humans
    101. Mitch WE, Hu Z, Lee SW, Du J. Strategies for suppressing muscle atrophy in chronic kidney disease: mechanisms activating distinct proteolytic systems. J Ren Nutr. 2005 Jan; 15(1):23-7. PMID: 15648002.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    102. Workeneh B, Balakumaran A, Bichet DG, Mitch WE. The dilemma of diagnosing the cause of hypernatraemia: drinking habits vs diabetes insipidus. Nephrol Dial Transplant. 2004 Dec; 19(12):3165-7. PMID: 15575005.
      Citations: 1     Fields:    Translation:Humans
    103. Ahuja TS, Mitch WE. The evidence against malnutrition as a prominent problem for chronic dialysis patients. Semin Dial. 2004 Nov-Dec; 17(6):427-31. PMID: 15660572.
      Citations: 5     Fields:    Translation:Humans
    104. Ahuja TS, Mitch WE. Protein catabolism in chronic uremia: is it due to malnutrition? Arch Immunol Ther Exp (Warsz). 2004 Sep-Oct; 52(5):326-31. PMID: 15507873.
      Citations:    Fields:    Translation:Humans
    105. Mitch WE, Du J. Cellular mechanisms causing loss of muscle mass in kidney disease. Semin Nephrol. 2004 Sep; 24(5):484-7. PMID: 15490416.
      Citations: 9     Fields:    Translation:Humans
    106. de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, Shahinfar S, Snapinn S, Cooper ME, Mitch WE, Brenner BM. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation. 2004 Aug 24; 110(8):921-7. PMID: 15302780.
      Citations: 168     Fields:    Translation:HumansCTClinical Trials
    107. de Zeeuw D, Remuzzi G, Parving HH, Keane WF, Zhang Z, Shahinfar S, Snapinn S, Cooper ME, Mitch WE, Brenner BM. Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL. Kidney Int. 2004 Jun; 65(6):2309-20. PMID: 15149345.
      Citations: 213     Fields:    Translation:HumansCTClinical Trials
    108. Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE. Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase. J Am Soc Nephrol. 2004 Jun; 15(6):1537-45. PMID: 15153564.
      Citations: 105     Fields:    Translation:AnimalsCells
    109. Kaysen GA, Dubin JA, Müller HG, Rosales L, Levin NW, Mitch WE. Inflammation and reduced albumin synthesis associated with stable decline in serum albumin in hemodialysis patients. Kidney Int. 2004 Apr; 65(4):1408-15. PMID: 15086482.
      Citations: 42     Fields:    Translation:Humans
    110. Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest. 2004 Jan; 113(1):115-23. PMID: 14702115.
      Citations: 198     Fields:    Translation:AnimalsCells
    111. Mitch WE, Remuzzi G. Diets for patients with chronic kidney disease, still worth prescribing. J Am Soc Nephrol. 2004 Jan; 15(1):234-7. PMID: 14694178.
      Citations: 25     Fields:    Translation:Humans
    112. Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, Goldberg AL. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004 Jan; 18(1):39-51. PMID: 14718385.
      Citations: 477     Fields:    Translation:AnimalsCells
    113. Mitch WE. Getting beyond cross-sectional studies of abnormal nutritional indexes in dialysis patients. Am J Clin Nutr. 2003 Apr; 77(4):760-1. PMID: 12663268.
      Citations:    Fields:    Translation:Humans
    114. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest. 2003 Apr; 111(8):1201-9. PMID: 12697739.
      Citations: 440     Fields:    Translation:AnimalsCells
    115. Mitch WE, Price SR. Mechanisms activating proteolysis to cause muscle atrophy in catabolic conditions. J Ren Nutr. 2003 Apr; 13(2):149-52. PMID: 12671840.
      Citations: 7     Fields:    Translation:HumansAnimals
    116. Keane WF, Brenner BM, de Zeeuw D, Grunfeld JP, McGill J, Mitch WE, Ribeiro AB, Shahinfar S, Simpson RL, Snapinn SM, Toto R. The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study. Kidney Int. 2003 Apr; 63(4):1499-507. PMID: 12631367.
      Citations: 96     Fields:    Translation:Humans
    117. Kaysen GA, Dubin JA, Müller HG, Mitch WE, Rosales L, Levin NW. Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients. Kidney Int. 2003 Jan; 63(1):315-22. PMID: 12472798.
      Citations: 3     Fields:    Translation:Humans
    118. Masud T, Manatunga A, Cotsonis G, Mitch WE. The precision of estimating protein intake of patients with chronic renal failure. Kidney Int. 2002 Nov; 62(5):1750-6. PMID: 12371976.
      Citations: 21     Fields:    Translation:Humans
    119. Mitch WE. Malnutrition: a frequent misdiagnosis for hemodialysis patients. J Clin Invest. 2002 Aug; 110(4):437-9. PMID: 12189236.
      Citations: 38     Fields:    Translation:Humans
    120. Kaysen GA, Dubin JA, Müller HG, Mitch WE, Rosales LM, Levin NW. Relationships among inflammation nutrition and physiologic mechanisms establishing albumin levels in hemodialysis patients. Kidney Int. 2002 Jun; 61(6):2240-9. PMID: 12028466.
      Citations: 36     Fields:    Translation:Humans
    121. Pickering WP, Price SR, Bircher G, Marinovic AC, Mitch WE, Walls J. Nutrition in CAPD: serum bicarbonate and the ubiquitin-proteasome system in muscle. Kidney Int. 2002 Apr; 61(4):1286-92. PMID: 11918735.
      Citations: 43     Fields:    Translation:HumansCellsCTClinical Trials
    122. Marinovic AC, Zheng B, Mitch WE, Price SR. Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. J Biol Chem. 2002 May 10; 277(19):16673-81. PMID: 11872750.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    123. Mitch WE. Insights into the abnormalities of chronic renal disease attributed to malnutrition. J Am Soc Nephrol. 2002 Jan; 13 Suppl 1:S22-7. PMID: 11792758.
      Citations: 11     Fields:    Translation:Humans
    124. Don BR, Rosales LM, Levine NW, Mitch W, Kaysen GA. Leptin is a negative acute phase protein in chronic hemodialysis patients. Kidney Int. 2001 Mar; 59(3):1114-20. PMID: 11231368.
      Citations: 7     Fields:    Translation:Humans
    125. Agodoa L, Briggs J, Mitch W, McCleland W, Kopple J. Nutrition in ESRD patients: rationale and plan for an initiative. J Ren Nutr. 1999 Jul; 9(3):116-8. PMID: 10431027.
      Citations: 1     Fields:    Translation:Humans
    126. Mitch WE, Levy CC. Residue specificity of an endonuclease isolated from aerobacter Sp. Biochim Biophys Acta. 1972 Jan 18; 259(1):69-75. PMID: 5011975.
      Citations:    Fields:    Translation:AnimalsCells
    127. Mitch WE, Levy CC. Anomalous behavior or ribonuclease A on Sephadex G-100. Biochim Biophys Acta. 1971 Dec 28; 251(3):388-92. PMID: 11452881.
      Citations:    Fields:    Translation:Cells
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